ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome reaction (GO:0007340)	9.54601409
2	response to pheromone (GO:0019236)	9.41385027
3	sperm motility (GO:0030317)	9.25395310
4	fusion of sperm to egg plasma membrane (GO:0007342)	8.29049668
5	chromosome condensation (GO:0030261)	7.41692394
6	sperm capacitation (GO:0048240)	7.28614110
7	DNA packaging (GO:0006323)	7.26538651
8	protein targeting to Golgi (GO:0000042)	6.96187280
9	establishment of protein localization to Golgi (GO:0072600)	6.86967357
10	spermatid development (GO:0007286)	6.75471432
11	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.51991019
12	rRNA methylation (GO:0031167)	6.34916183
13	single strand break repair (GO:0000012)	6.34715685
14	plasma membrane fusion (GO:0045026)	6.16654053
15	microtubule depolymerization (GO:0007019)	6.10368371
16	cellular ketone body metabolic process (GO:0046950)	5.85389574
17	sperm-egg recognition (GO:0035036)	5.61277520
18	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	5.57197551
19	regulation of G0 to G1 transition (GO:0070316)	5.39141436
20	spermatid nucleus differentiation (GO:0007289)	5.38391372
21	protein localization to Golgi apparatus (GO:0034067)	5.35423764
22	negative regulation of inclusion body assembly (GO:0090084)	5.31780493
23	multicellular organism reproduction (GO:0032504)	5.25978210
24	calcium ion-dependent exocytosis (GO:0017156)	5.16337797
25	ketone body metabolic process (GO:1902224)	5.12634980
26	rRNA modification (GO:0000154)	5.10868596
27	regulation of ARF GTPase activity (GO:0032312)	5.10353341
28	binding of sperm to zona pellucida (GO:0007339)	5.04528242
29	reproduction (GO:0000003)	5.02118989
30	spermatogenesis (GO:0007283)	4.94955320
31	microtubule polymerization or depolymerization (GO:0031109)	4.94885297
32	sexual reproduction (GO:0019953)	4.94601010
33	male gamete generation (GO:0048232)	4.93351875
34	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.92961133
35	positive regulation of Rab GTPase activity (GO:0032851)	4.83568128
36	regulation of Rab GTPase activity (GO:0032313)	4.83568128
37	cell-cell recognition (GO:0009988)	4.79282691
38	protein polyglutamylation (GO:0018095)	4.69067312
39	RNA destabilization (GO:0050779)	4.62951335
40	chromatin silencing (GO:0006342)	4.55704282
41	phosphatidylethanolamine metabolic process (GO:0046337)	4.52735029
42	maintenance of gastrointestinal epithelium (GO:0030277)	4.51255174
43	cell wall macromolecule catabolic process (GO:0016998)	4.47859653
44	gamete generation (GO:0007276)	4.45848851
45	regulation of cilium movement (GO:0003352)	4.31244268
46	response to vitamin A (GO:0033189)	4.21663834
47	coenzyme catabolic process (GO:0009109)	4.19294381
48	cell wall macromolecule metabolic process (GO:0044036)	4.07137369
49	axonemal dynein complex assembly (GO:0070286)	3.98802772
50	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.90890910
51	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.90890910
52	regulation of inclusion body assembly (GO:0090083)	3.87091720
53	negative regulation of Rho protein signal transduction (GO:0035024)	3.87029468
54	motile cilium assembly (GO:0044458)	3.85391215
55	germ cell development (GO:0007281)	3.79827609
56	microtubule severing (GO:0051013)	3.75482386
57	cilium or flagellum-dependent cell motility (GO:0001539)	3.67843712
58	single fertilization (GO:0007338)	3.66477989
59	regulation of transcription involved in cell fate commitment (GO:0060850)	3.64332423
60	multicellular organismal reproductive process (GO:0048609)	3.57792729
61	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.52307660
62	actin filament capping (GO:0051693)	3.30132714
63	O-glycan processing (GO:0016266)	3.28205071
64	Golgi to endosome transport (GO:0006895)	3.28119973
65	histone H3-K9 demethylation (GO:0033169)	3.27956384
66	NAD biosynthetic process (GO:0009435)	3.27735725
67	epithelial structure maintenance (GO:0010669)	3.27442533
68	regulation of mesoderm development (GO:2000380)	3.23668300
69	nephron epithelium morphogenesis (GO:0072088)	3.21309648
70	nephron tubule morphogenesis (GO:0072078)	3.21309648
71	histone H3 deacetylation (GO:0070932)	3.15127304
72	negative regulation of gene expression, epigenetic (GO:0045814)	3.10372468
73	lactate metabolic process (GO:0006089)	3.09686436
74	nucleus organization (GO:0006997)	3.09095391
75	somite rostral/caudal axis specification (GO:0032525)	3.08379768
76	estrogen biosynthetic process (GO:0006703)	3.04973218
77	intra-Golgi vesicle-mediated transport (GO:0006891)	3.04877853
78	glycerol ether metabolic process (GO:0006662)	2.99547580
79	cell differentiation involved in metanephros development (GO:0072202)	2.98149189
80	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.91188677
81	epithelial cell fate commitment (GO:0072148)	2.88817751
82	nucleosome disassembly (GO:0006337)	2.87925825
83	protein-DNA complex disassembly (GO:0032986)	2.87925825
84	regulation of somitogenesis (GO:0014807)	2.84757778
85	peptidyl-threonine dephosphorylation (GO:0035970)	2.82283240
86	centriole replication (GO:0007099)	2.81583658
87	coronary vasculature morphogenesis (GO:0060977)	2.81488724
88	fertilization (GO:0009566)	2.80874874
89	receptor recycling (GO:0001881)	2.74912311
90	DNA conformation change (GO:0071103)	2.74585905
91	ether metabolic process (GO:0018904)	2.74474252
92	negative regulation of actin filament depolymerization (GO:0030835)	2.74347767
93	genitalia morphogenesis (GO:0035112)	2.73377716
94	protein depolymerization (GO:0051261)	2.72951395
95	regulation of microtubule-based movement (GO:0060632)	2.72858622
96	peptidyl-proline hydroxylation (GO:0019511)	2.72826853
97	inner cell mass cell proliferation (GO:0001833)	2.72193515
98	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.65557264
99	cell migration involved in gastrulation (GO:0042074)	2.65293355
100	regulation of acrosome reaction (GO:0060046)	2.62860651

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.42946717
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.28903997
3	DROSHA_22980978_ChIP-Seq_HELA_Human	3.16636959
4	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.63471439
5	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.41958544
6	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.24260658
7	WDR5_24793694_ChIP-Seq_LNCAP_Human	2.15370542
8	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.09615669
9	CBP_20019798_ChIP-Seq_JUKART_Human	2.09615669
10	ERA_21632823_ChIP-Seq_H3396_Human	2.09273583
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.07808751
12	CTCF_27219007_Chip-Seq_Bcells_Human	2.05574258
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.98695526
14	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.95026597
15	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.92412242
16	SMC4_20622854_ChIP-Seq_HELA_Human	1.84657348
17	BCL6_27268052_Chip-Seq_Bcells_Human	1.84363627
18	E2F1_20622854_ChIP-Seq_HELA_Human	1.84222077
19	P68_20966046_ChIP-Seq_HELA_Human	1.76625071
20	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.75208319
21	PHF8_20622854_ChIP-Seq_HELA_Human	1.70408880
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.70338653
23	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.70338653
24	BCOR_27268052_Chip-Seq_Bcells_Human	1.69895780
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.66866680
26	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.65517206
27	ZNF274_21170338_ChIP-Seq_K562_Hela	1.64716688
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62876657
29	RAC3_21632823_ChIP-Seq_H3396_Human	1.62733860
30	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.62393220
31	NANOG_20526341_ChIP-Seq_ESCs_Human	1.61996282
32	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.61775824
33	OCT4_20526341_ChIP-Seq_ESCs_Human	1.59811111
34	TP63_22573176_ChIP-Seq_HFKS_Human	1.57195626
35	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.55308477
36	TAF2_19829295_ChIP-Seq_ESCs_Human	1.55097913
37	MYC_19829295_ChIP-Seq_ESCs_Human	1.52746816
38	CTCF_20526341_ChIP-Seq_ESCs_Human	1.52388666
39	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.49847469
40	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.48536302
41	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.48388367
42	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.46108500
43	FUS_26573619_Chip-Seq_HEK293_Human	1.43838873
44	P300_27268052_Chip-Seq_Bcells_Human	1.43554386
45	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.40009638
46	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.35104933
47	LXR_22292898_ChIP-Seq_THP-1_Human	1.34280485
48	AR_25329375_ChIP-Seq_VCAP_Human	1.32801696
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.31918706
50	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.31309605
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30962339
52	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.28954065
53	P53_21459846_ChIP-Seq_SAOS-2_Human	1.28399915
54	SA1_27219007_Chip-Seq_Bcells_Human	1.27570223
55	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.27003046
56	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.26808563
57	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.26776105
58	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25728273
59	HOXB7_26014856_ChIP-Seq_BT474_Human	1.25569561
60	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.22760866
61	TP53_18474530_ChIP-ChIP_U2OS_Human	1.22353215
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21479640
63	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.18935924
64	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16808858
65	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.16227763
66	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.15682303
67	NFYA_21822215_ChIP-Seq_K562_Human	1.15180108
68	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.15109873
69	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.13204694
70	NFYB_21822215_ChIP-Seq_K562_Human	1.12658802
71	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.12571035
72	RUNX_20019798_ChIP-Seq_JUKART_Human	1.11785054
73	RBPJ_21746931_ChIP-Seq_IB4_Human	1.11766953
74	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.11497275
75	OCT4_19829295_ChIP-Seq_ESCs_Human	1.11139685
76	SMRT_27268052_Chip-Seq_Bcells_Human	1.08838854
77	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.08814758
78	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08713202
79	TBL1_22424771_ChIP-Seq_293T_Human	1.08158102
80	TAF15_26573619_Chip-Seq_HEK293_Human	1.07129042
81	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.06100211
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05084538
83	ETV1_20927104_ChIP-Seq_GIST48_Human	1.04750777
84	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.04452940
85	GBX2_23144817_ChIP-Seq_PC3_Human	1.03810930
86	KLF5_25053715_ChIP-Seq_YYC3_Human	1.01547779
87	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99145563
88	PHF8_20622853_ChIP-Seq_HELA_Human	0.98630838
89	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96502235
90	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96413161
91	REST_21632747_ChIP-Seq_MESCs_Mouse	0.96277525
92	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.95359356
93	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93787303
94	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.93240252
95	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.92246223
96	P300_19829295_ChIP-Seq_ESCs_Human	0.91879924
97	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.91587704
98	STAT3_23295773_ChIP-Seq_U87_Human	0.91437862
99	CEBPB_22108803_ChIP-Seq_LS180_Human	0.90267908
100	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.89947534

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	9.48435920
2	MP0008995_early_reproductive_senescence	4.44533281
3	MP0003878_abnormal_ear_physiology	4.22674219
4	MP0005377_hearing/vestibular/ear_phenot	4.22674219
5	MP0003698_abnormal_male_reproductive	3.49803625
6	MP0001348_abnormal_lacrimal_gland	3.24279886
7	MP0001929_abnormal_gametogenesis	2.86973722
8	MP0005670_abnormal_white_adipose	2.72362801
9	MP0003890_abnormal_embryonic-extraembry	2.24000806
10	MP0008961_abnormal_basal_metabolism	2.22059702
11	MP0001765_abnormal_ion_homeostasis	2.17471519
12	MP0002822_catalepsy	2.13238670
13	MP0002254_reproductive_system_inflammat	2.06706067
14	MP0001485_abnormal_pinna_reflex	1.98155382
15	MP0002234_abnormal_pharynx_morphology	1.94841286
16	MP0005187_abnormal_penis_morphology	1.93095301
17	MP0009053_abnormal_anal_canal	1.92964382
18	MP0001501_abnormal_sleep_pattern	1.92074834
19	MP0002161_abnormal_fertility/fecundity	1.91382339
20	MP0000566_synostosis	1.79737991
21	MP0000465_gastrointestinal_hemorrhage	1.77931505
22	MP0003879_abnormal_hair_cell	1.77903838
23	MP0005379_endocrine/exocrine_gland_phen	1.75432172
24	MP0001666_abnormal_nutrient_absorption	1.67481861
25	MP0003646_muscle_fatigue	1.60508882
26	MP0005083_abnormal_biliary_tract	1.56398642
27	MP0005310_abnormal_salivary_gland	1.53916031
28	MP0002127_abnormal_cardiovascular_syste	1.45889797
29	MP0001963_abnormal_hearing_physiology	1.38081800
30	MP0004742_abnormal_vestibular_system	1.35676912
31	MP0000579_abnormal_nail_morphology	1.30311891
32	MP0000467_abnormal_esophagus_morphology	1.28793448
33	MP0003786_premature_aging	1.28006443
34	MP0002138_abnormal_hepatobiliary_system	1.27614550
35	MP0003718_maternal_effect	1.27150401
36	MP0003011_delayed_dark_adaptation	1.24026307
37	MP0000026_abnormal_inner_ear	1.22389054
38	MP0005551_abnormal_eye_electrophysiolog	1.21896459
39	MP0002210_abnormal_sex_determination	1.16458330
40	MP0000678_abnormal_parathyroid_gland	1.16245950
41	MP0002249_abnormal_larynx_morphology	1.15792437
42	MP0003172_abnormal_lysosome_physiology	1.15058997
43	MP0001968_abnormal_touch/_nociception	1.13766654
44	MP0001486_abnormal_startle_reflex	1.09795319
45	MP0005423_abnormal_somatic_nervous	1.08911639
46	MP0005636_abnormal_mineral_homeostasis	1.08231313
47	MP0001873_stomach_inflammation	1.06840534
48	MP0002132_abnormal_respiratory_system	1.05634206
49	MP0004043_abnormal_pH_regulation	1.05259884
50	MP0003880_abnormal_central_pattern	0.99587165
51	MP0000653_abnormal_sex_gland	0.99217346
52	MP0002735_abnormal_chemical_nociception	0.98450551
53	MP0008004_abnormal_stomach_pH	0.97178652
54	MP0002229_neurodegeneration	0.97119489
55	MP0000470_abnormal_stomach_morphology	0.96075534
56	MP0004270_analgesia	0.95836589
57	MP0001661_extended_life_span	0.95140176
58	MP0001145_abnormal_male_reproductive	0.94738702
59	MP0000003_abnormal_adipose_tissue	0.93742314
60	MP0005257_abnormal_intraocular_pressure	0.92087777
61	MP0000647_abnormal_sebaceous_gland	0.92082425
62	MP0005253_abnormal_eye_physiology	0.89264528
63	MP0004233_abnormal_muscle_weight	0.89070335
64	MP0000613_abnormal_salivary_gland	0.86815922
65	MP0001502_abnormal_circadian_rhythm	0.83941970
66	MP0000230_abnormal_systemic_arterial	0.83903047
67	MP0000955_abnormal_spinal_cord	0.83034910
68	MP0003091_abnormal_cell_migration	0.81309727
69	MP0004510_myositis	0.81283707
70	MP0002067_abnormal_sensory_capabilities	0.79251869
71	MP0002557_abnormal_social/conspecific_i	0.78811106
72	MP0000049_abnormal_middle_ear	0.78029421
73	MP0002060_abnormal_skin_morphology	0.76892925
74	MP0004264_abnormal_extraembryonic_tissu	0.75811604
75	MP0001664_abnormal_digestion	0.73278198
76	MP0004019_abnormal_vitamin_homeostasis	0.70284418
77	MP0002733_abnormal_thermal_nociception	0.68951104
78	MP0003137_abnormal_impulse_conducting	0.68809959
79	MP0004085_abnormal_heartbeat	0.68507131
80	MP0001986_abnormal_taste_sensitivity	0.64809301
81	MP0005365_abnormal_bile_salt	0.63407731
82	MP0009384_cardiac_valve_regurgitation	0.61850197
83	MP0009780_abnormal_chondrocyte_physiolo	0.60937191
84	MP0003119_abnormal_digestive_system	0.60870854
85	MP0002693_abnormal_pancreas_physiology	0.57293649
86	MP0003283_abnormal_digestive_organ	0.56445503
87	MP0000015_abnormal_ear_pigmentation	0.54820206
88	MP0004133_heterotaxia	0.54722962
89	MP0002638_abnormal_pupillary_reflex	0.54337152
90	MP0002184_abnormal_innervation	0.54189358
91	MP0002837_dystrophic_cardiac_calcinosis	0.53900482
92	MP0009046_muscle_twitch	0.52608282
93	MP0005395_other_phenotype	0.52483176
94	MP0000569_abnormal_digit_pigmentation	0.51698936
95	MP0000538_abnormal_urinary_bladder	0.50822038
96	MP0002098_abnormal_vibrissa_morphology	0.48768201
97	MP0005367_renal/urinary_system_phenotyp	0.48635572
98	MP0000516_abnormal_urinary_system	0.48635572
99	MP0002572_abnormal_emotion/affect_behav	0.47385971
100	MP0004484_altered_response_of	0.47100787

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital malformation of the right heart (HP:0011723)	5.83243439
2	Double outlet right ventricle (HP:0001719)	5.83243439
3	Severe visual impairment (HP:0001141)	5.79025311
4	Intestinal atresia (HP:0011100)	5.60069993
5	Abnormality of the parathyroid morphology (HP:0011766)	5.16428464
6	Anal stenosis (HP:0002025)	4.80592569
7	Nuclear cataract (HP:0100018)	4.79898083
8	Attenuation of retinal blood vessels (HP:0007843)	4.56903267
9	Bony spicule pigmentary retinopathy (HP:0007737)	4.50473347
10	Oligodactyly (hands) (HP:0001180)	4.48266117
11	Esophageal atresia (HP:0002032)	4.02278146
12	Enlarged epiphyses (HP:0010580)	3.84878556
13	Hyperkalemia (HP:0002153)	3.64871764
14	Aqueductal stenosis (HP:0002410)	3.44292019
15	Abnormal rod and cone electroretinograms (HP:0008323)	3.43996360
16	Chin dimple (HP:0010751)	3.43812773
17	Down-sloping shoulders (HP:0200021)	3.43034386
18	Labial hypoplasia (HP:0000066)	3.38256353
19	Mixed hearing impairment (HP:0000410)	3.35786468
20	Popliteal pterygium (HP:0009756)	3.18732061
21	Gastrointestinal atresia (HP:0002589)	3.14641574
22	Hypoplastic female external genitalia (HP:0012815)	3.10876297
23	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.05965884
24	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.01227560
25	Abnormality of the distal phalanges of the toes (HP:0010182)	3.00862656
26	Oligodactyly (HP:0012165)	2.91538110
27	Progressive cerebellar ataxia (HP:0002073)	2.88846517
28	Hypoplastic ischia (HP:0003175)	2.74816829
29	Deep palmar crease (HP:0006191)	2.72095468
30	Facial shape deformation (HP:0011334)	2.71011638
31	Potter facies (HP:0002009)	2.71011638
32	Impulsivity (HP:0100710)	2.69831755
33	Abnormality of the labia (HP:0000058)	2.59210143
34	Asymmetric septal hypertrophy (HP:0001670)	2.56804359
35	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.56084246
36	Aplasia involving forearm bones (HP:0009822)	2.43771435
37	Absent forearm bone (HP:0003953)	2.43771435
38	Abnormality of the ischium (HP:0003174)	2.40295644
39	Absent radius (HP:0003974)	2.40235708
40	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.38038501
41	Chromsome breakage (HP:0040012)	2.37724875
42	Stridor (HP:0010307)	2.37309794
43	Unilateral renal agenesis (HP:0000122)	2.36512313
44	Abnormality of the aortic arch (HP:0012303)	2.36428208
45	Malnutrition (HP:0004395)	2.35228998
46	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.33515460
47	Bell-shaped thorax (HP:0001591)	2.31889707
48	Pendular nystagmus (HP:0012043)	2.30925603
49	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.28828464
50	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.22784348
51	Absent/shortened dynein arms (HP:0200106)	2.22784348
52	Male infertility (HP:0003251)	2.22409964
53	Generalized aminoaciduria (HP:0002909)	2.21983738
54	Cupped ear (HP:0000378)	2.21070872
55	Infertility (HP:0000789)	2.20352931
56	Tubulointerstitial nephritis (HP:0001970)	2.19168964
57	Abnormality of the labia majora (HP:0012881)	2.15656900
58	Duplicated collecting system (HP:0000081)	2.15071210
59	Hypoplastic labia majora (HP:0000059)	2.13685227
60	Abnormality of potassium homeostasis (HP:0011042)	2.09961231
61	Abnormality of chloride homeostasis (HP:0011422)	2.08053157
62	Abnormality of macular pigmentation (HP:0008002)	2.07905381
63	Palpebral edema (HP:0100540)	2.06974881
64	Hypophosphatemic rickets (HP:0004912)	2.06272047
65	Short thumb (HP:0009778)	2.05769856
66	Hypoplasia of the thymus (HP:0000778)	2.04843211
67	Progressive sensorineural hearing impairment (HP:0000408)	2.04798902
68	Broad face (HP:0000283)	2.03555598
69	Abnormality of the costochondral junction (HP:0000919)	2.01185868
70	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.98295479
71	Widely patent fontanelles and sutures (HP:0004492)	1.97626602
72	Resting tremor (HP:0002322)	1.96893332
73	Abnormality of the femoral head (HP:0003368)	1.96452307
74	Abnormality of the duodenum (HP:0002246)	1.96418427
75	Chronic hepatic failure (HP:0100626)	1.94290632
76	Distal upper limb amyotrophy (HP:0007149)	1.94028288
77	Upper limb amyotrophy (HP:0009129)	1.94028288
78	Laryngomalacia (HP:0001601)	1.91789885
79	Zonular cataract (HP:0010920)	1.91224403
80	Congenital sensorineural hearing impairment (HP:0008527)	1.90752657
81	Abdominal situs inversus (HP:0003363)	1.89978989
82	Abnormality of abdominal situs (HP:0011620)	1.89978989
83	Horseshoe kidney (HP:0000085)	1.89533034
84	Pili torti (HP:0003777)	1.85598033
85	Hand muscle atrophy (HP:0009130)	1.81922644
86	Anencephaly (HP:0002323)	1.80308517
87	Abnormality of the nasal septum (HP:0000419)	1.79690386
88	Abnormality of the renal collecting system (HP:0004742)	1.78544851
89	Bilateral sensorineural hearing impairment (HP:0008619)	1.77345501
90	Delayed epiphyseal ossification (HP:0002663)	1.76044321
91	Absent thumb (HP:0009777)	1.75551290
92	Urethral obstruction (HP:0000796)	1.74828448
93	Obsessive-compulsive behavior (HP:0000722)	1.74508498
94	Renovascular hypertension (HP:0100817)	1.72758163
95	Decreased circulating renin level (HP:0003351)	1.71462757
96	Abnormality of the preputium (HP:0100587)	1.71194694
97	Neonatal respiratory distress (HP:0002643)	1.68788972
98	Flattened epiphyses (HP:0003071)	1.68532298
99	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.68377931
100	Cleft eyelid (HP:0000625)	1.66651517

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST1R	4.86543620
2	WNK4	4.37438541
3	INSRR	4.04072557
4	TESK1	3.77098887
5	PLK4	3.76025850
6	MAP3K3	3.59042975
7	MAP3K2	3.41733566
8	DDR2	3.32315820
9	MAP4K2	2.94108999
10	CDK12	2.82180537
11	NME1	2.66185545
12	WNK1	2.64381995
13	BRD4	2.29390753
14	FRK	2.10476090
15	STK38	1.92782413
16	CAMK1G	1.72610427
17	MAP3K9	1.68370422
18	MAPK15	1.58216290
19	ERBB4	1.47554571
20	PLK2	1.47480959
21	PKN2	1.32609988
22	MET	1.29330064
23	CAMK1D	1.24189638
24	SIK2	1.18006387
25	ICK	1.17249050
26	MUSK	1.04133434
27	PDK1	0.98194914
28	PDPK1	0.97938134
29	MST4	0.97818936
30	ZAK	0.93732006
31	TNK2	0.93672889
32	TLK1	0.91852395
33	MAP2K6	0.91383383
34	PRKAA2	0.89119529
35	MAP2K2	0.88989620
36	MAP3K7	0.84445558
37	RPS6KA2	0.82339155
38	STK39	0.80134444
39	PINK1	0.79774263
40	PRKG2	0.79211333
41	CDK7	0.76800110
42	BMPR1B	0.76563598
43	GRK1	0.76148246
44	ERBB2	0.74452691
45	FGFR2	0.73742717
46	NEK6	0.72924649
47	EPHA3	0.70633072
48	GRK6	0.67845437
49	DYRK1B	0.67746187
50	MTOR	0.64961657
51	RPS6KA1	0.63620625
52	PRKAA1	0.61028539
53	PTK2B	0.59480910
54	FLT3	0.58087224
55	PIK3CG	0.56729700
56	PNCK	0.55915361
57	BLK	0.55256607
58	CHUK	0.55243529
59	TRPM7	0.51893989
60	RPS6KC1	0.51097438
61	RPS6KL1	0.51097438
62	BCKDK	0.50526138
63	RPS6KA6	0.49431852
64	PASK	0.47697750
65	SGK1	0.46894992
66	CHEK1	0.45674088
67	MARK2	0.45372268
68	SGK223	0.43668671
69	SGK494	0.43668671
70	ARAF	0.43553739
71	MAPK11	0.43325073
72	MAPK1	0.42752301
73	PRKD3	0.41527296
74	GSK3B	0.41336597
75	PHKG2	0.40898732
76	PHKG1	0.40898732
77	TAOK3	0.40104230
78	PRKG1	0.39744043
79	MAP3K4	0.39183686
80	ACVR1B	0.39113341
81	LMTK2	0.36476359
82	ROCK1	0.36397908
83	NEK2	0.35753488
84	STK38L	0.34387807
85	MAPK13	0.33438814
86	AKT3	0.32939880
87	PTK6	0.32415374
88	CAMK1	0.32191220
89	MAP3K13	0.32166117
90	SGK2	0.31790621
91	CDK2	0.30831844
92	AKT1	0.30696313
93	CSNK1D	0.30473920
94	CDK1	0.30436528
95	DAPK2	0.28435188
96	MAPK8	0.28176882
97	SGK3	0.27447580
98	PIM2	0.26743476
99	PIM1	0.25403142
100	CDC42BPA	0.24390203

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	6.18941108
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.40883347
3	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	3.17373837
4	Olfactory transduction_Homo sapiens_hsa04740	2.63932743
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.42789521
6	Butanoate metabolism_Homo sapiens_hsa00650	2.37605756
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.15188318
8	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.88150558
9	Salivary secretion_Homo sapiens_hsa04970	1.79312679
10	Type II diabetes mellitus_Homo sapiens_hsa04930	1.79130366
11	Phototransduction_Homo sapiens_hsa04744	1.79072294
12	ABC transporters_Homo sapiens_hsa02010	1.74851288
13	Fatty acid metabolism_Homo sapiens_hsa01212	1.74225706
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.66132064
15	Circadian entrainment_Homo sapiens_hsa04713	1.65585103
16	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.65430509
17	Taste transduction_Homo sapiens_hsa04742	1.57164027
18	Circadian rhythm_Homo sapiens_hsa04710	1.50191024
19	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.49674766
20	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.48258836
21	Oocyte meiosis_Homo sapiens_hsa04114	1.47208201
22	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.41600928
23	Insulin secretion_Homo sapiens_hsa04911	1.35248110
24	Lysine degradation_Homo sapiens_hsa00310	1.34765584
25	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.33374364
26	Protein digestion and absorption_Homo sapiens_hsa04974	1.31708228
27	Arginine and proline metabolism_Homo sapiens_hsa00330	1.30819973
28	Type I diabetes mellitus_Homo sapiens_hsa04940	1.24540543
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.22201580
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.18376456
31	Fatty acid degradation_Homo sapiens_hsa00071	1.16678017
32	Peroxisome_Homo sapiens_hsa04146	1.16574534
33	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.15762400
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.12710862
35	Phenylalanine metabolism_Homo sapiens_hsa00360	1.09919810
36	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.07520960
37	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.03112881
38	Calcium signaling pathway_Homo sapiens_hsa04020	0.98633420
39	Arginine biosynthesis_Homo sapiens_hsa00220	0.97761155
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.97689729
41	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.93516032
42	Gastric acid secretion_Homo sapiens_hsa04971	0.93492208
43	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.91968743
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.89684374
45	cAMP signaling pathway_Homo sapiens_hsa04024	0.89013822
46	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.87265343
47	Endocytosis_Homo sapiens_hsa04144	0.86655295
48	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.84561103
49	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.83603563
50	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.81862094
51	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.80194642
52	Retinol metabolism_Homo sapiens_hsa00830	0.77365222
53	Allograft rejection_Homo sapiens_hsa05330	0.77336826
54	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.76655761
55	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.76058523
56	Pancreatic secretion_Homo sapiens_hsa04972	0.74667515
57	Antigen processing and presentation_Homo sapiens_hsa04612	0.74220360
58	Basal transcription factors_Homo sapiens_hsa03022	0.71823798
59	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.70813961
60	Nitrogen metabolism_Homo sapiens_hsa00910	0.70274147
61	Linoleic acid metabolism_Homo sapiens_hsa00591	0.69660130
62	Graft-versus-host disease_Homo sapiens_hsa05332	0.69232262
63	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.67892075
64	Glucagon signaling pathway_Homo sapiens_hsa04922	0.67177341
65	Tryptophan metabolism_Homo sapiens_hsa00380	0.64729473
66	Morphine addiction_Homo sapiens_hsa05032	0.64683481
67	Nicotine addiction_Homo sapiens_hsa05033	0.64307601
68	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.63358355
69	Purine metabolism_Homo sapiens_hsa00230	0.63309298
70	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.59573065
71	Tight junction_Homo sapiens_hsa04530	0.58071129
72	Homologous recombination_Homo sapiens_hsa03440	0.55601104
73	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.54370731
74	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.54006362
75	ECM-receptor interaction_Homo sapiens_hsa04512	0.53742870
76	Ether lipid metabolism_Homo sapiens_hsa00565	0.53480080
77	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.53445392
78	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.53342172
79	Alcoholism_Homo sapiens_hsa05034	0.51722847
80	Renin secretion_Homo sapiens_hsa04924	0.51123581
81	Basal cell carcinoma_Homo sapiens_hsa05217	0.50940138
82	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.48699256
83	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.47758580
84	Propanoate metabolism_Homo sapiens_hsa00640	0.37973874
85	Bile secretion_Homo sapiens_hsa04976	0.36949323
86	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.35944121
87	Viral myocarditis_Homo sapiens_hsa05416	0.35647334
88	mRNA surveillance pathway_Homo sapiens_hsa03015	0.34703269
89	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.33399336
90	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.33113570
91	RNA transport_Homo sapiens_hsa03013	0.32987939
92	Glycerolipid metabolism_Homo sapiens_hsa00561	0.31636445
93	MAPK signaling pathway_Homo sapiens_hsa04010	0.29145148
94	Metabolic pathways_Homo sapiens_hsa01100	0.27499507
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.26219353
96	Fatty acid elongation_Homo sapiens_hsa00062	0.25468929
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.25457812
98	Insulin resistance_Homo sapiens_hsa04931	0.25207506
99	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.23215120
100	Cardiac muscle contraction_Homo sapiens_hsa04260	0.23160905

POM121L6P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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