POM121L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.76434841
2acrosome assembly (GO:0001675)9.69822688
3epithelial cilium movement (GO:0003351)9.45163825
4regulation of cilium movement (GO:0003352)9.41589746
5spermatid development (GO:0007286)9.28098385
6plasma membrane fusion (GO:0045026)9.15384949
7cell wall macromolecule metabolic process (GO:0044036)8.73219064
8cell wall macromolecule catabolic process (GO:0016998)8.73219064
9reproduction (GO:0000003)8.45551945
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.25106984
11male meiosis (GO:0007140)8.03385151
12cilium movement (GO:0003341)7.86469086
13synaptonemal complex organization (GO:0070193)7.81174789
14synaptonemal complex assembly (GO:0007130)7.36493018
15single fertilization (GO:0007338)7.03143825
16DNA methylation involved in gamete generation (GO:0043046)6.63543092
17negative regulation of inclusion body assembly (GO:0090084)6.50636537
18sperm capacitation (GO:0048240)6.50488451
19microtubule depolymerization (GO:0007019)6.26054475
20spermatogenesis (GO:0007283)6.19806289
21male gamete generation (GO:0048232)6.17456204
22fertilization (GO:0009566)6.08782783
23male meiosis I (GO:0007141)5.79178455
24organic cation transport (GO:0015695)5.74321538
25gamete generation (GO:0007276)5.67161872
26regulation of microtubule-based movement (GO:0060632)5.56128334
27germ cell development (GO:0007281)5.32932693
28regulation of inclusion body assembly (GO:0090083)5.29237148
29chromosome organization involved in meiosis (GO:0070192)5.21708170
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.21455797
31left/right pattern formation (GO:0060972)5.14301292
32calcium ion-dependent exocytosis (GO:0017156)5.12700802
33ventricular system development (GO:0021591)5.06172967
34meiotic nuclear division (GO:0007126)5.03995260
35seminiferous tubule development (GO:0072520)4.90872148
36meiotic cell cycle (GO:0051321)4.80951978
37microtubule severing (GO:0051013)4.80221846
38cell recognition (GO:0008037)4.74596386
39meiosis I (GO:0007127)4.66144071
40gene silencing by RNA (GO:0031047)4.58823887
41multicellular organismal reproductive process (GO:0048609)4.46179255
42protein localization to cilium (GO:0061512)4.24615988
43protein polyglutamylation (GO:0018095)4.01425712
44carnitine transport (GO:0015879)3.90047005
45amino-acid betaine transport (GO:0015838)3.90047005
46carnitine transmembrane transport (GO:1902603)3.89834221
47regulation of spindle checkpoint (GO:0090231)3.66330560
48regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.61424275
49positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.61424275
50multicellular organismal development (GO:0007275)3.59689942
51chaperone-mediated protein complex assembly (GO:0051131)3.59647472
52glycerol ether metabolic process (GO:0006662)3.58561132
53genitalia morphogenesis (GO:0035112)3.47323971
54mitotic sister chromatid cohesion (GO:0007064)3.42975661
55polyol catabolic process (GO:0046174)3.41936342
56peptidyl-glutamic acid modification (GO:0018200)3.36545707
57chromosome condensation (GO:0030261)3.32886859
58ether metabolic process (GO:0018904)3.29897608
59DNA packaging (GO:0006323)3.29311546
60interferon-gamma secretion (GO:0072643)3.27910449
61positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.23968755
62regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.23968755
63synapsis (GO:0007129)3.23610490
64alditol metabolic process (GO:0019400)3.20019627
65negative regulation of organelle assembly (GO:1902116)3.19790470
66gene silencing (GO:0016458)3.19600808
67microtubule polymerization or depolymerization (GO:0031109)3.18155103
68meiotic cell cycle process (GO:1903046)3.16617220
69cilium morphogenesis (GO:0060271)3.12532070
70monoubiquitinated protein deubiquitination (GO:0035520)3.10965412
71regulation of meiosis I (GO:0060631)3.09031041
72intraciliary transport (GO:0042073)3.04033473
73protein refolding (GO:0042026)3.03248423
74microtubule-based movement (GO:0007018)3.01714721
75RNA localization (GO:0006403)2.95853889
76cilium organization (GO:0044782)2.95759460
77negative regulation of skeletal muscle tissue development (GO:0048642)2.89972635
78nucleosome disassembly (GO:0006337)2.89424757
79protein-DNA complex disassembly (GO:0032986)2.89424757
80axoneme assembly (GO:0035082)2.89209161
81spermatid nucleus differentiation (GO:0007289)2.86395799
82cilium assembly (GO:0042384)2.85171358
83positive regulation of mRNA 3-end processing (GO:0031442)2.76877481
84glycerol metabolic process (GO:0006071)2.75164514
85fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.74865129
86cellular response to arsenic-containing substance (GO:0071243)2.73760166
87quaternary ammonium group transport (GO:0015697)2.73445725
88RNA destabilization (GO:0050779)2.72036190
89nucleus organization (GO:0006997)2.71549227
90cellular component assembly involved in morphogenesis (GO:0010927)2.68141330
91sperm motility (GO:0030317)12.5608159
92fusion of sperm to egg plasma membrane (GO:0007342)12.0334875
93cilium or flagellum-dependent cell motility (GO:0001539)11.6520566
94axonemal dynein complex assembly (GO:0070286)11.5795163
95acrosome reaction (GO:0007340)11.5177085
96piRNA metabolic process (GO:0034587)11.0518956
97sperm-egg recognition (GO:0035036)10.9206462
98motile cilium assembly (GO:0044458)10.7179482
99multicellular organism reproduction (GO:0032504)10.3959957
100binding of sperm to zona pellucida (GO:0007339)10.1175160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.95467542
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.33637337
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.31555485
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.57283116
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.40603549
6* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.35125916
7GATA1_26923725_Chip-Seq_HPCs_Mouse2.19679093
8VDR_22108803_ChIP-Seq_LS180_Human2.17065814
9ELK4_26923725_Chip-Seq_MESODERM_Mouse2.02444239
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.7038794
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86385541
12EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.82209215
13ZNF274_21170338_ChIP-Seq_K562_Hela1.80908758
14FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73550129
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73174125
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.63389441
17* STAT1_17558387_ChIP-Seq_HELA_Human1.56778544
18WDR5_24793694_ChIP-Seq_LNCAP_Human1.55873497
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50920037
20TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.50497306
21MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47996853
22KAP1_22055183_ChIP-Seq_ESCs_Mouse1.46632322
23KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.45787194
24GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.37318720
25REST_21632747_ChIP-Seq_MESCs_Mouse1.36188819
26FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35689365
27GATA3_21867929_ChIP-Seq_CD8_Mouse1.34276051
28TAL1_26923725_Chip-Seq_HPCs_Mouse1.31723907
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31202217
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30017683
31KDM2B_26808549_Chip-Seq_REH_Human1.28378155
32SOX2_22085726_ChIP-Seq_NPCs_Mouse1.28010429
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26844473
34RUNX1_26923725_Chip-Seq_HPCs_Mouse1.26059928
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24588041
36CBP_20019798_ChIP-Seq_JUKART_Human1.24588041
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.24527706
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23752091
39LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.23023854
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22803150
41SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19899590
42SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.19515644
43PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18598856
44RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15980746
45P53_21459846_ChIP-Seq_SAOS-2_Human1.13399253
46RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09962532
47* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09581932
48GATA3_21867929_ChIP-Seq_TH1_Mouse1.09402832
49MYC_27129775_Chip-Seq_CORNEA_Mouse1.09319136
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08805632
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08805632
52PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08153003
53RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08078975
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07085816
55FLI1_21867929_ChIP-Seq_TH2_Mouse1.05821494
56GF1_26923725_Chip-Seq_HPCs_Mouse1.05746379
57SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03881888
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02138300
59RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01519807
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01230756
61EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99298783
62CRX_20693478_ChIP-Seq_RETINA_Mouse0.97956133
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96735643
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96362474
65SPI1_26923725_Chip-Seq_HPCs_Mouse0.96077731
66ELF1_20517297_ChIP-Seq_JURKAT_Human0.94456350
67RARA_24833708_ChIP-Seq_LIVER_Mouse0.93916986
68CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93710547
69CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93519729
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92787709
71NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.92203791
72YY1_22570637_ChIP-Seq_MALME-3M_Human0.91511648
73SOX2_21211035_ChIP-Seq_LN229_Human0.90295396
74ESET_19884257_ChIP-Seq_ESCs_Mouse0.89267096
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89262161
76LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88758430
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87631659
78CBX2_27304074_Chip-Seq_ESCs_Mouse0.87171938
79CTCF_20526341_ChIP-Seq_ESCs_Human0.86744678
80OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86685313
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86553213
82TET1_21451524_ChIP-Seq_MESCs_Mouse0.85923945
83ERG_20517297_ChIP-Seq_VCAP_Human0.84268050
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.83889794
85FLI1_21867929_ChIP-Seq_CD8_Mouse0.83348034
86CTCF_27219007_Chip-Seq_Bcells_Human0.83010382
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82377888
88CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81567254
89NFYB_21822215_ChIP-Seq_K562_Human0.81302752
90GF1B_26923725_Chip-Seq_HPCs_Mouse0.80950690
91SOX11_22085726_ChIP-Seq_ESNs_Mouse0.80864540
92MYC_19829295_ChIP-Seq_ESCs_Human0.80849503
93SMAD4_21741376_ChIP-Seq_EPCs_Human0.80418552
94TBL1_22424771_ChIP-Seq_293T_Human0.80280171
95GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80182280
96PHF8_20622854_ChIP-Seq_HELA_Human0.80020277
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.78966594
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78898894
99OCT4_18555785_Chip-Seq_ESCs_Mouse0.78659415
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.78064780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.94156297
2MP0001929_abnormal_gametogenesis5.37271206
3MP0008877_abnormal_DNA_methylation4.81567240
4MP0002210_abnormal_sex_determination3.56690991
5MP0002653_abnormal_ependyma_morphology3.28241228
6MP0002161_abnormal_fertility/fecundity3.25391296
7MP0001145_abnormal_male_reproductive3.03582642
8MP0000653_abnormal_sex_gland2.61089686
9MP0005670_abnormal_white_adipose2.39108951
10MP0005410_abnormal_fertilization15.7689565
11MP0005623_abnormal_meninges_morphology1.76616441
12MP0003646_muscle_fatigue1.74764061
13MP0002282_abnormal_trachea_morphology1.68581408
14MP0002160_abnormal_reproductive_system1.49840586
15MP0004233_abnormal_muscle_weight1.33262714
16MP0009046_muscle_twitch1.12944966
17MP0003115_abnormal_respiratory_system1.08839275
18MP0001984_abnormal_olfaction1.05624466
19MP0003011_delayed_dark_adaptation0.97229975
20MP0005423_abnormal_somatic_nervous0.97063020
21MP0001765_abnormal_ion_homeostasis0.97008684
22MP0010094_abnormal_chromosome_stability0.92967240
23MP0001986_abnormal_taste_sensitivity0.91521061
24MP0008995_early_reproductive_senescence0.86610864
25MP0005647_abnormal_sex_gland0.81598350
26MP0008058_abnormal_DNA_repair0.80577323
27MP0008961_abnormal_basal_metabolism0.77836205
28MP0009278_abnormal_bone_marrow0.72542321
29MP0003329_amyloid_beta_deposits0.72430763
30MP0000015_abnormal_ear_pigmentation0.71954100
31MP0005389_reproductive_system_phenotype0.68081935
32MP0000358_abnormal_cell_content/0.66179109
33MP0004808_abnormal_hematopoietic_stem0.60843275
34MP0005666_abnormal_adipose_tissue0.59240877
35MP0003878_abnormal_ear_physiology0.56721325
36MP0005377_hearing/vestibular/ear_phenot0.56721325
37MP0001545_abnormal_hematopoietic_system0.55986087
38MP0005397_hematopoietic_system_phenotyp0.55986087
39MP0002269_muscular_atrophy0.51706498
40MP0002971_abnormal_brown_adipose0.51054929
41MP0003111_abnormal_nucleus_morphology0.48952851
42MP0008057_abnormal_DNA_replication0.48145020
43MP0001324_abnormal_eye_pigmentation0.47733778
44MP0002928_abnormal_bile_duct0.47370808
45MP0000534_abnormal_ureter_morphology0.47100546
46MP0000569_abnormal_digit_pigmentation0.46097777
47MP0003045_fibrosis0.45191652
48MP0004130_abnormal_muscle_cell0.42682084
49MP0001293_anophthalmia0.42543192
50MP0002234_abnormal_pharynx_morphology0.41912528
51MP0004811_abnormal_neuron_physiology0.41213941
52MP0003699_abnormal_female_reproductive0.40523888
53MP0009115_abnormal_fat_cell0.38925831
54MP0005636_abnormal_mineral_homeostasis0.38665970
55MP0002295_abnormal_pulmonary_circulatio0.37997812
56MP0004036_abnormal_muscle_relaxation0.37478499
57MP0000604_amyloidosis0.37383819
58MP0003861_abnormal_nervous_system0.36681788
59MP0005551_abnormal_eye_electrophysiolog0.35636657
60MP0003942_abnormal_urinary_system0.35539811
61MP0002152_abnormal_brain_morphology0.34659724
62MP0004043_abnormal_pH_regulation0.34155643
63MP0003786_premature_aging0.33392227
64MP0001764_abnormal_homeostasis0.32700303
65MP0001730_embryonic_growth_arrest0.32657563
66MP0005253_abnormal_eye_physiology0.31542664
67MP0003631_nervous_system_phenotype0.31178526
68MP0010307_abnormal_tumor_latency0.31064067
69MP0003879_abnormal_hair_cell0.30827608
70MP0003633_abnormal_nervous_system0.30583177
71MP0005409_darkened_coat_color0.30357330
72MP0002139_abnormal_hepatobiliary_system0.30010385
73MP0005174_abnormal_tail_pigmentation0.29591624
74MP0003950_abnormal_plasma_membrane0.28950438
75MP0001661_extended_life_span0.28773091
76MP0008007_abnormal_cellular_replicative0.27171866
77MP0001119_abnormal_female_reproductive0.26919992
78MP0003948_abnormal_gas_homeostasis0.26831169
79MP0005365_abnormal_bile_salt0.25751698
80MP0006035_abnormal_mitochondrial_morpho0.24902571
81MP0005391_vision/eye_phenotype0.24652113
82MP0000313_abnormal_cell_death0.23120935
83MP0004270_analgesia0.22732149
84MP0008875_abnormal_xenobiotic_pharmacok0.22544342
85MP0003959_abnormal_lean_body0.22056566
86MP0003632_abnormal_nervous_system0.21403810
87MP0005375_adipose_tissue_phenotype0.20617982
88MP0005380_embryogenesis_phenotype0.20066199
89MP0001672_abnormal_embryogenesis/_devel0.20066199
90MP0002169_no_abnormal_phenotype0.19845953
91MP0001849_ear_inflammation0.19750457
92MP0002873_normal_phenotype0.19644187
93MP0003936_abnormal_reproductive_system0.19159610
94MP0002102_abnormal_ear_morphology0.18969947
95MP0002084_abnormal_developmental_patter0.18706483
96MP0002118_abnormal_lipid_homeostasis0.18563389
97MP0001697_abnormal_embryo_size0.18191509
98MP0005535_abnormal_body_temperature0.17669832
99MP0002572_abnormal_emotion/affect_behav0.16965646
100MP0008569_lethality_at_weaning0.16940540

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.00412678
2Abnormal respiratory motile cilium morphology (HP:0005938)9.00412678
3Abnormal respiratory motile cilium physiology (HP:0012261)8.85067652
4Rhinitis (HP:0012384)7.63938957
5Chronic bronchitis (HP:0004469)7.24715921
6Infertility (HP:0000789)6.80449274
7Nasal polyposis (HP:0100582)6.60561345
8Abnormal ciliary motility (HP:0012262)6.42874990
9Abnormality of the nasal mucosa (HP:0000433)5.43515116
10Bronchitis (HP:0012387)4.74099952
11Bronchiectasis (HP:0002110)4.50421718
12Male infertility (HP:0003251)4.27967327
13Nephronophthisis (HP:0000090)4.17278013
14Gonadotropin excess (HP:0000837)3.57542436
15Recurrent otitis media (HP:0000403)3.43455456
16Abnormal spermatogenesis (HP:0008669)3.34830133
17Impulsivity (HP:0100710)3.31898341
18Abnormality of the renal medulla (HP:0100957)3.10111836
19Recurrent bronchitis (HP:0002837)3.07022639
20Recurrent sinusitis (HP:0011108)2.79380378
21Spastic tetraparesis (HP:0001285)2.78982882
22Tubulointerstitial nephritis (HP:0001970)2.47169311
23Tubular atrophy (HP:0000092)2.44055627
24Hypoplasia of the capital femoral epiphysis (HP:0003090)2.33932525
25Abnormality of the lower motor neuron (HP:0002366)2.33109247
26Abnormality of midbrain morphology (HP:0002418)2.29390009
27Molar tooth sign on MRI (HP:0002419)2.29390009
28Heterotopia (HP:0002282)2.26919421
29Medial flaring of the eyebrow (HP:0010747)2.23546248
30Abnormal gallbladder physiology (HP:0012438)2.20215577
31Cholecystitis (HP:0001082)2.20215577
32Tubulointerstitial abnormality (HP:0001969)2.13413280
33Choroideremia (HP:0001139)2.13222972
34Azoospermia (HP:0000027)2.12821034
35Renovascular hypertension (HP:0100817)2.00724942
36Bell-shaped thorax (HP:0001591)2.00368983
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0713701
38Dynein arm defect of respiratory motile cilia (HP:0012255)12.8007991
39Absent/shortened dynein arms (HP:0200106)12.8007991
40Postaxial foot polydactyly (HP:0001830)1.98918393
41Dyschromatopsia (HP:0007641)1.94106976
42Amyotrophic lateral sclerosis (HP:0007354)1.89193160
43Absent epiphyses (HP:0010577)1.84031533
44Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.84031533
45Stage 5 chronic kidney disease (HP:0003774)1.81680269
46Hemiparesis (HP:0001269)1.81551752
47Renal dysplasia (HP:0000110)1.77107100
48Tubulointerstitial fibrosis (HP:0005576)1.73606528
49Short ribs (HP:0000773)1.73445758
50Congenital hepatic fibrosis (HP:0002612)1.69753616
51Chronic sinusitis (HP:0011109)1.69724571
52Fibular hypoplasia (HP:0003038)1.67958620
53Sensory axonal neuropathy (HP:0003390)1.66763575
54Impaired proprioception (HP:0010831)1.65273514
55Elfin facies (HP:0004428)1.63183903
56Hyperacusis (HP:0010780)1.62755703
57Facial cleft (HP:0002006)1.62738908
58Oculomotor apraxia (HP:0000657)1.60768901
59Abnormal drinking behavior (HP:0030082)1.60065796
60Polydipsia (HP:0001959)1.60065796
61Neurofibrillary tangles (HP:0002185)1.60029194
62Hemorrhage of the eye (HP:0011885)1.57437692
63Retinal dysplasia (HP:0007973)1.53391347
64Overriding aorta (HP:0002623)1.53140190
65Decreased central vision (HP:0007663)1.50931494
66Postaxial hand polydactyly (HP:0001162)1.50462873
67Short thorax (HP:0010306)1.50292010
68Abnormality of the renal cortex (HP:0011035)1.49596468
69Deformed sella turcica (HP:0002681)1.48346431
70Aplasia/Hypoplasia of the lens (HP:0008063)1.47659929
71Absent frontal sinuses (HP:0002688)1.46849268
72Abnormality of dentin (HP:0010299)1.45704456
73Hyporeflexia of lower limbs (HP:0002600)1.44896644
74Microglossia (HP:0000171)1.41563517
75Lissencephaly (HP:0001339)1.40818440
76Abnormal biliary tract physiology (HP:0012439)1.40232024
77Bile duct proliferation (HP:0001408)1.40232024
78Cerebellar dysplasia (HP:0007033)1.39471732
79Pachygyria (HP:0001302)1.38940615
80Short femoral neck (HP:0100864)1.38567474
81J-shaped sella turcica (HP:0002680)1.37360676
82Median cleft lip (HP:0000161)1.37028743
83Insomnia (HP:0100785)1.36113582
84Type II lissencephaly (HP:0007260)1.33514593
85Loss of speech (HP:0002371)1.33232714
86Decreased electroretinogram (ERG) amplitude (HP:0000654)1.32664263
87Cerebral inclusion bodies (HP:0100314)1.30543118
88Gait imbalance (HP:0002141)1.30483664
89Abnormality of renal excretion (HP:0011036)1.29425381
90Renal duplication (HP:0000075)1.29402486
91Congenital primary aphakia (HP:0007707)1.29162747
92Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.28199400
93Abnormality of ocular smooth pursuit (HP:0000617)1.27786036
94Abnormality of permanent molar morphology (HP:0011071)1.27711961
95Abnormality of the dental root (HP:0006486)1.27711961
96Taurodontia (HP:0000679)1.27711961
97Polymicrogyria (HP:0002126)1.27184544
98Broad distal phalanx of finger (HP:0009836)1.26709693
99Flat cornea (HP:0007720)1.26162233
100Nephropathy (HP:0000112)1.25953689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.43626447
2PDK47.43626447
3PRKD37.33621193
4TESK16.40424093
5PDK24.77104952
6ICK4.70085226
7PTK2B2.01326673
8WNK41.95954054
9STK381.89166932
10NEK21.87647138
11STK391.87453920
12PNCK1.73642259
13DYRK1B1.51325413
14MAPK151.07552328
15PASK1.07519902
16STK30.96270647
17TYRO30.88429813
18BMPR1B0.88085451
19DYRK30.86881579
20PDK10.86335104
21WNK10.84609961
22TESK20.80127358
23CCNB10.71791395
24TTK0.59000023
25RIPK40.54047181
26CHEK20.51600643
27PDPK10.46815771
28IRAK10.45659742
29MUSK0.45396399
30PINK10.43387306
31CAMKK10.42457383
32TAOK10.42260806
33CAMK1G0.42216678
34NTRK20.39276513
35CHEK10.39231111
36PAK10.38680460
37MTOR0.38657040
38LMTK20.35159222
39CDC70.34845309
40ATR0.34326958
41EEF2K0.32628858
42WEE10.31579555
43MARK20.29313951
44PAK20.27593994
45YES10.27341592
46IRAK20.25649365
47ATM0.25608076
48PRKAA10.22587023
49TRIB30.22176588
50MAP2K60.22168704
51MAPKAPK50.21714803
52PAK40.17489268
53PDGFRB0.17236028
54CDK120.17117505
55PRKCG0.16130279
56RPS6KB10.14668866
57MAP3K100.13982458
58ZAP700.13823744
59PLK10.13777352
60STK110.11198292
61STK38L0.11128891
62PAK60.10915101
63EGFR0.10044471
64MAP3K90.08037379
65NEK60.06011426
66PRKD20.05423935
67CLK10.05209311
68PRKCZ0.05118850
69RPS6KA10.04946178
70EPHB10.04926607
71CDK60.04545509
72PRKG10.03092656
73BRSK20.02876746
74CDK150.02458241
75RIPK10.01903157
76GSK3B0.01888064
77CSNK1D0.01848584
78PRKCQ0.01718046
79BUB10.01338531
80PLK40.01138202
81CDK20.01019161
82CDK40.00944229
83PRKACG0.00509039
84CDK10.00078446
85CDK180.00056314
86GRK1-0.0383478
87CSK-0.0337593
88MAP3K1-0.0326127
89AURKA-0.0309906
90PRKCB-0.0293225
91STK10-0.0288967
92BRSK1-0.0265986
93RPS6KA3-0.0257173
94CSNK2A1-0.0214233
95CAMK2A-0.0196284
96CDK14-0.0190090
97PRKACB-0.0172765
98CDK11A-0.0136256
99MAPK8-0.0104399
100MAPK10-0.0097282

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.14361186
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.83282188
3Fatty acid biosynthesis_Homo sapiens_hsa000613.74082963
4Pyruvate metabolism_Homo sapiens_hsa006203.59763616
5Dorso-ventral axis formation_Homo sapiens_hsa043203.40399938
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.84107095
7Propanoate metabolism_Homo sapiens_hsa006402.73010329
8Linoleic acid metabolism_Homo sapiens_hsa005912.68298210
9Glucagon signaling pathway_Homo sapiens_hsa049222.68175663
10Selenocompound metabolism_Homo sapiens_hsa004502.63493522
11Pentose phosphate pathway_Homo sapiens_hsa000302.29139177
12Glycerolipid metabolism_Homo sapiens_hsa005612.27258975
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.20705355
14Basal transcription factors_Homo sapiens_hsa030222.13871151
15PPAR signaling pathway_Homo sapiens_hsa033202.01665315
16Oocyte meiosis_Homo sapiens_hsa041141.99659682
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.94843294
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.85488773
19Amphetamine addiction_Homo sapiens_hsa050311.81923715
20Fanconi anemia pathway_Homo sapiens_hsa034601.74335895
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.67157394
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52952678
23Fructose and mannose metabolism_Homo sapiens_hsa000511.51985416
24Fatty acid metabolism_Homo sapiens_hsa012121.44593125
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.42629551
26Fatty acid degradation_Homo sapiens_hsa000711.42260848
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.40556513
28Carbon metabolism_Homo sapiens_hsa012001.33020317
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31658900
30Fat digestion and absorption_Homo sapiens_hsa049751.30304999
31Renin secretion_Homo sapiens_hsa049241.29894499
32Ether lipid metabolism_Homo sapiens_hsa005651.28439906
33Systemic lupus erythematosus_Homo sapiens_hsa053221.24361259
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16029640
35Long-term potentiation_Homo sapiens_hsa047201.10287029
36Huntingtons disease_Homo sapiens_hsa050161.06602771
37mRNA surveillance pathway_Homo sapiens_hsa030151.01929141
38Cardiac muscle contraction_Homo sapiens_hsa042601.00433983
39Antigen processing and presentation_Homo sapiens_hsa046120.95693001
40Biosynthesis of amino acids_Homo sapiens_hsa012300.92114435
41ABC transporters_Homo sapiens_hsa020100.88304397
42Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86764272
43Glycosaminoglycan degradation_Homo sapiens_hsa005310.82691252
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82571903
45Mineral absorption_Homo sapiens_hsa049780.80929897
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79662867
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.79366070
48Estrogen signaling pathway_Homo sapiens_hsa049150.78027087
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76794658
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75633514
51Hedgehog signaling pathway_Homo sapiens_hsa043400.74521777
52Alcoholism_Homo sapiens_hsa050340.72045266
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71015833
54* RNA transport_Homo sapiens_hsa030130.70813486
55Purine metabolism_Homo sapiens_hsa002300.66707587
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65190008
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64291043
58Endocytosis_Homo sapiens_hsa041440.61899084
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61533031
60AMPK signaling pathway_Homo sapiens_hsa041520.59150066
61Chemical carcinogenesis_Homo sapiens_hsa052040.58903736
62Bile secretion_Homo sapiens_hsa049760.58483704
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.58309402
64VEGF signaling pathway_Homo sapiens_hsa043700.58260469
65Glutathione metabolism_Homo sapiens_hsa004800.58132779
66Insulin secretion_Homo sapiens_hsa049110.57925757
67Calcium signaling pathway_Homo sapiens_hsa040200.56883266
68Arachidonic acid metabolism_Homo sapiens_hsa005900.53747552
69Taste transduction_Homo sapiens_hsa047420.49786908
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49632800
71Circadian entrainment_Homo sapiens_hsa047130.49055406
72Legionellosis_Homo sapiens_hsa051340.48683593
73Thyroid hormone synthesis_Homo sapiens_hsa049180.47659539
74Inositol phosphate metabolism_Homo sapiens_hsa005620.47461652
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44041341
76Gastric acid secretion_Homo sapiens_hsa049710.43815178
77Sulfur metabolism_Homo sapiens_hsa009200.41302201
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40707489
79Synaptic vesicle cycle_Homo sapiens_hsa047210.39927738
80Viral carcinogenesis_Homo sapiens_hsa052030.38282365
81Cocaine addiction_Homo sapiens_hsa050300.37816610
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37205190
83N-Glycan biosynthesis_Homo sapiens_hsa005100.36593413
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36201596
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.36162418
86Collecting duct acid secretion_Homo sapiens_hsa049660.36100932
87Basal cell carcinoma_Homo sapiens_hsa052170.30937372
88Glutamatergic synapse_Homo sapiens_hsa047240.30303051
89Salivary secretion_Homo sapiens_hsa049700.28220079
90Homologous recombination_Homo sapiens_hsa034400.27684877
91Pancreatic secretion_Homo sapiens_hsa049720.26908125
92Sphingolipid metabolism_Homo sapiens_hsa006000.26762282
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26318239
94Metabolic pathways_Homo sapiens_hsa011000.26258143
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26176056
96cAMP signaling pathway_Homo sapiens_hsa040240.25222118
97Renin-angiotensin system_Homo sapiens_hsa046140.24160594
98Peroxisome_Homo sapiens_hsa041460.23650771
99B cell receptor signaling pathway_Homo sapiens_hsa046620.20742693
100Protein digestion and absorption_Homo sapiens_hsa049740.20462032

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