POLRMT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)5.08377025
2apoptotic process involved in morphogenesis (GO:0060561)4.42955291
3nucleobase biosynthetic process (GO:0046112)4.33895640
4negative regulation of erythrocyte differentiation (GO:0045647)4.24765946
5regulation of mammary gland epithelial cell proliferation (GO:0033599)4.23738453
6glycine metabolic process (GO:0006544)4.20722109
7proline metabolic process (GO:0006560)4.16284952
8folic acid metabolic process (GO:0046655)4.16087735
9peptidyl-arginine omega-N-methylation (GO:0035247)4.01237982
10purine nucleobase biosynthetic process (GO:0009113)3.91604107
11Golgi transport vesicle coating (GO:0048200)3.85037165
12COPI coating of Golgi vesicle (GO:0048205)3.85037165
13lysine catabolic process (GO:0006554)3.78316711
14lysine metabolic process (GO:0006553)3.78316711
15spliceosomal tri-snRNP complex assembly (GO:0000244)3.74123874
16folic acid-containing compound biosynthetic process (GO:0009396)3.63890841
17activation of Rac GTPase activity (GO:0032863)3.53614939
183-UTR-mediated mRNA stabilization (GO:0070935)3.51782412
19planar cell polarity pathway involved in neural tube closure (GO:0090179)3.47963134
20protein localization to kinetochore (GO:0034501)3.45730935
21ribosome biogenesis (GO:0042254)3.44769252
22serine family amino acid catabolic process (GO:0009071)3.44685518
23IMP biosynthetic process (GO:0006188)3.44364138
24adherens junction assembly (GO:0034333)3.44339077
25oxaloacetate metabolic process (GO:0006107)3.43500888
26histone arginine methylation (GO:0034969)3.39552454
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.39076861
28mitotic metaphase plate congression (GO:0007080)3.38530599
29pentose-phosphate shunt (GO:0006098)3.38283526
30mannose metabolic process (GO:0006013)3.36794976
31retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.30729217
32protein complex localization (GO:0031503)3.30633784
33NADH metabolic process (GO:0006734)3.29871601
342-oxoglutarate metabolic process (GO:0006103)3.29268738
35cell-substrate adherens junction assembly (GO:0007045)3.28307812
36focal adhesion assembly (GO:0048041)3.28307812
37protein retention in ER lumen (GO:0006621)3.27993569
38rRNA transcription (GO:0009303)3.23158274
39intracellular estrogen receptor signaling pathway (GO:0030520)3.22196360
40cellular protein complex localization (GO:0034629)3.20741280
41biotin metabolic process (GO:0006768)3.20238024
42activation of MAPKKK activity (GO:0000185)3.17441345
43ribosomal small subunit biogenesis (GO:0042274)3.17372492
44regulation of NFAT protein import into nucleus (GO:0051532)3.15538332
45peptidyl-arginine N-methylation (GO:0035246)3.14237911
46peptidyl-arginine methylation (GO:0018216)3.14237911
47maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.13214300
48glucose catabolic process (GO:0006007)3.11183913
49RNA stabilization (GO:0043489)3.10077465
50mRNA stabilization (GO:0048255)3.10077465
51regulation of hexokinase activity (GO:1903299)3.09777811
52regulation of glucokinase activity (GO:0033131)3.09777811
53regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.09759589
54negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.07574814
55formation of translation preinitiation complex (GO:0001731)3.06597793
56ribosome assembly (GO:0042255)3.06410799
57protein-DNA complex disassembly (GO:0032986)3.06306810
58nucleosome disassembly (GO:0006337)3.06306810
59DNA replication checkpoint (GO:0000076)3.03840905
60T cell apoptotic process (GO:0070231)3.03746392
61negative regulation of mRNA metabolic process (GO:1903312)3.03204389
62serine family amino acid metabolic process (GO:0009069)3.02547494
63regulation of chromatin binding (GO:0035561)3.02467335
64regulation of early endosome to late endosome transport (GO:2000641)3.01525567
65regulation of translational termination (GO:0006449)3.00630781
66nuclear pore organization (GO:0006999)3.00427718
67negative regulation of mRNA processing (GO:0050686)2.98345508
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98119089
69mitotic nuclear envelope disassembly (GO:0007077)2.96744921
70regulation of mitotic spindle organization (GO:0060236)2.95114250
71positive regulation of RNA splicing (GO:0033120)2.94134817
72protein localization to chromosome, centromeric region (GO:0071459)2.93675951
73NADPH regeneration (GO:0006740)2.91086306
74DNA replication initiation (GO:0006270)2.90803908
75histone H4 deacetylation (GO:0070933)2.89277526
76folic acid transport (GO:0015884)2.88193164
77regulation of spindle organization (GO:0090224)2.88110034
78glucose 6-phosphate metabolic process (GO:0051156)2.87349822
79regulation of glucose import in response to insulin stimulus (GO:2001273)2.86670822
80negative regulation of cell size (GO:0045792)2.84550779
81serine family amino acid biosynthetic process (GO:0009070)2.82544945
82valine metabolic process (GO:0006573)2.81362973
83negative regulation of viral release from host cell (GO:1902187)2.79101570
84apoptotic process involved in development (GO:1902742)2.78247426
85tricarboxylic acid metabolic process (GO:0072350)2.77972566
86DNA unwinding involved in DNA replication (GO:0006268)2.77775436
87IMP metabolic process (GO:0046040)2.77319709
88cellular hyperosmotic response (GO:0071474)2.77134079
89folic acid-containing compound metabolic process (GO:0006760)2.76849107
90maternal placenta development (GO:0001893)2.75962805
91regulation of nuclear cell cycle DNA replication (GO:0033262)2.75716108
92nuclear pore complex assembly (GO:0051292)2.75693284
93regulation of cholesterol biosynthetic process (GO:0045540)2.74762267
94tetrahydrofolate metabolic process (GO:0046653)2.71879723
95kynurenine metabolic process (GO:0070189)2.71291397
96membrane disassembly (GO:0030397)2.70077075
97nuclear envelope disassembly (GO:0051081)2.70077075
98paraxial mesoderm development (GO:0048339)2.69223176
99convergent extension (GO:0060026)2.68757102
100ncRNA 3-end processing (GO:0043628)2.68061372
101embryonic process involved in female pregnancy (GO:0060136)2.66525470
102aspartate family amino acid catabolic process (GO:0009068)2.65842644
103mitotic chromosome condensation (GO:0007076)2.65451362
104regulation of cholesterol homeostasis (GO:2000188)2.64990117
105positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.64776264
106mitotic G1 DNA damage checkpoint (GO:0031571)2.64547709
107urea cycle (GO:0000050)2.63827663
108snRNA processing (GO:0016180)2.63777200
109UV protection (GO:0009650)2.62461505
110negative regulation of RNA splicing (GO:0033119)2.61834000
111regulation of G0 to G1 transition (GO:0070316)2.61816870
112semaphorin-plexin signaling pathway (GO:0071526)2.61638108
113positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.61075675
114activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.60127534
1154-hydroxyproline metabolic process (GO:0019471)2.58904084
116negative regulation of myotube differentiation (GO:0010832)2.58443308
117homocysteine metabolic process (GO:0050667)2.56378719
118positive regulation of nuclease activity (GO:0032075)2.55772827
119GDP-mannose metabolic process (GO:0019673)2.55685504
120cellular response to epidermal growth factor stimulus (GO:0071364)2.55519261
121metaphase plate congression (GO:0051310)2.55474922
122negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.54246047
123DNA strand elongation involved in DNA replication (GO:0006271)2.54173002
124snRNA metabolic process (GO:0016073)2.54019186
125monosaccharide biosynthetic process (GO:0046364)2.53804694
126cell-substrate junction assembly (GO:0007044)2.53641650
127epithelial cell differentiation involved in prostate gland development (GO:0060742)2.53585499
128regulation of nucleobase-containing compound transport (GO:0032239)2.53281472
129histone H3 deacetylation (GO:0070932)2.53138203
130protein maturation by protein folding (GO:0022417)2.52902032
131pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.52866349
132regulation of RNA export from nucleus (GO:0046831)2.51386921
133cytoskeletal anchoring at plasma membrane (GO:0007016)2.50531491
134modulation by virus of host process (GO:0019054)2.49996465
135cellular response to interleukin-4 (GO:0071353)2.49929348
136negative regulation of fatty acid biosynthetic process (GO:0045717)2.49029013
137regulation of translational fidelity (GO:0006450)2.48241425
138positive regulation of chromosome segregation (GO:0051984)2.46228677
139regulation of gamma-delta T cell differentiation (GO:0045586)2.45178198
140glyoxylate metabolic process (GO:0046487)2.44867928
141gluconeogenesis (GO:0006094)2.44776276
142basement membrane organization (GO:0071711)2.44723592
143regulation of translation in response to stress (GO:0043555)2.44694634
144L-serine metabolic process (GO:0006563)2.44155325
145aspartate family amino acid metabolic process (GO:0009066)2.43370516
146glutamine family amino acid biosynthetic process (GO:0009084)2.42529432
147developmental programmed cell death (GO:0010623)2.42207640
148pinocytosis (GO:0006907)2.42102467
149negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.41525825
150heterochromatin organization (GO:0070828)2.40657551
151DNA strand elongation (GO:0022616)2.39738041
152sulfur amino acid biosynthetic process (GO:0000097)2.39127619
153pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.38822055
154UMP biosynthetic process (GO:0006222)2.38822055
155pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.38822055
156UMP metabolic process (GO:0046049)2.38822055
157vitamin transmembrane transport (GO:0035461)2.36949438
158pantothenate metabolic process (GO:0015939)2.36713303
159positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.36283118
160DNA duplex unwinding (GO:0032508)2.35461057
161amino-acid betaine metabolic process (GO:0006577)2.34489539
162DNA geometric change (GO:0032392)2.34049954
163lymphocyte apoptotic process (GO:0070227)2.33843374
164receptor recycling (GO:0001881)2.33277022
165regulation of gamma-delta T cell activation (GO:0046643)2.33147541
166negative regulation of histone methylation (GO:0031061)2.32077007
167negative regulation of translational initiation (GO:0045947)2.32036947
168pteridine-containing compound metabolic process (GO:0042558)2.31648921
169mitotic G1/S transition checkpoint (GO:0044819)2.29584936
170indole-containing compound catabolic process (GO:0042436)2.29439714
171indolalkylamine catabolic process (GO:0046218)2.29439714
172tryptophan catabolic process (GO:0006569)2.29439714
173purine nucleobase metabolic process (GO:0006144)2.29288881
174regulation of posttranscriptional gene silencing (GO:0060147)2.28761038
175regulation of gene silencing by miRNA (GO:0060964)2.28761038
176regulation of gene silencing by RNA (GO:0060966)2.28761038
177negative regulation of fatty acid metabolic process (GO:0045922)2.28269828
178mitochondrial DNA metabolic process (GO:0032042)2.28239960
179histone H2A monoubiquitination (GO:0035518)2.27904953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.45864085
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.22672134
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21306798
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.91980867
5* ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.77540073
6MYC_22102868_ChIP-Seq_BL_Human2.63490397
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.53098629
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.32773363
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25039206
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.24104863
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.10812909
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.06841974
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03393025
14ZNF263_19887448_ChIP-Seq_K562_Human1.91716465
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91444395
16STAT3_1855785_ChIP-Seq_MESCs_Mouse1.91149558
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91061173
18RXR_22158963_ChIP-Seq_LIVER_Mouse1.89309014
19MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88023520
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87267883
21VDR_21846776_ChIP-Seq_THP-1_Human1.81930114
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.76411877
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76019907
24* ETS1_20019798_ChIP-Seq_JURKAT_Human1.74915009
25XRN2_22483619_ChIP-Seq_HELA_Human1.68128576
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65527502
27CIITA_25753668_ChIP-Seq_RAJI_Human1.62895631
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57033172
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53663811
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52942510
31KDM2B_26808549_Chip-Seq_K562_Human1.50284919
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50112592
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49404908
34SA1_27219007_Chip-Seq_ERYTHROID_Human1.48751149
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48667145
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.48431017
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48329999
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48104384
39CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44651963
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43657571
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41052587
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37732135
43AR_21909140_ChIP-Seq_LNCAP_Human1.35959788
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35775655
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.34317147
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32109145
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30756097
48SMC4_20622854_ChIP-Seq_HELA_Human1.30514294
49SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.29881491
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.29514254
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29026646
52KDM2B_26808549_Chip-Seq_JURKAT_Human1.27773284
53CREB1_26743006_Chip-Seq_LNCaP_Human1.27653935
54KDM5A_27292631_Chip-Seq_BREAST_Human1.25778491
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25689280
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.25330288
57* GABP_19822575_ChIP-Seq_HepG2_Human1.25136173
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25025396
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24836707
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24264933
61* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24257036
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23443121
63TCF7_22412390_ChIP-Seq_EML_Mouse1.23165118
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22825361
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22329831
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22197519
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22148347
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.21437854
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21282639
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20792246
71* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19304506
72VDR_24763502_ChIP-Seq_THP-1_Human1.17207039
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17053732
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16431886
75LXR_22292898_ChIP-Seq_THP-1_Human1.15923721
76* P68_20966046_ChIP-Seq_HELA_Human1.15540553
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.13656813
78* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13312196
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13156714
80MAF_26560356_Chip-Seq_TH1_Human1.12575084
81FOXP3_21729870_ChIP-Seq_TREG_Human1.12124888
82VDR_23849224_ChIP-Seq_CD4+_Human1.11305634
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10992397
84CLOCK_20551151_ChIP-Seq_293T_Human1.10015575
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.09562111
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09029533
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08288536
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08015813
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07565562
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06628060
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06600204
92KDM2B_26808549_Chip-Seq_DND41_Human1.06484530
93* BCOR_27268052_Chip-Seq_Bcells_Human1.06341855
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06282994
95LXR_22158963_ChIP-Seq_LIVER_Mouse1.06204378
96KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06141207
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05847915
98STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05758562
99RARA_24833708_ChIP-Seq_LIVER_Mouse1.05371820
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05200673
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.05024323
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04702356
103RACK7_27058665_Chip-Seq_MCF-7_Human1.04681761
104BCL6_27268052_Chip-Seq_Bcells_Human1.04446188
105RUNX1_22412390_ChIP-Seq_EML_Mouse1.04394839
106CTCF_26484167_Chip-Seq_Bcells_Mouse1.04167454
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03947772
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03666217
109FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03614299
110ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03206981
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02905677
112ATF3_27146783_Chip-Seq_COLON_Human1.02529475
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02356928
114SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02238755
115MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02063902
116DCP1A_22483619_ChIP-Seq_HELA_Human1.01886997
117UTX_26944678_Chip-Seq_JUKART_Human1.01342436
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01018499
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00540216
120RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99676904
121PHF8_20622854_ChIP-Seq_HELA_Human0.99450683
122ELF1_20517297_ChIP-Seq_JURKAT_Human0.99191305
123NOTCH1_21737748_ChIP-Seq_TLL_Human0.98973033
124TFEB_21752829_ChIP-Seq_HELA_Human0.98297572
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98090495
126NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95855996
127KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94731572
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94161753
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93657691
130RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93381977
131NCOR1_26117541_ChIP-Seq_K562_Human0.92733189
132MAF_26560356_Chip-Seq_TH2_Human0.92565499
133NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90545283
134BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90235759
135NANOG_21062744_ChIP-ChIP_HESCs_Human0.89867073
136OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89153076
137* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89077971
138YY1_22570637_ChIP-Seq_MALME-3M_Human0.87453193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching2.95574433
2MP0003111_abnormal_nucleus_morphology2.87011974
3MP0009840_abnormal_foam_cell2.72842221
4MP0003646_muscle_fatigue2.66963508
5MP0002139_abnormal_hepatobiliary_system2.63782167
6MP0004858_abnormal_nervous_system2.61068521
7MP0000678_abnormal_parathyroid_gland2.52015666
8MP0003191_abnormal_cellular_cholesterol2.43786921
9MP0003705_abnormal_hypodermis_morpholog2.40672702
10MP0005360_urolithiasis2.40608412
11MP0003806_abnormal_nucleotide_metabolis2.35931390
12MP0008057_abnormal_DNA_replication2.33490071
13MP0003077_abnormal_cell_cycle2.26397436
14MP0010234_abnormal_vibrissa_follicle2.22129334
15MP0005365_abnormal_bile_salt2.19822856
16MP0010094_abnormal_chromosome_stability2.16162264
17MP0004957_abnormal_blastocyst_morpholog2.13454518
18MP0002396_abnormal_hematopoietic_system2.11904318
19MP0002249_abnormal_larynx_morphology2.10764038
20MP0005451_abnormal_body_composition2.01083601
21MP0002877_abnormal_melanocyte_morpholog1.91762389
22MP0005085_abnormal_gallbladder_physiolo1.81048034
23MP0004084_abnormal_cardiac_muscle1.75879039
24MP0001730_embryonic_growth_arrest1.74671020
25MP0003453_abnormal_keratinocyte_physiol1.73770190
26MP0000003_abnormal_adipose_tissue1.73580440
27MP0002796_impaired_skin_barrier1.70275403
28MP0000537_abnormal_urethra_morphology1.67147913
29MP0005083_abnormal_biliary_tract1.66784575
30MP0004233_abnormal_muscle_weight1.65501623
31MP0010352_gastrointestinal_tract_polyps1.64985676
32MP0010030_abnormal_orbit_morphology1.63853046
33MP0005501_abnormal_skin_physiology1.62299083
34MP0005375_adipose_tissue_phenotype1.60615925
35MP0002269_muscular_atrophy1.57264735
36MP0005623_abnormal_meninges_morphology1.57085370
37MP0010307_abnormal_tumor_latency1.55977641
38MP0008058_abnormal_DNA_repair1.55729248
39MP0003172_abnormal_lysosome_physiology1.54705872
40MP0003221_abnormal_cardiomyocyte_apopto1.54095359
41MP0005409_darkened_coat_color1.48390537
42MP0000858_altered_metastatic_potential1.44507106
43MP0005330_cardiomyopathy1.43291545
44MP0000750_abnormal_muscle_regeneration1.43206866
45MP0000566_synostosis1.42856223
46MP0005319_abnormal_enzyme/_coenzyme1.41884080
47MP0001672_abnormal_embryogenesis/_devel1.41872712
48MP0005380_embryogenesis_phenotype1.41872712
49MP0008007_abnormal_cellular_replicative1.39528502
50MP0000609_abnormal_liver_physiology1.38266447
51MP0002254_reproductive_system_inflammat1.38094838
52MP0006036_abnormal_mitochondrial_physio1.36447772
53MP0005076_abnormal_cell_differentiation1.36406715
54MP0003984_embryonic_growth_retardation1.35185983
55MP0005332_abnormal_amino_acid1.34129460
56MP0003566_abnormal_cell_adhesion1.33567797
57MP0000350_abnormal_cell_proliferation1.31852996
58MP0002088_abnormal_embryonic_growth/wei1.31557005
59MP0009333_abnormal_splenocyte_physiolog1.30913113
60MP0000751_myopathy1.30853634
61MP0004808_abnormal_hematopoietic_stem1.24079695
62MP0001545_abnormal_hematopoietic_system1.22676446
63MP0005397_hematopoietic_system_phenotyp1.22676446
64MP0004947_skin_inflammation1.20213992
65MP0001661_extended_life_span1.18563141
66MP0000685_abnormal_immune_system1.18318611
67MP0010329_abnormal_lipoprotein_level1.17719345
68MP0003763_abnormal_thymus_physiology1.14858620
69MP0003123_paternal_imprinting1.14118824
70MP0001697_abnormal_embryo_size1.13149178
71MP0004087_abnormal_muscle_fiber1.13111734
72MP0009278_abnormal_bone_marrow1.13065365
73MP0000747_muscle_weakness1.12003160
74MP0002080_prenatal_lethality1.11695634
75MP0005621_abnormal_cell_physiology1.10818103
76MP0000759_abnormal_skeletal_muscle1.10391688
77MP0003567_abnormal_fetal_cardiomyocyte1.08141981
78MP0000490_abnormal_crypts_of1.07247677
79MP0006035_abnormal_mitochondrial_morpho1.06696112
80MP0003436_decreased_susceptibility_to1.06462648
81MP0010630_abnormal_cardiac_muscle1.06339805
82MP0000313_abnormal_cell_death1.03670407
83MP0000358_abnormal_cell_content/1.03383924
84MP0005670_abnormal_white_adipose1.03270296
85MP0000749_muscle_degeneration1.02982487
86MP0002086_abnormal_extraembryonic_tissu1.02802658
87MP0004036_abnormal_muscle_relaxation1.02446692
88MP0008961_abnormal_basal_metabolism1.01174121
89MP0000598_abnormal_liver_morphology1.00693827
90MP0008775_abnormal_heart_ventricle1.00456410
91MP0008932_abnormal_embryonic_tissue1.00314420
92MP0004197_abnormal_fetal_growth/weight/0.98211555
93MP0005266_abnormal_metabolism0.97558273
94MP0002019_abnormal_tumor_incidence0.96081250
95MP0002106_abnormal_muscle_physiology0.94195743
96MP0000689_abnormal_spleen_morphology0.93659727
97MP0002398_abnormal_bone_marrow0.93412092
98MP0004264_abnormal_extraembryonic_tissu0.93148871
99MP0004185_abnormal_adipocyte_glucose0.92760293
100MP0000733_abnormal_muscle_development0.92407713
101MP0002722_abnormal_immune_system0.91594850
102MP0005023_abnormal_wound_healing0.91114220
103MP0001348_abnormal_lacrimal_gland0.90185056
104MP0009672_abnormal_birth_weight0.90181954
105MP0003115_abnormal_respiratory_system0.90070374
106MP0002060_abnormal_skin_morphology0.89671626
107MP0005257_abnormal_intraocular_pressure0.89320501
108MP0003091_abnormal_cell_migration0.89018025
109MP0000013_abnormal_adipose_tissue0.88926279
110MP0001849_ear_inflammation0.88467516
111MP0001915_intracranial_hemorrhage0.88180602
112MP0000569_abnormal_digit_pigmentation0.87629057
113MP0001800_abnormal_humoral_immune0.87053069
114MP0001835_abnormal_antigen_presentation0.86212738
115MP0005666_abnormal_adipose_tissue0.85873163
116MP0003786_premature_aging0.85475270
117MP0009931_abnormal_skin_appearance0.85257967
118MP0004019_abnormal_vitamin_homeostasis0.85137004
119MP0003303_peritoneal_inflammation0.84805761
120MP0009379_abnormal_foot_pigmentation0.84745308
121MP0008260_abnormal_autophagy0.84710350
122MP0004272_abnormal_basement_membrane0.84531358
123MP0004510_myositis0.83545460
124MP0003718_maternal_effect0.83369244
125MP0002970_abnormal_white_adipose0.81987395
126MP0005384_cellular_phenotype0.81606766
127MP0009643_abnormal_urine_homeostasis0.80818427
128MP0002089_abnormal_postnatal_growth/wei0.80751725
129MP0003329_amyloid_beta_deposits0.80709540
130MP0000477_abnormal_intestine_morphology0.80575670
131MP0001544_abnormal_cardiovascular_syste0.80540850
132MP0005385_cardiovascular_system_phenoty0.80540850
133MP0003252_abnormal_bile_duct0.80273792
134MP0000371_diluted_coat_color0.80247345
135MP0005058_abnormal_lysosome_morphology0.80074569
136MP0000703_abnormal_thymus_morphology0.78476075
137MP0003300_gastrointestinal_ulcer0.77979860
138MP0002429_abnormal_blood_cell0.77694960
139MP0002085_abnormal_embryonic_tissue0.77630044
140MP0000681_abnormal_thyroid_gland0.75318438
141MP0003385_abnormal_body_wall0.74629851
142MP0001873_stomach_inflammation0.73294189
143MP0006138_congestive_heart_failure0.72764737
144MP0001216_abnormal_epidermal_layer0.70734380
145MP0001346_abnormal_lacrimal_gland0.70409633
146MP0009384_cardiac_valve_regurgitation0.69796538
147MP0000762_abnormal_tongue_morphology0.69113493
148MP0000467_abnormal_esophagus_morphology0.67983675

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)4.31378709
2Hyperglycinemia (HP:0002154)3.84470532
3Abnormality of serine family amino acid metabolism (HP:0010894)3.61239395
4Abnormality of glycine metabolism (HP:0010895)3.61239395
5Ulnar bowing (HP:0003031)3.17683050
6Distal lower limb amyotrophy (HP:0008944)3.02901991
7Multiple enchondromatosis (HP:0005701)2.99122734
8Ependymoma (HP:0002888)2.98043303
9Centrally nucleated skeletal muscle fibers (HP:0003687)2.97124804
10Abnormality of pyrimidine metabolism (HP:0004353)2.87801056
11Myopathic facies (HP:0002058)2.86514785
12Muscle fiber splitting (HP:0003555)2.86158645
13Obstructive sleep apnea (HP:0002870)2.86140891
14Stridor (HP:0010307)2.84352537
15Achilles tendon contracture (HP:0001771)2.77978184
16Abnormal gallbladder physiology (HP:0012438)2.75895654
17Cholecystitis (HP:0001082)2.75895654
18Difficulty climbing stairs (HP:0003551)2.70615002
19Gout (HP:0001997)2.69586011
20Broad face (HP:0000283)2.69450428
21Long palpebral fissure (HP:0000637)2.68411246
22Hyperammonemia (HP:0001987)2.67640011
23Ragged-red muscle fibers (HP:0003200)2.67439309
24Increased connective tissue (HP:0009025)2.64966395
25Broad distal phalanx of finger (HP:0009836)2.63858863
26Progressive muscle weakness (HP:0003323)2.61428304
27Abnormality of the Achilles tendon (HP:0005109)2.50384083
28Disproportionate tall stature (HP:0001519)2.48484061
29Abnormality of monocarboxylic acid metabolism (HP:0010996)2.46554927
30Insomnia (HP:0100785)2.42332534
31Abnormality of fatty-acid metabolism (HP:0004359)2.41468265
32Atrioventricular block (HP:0001678)2.37399185
33Autoimmune thrombocytopenia (HP:0001973)2.35651602
34Hemorrhage of the eye (HP:0011885)2.29694428
35Xanthomatosis (HP:0000991)2.29088851
36Distal lower limb muscle weakness (HP:0009053)2.28534096
37Trismus (HP:0000211)2.26072160
38Abnormality of serum amino acid levels (HP:0003112)2.25648624
39Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25079633
40Dicarboxylic aciduria (HP:0003215)2.25079633
41Turricephaly (HP:0000262)2.24194678
42Progressive external ophthalmoplegia (HP:0000590)2.23138113
43Premature skin wrinkling (HP:0100678)2.21690695
44Truncus arteriosus (HP:0001660)2.20714409
45Bundle branch block (HP:0011710)2.20507318
46Ketosis (HP:0001946)2.19918760
47Exercise-induced myalgia (HP:0003738)2.17248168
48Carpal bone hypoplasia (HP:0001498)2.17091927
49Ventricular tachycardia (HP:0004756)2.16254732
50Microvesicular hepatic steatosis (HP:0001414)2.16240595
51Impulsivity (HP:0100710)2.13378578
52Shallow orbits (HP:0000586)2.12590760
53Lymphangioma (HP:0100764)2.12330620
54Reticulocytosis (HP:0001923)2.11761703
55Selective tooth agenesis (HP:0001592)2.11010280
56Increased variability in muscle fiber diameter (HP:0003557)2.10965115
57Pointed chin (HP:0000307)2.10523698
58Lower limb amyotrophy (HP:0007210)2.09510559
59Cerebral aneurysm (HP:0004944)2.09327646
60Biconcave vertebral bodies (HP:0004586)2.08928190
61Hypochromic anemia (HP:0001931)2.08780430
62Entropion (HP:0000621)2.07950912
63Breech presentation (HP:0001623)2.07453495
64Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.04940503
65Rectal prolapse (HP:0002035)2.04853464
66Dysmetric saccades (HP:0000641)2.04416875
67Abnormality of the thoracic spine (HP:0100711)2.04089919
68Spastic diplegia (HP:0001264)2.03184803
69Rhabdomyolysis (HP:0003201)2.02937405
70Hyperacusis (HP:0010780)2.02675459
71Myoglobinuria (HP:0002913)2.02229364
72Fatigue (HP:0012378)2.01578348
73Broad metatarsal (HP:0001783)2.01279634
74Deep venous thrombosis (HP:0002625)2.01225767
75Abnormality of skeletal muscle fiber size (HP:0012084)2.00521752
76Metaphyseal cupping (HP:0003021)2.00183993
77Abnormality of nucleobase metabolism (HP:0010932)2.00082683
78Joint hemorrhage (HP:0005261)1.98277470
79Urethral obstruction (HP:0000796)1.97626787
80Abnormality of the lower motor neuron (HP:0002366)1.97181750
81Abnormality of glutamine family amino acid metabolism (HP:0010902)1.96603445
82Vertebral compression fractures (HP:0002953)1.96345294
83Premature rupture of membranes (HP:0001788)1.93406930
84Degeneration of anterior horn cells (HP:0002398)1.92974632
85Abnormality of the anterior horn cell (HP:0006802)1.92974632
86Upper limb amyotrophy (HP:0009129)1.92751391
87Distal upper limb amyotrophy (HP:0007149)1.92751391
88Abnormality of aromatic amino acid family metabolism (HP:0004338)1.92633086
89Rough bone trabeculation (HP:0100670)1.90125393
90Lipoatrophy (HP:0100578)1.89950449
91Hand muscle atrophy (HP:0009130)1.89916978
92Ankyloglossia (HP:0010296)1.89745236
93Easy fatigability (HP:0003388)1.88982192
94Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87361316
95Flat acetabular roof (HP:0003180)1.86600683
96Nausea (HP:0002018)1.86475258
97Abnormality of the calcaneus (HP:0008364)1.85674169
98Abnormality of the fingertips (HP:0001211)1.85611327
99Ketoacidosis (HP:0001993)1.85308361
100Hypobetalipoproteinemia (HP:0003563)1.85214412
101Thin bony cortex (HP:0002753)1.84907024
102Abnormality of sulfur amino acid metabolism (HP:0004339)1.84759952
103Oral leukoplakia (HP:0002745)1.84641789
104Abnormal cartilage morphology (HP:0002763)1.84446931
105Hypoglycemic coma (HP:0001325)1.84291750
106Seborrheic dermatitis (HP:0001051)1.83502376
107Thin ribs (HP:0000883)1.83134749
108Deep palmar crease (HP:0006191)1.83080094
109Albinism (HP:0001022)1.82691661
110Abnormality of oral frenula (HP:0000190)1.82539895
111Intrahepatic cholestasis (HP:0001406)1.82533957
112Ankle contracture (HP:0006466)1.82049336
113Increased serum ferritin (HP:0003281)1.81128660
114Mitral regurgitation (HP:0001653)1.79763664
115Areflexia of lower limbs (HP:0002522)1.79300212
116Neonatal death (HP:0003811)1.79043047
117Bronchomalacia (HP:0002780)1.78490434
118Cellulitis (HP:0100658)1.78432928
119Generalized amyotrophy (HP:0003700)1.77952939
120Abnormality of iron homeostasis (HP:0011031)1.77839285
121Premature ovarian failure (HP:0008209)1.77661019
122Colitis (HP:0002583)1.76496816
123Cerebral hypomyelination (HP:0006808)1.75831930
124Mesomelia (HP:0003027)1.75463625
125Mildly elevated creatine phosphokinase (HP:0008180)1.74899057
126Polygenic inheritance (HP:0010982)1.74721314
127Calcaneovalgus deformity (HP:0001848)1.74280288
128Mesangial abnormality (HP:0001966)1.74123595
129Bowel incontinence (HP:0002607)1.73955761
130Abnormality of reticulocytes (HP:0004312)1.73816758
131Spinal rigidity (HP:0003306)1.72501684
132Chromsome breakage (HP:0040012)1.72463336
133Gastrointestinal dysmotility (HP:0002579)1.72376068
134Protrusio acetabuli (HP:0003179)1.70825803
135Pseudobulbar signs (HP:0002200)1.70587496
136Diaphragmatic weakness (HP:0009113)1.70562439
137Muscle stiffness (HP:0003552)1.69728378
138Astrocytoma (HP:0009592)1.69539975
139Abnormality of the astrocytes (HP:0100707)1.69539975
140Bulbar palsy (HP:0001283)1.69492846
141Neurodegeneration (HP:0002180)1.69278818
142Patellar dislocation (HP:0002999)1.69069144
143Frequent falls (HP:0002359)1.69053569
144Overriding aorta (HP:0002623)1.67878448
145Broad palm (HP:0001169)1.66995824
146Ureteral duplication (HP:0000073)1.66876997
147Fragile skin (HP:0001030)1.66233493
148Abnormality of the distal phalanges of the toes (HP:0010182)1.66132623
149Abnormal neuron morphology (HP:0012757)1.65827372
150Abnormality of the motor neurons (HP:0002450)1.65827372
151Abnormality of the left ventricular outflow tract (HP:0011103)1.65487554
152Subaortic stenosis (HP:0001682)1.65487554
153Abnormal large intestine physiology (HP:0012700)1.65429984
154Hypertensive crisis (HP:0100735)1.65393583
155Birth length less than 3rd percentile (HP:0003561)1.63776192
156Thoracic kyphosis (HP:0002942)1.63752786
157Annular pancreas (HP:0001734)1.63515475
158EMG: neuropathic changes (HP:0003445)1.63142573
159Advanced eruption of teeth (HP:0006288)1.62752600
160Reduced subcutaneous adipose tissue (HP:0003758)1.62575606
161J-shaped sella turcica (HP:0002680)1.62549417
162Arnold-Chiari malformation (HP:0002308)1.62405290
163Abnormality of transition element cation homeostasis (HP:0011030)1.62022168
164Heart block (HP:0012722)1.61903085
165Abnormality of the salivary glands (HP:0010286)1.61581716
166Elfin facies (HP:0004428)1.59732331
167Abnormality of the distal phalanx of the thumb (HP:0009617)1.59678424
168Pelvic girdle muscle weakness (HP:0003749)1.59218972
169Deformed tarsal bones (HP:0008119)1.58830944
170Back pain (HP:0003418)1.58584773
171Cholelithiasis (HP:0001081)1.58020823
172Megaloblastic anemia (HP:0001889)1.57906230
173Personality changes (HP:0000751)1.57662945
174Increased purine levels (HP:0004368)1.57484409
175Hyperuricemia (HP:0002149)1.57484409
176Upper motor neuron abnormality (HP:0002127)1.56810186
177Hypolipoproteinemia (HP:0010981)1.56703083
178Abnormality of the tricuspid valve (HP:0001702)1.56565697
179Deviation of the thumb (HP:0009603)1.56464164
180Proximal placement of thumb (HP:0009623)1.54975517
181High anterior hairline (HP:0009890)1.54217959
182Hypertriglyceridemia (HP:0002155)1.53953259
183Elbow flexion contracture (HP:0002987)1.51601820

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.10738519
2TRIB33.55945565
3PRPF4B3.16364417
4PKN23.11517622
5EEF2K2.90577406
6BUB12.68574712
7NEK22.46250694
8CDK122.45897508
9MAP3K102.32994996
10NME22.31991417
11IRAK32.25386571
12TTN2.23859581
13WEE12.13702887
14MAP4K12.08558493
15BCKDK2.01894345
16BMX1.96808127
17CDC71.81472823
18ERN11.77739415
19NEK11.66796827
20MST1R1.64452277
21PASK1.56355996
22CAMK1D1.54150162
23CDK41.53190364
24PIM21.52568899
25FGFR41.49452531
26TSSK61.47692208
27ALK1.42558130
28MAP2K31.38159115
29FLT31.32383292
30MAP3K131.29691004
31PLK11.27734773
32ICK1.26171306
33TTK1.25923974
34EIF2AK11.24639730
35TAOK11.24018342
36PRKD31.22692088
37PDK31.21347870
38PDK41.21347870
39LATS21.11544281
40ZAP701.09162116
41ARAF1.04671881
42CAMK1G1.04540856
43PIM11.02590376
44CDK71.02435685
45MAP3K81.00154375
46MTOR1.00007753
47PDGFRA0.98476266
48ATR0.97185708
49MARK20.97017675
50LMTK20.95099469
51LRRK20.95078338
52AURKB0.94254211
53SCYL20.93701184
54PRKD20.92974562
55KSR20.91351409
56CAMKK10.91042709
57BRSK10.90154052
58MAPK110.90006707
59AKT20.89912133
60SIK10.89723396
61PTK60.89647426
62RPS6KB20.89540466
63MAP3K110.89523198
64SIK20.87998444
65MAP3K10.87110116
66MAP2K20.85629786
67BRSK20.84724712
68JAK30.83240538
69EPHA20.83138733
70MAPKAPK30.83055615
71PAK40.82043699
72EPHB10.82008127
73RIPK10.81617133
74TYK20.81260799
75BRAF0.81229718
76ZAK0.80149160
77NTRK10.79916977
78RPS6KA40.79840549
79CHEK10.78505097
80STK100.78263221
81BTK0.78186746
82STK30.76970289
83AURKA0.76413112
84TESK10.73280095
85PTK20.73188062
86PDK20.72628486
87PINK10.70535661
88RPS6KA20.70489556
89CDC42BPA0.70454091
90PLK40.70239431
91STK38L0.69163303
92IKBKB0.68288603
93CSF1R0.67746299
94MAP3K60.65645887
95MAP3K70.65410979
96PDPK10.65304514
97TBK10.64436996
98TGFBR10.64362114
99RAF10.64116235
100TYRO30.63296098
101STK40.62584798
102KDR0.61591991
103IRAK20.60615538
104JAK10.60494528
105DYRK30.60046392
106MET0.58763546
107NME10.58685650
108TESK20.57878971
109CDK20.57333473
110MAP3K30.56541630
111GRK60.55748767
112SRPK10.55580481
113MAP3K140.55525260
114LATS10.55096493
115RPS6KA60.54820857
116JAK20.54204472
117MAP3K50.54113143
118TAOK20.52892260
119CHUK0.52099067
120PRKAA10.51655699
121HIPK20.50680391
122MAPK120.50355147
123RPS6KC10.49289553
124RPS6KL10.49289553
125TNK20.49099533
126KIT0.48462683
127SIK30.47934254
128RPS6KA10.47573474
129MAP3K90.46842869
130CLK10.46819632
131PRKG20.45354122
132CAMK40.43041128
133CHEK20.39972866
134VRK20.39783818
135CDK90.39487827
136OBSCN0.38096897
137CDK80.37628095
138ACVR1B0.37409774
139CDK60.36087578
140IRAK40.35007218
141DYRK1B0.32888150
142PAK10.31057952
143RET0.30751907

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.31310830
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.30952384
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.42165340
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.41319725
5Other glycan degradation_Homo sapiens_hsa005112.32952494
6DNA replication_Homo sapiens_hsa030302.30391842
7One carbon pool by folate_Homo sapiens_hsa006702.29910269
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.20285088
9Vitamin B6 metabolism_Homo sapiens_hsa007502.20225636
10Biosynthesis of amino acids_Homo sapiens_hsa012302.13011882
11Base excision repair_Homo sapiens_hsa034102.03049135
12Carbon metabolism_Homo sapiens_hsa012001.92733584
13Drug metabolism - other enzymes_Homo sapiens_hsa009831.91468486
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.84217925
15RNA transport_Homo sapiens_hsa030131.80945255
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80300420
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77245494
18Folate biosynthesis_Homo sapiens_hsa007901.73108756
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.68795341
20Arginine biosynthesis_Homo sapiens_hsa002201.67699222
21RNA polymerase_Homo sapiens_hsa030201.65264540
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.63553748
23Bladder cancer_Homo sapiens_hsa052191.62084798
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.60164515
25Selenocompound metabolism_Homo sapiens_hsa004501.58978719
26Fatty acid degradation_Homo sapiens_hsa000711.58103766
27Non-small cell lung cancer_Homo sapiens_hsa052231.53085169
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52969891
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49557583
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.47375620
31Propanoate metabolism_Homo sapiens_hsa006401.47017063
32Pentose phosphate pathway_Homo sapiens_hsa000301.45804566
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44303401
34Pyrimidine metabolism_Homo sapiens_hsa002401.43134286
35VEGF signaling pathway_Homo sapiens_hsa043701.42936402
36beta-Alanine metabolism_Homo sapiens_hsa004101.38898015
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38177704
38Spliceosome_Homo sapiens_hsa030401.36781142
39Fructose and mannose metabolism_Homo sapiens_hsa000511.34549312
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.33183467
41Sulfur relay system_Homo sapiens_hsa041221.29613418
42Mismatch repair_Homo sapiens_hsa034301.27600184
43Tryptophan metabolism_Homo sapiens_hsa003801.26985599
44Vitamin digestion and absorption_Homo sapiens_hsa049771.25871129
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25573887
46Pancreatic cancer_Homo sapiens_hsa052121.25378665
47Prion diseases_Homo sapiens_hsa050201.20430221
48Cell cycle_Homo sapiens_hsa041101.12973633
49B cell receptor signaling pathway_Homo sapiens_hsa046621.09417798
50Lysine degradation_Homo sapiens_hsa003101.08588717
51Starch and sucrose metabolism_Homo sapiens_hsa005001.08027678
52Endometrial cancer_Homo sapiens_hsa052131.07540191
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05037143
54Arginine and proline metabolism_Homo sapiens_hsa003301.04092708
55Pyruvate metabolism_Homo sapiens_hsa006200.98397447
56p53 signaling pathway_Homo sapiens_hsa041150.97329803
57PPAR signaling pathway_Homo sapiens_hsa033200.97093469
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.96939062
59Galactose metabolism_Homo sapiens_hsa000520.94802695
60Glioma_Homo sapiens_hsa052140.93725810
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93571771
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91811583
63Homologous recombination_Homo sapiens_hsa034400.91048583
64Fatty acid metabolism_Homo sapiens_hsa012120.90341378
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88988917
66Butanoate metabolism_Homo sapiens_hsa006500.87787654
67ErbB signaling pathway_Homo sapiens_hsa040120.86896770
68Colorectal cancer_Homo sapiens_hsa052100.86533532
69Nitrogen metabolism_Homo sapiens_hsa009100.82553079
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81960562
71Non-homologous end-joining_Homo sapiens_hsa034500.81755304
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79011891
73Peroxisome_Homo sapiens_hsa041460.78482550
74MicroRNAs in cancer_Homo sapiens_hsa052060.77881586
75Complement and coagulation cascades_Homo sapiens_hsa046100.76928250
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76608423
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.76474935
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75569332
79Proteasome_Homo sapiens_hsa030500.75039829
80Insulin resistance_Homo sapiens_hsa049310.73276470
81Nucleotide excision repair_Homo sapiens_hsa034200.72466354
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.72365495
83Inositol phosphate metabolism_Homo sapiens_hsa005620.69338152
84Epstein-Barr virus infection_Homo sapiens_hsa051690.69150486
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.67381130
86Renal cell carcinoma_Homo sapiens_hsa052110.66452802
87Shigellosis_Homo sapiens_hsa051310.66335104
88Phenylalanine metabolism_Homo sapiens_hsa003600.65925229
89Acute myeloid leukemia_Homo sapiens_hsa052210.65126354
90Hepatitis B_Homo sapiens_hsa051610.64878428
91Prostate cancer_Homo sapiens_hsa052150.64427899
92Legionellosis_Homo sapiens_hsa051340.64156737
93Apoptosis_Homo sapiens_hsa042100.61346064
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60997516
95Herpes simplex infection_Homo sapiens_hsa051680.60977955
96mRNA surveillance pathway_Homo sapiens_hsa030150.60772919
97Choline metabolism in cancer_Homo sapiens_hsa052310.60131256
98N-Glycan biosynthesis_Homo sapiens_hsa005100.59912769
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59273737
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58337534
101Primary immunodeficiency_Homo sapiens_hsa053400.57940896
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57859203
103mTOR signaling pathway_Homo sapiens_hsa041500.57678917
104GnRH signaling pathway_Homo sapiens_hsa049120.57486881
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57141245
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.56467211
107Focal adhesion_Homo sapiens_hsa045100.55978263
108Small cell lung cancer_Homo sapiens_hsa052220.55898252
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55856656
110Glucagon signaling pathway_Homo sapiens_hsa049220.54402786
111Hepatitis C_Homo sapiens_hsa051600.52712643
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52672326
113Antigen processing and presentation_Homo sapiens_hsa046120.52233071
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.51773920
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51377206
116Adherens junction_Homo sapiens_hsa045200.50936286
117Purine metabolism_Homo sapiens_hsa002300.49389369
118Proteoglycans in cancer_Homo sapiens_hsa052050.49131807
119Glutathione metabolism_Homo sapiens_hsa004800.46583550
120HIF-1 signaling pathway_Homo sapiens_hsa040660.45020316
121Estrogen signaling pathway_Homo sapiens_hsa049150.44608343
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.44284113
123RNA degradation_Homo sapiens_hsa030180.44143324
124Endocytosis_Homo sapiens_hsa041440.43301216
125Notch signaling pathway_Homo sapiens_hsa043300.43113574
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.42888560
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41942552
128Staphylococcus aureus infection_Homo sapiens_hsa051500.38826828
129Viral carcinogenesis_Homo sapiens_hsa052030.38440559
130Histidine metabolism_Homo sapiens_hsa003400.38302771
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38182877
132Insulin signaling pathway_Homo sapiens_hsa049100.37067582
133Ribosome_Homo sapiens_hsa030100.36999003
134AMPK signaling pathway_Homo sapiens_hsa041520.36653595
135HTLV-I infection_Homo sapiens_hsa051660.35896179
136Bile secretion_Homo sapiens_hsa049760.35100781
137Viral myocarditis_Homo sapiens_hsa054160.33912397
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32596302
139Chronic myeloid leukemia_Homo sapiens_hsa052200.32234934
140Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31915964
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31485973
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30967008
143Thyroid cancer_Homo sapiens_hsa052160.30526314
144Fat digestion and absorption_Homo sapiens_hsa049750.28985241
145Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28305031

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