POM121B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tolerance induction (GO:0002507)6.71534356
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.66705829
3positive T cell selection (GO:0043368)5.41617595
4negative T cell selection (GO:0043383)5.16553964
5regulation of isotype switching to IgG isotypes (GO:0048302)5.02980465
6positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.65105311
7negative regulation of cAMP-mediated signaling (GO:0043951)4.59272494
8T cell selection (GO:0045058)4.57550768
9positive regulation of granulocyte differentiation (GO:0030854)4.55408195
10negative thymic T cell selection (GO:0045060)4.48973251
11RNA destabilization (GO:0050779)4.42641424
12thymic T cell selection (GO:0045061)4.34672941
13positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO4.32519650
14regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)4.32519650
15positive regulation of interleukin-4 production (GO:0032753)4.30851889
16regulation of B cell receptor signaling pathway (GO:0050855)4.20434708
17positive regulation by host of viral transcription (GO:0043923)4.20221453
18regulation of gamma-delta T cell differentiation (GO:0045586)4.18653821
19regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)4.17017553
20positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)4.17017553
21regulation of interleukin-2 biosynthetic process (GO:0045076)4.16719828
22alpha-beta T cell differentiation (GO:0046632)4.14316947
23regulation of interleukin-4 production (GO:0032673)4.13486679
24mast cell activation (GO:0045576)4.09905392
25N-terminal protein amino acid acetylation (GO:0006474)4.05113912
26positive regulation of tolerance induction (GO:0002645)4.00154854
27positive regulation of mRNA catabolic process (GO:0061014)3.86538873
28alpha-beta T cell activation (GO:0046631)3.80944419
29positive regulation of T cell differentiation in thymus (GO:0033089)3.71221582
30positive thymic T cell selection (GO:0045059)3.69448331
31NIK/NF-kappaB signaling (GO:0038061)3.60172424
32regulation of isotype switching (GO:0045191)3.57938475
33regulation of T cell tolerance induction (GO:0002664)3.57003397
34regulation of gamma-delta T cell activation (GO:0046643)3.55021962
35regulation of mRNA catabolic process (GO:0061013)3.51850472
36CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.51356472
37lymph node development (GO:0048535)3.50848239
38V(D)J recombination (GO:0033151)3.50645939
39positive regulation of gamma-delta T cell activation (GO:0046645)3.47710177
40hypothalamus development (GO:0021854)3.46846229
41Peyers patch development (GO:0048541)3.44426009
42mucosal-associated lymphoid tissue development (GO:0048537)3.44426009
43positive regulation of keratinocyte differentiation (GO:0045618)3.44413029
44negative regulation of calcium ion transport into cytosol (GO:0010523)3.41334789
45CD4-positive, alpha-beta T cell activation (GO:0035710)3.34691443
46interferon-gamma production (GO:0032609)3.33589724
47T cell differentiation (GO:0030217)3.30678107
48T cell receptor signaling pathway (GO:0050852)3.29686040
49mitochondrial calcium ion transport (GO:0006851)3.26247267
50mast cell activation involved in immune response (GO:0002279)3.21400713
51mast cell degranulation (GO:0043303)3.21400713
52mature B cell differentiation (GO:0002335)3.16644846
53antigen receptor-mediated signaling pathway (GO:0050851)3.14800048
54positive regulation of DNA recombination (GO:0045911)3.13766068
55positive regulation of mRNA 3-end processing (GO:0031442)3.11937311
56regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.10214722
57cellular response to interleukin-15 (GO:0071350)3.09308984
58regulation of granulocyte differentiation (GO:0030852)3.09211918
59B cell receptor signaling pathway (GO:0050853)3.07544202
60T-helper cell differentiation (GO:0042093)3.06420894
61CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.06420894
62positive regulation of interleukin-17 production (GO:0032740)3.03175888
63positive regulation of isotype switching (GO:0045830)3.02103499
64mature B cell differentiation involved in immune response (GO:0002313)3.00833110
65positive regulation of interleukin-2 production (GO:0032743)2.91190162
66negative regulation of histone acetylation (GO:0035067)2.90177171
67viral protein processing (GO:0019082)2.90141056
68N-terminal protein amino acid modification (GO:0031365)2.89179528
69regulation of tolerance induction (GO:0002643)2.88539662
70regulation of regulatory T cell differentiation (GO:0045589)2.87604999
71megakaryocyte development (GO:0035855)2.87327307
72regulation of interleukin-5 production (GO:0032674)2.86588327
73signal peptide processing (GO:0006465)2.84739554
74histone deubiquitination (GO:0016578)2.84542675
753-UTR-mediated mRNA stabilization (GO:0070935)2.83649524
76response to interleukin-15 (GO:0070672)2.83423380
77positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.83061519
78negative regulation of B cell mediated immunity (GO:0002713)2.82365668
79negative regulation of immunoglobulin mediated immune response (GO:0002890)2.82365668
80embryonic hemopoiesis (GO:0035162)2.81933270
81response to pheromone (GO:0019236)2.81521079
82T cell migration (GO:0072678)2.80574782
83regulation of interleukin-2 production (GO:0032663)2.78230087
84developmental pigmentation (GO:0048066)2.77687749
85negative regulation of execution phase of apoptosis (GO:1900118)2.77673395
86activated T cell proliferation (GO:0050798)2.77006317
87positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.73327255
88leukocyte aggregation (GO:0070486)2.72387947
89regulation of T cell receptor signaling pathway (GO:0050856)2.71619612
90embryonic process involved in female pregnancy (GO:0060136)2.69262403
91negative regulation of production of molecular mediator of immune response (GO:0002701)2.67988763
92negative regulation of cytokine production involved in immune response (GO:0002719)2.67597094
93protein K63-linked deubiquitination (GO:0070536)2.67291631
94T cell activation (GO:0042110)2.67131826
95alpha-beta T cell differentiation involved in immune response (GO:0002293)2.65768720
96alpha-beta T cell activation involved in immune response (GO:0002287)2.65768720
97T cell differentiation involved in immune response (GO:0002292)2.65768720
98negative regulation of peptidyl-lysine acetylation (GO:2000757)2.65603925
99T cell homeostasis (GO:0043029)2.63814471
100histone H4 acetylation (GO:0043967)2.63514862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.41183927
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.04757913
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.37337804
4RUNX_20019798_ChIP-Seq_JUKART_Human4.16378416
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.79561734
6MYC_22102868_ChIP-Seq_BL_Human3.64364970
7MYB_26560356_Chip-Seq_TH2_Human3.32518405
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.08665300
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.00951142
10MAF_26560356_Chip-Seq_TH1_Human2.75970355
11MYB_26560356_Chip-Seq_TH1_Human2.69430265
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.69137771
13CIITA_25753668_ChIP-Seq_RAJI_Human2.61923288
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.60500993
15UTX_26944678_Chip-Seq_JUKART_Human2.54964693
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.52439248
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.48799576
18SCL_19346495_ChIP-Seq_HPC-7_Human2.41732140
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.36723631
20MAF_26560356_Chip-Seq_TH2_Human2.25825879
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15772702
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.09042072
23VDR_21846776_ChIP-Seq_THP-1_Human2.02859016
24GATA3_27048872_Chip-Seq_THYMUS_Human2.02196301
25VDR_23849224_ChIP-Seq_CD4+_Human2.00921440
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96252601
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.95328426
28TCF7_22412390_ChIP-Seq_EML_Mouse1.94138937
29KDM2B_26808549_Chip-Seq_DND41_Human1.92515533
30VDR_24763502_ChIP-Seq_THP-1_Human1.81690046
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71179941
32TFEB_21752829_ChIP-Seq_HELA_Human1.67803547
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.67304930
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66506782
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63220557
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59530263
37SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58618875
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.57064585
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55581280
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.53695356
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52660312
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51229292
43FOXP3_21729870_ChIP-Seq_TREG_Human1.49973582
44SPI1_23547873_ChIP-Seq_NB4_Human1.49503573
45GATA3_26560356_Chip-Seq_TH2_Human1.47018722
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42128539
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41469961
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41218111
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38809137
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.35513867
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35344208
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.30941351
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30626256
54SPI1_23127762_ChIP-Seq_K562_Human1.28026784
55GATA1_22025678_ChIP-Seq_K562_Human1.27499456
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.25769786
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.21865238
58FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18218792
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17636070
60GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17604584
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.15636053
62PKCTHETA_26484144_Chip-Seq_BREAST_Human1.14714912
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14572661
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13402106
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12922968
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11968971
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11711209
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05984784
69RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05488875
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.03305585
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02824523
72DCP1A_22483619_ChIP-Seq_HELA_Human1.02293863
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01310202
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00943429
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00730230
76GABP_17652178_ChIP-ChIP_JURKAT_Human0.99874477
77IRF8_27001747_Chip-Seq_BMDM_Mouse0.99544584
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98615759
79RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97984473
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97896196
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97896196
82KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97896196
83VDR_24787735_ChIP-Seq_THP-1_Human0.97625061
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97101068
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96977282
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96337298
87IRF8_21731497_ChIP-ChIP_J774_Mouse0.95508430
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94472482
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93893479
90BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93336945
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91862794
92NCOR1_26117541_ChIP-Seq_K562_Human0.89871237
93YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88004840
94GATA3_26560356_Chip-Seq_TH1_Human0.86905195
95TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.86750718
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85634240
97BCL6_27268052_Chip-Seq_Bcells_Human0.79245451
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77735026
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76034186
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.75269659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.47145938
2MP0003763_abnormal_thymus_physiology4.34874298
3MP0008057_abnormal_DNA_replication4.10901672
4MP0005451_abnormal_body_composition4.07047078
5MP0005075_abnormal_melanosome_morpholog3.02750574
6MP0005671_abnormal_response_to2.93457672
7MP0001873_stomach_inflammation2.84091270
8MP0009333_abnormal_splenocyte_physiolog2.67190343
9MP0008995_early_reproductive_senescence2.62314414
10MP0000703_abnormal_thymus_morphology2.59604118
11MP0002166_altered_tumor_susceptibility2.56440419
12MP0003300_gastrointestinal_ulcer2.56384557
13MP0004381_abnormal_hair_follicle2.42211848
14MP0005379_endocrine/exocrine_gland_phen2.33261464
15MP0002163_abnormal_gland_morphology2.07473814
16MP0003436_decreased_susceptibility_to2.06667717
17MP0005000_abnormal_immune_tolerance2.06641354
18MP0002398_abnormal_bone_marrow2.02591854
19MP0001800_abnormal_humoral_immune1.92909360
20MP0000685_abnormal_immune_system1.88172458
21MP0002405_respiratory_system_inflammati1.86380655
22MP0002722_abnormal_immune_system1.85174304
23MP0002420_abnormal_adaptive_immunity1.82814851
24MP0000689_abnormal_spleen_morphology1.82404836
25MP0000716_abnormal_immune_system1.81746211
26MP0002723_abnormal_immune_serum1.80607808
27MP0005645_abnormal_hypothalamus_physiol1.78090852
28MP0001819_abnormal_immune_cell1.77671181
29MP0002877_abnormal_melanocyte_morpholog1.75821123
30MP0005387_immune_system_phenotype1.72316811
31MP0001790_abnormal_immune_system1.72316811
32MP0002396_abnormal_hematopoietic_system1.63411546
33MP0000465_gastrointestinal_hemorrhage1.57677829
34MP0000372_irregular_coat_pigmentation1.57064219
35MP0003866_abnormal_defecation1.56929359
36MP0003693_abnormal_embryo_hatching1.55220860
37MP0008961_abnormal_basal_metabolism1.54562592
38MP0008877_abnormal_DNA_methylation1.53405588
39MP0003183_abnormal_peptide_metabolism1.52027094
40MP0001835_abnormal_antigen_presentation1.50543266
41MP0004808_abnormal_hematopoietic_stem1.48263515
42MP0001851_eye_inflammation1.47893846
43MP0002006_tumorigenesis1.45467873
44MP0004947_skin_inflammation1.45203218
45MP0002452_abnormal_antigen_presenting1.44509175
46MP0002876_abnormal_thyroid_physiology1.42651584
47MP0002429_abnormal_blood_cell1.42560656
48MP0000015_abnormal_ear_pigmentation1.36756820
49MP0003786_premature_aging1.33797367
50MP0005310_abnormal_salivary_gland1.22553679
51MP0002933_joint_inflammation1.20786999
52MP0004142_abnormal_muscle_tone1.09368921
53MP0005647_abnormal_sex_gland1.02822623
54MP0003045_fibrosis1.01313033
55MP0002148_abnormal_hypersensitivity_rea0.95842943
56MP0009115_abnormal_fat_cell0.95618628
57MP0005025_abnormal_response_to0.90881452
58MP0005377_hearing/vestibular/ear_phenot0.90402971
59MP0003878_abnormal_ear_physiology0.90402971
60MP0002998_abnormal_bone_remodeling0.90395266
61MP0008058_abnormal_DNA_repair0.90154408
62MP0003111_abnormal_nucleus_morphology0.89624538
63MP0001270_distended_abdomen0.87971644
64MP0002019_abnormal_tumor_incidence0.86933337
65MP0001845_abnormal_inflammatory_respons0.86742278
66MP0006082_CNS_inflammation0.85261751
67MP0002419_abnormal_innate_immunity0.83110107
68MP0000490_abnormal_crypts_of0.80421155
69MP0002168_other_aberrant_phenotype0.79554376
70MP0003172_abnormal_lysosome_physiology0.77211154
71MP0009278_abnormal_bone_marrow0.76246006
72MP0005670_abnormal_white_adipose0.75582897
73MP0001879_abnormal_lymphatic_vessel0.73304322
74MP0002095_abnormal_skin_pigmentation0.72857145
75MP0003943_abnormal_hepatobiliary_system0.72651980
76MP0003646_muscle_fatigue0.70214637
77MP0005266_abnormal_metabolism0.68837159
78MP0001905_abnormal_dopamine_level0.68229704
79MP0004957_abnormal_blastocyst_morpholog0.68216894
80MP0001661_extended_life_span0.67347964
81MP0001764_abnormal_homeostasis0.66751335
82MP0003195_calcinosis0.64926492
83MP0000371_diluted_coat_color0.64263948
84MP0001784_abnormal_fluid_regulation0.63927166
85MP0003656_abnormal_erythrocyte_physiolo0.62922524
86MP0001727_abnormal_embryo_implantation0.62258673
87MP0008004_abnormal_stomach_pH0.61054678
88MP0001853_heart_inflammation0.60062767
89MP0010155_abnormal_intestine_physiology0.58788791
90MP0003077_abnormal_cell_cycle0.58518485
91MP0005076_abnormal_cell_differentiation0.58004287
92MP0005410_abnormal_fertilization0.56093021
93MP0005646_abnormal_pituitary_gland0.55812599
94MP0004134_abnormal_chest_morphology0.54143023
95MP0001919_abnormal_reproductive_system0.53771475
96MP0001545_abnormal_hematopoietic_system0.53242588
97MP0005397_hematopoietic_system_phenotyp0.53242588
98MP0000313_abnormal_cell_death0.49708935
99MP0004742_abnormal_vestibular_system0.49353406
100MP0009785_altered_susceptibility_to0.48951151

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.35454436
2Severe combined immunodeficiency (HP:0004430)4.34128194
3Amyotrophic lateral sclerosis (HP:0007354)3.84354488
4Impaired proprioception (HP:0010831)3.82970526
5Thyroiditis (HP:0100646)3.72688835
6Autoimmune hemolytic anemia (HP:0001890)3.54436053
7T lymphocytopenia (HP:0005403)3.49308952
8Anhidrosis (HP:0000970)3.44657199
9Tongue fasciculations (HP:0001308)3.36071458
10Spondylolisthesis (HP:0003302)3.35130670
11Combined immunodeficiency (HP:0005387)3.27195296
12Abnormality of T cell number (HP:0011839)3.17750620
13Abnormality of T cells (HP:0002843)3.10530816
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.10053497
15Joint swelling (HP:0001386)3.01438313
16IgM deficiency (HP:0002850)2.91494312
17Recurrent viral infections (HP:0004429)2.90613323
18Neonatal respiratory distress (HP:0002643)2.89152503
19Abnormality of T cell physiology (HP:0011840)2.88460228
20Panhypogammaglobulinemia (HP:0003139)2.85269251
21Muscle fibrillation (HP:0010546)2.82665163
22Abnormality of eosinophils (HP:0001879)2.80833763
23Granulocytopenia (HP:0001913)2.79514965
24Slow saccadic eye movements (HP:0000514)2.79323538
25Hypokinesia (HP:0002375)2.77461144
26Urethral obstruction (HP:0000796)2.75616701
27Thickened calvaria (HP:0002684)2.71403923
28Pustule (HP:0200039)2.68693579
29Abnormality of the columella (HP:0009929)2.67543667
30Severe visual impairment (HP:0001141)2.66841226
31Type I diabetes mellitus (HP:0100651)2.65617271
32Eosinophilia (HP:0001880)2.58933919
33Lymphopenia (HP:0001888)2.55791253
34Hypoplasia of the thymus (HP:0000778)2.49576916
35Ulnar claw (HP:0001178)2.45685872
36Elevated erythrocyte sedimentation rate (HP:0003565)2.44300134
37Hypoplastic iliac wings (HP:0002866)2.41499309
38B lymphocytopenia (HP:0010976)2.39350869
39Supernumerary bones of the axial skeleton (HP:0009144)2.38281782
40Syringomyelia (HP:0003396)2.37651392
41Spinal cord lesions (HP:0100561)2.37651392
42Abnormality of cells of the lymphoid lineage (HP:0012140)2.34485661
43Agammaglobulinemia (HP:0004432)2.31293587
44Abnormality of hair growth rate (HP:0011363)2.30517854
45Slow-growing hair (HP:0002217)2.30517854
46Aplasia/Hypoplasia of the thymus (HP:0010515)2.29774959
47Prominent nose (HP:0000448)2.27657989
48Entropion (HP:0000621)2.27374758
49Inflammation of the large intestine (HP:0002037)2.24431946
50Mediastinal lymphadenopathy (HP:0100721)2.24059644
51Abnormality of the parathyroid morphology (HP:0011766)2.23394123
52Gastrointestinal inflammation (HP:0004386)2.23301730
53Abnormality of B cell number (HP:0010975)2.22843079
54Reduced subcutaneous adipose tissue (HP:0003758)2.22572662
55Degeneration of anterior horn cells (HP:0002398)2.22427623
56Abnormality of the anterior horn cell (HP:0006802)2.22427623
57Supernumerary ribs (HP:0005815)2.19393332
58Narrow palate (HP:0000189)2.18435466
59Congenital stationary night blindness (HP:0007642)2.17881656
60Increased density of long bones (HP:0006392)2.16729086
61Abnormality of macular pigmentation (HP:0008002)2.14108896
62Spontaneous hematomas (HP:0007420)2.10308293
63Increased CSF protein (HP:0002922)2.08846033
64Increased IgE level (HP:0003212)2.07785986
65Leukocytosis (HP:0001974)2.07087778
66Deep palmar crease (HP:0006191)2.04727253
67Homocystinuria (HP:0002156)2.02921623
68Abnormality of homocysteine metabolism (HP:0010919)2.02921623
69Bicuspid aortic valve (HP:0001647)2.02640074
70Abnormality of the left ventricular outflow tract (HP:0011103)2.00575100
71Subaortic stenosis (HP:0001682)2.00575100
72Meningitis (HP:0001287)1.99769619
73Abnormality of the fingertips (HP:0001211)1.98620241
74Recurrent fungal infections (HP:0002841)1.98414984
75Broad alveolar ridges (HP:0000187)1.95209174
76Abnormality of the fovea (HP:0000493)1.94197034
77Atrophy/Degeneration involving motor neurons (HP:0007373)1.94029391
78Conjunctival telangiectasia (HP:0000524)1.93540137
79Albinism (HP:0001022)1.93488970
80Pulmonary fibrosis (HP:0002206)1.92780904
81Horizontal nystagmus (HP:0000666)1.90998560
82Loss of speech (HP:0002371)1.90501893
83IgG deficiency (HP:0004315)1.89915988
84Progressive muscle weakness (HP:0003323)1.89436872
85Abnormality of the prostate (HP:0008775)1.88547275
86Abnormality of ocular smooth pursuit (HP:0000617)1.87820592
87Submucous cleft hard palate (HP:0000176)1.86535113
88Hypergammaglobulinemia (HP:0010702)1.86511904
89Lymphoma (HP:0002665)1.85313203
90Ocular albinism (HP:0001107)1.83361851
91Easy fatigability (HP:0003388)1.83340779
92Abnormality of binocular vision (HP:0011514)1.82821461
93Diplopia (HP:0000651)1.82821461
94Broad ribs (HP:0000885)1.80757088
95Hypophosphatemic rickets (HP:0004912)1.79657474
96Central scotoma (HP:0000603)1.75525152
97Poikiloderma (HP:0001029)1.73777296
98Premature skin wrinkling (HP:0100678)1.73720610
99Abnormality of the lower motor neuron (HP:0002366)1.73088577
100Broad face (HP:0000283)1.72461154

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.72372499
2CDK124.31606491
3TXK3.71128252
4CAMKK22.95657209
5GRK62.89152688
6MAP3K102.77331098
7MAP4K22.46948029
8MUSK2.27314333
9PRPF4B2.20405290
10BRD42.13241890
11NLK2.10453956
12CAMK1D2.07382347
13IKBKE1.93495933
14ITK1.75650435
15BTK1.72809675
16SCYL21.70228047
17CAMK41.68644192
18KDR1.63684257
19NME21.49165867
20MAPKAPK31.40199410
21AKT31.37994986
22TEC1.36238338
23CDK61.35181606
24CDK41.33012683
25SIK31.26699677
26CAMKK11.24735328
27HIPK21.23687344
28SYK1.17505808
29STK161.10028768
30PRKD31.09598015
31STK101.08813621
32TLK11.08291079
33LCK1.03960139
34RPS6KA41.00868718
35MAP3K60.99454910
36MAP3K130.99104473
37PASK0.98830034
38TNK20.96962596
39IKBKB0.96944878
40CDK30.95548595
41ARAF0.91112086
42PRKD20.85795421
43HCK0.84691418
44TGFBR20.84598763
45CHUK0.81280138
46MAP3K140.81279806
47VRK20.81188914
48CSNK1G30.80370434
49TAOK10.79764373
50TESK20.77956098
51ZAP700.77933535
52CAMK1G0.77669779
53PDK10.76726195
54CAMK10.74793993
55MOS0.73634134
56MAP2K30.72785640
57DYRK30.72542374
58RIPK40.71761763
59MAPK110.71314794
60IRAK40.68240819
61IRAK30.66201056
62TAOK30.66177836
63IRAK10.64566119
64CDK90.63984965
65SIK10.63580088
66CSNK1G10.62604817
67PINK10.62244221
68STK380.61511738
69FLT30.61293925
70ADRBK20.61252104
71CSNK1A1L0.61102068
72FRK0.60511451
73BLK0.60075965
74FES0.59676507
75MTOR0.59657716
76IRAK20.58717066
77ERN10.57843021
78MAP2K20.57158925
79PRKCQ0.57104901
80MAP3K90.56990496
81JAK10.56041154
82MAPK70.55446739
83PIM10.54719261
84INSRR0.52882500
85SIK20.52745361
86PIK3CG0.52496924
87LRRK20.51233750
88LYN0.48658159
89MAPK120.48454177
90TBK10.48064306
91PKN20.47405044
92MAP3K110.45921811
93STK240.44649401
94BRAF0.44128251
95SMG10.42658348
96MAPK30.40716119
97SGK30.40194969
98UHMK10.39819389
99JAK30.38639630
100MAPKAPK20.37888904

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.68924909
2T cell receptor signaling pathway_Homo sapiens_hsa046603.57831634
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.56578021
4RNA polymerase_Homo sapiens_hsa030202.54158891
5B cell receptor signaling pathway_Homo sapiens_hsa046622.30994863
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.21772690
7Measles_Homo sapiens_hsa051622.18686376
8Non-small cell lung cancer_Homo sapiens_hsa052232.14165574
9Osteoclast differentiation_Homo sapiens_hsa043801.99815153
10Acute myeloid leukemia_Homo sapiens_hsa052211.97840611
11Selenocompound metabolism_Homo sapiens_hsa004501.97136204
12Colorectal cancer_Homo sapiens_hsa052101.95688845
13Ribosome_Homo sapiens_hsa030101.77505934
14Hepatitis B_Homo sapiens_hsa051611.71379655
15Basal transcription factors_Homo sapiens_hsa030221.69192954
16Hematopoietic cell lineage_Homo sapiens_hsa046401.62206776
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54966492
18Notch signaling pathway_Homo sapiens_hsa043301.53970369
19Chronic myeloid leukemia_Homo sapiens_hsa052201.44325451
20Base excision repair_Homo sapiens_hsa034101.42625730
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.42099696
22Herpes simplex infection_Homo sapiens_hsa051681.40506526
23Pancreatic cancer_Homo sapiens_hsa052121.40037982
24Prostate cancer_Homo sapiens_hsa052151.39125308
25HTLV-I infection_Homo sapiens_hsa051661.30339247
26FoxO signaling pathway_Homo sapiens_hsa040681.27079864
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.24250901
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23327262
29Endometrial cancer_Homo sapiens_hsa052131.23013057
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22381135
31mTOR signaling pathway_Homo sapiens_hsa041501.20105888
32Epstein-Barr virus infection_Homo sapiens_hsa051691.17175503
33Thyroid cancer_Homo sapiens_hsa052161.16659628
34Renal cell carcinoma_Homo sapiens_hsa052111.14665526
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13342197
36Dorso-ventral axis formation_Homo sapiens_hsa043201.12465582
37Spliceosome_Homo sapiens_hsa030401.10698932
38Viral carcinogenesis_Homo sapiens_hsa052031.06847612
39Non-homologous end-joining_Homo sapiens_hsa034500.99869994
40MAPK signaling pathway_Homo sapiens_hsa040100.92777710
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91094351
42TNF signaling pathway_Homo sapiens_hsa046680.90890420
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90632693
44Cell cycle_Homo sapiens_hsa041100.89035201
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87641719
46Collecting duct acid secretion_Homo sapiens_hsa049660.87544014
47Circadian rhythm_Homo sapiens_hsa047100.86528063
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.86094567
49Influenza A_Homo sapiens_hsa051640.85909029
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.84711604
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84695056
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83977577
53VEGF signaling pathway_Homo sapiens_hsa043700.83662623
54Malaria_Homo sapiens_hsa051440.82073267
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81535531
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79359311
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75856036
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75534243
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.74883387
60RNA transport_Homo sapiens_hsa030130.73960183
61Cocaine addiction_Homo sapiens_hsa050300.72910208
62Vibrio cholerae infection_Homo sapiens_hsa051100.72200832
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72119338
64Pyrimidine metabolism_Homo sapiens_hsa002400.71474648
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70513427
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68102854
67ABC transporters_Homo sapiens_hsa020100.66869856
68Leishmaniasis_Homo sapiens_hsa051400.66372954
69Lysine degradation_Homo sapiens_hsa003100.66016711
70Adherens junction_Homo sapiens_hsa045200.65227965
71Rheumatoid arthritis_Homo sapiens_hsa053230.63501338
72mRNA surveillance pathway_Homo sapiens_hsa030150.63420361
73Prolactin signaling pathway_Homo sapiens_hsa049170.63142093
74Graft-versus-host disease_Homo sapiens_hsa053320.63118366
75Insulin resistance_Homo sapiens_hsa049310.62275987
76Long-term potentiation_Homo sapiens_hsa047200.61306083
77Antigen processing and presentation_Homo sapiens_hsa046120.59320204
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57806112
79Tuberculosis_Homo sapiens_hsa051520.57138508
80Inositol phosphate metabolism_Homo sapiens_hsa005620.56794647
81Shigellosis_Homo sapiens_hsa051310.55724081
82Glioma_Homo sapiens_hsa052140.55388694
83ErbB signaling pathway_Homo sapiens_hsa040120.54622370
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53748414
85Regulation of autophagy_Homo sapiens_hsa041400.53673055
86Autoimmune thyroid disease_Homo sapiens_hsa053200.53532444
87HIF-1 signaling pathway_Homo sapiens_hsa040660.51026367
88Apoptosis_Homo sapiens_hsa042100.51001244
89RNA degradation_Homo sapiens_hsa030180.49912488
90Small cell lung cancer_Homo sapiens_hsa052220.48843000
91Choline metabolism in cancer_Homo sapiens_hsa052310.48532420
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.48451708
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47067226
94MicroRNAs in cancer_Homo sapiens_hsa052060.46745251
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42915753
96Allograft rejection_Homo sapiens_hsa053300.42755710
97Toxoplasmosis_Homo sapiens_hsa051450.42402463
98One carbon pool by folate_Homo sapiens_hsa006700.41545094
99Wnt signaling pathway_Homo sapiens_hsa043100.40103392
100Glucagon signaling pathway_Homo sapiens_hsa049220.39441289

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