ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cell-cell recognition (GO:0009988)	9.76434841
2	acrosome assembly (GO:0001675)	9.69822688
3	epithelial cilium movement (GO:0003351)	9.45163825
4	regulation of cilium movement (GO:0003352)	9.41589746
5	spermatid development (GO:0007286)	9.28098385
6	plasma membrane fusion (GO:0045026)	9.15384949
7	cell wall macromolecule metabolic process (GO:0044036)	8.73219064
8	cell wall macromolecule catabolic process (GO:0016998)	8.73219064
9	reproduction (GO:0000003)	8.45551945
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	8.25106984
11	male meiosis (GO:0007140)	8.03385151
12	cilium movement (GO:0003341)	7.86469086
13	synaptonemal complex organization (GO:0070193)	7.81174789
14	synaptonemal complex assembly (GO:0007130)	7.36493018
15	single fertilization (GO:0007338)	7.03143825
16	DNA methylation involved in gamete generation (GO:0043046)	6.63543092
17	negative regulation of inclusion body assembly (GO:0090084)	6.50636537
18	sperm capacitation (GO:0048240)	6.50488451
19	microtubule depolymerization (GO:0007019)	6.26054475
20	spermatogenesis (GO:0007283)	6.19806289
21	male gamete generation (GO:0048232)	6.17456204
22	fertilization (GO:0009566)	6.08782783
23	male meiosis I (GO:0007141)	5.79178455
24	organic cation transport (GO:0015695)	5.74321538
25	gamete generation (GO:0007276)	5.67161872
26	regulation of microtubule-based movement (GO:0060632)	5.56128334
27	germ cell development (GO:0007281)	5.32932693
28	regulation of inclusion body assembly (GO:0090083)	5.29237148
29	chromosome organization involved in meiosis (GO:0070192)	5.21708170
30	cellular process involved in reproduction in multicellular organism (GO:0022412)	5.21455797
31	left/right pattern formation (GO:0060972)	5.14301292
32	calcium ion-dependent exocytosis (GO:0017156)	5.12700802
33	ventricular system development (GO:0021591)	5.06172967
34	meiotic nuclear division (GO:0007126)	5.03995260
35	seminiferous tubule development (GO:0072520)	4.90872148
36	meiotic cell cycle (GO:0051321)	4.80951978
37	microtubule severing (GO:0051013)	4.80221846
38	cell recognition (GO:0008037)	4.74596386
39	meiosis I (GO:0007127)	4.66144071
40	gene silencing by RNA (GO:0031047)	4.58823887
41	multicellular organismal reproductive process (GO:0048609)	4.46179255
42	protein localization to cilium (GO:0061512)	4.24615988
43	protein polyglutamylation (GO:0018095)	4.01425712
44	carnitine transport (GO:0015879)	3.90047005
45	amino-acid betaine transport (GO:0015838)	3.90047005
46	carnitine transmembrane transport (GO:1902603)	3.89834221
47	regulation of spindle checkpoint (GO:0090231)	3.66330560
48	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	3.61424275
49	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	3.61424275
50	multicellular organismal development (GO:0007275)	3.59689942
51	chaperone-mediated protein complex assembly (GO:0051131)	3.59647472
52	glycerol ether metabolic process (GO:0006662)	3.58561132
53	genitalia morphogenesis (GO:0035112)	3.47323971
54	mitotic sister chromatid cohesion (GO:0007064)	3.42975661
55	polyol catabolic process (GO:0046174)	3.41936342
56	peptidyl-glutamic acid modification (GO:0018200)	3.36545707
57	chromosome condensation (GO:0030261)	3.32886859
58	ether metabolic process (GO:0018904)	3.29897608
59	DNA packaging (GO:0006323)	3.29311546
60	interferon-gamma secretion (GO:0072643)	3.27910449
61	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	3.23968755
62	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	3.23968755
63	synapsis (GO:0007129)	3.23610490
64	alditol metabolic process (GO:0019400)	3.20019627
65	negative regulation of organelle assembly (GO:1902116)	3.19790470
66	gene silencing (GO:0016458)	3.19600808
67	microtubule polymerization or depolymerization (GO:0031109)	3.18155103
68	meiotic cell cycle process (GO:1903046)	3.16617220
69	cilium morphogenesis (GO:0060271)	3.12532070
70	monoubiquitinated protein deubiquitination (GO:0035520)	3.10965412
71	regulation of meiosis I (GO:0060631)	3.09031041
72	intraciliary transport (GO:0042073)	3.04033473
73	protein refolding (GO:0042026)	3.03248423
74	microtubule-based movement (GO:0007018)	3.01714721
75	RNA localization (GO:0006403)	2.95853889
76	cilium organization (GO:0044782)	2.95759460
77	negative regulation of skeletal muscle tissue development (GO:0048642)	2.89972635
78	nucleosome disassembly (GO:0006337)	2.89424757
79	protein-DNA complex disassembly (GO:0032986)	2.89424757
80	axoneme assembly (GO:0035082)	2.89209161
81	spermatid nucleus differentiation (GO:0007289)	2.86395799
82	cilium assembly (GO:0042384)	2.85171358
83	positive regulation of mRNA 3-end processing (GO:0031442)	2.76877481
84	glycerol metabolic process (GO:0006071)	2.75164514
85	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.74865129
86	cellular response to arsenic-containing substance (GO:0071243)	2.73760166
87	quaternary ammonium group transport (GO:0015697)	2.73445725
88	RNA destabilization (GO:0050779)	2.72036190
89	nucleus organization (GO:0006997)	2.71549227
90	cellular component assembly involved in morphogenesis (GO:0010927)	2.68141330
91	sperm motility (GO:0030317)	12.5608159
92	fusion of sperm to egg plasma membrane (GO:0007342)	12.0334875
93	cilium or flagellum-dependent cell motility (GO:0001539)	11.6520566
94	axonemal dynein complex assembly (GO:0070286)	11.5795163
95	acrosome reaction (GO:0007340)	11.5177085
96	piRNA metabolic process (GO:0034587)	11.0518956
97	sperm-egg recognition (GO:0035036)	10.9206462
98	motile cilium assembly (GO:0044458)	10.7179482
99	multicellular organism reproduction (GO:0032504)	10.3959957
100	binding of sperm to zona pellucida (GO:0007339)	10.1175160

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.95467542
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.33637337
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.31555485
4	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.57283116
5	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.40603549
6	* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	2.35125916
7	GATA1_26923725_Chip-Seq_HPCs_Mouse	2.19679093
8	VDR_22108803_ChIP-Seq_LS180_Human	2.17065814
9	ELK4_26923725_Chip-Seq_MESODERM_Mouse	2.02444239
10	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	11.7038794
11	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.86385541
12	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.82209215
13	ZNF274_21170338_ChIP-Seq_K562_Hela	1.80908758
14	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.73550129
15	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.73174125
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.63389441
17	* STAT1_17558387_ChIP-Seq_HELA_Human	1.56778544
18	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.55873497
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.50920037
20	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.50497306
21	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.47996853
22	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.46632322
23	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.45787194
24	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.37318720
25	REST_21632747_ChIP-Seq_MESCs_Mouse	1.36188819
26	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.35689365
27	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.34276051
28	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.31723907
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.31202217
30	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.30017683
31	KDM2B_26808549_Chip-Seq_REH_Human	1.28378155
32	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.28010429
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26844473
34	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.26059928
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.24588041
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.24588041
37	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24527706
38	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.23752091
39	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.23023854
40	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.22803150
41	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.19899590
42	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.19515644
43	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.18598856
44	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.15980746
45	P53_21459846_ChIP-Seq_SAOS-2_Human	1.13399253
46	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.09962532
47	* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.09581932
48	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.09402832
49	MYC_27129775_Chip-Seq_CORNEA_Mouse	1.09319136
50	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08805632
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.08805632
52	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	1.08153003
53	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.08078975
54	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.07085816
55	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05821494
56	GF1_26923725_Chip-Seq_HPCs_Mouse	1.05746379
57	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03881888
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02138300
59	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.01519807
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.01230756
61	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.99298783
62	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97956133
63	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.96735643
64	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96362474
65	SPI1_26923725_Chip-Seq_HPCs_Mouse	0.96077731
66	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.94456350
67	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.93916986
68	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.93710547
69	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.93519729
70	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92787709
71	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.92203791
72	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.91511648
73	SOX2_21211035_ChIP-Seq_LN229_Human	0.90295396
74	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.89267096
75	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.89262161
76	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.88758430
77	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.87631659
78	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.87171938
79	CTCF_20526341_ChIP-Seq_ESCs_Human	0.86744678
80	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.86685313
81	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.86553213
82	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.85923945
83	ERG_20517297_ChIP-Seq_VCAP_Human	0.84268050
84	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.83889794
85	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.83348034
86	CTCF_27219007_Chip-Seq_Bcells_Human	0.83010382
87	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.82377888
88	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.81567254
89	NFYB_21822215_ChIP-Seq_K562_Human	0.81302752
90	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.80950690
91	SOX11_22085726_ChIP-Seq_ESNs_Mouse	0.80864540
92	MYC_19829295_ChIP-Seq_ESCs_Human	0.80849503
93	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.80418552
94	TBL1_22424771_ChIP-Seq_293T_Human	0.80280171
95	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.80182280
96	PHF8_20622854_ChIP-Seq_HELA_Human	0.80020277
97	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.78966594
98	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.78898894
99	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.78659415
100	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.78064780

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	5.94156297
2	MP0001929_abnormal_gametogenesis	5.37271206
3	MP0008877_abnormal_DNA_methylation	4.81567240
4	MP0002210_abnormal_sex_determination	3.56690991
5	MP0002653_abnormal_ependyma_morphology	3.28241228
6	MP0002161_abnormal_fertility/fecundity	3.25391296
7	MP0001145_abnormal_male_reproductive	3.03582642
8	MP0000653_abnormal_sex_gland	2.61089686
9	MP0005670_abnormal_white_adipose	2.39108951
10	MP0005410_abnormal_fertilization	15.7689565
11	MP0005623_abnormal_meninges_morphology	1.76616441
12	MP0003646_muscle_fatigue	1.74764061
13	MP0002282_abnormal_trachea_morphology	1.68581408
14	MP0002160_abnormal_reproductive_system	1.49840586
15	MP0004233_abnormal_muscle_weight	1.33262714
16	MP0009046_muscle_twitch	1.12944966
17	MP0003115_abnormal_respiratory_system	1.08839275
18	MP0001984_abnormal_olfaction	1.05624466
19	MP0003011_delayed_dark_adaptation	0.97229975
20	MP0005423_abnormal_somatic_nervous	0.97063020
21	MP0001765_abnormal_ion_homeostasis	0.97008684
22	MP0010094_abnormal_chromosome_stability	0.92967240
23	MP0001986_abnormal_taste_sensitivity	0.91521061
24	MP0008995_early_reproductive_senescence	0.86610864
25	MP0005647_abnormal_sex_gland	0.81598350
26	MP0008058_abnormal_DNA_repair	0.80577323
27	MP0008961_abnormal_basal_metabolism	0.77836205
28	MP0009278_abnormal_bone_marrow	0.72542321
29	MP0003329_amyloid_beta_deposits	0.72430763
30	MP0000015_abnormal_ear_pigmentation	0.71954100
31	MP0005389_reproductive_system_phenotype	0.68081935
32	MP0000358_abnormal_cell_content/	0.66179109
33	MP0004808_abnormal_hematopoietic_stem	0.60843275
34	MP0005666_abnormal_adipose_tissue	0.59240877
35	MP0003878_abnormal_ear_physiology	0.56721325
36	MP0005377_hearing/vestibular/ear_phenot	0.56721325
37	MP0001545_abnormal_hematopoietic_system	0.55986087
38	MP0005397_hematopoietic_system_phenotyp	0.55986087
39	MP0002269_muscular_atrophy	0.51706498
40	MP0002971_abnormal_brown_adipose	0.51054929
41	MP0003111_abnormal_nucleus_morphology	0.48952851
42	MP0008057_abnormal_DNA_replication	0.48145020
43	MP0001324_abnormal_eye_pigmentation	0.47733778
44	MP0002928_abnormal_bile_duct	0.47370808
45	MP0000534_abnormal_ureter_morphology	0.47100546
46	MP0000569_abnormal_digit_pigmentation	0.46097777
47	MP0003045_fibrosis	0.45191652
48	MP0004130_abnormal_muscle_cell	0.42682084
49	MP0001293_anophthalmia	0.42543192
50	MP0002234_abnormal_pharynx_morphology	0.41912528
51	MP0004811_abnormal_neuron_physiology	0.41213941
52	MP0003699_abnormal_female_reproductive	0.40523888
53	MP0009115_abnormal_fat_cell	0.38925831
54	MP0005636_abnormal_mineral_homeostasis	0.38665970
55	MP0002295_abnormal_pulmonary_circulatio	0.37997812
56	MP0004036_abnormal_muscle_relaxation	0.37478499
57	MP0000604_amyloidosis	0.37383819
58	MP0003861_abnormal_nervous_system	0.36681788
59	MP0005551_abnormal_eye_electrophysiolog	0.35636657
60	MP0003942_abnormal_urinary_system	0.35539811
61	MP0002152_abnormal_brain_morphology	0.34659724
62	MP0004043_abnormal_pH_regulation	0.34155643
63	MP0003786_premature_aging	0.33392227
64	MP0001764_abnormal_homeostasis	0.32700303
65	MP0001730_embryonic_growth_arrest	0.32657563
66	MP0005253_abnormal_eye_physiology	0.31542664
67	MP0003631_nervous_system_phenotype	0.31178526
68	MP0010307_abnormal_tumor_latency	0.31064067
69	MP0003879_abnormal_hair_cell	0.30827608
70	MP0003633_abnormal_nervous_system	0.30583177
71	MP0005409_darkened_coat_color	0.30357330
72	MP0002139_abnormal_hepatobiliary_system	0.30010385
73	MP0005174_abnormal_tail_pigmentation	0.29591624
74	MP0003950_abnormal_plasma_membrane	0.28950438
75	MP0001661_extended_life_span	0.28773091
76	MP0008007_abnormal_cellular_replicative	0.27171866
77	MP0001119_abnormal_female_reproductive	0.26919992
78	MP0003948_abnormal_gas_homeostasis	0.26831169
79	MP0005365_abnormal_bile_salt	0.25751698
80	MP0006035_abnormal_mitochondrial_morpho	0.24902571
81	MP0005391_vision/eye_phenotype	0.24652113
82	MP0000313_abnormal_cell_death	0.23120935
83	MP0004270_analgesia	0.22732149
84	MP0008875_abnormal_xenobiotic_pharmacok	0.22544342
85	MP0003959_abnormal_lean_body	0.22056566
86	MP0003632_abnormal_nervous_system	0.21403810
87	MP0005375_adipose_tissue_phenotype	0.20617982
88	MP0005380_embryogenesis_phenotype	0.20066199
89	MP0001672_abnormal_embryogenesis/_devel	0.20066199
90	MP0002169_no_abnormal_phenotype	0.19845953
91	MP0001849_ear_inflammation	0.19750457
92	MP0002873_normal_phenotype	0.19644187
93	MP0003936_abnormal_reproductive_system	0.19159610
94	MP0002102_abnormal_ear_morphology	0.18969947
95	MP0002084_abnormal_developmental_patter	0.18706483
96	MP0002118_abnormal_lipid_homeostasis	0.18563389
97	MP0001697_abnormal_embryo_size	0.18191509
98	MP0005535_abnormal_body_temperature	0.17669832
99	MP0002572_abnormal_emotion/affect_behav	0.16965646
100	MP0008569_lethality_at_weaning	0.16940540

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory epithelium morphology (HP:0012253)	9.00412678
2	Abnormal respiratory motile cilium morphology (HP:0005938)	9.00412678
3	Abnormal respiratory motile cilium physiology (HP:0012261)	8.85067652
4	Rhinitis (HP:0012384)	7.63938957
5	Chronic bronchitis (HP:0004469)	7.24715921
6	Infertility (HP:0000789)	6.80449274
7	Nasal polyposis (HP:0100582)	6.60561345
8	Abnormal ciliary motility (HP:0012262)	6.42874990
9	Abnormality of the nasal mucosa (HP:0000433)	5.43515116
10	Bronchitis (HP:0012387)	4.74099952
11	Bronchiectasis (HP:0002110)	4.50421718
12	Male infertility (HP:0003251)	4.27967327
13	Nephronophthisis (HP:0000090)	4.17278013
14	Gonadotropin excess (HP:0000837)	3.57542436
15	Recurrent otitis media (HP:0000403)	3.43455456
16	Abnormal spermatogenesis (HP:0008669)	3.34830133
17	Impulsivity (HP:0100710)	3.31898341
18	Abnormality of the renal medulla (HP:0100957)	3.10111836
19	Recurrent bronchitis (HP:0002837)	3.07022639
20	Recurrent sinusitis (HP:0011108)	2.79380378
21	Spastic tetraparesis (HP:0001285)	2.78982882
22	Tubulointerstitial nephritis (HP:0001970)	2.47169311
23	Tubular atrophy (HP:0000092)	2.44055627
24	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.33932525
25	Abnormality of the lower motor neuron (HP:0002366)	2.33109247
26	Abnormality of midbrain morphology (HP:0002418)	2.29390009
27	Molar tooth sign on MRI (HP:0002419)	2.29390009
28	Heterotopia (HP:0002282)	2.26919421
29	Medial flaring of the eyebrow (HP:0010747)	2.23546248
30	Abnormal gallbladder physiology (HP:0012438)	2.20215577
31	Cholecystitis (HP:0001082)	2.20215577
32	Tubulointerstitial abnormality (HP:0001969)	2.13413280
33	Choroideremia (HP:0001139)	2.13222972
34	Azoospermia (HP:0000027)	2.12821034
35	Renovascular hypertension (HP:0100817)	2.00724942
36	Bell-shaped thorax (HP:0001591)	2.00368983
37	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	13.0713701
38	Dynein arm defect of respiratory motile cilia (HP:0012255)	12.8007991
39	Absent/shortened dynein arms (HP:0200106)	12.8007991
40	Postaxial foot polydactyly (HP:0001830)	1.98918393
41	Dyschromatopsia (HP:0007641)	1.94106976
42	Amyotrophic lateral sclerosis (HP:0007354)	1.89193160
43	Absent epiphyses (HP:0010577)	1.84031533
44	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.84031533
45	Stage 5 chronic kidney disease (HP:0003774)	1.81680269
46	Hemiparesis (HP:0001269)	1.81551752
47	Renal dysplasia (HP:0000110)	1.77107100
48	Tubulointerstitial fibrosis (HP:0005576)	1.73606528
49	Short ribs (HP:0000773)	1.73445758
50	Congenital hepatic fibrosis (HP:0002612)	1.69753616
51	Chronic sinusitis (HP:0011109)	1.69724571
52	Fibular hypoplasia (HP:0003038)	1.67958620
53	Sensory axonal neuropathy (HP:0003390)	1.66763575
54	Impaired proprioception (HP:0010831)	1.65273514
55	Elfin facies (HP:0004428)	1.63183903
56	Hyperacusis (HP:0010780)	1.62755703
57	Facial cleft (HP:0002006)	1.62738908
58	Oculomotor apraxia (HP:0000657)	1.60768901
59	Abnormal drinking behavior (HP:0030082)	1.60065796
60	Polydipsia (HP:0001959)	1.60065796
61	Neurofibrillary tangles (HP:0002185)	1.60029194
62	Hemorrhage of the eye (HP:0011885)	1.57437692
63	Retinal dysplasia (HP:0007973)	1.53391347
64	Overriding aorta (HP:0002623)	1.53140190
65	Decreased central vision (HP:0007663)	1.50931494
66	Postaxial hand polydactyly (HP:0001162)	1.50462873
67	Short thorax (HP:0010306)	1.50292010
68	Abnormality of the renal cortex (HP:0011035)	1.49596468
69	Deformed sella turcica (HP:0002681)	1.48346431
70	Aplasia/Hypoplasia of the lens (HP:0008063)	1.47659929
71	Absent frontal sinuses (HP:0002688)	1.46849268
72	Abnormality of dentin (HP:0010299)	1.45704456
73	Hyporeflexia of lower limbs (HP:0002600)	1.44896644
74	Microglossia (HP:0000171)	1.41563517
75	Lissencephaly (HP:0001339)	1.40818440
76	Abnormal biliary tract physiology (HP:0012439)	1.40232024
77	Bile duct proliferation (HP:0001408)	1.40232024
78	Cerebellar dysplasia (HP:0007033)	1.39471732
79	Pachygyria (HP:0001302)	1.38940615
80	Short femoral neck (HP:0100864)	1.38567474
81	J-shaped sella turcica (HP:0002680)	1.37360676
82	Median cleft lip (HP:0000161)	1.37028743
83	Insomnia (HP:0100785)	1.36113582
84	Type II lissencephaly (HP:0007260)	1.33514593
85	Loss of speech (HP:0002371)	1.33232714
86	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.32664263
87	Cerebral inclusion bodies (HP:0100314)	1.30543118
88	Gait imbalance (HP:0002141)	1.30483664
89	Abnormality of renal excretion (HP:0011036)	1.29425381
90	Renal duplication (HP:0000075)	1.29402486
91	Congenital primary aphakia (HP:0007707)	1.29162747
92	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.28199400
93	Abnormality of ocular smooth pursuit (HP:0000617)	1.27786036
94	Abnormality of permanent molar morphology (HP:0011071)	1.27711961
95	Abnormality of the dental root (HP:0006486)	1.27711961
96	Taurodontia (HP:0000679)	1.27711961
97	Polymicrogyria (HP:0002126)	1.27184544
98	Broad distal phalanx of finger (HP:0009836)	1.26709693
99	Flat cornea (HP:0007720)	1.26162233
100	Nephropathy (HP:0000112)	1.25953689

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK3	7.43626447
2	PDK4	7.43626447
3	PRKD3	7.33621193
4	TESK1	6.40424093
5	PDK2	4.77104952
6	ICK	4.70085226
7	PTK2B	2.01326673
8	WNK4	1.95954054
9	STK38	1.89166932
10	NEK2	1.87647138
11	STK39	1.87453920
12	PNCK	1.73642259
13	DYRK1B	1.51325413
14	MAPK15	1.07552328
15	PASK	1.07519902
16	STK3	0.96270647
17	TYRO3	0.88429813
18	BMPR1B	0.88085451
19	DYRK3	0.86881579
20	PDK1	0.86335104
21	WNK1	0.84609961
22	TESK2	0.80127358
23	CCNB1	0.71791395
24	TTK	0.59000023
25	RIPK4	0.54047181
26	CHEK2	0.51600643
27	PDPK1	0.46815771
28	IRAK1	0.45659742
29	MUSK	0.45396399
30	PINK1	0.43387306
31	CAMKK1	0.42457383
32	TAOK1	0.42260806
33	CAMK1G	0.42216678
34	NTRK2	0.39276513
35	CHEK1	0.39231111
36	PAK1	0.38680460
37	MTOR	0.38657040
38	LMTK2	0.35159222
39	CDC7	0.34845309
40	ATR	0.34326958
41	EEF2K	0.32628858
42	WEE1	0.31579555
43	MARK2	0.29313951
44	PAK2	0.27593994
45	YES1	0.27341592
46	IRAK2	0.25649365
47	ATM	0.25608076
48	PRKAA1	0.22587023
49	TRIB3	0.22176588
50	MAP2K6	0.22168704
51	MAPKAPK5	0.21714803
52	PAK4	0.17489268
53	PDGFRB	0.17236028
54	CDK12	0.17117505
55	PRKCG	0.16130279
56	RPS6KB1	0.14668866
57	MAP3K10	0.13982458
58	ZAP70	0.13823744
59	PLK1	0.13777352
60	STK11	0.11198292
61	STK38L	0.11128891
62	PAK6	0.10915101
63	EGFR	0.10044471
64	MAP3K9	0.08037379
65	NEK6	0.06011426
66	PRKD2	0.05423935
67	CLK1	0.05209311
68	PRKCZ	0.05118850
69	RPS6KA1	0.04946178
70	EPHB1	0.04926607
71	CDK6	0.04545509
72	PRKG1	0.03092656
73	BRSK2	0.02876746
74	CDK15	0.02458241
75	RIPK1	0.01903157
76	GSK3B	0.01888064
77	CSNK1D	0.01848584
78	PRKCQ	0.01718046
79	BUB1	0.01338531
80	PLK4	0.01138202
81	CDK2	0.01019161
82	CDK4	0.00944229
83	PRKACG	0.00509039
84	CDK1	0.00078446
85	CDK18	0.00056314
86	GRK1	-0.0383478
87	CSK	-0.0337593
88	MAP3K1	-0.0326127
89	AURKA	-0.0309906
90	PRKCB	-0.0293225
91	STK10	-0.0288967
92	BRSK1	-0.0265986
93	RPS6KA3	-0.0257173
94	CSNK2A1	-0.0214233
95	CAMK2A	-0.0196284
96	CDK14	-0.0190090
97	PRKACB	-0.0172765
98	CDK11A	-0.0136256
99	MAPK8	-0.0104399
100	MAPK10	-0.0097282

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin B6 metabolism_Homo sapiens_hsa00750	4.14361186
2	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	3.83282188
3	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.74082963
4	Pyruvate metabolism_Homo sapiens_hsa00620	3.59763616
5	Dorso-ventral axis formation_Homo sapiens_hsa04320	3.40399938
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.84107095
7	Propanoate metabolism_Homo sapiens_hsa00640	2.73010329
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.68298210
9	Glucagon signaling pathway_Homo sapiens_hsa04922	2.68175663
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.63493522
11	Pentose phosphate pathway_Homo sapiens_hsa00030	2.29139177
12	Glycerolipid metabolism_Homo sapiens_hsa00561	2.27258975
13	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	2.20705355
14	Basal transcription factors_Homo sapiens_hsa03022	2.13871151
15	PPAR signaling pathway_Homo sapiens_hsa03320	2.01665315
16	Oocyte meiosis_Homo sapiens_hsa04114	1.99659682
17	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.94843294
18	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.85488773
19	Amphetamine addiction_Homo sapiens_hsa05031	1.81923715
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.74335895
21	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.67157394
22	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.52952678
23	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.51985416
24	Fatty acid metabolism_Homo sapiens_hsa01212	1.44593125
25	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.42629551
26	Fatty acid degradation_Homo sapiens_hsa00071	1.42260848
27	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.40556513
28	Carbon metabolism_Homo sapiens_hsa01200	1.33020317
29	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.31658900
30	Fat digestion and absorption_Homo sapiens_hsa04975	1.30304999
31	Renin secretion_Homo sapiens_hsa04924	1.29894499
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.28439906
33	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.24361259
34	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.16029640
35	Long-term potentiation_Homo sapiens_hsa04720	1.10287029
36	Huntingtons disease_Homo sapiens_hsa05016	1.06602771
37	mRNA surveillance pathway_Homo sapiens_hsa03015	1.01929141
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.00433983
39	Antigen processing and presentation_Homo sapiens_hsa04612	0.95693001
40	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.92114435
41	ABC transporters_Homo sapiens_hsa02010	0.88304397
42	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.86764272
43	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.82691252
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82571903
45	Mineral absorption_Homo sapiens_hsa04978	0.80929897
46	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.79662867
47	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.79366070
48	Estrogen signaling pathway_Homo sapiens_hsa04915	0.78027087
49	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.76794658
50	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.75633514
51	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.74521777
52	Alcoholism_Homo sapiens_hsa05034	0.72045266
53	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71015833
54	* RNA transport_Homo sapiens_hsa03013	0.70813486
55	Purine metabolism_Homo sapiens_hsa00230	0.66707587
56	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.65190008
57	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.64291043
58	Endocytosis_Homo sapiens_hsa04144	0.61899084
59	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.61533031
60	AMPK signaling pathway_Homo sapiens_hsa04152	0.59150066
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58903736
62	Bile secretion_Homo sapiens_hsa04976	0.58483704
63	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.58309402
64	VEGF signaling pathway_Homo sapiens_hsa04370	0.58260469
65	Glutathione metabolism_Homo sapiens_hsa00480	0.58132779
66	Insulin secretion_Homo sapiens_hsa04911	0.57925757
67	Calcium signaling pathway_Homo sapiens_hsa04020	0.56883266
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.53747552
69	Taste transduction_Homo sapiens_hsa04742	0.49786908
70	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.49632800
71	Circadian entrainment_Homo sapiens_hsa04713	0.49055406
72	Legionellosis_Homo sapiens_hsa05134	0.48683593
73	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.47659539
74	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.47461652
75	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.44041341
76	Gastric acid secretion_Homo sapiens_hsa04971	0.43815178
77	Sulfur metabolism_Homo sapiens_hsa00920	0.41302201
78	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.40707489
79	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.39927738
80	Viral carcinogenesis_Homo sapiens_hsa05203	0.38282365
81	Cocaine addiction_Homo sapiens_hsa05030	0.37816610
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37205190
83	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36593413
84	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.36201596
85	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36162418
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.36100932
87	Basal cell carcinoma_Homo sapiens_hsa05217	0.30937372
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.30303051
89	Salivary secretion_Homo sapiens_hsa04970	0.28220079
90	Homologous recombination_Homo sapiens_hsa03440	0.27684877
91	Pancreatic secretion_Homo sapiens_hsa04972	0.26908125
92	Sphingolipid metabolism_Homo sapiens_hsa00600	0.26762282
93	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.26318239
94	Metabolic pathways_Homo sapiens_hsa01100	0.26258143
95	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.26176056
96	cAMP signaling pathway_Homo sapiens_hsa04024	0.25222118
97	Renin-angiotensin system_Homo sapiens_hsa04614	0.24160594
98	Peroxisome_Homo sapiens_hsa04146	0.23650771
99	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.20742693
100	Protein digestion and absorption_Homo sapiens_hsa04974	0.20462032

POM121L2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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