ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	transcription from mitochondrial promoter (GO:0006390)	5.62751475
2	establishment of integrated proviral latency (GO:0075713)	4.82427781
3	mitochondrial RNA metabolic process (GO:0000959)	4.81107532
4	establishment of viral latency (GO:0019043)	4.78079310
5	peptidyl-arginine omega-N-methylation (GO:0035247)	4.41849230
6	regulation of mitochondrial translation (GO:0070129)	4.08770043
7	metallo-sulfur cluster assembly (GO:0031163)	3.97970844
8	iron-sulfur cluster assembly (GO:0016226)	3.97970844
9	ribosome biogenesis (GO:0042254)	3.96815334
10	proline biosynthetic process (GO:0006561)	3.89171039
11	tRNA methylation (GO:0030488)	3.85683030
12	ribosomal small subunit assembly (GO:0000028)	3.58886584
13	peptidyl-arginine N-methylation (GO:0035246)	3.58655637
14	peptidyl-arginine methylation (GO:0018216)	3.58655637
15	histone arginine methylation (GO:0034969)	3.58294178
16	pentose metabolic process (GO:0019321)	3.46964098
17	tRNA aminoacylation for protein translation (GO:0006418)	3.45775424
18	DNA deamination (GO:0045006)	3.45495056
19	ribonucleoprotein complex biogenesis (GO:0022613)	3.39167869
20	amino acid activation (GO:0043038)	3.38524371
21	tRNA aminoacylation (GO:0043039)	3.38524371
22	formation of translation preinitiation complex (GO:0001731)	3.38367546
23	inner mitochondrial membrane organization (GO:0007007)	3.35381325
24	regulation of translational fidelity (GO:0006450)	3.33290677
25	DNA ligation (GO:0006266)	3.29200457
26	COPI coating of Golgi vesicle (GO:0048205)	3.25090125
27	Golgi transport vesicle coating (GO:0048200)	3.25090125
28	proteasome assembly (GO:0043248)	3.21754829
29	ribosomal large subunit biogenesis (GO:0042273)	3.20925390
30	rRNA modification (GO:0000154)	3.20610629
31	pseudouridine synthesis (GO:0001522)	3.18968267
32	homocysteine metabolic process (GO:0050667)	3.18002472
33	DNA strand elongation involved in DNA replication (GO:0006271)	3.17479867
34	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	3.16393448
35	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.12368991
36	DNA strand elongation (GO:0022616)	3.10168055
37	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.09977403
38	mitotic chromosome condensation (GO:0007076)	3.09781910
39	telomere maintenance via semi-conservative replication (GO:0032201)	3.09770911
40	tRNA modification (GO:0006400)	3.07923773
41	GDP-mannose metabolic process (GO:0019673)	3.05101509
42	spliceosomal snRNP assembly (GO:0000387)	3.03653984
43	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.03302340
44	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.03302340
45	purine ribonucleotide transport (GO:0015868)	2.97893263
46	serine family amino acid biosynthetic process (GO:0009070)	2.97346635
47	proline metabolic process (GO:0006560)	2.95995480
48	cellular component biogenesis (GO:0044085)	2.92926671
49	cysteine metabolic process (GO:0006534)	2.91886491
50	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.90693521
51	termination of RNA polymerase III transcription (GO:0006386)	2.90693521
52	maturation of 5.8S rRNA (GO:0000460)	2.89096372
53	base-excision repair, AP site formation (GO:0006285)	2.87547612
54	IMP biosynthetic process (GO:0006188)	2.86656857
55	synapsis (GO:0007129)	2.86556358
56	protein targeting to mitochondrion (GO:0006626)	2.86455509
57	nitrogen cycle metabolic process (GO:0071941)	2.84357723
58	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.83813359
59	ncRNA 3-end processing (GO:0043628)	2.83566279
60	base-excision repair (GO:0006284)	2.83001004
61	nucleotide salvage (GO:0043173)	2.81384048
62	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.81065462
63	protein maturation by protein folding (GO:0022417)	2.80794305
64	urea cycle (GO:0000050)	2.80320632
65	rRNA processing (GO:0006364)	2.79893186
66	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.78621493
67	tRNA metabolic process (GO:0006399)	2.78265034
68	DNA replication initiation (GO:0006270)	2.76361642
69	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.74701790
70	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.72604106
71	L-alpha-amino acid transmembrane transport (GO:1902475)	2.70913711
72	rRNA methylation (GO:0031167)	2.70883515
73	establishment of protein localization to mitochondrion (GO:0072655)	2.68240282
74	rRNA transcription (GO:0009303)	2.67876287
75	cholesterol biosynthetic process (GO:0006695)	2.66887517
76	DNA replication checkpoint (GO:0000076)	2.66822665
77	peptidyl-histidine modification (GO:0018202)	2.66612056
78	positive regulation of receptor biosynthetic process (GO:0010870)	2.65968560
79	rRNA metabolic process (GO:0016072)	2.65555448
80	ribosome assembly (GO:0042255)	2.65446319
81	mitochondrial DNA metabolic process (GO:0032042)	2.64211590
82	protein localization to mitochondrion (GO:0070585)	2.63500249
83	adenine nucleotide transport (GO:0051503)	2.63436109
84	tRNA processing (GO:0008033)	2.63415710
85	oxaloacetate metabolic process (GO:0006107)	2.62429148
86	L-serine metabolic process (GO:0006563)	2.61704402
87	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.60470257
88	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.60217942
89	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.60208482
90	negative regulation of mRNA processing (GO:0050686)	2.57759022
91	mannosylation (GO:0097502)	2.57633078
92	biotin metabolic process (GO:0006768)	2.57043571
93	negative regulation of ligase activity (GO:0051352)	2.56497258
94	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.56497258
95	urea metabolic process (GO:0019627)	2.56156345
96	RNA methylation (GO:0001510)	2.54339947
97	pentose-phosphate shunt (GO:0006098)	2.53683174
98	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.53475732
99	piRNA metabolic process (GO:0034587)	2.53150299
100	ncRNA metabolic process (GO:0034660)	2.52230192

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.28155451
2	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.60423622
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.55089789
4	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.40188231
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.35582901
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.18301717
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.16319869
8	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.01572400
9	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.84730806
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.82271532
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.54924416
12	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.48515488
13	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.47792789
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.43254983
15	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.37596254
16	XRN2_22483619_ChIP-Seq_HELA_Human	2.36748875
17	ZNF263_19887448_ChIP-Seq_K562_Human	2.33337832
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.32623605
19	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.28632213
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.23525203
21	GABP_19822575_ChIP-Seq_HepG2_Human	2.19912744
22	DCP1A_22483619_ChIP-Seq_HELA_Human	2.18500517
23	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.15378758
24	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.08956542
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.08931839
26	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	2.04352482
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.03047020
28	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.99484974
29	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.90005425
30	FOXP3_21729870_ChIP-Seq_TREG_Human	1.84239663
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.84234225
32	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.83319647
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.78391792
34	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.77928275
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.76616516
36	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.76563825
37	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.75783452
38	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.71022507
39	MYC_22102868_ChIP-Seq_BL_Human	1.65138528
40	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.63522965
41	KDM5A_27292631_Chip-Seq_BREAST_Human	1.61381585
42	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.60859217
43	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.59813785
44	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.57842999
45	CIITA_25753668_ChIP-Seq_RAJI_Human	1.57597728
46	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.53273452
47	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.53198411
48	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.52253441
49	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.50723133
50	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.45859533
51	TFEB_21752829_ChIP-Seq_HELA_Human	1.45775390
52	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.45031537
53	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.44401688
54	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.43974631
55	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.42497825
56	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.41294867
57	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.39176993
58	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.36557692
59	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.35281474
60	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.34774001
61	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.34101782
62	VDR_21846776_ChIP-Seq_THP-1_Human	1.32999775
63	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.29506046
64	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.29210083
65	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.27032486
66	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.25372795
67	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.23883808
68	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.23522494
69	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.22614274
70	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.20269492
71	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.17092445
72	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.15919186
73	P68_20966046_ChIP-Seq_HELA_Human	1.14902923
74	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.14002941
75	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.13474122
76	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.12131692
77	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.11586432
78	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.09764264
79	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.07675487
80	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.06304585
81	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.05800445
82	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.05118915
83	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.04957459
84	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.04393361
85	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.03507282
86	LXR_22292898_ChIP-Seq_THP-1_Human	1.02781357
87	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.01695917
88	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.00114205
89	BCL6_27268052_Chip-Seq_Bcells_Human	0.98424841
90	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.98107168
91	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97678951
92	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.97117722
93	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.95788316
94	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.94755027
95	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.94736418
96	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.94642642
97	BCOR_27268052_Chip-Seq_Bcells_Human	0.94448004
98	MAF_26560356_Chip-Seq_TH2_Human	0.93827339
99	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.93680139
100	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.90392836

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	4.18767714
2	MP0005451_abnormal_body_composition	3.91893385
3	MP0010094_abnormal_chromosome_stability	3.75843379
4	MP0002822_catalepsy	3.67503885
5	MP0008058_abnormal_DNA_repair	3.64597902
6	MP0003111_abnormal_nucleus_morphology	3.35751314
7	MP0006035_abnormal_mitochondrial_morpho	2.99970038
8	MP0004957_abnormal_blastocyst_morpholog	2.83412888
9	MP0003077_abnormal_cell_cycle	2.75834028
10	MP0003806_abnormal_nucleotide_metabolis	2.57294868
11	MP0001529_abnormal_vocalization	2.40082105
12	MP0003718_maternal_effect	2.29263723
13	MP0009697_abnormal_copulation	2.28917864
14	MP0003786_premature_aging	2.25261810
15	MP0008932_abnormal_embryonic_tissue	2.17654543
16	MP0001764_abnormal_homeostasis	2.08203172
17	MP0006036_abnormal_mitochondrial_physio	2.06506066
18	MP0000358_abnormal_cell_content/	2.02036281
19	MP0000490_abnormal_crypts_of	1.98027741
20	MP0001730_embryonic_growth_arrest	1.93330347
21	MP0000013_abnormal_adipose_tissue	1.91806919
22	MP0002396_abnormal_hematopoietic_system	1.84819146
23	MP0005083_abnormal_biliary_tract	1.82660792
24	MP0001661_extended_life_span	1.78102837
25	MP0008260_abnormal_autophagy	1.69999733
26	MP0003315_abnormal_perineum_morphology	1.68935683
27	MP0002139_abnormal_hepatobiliary_system	1.68474076
28	MP0000003_abnormal_adipose_tissue	1.62190457
29	MP0000313_abnormal_cell_death	1.58415816
30	MP0008007_abnormal_cellular_replicative	1.51332931
31	MP0003186_abnormal_redox_activity	1.51122758
32	MP0009333_abnormal_splenocyte_physiolog	1.50164200
33	MP0000350_abnormal_cell_proliferation	1.40362243
34	MP0004233_abnormal_muscle_weight	1.39207888
35	MP0005501_abnormal_skin_physiology	1.38121873
36	MP0010030_abnormal_orbit_morphology	1.34011857
37	MP0005085_abnormal_gallbladder_physiolo	1.30528075
38	MP0003221_abnormal_cardiomyocyte_apopto	1.30402552
39	MP0005380_embryogenesis_phenotype	1.28796040
40	MP0001672_abnormal_embryogenesis/_devel	1.28796040
41	MP0002080_prenatal_lethality	1.28552731
42	MP0003984_embryonic_growth_retardation	1.26542155
43	MP0002210_abnormal_sex_determination	1.22111620
44	MP0008789_abnormal_olfactory_epithelium	1.19253338
45	MP0005365_abnormal_bile_salt	1.19066765
46	MP0001697_abnormal_embryo_size	1.17648539
47	MP0001929_abnormal_gametogenesis	1.16407596
48	MP0002088_abnormal_embryonic_growth/wei	1.14851391
49	MP0005645_abnormal_hypothalamus_physiol	1.13737932
50	MP0001145_abnormal_male_reproductive	1.11161701
51	MP0005499_abnormal_olfactory_system	1.09428748
52	MP0005394_taste/olfaction_phenotype	1.09428748
53	MP0002019_abnormal_tumor_incidence	1.09058811
54	MP0004808_abnormal_hematopoietic_stem	1.03013400
55	MP0005058_abnormal_lysosome_morphology	1.00180896
56	MP0005360_urolithiasis	0.99369177
57	MP0006292_abnormal_olfactory_placode	0.97869271
58	MP0000609_abnormal_liver_physiology	0.97831344
59	MP0002132_abnormal_respiratory_system	0.94289416
60	MP0002653_abnormal_ependyma_morphology	0.92170603
61	MP0000653_abnormal_sex_gland	0.92005337
62	MP0005319_abnormal_enzyme/_coenzyme	0.90705781
63	MP0004197_abnormal_fetal_growth/weight/	0.89342261
64	MP0002160_abnormal_reproductive_system	0.88089354
65	MP0004185_abnormal_adipocyte_glucose	0.86514447
66	MP0005646_abnormal_pituitary_gland	0.84404452
67	MP0004133_heterotaxia	0.84248915
68	MP0009672_abnormal_birth_weight	0.84203141
69	MP0005671_abnormal_response_to	0.84019468
70	MP0003656_abnormal_erythrocyte_physiolo	0.81900466
71	MP0000598_abnormal_liver_morphology	0.81772222
72	MP0004147_increased_porphyrin_level	0.80991125
73	MP0003698_abnormal_male_reproductive	0.80370792
74	MP0003123_paternal_imprinting	0.79377499
75	MP0005220_abnormal_exocrine_pancreas	0.79141084
76	MP0002089_abnormal_postnatal_growth/wei	0.79115681
77	MP0000689_abnormal_spleen_morphology	0.77951013
78	MP0008995_early_reproductive_senescence	0.77724279
79	MP0005367_renal/urinary_system_phenotyp	0.77493596
80	MP0000516_abnormal_urinary_system	0.77493596
81	MP0002796_impaired_skin_barrier	0.76991598
82	MP0002084_abnormal_developmental_patter	0.74932204
83	MP0005384_cellular_phenotype	0.73072505
84	MP0002722_abnormal_immune_system	0.70959571
85	MP0006276_abnormal_autonomic_nervous	0.70668239
86	MP0008875_abnormal_xenobiotic_pharmacok	0.68965862
87	MP0002161_abnormal_fertility/fecundity	0.68427760
88	MP0005075_abnormal_melanosome_morpholog	0.67953516
89	MP0003699_abnormal_female_reproductive	0.67803264
90	MP0002269_muscular_atrophy	0.67434950
91	MP0003567_abnormal_fetal_cardiomyocyte	0.67342534
92	MP0005332_abnormal_amino_acid	0.67149929
93	MP0002429_abnormal_blood_cell	0.65805249
94	MP0002086_abnormal_extraembryonic_tissu	0.65419391
95	MP0005389_reproductive_system_phenotype	0.64841223
96	MP0002085_abnormal_embryonic_tissue	0.64577320
97	MP0001188_hyperpigmentation	0.64298178
98	MP0001119_abnormal_female_reproductive	0.64183877
99	MP0002398_abnormal_bone_marrow	0.63999606
100	MP0002970_abnormal_white_adipose	0.63554752

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Microvesicular hepatic steatosis (HP:0001414)	4.32103790
2	Abnormality of glycolysis (HP:0004366)	3.85428530
3	Abnormal gallbladder physiology (HP:0012438)	3.81838922
4	Cholecystitis (HP:0001082)	3.81838922
5	Reticulocytopenia (HP:0001896)	3.63609222
6	Premature ovarian failure (HP:0008209)	3.55423175
7	Increased serum pyruvate (HP:0003542)	3.52061856
8	Ragged-red muscle fibers (HP:0003200)	3.39702445
9	Cerebral hypomyelination (HP:0006808)	3.22778192
10	Increased intramyocellular lipid droplets (HP:0012240)	3.17711080
11	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.11655172
12	Brushfield spots (HP:0001088)	3.03026916
13	Progressive muscle weakness (HP:0003323)	3.02183726
14	Increased muscle lipid content (HP:0009058)	2.99420724
15	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.95247690
16	Abnormal mitochondria in muscle tissue (HP:0008316)	2.94156006
17	Multiple enchondromatosis (HP:0005701)	2.93071158
18	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.90655658
19	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.90655658
20	Cerebral edema (HP:0002181)	2.88512435
21	Chromsome breakage (HP:0040012)	2.88093372
22	Acute encephalopathy (HP:0006846)	2.84195494
23	Hepatocellular necrosis (HP:0001404)	2.84165554
24	Horseshoe kidney (HP:0000085)	2.83406095
25	Reduced antithrombin III activity (HP:0001976)	2.83267831
26	Testicular atrophy (HP:0000029)	2.79828043
27	Abnormality of reticulocytes (HP:0004312)	2.78370618
28	Increased serum lactate (HP:0002151)	2.73520072
29	Lactic acidosis (HP:0003128)	2.70810389
30	Increased CSF lactate (HP:0002490)	2.68088599
31	Type I transferrin isoform profile (HP:0003642)	2.64591424
32	Secondary amenorrhea (HP:0000869)	2.61226389
33	Acute necrotizing encephalopathy (HP:0006965)	2.61183548
34	Mitochondrial inheritance (HP:0001427)	2.60108227
35	Abnormal number of erythroid precursors (HP:0012131)	2.58985354
36	Hyperglycinemia (HP:0002154)	2.58341586
37	Abnormality of DNA repair (HP:0003254)	2.57269115
38	Pancytopenia (HP:0001876)	2.55601428
39	Abnormal protein glycosylation (HP:0012346)	2.55164905
40	Abnormal glycosylation (HP:0012345)	2.55164905
41	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.55164905
42	Abnormal protein N-linked glycosylation (HP:0012347)	2.55164905
43	Rhabdomyolysis (HP:0003201)	2.54312714
44	Exercise intolerance (HP:0003546)	2.52655875
45	Bile duct proliferation (HP:0001408)	2.51757200
46	Abnormal biliary tract physiology (HP:0012439)	2.51757200
47	Hyperammonemia (HP:0001987)	2.49304087
48	Abnormality of pyrimidine metabolism (HP:0004353)	2.47438456
49	Hyperglycinuria (HP:0003108)	2.46814111
50	Hypergonadotropic hypogonadism (HP:0000815)	2.42108166
51	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.41855160
52	Dicarboxylic aciduria (HP:0003215)	2.41855160
53	Reticulocytosis (HP:0001923)	2.37994437
54	Emotional lability (HP:0000712)	2.37011147
55	Retinal dysplasia (HP:0007973)	2.36988909
56	Death in infancy (HP:0001522)	2.36713077
57	Hepatic necrosis (HP:0002605)	2.34475809
58	Lethargy (HP:0001254)	2.34209158
59	Abnormality of cells of the erythroid lineage (HP:0012130)	2.33908249
60	Cerebellar dysplasia (HP:0007033)	2.30163911
61	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.28057052
62	Opisthotonus (HP:0002179)	2.18230919
63	Epiphyseal stippling (HP:0010655)	2.17537266
64	CNS hypomyelination (HP:0003429)	2.16157346
65	Shoulder girdle muscle weakness (HP:0003547)	2.14994724
66	Rough bone trabeculation (HP:0100670)	2.12658158
67	Cholelithiasis (HP:0001081)	2.11526603
68	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.08951556
69	Lipid accumulation in hepatocytes (HP:0006561)	2.06351108
70	Proximal placement of thumb (HP:0009623)	2.06117010
71	Methylmalonic aciduria (HP:0012120)	2.05953362
72	Abnormal gallbladder morphology (HP:0012437)	2.04019712
73	Increased hepatocellular lipid droplets (HP:0006565)	2.03944291
74	Myopathic facies (HP:0002058)	2.00056288
75	Abnormality of fatty-acid metabolism (HP:0004359)	1.97796687
76	Spastic paraparesis (HP:0002313)	1.97525130
77	IgM deficiency (HP:0002850)	1.95738217
78	Entropion (HP:0000621)	1.95615918
79	Impulsivity (HP:0100710)	1.95586128
80	Gout (HP:0001997)	1.92549439
81	Squamous cell carcinoma (HP:0002860)	1.92049956
82	Abnormality of glycine metabolism (HP:0010895)	1.91511224
83	Abnormality of serine family amino acid metabolism (HP:0010894)	1.91511224
84	Abnormality of the gallbladder (HP:0005264)	1.88670359
85	Trismus (HP:0000211)	1.87279429
86	Myoglobinuria (HP:0002913)	1.86709000
87	Thrombocytosis (HP:0001894)	1.85185431
88	Progressive macrocephaly (HP:0004481)	1.83553179
89	Breast hypoplasia (HP:0003187)	1.80904447
90	Postnatal microcephaly (HP:0005484)	1.79919049
91	CNS demyelination (HP:0007305)	1.78365461
92	Hand muscle atrophy (HP:0009130)	1.78186541
93	Deviation of the thumb (HP:0009603)	1.77388727
94	Respiratory difficulties (HP:0002880)	1.74169163
95	Aplastic anemia (HP:0001915)	1.73010924
96	Abnormality of the ileum (HP:0001549)	1.72288880
97	Meckel diverticulum (HP:0002245)	1.69479053
98	Panhypogammaglobulinemia (HP:0003139)	1.68546695
99	Abnormality of the preputium (HP:0100587)	1.68307181
100	Progressive external ophthalmoplegia (HP:0000590)	1.67242463

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	4.60912824
2	SRPK1	4.09661476
3	NME2	3.67501108
4	BUB1	3.56603462
5	PDK2	3.43235501
6	VRK2	3.23792395
7	PBK	3.00975959
8	TESK2	2.91705002
9	MAP4K2	2.81473253
10	PIM2	2.56324332
11	TRIM28	2.05576567
12	TTK	1.95188272
13	EIF2AK1	1.87399953
14	ERN1	1.85910144
15	KDR	1.81752225
16	TESK1	1.73005790
17	CDC7	1.68019940
18	SMG1	1.67308536
19	IRAK3	1.62670650
20	MST1R	1.58026574
21	MAP2K7	1.43045145
22	CDK19	1.40700539
23	MAP4K1	1.39242965
24	EPHB1	1.28302263
25	RPS6KA4	1.26045165
26	ZAK	1.22929258
27	AURKA	1.22568986
28	ATR	1.11757271
29	AURKB	1.10200189
30	TAOK2	1.07313219
31	STK16	1.06924221
32	CHEK2	1.05513988
33	SCYL2	1.03704040
34	CDK4	1.03342772
35	AKT2	1.01691535
36	MATK	0.97336705
37	TSSK6	0.97280796
38	PLK1	0.96787241
39	CDK7	0.94253359
40	PAK4	0.94003557
41	ICK	0.92629421
42	DYRK3	0.90296241
43	PRPF4B	0.89107968
44	SIK1	0.88393947
45	MAP3K11	0.87560693
46	EEF2K	0.86609755
47	CSNK1G3	0.86151658
48	CHEK1	0.82166825
49	NME1	0.81927038
50	NEK1	0.81007378
51	CCNB1	0.79711798
52	CDK9	0.78162977
53	RPS6KB2	0.74051587
54	MAP3K8	0.73700778
55	MAP3K10	0.72683334
56	VRK1	0.72454884
57	PIM1	0.70004558
58	MAPK11	0.69883982
59	CDK6	0.68235184
60	ARAF	0.65714486
61	LMTK2	0.64213877
62	RPS6KA5	0.64186849
63	MAP3K5	0.63700948
64	GRK6	0.61939192
65	TBK1	0.61893809
66	EPHA2	0.61177267
67	PLK4	0.60195345
68	DAPK1	0.59590578
69	CSNK1A1L	0.59327518
70	MKNK1	0.57702031
71	RAF1	0.57114408
72	DYRK1B	0.55214426
73	CSNK1G1	0.50703693
74	CDK2	0.50095360
75	EPHA4	0.49724933
76	JAK3	0.47341293
77	CSNK2A1	0.46027110
78	STK10	0.45631090
79	TLK1	0.45253252
80	CSNK2A2	0.44561062
81	MAP2K3	0.43715190
82	DYRK2	0.43142630
83	FLT3	0.42837010
84	BRAF	0.42288761
85	MAP3K6	0.40546906
86	PRKD2	0.40133311
87	CDK12	0.38830317
88	SIK3	0.37329900
89	CDK11A	0.37146304
90	PRKCI	0.37128807
91	MAPKAPK5	0.36914272
92	MAPKAPK3	0.36245370
93	BMX	0.36110444
94	PAK1	0.34882680
95	CDK14	0.33240731
96	ATM	0.33211000
97	CSNK1G2	0.30555332
98	CDK8	0.30291811
99	MUSK	0.30182960
100	CDK1	0.29789441

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.08314145
2	Base excision repair_Homo sapiens_hsa03410	3.06387198
3	DNA replication_Homo sapiens_hsa03030	3.00382553
4	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.67069200
5	Proteasome_Homo sapiens_hsa03050	2.54073169
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.51317024
7	RNA polymerase_Homo sapiens_hsa03020	2.41973426
8	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.32305729
9	Spliceosome_Homo sapiens_hsa03040	2.18952826
10	Steroid biosynthesis_Homo sapiens_hsa00100	2.18120997
11	Ribosome_Homo sapiens_hsa03010	2.17677539
12	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.17470145
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.17073156
14	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.16790390
15	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.16013989
16	Sulfur relay system_Homo sapiens_hsa04122	2.12277703
17	Mismatch repair_Homo sapiens_hsa03430	2.06281168
18	Homologous recombination_Homo sapiens_hsa03440	1.96809731
19	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.95601908
20	Carbon metabolism_Homo sapiens_hsa01200	1.92412279
21	Pentose phosphate pathway_Homo sapiens_hsa00030	1.91209988
22	RNA transport_Homo sapiens_hsa03013	1.89662082
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.88824066
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.87835153
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.78269974
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.77548868
27	Arginine biosynthesis_Homo sapiens_hsa00220	1.74934053
28	Parkinsons disease_Homo sapiens_hsa05012	1.73932218
29	Oxidative phosphorylation_Homo sapiens_hsa00190	1.68340025
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.62540401
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.58421778
32	Pyruvate metabolism_Homo sapiens_hsa00620	1.57176597
33	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.57032511
34	One carbon pool by folate_Homo sapiens_hsa00670	1.56113250
35	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.55549091
36	Fatty acid elongation_Homo sapiens_hsa00062	1.51425593
37	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.37913031
38	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.25412476
39	Basal transcription factors_Homo sapiens_hsa03022	1.23630880
40	Huntingtons disease_Homo sapiens_hsa05016	1.22805393
41	Folate biosynthesis_Homo sapiens_hsa00790	1.22800249
42	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.19395974
43	Phenylalanine metabolism_Homo sapiens_hsa00360	1.18119208
44	Cell cycle_Homo sapiens_hsa04110	1.16713386
45	Purine metabolism_Homo sapiens_hsa00230	1.12724519
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11052874
47	RNA degradation_Homo sapiens_hsa03018	1.10061478
48	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.06504002
49	Arginine and proline metabolism_Homo sapiens_hsa00330	1.04064690
50	Galactose metabolism_Homo sapiens_hsa00052	1.02180332
51	Peroxisome_Homo sapiens_hsa04146	0.98916706
52	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.97888426
53	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.93845016
54	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.89069155
55	mRNA surveillance pathway_Homo sapiens_hsa03015	0.88668977
56	Metabolic pathways_Homo sapiens_hsa01100	0.86351310
57	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.86009727
58	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.85862825
59	Primary immunodeficiency_Homo sapiens_hsa05340	0.84944042
60	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.81039998
61	Propanoate metabolism_Homo sapiens_hsa00640	0.80172609
62	Glutathione metabolism_Homo sapiens_hsa00480	0.78672024
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.75761485
64	Selenocompound metabolism_Homo sapiens_hsa00450	0.75072090
65	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.74330401
66	Fatty acid metabolism_Homo sapiens_hsa01212	0.72497824
67	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.71387749
68	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.70267953
69	Alzheimers disease_Homo sapiens_hsa05010	0.66534161
70	Protein export_Homo sapiens_hsa03060	0.64910274
71	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.62599457
72	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.61501684
73	Vibrio cholerae infection_Homo sapiens_hsa05110	0.55775754
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43954999
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41271749
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.39845792
77	p53 signaling pathway_Homo sapiens_hsa04115	0.39553394
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.39511723
79	Viral carcinogenesis_Homo sapiens_hsa05203	0.39266700
80	Herpes simplex infection_Homo sapiens_hsa05168	0.35925426
81	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.35842144
82	Sulfur metabolism_Homo sapiens_hsa00920	0.35542696
83	Lysosome_Homo sapiens_hsa04142	0.29231598
84	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.28251059
85	Shigellosis_Homo sapiens_hsa05131	0.27339791
86	Tyrosine metabolism_Homo sapiens_hsa00350	0.26292135
87	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.24568020
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.24521951
89	Apoptosis_Homo sapiens_hsa04210	0.24078939
90	Bladder cancer_Homo sapiens_hsa05219	0.22239972
91	Oocyte meiosis_Homo sapiens_hsa04114	0.21552803
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.20347216
93	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.15329972
94	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.14147332
95	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.13859530
96	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.12237362
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.11281175
98	Hepatitis B_Homo sapiens_hsa05161	0.10157322
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.09329135
100	HTLV-I infection_Homo sapiens_hsa05166	0.08733223

POLRMTP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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