POM121L14P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.54749359
2sperm motility (GO:0030317)6.61873342
3rRNA methylation (GO:0031167)6.37873061
4acrosome reaction (GO:0007340)6.37703465
5rRNA modification (GO:0000154)5.62929138
6fusion of sperm to egg plasma membrane (GO:0007342)5.23012951
7cellular ketone body metabolic process (GO:0046950)5.17241948
8behavioral response to nicotine (GO:0035095)4.83577332
9spermatid development (GO:0007286)4.76646648
10lactate metabolic process (GO:0006089)4.71317123
11ketone body metabolic process (GO:1902224)4.51274670
12protein polyglutamylation (GO:0018095)4.49984211
13RNA destabilization (GO:0050779)4.37544075
14microtubule depolymerization (GO:0007019)4.30941656
15bone trabecula formation (GO:0060346)4.28079832
16estrogen biosynthetic process (GO:0006703)4.23151122
17protein targeting to Golgi (GO:0000042)4.22946889
18establishment of protein localization to Golgi (GO:0072600)4.22588620
19phosphatidylethanolamine biosynthetic process (GO:0006646)4.02925507
20calcium ion-dependent exocytosis (GO:0017156)4.00968740
21single strand break repair (GO:0000012)3.97471611
22plasma membrane fusion (GO:0045026)3.96103888
23cell wall macromolecule catabolic process (GO:0016998)3.93461811
24positive regulation of cell cycle G2/M phase transition (GO:1902751)3.91751548
25positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.91751548
26Golgi to endosome transport (GO:0006895)3.81886132
27urinary tract smooth muscle contraction (GO:0014848)3.80726980
28protein localization to Golgi apparatus (GO:0034067)3.80341961
29somite rostral/caudal axis specification (GO:0032525)3.76542454
30retrograde transport, vesicle recycling within Golgi (GO:0000301)3.71584371
31spermatogenesis (GO:0007283)3.71522278
32male gamete generation (GO:0048232)3.70349398
33positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.69549398
34multicellular organism reproduction (GO:0032504)3.68717949
35sleep (GO:0030431)3.67926743
36phosphatidylethanolamine metabolic process (GO:0046337)3.65560295
37hematopoietic stem cell proliferation (GO:0071425)3.64007761
38sperm-egg recognition (GO:0035036)3.63535153
39regulation of neurotransmitter uptake (GO:0051580)3.62026588
40microtubule polymerization or depolymerization (GO:0031109)3.53188294
41spermatid nucleus differentiation (GO:0007289)3.50868837
42regulation of cilium movement (GO:0003352)3.48334431
43negative regulation of circadian rhythm (GO:0042754)3.45221046
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43103323
45negative regulation of Rho protein signal transduction (GO:0035024)3.40534918
46gamete generation (GO:0007276)3.39350207
47neuronal action potential (GO:0019228)3.38583977
48DNA packaging (GO:0006323)3.35195376
49cell wall macromolecule metabolic process (GO:0044036)3.34957325
50sperm capacitation (GO:0048240)3.33340386
51chromosome condensation (GO:0030261)3.32068171
52positive regulation of protein kinase C signaling (GO:0090037)3.24503709
53response to parathyroid hormone (GO:0071107)3.22891235
54seminiferous tubule development (GO:0072520)3.21056115
55coenzyme catabolic process (GO:0009109)3.20839540
56regulation of action potential (GO:0098900)3.20422767
57neural tube formation (GO:0001841)3.17634488
58positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.16340683
59glycerol ether metabolic process (GO:0006662)3.12979637
60positive regulation of fatty acid transport (GO:2000193)3.09733455
61cell-cell recognition (GO:0009988)3.01707615
62NAD biosynthetic process (GO:0009435)3.01260635
63DNA deamination (GO:0045006)3.00914532
64respiratory chain complex IV assembly (GO:0008535)2.97502369
65ether metabolic process (GO:0018904)2.96997155
66reproduction (GO:0000003)2.94384784
67binding of sperm to zona pellucida (GO:0007339)2.93456239
68negative regulation of translation, ncRNA-mediated (GO:0040033)2.93388228
69regulation of translation, ncRNA-mediated (GO:0045974)2.93388228
70negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.93388228
71water-soluble vitamin biosynthetic process (GO:0042364)2.92666388
72positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.91371636
73regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.91371636
74cytochrome complex assembly (GO:0017004)2.90336528
75positive regulation of Rab GTPase activity (GO:0032851)2.84563963
76regulation of Rab GTPase activity (GO:0032313)2.84563963
77ribosome assembly (GO:0042255)2.82592397
78positive regulation of DNA-templated transcription, initiation (GO:2000144)2.82325627
79cilium or flagellum-dependent cell motility (GO:0001539)2.81184473
80positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.79360910
81regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.79360910
82L-fucose catabolic process (GO:0042355)2.78560081
83fucose catabolic process (GO:0019317)2.78560081
84L-fucose metabolic process (GO:0042354)2.78560081
85epithelial cilium movement (GO:0003351)2.77923982
86centriole replication (GO:0007099)2.77820261
87positive regulation of hair follicle development (GO:0051798)2.77308908
88positive regulation of hair cycle (GO:0042635)2.77308908
89negative regulation of execution phase of apoptosis (GO:1900118)2.76971409
90axonemal dynein complex assembly (GO:0070286)2.73075675
91kidney morphogenesis (GO:0060993)2.71778465
92synaptic transmission, cholinergic (GO:0007271)2.71692763
93glial cell proliferation (GO:0014009)2.71124148
94chromatin silencing (GO:0006342)2.70850264
95phenylpropanoid metabolic process (GO:0009698)2.67252353
96cerebral cortex radially oriented cell migration (GO:0021799)2.67172614
97multicellular organismal reproductive process (GO:0048609)2.66400260
98positive regulation of organic acid transport (GO:0032892)2.63060202
99negative regulation of transcription regulatory region DNA binding (GO:2000678)2.62959655
100glyoxylate metabolic process (GO:0046487)2.61902361

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.68541201
2EZH2_22144423_ChIP-Seq_EOC_Human2.91452575
3TAF15_26573619_Chip-Seq_HEK293_Human2.84675048
4FUS_26573619_Chip-Seq_HEK293_Human2.83443914
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77221220
6CTBP1_25329375_ChIP-Seq_LNCAP_Human2.76858680
7GBX2_23144817_ChIP-Seq_PC3_Human2.59451786
8VDR_22108803_ChIP-Seq_LS180_Human2.58520604
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57019516
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.54544873
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.28367223
12P300_19829295_ChIP-Seq_ESCs_Human2.14800134
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04729745
14POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.04045774
15TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04045774
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.94010944
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.91715976
18IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.87336403
19CBP_20019798_ChIP-Seq_JUKART_Human1.87336403
20ER_23166858_ChIP-Seq_MCF-7_Human1.84809849
21SMAD3_21741376_ChIP-Seq_EPCs_Human1.77546378
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77089219
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75608154
24IRF1_19129219_ChIP-ChIP_H3396_Human1.75223750
25IGF1R_20145208_ChIP-Seq_DFB_Human1.74186451
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73551430
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69995524
28NANOG_19829295_ChIP-Seq_ESCs_Human1.69774437
29SOX2_19829295_ChIP-Seq_ESCs_Human1.69774437
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68989030
31DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.59901536
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54739774
33VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.51018273
34BCAT_22108803_ChIP-Seq_LS180_Human1.50768890
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49672389
36ETV2_25802403_ChIP-Seq_MESCs_Mouse1.49542944
37AR_25329375_ChIP-Seq_VCAP_Human1.48671988
38EWS_26573619_Chip-Seq_HEK293_Human1.47488544
39TP53_22573176_ChIP-Seq_HFKS_Human1.45915290
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.45325897
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44903080
42WDR5_24793694_ChIP-Seq_LNCAP_Human1.44229291
43ERA_21632823_ChIP-Seq_H3396_Human1.42739293
44DROSHA_22980978_ChIP-Seq_HELA_Human1.41463493
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39170417
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.37397655
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.37283966
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37267829
49REST_21632747_ChIP-Seq_MESCs_Mouse1.35196906
50TCF4_22108803_ChIP-Seq_LS180_Human1.33496892
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33161669
52HOXB7_26014856_ChIP-Seq_BT474_Human1.32231105
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30439250
54RUNX2_22187159_ChIP-Seq_PCA_Human1.29553035
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.28074038
56SMAD4_21741376_ChIP-Seq_EPCs_Human1.26584668
57TAF2_19829295_ChIP-Seq_ESCs_Human1.25844064
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24417102
59SMAD4_21799915_ChIP-Seq_A2780_Human1.24223659
60NANOG_20526341_ChIP-Seq_ESCs_Human1.22485606
61STAT3_23295773_ChIP-Seq_U87_Human1.21432942
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.21167034
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20218950
64CBX2_22325352_ChIP-Seq_293T-Rex_Human1.19668334
65EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17267577
66NCOR_22424771_ChIP-Seq_293T_Human1.16460273
67EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.16414169
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.14463121
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13758196
70RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12770865
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11841137
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10711202
73MYC_19829295_ChIP-Seq_ESCs_Human1.10147876
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09742572
75ETV1_20927104_ChIP-Seq_GIST48_Human1.09545991
76SMAD4_21741376_ChIP-Seq_HESCs_Human1.08989328
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07678323
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07403824
79OCT4_20526341_ChIP-Seq_ESCs_Human1.06911645
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06795253
81SMRT_27268052_Chip-Seq_Bcells_Human1.06374990
82CDX2_22108803_ChIP-Seq_LS180_Human1.05262393
83RBPJ_21746931_ChIP-Seq_IB4_Human1.05171178
84PHF8_20622853_ChIP-Seq_HELA_Human1.04357333
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03716418
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02711863
87TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02257861
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01787955
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01518994
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00841714
91HNFA_21074721_ChIP-Seq_CACO-2_Human1.00725352
92TP53_18474530_ChIP-ChIP_U2OS_Human1.00375147
93KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99983040
94FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99886866
95FOXA1_25329375_ChIP-Seq_VCAP_Human0.99886866
96TCF4_23295773_ChIP-Seq_U87_Human0.99581351
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.97608740
98MYC_18940864_ChIP-ChIP_HL60_Human0.96778600
99SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95679451
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95464385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.30157820
2MP0000569_abnormal_digit_pigmentation4.57844510
3MP0008995_early_reproductive_senescence4.14412501
4MP0008877_abnormal_DNA_methylation2.97821320
5MP0002822_catalepsy2.96547052
6MP0005174_abnormal_tail_pigmentation2.82283144
7MP0008961_abnormal_basal_metabolism2.71100410
8MP0005423_abnormal_somatic_nervous2.69867722
9MP0002736_abnormal_nociception_after2.32396404
10MP0002638_abnormal_pupillary_reflex2.31982594
11MP0001501_abnormal_sleep_pattern2.31902135
12MP0001968_abnormal_touch/_nociception2.23428936
13MP0003698_abnormal_male_reproductive2.08612789
14MP0005377_hearing/vestibular/ear_phenot2.00143926
15MP0003878_abnormal_ear_physiology2.00143926
16MP0002234_abnormal_pharynx_morphology1.88955024
17MP0003011_delayed_dark_adaptation1.86825669
18MP0001929_abnormal_gametogenesis1.84012055
19MP0000613_abnormal_salivary_gland1.81118445
20MP0002254_reproductive_system_inflammat1.78429566
21MP0003890_abnormal_embryonic-extraembry1.75678080
22MP0005551_abnormal_eye_electrophysiolog1.73016264
23MP0005645_abnormal_hypothalamus_physiol1.68569982
24MP0001486_abnormal_startle_reflex1.67180972
25MP0001764_abnormal_homeostasis1.65763275
26MP0002938_white_spotting1.51611627
27MP0000015_abnormal_ear_pigmentation1.50621204
28MP0001986_abnormal_taste_sensitivity1.48570262
29MP0002928_abnormal_bile_duct1.44991996
30MP0005084_abnormal_gallbladder_morpholo1.43822555
31MP0005636_abnormal_mineral_homeostasis1.41084158
32MP0005379_endocrine/exocrine_gland_phen1.40827590
33MP0005365_abnormal_bile_salt1.38743681
34MP0005253_abnormal_eye_physiology1.33741655
35MP0002837_dystrophic_cardiac_calcinosis1.33441618
36MP0004484_altered_response_of1.31723500
37MP0001765_abnormal_ion_homeostasis1.28505786
38MP0003137_abnormal_impulse_conducting1.28079828
39MP0009046_muscle_twitch1.26692571
40MP0002909_abnormal_adrenal_gland1.21029721
41MP0003880_abnormal_central_pattern1.19996002
42MP0001756_abnormal_urination1.19362898
43MP0005075_abnormal_melanosome_morpholog1.13316876
44MP0005187_abnormal_penis_morphology1.09702970
45MP0000631_abnormal_neuroendocrine_gland1.09565868
46MP0003195_calcinosis1.08777899
47MP0005310_abnormal_salivary_gland1.06922729
48MP0003786_premature_aging1.06775201
49MP0002161_abnormal_fertility/fecundity1.05367304
50MP0003136_yellow_coat_color1.03004975
51MP0006276_abnormal_autonomic_nervous1.02960263
52MP0009745_abnormal_behavioral_response1.02812545
53MP0004742_abnormal_vestibular_system1.01446108
54MP0002272_abnormal_nervous_system0.99519205
55MP0001502_abnormal_circadian_rhythm0.98658475
56MP0004085_abnormal_heartbeat0.96713913
57MP0002229_neurodegeneration0.94916746
58MP0005332_abnormal_amino_acid0.92252748
59MP0002210_abnormal_sex_determination0.91758387
60MP0004043_abnormal_pH_regulation0.91700738
61MP0005646_abnormal_pituitary_gland0.91061494
62MP0000653_abnormal_sex_gland0.89129756
63MP0001984_abnormal_olfaction0.88199719
64MP0008058_abnormal_DNA_repair0.87202868
65MP0002163_abnormal_gland_morphology0.85293208
66MP0002735_abnormal_chemical_nociception0.85231849
67MP0003119_abnormal_digestive_system0.85006065
68MP0004133_heterotaxia0.84904387
69MP0002102_abnormal_ear_morphology0.84724719
70MP0003718_maternal_effect0.84363990
71MP0006036_abnormal_mitochondrial_physio0.84351404
72MP0008875_abnormal_xenobiotic_pharmacok0.84267845
73MP0000647_abnormal_sebaceous_gland0.83757615
74MP0002557_abnormal_social/conspecific_i0.83737145
75MP0002067_abnormal_sensory_capabilities0.82895274
76MP0001485_abnormal_pinna_reflex0.82891763
77MP0002095_abnormal_skin_pigmentation0.82079431
78MP0002653_abnormal_ependyma_morphology0.81478195
79MP0002572_abnormal_emotion/affect_behav0.80330649
80MP0001970_abnormal_pain_threshold0.80246208
81MP0004019_abnormal_vitamin_homeostasis0.80066082
82MP0000467_abnormal_esophagus_morphology0.80003458
83MP0001188_hyperpigmentation0.79714608
84MP0001324_abnormal_eye_pigmentation0.79685409
85MP0005670_abnormal_white_adipose0.78250220
86MP0006072_abnormal_retinal_apoptosis0.76851213
87MP0001145_abnormal_male_reproductive0.76664940
88MP0002733_abnormal_thermal_nociception0.76492811
89MP0005671_abnormal_response_to0.76470203
90MP0002693_abnormal_pancreas_physiology0.76461474
91MP0001963_abnormal_hearing_physiology0.76283306
92MP0000026_abnormal_inner_ear0.75736422
93MP0004859_abnormal_synaptic_plasticity0.74709152
94MP0000230_abnormal_systemic_arterial0.72001559
95MP0002752_abnormal_somatic_nervous0.70484311
96MP0002127_abnormal_cardiovascular_syste0.70192252
97MP0002184_abnormal_innervation0.70141461
98MP0004885_abnormal_endolymph0.68728146
99MP0009764_decreased_sensitivity_to0.68464885
100MP0003172_abnormal_lysosome_physiology0.68038775

Predicted human phenotypes

RankGene SetZ-score
1Oligodactyly (hands) (HP:0001180)6.72612728
2Oligodactyly (HP:0012165)4.66891088
3Severe visual impairment (HP:0001141)4.55741977
4Attenuation of retinal blood vessels (HP:0007843)4.19279255
5Intestinal atresia (HP:0011100)3.76421044
6Anal stenosis (HP:0002025)3.71538912
7Absent thumb (HP:0009777)3.45787548
8Broad-based gait (HP:0002136)3.45357374
9Bony spicule pigmentary retinopathy (HP:0007737)3.42462622
10Abnormality of the parathyroid morphology (HP:0011766)3.25067289
11Aqueductal stenosis (HP:0002410)3.22673895
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.19017071
13Impulsivity (HP:0100710)3.16309670
14Congenital malformation of the right heart (HP:0011723)3.12609022
15Double outlet right ventricle (HP:0001719)3.12609022
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.11547015
17Congenital stationary night blindness (HP:0007642)3.03856904
18Abnormal rod and cone electroretinograms (HP:0008323)3.01108306
19Pendular nystagmus (HP:0012043)2.91438639
20Labial hypoplasia (HP:0000066)2.82724719
21Popliteal pterygium (HP:0009756)2.81215681
22Split foot (HP:0001839)2.80233607
23Pancreatic fibrosis (HP:0100732)2.80045281
24True hermaphroditism (HP:0010459)2.71218668
25Clumsiness (HP:0002312)2.67896532
26Pancreatic cysts (HP:0001737)2.67751793
27Progressive inability to walk (HP:0002505)2.61254513
28Absent/shortened dynein arms (HP:0200106)2.58197988
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.58197988
30Abnormality of macular pigmentation (HP:0008002)2.56667601
31Chromsome breakage (HP:0040012)2.56208137
32Clubbing of toes (HP:0100760)2.55139581
33Hypoplastic female external genitalia (HP:0012815)2.53650602
34Meckel diverticulum (HP:0002245)2.53055969
35Gaze-evoked nystagmus (HP:0000640)2.53042355
36Abnormality of the ileum (HP:0001549)2.45301010
37Hypoplastic labia majora (HP:0000059)2.41658123
38Intention tremor (HP:0002080)2.37569264
39Abnormality of the labia majora (HP:0012881)2.36300739
40Abnormality of the preputium (HP:0100587)2.30545169
41Gastrointestinal atresia (HP:0002589)2.21833220
42Cleft eyelid (HP:0000625)2.15931126
43Hyperinsulinemic hypoglycemia (HP:0000825)2.15082214
44Cupped ear (HP:0000378)2.12263468
45Abnormality of the renal cortex (HP:0011035)2.11099630
46Nephronophthisis (HP:0000090)2.10085704
47Progressive cerebellar ataxia (HP:0002073)2.09818765
48Rib fusion (HP:0000902)2.09443590
49Male pseudohermaphroditism (HP:0000037)2.07724966
50Anencephaly (HP:0002323)2.07703078
51Bulbous nose (HP:0000414)2.07250969
52Abnormality of the labia (HP:0000058)2.05271287
53Decreased central vision (HP:0007663)2.03085967
54Stomach cancer (HP:0012126)2.02643400
55Aplastic anemia (HP:0001915)2.01353371
56Nephrogenic diabetes insipidus (HP:0009806)2.01072940
57Macular degeneration (HP:0000608)2.00247270
58Absent forearm bone (HP:0003953)1.95529292
59Aplasia involving forearm bones (HP:0009822)1.95529292
60Esophageal atresia (HP:0002032)1.94791032
61Hyperventilation (HP:0002883)1.94090894
62Cystic liver disease (HP:0006706)1.91304530
63Aplasia/Hypoplasia of the earlobes (HP:0009906)1.91123176
64Renal cortical cysts (HP:0000803)1.90635620
65Dysdiadochokinesis (HP:0002075)1.90211095
66Abnormality of chromosome stability (HP:0003220)1.89519727
67Abnormality of the duodenum (HP:0002246)1.89238473
68Unilateral renal agenesis (HP:0000122)1.88318491
69Amelogenesis imperfecta (HP:0000705)1.87409270
70Decreased circulating renin level (HP:0003351)1.86223033
71Abolished electroretinogram (ERG) (HP:0000550)1.86199833
72Medial flaring of the eyebrow (HP:0010747)1.86090873
73Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.85292420
74Absent radius (HP:0003974)1.83937135
75Inability to walk (HP:0002540)1.83925836
76Abnormal ciliary motility (HP:0012262)1.83056822
77Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82930499
78Infertility (HP:0000789)1.82179116
79Hyperglycinemia (HP:0002154)1.78701833
80Constricted visual fields (HP:0001133)1.78646120
81Nonprogressive disorder (HP:0003680)1.78323963
82Potter facies (HP:0002009)1.77831947
83Facial shape deformation (HP:0011334)1.77831947
84Abnormal drinking behavior (HP:0030082)1.76086033
85Polydipsia (HP:0001959)1.76086033
86Oligohydramnios (HP:0001562)1.75951724
87Abnormal sex determination (HP:0012244)1.75411156
88Sex reversal (HP:0012245)1.75411156
89Abnormal respiratory epithelium morphology (HP:0012253)1.75142932
90Abnormal respiratory motile cilium morphology (HP:0005938)1.75142932
91Abnormality of midbrain morphology (HP:0002418)1.74450443
92Molar tooth sign on MRI (HP:0002419)1.74450443
93Palpebral edema (HP:0100540)1.73398453
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71918834
95Abnormality of alanine metabolism (HP:0010916)1.71918834
96Hyperalaninemia (HP:0003348)1.71918834
97Polyuria (HP:0000103)1.71629681
98Abnormality of the renal medulla (HP:0100957)1.71596709
99Short thumb (HP:0009778)1.70708156
100Renal agenesis (HP:0000104)1.70490583

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.36325088
2TNIK4.97754566
3INSRR3.70153654
4ZAK3.43742312
5MAP3K23.39681627
6FRK3.35806452
7PLK42.86977028
8MAP3K32.59738089
9ADRBK22.45552835
10TLK12.25423945
11TAOK32.05577366
12GRK11.99200967
13NUAK11.85370375
14MST41.84046562
15PINK11.65831335
16STK381.54278917
17WNK41.52849971
18CASK1.43745145
19WNK31.40129650
20FLT31.35918374
21GRK61.32141818
22WNK11.27073942
23PLK21.26725283
24BCKDK1.22299408
25TNK21.22289525
26MAPK151.22040483
27NLK1.18867519
28BMPR1B1.12338380
29MAPK131.09489840
30MAP3K91.08140954
31MAP3K71.06131488
32TESK11.02533397
33NTRK21.02250360
34DAPK21.00712086
35BLK0.95109077
36FGFR20.94664455
37MAPKAPK50.94550961
38STK38L0.91766249
39STK240.84532558
40ACVR1B0.81093834
41BCR0.79638915
42NTRK30.77258334
43PASK0.75763250
44PHKG20.73767434
45PHKG10.73767434
46RPS6KA10.72601851
47PRKCG0.71816019
48IKBKE0.71463320
49PRKG10.67195943
50CAMK1G0.67126261
51IRAK40.65501493
52PRKCQ0.63846735
53SGK4940.61042855
54SGK2230.61042855
55SGK20.59435276
56PAK30.57593250
57TEC0.55810500
58DYRK20.53681538
59MAP2K60.53542929
60BRD40.52352987
61MAP3K60.50982974
62MAP3K40.48526109
63TRPM70.47571315
64PRKAA20.45916090
65ZAP700.41877452
66RPS6KA20.41869047
67STK110.40987452
68ADRBK10.40824824
69DYRK30.39634771
70MAP2K20.38484720
71PNCK0.38012427
72CAMK1D0.36912644
73LCK0.36810866
74VRK10.36349832
75IKBKB0.36343656
76CDK30.35459848
77MAP2K40.34825631
78PRKACB0.33914318
79TXK0.33911809
80STK390.32579145
81ITK0.32398423
82JAK30.31202291
83CSNK1D0.31199801
84RPS6KA60.29902303
85TRIM280.29832647
86SYK0.29203685
87PRKD20.27265856
88PRKCE0.27159871
89TIE10.26927101
90PTK2B0.26495647
91OXSR10.25164168
92MAP3K140.23736736
93HIPK20.21914318
94MAP2K70.21622564
95LYN0.21515503
96PAK60.20322010
97DDR20.20289534
98EIF2AK10.20153976
99PRKACA0.20116573
100MUSK0.20034217

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.49054458
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.89704850
3Fanconi anemia pathway_Homo sapiens_hsa034602.83759006
4Butanoate metabolism_Homo sapiens_hsa006502.52618730
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.35542005
6Nicotine addiction_Homo sapiens_hsa050332.35513489
7Vitamin B6 metabolism_Homo sapiens_hsa007502.32477590
8Homologous recombination_Homo sapiens_hsa034402.24310610
9Linoleic acid metabolism_Homo sapiens_hsa005912.23992084
10Fatty acid biosynthesis_Homo sapiens_hsa000612.20384683
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07103305
12Phototransduction_Homo sapiens_hsa047442.05212754
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00729211
14Propanoate metabolism_Homo sapiens_hsa006401.94576900
15Circadian rhythm_Homo sapiens_hsa047101.93842266
16Peroxisome_Homo sapiens_hsa041461.81275151
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.78053141
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74187357
19Taste transduction_Homo sapiens_hsa047421.72609933
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71289094
21Regulation of autophagy_Homo sapiens_hsa041401.68096326
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.62490269
23Selenocompound metabolism_Homo sapiens_hsa004501.57961540
24Ether lipid metabolism_Homo sapiens_hsa005651.57226143
25Fatty acid metabolism_Homo sapiens_hsa012121.53237541
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51386064
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.46465278
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44741075
29RNA polymerase_Homo sapiens_hsa030201.43208428
30Type I diabetes mellitus_Homo sapiens_hsa049401.39517736
31Circadian entrainment_Homo sapiens_hsa047131.38447881
32Olfactory transduction_Homo sapiens_hsa047401.36954880
33Tryptophan metabolism_Homo sapiens_hsa003801.32293239
34One carbon pool by folate_Homo sapiens_hsa006701.29751248
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.25438345
36Basal transcription factors_Homo sapiens_hsa030221.20764118
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.18995903
38Hedgehog signaling pathway_Homo sapiens_hsa043401.17362034
39Graft-versus-host disease_Homo sapiens_hsa053321.17127113
40Insulin secretion_Homo sapiens_hsa049111.16093090
41RNA degradation_Homo sapiens_hsa030181.15866436
42Sulfur metabolism_Homo sapiens_hsa009201.13413582
43Basal cell carcinoma_Homo sapiens_hsa052171.09466531
44Arachidonic acid metabolism_Homo sapiens_hsa005901.07840953
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05037323
46Fatty acid degradation_Homo sapiens_hsa000711.00594942
47Purine metabolism_Homo sapiens_hsa002300.90923629
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90234137
49Retinol metabolism_Homo sapiens_hsa008300.89146229
50Pyruvate metabolism_Homo sapiens_hsa006200.85946272
51Nitrogen metabolism_Homo sapiens_hsa009100.84367748
52Morphine addiction_Homo sapiens_hsa050320.82687384
53Dorso-ventral axis formation_Homo sapiens_hsa043200.79986461
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77172083
55Antigen processing and presentation_Homo sapiens_hsa046120.76471596
56Salivary secretion_Homo sapiens_hsa049700.74574908
57Calcium signaling pathway_Homo sapiens_hsa040200.73435823
58Amphetamine addiction_Homo sapiens_hsa050310.71678428
59Chemical carcinogenesis_Homo sapiens_hsa052040.66605550
60Vitamin digestion and absorption_Homo sapiens_hsa049770.64631831
61Renin secretion_Homo sapiens_hsa049240.63954194
62Type II diabetes mellitus_Homo sapiens_hsa049300.63516495
63Metabolic pathways_Homo sapiens_hsa011000.62976608
64Sphingolipid metabolism_Homo sapiens_hsa006000.61853069
65cAMP signaling pathway_Homo sapiens_hsa040240.61630862
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.60868334
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60554394
68Caffeine metabolism_Homo sapiens_hsa002320.59782697
69Steroid biosynthesis_Homo sapiens_hsa001000.59279207
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57819703
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57533081
72Autoimmune thyroid disease_Homo sapiens_hsa053200.56536536
73Cocaine addiction_Homo sapiens_hsa050300.53936167
74Allograft rejection_Homo sapiens_hsa053300.53738070
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47950214
76ABC transporters_Homo sapiens_hsa020100.45232348
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.44310285
78Cardiac muscle contraction_Homo sapiens_hsa042600.42568831
79Oocyte meiosis_Homo sapiens_hsa041140.42092020
80Gastric acid secretion_Homo sapiens_hsa049710.42067943
81Oxidative phosphorylation_Homo sapiens_hsa001900.41135134
82Fatty acid elongation_Homo sapiens_hsa000620.39534751
83Primary immunodeficiency_Homo sapiens_hsa053400.38178536
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36132318
85Glutamatergic synapse_Homo sapiens_hsa047240.35802414
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34721229
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33832205
88Non-homologous end-joining_Homo sapiens_hsa034500.30901251
89Pyrimidine metabolism_Homo sapiens_hsa002400.30221651
90Parkinsons disease_Homo sapiens_hsa050120.28646877
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27816202
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27502888
93Glucagon signaling pathway_Homo sapiens_hsa049220.27185163
94Inositol phosphate metabolism_Homo sapiens_hsa005620.26687969
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26156816
96Huntingtons disease_Homo sapiens_hsa050160.25142629
97Serotonergic synapse_Homo sapiens_hsa047260.23788446
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23727444
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23617044
100Proteasome_Homo sapiens_hsa030500.23139710

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