ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cell-cell recognition (GO:0009988)	9.95740353
2	spermatid development (GO:0007286)	9.75247926
3	motile cilium assembly (GO:0044458)	9.66682107
4	piRNA metabolic process (GO:0034587)	9.57446690
5	plasma membrane fusion (GO:0045026)	9.51593005
6	reproduction (GO:0000003)	8.86447778
7	regulation of cilium movement (GO:0003352)	8.75232090
8	cilium movement (GO:0003341)	8.57691066
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	8.18476678
10	male meiosis (GO:0007140)	8.05122042
11	synaptonemal complex organization (GO:0070193)	7.83092789
12	synaptonemal complex assembly (GO:0007130)	7.56858408
13	single fertilization (GO:0007338)	7.25493329
14	sperm capacitation (GO:0048240)	7.25450531
15	negative regulation of inclusion body assembly (GO:0090084)	6.86560133
16	spermatogenesis (GO:0007283)	6.45967118
17	male gamete generation (GO:0048232)	6.43580757
18	fertilization (GO:0009566)	6.29357362
19	organic cation transport (GO:0015695)	5.94306766
20	microtubule depolymerization (GO:0007019)	5.91837604
21	gamete generation (GO:0007276)	5.91325460
22	DNA methylation involved in gamete generation (GO:0043046)	5.85045217
23	male meiosis I (GO:0007141)	5.70000276
24	regulation of inclusion body assembly (GO:0090083)	5.62759000
25	germ cell development (GO:0007281)	5.57231103
26	cellular process involved in reproduction in multicellular organism (GO:0022412)	5.40900032
27	ventricular system development (GO:0021591)	5.38434976
28	chromosome organization involved in meiosis (GO:0070192)	5.25754992
29	regulation of microtubule-based movement (GO:0060632)	5.18199605
30	calcium ion-dependent exocytosis (GO:0017156)	5.16856449
31	seminiferous tubule development (GO:0072520)	4.99054376
32	meiotic nuclear division (GO:0007126)	4.85166808
33	cell recognition (GO:0008037)	4.78544726
34	left/right pattern formation (GO:0060972)	4.71141170
35	microtubule severing (GO:0051013)	4.70487525
36	multicellular organismal reproductive process (GO:0048609)	4.65290138
37	meiosis I (GO:0007127)	4.57705500
38	meiotic cell cycle (GO:0051321)	4.39490670
39	chromosome condensation (GO:0030261)	4.33890720
40	spermatid nucleus differentiation (GO:0007289)	4.31604435
41	DNA packaging (GO:0006323)	4.23653473
42	glycerol ether metabolic process (GO:0006662)	4.08645595
43	chaperone-mediated protein complex assembly (GO:0051131)	3.88548274
44	protein localization to cilium (GO:0061512)	3.88388190
45	genitalia morphogenesis (GO:0035112)	3.87532790
46	protein polyglutamylation (GO:0018095)	3.85411145
47	ether metabolic process (GO:0018904)	3.77333678
48	multicellular organismal development (GO:0007275)	3.74348786
49	gene silencing by RNA (GO:0031047)	3.63507292
50	monoubiquitinated protein deubiquitination (GO:0035520)	3.61434998
51	single strand break repair (GO:0000012)	3.37359008
52	sexual reproduction (GO:0019953)	3.37336107
53	regulation of spindle checkpoint (GO:0090231)	3.35836034
54	amino-acid betaine transport (GO:0015838)	3.31633472
55	carnitine transport (GO:0015879)	3.31633472
56	protein refolding (GO:0042026)	3.30338954
57	intraciliary transport (GO:0042073)	3.27554806
58	carnitine transmembrane transport (GO:1902603)	3.23707384
59	axoneme assembly (GO:0035082)	3.20937872
60	microtubule-based movement (GO:0007018)	3.20157888
61	meiotic cell cycle process (GO:1903046)	3.18337460
62	negative regulation of organelle assembly (GO:1902116)	3.16874206
63	nucleus organization (GO:0006997)	3.06588658
64	synapsis (GO:0007129)	3.05726221
65	mitotic sister chromatid cohesion (GO:0007064)	3.05059728
66	microtubule polymerization or depolymerization (GO:0031109)	3.01580079
67	cilium organization (GO:0044782)	3.00862383
68	alditol metabolic process (GO:0019400)	2.97976851
69	polyol catabolic process (GO:0046174)	2.96377664
70	interferon-gamma secretion (GO:0072643)	2.95373482
71	glycolytic process (GO:0006096)	2.91347587
72	nucleoside diphosphate phosphorylation (GO:0006165)	2.91034394
73	gene silencing (GO:0016458)	2.87670087
74	protein K11-linked deubiquitination (GO:0035871)	2.87168340
75	cilium assembly (GO:0042384)	2.85929142
76	peptidyl-glutamic acid modification (GO:0018200)	2.81867073
77	regulation of meiosis I (GO:0060631)	2.80463392
78	RNA localization (GO:0006403)	2.77185763
79	lactate metabolic process (GO:0006089)	2.76412415
80	cellular component assembly involved in morphogenesis (GO:0010927)	2.75154870
81	regulation of centriole replication (GO:0046599)	2.74704788
82	cilium morphogenesis (GO:0060271)	2.73936094
83	nuclear pore complex assembly (GO:0051292)	2.72550662
84	sequestering of actin monomers (GO:0042989)	2.63023936
85	centriole assembly (GO:0098534)	2.57109706
86	sex differentiation (GO:0007548)	2.56600183
87	glycerol metabolic process (GO:0006071)	2.55419580
88	regulation of cilium assembly (GO:1902017)	2.52577306
89	sperm motility (GO:0030317)	13.4286480
90	cilium or flagellum-dependent cell motility (GO:0001539)	12.8383114
91	fusion of sperm to egg plasma membrane (GO:0007342)	12.4975085
92	acrosome reaction (GO:0007340)	11.6356159
93	sperm-egg recognition (GO:0035036)	11.1328732
94	axonemal dynein complex assembly (GO:0070286)	10.7702473
95	acrosome assembly (GO:0001675)	10.5336190
96	multicellular organism reproduction (GO:0032504)	10.4333682
97	cell wall macromolecule metabolic process (GO:0044036)	10.4320311
98	cell wall macromolecule catabolic process (GO:0016998)	10.4320311
99	binding of sperm to zona pellucida (GO:0007339)	10.2911594
100	epithelial cilium movement (GO:0003351)	10.1704065

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.18382251
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.08845085
3	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.96142223
4	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.63664942
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.62656545
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.59529005
7	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	2.37712834
8	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.30810178
9	VDR_22108803_ChIP-Seq_LS180_Human	2.29890612
10	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.18332241
11	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	2.02551990
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	11.0882526
13	ZNF274_21170338_ChIP-Seq_K562_Hela	1.93591006
14	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.90084434
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.89923231
16	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.80971091
17	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.66031281
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62743539
19	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.58995935
20	* STAT1_17558387_ChIP-Seq_HELA_Human	1.58066502
21	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.56494417
22	* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.52986056
23	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.49823732
24	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.41097224
25	* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.40238356
26	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.39304383
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38823756
28	* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.38515101
29	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.35279978
30	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.32766586
31	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.32356535
32	REST_21632747_ChIP-Seq_MESCs_Mouse	1.31754187
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.30703109
34	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.27850550
35	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27456817
36	* CBP_20019798_ChIP-Seq_JUKART_Human	1.27456817
37	* KDM2B_26808549_Chip-Seq_REH_Human	1.24923889
38	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24500364
39	P53_21459846_ChIP-Seq_SAOS-2_Human	1.24443170
40	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.22283130
41	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.20405459
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.18546794
43	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.17945127
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.17826333
45	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17826333
46	* LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.17084338
47	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.15959810
48	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.15871015
49	GF1_26923725_Chip-Seq_HPCs_Mouse	1.13247848
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.09205795
51	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.08866955
52	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.08763128
53	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08308862
54	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07353489
55	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07083219
56	* FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05520729
57	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.03670964
58	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.03446128
59	SPI1_26923725_Chip-Seq_HPCs_Mouse	1.02323372
60	* RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.01884533
61	MYC_27129775_Chip-Seq_CORNEA_Mouse	1.01658439
62	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01656669
63	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.01420246
64	ERG_20517297_ChIP-Seq_VCAP_Human	1.00931336
65	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.00464970
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00148617
67	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	1.00077295
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99275452
69	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.98443298
70	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.97714874
71	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95350865
72	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.95239659
73	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.94897507
74	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.94179609
75	CTCF_20526341_ChIP-Seq_ESCs_Human	0.93307683
76	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.91985806
77	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.91973139
78	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.91833657
79	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.91425208
80	SOX2_21211035_ChIP-Seq_LN229_Human	0.91255136
81	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.90258646
82	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.89634565
83	SOX11_22085726_ChIP-Seq_ESNs_Mouse	0.89095171
84	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.88594796
85	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.88579538
86	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.88399211
87	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.88002673
88	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.87819767
89	NFYB_21822215_ChIP-Seq_K562_Human	0.87323420
90	NANOG_20526341_ChIP-Seq_ESCs_Human	0.87219750
91	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.87109767
92	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.86725086
93	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.86134198
94	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.85607932
95	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.85158301
96	RNF2_27304074_Chip-Seq_NSC_Mouse	0.84314182
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.83161342
98	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.83065978
99	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.82812819
100	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.82617002

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	6.07186144
2	MP0001929_abnormal_gametogenesis	5.54902898
3	MP0008877_abnormal_DNA_methylation	4.61811893
4	MP0002210_abnormal_sex_determination	3.64864020
5	MP0002161_abnormal_fertility/fecundity	3.32408874
6	MP0001145_abnormal_male_reproductive	3.06440401
7	MP0002653_abnormal_ependyma_morphology	3.06162043
8	MP0000653_abnormal_sex_gland	2.65377431
9	MP0005670_abnormal_white_adipose	2.25103497
10	MP0005410_abnormal_fertilization	15.9906962
11	MP0005623_abnormal_meninges_morphology	1.89932019
12	MP0002160_abnormal_reproductive_system	1.80182873
13	MP0003646_muscle_fatigue	1.65354301
14	MP0002282_abnormal_trachea_morphology	1.43273432
15	MP0004233_abnormal_muscle_weight	1.22076956
16	MP0008995_early_reproductive_senescence	1.07702176
17	MP0008058_abnormal_DNA_repair	1.01878872
18	MP0001765_abnormal_ion_homeostasis	0.98406025
19	MP0001984_abnormal_olfaction	0.96950359
20	MP0000569_abnormal_digit_pigmentation	0.96300960
21	MP0005647_abnormal_sex_gland	0.95335123
22	MP0009046_muscle_twitch	0.91612726
23	MP0005389_reproductive_system_phenotype	0.85768142
24	MP0003329_amyloid_beta_deposits	0.80846972
25	MP0003115_abnormal_respiratory_system	0.79326211
26	MP0010094_abnormal_chromosome_stability	0.78564811
27	MP0003011_delayed_dark_adaptation	0.77478373
28	MP0005377_hearing/vestibular/ear_phenot	0.72775760
29	MP0003878_abnormal_ear_physiology	0.72775760
30	MP0000358_abnormal_cell_content/	0.66824003
31	MP0002234_abnormal_pharynx_morphology	0.60706167
32	MP0003111_abnormal_nucleus_morphology	0.57472419
33	MP0008057_abnormal_DNA_replication	0.57129143
34	MP0005636_abnormal_mineral_homeostasis	0.55121366
35	MP0009278_abnormal_bone_marrow	0.54351048
36	MP0008007_abnormal_cellular_replicative	0.52587085
37	MP0003786_premature_aging	0.51048867
38	MP0005397_hematopoietic_system_phenotyp	0.50269557
39	MP0001545_abnormal_hematopoietic_system	0.50269557
40	MP0003699_abnormal_female_reproductive	0.49924068
41	MP0001293_anophthalmia	0.49227203
42	MP0005666_abnormal_adipose_tissue	0.44832060
43	MP0001324_abnormal_eye_pigmentation	0.43944226
44	MP0004808_abnormal_hematopoietic_stem	0.42426729
45	MP0004036_abnormal_muscle_relaxation	0.42169866
46	MP0000604_amyloidosis	0.41721477
47	MP0003950_abnormal_plasma_membrane	0.41268828
48	MP0002928_abnormal_bile_duct	0.39019948
49	MP0002269_muscular_atrophy	0.38010730
50	MP0001764_abnormal_homeostasis	0.37913538
51	MP0001730_embryonic_growth_arrest	0.37663528
52	MP0001119_abnormal_female_reproductive	0.37204044
53	MP0005253_abnormal_eye_physiology	0.33031229
54	MP0005391_vision/eye_phenotype	0.32853274
55	MP0000534_abnormal_ureter_morphology	0.31860435
56	MP0005551_abnormal_eye_electrophysiolog	0.31834036
57	MP0003942_abnormal_urinary_system	0.31355916
58	MP0002971_abnormal_brown_adipose	0.30739954
59	MP0004811_abnormal_neuron_physiology	0.30729624
60	MP0009115_abnormal_fat_cell	0.29285168
61	MP0003861_abnormal_nervous_system	0.29283842
62	MP0001727_abnormal_embryo_implantation	0.28849353
63	MP0000313_abnormal_cell_death	0.27841494
64	MP0006036_abnormal_mitochondrial_physio	0.27408988
65	MP0002152_abnormal_brain_morphology	0.27319638
66	MP0002736_abnormal_nociception_after	0.26305663
67	MP0000015_abnormal_ear_pigmentation	0.26280612
68	MP0008961_abnormal_basal_metabolism	0.26070624
69	MP0010307_abnormal_tumor_latency	0.25213326
70	MP0004133_heterotaxia	0.25045869
71	MP0002092_abnormal_eye_morphology	0.24959366
72	MP0006035_abnormal_mitochondrial_morpho	0.24244761
73	MP0003879_abnormal_hair_cell	0.24078190
74	MP0004019_abnormal_vitamin_homeostasis	0.22322541
75	MP0003631_nervous_system_phenotype	0.21555021
76	MP0002084_abnormal_developmental_patter	0.20403140
77	MP0003948_abnormal_gas_homeostasis	0.20388363
78	MP0003077_abnormal_cell_cycle	0.19934041
79	MP0002102_abnormal_ear_morphology	0.19473139
80	MP0003045_fibrosis	0.19458330
81	MP0005423_abnormal_somatic_nervous	0.19252910
82	MP0002169_no_abnormal_phenotype	0.18951727
83	MP0002873_normal_phenotype	0.18693130
84	MP0001661_extended_life_span	0.18484332
85	MP0001672_abnormal_embryogenesis/_devel	0.17848663
86	MP0005380_embryogenesis_phenotype	0.17848663
87	MP0001986_abnormal_taste_sensitivity	0.17737737
88	MP0002295_abnormal_pulmonary_circulatio	0.17692109
89	MP0003936_abnormal_reproductive_system	0.17076024
90	MP0009672_abnormal_birth_weight	0.16819571
91	MP0003632_abnormal_nervous_system	0.16269405
92	MP0005174_abnormal_tail_pigmentation	0.15987347
93	MP0003633_abnormal_nervous_system	0.15963937
94	MP0000751_myopathy	0.15941551
95	MP0001697_abnormal_embryo_size	0.15861586
96	MP0002405_respiratory_system_inflammati	0.14889602
97	MP0002229_neurodegeneration	0.14617832
98	MP0004043_abnormal_pH_regulation	0.14588761
99	MP0000001_mammalian_phenotype	0.14238943
100	MP0004742_abnormal_vestibular_system	0.13439861

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory motile cilium morphology (HP:0005938)	9.21455162
2	Abnormal respiratory epithelium morphology (HP:0012253)	9.21455162
3	Abnormal respiratory motile cilium physiology (HP:0012261)	9.19626827
4	Rhinitis (HP:0012384)	7.79041595
5	Abnormal ciliary motility (HP:0012262)	7.20846076
6	Chronic bronchitis (HP:0004469)	7.09740898
7	Infertility (HP:0000789)	6.87009918
8	Nasal polyposis (HP:0100582)	6.50723391
9	Abnormality of the nasal mucosa (HP:0000433)	5.40911618
10	Bronchitis (HP:0012387)	4.63595921
11	Bronchiectasis (HP:0002110)	4.61399493
12	Nephronophthisis (HP:0000090)	4.52196165
13	Male infertility (HP:0003251)	4.11490743
14	Abnormality of the renal medulla (HP:0100957)	3.43581776
15	Abnormal spermatogenesis (HP:0008669)	3.39817274
16	Recurrent otitis media (HP:0000403)	3.39565635
17	Recurrent sinusitis (HP:0011108)	3.25976347
18	Gonadotropin excess (HP:0000837)	3.13028543
19	Recurrent bronchitis (HP:0002837)	2.99499270
20	Impulsivity (HP:0100710)	2.98182271
21	Tubulointerstitial nephritis (HP:0001970)	2.94758516
22	Tubular atrophy (HP:0000092)	2.66840100
23	Abnormality of the lower motor neuron (HP:0002366)	2.54276417
24	Molar tooth sign on MRI (HP:0002419)	2.50789535
25	Abnormality of midbrain morphology (HP:0002418)	2.50789535
26	Tubulointerstitial abnormality (HP:0001969)	2.44324665
27	Azoospermia (HP:0000027)	2.26003015
28	Medial flaring of the eyebrow (HP:0010747)	2.24981102
29	Cholecystitis (HP:0001082)	2.18257184
30	Abnormal gallbladder physiology (HP:0012438)	2.18257184
31	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.14961100
32	Spastic tetraparesis (HP:0001285)	2.12967317
33	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	13.2236220
34	Absent/shortened dynein arms (HP:0200106)	13.0515383
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	13.0515383
36	Postaxial foot polydactyly (HP:0001830)	1.99973738
37	Stage 5 chronic kidney disease (HP:0003774)	1.94405675
38	Tubulointerstitial fibrosis (HP:0005576)	1.91239102
39	Amyotrophic lateral sclerosis (HP:0007354)	1.89060289
40	Heterotopia (HP:0002282)	1.87852189
41	Fibular hypoplasia (HP:0003038)	1.83616708
42	Absent frontal sinuses (HP:0002688)	1.77784333
43	Congenital hepatic fibrosis (HP:0002612)	1.76777030
44	Abnormal drinking behavior (HP:0030082)	1.75717237
45	Polydipsia (HP:0001959)	1.75717237
46	Dyschromatopsia (HP:0007641)	1.74455443
47	Short ribs (HP:0000773)	1.73972603
48	Abnormality of the renal cortex (HP:0011035)	1.73038458
49	Bell-shaped thorax (HP:0001591)	1.71876197
50	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.69913893
51	Absent epiphyses (HP:0010577)	1.69913893
52	Impaired proprioception (HP:0010831)	1.66573131
53	Renal dysplasia (HP:0000110)	1.66477945
54	Oculomotor apraxia (HP:0000657)	1.62531771
55	Choroideremia (HP:0001139)	1.61320736
56	Abnormal biliary tract physiology (HP:0012439)	1.59762706
57	Bile duct proliferation (HP:0001408)	1.59762706
58	Abnormality of renal excretion (HP:0011036)	1.59060333
59	Abnormality of dentin (HP:0010299)	1.58594647
60	Taurodontia (HP:0000679)	1.57201069
61	Abnormality of permanent molar morphology (HP:0011071)	1.57201069
62	Abnormality of the dental root (HP:0006486)	1.57201069
63	Decreased central vision (HP:0007663)	1.56959786
64	J-shaped sella turcica (HP:0002680)	1.56089026
65	Chronic sinusitis (HP:0011109)	1.54322545
66	Deformed sella turcica (HP:0002681)	1.50931677
67	Microglossia (HP:0000171)	1.50191356
68	Broad distal phalanx of finger (HP:0009836)	1.46729589
69	Abnormality of molar (HP:0011077)	1.46345760
70	Abnormality of molar morphology (HP:0011070)	1.46345760
71	Postaxial hand polydactyly (HP:0001162)	1.46143781
72	Degeneration of anterior horn cells (HP:0002398)	1.45451735
73	Abnormality of the anterior horn cell (HP:0006802)	1.45451735
74	Abnormality of the dental pulp (HP:0006479)	1.43532852
75	Short femoral neck (HP:0100864)	1.42474748
76	Facial cleft (HP:0002006)	1.41804165
77	Supernumerary spleens (HP:0009799)	1.39661996
78	Short thorax (HP:0010306)	1.39280466
79	Hemiparesis (HP:0001269)	1.35260375
80	Hemorrhage of the eye (HP:0011885)	1.33563470
81	Abnormal urine output (HP:0012590)	1.32700764
82	Neurofibrillary tangles (HP:0002185)	1.31468814
83	Cystic liver disease (HP:0006706)	1.31267075
84	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.30166885
85	Nephropathy (HP:0000112)	1.29955476
86	Upper motor neuron abnormality (HP:0002127)	1.24586974
87	Median cleft lip (HP:0000161)	1.24544738
88	Aplasia/Hypoplasia of the lens (HP:0008063)	1.23757671
89	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.22233888
90	Loss of speech (HP:0002371)	1.22142993
91	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.21816952
92	Pachygyria (HP:0001302)	1.21591420
93	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.21090619
94	Cerebellar dysplasia (HP:0007033)	1.20625420
95	Asymmetric septal hypertrophy (HP:0001670)	1.20345378
96	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.19893622
97	Bundle branch block (HP:0011710)	1.19050843
98	Personality changes (HP:0000751)	1.17085367
99	Polyuria (HP:0000103)	1.16091793
100	Abnormality of ocular smooth pursuit (HP:0000617)	1.13877457

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK3	8.25472184
2	PDK4	8.25472184
3	TESK1	5.92192004
4	PDK2	5.33470841
5	PRKD3	5.01294908
6	ICK	4.26681116
7	PNCK	2.48297538
8	PTK2B	2.32727833
9	WNK4	2.32079439
10	STK39	2.22447465
11	NEK2	1.95915970
12	STK38	1.69463749
13	DYRK1B	1.40615504
14	MAPK15	1.14101005
15	WNK1	0.99689827
16	PDK1	0.97583865
17	PASK	0.93267874
18	TYRO3	0.89169072
19	CDC7	0.84866408
20	STK3	0.83656548
21	DYRK3	0.81779096
22	CCNB1	0.77238399
23	IRAK1	0.72101136
24	CAMK1G	0.64179094
25	TTK	0.63078817
26	PINK1	0.58057519
27	CHEK2	0.52852129
28	STK38L	0.49870976
29	PDPK1	0.49643685
30	CHEK1	0.47901994
31	TESK2	0.46735677
32	BMPR1B	0.46548375
33	RIPK4	0.44612655
34	WEE1	0.41920073
35	EEF2K	0.40710097
36	LMTK2	0.39366360
37	ATR	0.39279762
38	NTRK2	0.37973266
39	MAP2K6	0.35995260
40	PAK1	0.34994316
41	MTOR	0.33424790
42	ATM	0.32879119
43	MUSK	0.32872391
44	PAK2	0.28681353
45	IRAK2	0.28204899
46	PRKCG	0.27088113
47	NEK6	0.25162556
48	MARK2	0.24855507
49	PRKAA1	0.23352298
50	PLK1	0.23299899
51	PAK4	0.22984552
52	CAMKK1	0.22039483
53	PLK4	0.21948129
54	MAPKAPK5	0.18970899
55	RPS6KB1	0.15964045
56	SRPK1	0.11243470
57	YES1	0.09643735
58	PRKCZ	0.09420586
59	CSNK2A1	0.08158623
60	EPHB1	0.07584987
61	GSK3B	0.07491219
62	CDK2	0.07277866
63	PRKCQ	0.07253454
64	CDK15	0.07092920
65	MAP3K10	0.06956703
66	CDK1	0.06878889
67	WNK3	0.06572680
68	CDK12	0.06461063
69	CDK18	0.04902461
70	TAOK1	0.04863002
71	PAK6	0.04790307
72	CSNK1D	0.04705591
73	CDK11A	0.04480394
74	AURKA	0.03401872
75	MAPK8	0.03320753
76	STK10	0.02179298
77	CDK14	0.02133320
78	PRKACB	0.02109851
79	RPS6KA1	0.01843646
80	PRKCB	0.01476561
81	PRKACG	0.01232909
82	CSNK2A2	0.01172617
83	CDK6	0.00843095
84	PRKG1	0.00051938
85	MAPK1	-0.0360822
86	PRKG2	-0.0335792
87	CSK	-0.0330391
88	CAMK2A	-0.0312229
89	CSF1R	-0.0295645
90	BRAF	-0.0267932
91	PRKCA	-0.0253659
92	MAPK10	-0.0239088
93	BRSK2	-0.0160986
94	CDK4	-0.0154747
95	EGFR	-0.0118866
96	STK11	-0.0104282
97	PRKDC	-0.0092775
98	PDGFRB	-0.0053378
99	RPS6KA3	-0.0040681
100	CDK3	-0.0009683

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	4.31438081
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.02943740
3	Pyruvate metabolism_Homo sapiens_hsa00620	3.70508427
4	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.60232242
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.98209086
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.85520458
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.76950093
8	Propanoate metabolism_Homo sapiens_hsa00640	2.72610588
9	Glucagon signaling pathway_Homo sapiens_hsa04922	2.70233122
10	Basal transcription factors_Homo sapiens_hsa03022	2.57672909
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.50379350
12	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	2.20935828
13	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.16046032
14	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.03047301
15	Glycerolipid metabolism_Homo sapiens_hsa00561	2.02855900
16	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	2.02497158
17	Oocyte meiosis_Homo sapiens_hsa04114	1.98186466
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.92483813
19	PPAR signaling pathway_Homo sapiens_hsa03320	1.82954251
20	Pentose phosphate pathway_Homo sapiens_hsa00030	1.73671140
21	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.65242482
22	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.63739937
23	Amphetamine addiction_Homo sapiens_hsa05031	1.63080022
24	Huntingtons disease_Homo sapiens_hsa05016	1.59031439
25	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.52797350
26	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.45175700
27	mRNA surveillance pathway_Homo sapiens_hsa03015	1.43843438
28	Fat digestion and absorption_Homo sapiens_hsa04975	1.36419746
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.36239408
30	RNA transport_Homo sapiens_hsa03013	1.33286218
31	Fatty acid metabolism_Homo sapiens_hsa01212	1.32008370
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.31525663
33	Carbon metabolism_Homo sapiens_hsa01200	1.28110605
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.27789217
35	Fatty acid degradation_Homo sapiens_hsa00071	1.26407786
36	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.23365224
37	Mineral absorption_Homo sapiens_hsa04978	1.21926666
38	Antigen processing and presentation_Homo sapiens_hsa04612	1.19912231
39	Renin secretion_Homo sapiens_hsa04924	1.15804179
40	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.07995078
41	Purine metabolism_Homo sapiens_hsa00230	0.99156068
42	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.91934434
43	Long-term potentiation_Homo sapiens_hsa04720	0.90487990
44	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.90444599
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88472619
46	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84767911
47	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.84095056
48	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.80658270
49	Glutathione metabolism_Homo sapiens_hsa00480	0.80502148
50	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.77388671
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.75726850
52	ABC transporters_Homo sapiens_hsa02010	0.74333788
53	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.73113511
54	Estrogen signaling pathway_Homo sapiens_hsa04915	0.72225841
55	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.70754163
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69689327
57	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.69436424
58	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.61679342
59	Insulin secretion_Homo sapiens_hsa04911	0.60711255
60	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.60257463
61	Legionellosis_Homo sapiens_hsa05134	0.58423482
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57987804
63	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.57589016
64	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.55081411
65	Bile secretion_Homo sapiens_hsa04976	0.53910261
66	Calcium signaling pathway_Homo sapiens_hsa04020	0.52801402
67	AMPK signaling pathway_Homo sapiens_hsa04152	0.50487613
68	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.46442958
69	Endocytosis_Homo sapiens_hsa04144	0.45908847
70	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.42762542
71	VEGF signaling pathway_Homo sapiens_hsa04370	0.41665820
72	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.39402158
73	RNA degradation_Homo sapiens_hsa03018	0.37155754
74	Pancreatic secretion_Homo sapiens_hsa04972	0.37017468
75	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.34651389
76	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.34363234
77	Metabolic pathways_Homo sapiens_hsa01100	0.33807552
78	Protein digestion and absorption_Homo sapiens_hsa04974	0.33264829
79	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.33180932
80	Alcoholism_Homo sapiens_hsa05034	0.32755144
81	Taste transduction_Homo sapiens_hsa04742	0.31618698
82	Gastric acid secretion_Homo sapiens_hsa04971	0.31372501
83	Salivary secretion_Homo sapiens_hsa04970	0.31304862
84	Renin-angiotensin system_Homo sapiens_hsa04614	0.30646916
85	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.29987159
86	Pyrimidine metabolism_Homo sapiens_hsa00240	0.28770810
87	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.28371683
88	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.27331402
89	Circadian entrainment_Homo sapiens_hsa04713	0.27244318
90	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.25829001
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.25431394
92	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.24998791
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.21812012
94	Wnt signaling pathway_Homo sapiens_hsa04310	0.18436986
95	Cocaine addiction_Homo sapiens_hsa05030	0.16704968
96	Viral carcinogenesis_Homo sapiens_hsa05203	0.15216509
97	Sphingolipid metabolism_Homo sapiens_hsa00600	0.13607744
98	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.13575054
99	Basal cell carcinoma_Homo sapiens_hsa05217	0.12615952
100	Retinol metabolism_Homo sapiens_hsa00830	0.12126661

POM121L12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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