ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	6.89413275
2	translational termination (GO:0006415)	6.62684254
3	establishment of protein localization to mitochondrial membrane (GO:0090151)	6.18814228
4	alkaloid metabolic process (GO:0009820)	6.07788942
5	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	5.44670325
6	translational elongation (GO:0006414)	5.35455646
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.32917371
8	cellular protein complex disassembly (GO:0043624)	5.27335341
9	cotranslational protein targeting to membrane (GO:0006613)	5.23770917
10	protein targeting to ER (GO:0045047)	5.12326849
11	dopamine biosynthetic process (GO:0042416)	5.09956621
12	inner mitochondrial membrane organization (GO:0007007)	5.01505616
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.94175937
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.81325527
15	positive regulation of growth hormone secretion (GO:0060124)	4.79571546
16	protein localization to endoplasmic reticulum (GO:0070972)	4.75122809
17	viral life cycle (GO:0019058)	4.73953692
18	ribosomal small subunit assembly (GO:0000028)	4.60255603
19	tyrosine metabolic process (GO:0006570)	4.57967410
20	regulation of hexokinase activity (GO:1903299)	4.54426959
21	regulation of glucokinase activity (GO:0033131)	4.54426959
22	indole-containing compound catabolic process (GO:0042436)	4.49576668
23	indolalkylamine catabolic process (GO:0046218)	4.49576668
24	tryptophan catabolic process (GO:0006569)	4.49576668
25	regulation of dopamine secretion (GO:0014059)	4.44845838
26	protein complex disassembly (GO:0043241)	4.41444940
27	response to insecticide (GO:0017085)	4.39794364
28	kynurenine metabolic process (GO:0070189)	4.37361539
29	tryptophan metabolic process (GO:0006568)	4.35350421
30	sequestering of actin monomers (GO:0042989)	4.30424739
31	indolalkylamine metabolic process (GO:0006586)	4.24459159
32	macromolecular complex disassembly (GO:0032984)	4.21853522
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.12504364
34	NADH dehydrogenase complex assembly (GO:0010257)	4.12504364
35	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.12504364
36	translational initiation (GO:0006413)	4.09932967
37	hematopoietic stem cell proliferation (GO:0071425)	4.01333501
38	ribosomal small subunit biogenesis (GO:0042274)	3.99727002
39	positive regulation of microtubule polymerization or depolymerization (GO:0031112)	3.86486998
40	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.81217497
41	pseudouridine synthesis (GO:0001522)	3.79481582
42	maturation of SSU-rRNA (GO:0030490)	3.77022752
43	catecholamine biosynthetic process (GO:0042423)	3.76092243
44	catechol-containing compound biosynthetic process (GO:0009713)	3.76092243
45	benzene-containing compound metabolic process (GO:0042537)	3.75158487
46	dopamine transport (GO:0015872)	3.70428150
47	mating behavior (GO:0007617)	3.69880594
48	fucose catabolic process (GO:0019317)	3.67877054
49	L-fucose metabolic process (GO:0042354)	3.67877054
50	L-fucose catabolic process (GO:0042355)	3.67877054
51	toxin metabolic process (GO:0009404)	3.65902274
52	cellular response to nicotine (GO:0071316)	3.65168097
53	growth hormone secretion (GO:0030252)	3.59921370
54	synaptic transmission, dopaminergic (GO:0001963)	3.53184678
55	lateral sprouting from an epithelium (GO:0060601)	3.49614952
56	cilium or flagellum-dependent cell motility (GO:0001539)	3.46851879
57	synapsis (GO:0007129)	3.45291705
58	midbrain development (GO:0030901)	3.42776105
59	norepinephrine metabolic process (GO:0042415)	3.41722042
60	regulation of growth hormone secretion (GO:0060123)	3.41122578
61	chaperone-mediated protein complex assembly (GO:0051131)	3.39537585
62	protein complex biogenesis (GO:0070271)	3.38197870
63	chaperone-mediated protein transport (GO:0072321)	3.37887405
64	protein targeting to membrane (GO:0006612)	3.34760115
65	ATP synthesis coupled proton transport (GO:0015986)	3.34273119
66	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.34273119
67	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.32486609
68	intracellular protein transmembrane import (GO:0044743)	3.28738558
69	NAD biosynthetic process (GO:0009435)	3.26177044
70	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.24572572
71	peristalsis (GO:0030432)	3.21109813
72	2-oxoglutarate metabolic process (GO:0006103)	3.21053689
73	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.20001510
74	positive regulation of microtubule polymerization (GO:0031116)	3.19677485
75	mitochondrial respiratory chain complex assembly (GO:0033108)	3.19413070
76	hindbrain development (GO:0030902)	3.15709711
77	basic amino acid transport (GO:0015802)	3.14114725
78	regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)	3.10382659
79	base-excision repair, AP site formation (GO:0006285)	3.09639916
80	aromatic amino acid family metabolic process (GO:0009072)	3.08780348
81	pyrimidine nucleobase catabolic process (GO:0006208)	3.07224134
82	indole-containing compound metabolic process (GO:0042430)	3.07043207
83	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.06139043
84	auditory behavior (GO:0031223)	3.02790254
85	positive regulation of gastrulation (GO:2000543)	3.01148493
86	behavioral response to nicotine (GO:0035095)	2.96745668
87	neuronal action potential propagation (GO:0019227)	2.94773439
88	single strand break repair (GO:0000012)	2.93912638
89	cellular biogenic amine catabolic process (GO:0042402)	2.92008216
90	amine catabolic process (GO:0009310)	2.92008216
91	mRNA catabolic process (GO:0006402)	2.91847749
92	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.91415226
93	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.90172536
94	multicellular organismal aging (GO:0010259)	2.88034088
95	ribosomal large subunit biogenesis (GO:0042273)	2.87902091
96	phenol-containing compound biosynthetic process (GO:0046189)	2.82792045
97	cell wall macromolecule catabolic process (GO:0016998)	2.80069989
98	spinal cord motor neuron differentiation (GO:0021522)	2.78686133
99	regulation of sarcomere organization (GO:0060297)	2.78175780
100	dendritic spine morphogenesis (GO:0060997)	2.76926698

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.68339846
2	VDR_22108803_ChIP-Seq_LS180_Human	3.60797392
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.25209776
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.20634142
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.82460176
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.61331705
7	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.51393897
8	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.29271191
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.23381445
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.23096567
11	FUS_26573619_Chip-Seq_HEK293_Human	2.22868886
12	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.22734436
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.09061176
14	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.07326843
15	AR_21572438_ChIP-Seq_LNCaP_Human	2.04595128
16	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.00530740
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.00260568
18	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.00027768
19	DROSHA_22980978_ChIP-Seq_HELA_Human	1.97779665
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.97322023
21	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.96376323
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.92758161
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.86934150
24	REST_21632747_ChIP-Seq_MESCs_Mouse	1.82172634
25	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.82155473
26	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.81321305
27	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.78130306
28	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.77564668
29	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.77245841
30	RNF2_27304074_Chip-Seq_NSC_Mouse	1.76783857
31	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.75633206
32	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.74816029
33	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.74143819
34	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.70502294
35	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.68047640
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.64643361
37	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.62252822
38	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.62238551
39	GATA1_22025678_ChIP-Seq_K562_Human	1.57973793
40	TAF15_26573619_Chip-Seq_HEK293_Human	1.50028206
41	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.49274347
42	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.46578696
43	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.46499987
44	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.46499987
45	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.44220094
46	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.43719071
47	P300_19829295_ChIP-Seq_ESCs_Human	1.42299272
48	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.41467931
49	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.35196180
50	* EWS_26573619_Chip-Seq_HEK293_Human	1.34435799
51	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.30133170
52	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29518982
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28107270
54	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.27835801
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27663501
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27663501
57	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.26297908
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.24082268
59	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.22585285
60	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.22139783
61	TP53_22573176_ChIP-Seq_HFKS_Human	1.21812580
62	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.21753143
63	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.21184935
64	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.19496445
65	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.18141301
66	MYC_19829295_ChIP-Seq_ESCs_Human	1.17479387
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16212463
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15749863
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.15749863
70	AR_20517297_ChIP-Seq_VCAP_Human	1.15656747
71	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.15111746
72	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14245625
73	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.12632514
74	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12309228
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.10680070
76	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.10222646
77	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.08789763
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07872367
79	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.06813133
80	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.05656170
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05347674
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.99564893
83	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.99494244
84	STAT3_23295773_ChIP-Seq_U87_Human	0.99367436
85	CTCF_27219007_Chip-Seq_Bcells_Human	0.99239757
86	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.98939775
87	MYC_18940864_ChIP-ChIP_HL60_Human	0.98519146
88	ER_23166858_ChIP-Seq_MCF-7_Human	0.98210112
89	AR_25329375_ChIP-Seq_VCAP_Human	0.97151131
90	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.97102759
91	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.96595240
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96398230
93	ETV1_20927104_ChIP-Seq_GIST48_Human	0.95665980
94	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.94158358
95	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.93224733
96	ERG_20517297_ChIP-Seq_VCAP_Human	0.93054992
97	NCOR_22424771_ChIP-Seq_293T_Human	0.92791391
98	TP53_16413492_ChIP-PET_HCT116_Human	0.91299015
99	TAF2_19829295_ChIP-Seq_ESCs_Human	0.91051526
100	* PRDM14_20953172_ChIP-Seq_ESCs_Human	0.90639117

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	5.20473354
2	MP0002102_abnormal_ear_morphology	3.42950973
3	MP0000566_synostosis	3.42936650
4	MP0009379_abnormal_foot_pigmentation	2.96907073
5	MP0001501_abnormal_sleep_pattern	2.80430392
6	MP0003283_abnormal_digestive_organ	2.72892700
7	MP0009046_muscle_twitch	2.65713755
8	MP0003136_yellow_coat_color	2.41197952
9	MP0002653_abnormal_ependyma_morphology	2.38985868
10	MP0004742_abnormal_vestibular_system	2.38317301
11	MP0000383_abnormal_hair_follicle	2.35763836
12	MP0001905_abnormal_dopamine_level	2.27494477
13	MP0001529_abnormal_vocalization	2.24231731
14	MP0010030_abnormal_orbit_morphology	2.22959050
15	MP0003567_abnormal_fetal_cardiomyocyte	2.14197029
16	MP0005171_absent_coat_pigmentation	2.13837705
17	MP0004133_heterotaxia	2.10701498
18	MP0002638_abnormal_pupillary_reflex	2.05497186
19	MP0008875_abnormal_xenobiotic_pharmacok	2.04291507
20	MP0000049_abnormal_middle_ear	1.93878693
21	MP0005551_abnormal_eye_electrophysiolog	1.91079471
22	MP0004142_abnormal_muscle_tone	1.78679381
23	MP0002139_abnormal_hepatobiliary_system	1.78622210
24	MP0002837_dystrophic_cardiac_calcinosis	1.70201325
25	MP0004924_abnormal_behavior	1.66792808
26	MP0005386_behavior/neurological_phenoty	1.66792808
27	MP0002234_abnormal_pharynx_morphology	1.66438567
28	MP0002938_white_spotting	1.64110164
29	MP0000026_abnormal_inner_ear	1.61953590
30	MP0002277_abnormal_respiratory_mucosa	1.59063302
31	MP0000631_abnormal_neuroendocrine_gland	1.56285875
32	MP0001485_abnormal_pinna_reflex	1.47644226
33	MP0002557_abnormal_social/conspecific_i	1.45829357
34	MP0002067_abnormal_sensory_capabilities	1.44002212
35	MP0009745_abnormal_behavioral_response	1.42636373
36	MP0002064_seizures	1.38897495
37	MP0005174_abnormal_tail_pigmentation	1.37390525
38	MP0002272_abnormal_nervous_system	1.30169427
39	MP0005083_abnormal_biliary_tract	1.15651153
40	MP0003950_abnormal_plasma_membrane	1.13555507
41	MP0002233_abnormal_nose_morphology	1.12496408
42	MP0003195_calcinosis	1.12281586
43	MP0003632_abnormal_nervous_system	1.11292260
44	MP0001486_abnormal_startle_reflex	1.11251582
45	MP0006072_abnormal_retinal_apoptosis	1.10525439
46	MP0002572_abnormal_emotion/affect_behav	1.10289498
47	MP0003718_maternal_effect	1.08604037
48	MP0002733_abnormal_thermal_nociception	1.08083035
49	MP0005377_hearing/vestibular/ear_phenot	1.08079873
50	MP0003878_abnormal_ear_physiology	1.08079873
51	MP0005195_abnormal_posterior_eye	1.08059071
52	MP0005253_abnormal_eye_physiology	1.07776595
53	MP0002928_abnormal_bile_duct	1.06795541
54	MP0003959_abnormal_lean_body	1.04929704
55	MP0008872_abnormal_physiological_respon	1.04841754
56	MP0003329_amyloid_beta_deposits	1.04724444
57	MP0000778_abnormal_nervous_system	1.03781272
58	MP0004043_abnormal_pH_regulation	1.03272087
59	MP0010678_abnormal_skin_adnexa	1.00420998
60	MP0003119_abnormal_digestive_system	1.00235800
61	MP0002229_neurodegeneration	0.98832569
62	MP0002876_abnormal_thyroid_physiology	0.97053872
63	MP0002752_abnormal_somatic_nervous	0.96647435
64	MP0001299_abnormal_eye_distance/	0.95883967
65	MP0001293_anophthalmia	0.95800061
66	MP0005084_abnormal_gallbladder_morpholo	0.94388260
67	MP0001970_abnormal_pain_threshold	0.91287351
68	MP0001963_abnormal_hearing_physiology	0.88361856
69	MP0006276_abnormal_autonomic_nervous	0.87593076
70	MP0004145_abnormal_muscle_electrophysio	0.87211832
71	MP0002932_abnormal_joint_morphology	0.86442943
72	MP0000372_irregular_coat_pigmentation	0.86105828
73	MP0001881_abnormal_mammary_gland	0.84549271
74	MP0010386_abnormal_urinary_bladder	0.82919171
75	MP0000750_abnormal_muscle_regeneration	0.82533373
76	MP0000462_abnormal_digestive_system	0.82210068
77	MP0005332_abnormal_amino_acid	0.81447595
78	MP0002063_abnormal_learning/memory/cond	0.81323527
79	MP0002882_abnormal_neuron_morphology	0.81139804
80	MP0003937_abnormal_limbs/digits/tail_de	0.80019411
81	MP0005085_abnormal_gallbladder_physiolo	0.78786722
82	MP0005266_abnormal_metabolism	0.78690040
83	MP0000955_abnormal_spinal_cord	0.78363007
84	MP0002152_abnormal_brain_morphology	0.76416432
85	MP0003879_abnormal_hair_cell	0.76268738
86	MP0002697_abnormal_eye_size	0.76014525
87	MP0003635_abnormal_synaptic_transmissio	0.75977987
88	MP0002751_abnormal_autonomic_nervous	0.75251138
89	MP0001968_abnormal_touch/_nociception	0.73869403
90	MP0000685_abnormal_immune_system	0.72541487
91	MP0004885_abnormal_endolymph	0.70694404
92	MP0005394_taste/olfaction_phenotype	0.68773135
93	MP0005499_abnormal_olfactory_system	0.68773135
94	MP0003011_delayed_dark_adaptation	0.67472176
95	MP0001944_abnormal_pancreas_morphology	0.67179346
96	MP0005381_digestive/alimentary_phenotyp	0.67040281
97	MP0005391_vision/eye_phenotype	0.66644111
98	MP0001286_abnormal_eye_development	0.66501778
99	MP0006036_abnormal_mitochondrial_physio	0.66177365
100	MP0008995_early_reproductive_senescence	0.62381373

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Limb dystonia (HP:0002451)	6.94623938
2	Reticulocytopenia (HP:0001896)	6.71025322
3	Abnormal number of erythroid precursors (HP:0012131)	4.98754223
4	Abnormality of cells of the erythroid lineage (HP:0012130)	4.87358793
5	Global brain atrophy (HP:0002283)	4.77777036
6	Duplicated collecting system (HP:0000081)	4.56877642
7	Congenital stationary night blindness (HP:0007642)	4.29315009
8	Abnormality of the renal collecting system (HP:0004742)	4.28176295
9	Febrile seizures (HP:0002373)	4.09053852
10	Abnormality of midbrain morphology (HP:0002418)	3.69866730
11	Molar tooth sign on MRI (HP:0002419)	3.69866730
12	Nephronophthisis (HP:0000090)	3.57364914
13	Pallor (HP:0000980)	3.55139324
14	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.54062086
15	Pancreatic cysts (HP:0001737)	3.44633835
16	Vacuolated lymphocytes (HP:0001922)	3.41254570
17	3-Methylglutaconic aciduria (HP:0003535)	3.34940903
18	Abnormal biliary tract physiology (HP:0012439)	3.28997258
19	Bile duct proliferation (HP:0001408)	3.28997258
20	Parakeratosis (HP:0001036)	3.18986928
21	Hypothermia (HP:0002045)	3.15018293
22	True hermaphroditism (HP:0010459)	3.13265975
23	Congenital, generalized hypertrichosis (HP:0004540)	3.04349631
24	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.98124743
25	Pancreatic fibrosis (HP:0100732)	2.97245208
26	Abnormal number of incisors (HP:0011064)	2.96163396
27	Abnormality of the pons (HP:0007361)	2.92528365
28	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.84205244
29	Anophthalmia (HP:0000528)	2.83961238
30	Macrocytic anemia (HP:0001972)	2.81299641
31	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.80995098
32	Concave nail (HP:0001598)	2.79380208
33	Hypoplasia of the pons (HP:0012110)	2.75249491
34	Focal motor seizures (HP:0011153)	2.68544131
35	Abnormality of the renal medulla (HP:0100957)	2.68024847
36	Abnormality of the fovea (HP:0000493)	2.61888766
37	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.60305872
38	Abnormality of alanine metabolism (HP:0010916)	2.60305872
39	Hyperalaninemia (HP:0003348)	2.60305872
40	Partial agenesis of the corpus callosum (HP:0001338)	2.60184550
41	Abnormal pupillary function (HP:0007686)	2.51091806
42	Sclerocornea (HP:0000647)	2.48540315
43	Morphological abnormality of the pyramidal tract (HP:0002062)	2.47914124
44	Abnormality of pyrimidine metabolism (HP:0004353)	2.47350498
45	Bifid tongue (HP:0010297)	2.41213170
46	Fibular hypoplasia (HP:0003038)	2.37994228
47	Renal cortical cysts (HP:0000803)	2.34765190
48	Ureteral duplication (HP:0000073)	2.34360259
49	Oligodactyly (hands) (HP:0001180)	2.31753397
50	Increased cerebral lipofuscin (HP:0011813)	2.30818695
51	Tachypnea (HP:0002789)	2.30564690
52	Duplication of thumb phalanx (HP:0009942)	2.22825491
53	Cystic liver disease (HP:0006706)	2.20307446
54	Abnormality of reticulocytes (HP:0004312)	2.18244856
55	Chromsome breakage (HP:0040012)	2.12861208
56	Absent thumb (HP:0009777)	2.12191353
57	Abnormality of DNA repair (HP:0003254)	2.06340582
58	Ectopic kidney (HP:0000086)	2.04093380
59	Birth length less than 3rd percentile (HP:0003561)	2.03749469
60	Impaired smooth pursuit (HP:0007772)	2.02593118
61	Growth hormone deficiency (HP:0000824)	2.00713372
62	Abnormal rod and cone electroretinograms (HP:0008323)	1.98621501
63	Abnormality of the renal cortex (HP:0011035)	1.97332375
64	Abnormal ciliary motility (HP:0012262)	1.94995458
65	Bilateral microphthalmos (HP:0007633)	1.91030901
66	Spastic tetraparesis (HP:0001285)	1.85205476
67	Furrowed tongue (HP:0000221)	1.84819866
68	Anencephaly (HP:0002323)	1.83506786
69	Pendular nystagmus (HP:0012043)	1.81932751
70	Hemiparesis (HP:0001269)	1.81440517
71	Medial flaring of the eyebrow (HP:0010747)	1.78972146
72	Acute necrotizing encephalopathy (HP:0006965)	1.78467502
73	Inability to walk (HP:0002540)	1.78246720
74	Encephalitis (HP:0002383)	1.74538324
75	Choroideremia (HP:0001139)	1.72763062
76	Abnormality of the 4th metacarpal (HP:0010012)	1.71329817
77	Abnormal hemoglobin (HP:0011902)	1.69553048
78	Prominent supraorbital ridges (HP:0000336)	1.68474848
79	Tubular atrophy (HP:0000092)	1.68455808
80	Gait imbalance (HP:0002141)	1.67132535
81	Bony spicule pigmentary retinopathy (HP:0007737)	1.66773524
82	Long nose (HP:0003189)	1.66752336
83	Abnormal albumin level (HP:0012116)	1.66520678
84	Hypoalbuminemia (HP:0003073)	1.66520678
85	Intellectual disability, progressive (HP:0006887)	1.66222605
86	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.65557632
87	Hypotelorism (HP:0000601)	1.63771379
88	Triphalangeal thumb (HP:0001199)	1.63322435
89	Congenital hepatic fibrosis (HP:0002612)	1.63260046
90	Short tibia (HP:0005736)	1.62581276
91	Male pseudohermaphroditism (HP:0000037)	1.61577551
92	Postaxial hand polydactyly (HP:0001162)	1.60959234
93	Increased hepatocellular lipid droplets (HP:0006565)	1.60273599
94	Protruding tongue (HP:0010808)	1.59075279
95	Abnormality of the incisor (HP:0000676)	1.58812088
96	Lipid accumulation in hepatocytes (HP:0006561)	1.58759881
97	Fibular aplasia (HP:0002990)	1.57542458
98	Dyskinesia (HP:0100660)	1.57350522
99	Postaxial foot polydactyly (HP:0001830)	1.57060313
100	Abnormal respiratory epithelium morphology (HP:0012253)	1.56707344

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	GRK1	4.17889211
2	MAPKAPK5	3.95801110
3	PNCK	3.90563624
4	ADRBK2	3.48136838
5	MAPK13	3.01381090
6	MAP3K4	2.62170470
7	DYRK3	2.54258478
8	DYRK2	2.39535290
9	PASK	2.32587875
10	VRK2	2.22470386
11	WNK4	2.16656958
12	WNK3	2.08430466
13	WEE1	2.07984651
14	MAP2K7	2.04986522
15	EPHB2	2.02126504
16	MAP4K2	1.85735220
17	VRK1	1.78863162
18	MARK1	1.71266361
19	PINK1	1.67169983
20	GRK7	1.61238859
21	NTRK3	1.57206908
22	MAPK15	1.54839500
23	ZAK	1.54260034
24	NUAK1	1.51110412
25	DYRK1A	1.46994970
26	TIE1	1.42872012
27	DDR2	1.38865436
28	NTRK2	1.38715335
29	FGFR3	1.36717195
30	TYRO3	1.35234969
31	CAMK2B	1.26381509
32	MKNK1	1.25637428
33	LIMK1	1.19945491
34	NME1	1.17944671
35	UHMK1	1.17601243
36	MKNK2	1.16222259
37	DAPK2	1.14493167
38	NEK2	1.14372795
39	RPS6KA5	1.14048905
40	CCNB1	1.14027208
41	ADRBK1	1.07014067
42	TGFBR1	1.05259488
43	EEF2K	0.97314485
44	PRKCG	0.90113510
45	PLK4	0.84088250
46	CDK3	0.82732332
47	FGFR2	0.79173006
48	MAPK12	0.79152152
49	IRAK1	0.78037396
50	TLK1	0.75860256
51	TAF1	0.72685571
52	NEK9	0.71583856
53	RPS6KB2	0.67283861
54	PKN1	0.66731149
55	PIK3CA	0.64695052
56	MAP2K2	0.62952888
57	MAPKAPK3	0.62919273
58	TRPM7	0.61194582
59	CHEK2	0.60071735
60	MAP2K4	0.59091863
61	PIK3CG	0.58381719
62	TAOK3	0.58242147
63	TAOK1	0.57985519
64	INSRR	0.57381957
65	CAMK2G	0.55389169
66	KIT	0.54385234
67	DYRK1B	0.52261238
68	CAMK2A	0.51855135
69	TAOK2	0.51262328
70	MAPK4	0.50361667
71	CDK11A	0.49255934
72	CAMK2D	0.48883579
73	CAMK1D	0.46786259
74	CAMK4	0.45889756
75	OBSCN	0.43831140
76	JAK3	0.43404267
77	CDK5	0.42492374
78	TSSK6	0.42077296
79	CDK15	0.41596138
80	PRKACA	0.38857647
81	IRAK4	0.38628715
82	PRKACB	0.35762373
83	CDK18	0.34958421
84	CSNK1A1	0.34678364
85	ARAF	0.34246358
86	PHKG2	0.32817093
87	PHKG1	0.32817093
88	SYK	0.32384450
89	MAP2K1	0.28895408
90	BMPR1B	0.27595341
91	RPS6KA6	0.27013966
92	WNK1	0.25610937
93	EPHA4	0.25449234
94	MAPK3	0.24383568
95	CDC42BPA	0.24257664
96	MATK	0.24048473
97	CLK1	0.23697905
98	PRKCB	0.22882332
99	INSR	0.21951810
100	PRKCQ	0.20973070

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.17617959
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.03636985
3	Linoleic acid metabolism_Homo sapiens_hsa00591	3.77450783
4	Parkinsons disease_Homo sapiens_hsa05012	2.97253658
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.93887217
6	Ether lipid metabolism_Homo sapiens_hsa00565	2.89836799
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.78595555
8	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.50626683
9	Nicotine addiction_Homo sapiens_hsa05033	2.45903166
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.42229038
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.17463765
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.09640940
13	Phototransduction_Homo sapiens_hsa04744	2.05166561
14	Huntingtons disease_Homo sapiens_hsa05016	1.90574387
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.73662628
16	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.68082353
17	Alzheimers disease_Homo sapiens_hsa05010	1.64258599
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.64224139
19	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.59701882
20	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.56637562
21	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.53782337
22	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.50332730
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.43078746
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.41080013
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.39368410
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.33605188
27	Basal transcription factors_Homo sapiens_hsa03022	1.33210143
28	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.31674051
29	Taste transduction_Homo sapiens_hsa04742	1.31669334
30	Tyrosine metabolism_Homo sapiens_hsa00350	1.31390720
31	Serotonergic synapse_Homo sapiens_hsa04726	1.20374255
32	Histidine metabolism_Homo sapiens_hsa00340	1.18354020
33	Chemical carcinogenesis_Homo sapiens_hsa05204	1.18346141
34	Cocaine addiction_Homo sapiens_hsa05030	1.17987874
35	Morphine addiction_Homo sapiens_hsa05032	1.09748337
36	Basal cell carcinoma_Homo sapiens_hsa05217	1.07961719
37	Cholinergic synapse_Homo sapiens_hsa04725	1.07511545
38	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.06013374
39	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.04540669
40	Butanoate metabolism_Homo sapiens_hsa00650	1.04102321
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.04035690
42	Glutamatergic synapse_Homo sapiens_hsa04724	1.03744674
43	GABAergic synapse_Homo sapiens_hsa04727	0.98037316
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.97617643
45	Olfactory transduction_Homo sapiens_hsa04740	0.95408474
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.84958402
47	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.84722231
48	RNA polymerase_Homo sapiens_hsa03020	0.83860031
49	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.81807990
50	Selenocompound metabolism_Homo sapiens_hsa00450	0.80976352
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.80397332
52	Protein export_Homo sapiens_hsa03060	0.78089063
53	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.75802620
54	Circadian entrainment_Homo sapiens_hsa04713	0.75582906
55	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.73741594
56	Fanconi anemia pathway_Homo sapiens_hsa03460	0.73281019
57	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.69549874
58	Caffeine metabolism_Homo sapiens_hsa00232	0.65087022
59	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.64528810
60	Homologous recombination_Homo sapiens_hsa03440	0.64112165
61	Retinol metabolism_Homo sapiens_hsa00830	0.63552139
62	Bile secretion_Homo sapiens_hsa04976	0.62217376
63	Base excision repair_Homo sapiens_hsa03410	0.61466641
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.60700203
65	Dopaminergic synapse_Homo sapiens_hsa04728	0.57631950
66	Sulfur relay system_Homo sapiens_hsa04122	0.55054087
67	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.54385622
68	Amphetamine addiction_Homo sapiens_hsa05031	0.53506923
69	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.53015302
70	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.50363845
71	RNA degradation_Homo sapiens_hsa03018	0.48894103
72	Pyruvate metabolism_Homo sapiens_hsa00620	0.47599115
73	ABC transporters_Homo sapiens_hsa02010	0.46669008
74	Calcium signaling pathway_Homo sapiens_hsa04020	0.45167344
75	Pyrimidine metabolism_Homo sapiens_hsa00240	0.44960653
76	Purine metabolism_Homo sapiens_hsa00230	0.44615294
77	Metabolic pathways_Homo sapiens_hsa01100	0.43976092
78	Alcoholism_Homo sapiens_hsa05034	0.41635349
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41298925
80	GnRH signaling pathway_Homo sapiens_hsa04912	0.39562753
81	Glutathione metabolism_Homo sapiens_hsa00480	0.39294552
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.38872415
83	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.38317657
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33392575
85	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.32368868
86	Sulfur metabolism_Homo sapiens_hsa00920	0.31942380
87	Spliceosome_Homo sapiens_hsa03040	0.30160450
88	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.30144818
89	One carbon pool by folate_Homo sapiens_hsa00670	0.29086705
90	Asthma_Homo sapiens_hsa05310	0.28324743
91	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.26090124
92	Collecting duct acid secretion_Homo sapiens_hsa04966	0.24358457
93	Axon guidance_Homo sapiens_hsa04360	0.24039398
94	Ras signaling pathway_Homo sapiens_hsa04014	0.23137786
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.23045469
96	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.20844672
97	Salivary secretion_Homo sapiens_hsa04970	0.20724166
98	Long-term depression_Homo sapiens_hsa04730	0.19787922
99	Gastric acid secretion_Homo sapiens_hsa04971	0.19785966
100	Insulin secretion_Homo sapiens_hsa04911	0.19456126

POM121L8P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »