POM121C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of histone H3-K27 methylation (GO:0061085)5.08012571
2negative regulation of erythrocyte differentiation (GO:0045647)4.75534461
3regulation of RNA export from nucleus (GO:0046831)4.54436450
4regulation of NFAT protein import into nucleus (GO:0051532)4.37828066
5mitotic chromosome condensation (GO:0007076)4.32122446
6negative regulation of histone methylation (GO:0031061)4.06345280
7regulation of chromatin binding (GO:0035561)4.05614432
8regulation of nucleobase-containing compound transport (GO:0032239)4.00715066
9nuclear pore complex assembly (GO:0051292)3.99387092
10negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.92585623
11DNA unwinding involved in DNA replication (GO:0006268)3.91997214
12spliceosomal tri-snRNP complex assembly (GO:0000244)3.91722812
13heterochromatin organization (GO:0070828)3.77524624
143-UTR-mediated mRNA stabilization (GO:0070935)3.70908828
15glucocorticoid receptor signaling pathway (GO:0042921)3.63214335
16histone H3-K4 methylation (GO:0051568)3.59081183
17histone H3-K36 demethylation (GO:0070544)3.57792572
18intracellular estrogen receptor signaling pathway (GO:0030520)3.57752978
19RNA stabilization (GO:0043489)3.54704550
20mRNA stabilization (GO:0048255)3.54704550
21modulation by virus of host process (GO:0019054)3.53420440
22nucleosome disassembly (GO:0006337)3.42204280
23protein-DNA complex disassembly (GO:0032986)3.42204280
24regulation of mammary gland epithelial cell proliferation (GO:0033599)3.41440509
25regulation of histone H3-K4 methylation (GO:0051569)3.40218707
26positive regulation of gene expression, epigenetic (GO:0045815)3.37486489
27histone H3-K4 trimethylation (GO:0080182)3.28961378
28DNA topological change (GO:0006265)3.27032597
29regulation of translational fidelity (GO:0006450)3.22250797
30regulation of histone methylation (GO:0031060)3.12700875
31histone lysine demethylation (GO:0070076)3.12290549
32nuclear pore organization (GO:0006999)3.09968315
33apoptotic process involved in morphogenesis (GO:0060561)3.07467572
34negative regulation of mRNA processing (GO:0050686)3.06642738
35modulation by symbiont of host cellular process (GO:0044068)3.04533799
36cell-substrate adherens junction assembly (GO:0007045)3.04226312
37focal adhesion assembly (GO:0048041)3.04226312
38histone demethylation (GO:0016577)3.03952633
39corticosteroid receptor signaling pathway (GO:0031958)3.01448592
40mannose metabolic process (GO:0006013)3.01180834
41stress granule assembly (GO:0034063)2.99729634
42adherens junction assembly (GO:0034333)2.99562944
43positive regulation of histone deacetylation (GO:0031065)2.98216968
44negative regulation of mRNA metabolic process (GO:1903312)2.97764395
45planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96424018
46positive regulation by host of viral transcription (GO:0043923)2.95170887
47mitotic nuclear envelope disassembly (GO:0007077)2.93447211
48protein export from nucleus (GO:0006611)2.92521427
49cellular response to epidermal growth factor stimulus (GO:0071364)2.91877000
50mitotic sister chromatid cohesion (GO:0007064)2.89253498
51positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.89245090
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.87370475
53nuclear envelope disassembly (GO:0051081)2.85269224
54membrane disassembly (GO:0030397)2.85269224
55thymic T cell selection (GO:0045061)2.85120847
56positive regulation of DNA-dependent DNA replication (GO:2000105)2.83326966
57modulation by virus of host morphology or physiology (GO:0019048)2.82516011
58histone deubiquitination (GO:0016578)2.82470057
59pre-miRNA processing (GO:0031054)2.82024143
60histone lysine methylation (GO:0034968)2.80337817
61histone H3-K9 demethylation (GO:0033169)2.79442787
62pore complex assembly (GO:0046931)2.77017385
63regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.75572504
64response to epidermal growth factor (GO:0070849)2.74807728
65protein demethylation (GO:0006482)2.74794551
66protein dealkylation (GO:0008214)2.74794551
67nuclear envelope organization (GO:0006998)2.74125056
68trophectodermal cell differentiation (GO:0001829)2.72895200
69dosage compensation (GO:0007549)2.72168215
70mitotic sister chromatid segregation (GO:0000070)2.71941104
71negative regulation of RNA splicing (GO:0033119)2.71767850
72positive regulation of CREB transcription factor activity (GO:0032793)2.71356882
73activation of Rac GTPase activity (GO:0032863)2.66442387
74DNA duplex unwinding (GO:0032508)2.66234973
75chromosome condensation (GO:0030261)2.64014571
76protein localization to chromosome, centromeric region (GO:0071459)2.63703639
77histone H4 deacetylation (GO:0070933)2.63424851
78negative regulation of histone modification (GO:0031057)2.62760061
79negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.61490509
80histone methylation (GO:0016571)2.61273130
81sister chromatid segregation (GO:0000819)2.60517287
82G1 DNA damage checkpoint (GO:0044783)2.57764448
83response to muramyl dipeptide (GO:0032495)2.57051605
84histone H4-K16 acetylation (GO:0043984)2.56257718
85histone H3-K9 modification (GO:0061647)2.56149644
86histone H3 acetylation (GO:0043966)2.54814656
87snRNA metabolic process (GO:0016073)2.53273750
88histone phosphorylation (GO:0016572)2.52053416
89negative regulation of viral release from host cell (GO:1902187)2.51976374
90protein localization to microtubule (GO:0035372)2.51209250
91negative regulation of cell size (GO:0045792)2.50834427
92ribosomal small subunit biogenesis (GO:0042274)2.49177202
93DNA replication initiation (GO:0006270)2.48797210
94DNA replication checkpoint (GO:0000076)2.48295816
95positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.48097848
96Peyers patch development (GO:0048541)2.47626050
97mucosal-associated lymphoid tissue development (GO:0048537)2.47626050
98COPI coating of Golgi vesicle (GO:0048205)2.47181012
99Golgi transport vesicle coating (GO:0048200)2.47181012
100regulation of mRNA stability (GO:0043488)2.46884649

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.39782131
2MYC_22102868_ChIP-Seq_BL_Human4.05627914
3VDR_21846776_ChIP-Seq_THP-1_Human3.28162550
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.03116557
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.84210204
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.60955914
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.54677218
8TCF7_22412390_ChIP-Seq_EML_Mouse2.41815211
9TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38349259
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.31730483
11KDM2B_26808549_Chip-Seq_DND41_Human2.25921974
12LXR_22292898_ChIP-Seq_THP-1_Human2.23404178
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.18955792
14KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.09574285
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03689698
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98884883
17CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.95800471
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94871192
19RACK7_27058665_Chip-Seq_MCF-7_Human1.91487212
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88880084
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.83356378
22MAF_26560356_Chip-Seq_TH1_Human1.82300749
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79999926
24XRN2_22483619_ChIP-Seq_HELA_Human1.72740157
25MAF_26560356_Chip-Seq_TH2_Human1.70363663
26KDM2B_26808549_Chip-Seq_K562_Human1.68472711
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67992129
28KDM2B_26808549_Chip-Seq_JURKAT_Human1.67763860
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.67154856
30VDR_24763502_ChIP-Seq_THP-1_Human1.66644663
31CIITA_25753668_ChIP-Seq_RAJI_Human1.66203847
32CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.64900014
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.63435866
34UTX_26944678_Chip-Seq_JUKART_Human1.60481754
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59378055
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58756988
37CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.58057408
38NCOR1_26117541_ChIP-Seq_K562_Human1.53005029
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.47807993
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47639033
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47443234
42P68_20966046_ChIP-Seq_HELA_Human1.47390133
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38281496
44EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37637400
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36336954
46CREB1_26743006_Chip-Seq_LNCaP_Human1.34739171
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34371336
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33510634
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31965405
50ZNF263_19887448_ChIP-Seq_K562_Human1.29273444
51PKCTHETA_26484144_Chip-Seq_BREAST_Human1.26423620
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.26352430
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.25236537
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24951634
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24331373
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23611131
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21962261
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.21688460
59* SMC4_20622854_ChIP-Seq_HELA_Human1.21632379
60KDM5A_27292631_Chip-Seq_BREAST_Human1.20047690
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19306621
62CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18540986
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18086021
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17170799
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16706749
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16365312
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16251751
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14833607
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14724195
70MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13747910
71ATF3_27146783_Chip-Seq_COLON_Human1.13693166
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13321817
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12627224
74RUNX1_27514584_Chip-Seq_MCF-7_Human1.12206076
75TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11929591
76SCL_19346495_ChIP-Seq_HPC-7_Human1.11214392
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.09661093
78SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09352432
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09306698
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09055214
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.07549694
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07253030
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03680198
84TP53_22127205_ChIP-Seq_IMR90_Human1.03148962
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02507814
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00614082
87CHD1_26751641_Chip-Seq_LNCaP_Human0.99556979
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98885850
89MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98837615
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98617087
91ELF1_20517297_ChIP-Seq_JURKAT_Human0.97881899
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96494134
93NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95145532
94HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94978207
95THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94544573
96MYB_26560356_Chip-Seq_TH1_Human0.94076577
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93510325
98SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93261792
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91146556
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90726141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005076_abnormal_cell_differentiation3.89651378
2MP0003705_abnormal_hypodermis_morpholog3.86493411
3MP0003111_abnormal_nucleus_morphology2.94903272
4MP0009278_abnormal_bone_marrow2.89489562
5MP0005409_darkened_coat_color2.72517326
6MP0002396_abnormal_hematopoietic_system2.58551330
7MP0008057_abnormal_DNA_replication2.58374799
8MP0005451_abnormal_body_composition2.45896160
9MP0002249_abnormal_larynx_morphology2.27437312
10MP0004381_abnormal_hair_follicle2.16375824
11MP0004808_abnormal_hematopoietic_stem2.12438403
12MP0003077_abnormal_cell_cycle2.07935519
13MP0000678_abnormal_parathyroid_gland2.07241214
14MP0003763_abnormal_thymus_physiology2.06291715
15MP0010094_abnormal_chromosome_stability2.05916064
16MP0001730_embryonic_growth_arrest2.03861318
17MP0003693_abnormal_embryo_hatching1.97361692
18MP0000350_abnormal_cell_proliferation1.86141521
19MP0003123_paternal_imprinting1.84828039
20MP0004233_abnormal_muscle_weight1.84025965
21MP0000703_abnormal_thymus_morphology1.77445483
22MP0002877_abnormal_melanocyte_morpholog1.70451145
23MP0004957_abnormal_blastocyst_morpholog1.65618513
24MP0003984_embryonic_growth_retardation1.64227675
25MP0005380_embryogenesis_phenotype1.62594740
26MP0001672_abnormal_embryogenesis/_devel1.62594740
27MP0004264_abnormal_extraembryonic_tissu1.62546375
28MP0002009_preneoplasia1.60200282
29MP0009672_abnormal_birth_weight1.55393742
30MP0001849_ear_inflammation1.54479302
31MP0004185_abnormal_adipocyte_glucose1.53976162
32MP0002088_abnormal_embryonic_growth/wei1.53971241
33MP0001873_stomach_inflammation1.49310698
34MP0001348_abnormal_lacrimal_gland1.46853090
35MP0004858_abnormal_nervous_system1.40289263
36MP0003453_abnormal_keratinocyte_physiol1.38779517
37MP0003091_abnormal_cell_migration1.38424105
38MP0009333_abnormal_splenocyte_physiolog1.38384749
39MP0002080_prenatal_lethality1.38377227
40MP0002086_abnormal_extraembryonic_tissu1.37059291
41MP0003300_gastrointestinal_ulcer1.35726126
42MP0001697_abnormal_embryo_size1.34607293
43MP0004197_abnormal_fetal_growth/weight/1.33316846
44MP0002398_abnormal_bone_marrow1.30057842
45MP0002089_abnormal_postnatal_growth/wei1.28984734
46MP0008932_abnormal_embryonic_tissue1.27920328
47MP0002796_impaired_skin_barrier1.27843999
48MP0003172_abnormal_lysosome_physiology1.27468104
49MP0005501_abnormal_skin_physiology1.26105897
50MP0005621_abnormal_cell_physiology1.24857912
51MP0008961_abnormal_basal_metabolism1.23040555
52MP0005666_abnormal_adipose_tissue1.20880126
53MP0002085_abnormal_embryonic_tissue1.17670662
54MP0003115_abnormal_respiratory_system1.17604116
55MP0004947_skin_inflammation1.17364662
56MP0008260_abnormal_autophagy1.15962008
57MP0000313_abnormal_cell_death1.12798302
58MP0003566_abnormal_cell_adhesion1.10309812
59MP0000733_abnormal_muscle_development1.08358141
60MP0003436_decreased_susceptibility_to1.07725639
61MP0005058_abnormal_lysosome_morphology1.05493128
62MP0001346_abnormal_lacrimal_gland1.05011341
63MP0009931_abnormal_skin_appearance1.04936345
64MP0002722_abnormal_immune_system1.03944980
65MP0005375_adipose_tissue_phenotype1.03791221
66MP0005171_absent_coat_pigmentation1.02644599
67MP0000003_abnormal_adipose_tissue1.01731740
68MP0010630_abnormal_cardiac_muscle1.01382893
69MP0003942_abnormal_urinary_system0.99497920
70MP0010307_abnormal_tumor_latency0.99203246
71MP0002019_abnormal_tumor_incidence0.98693661
72MP0002970_abnormal_white_adipose0.98092139
73MP0002084_abnormal_developmental_patter0.94756395
74MP0005384_cellular_phenotype0.89250490
75MP0002429_abnormal_blood_cell0.89227145
76MP0005397_hematopoietic_system_phenotyp0.88538698
77MP0001545_abnormal_hematopoietic_system0.88538698
78MP0005423_abnormal_somatic_nervous0.87584566
79MP0003943_abnormal_hepatobiliary_system0.87569576
80MP0002925_abnormal_cardiovascular_devel0.86998449
81MP0002098_abnormal_vibrissa_morphology0.83340963
82MP0008007_abnormal_cellular_replicative0.82989110
83MP0001915_intracranial_hemorrhage0.81612894
84MP0000490_abnormal_crypts_of0.81463562
85MP0000858_altered_metastatic_potential0.81247283
86MP0000716_abnormal_immune_system0.80483363
87MP0009703_decreased_birth_body0.79148323
88MP0000428_abnormal_craniofacial_morphol0.77763674
89MP0001853_heart_inflammation0.75648041
90MP0009115_abnormal_fat_cell0.73852815
91MP0000685_abnormal_immune_system0.73783958
92MP0000689_abnormal_spleen_morphology0.73572793
93MP0010030_abnormal_orbit_morphology0.73131371
94MP0002060_abnormal_skin_morphology0.72659062
95MP0002116_abnormal_craniofacial_bone0.72143768
96MP0001502_abnormal_circadian_rhythm0.71914805
97MP0003303_peritoneal_inflammation0.71807527
98MP0001216_abnormal_epidermal_layer0.71702199
99MP0003935_abnormal_craniofacial_develop0.71459150
100MP0000566_synostosis0.70639162

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)4.58191880
2Abnormality of the fingertips (HP:0001211)4.11159777
3Obstructive sleep apnea (HP:0002870)3.84710956
4Broad face (HP:0000283)3.18493089
5Ulnar bowing (HP:0003031)3.03111370
6Long eyelashes (HP:0000527)2.94420731
7Insomnia (HP:0100785)2.90490516
8Disproportionate tall stature (HP:0001519)2.85141110
9Long palpebral fissure (HP:0000637)2.78840234
10Urethral obstruction (HP:0000796)2.66939596
11Patellar dislocation (HP:0002999)2.56667009
12Abnormality of the columella (HP:0009929)2.49065413
13Abnormality of the distal phalanx of the thumb (HP:0009617)2.47938438
14Sparse lateral eyebrow (HP:0005338)2.41352511
15Elfin facies (HP:0004428)2.41112696
16Dysmetric saccades (HP:0000641)2.40671936
17Overriding aorta (HP:0002623)2.35887188
18Dislocated radial head (HP:0003083)2.34757740
19Abnormality of the phalanges of the hallux (HP:0010057)2.33877988
20Septate vagina (HP:0001153)2.31124932
21Increased nuchal translucency (HP:0010880)2.29633001
22Renal duplication (HP:0000075)2.27258114
23Pointed chin (HP:0000307)2.27112324
24Renovascular hypertension (HP:0100817)2.23867256
25Truncus arteriosus (HP:0001660)2.23590012
26Abnormality of the radial head (HP:0003995)2.22843904
27Thin bony cortex (HP:0002753)2.22007298
28Deep palmar crease (HP:0006191)2.21395595
29Bowel incontinence (HP:0002607)2.19356074
30Obsessive-compulsive behavior (HP:0000722)2.18326359
31Intestinal fistula (HP:0100819)2.16496811
32Annular pancreas (HP:0001734)2.16361148
33Shallow orbits (HP:0000586)2.15779861
34Birth length less than 3rd percentile (HP:0003561)2.15002312
35Abnormality of the aortic arch (HP:0012303)2.10807649
36Flat cornea (HP:0007720)2.09478157
37Heterotopia (HP:0002282)2.09315793
38Premature skin wrinkling (HP:0100678)2.09158200
39Trigonocephaly (HP:0000243)2.08818845
40Thin ribs (HP:0000883)2.08781911
41Facial hemangioma (HP:0000329)2.08386345
42Supernumerary ribs (HP:0005815)2.06234166
43Poikiloderma (HP:0001029)2.05344940
44Spina bifida occulta (HP:0003298)2.03544677
45Asymmetry of the thorax (HP:0001555)2.00334222
46Abnormal large intestine physiology (HP:0012700)1.99826999
47Progressive muscle weakness (HP:0003323)1.98758027
48Seborrheic dermatitis (HP:0001051)1.96498880
49Abnormality of the parietal bone (HP:0002696)1.95861363
50Abnormality of the thoracic spine (HP:0100711)1.95800310
51Overlapping toe (HP:0001845)1.93926702
52Turricephaly (HP:0000262)1.92807160
53Broad palm (HP:0001169)1.90788694
54High anterior hairline (HP:0009890)1.90517259
55Hemorrhage of the eye (HP:0011885)1.88585212
56Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86675369
57Lip pit (HP:0100267)1.86426024
58Self-mutilation (HP:0000742)1.86403608
59Ankyloglossia (HP:0010296)1.85540977
60Flat acetabular roof (HP:0003180)1.83410956
61Breast hypoplasia (HP:0003187)1.82481994
62Precocious puberty (HP:0000826)1.80037089
63Distal upper limb amyotrophy (HP:0007149)1.77281815
64Upper limb amyotrophy (HP:0009129)1.77281815
65Arnold-Chiari malformation (HP:0002308)1.77204607
66Deviation of the thumb (HP:0009603)1.76583528
67Reticulocytosis (HP:0001923)1.75188472
68Macroorchidism (HP:0000053)1.74806585
69Supernumerary bones of the axial skeleton (HP:0009144)1.74061533
70Cerebral aneurysm (HP:0004944)1.73513629
71Narrow palate (HP:0000189)1.73157407
72Germ cell neoplasia (HP:0100728)1.73120992
73Fatigue (HP:0012378)1.72769392
74Acute lymphatic leukemia (HP:0006721)1.72197459
75Slow saccadic eye movements (HP:0000514)1.72045538
76Capillary hemangiomas (HP:0005306)1.68889442
77Distal lower limb amyotrophy (HP:0008944)1.68695800
78Proximal placement of thumb (HP:0009623)1.68257638
79Cholecystitis (HP:0001082)1.68023422
80Abnormal gallbladder physiology (HP:0012438)1.68023422
81Cellulitis (HP:0100658)1.67507622
82Basal cell carcinoma (HP:0002671)1.67197379
83Hypertensive crisis (HP:0100735)1.65663542
84Hyperthyroidism (HP:0000836)1.63917711
85Broad distal phalanx of finger (HP:0009836)1.63630084
86Deep philtrum (HP:0002002)1.63079412
87Abnormality of oral frenula (HP:0000190)1.63040280
88Broad thumb (HP:0011304)1.62527034
89Centrally nucleated skeletal muscle fibers (HP:0003687)1.62022389
90Abnormality of the humeroradial joint (HP:0100744)1.61908840
91Pseudobulbar signs (HP:0002200)1.61886273
92Protrusio acetabuli (HP:0003179)1.61842992
93Preauricular skin tag (HP:0000384)1.60111515
94Mitral regurgitation (HP:0001653)1.59184850
95Segmental peripheral demyelination/remyelination (HP:0003481)1.58875752
96Syringomyelia (HP:0003396)1.58784718
97Spinal cord lesions (HP:0100561)1.58784718
98Neonatal hypoglycemia (HP:0001998)1.58069299
99Easy fatigability (HP:0003388)1.57475458
100Metaphyseal cupping (HP:0003021)1.57014710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.71622917
2TRIB34.35016980
3SMG13.57806573
4ICK3.29642264
5EEF2K3.27617410
6PRPF4B3.22484508
7SIK13.07007391
8MAP3K102.86800476
9ERN12.28137857
10SIK22.15414591
11BRD42.00593724
12FGFR41.93783719
13MTOR1.59799897
14MAP4K11.58816595
15IRAK31.48464859
16PKN21.47602701
17CAMK1D1.47054156
18SIK31.41421153
19MAP3K131.36695335
20KSR21.27327064
21CDK41.26974535
22MARK21.17055312
23CAMK1G1.13755141
24CDK71.13049916
25TYRO31.10730294
26MAP2K31.10107790
27RIPK41.01884257
28MAPK110.94497453
29CDC42BPA0.90853166
30PRKD20.89105890
31PRKD30.88791899
32RPS6KB20.88469434
33HIPK20.86160135
34MAP3K90.86132937
35TAOK20.85615287
36CDC70.85177871
37PDGFRA0.82582688
38PTK60.80916070
39RIPK10.77905456
40IRAK20.77850161
41MAP3K70.77100283
42LATS20.75114466
43EPHB10.73749717
44MAP3K140.72703831
45RET0.71929872
46WNK10.71793329
47CHEK10.71605943
48MELK0.71567838
49MAP3K80.71566707
50EPHA20.68248628
51CDK90.67416756
52MAP3K10.67379624
53PASK0.66863735
54NEK20.64366244
55FGFR30.63589010
56TAOK10.63432014
57PDPK10.63020269
58MAP2K20.61535279
59LRRK20.61521365
60CDK20.61498601
61CLK10.61390724
62RPS6KA20.59612693
63IRAK40.59117619
64BTK0.57640461
65ATR0.57180459
66CHEK20.56391184
67CDK60.55721521
68TTN0.54904692
69MAPK120.54882687
70RPS6KC10.54658105
71RPS6KL10.54658105
72CHUK0.51819212
73TNK20.49501358
74CDK10.49255817
75ZAP700.47338167
76SGK30.47242249
77PTK20.46777189
78NME20.46741376
79ALK0.44755902
80BMX0.44704222
81ARAF0.43256688
82RAF10.43052963
83PRKCH0.42144074
84PDK10.40809187
85GSK3B0.40454396
86MAPK100.40394008
87RPS6KA60.40357773
88RPS6KA10.39375741
89BRAF0.38734114
90DMPK0.38355777
91MAPK140.37791840
92MAPK80.37478566
93CDK80.37367622
94CDK30.36960411
95AKT10.36851615
96BRSK10.36356422
97STK100.36142951
98GRK60.35836220
99MAPK10.33760158
100MAPKAPK20.33630265

Predicted pathways (KEGG)

RankGene SetZ-score
1Acute myeloid leukemia_Homo sapiens_hsa052212.55466592
2Chronic myeloid leukemia_Homo sapiens_hsa052202.50319554
3Non-small cell lung cancer_Homo sapiens_hsa052232.31221326
4Notch signaling pathway_Homo sapiens_hsa043302.14774524
5Thyroid cancer_Homo sapiens_hsa052161.96222846
6Endometrial cancer_Homo sapiens_hsa052131.90617102
7B cell receptor signaling pathway_Homo sapiens_hsa046621.87286085
8Pancreatic cancer_Homo sapiens_hsa052121.82504576
9mRNA surveillance pathway_Homo sapiens_hsa030151.76732667
10Renal cell carcinoma_Homo sapiens_hsa052111.75398159
11Lysine degradation_Homo sapiens_hsa003101.74363564
12VEGF signaling pathway_Homo sapiens_hsa043701.69726448
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.67650041
14Colorectal cancer_Homo sapiens_hsa052101.64767912
15Prostate cancer_Homo sapiens_hsa052151.62522667
16mTOR signaling pathway_Homo sapiens_hsa041501.58579354
17DNA replication_Homo sapiens_hsa030301.58030316
18Thyroid hormone signaling pathway_Homo sapiens_hsa049191.57368802
19Central carbon metabolism in cancer_Homo sapiens_hsa052301.54168720
20Cell cycle_Homo sapiens_hsa041101.51714515
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51343074
22MicroRNAs in cancer_Homo sapiens_hsa052061.50612426
23Bladder cancer_Homo sapiens_hsa052191.49985214
24ErbB signaling pathway_Homo sapiens_hsa040121.49890847
25Spliceosome_Homo sapiens_hsa030401.48030813
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.47399261
27Hepatitis B_Homo sapiens_hsa051611.42536362
28T cell receptor signaling pathway_Homo sapiens_hsa046601.34083590
29Glioma_Homo sapiens_hsa052141.32000330
30Base excision repair_Homo sapiens_hsa034101.25577636
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22381753
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20233926
33Longevity regulating pathway - mammal_Homo sapiens_hsa042111.17883601
34Prolactin signaling pathway_Homo sapiens_hsa049171.16139545
35HTLV-I infection_Homo sapiens_hsa051661.15615289
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15188668
37Inositol phosphate metabolism_Homo sapiens_hsa005621.14002640
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13180322
39Insulin signaling pathway_Homo sapiens_hsa049101.12232899
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11520915
41Fructose and mannose metabolism_Homo sapiens_hsa000511.09402918
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08096266
43Choline metabolism in cancer_Homo sapiens_hsa052311.06555292
44Small cell lung cancer_Homo sapiens_hsa052221.05920103
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03998575
46Adherens junction_Homo sapiens_hsa045201.03082082
47Measles_Homo sapiens_hsa051621.02518430
48Epstein-Barr virus infection_Homo sapiens_hsa051690.99687545
49Apoptosis_Homo sapiens_hsa042100.98680163
50FoxO signaling pathway_Homo sapiens_hsa040680.95554464
51* RNA transport_Homo sapiens_hsa030130.95461157
52Herpes simplex infection_Homo sapiens_hsa051680.94956223
53Influenza A_Homo sapiens_hsa051640.94219969
54Estrogen signaling pathway_Homo sapiens_hsa049150.93341873
55Other glycan degradation_Homo sapiens_hsa005110.91725868
56Viral carcinogenesis_Homo sapiens_hsa052030.90914863
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90490688
58Hepatitis C_Homo sapiens_hsa051600.90441010
59AMPK signaling pathway_Homo sapiens_hsa041520.88320374
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.87720239
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.85506630
62Prion diseases_Homo sapiens_hsa050200.83721160
63HIF-1 signaling pathway_Homo sapiens_hsa040660.83639080
64Insulin resistance_Homo sapiens_hsa049310.82010065
65Type II diabetes mellitus_Homo sapiens_hsa049300.78934918
66Osteoclast differentiation_Homo sapiens_hsa043800.78358152
67Basal cell carcinoma_Homo sapiens_hsa052170.77222087
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76854105
69TNF signaling pathway_Homo sapiens_hsa046680.74820455
70Proteoglycans in cancer_Homo sapiens_hsa052050.72599902
71Long-term potentiation_Homo sapiens_hsa047200.72529895
72GnRH signaling pathway_Homo sapiens_hsa049120.72478713
73MAPK signaling pathway_Homo sapiens_hsa040100.69978254
74Wnt signaling pathway_Homo sapiens_hsa043100.69707596
75Primary immunodeficiency_Homo sapiens_hsa053400.68272899
76Melanogenesis_Homo sapiens_hsa049160.67636184
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65310729
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.63772912
79Pathways in cancer_Homo sapiens_hsa052000.62215831
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61063692
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59671890
82Pentose phosphate pathway_Homo sapiens_hsa000300.59052407
83Toxoplasmosis_Homo sapiens_hsa051450.57941554
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56492821
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56335075
86Sulfur relay system_Homo sapiens_hsa041220.55862330
87Melanoma_Homo sapiens_hsa052180.55622638
88One carbon pool by folate_Homo sapiens_hsa006700.55209002
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55179574
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.54122165
91Focal adhesion_Homo sapiens_hsa045100.53642629
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53490613
93Dorso-ventral axis formation_Homo sapiens_hsa043200.52393550
94Biosynthesis of amino acids_Homo sapiens_hsa012300.50608789
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50582001
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.50258441
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48799926
98Hippo signaling pathway_Homo sapiens_hsa043900.47452875
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.47416499
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46402777

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