POM121L4P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)8.64317139
2phosphate ion transmembrane transport (GO:0035435)8.10849460
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.23111225
4aminoglycoside antibiotic metabolic process (GO:0030647)6.65838685
5response to parathyroid hormone (GO:0071107)6.41132895
6negative regulation of cAMP-mediated signaling (GO:0043951)6.17526107
7regulation of RNA export from nucleus (GO:0046831)5.67520541
8energy homeostasis (GO:0097009)5.56518184
9tachykinin receptor signaling pathway (GO:0007217)5.49371716
10transmission of nerve impulse (GO:0019226)5.37969936
11response to mercury ion (GO:0046689)5.36968206
12hyperosmotic salinity response (GO:0042538)5.33299872
13positive regulation of uterine smooth muscle contraction (GO:0070474)5.32409166
14regulation of natural killer cell differentiation (GO:0032823)5.18485471
15regulation of hippo signaling (GO:0035330)5.18376151
16peristalsis (GO:0030432)5.03145445
17response to lead ion (GO:0010288)4.99379099
18detection of bacterium (GO:0016045)4.93478215
19phosphate ion homeostasis (GO:0055062)4.88064957
20trivalent inorganic anion homeostasis (GO:0072506)4.88064957
21regulation of catecholamine metabolic process (GO:0042069)4.57909108
22regulation of dopamine metabolic process (GO:0042053)4.57909108
23sensory perception of taste (GO:0050909)4.57827193
24positive regulation of action potential (GO:0045760)4.57097649
25histone H4-K12 acetylation (GO:0043983)4.50577404
26detection of other organism (GO:0098543)4.40647533
27regulation of nucleobase-containing compound transport (GO:0032239)4.38619016
28negative regulation of protein localization to cell surface (GO:2000009)4.34799391
29pentose metabolic process (GO:0019321)4.23920540
30negative regulation of heart rate (GO:0010459)4.22309381
31maternal behavior (GO:0042711)4.14695468
32regulation of uterine smooth muscle contraction (GO:0070472)4.14112679
33positive regulation of calcium ion import (GO:0090280)4.11078703
34regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.05966474
35regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.05966474
36behavioral response to nicotine (GO:0035095)3.95698891
37regulation of synaptic transmission, dopaminergic (GO:0032225)3.83691399
38response to magnesium ion (GO:0032026)3.79024906
39head development (GO:0060322)3.75257023
40positive regulation of heart rate (GO:0010460)3.71968874
41parental behavior (GO:0060746)3.65727233
42regulation of G0 to G1 transition (GO:0070316)3.64664333
43opioid receptor signaling pathway (GO:0038003)3.62981064
44folic acid metabolic process (GO:0046655)3.62357708
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.53492741
46response to vitamin A (GO:0033189)3.44785243
47epoxygenase P450 pathway (GO:0019373)3.40911192
48glycoside metabolic process (GO:0016137)3.40809371
49indole-containing compound metabolic process (GO:0042430)3.40505453
50nephron tubule morphogenesis (GO:0072078)3.39598441
51nephron epithelium morphogenesis (GO:0072088)3.39598441
52synapsis (GO:0007129)3.39386364
53positive regulation of systemic arterial blood pressure (GO:0003084)3.37222952
54tricarboxylic acid metabolic process (GO:0072350)3.34102161
55positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.31359387
56sleep (GO:0030431)3.29949620
57negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.21764932
58response to growth hormone (GO:0060416)3.19837849
59histone H4 acetylation (GO:0043967)3.19533331
60CTP biosynthetic process (GO:0006241)3.19479669
61CTP metabolic process (GO:0046036)3.19479669
62negative regulation of Rho protein signal transduction (GO:0035024)3.17499232
63chromatin silencing (GO:0006342)3.14135689
64embryonic digestive tract development (GO:0048566)3.13693021
65DNA methylation involved in gamete generation (GO:0043046)3.13205077
66regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.12362310
67regulation of feeding behavior (GO:0060259)3.11850800
68pyrimidine dimer repair (GO:0006290)3.11159722
69positive regulation of protein kinase C signaling (GO:0090037)3.11130491
70detection of light stimulus involved in visual perception (GO:0050908)3.08119152
71detection of light stimulus involved in sensory perception (GO:0050962)3.08119152
72dopamine transport (GO:0015872)3.03748975
73spermatid development (GO:0007286)3.02998094
74positive regulation of mitochondrial fission (GO:0090141)3.02758060
75negative regulation of JAK-STAT cascade (GO:0046426)3.00031678
76otic vesicle formation (GO:0030916)2.95316855
77renal tubule morphogenesis (GO:0061333)2.93520628
78pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.90906335
79regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.90874921
80photoreceptor cell maintenance (GO:0045494)2.90488806
81negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.86662096
82positive regulation of histone H3-K4 methylation (GO:0051571)2.86221373
83grooming behavior (GO:0007625)2.85630797
84sensory perception of sound (GO:0007605)2.85259326
85negative regulation of gene expression, epigenetic (GO:0045814)2.82698443
86response to thyroid hormone (GO:0097066)2.82602931
87positive regulation of protein export from nucleus (GO:0046827)2.81187079
88fat-soluble vitamin biosynthetic process (GO:0042362)2.78828269
89synaptic transmission, cholinergic (GO:0007271)2.78338581
90positive regulation of amino acid transport (GO:0051957)2.77059286
91cell redox homeostasis (GO:0045454)2.76938947
92maturation of 5.8S rRNA (GO:0000460)2.76128306
93rhodopsin mediated signaling pathway (GO:0016056)2.75851813
94sensory perception of mechanical stimulus (GO:0050954)2.75719520
95ribosomal large subunit biogenesis (GO:0042273)2.74166666
96pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.71497955
97methionine biosynthetic process (GO:0009086)2.71461219
98histone H2A acetylation (GO:0043968)12.6833282
99phosphate ion transport (GO:0006817)10.9839079
100peptidyl-tyrosine autophosphorylation (GO:0038083)10.1315936

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.43340701
2ZNF274_21170338_ChIP-Seq_K562_Hela3.07903532
3ZNF263_19887448_ChIP-Seq_K562_Human2.94567329
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.83422402
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.79287086
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.31257866
7FUS_26573619_Chip-Seq_HEK293_Human2.17421764
8E2F7_22180533_ChIP-Seq_HELA_Human2.13835776
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09381879
10GATA1_22025678_ChIP-Seq_K562_Human15.3410903
11CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99466063
12IGF1R_20145208_ChIP-Seq_DFB_Human1.82717200
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80418129
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.71696306
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71068139
16MYC_18940864_ChIP-ChIP_HL60_Human1.66122957
17UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65844922
18RXR_22108803_ChIP-Seq_LS180_Human1.55731557
19VDR_22108803_ChIP-Seq_LS180_Human1.54004037
20ER_23166858_ChIP-Seq_MCF-7_Human1.51962689
21GBX2_23144817_ChIP-Seq_PC3_Human1.41552856
22NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39601487
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38812071
24AUTS2_25519132_ChIP-Seq_293T-REX_Human1.38254746
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36959072
26DROSHA_22980978_ChIP-Seq_HELA_Human1.36472400
27TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23647898
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21732368
29STAT3_23295773_ChIP-Seq_U87_Human1.20773483
30KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18783846
31SMAD4_21741376_ChIP-Seq_EPCs_Human1.18103951
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15282512
33AR_25329375_ChIP-Seq_VCAP_Human1.15014473
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.13917464
35FOXH1_21741376_ChIP-Seq_ESCs_Human1.13772684
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13323780
37RUNX2_22187159_ChIP-Seq_PCA_Human1.13123194
38NCOR_22424771_ChIP-Seq_293T_Human1.12816605
39PRDM14_20953172_ChIP-Seq_ESCs_Human1.12171059
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.10009026
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09768035
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06815307
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.05706682
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04291413
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.04277200
46E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02173338
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01014166
48ESET_19884257_ChIP-Seq_ESCs_Mouse0.98746913
49REST_18959480_ChIP-ChIP_MESCs_Mouse0.97377876
50VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97302738
51STAT1_17558387_ChIP-Seq_HELA_Human0.97185870
52ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95038729
53PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91658213
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89935702
55GABP_17652178_ChIP-ChIP_JURKAT_Human0.89795408
56WDR5_24793694_ChIP-Seq_LNCAP_Human0.89543470
57PIAS1_25552417_ChIP-Seq_VCAP_Human0.88345485
58FLI1_27457419_Chip-Seq_LIVER_Mouse0.86334173
59NFE2_27457419_Chip-Seq_LIVER_Mouse0.85390559
60BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82831384
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.82142470
62ELK1_19687146_ChIP-ChIP_HELA_Human0.81396567
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81289457
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.80334958
65OCT4_20526341_ChIP-Seq_ESCs_Human0.80065670
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79182116
67EED_16625203_ChIP-ChIP_MESCs_Mouse0.79155941
68RAC3_21632823_ChIP-Seq_H3396_Human0.78629980
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78376925
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.78091008
71EZH2_18974828_ChIP-Seq_MESCs_Mouse0.77721529
72RNF2_18974828_ChIP-Seq_MESCs_Mouse0.77721529
73P300_18555785_Chip-Seq_ESCs_Mouse0.77233321
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.77187929
75SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.76005188
76TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76003024
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.75841514
78SOX2_19829295_ChIP-Seq_ESCs_Human0.75141375
79NANOG_19829295_ChIP-Seq_ESCs_Human0.75141375
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.74567474
81RUNX_20019798_ChIP-Seq_JUKART_Human0.74211264
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72555506
83SMAD4_21799915_ChIP-Seq_A2780_Human0.72530860
84GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.72407776
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.72222030
86TCF4_22108803_ChIP-Seq_LS180_Human0.71907387
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71611740
88STAT1_20625510_ChIP-Seq_HELA_Human0.70900596
89P300_19829295_ChIP-Seq_ESCs_Human0.70892458
90CMYC_18555785_Chip-Seq_ESCs_Mouse0.70785951
91E2F1_18555785_Chip-Seq_ESCs_Mouse0.70576314
92TP63_19390658_ChIP-ChIP_HaCaT_Human0.70242541
93* ERA_21632823_ChIP-Seq_H3396_Human0.69630358
94SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69182586
95SOX2_21211035_ChIP-Seq_LN229_Gbm0.68635861
96SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.68498997
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.68066570
98P53_21459846_ChIP-Seq_SAOS-2_Human0.68008047
99FOXA1_25329375_ChIP-Seq_VCAP_Human0.67658100
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.67658100

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.49809089
2MP0003878_abnormal_ear_physiology5.49809089
3MP0005397_hematopoietic_system_phenotyp4.42571999
4MP0001545_abnormal_hematopoietic_system4.42571999
5MP0005645_abnormal_hypothalamus_physiol3.48161641
6MP0004147_increased_porphyrin_level3.43310810
7MP0004510_myositis2.95346283
8MP0004808_abnormal_hematopoietic_stem2.55354899
9MP0002160_abnormal_reproductive_system2.52158004
10MP0002138_abnormal_hepatobiliary_system2.28413648
11MP0001485_abnormal_pinna_reflex2.22200318
12MP0004019_abnormal_vitamin_homeostasis2.22086991
13MP0005551_abnormal_eye_electrophysiolog2.14785098
14MP0006072_abnormal_retinal_apoptosis2.09797271
15MP0002332_abnormal_exercise_endurance2.05208923
16MP0008775_abnormal_heart_ventricle1.99898361
17MP0001486_abnormal_startle_reflex1.99668160
18MP0002822_catalepsy1.95089192
19MP0003045_fibrosis1.93109973
20MP0010386_abnormal_urinary_bladder1.89565662
21MP0005367_renal/urinary_system_phenotyp1.83941289
22MP0000516_abnormal_urinary_system1.83941289
23MP0002102_abnormal_ear_morphology1.83634993
24MP0001764_abnormal_homeostasis1.78661374
25MP0005319_abnormal_enzyme/_coenzyme1.76313530
26MP0004215_abnormal_myocardial_fiber1.75748335
27MP0003136_yellow_coat_color1.73316011
28MP0002735_abnormal_chemical_nociception1.72345901
29MP0003763_abnormal_thymus_physiology1.68134451
30MP0000538_abnormal_urinary_bladder1.66559119
31MP0005410_abnormal_fertilization1.62493915
32MP0005389_reproductive_system_phenotype1.58573854
33MP0009333_abnormal_splenocyte_physiolog1.56956908
34MP0006276_abnormal_autonomic_nervous1.51914226
35MP0000427_abnormal_hair_cycle1.51658051
36MP0008877_abnormal_DNA_methylation1.49398096
37MP0009278_abnormal_bone_marrow1.43930128
38MP0003283_abnormal_digestive_organ1.42713099
39MP0000383_abnormal_hair_follicle1.42130450
40MP0004085_abnormal_heartbeat1.38053934
41MP0001501_abnormal_sleep_pattern1.35123495
42MP0009765_abnormal_xenobiotic_induced1.31814732
43MP0005220_abnormal_exocrine_pancreas1.31233428
44MP0006035_abnormal_mitochondrial_morpho1.30506167
45MP0005647_abnormal_sex_gland1.30322470
46MP0002733_abnormal_thermal_nociception1.24576772
47MP0006292_abnormal_olfactory_placode1.23927471
48MP0009672_abnormal_birth_weight1.20503088
49MP0006138_congestive_heart_failure1.16441018
50MP0005253_abnormal_eye_physiology1.13762485
51MP0000678_abnormal_parathyroid_gland1.12933567
52MP0000749_muscle_degeneration1.10799535
53MP0004133_heterotaxia1.10778810
54MP0001348_abnormal_lacrimal_gland1.09165525
55MP0005195_abnormal_posterior_eye1.08762209
56MP0004782_abnormal_surfactant_physiolog1.06152411
57MP0010678_abnormal_skin_adnexa1.04624664
58MP0003880_abnormal_central_pattern0.93320572
59MP0001963_abnormal_hearing_physiology0.92941944
60MP0003698_abnormal_male_reproductive0.92669408
61MP0002184_abnormal_innervation0.90144285
62MP0010094_abnormal_chromosome_stability0.86376538
63MP0003252_abnormal_bile_duct0.85637495
64MP0002837_dystrophic_cardiac_calcinosis0.83728811
65MP0001970_abnormal_pain_threshold0.82748932
66MP0009046_muscle_twitch0.82337745
67MP0010368_abnormal_lymphatic_system0.81873336
68MP0003959_abnormal_lean_body0.81429493
69MP0004858_abnormal_nervous_system0.81212048
70MP0001929_abnormal_gametogenesis0.78588936
71MP0001765_abnormal_ion_homeostasis0.78020556
72MP0001905_abnormal_dopamine_level0.77024722
73MP0002168_other_aberrant_phenotype0.75648050
74MP0003635_abnormal_synaptic_transmissio0.74566767
75MP0000631_abnormal_neuroendocrine_gland0.72507856
76MP0000604_amyloidosis0.72343598
77MP0009745_abnormal_behavioral_response0.71544380
78MP0000230_abnormal_systemic_arterial0.71015382
79MP0005360_urolithiasis0.70820518
80MP0003137_abnormal_impulse_conducting0.68895465
81MP0008058_abnormal_DNA_repair0.68118423
82MP0005636_abnormal_mineral_homeostasis0.68037107
83MP0001984_abnormal_olfaction0.67580669
84MP0000049_abnormal_middle_ear0.67436217
85MP0001919_abnormal_reproductive_system0.65841230
86MP0001986_abnormal_taste_sensitivity0.64492322
87MP0002229_neurodegeneration0.63883900
88MP0000026_abnormal_inner_ear0.62656823
89MP0002752_abnormal_somatic_nervous0.62642938
90MP0002063_abnormal_learning/memory/cond0.62481079
91MP0004145_abnormal_muscle_electrophysio0.62401216
92MP0003786_premature_aging0.60898984
93MP0000465_gastrointestinal_hemorrhage0.59524934
94MP0001756_abnormal_urination0.58960031
95MP0001664_abnormal_digestion0.58022892
96MP0002098_abnormal_vibrissa_morphology0.57964370
97MP0000751_myopathy0.57641330
98MP0000372_irregular_coat_pigmentation0.55708621
99MP0004885_abnormal_endolymph0.55638410
100MP0001145_abnormal_male_reproductive0.55634283

Predicted human phenotypes

RankGene SetZ-score
1Proximal tubulopathy (HP:0000114)7.85933412
2Severe visual impairment (HP:0001141)7.18201866
3Pendular nystagmus (HP:0012043)6.98271069
4Popliteal pterygium (HP:0009756)5.21406020
5Congenital stationary night blindness (HP:0007642)4.94752485
6True hermaphroditism (HP:0010459)4.84215300
7Pancreatic fibrosis (HP:0100732)4.61999044
8Pancreatic cysts (HP:0001737)4.17489898
9Absent rod-and cone-mediated responses on ERG (HP:0007688)4.16134047
10Abnormality of urine glucose concentration (HP:0011016)4.01084547
11Glycosuria (HP:0003076)4.01084547
12Myokymia (HP:0002411)3.99547122
13Abnormality of placental membranes (HP:0011409)3.75388106
14Amniotic constriction ring (HP:0009775)3.75388106
15Cystic liver disease (HP:0006706)3.64519000
16Parakeratosis (HP:0001036)3.61988090
17Attenuation of retinal blood vessels (HP:0007843)3.51654481
18Abolished electroretinogram (ERG) (HP:0000550)3.49677508
19Abnormal rod and cone electroretinograms (HP:0008323)3.30473079
20Acute lymphatic leukemia (HP:0006721)3.26246446
21Keratoconus (HP:0000563)3.13817739
22Increased corneal curvature (HP:0100692)3.13817739
23Optic nerve hypoplasia (HP:0000609)3.06764449
24Genetic anticipation (HP:0003743)2.88593456
25Renal cortical cysts (HP:0000803)2.87051033
26Sclerocornea (HP:0000647)2.86912027
27Aplasia/Hypoplasia of the tongue (HP:0010295)2.81039265
28Abnormality of macular pigmentation (HP:0008002)2.79143350
29Abnormality of the anterior horn cell (HP:0006802)2.77985175
30Degeneration of anterior horn cells (HP:0002398)2.77985175
31Hyperphosphaturia (HP:0003109)2.77094942
32Long clavicles (HP:0000890)2.76907387
33Fetal akinesia sequence (HP:0001989)2.74574225
34Bile duct proliferation (HP:0001408)2.74156740
35Abnormal biliary tract physiology (HP:0012439)2.74156740
36Hyperkalemia (HP:0002153)2.70711958
37Male pseudohermaphroditism (HP:0000037)2.68683059
38Hypoglycemic coma (HP:0001325)2.66163617
39Abnormality of DNA repair (HP:0003254)2.63808757
40Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.62713214
41Aplasia of the musculature (HP:0100854)2.62172621
42Poikiloderma (HP:0001029)2.60939049
43Congenital sensorineural hearing impairment (HP:0008527)2.55694067
44Furrowed tongue (HP:0000221)2.53579108
45Anencephaly (HP:0002323)2.50787085
46Decreased central vision (HP:0007663)2.48796811
47Postaxial foot polydactyly (HP:0001830)2.39800368
48Abnormal number of erythroid precursors (HP:0012131)2.39734536
49Malignant hyperthermia (HP:0002047)2.38506362
50Cystic hygroma (HP:0000476)2.38387207
51Neonatal respiratory distress (HP:0002643)2.38019493
52Diaphragmatic weakness (HP:0009113)2.30318475
53Abnormality of the labia majora (HP:0012881)2.29012299
54Congenital hepatic fibrosis (HP:0002612)2.28807351
55Abnormality of cells of the erythroid lineage (HP:0012130)2.22143504
56J-shaped sella turcica (HP:0002680)2.18969081
57Rib fusion (HP:0000902)2.17666442
58Abnormality of the renal collecting system (HP:0004742)2.17390151
59Chorioretinal atrophy (HP:0000533)2.15993959
60Abnormal urine phosphate concentration (HP:0012599)2.13965957
61Hypercalciuria (HP:0002150)2.12382940
62Progressive cerebellar ataxia (HP:0002073)2.08293694
63Nausea (HP:0002018)2.06286781
64Rickets (HP:0002748)2.05641354
65Type 2 muscle fiber atrophy (HP:0003554)2.04185388
66Bony spicule pigmentary retinopathy (HP:0007737)2.03809690
67Stenosis of the external auditory canal (HP:0000402)2.03406639
68Nonprogressive disorder (HP:0003680)2.02597190
69Abnormality of the heme biosynthetic pathway (HP:0010472)2.02131210
70Generalized aminoaciduria (HP:0002909)10.4528827
71Agnosia (HP:0010524)1.96826738
72Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.96422371
73Decreased circulating renin level (HP:0003351)1.94168453
74Abnormality of homocysteine metabolism (HP:0010919)1.94157598
75Homocystinuria (HP:0002156)1.94157598
763-Methylglutaconic aciduria (HP:0003535)1.92588509
77Abnormality of the renal cortex (HP:0011035)1.89964551
78Nephronophthisis (HP:0000090)1.88015186
79Abnormality of chloride homeostasis (HP:0011422)1.86258344
80Preaxial hand polydactyly (HP:0001177)1.85097198
81Chronic bronchitis (HP:0004469)1.81976950
82Clumsiness (HP:0002312)1.77930058
83Resting tremor (HP:0002322)1.76391300
84Recurrent corneal erosions (HP:0000495)1.75997950
85Macular degeneration (HP:0000608)1.75316533
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74252286
87Occipital encephalocele (HP:0002085)1.67768284
88Abnormality of the renal medulla (HP:0100957)1.67386272
89Squamous cell carcinoma (HP:0002860)1.65480824
90Neonatal death (HP:0003811)1.64958220
91Chronic hepatic failure (HP:0100626)1.64596338
92Facial diplegia (HP:0001349)1.64058770
93Abnormal auditory evoked potentials (HP:0006958)1.63586579
94Pterygium (HP:0001059)1.61577823
95Muscle fiber atrophy (HP:0100295)1.60144133
96Posterior subcapsular cataract (HP:0007787)1.58221976
97Sloping forehead (HP:0000340)1.55389918
98Hyperactive renin-angiotensin system (HP:0000841)1.55108145
99Deformed sella turcica (HP:0002681)1.51140438
100Postaxial hand polydactyly (HP:0001162)1.50973823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK196.12509165
2FRK5.67534738
3ADRBK23.89485629
4TXK3.76557026
5GRK72.64623159
6PINK12.62161380
7FGFR22.54529870
8AURKA2.36245402
9MAP4K12.30786518
10ZAK1.94597213
11MOS1.74013197
12TGFBR21.60424760
13TRIM281.59037089
14BMPR1B1.56010120
15TAOK31.46911399
16NTRK31.45032223
17BCKDK1.39027347
18JAK31.33615893
19TLK11.31517831
20GRK51.27885030
21WNK31.18496425
22CDK121.15559216
23CHEK21.12866753
24PLK41.10534308
25DAPK21.07239619
26TNK21.07054467
27RPS6KA41.04376401
28CSNK1G31.04090139
29BTK1.01332336
30VRK10.99398565
31INSRR0.95775100
32MAP4K20.93187707
33SYK0.91985959
34TYRO30.88556763
35TIE10.87082920
36CSNK1G10.85948925
37PRKACB0.85713679
38GRK10.85321973
39PRKG20.85291065
40MAP3K70.84629225
41PRKCD0.82664724
42MAP2K60.82088773
43MINK10.81724886
44RPS6KA50.81326570
45MAP2K70.80938055
46MAPK130.80902970
47CSNK1A1L0.80672254
48MYLK0.76838238
49CHEK10.76312624
50MAPK150.76096858
51PRKCG0.75056456
52OBSCN0.72495452
53PRKD30.72191563
54MARK30.69750511
55DYRK1B0.69595878
56KIT0.69117650
57CSNK1G20.67475273
58TESK10.63293378
59KDR0.62567437
60CDK80.62103737
61LYN0.61327459
62NTRK20.60614942
63CSNK1A10.59852606
64LCK0.55613637
65MATK0.54052415
66PRKACA0.53245313
67TGFBR10.52454340
68ACVR1B0.52399194
69DDR20.52019318
70PRKD20.51932597
71PRKCH0.51925024
72MAPK80.51004382
73STK110.50970296
74DYRK20.50922670
75ADRBK10.50714649
76EGFR0.50427477
77PKN10.50296092
78BCR0.49617993
79PLK30.47770767
80DAPK30.47284302
81STK100.46185289
82MAPK100.45751964
83CDC70.44410400
84INSR0.44333488
85ZAP700.42101852
86PTK2B0.42037620
87CSNK2A10.42003957
88OXSR10.41666473
89RPS6KB10.40568415
90CASK0.40547313
91PDGFRA0.37674265
92MAPK40.37598518
93WEE10.37486821
94CSNK2A20.37229835
95PRKACG0.35520827
96CSNK1E0.34166234
97JAK20.33313838
98CDK11A0.31608802
99PLK10.31261358
100MUSK0.30988549

Predicted pathways (KEGG)

RankGene SetZ-score
1Renin-angiotensin system_Homo sapiens_hsa046145.87335585
2Phototransduction_Homo sapiens_hsa047444.47708118
3Pentose and glucuronate interconversions_Homo sapiens_hsa000402.99858969
4Taste transduction_Homo sapiens_hsa047422.80494736
5Butanoate metabolism_Homo sapiens_hsa006502.61319542
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.39177580
7Nicotine addiction_Homo sapiens_hsa050332.37705446
8Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.30774548
9Homologous recombination_Homo sapiens_hsa034402.29694138
10Steroid hormone biosynthesis_Homo sapiens_hsa001402.28904379
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.28661426
12Selenocompound metabolism_Homo sapiens_hsa004502.19577047
13Retinol metabolism_Homo sapiens_hsa008302.18874097
14Chemical carcinogenesis_Homo sapiens_hsa052041.99954702
15Drug metabolism - other enzymes_Homo sapiens_hsa009831.88989020
16Starch and sucrose metabolism_Homo sapiens_hsa005001.78089380
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76347985
18Ribosome_Homo sapiens_hsa030101.67368556
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.66925938
20One carbon pool by folate_Homo sapiens_hsa006701.65404958
21Vitamin digestion and absorption_Homo sapiens_hsa049771.60830067
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52605519
23African trypanosomiasis_Homo sapiens_hsa051431.50286605
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47679159
25DNA replication_Homo sapiens_hsa030301.47593070
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40364784
27Fanconi anemia pathway_Homo sapiens_hsa034601.27854762
28Morphine addiction_Homo sapiens_hsa050321.25983849
29Sulfur relay system_Homo sapiens_hsa041221.23739725
30Cocaine addiction_Homo sapiens_hsa050301.20618702
31Caffeine metabolism_Homo sapiens_hsa002321.16499408
32Nitrogen metabolism_Homo sapiens_hsa009101.13831197
33Pyrimidine metabolism_Homo sapiens_hsa002401.04312282
34Gap junction_Homo sapiens_hsa045401.02696081
35Calcium signaling pathway_Homo sapiens_hsa040201.02037688
36Olfactory transduction_Homo sapiens_hsa047400.98571961
37Mismatch repair_Homo sapiens_hsa034300.96988886
38Intestinal immune network for IgA production_Homo sapiens_hsa046720.93363392
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.87183482
40Linoleic acid metabolism_Homo sapiens_hsa005910.85312761
41Amphetamine addiction_Homo sapiens_hsa050310.83647436
42Circadian entrainment_Homo sapiens_hsa047130.81506328
43Renin secretion_Homo sapiens_hsa049240.79626642
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78767464
45GABAergic synapse_Homo sapiens_hsa047270.76815023
46Fatty acid degradation_Homo sapiens_hsa000710.76368209
47Salivary secretion_Homo sapiens_hsa049700.74290973
48Systemic lupus erythematosus_Homo sapiens_hsa053220.74162573
49Asthma_Homo sapiens_hsa053100.73406429
50Purine metabolism_Homo sapiens_hsa002300.69071903
51Fatty acid metabolism_Homo sapiens_hsa012120.69059060
52Nucleotide excision repair_Homo sapiens_hsa034200.68519865
53Cardiac muscle contraction_Homo sapiens_hsa042600.67216614
54Protein digestion and absorption_Homo sapiens_hsa049740.65833134
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65638923
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64792778
57cAMP signaling pathway_Homo sapiens_hsa040240.64037116
58Alcoholism_Homo sapiens_hsa050340.62783226
59ABC transporters_Homo sapiens_hsa020100.59554802
60Sulfur metabolism_Homo sapiens_hsa009200.57153107
61Hedgehog signaling pathway_Homo sapiens_hsa043400.56995542
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56550394
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.54702367
64Glutamatergic synapse_Homo sapiens_hsa047240.54371404
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54198381
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.53076829
67Fatty acid biosynthesis_Homo sapiens_hsa000610.49941997
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49664943
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.48189142
70Spliceosome_Homo sapiens_hsa030400.46844474
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46345614
72Primary immunodeficiency_Homo sapiens_hsa053400.45708314
73Glutathione metabolism_Homo sapiens_hsa004800.43725756
74Ether lipid metabolism_Homo sapiens_hsa005650.43640209
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43596243
76Arachidonic acid metabolism_Homo sapiens_hsa005900.42690913
77Propanoate metabolism_Homo sapiens_hsa006400.41297301
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40202592
79Proteasome_Homo sapiens_hsa030500.39960311
80Graft-versus-host disease_Homo sapiens_hsa053320.39850392
81Gastric acid secretion_Homo sapiens_hsa049710.37212083
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36316824
83Parkinsons disease_Homo sapiens_hsa050120.35041747
84Peroxisome_Homo sapiens_hsa041460.34835411
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34431021
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.29711669
87Serotonergic synapse_Homo sapiens_hsa047260.28509063
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28444859
89PPAR signaling pathway_Homo sapiens_hsa033200.27956693
90Antigen processing and presentation_Homo sapiens_hsa046120.27878842
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27877327
92Autoimmune thyroid disease_Homo sapiens_hsa053200.27557820
93Metabolic pathways_Homo sapiens_hsa011000.26320783
94Base excision repair_Homo sapiens_hsa034100.25274925
95Arginine and proline metabolism_Homo sapiens_hsa003300.24334859
96Allograft rejection_Homo sapiens_hsa053300.22842539
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22412738
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.20964710
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.18526242
100Pertussis_Homo sapiens_hsa051330.18294161

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