POMGNT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type II transmembrane protein that resides in the Golgi apparatus. It participates in O-mannosyl glycosylation and is specific for alpha linked terminal mannose. Mutations in this gene may be associated with muscle-eye-brain disease and several congenital muscular dystrophies. Alternatively spliced transcript variants that encode different protein isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1rRNA transcription (GO:0009303)9.15818067
2positive regulation of signal transduction by p53 class mediator (GO:1901798)8.82506480
3macroautophagy (GO:0016236)8.66886297
4induction of positive chemotaxis (GO:0050930)7.38905575
5positive regulation of vascular permeability (GO:0043117)6.83370397
6SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)6.67631027
7UV protection (GO:0009650)5.66001312
8hair cell differentiation (GO:0035315)5.46445859
9myelin assembly (GO:0032288)5.29779595
10astrocyte differentiation (GO:0048708)5.25714218
11nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)5.13191783
12heart morphogenesis (GO:0003007)4.93799041
13erythrocyte maturation (GO:0043249)4.82285364
14regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)4.79779397
15hematopoietic stem cell differentiation (GO:0060218)4.61040178
16retina vasculature morphogenesis in camera-type eye (GO:0061299)4.46726319
17meiotic chromosome segregation (GO:0045132)4.38533778
18spinal cord development (GO:0021510)4.31046677
19positive regulation of positive chemotaxis (GO:0050927)4.27572992
20positive regulation of monocyte chemotaxis (GO:0090026)4.17493441
21regulation of positive chemotaxis (GO:0050926)4.08040632
22cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)4.07174431
23positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)4.05778686
24astrocyte development (GO:0014002)4.05670442
25positive regulation of defense response to virus by host (GO:0002230)4.00501670
26vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.91313166
27regulation of synapse maturation (GO:0090128)3.88296945
28protein targeting to lysosome (GO:0006622)3.75452338
29establishment of protein localization to vacuole (GO:0072666)3.75452338
30protein targeting to vacuole (GO:0006623)3.75452338
31ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.75017125
32plasma membrane repair (GO:0001778)3.67864032
33peroxisome organization (GO:0007031)3.56937361
34forebrain morphogenesis (GO:0048853)3.54904206
35lateral ventricle development (GO:0021670)3.53794010
36peroxisome fission (GO:0016559)3.51655606
37maintenance of protein location in nucleus (GO:0051457)3.51107117
38negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.50193725
39embryonic skeletal joint morphogenesis (GO:0060272)3.47039696
40chondroitin sulfate catabolic process (GO:0030207)3.43054381
41mitotic nuclear envelope reassembly (GO:0007084)3.42308894
42nuclear envelope reassembly (GO:0031468)3.42308894
43creatine metabolic process (GO:0006600)3.38062311
44carnitine metabolic process (GO:0009437)3.35611478
45resolution of meiotic recombination intermediates (GO:0000712)3.27280121
46negative regulation of potassium ion transmembrane transport (GO:1901380)3.26205785
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.22619756
48cytoskeletal anchoring at plasma membrane (GO:0007016)3.22221736
49positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.21676455
50regulation of integrin-mediated signaling pathway (GO:2001044)3.17266846
51sodium ion export (GO:0071436)3.14207352
52anatomical structure maturation (GO:0071695)3.13015231
53inositol phosphate-mediated signaling (GO:0048016)3.10097764
54regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.08201057
55glomerulus development (GO:0032835)3.07200384
56cellular potassium ion homeostasis (GO:0030007)3.06350937
57central nervous system myelination (GO:0022010)3.05832787
58axon ensheathment in central nervous system (GO:0032291)3.05832787
59I-kappaB kinase/NF-kappaB signaling (GO:0007249)3.04168256
60positive regulation of protein targeting to membrane (GO:0090314)3.03479873
61energy homeostasis (GO:0097009)3.03392313
62regulation of monocyte chemotaxis (GO:0090025)3.00397940
63cytoplasmic sequestering of transcription factor (GO:0042994)2.98458660
64negative regulation of adherens junction organization (GO:1903392)2.97781688
65negative regulation of focal adhesion assembly (GO:0051895)2.97781688
66negative regulation of cell junction assembly (GO:1901889)2.97781688
67cellular response to pH (GO:0071467)2.97249753
68synaptonemal complex assembly (GO:0007130)2.97193627
69synaptic vesicle maturation (GO:0016188)2.93524093
70response to phenylpropanoid (GO:0080184)2.92280230
71regulation of translation in response to stress (GO:0043555)2.91664761
72cell communication by electrical coupling (GO:0010644)2.90932382
73reciprocal DNA recombination (GO:0035825)2.88336658
74reciprocal meiotic recombination (GO:0007131)2.88336658
75hemidesmosome assembly (GO:0031581)2.87708898
76sarcomere organization (GO:0045214)2.87548004
77protein localization to endosome (GO:0036010)2.85826864
78positive regulation of fatty acid beta-oxidation (GO:0032000)2.83942760
79activation of protein kinase A activity (GO:0034199)2.83785381
80chaperone-mediated protein transport (GO:0072321)2.82167728
81tricarboxylic acid cycle (GO:0006099)2.82080672
82regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.81389586
83regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.79990872
84myoblast migration (GO:0051451)2.79499109
85cardiac myofibril assembly (GO:0055003)2.78541034
86hyaluronan catabolic process (GO:0030214)2.78169636
87JNK cascade (GO:0007254)2.77637294
88diacylglycerol metabolic process (GO:0046339)2.77050148
89iron-sulfur cluster assembly (GO:0016226)2.74871135
90metallo-sulfur cluster assembly (GO:0031163)2.74871135
91protein localization to vacuole (GO:0072665)2.73733533
92protein localization to lysosome (GO:0061462)2.73733533
93potassium ion import (GO:0010107)2.73532861
94negative regulation of macroautophagy (GO:0016242)2.72482947
95layer formation in cerebral cortex (GO:0021819)2.71705609
96muscle filament sliding (GO:0030049)2.70255432
97actin-myosin filament sliding (GO:0033275)2.70255432
98regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.69496750
99regulation of short-term neuronal synaptic plasticity (GO:0048172)2.68231823
100cysteine metabolic process (GO:0006534)2.67073668
101regulation of lymphocyte migration (GO:2000401)2.66162901
102histone H4 deacetylation (GO:0070933)2.65955533
103regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.64781739
104establishment of epithelial cell polarity (GO:0090162)2.64382405
105positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.64111156
106establishment of viral latency (GO:0019043)2.63387223
107locomotory exploration behavior (GO:0035641)2.63193927
108neuromuscular junction development (GO:0007528)2.63187804
109regulation of synapse structural plasticity (GO:0051823)2.62736845
110negative regulation of protein localization to cell surface (GO:2000009)2.62321202
111maintenance of protein localization in organelle (GO:0072595)2.62078871
112axon ensheathment (GO:0008366)2.61870708
113ensheathment of neurons (GO:0007272)2.61870708
114carnitine shuttle (GO:0006853)2.61379211
115cell communication involved in cardiac conduction (GO:0086065)2.59227711
116regulation of fatty acid beta-oxidation (GO:0031998)2.58470888
117potassium ion homeostasis (GO:0055075)2.58223062
118regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.57120674
119nerve growth factor signaling pathway (GO:0038180)2.57070496
120myelin maintenance (GO:0043217)2.56594972
121membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.56416363
122myelination (GO:0042552)2.55884415
123synaptonemal complex organization (GO:0070193)2.55720906
124regulation of signal transduction by p53 class mediator (GO:1901796)2.55380942
125regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.54848624
126regulation of membrane repolarization (GO:0060306)2.54407992
127positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.52629045
128regulation of skeletal muscle contraction (GO:0014819)2.51977165
129cardiac muscle contraction (GO:0060048)2.51665582
130establishment of mitochondrion localization (GO:0051654)2.51428068
131nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.51170256
132positive regulation of response to DNA damage stimulus (GO:2001022)2.49439881
133cell-cell junction maintenance (GO:0045217)2.48401759
134regulation of calcium ion transmembrane transport (GO:1903169)2.48384934
135regulation of calcium ion transmembrane transporter activity (GO:1901019)2.48384934
136regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.47567530
137cerebellar Purkinje cell layer development (GO:0021680)2.47408215
138positive regulation of potassium ion transport (GO:0043268)2.45469518
139positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.45148822
140transcription from RNA polymerase I promoter (GO:0006360)2.44234680
141regulation of protein polyubiquitination (GO:1902914)2.44075334
142membrane tubulation (GO:0097320)2.42971338
143membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.42487012
144early endosome to late endosome transport (GO:0045022)2.41472959
145regulation of endothelial cell chemotaxis (GO:2001026)2.40824712
146positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.40670057
147dendrite morphogenesis (GO:0048813)2.39470186
148sperm capacitation (GO:0048240)2.38566619
149thrombin receptor signaling pathway (GO:0070493)2.38394493
150myofibril assembly (GO:0030239)2.38244919
151amino-acid betaine metabolic process (GO:0006577)2.37739610
152negative regulation of inclusion body assembly (GO:0090084)2.36732775
153membrane repolarization (GO:0086009)2.36102429
154glutamate secretion (GO:0014047)2.34197443
155negative regulation of organelle assembly (GO:1902116)2.33706887
156ventricular cardiac muscle cell action potential (GO:0086005)2.32192830
157mating behavior (GO:0007617)2.32022327
158membrane repolarization during action potential (GO:0086011)2.31658342
159acyl-CoA biosynthetic process (GO:0071616)2.30562795
160thioester biosynthetic process (GO:0035384)2.30562795
161regulation of potassium ion transmembrane transport (GO:1901379)2.27365571
162protein targeting to Golgi (GO:0000042)2.26908891
163aspartate family amino acid catabolic process (GO:0009068)2.25851223
164regulation of potassium ion transmembrane transporter activity (GO:1901016)2.24716634
165regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.24493009
166sarcoplasmic reticulum calcium ion transport (GO:0070296)2.23736857
167protein targeting to plasma membrane (GO:0072661)2.23667108
168cellular sodium ion homeostasis (GO:0006883)2.23141086
169positive regulation of potassium ion transmembrane transport (GO:1901381)2.22965471
170negative regulation of cell size (GO:0045792)2.21475683
171actomyosin structure organization (GO:0031032)2.20875812
172carnitine transmembrane transport (GO:1902603)2.20154151
173establishment of protein localization to Golgi (GO:0072600)2.19830167
174regulation of acyl-CoA biosynthetic process (GO:0050812)2.19619746
175actin-mediated cell contraction (GO:0070252)2.18676520
176apical protein localization (GO:0045176)2.16983286
177amino-acid betaine transport (GO:0015838)2.16192923
178carnitine transport (GO:0015879)2.16192923
179stress fiber assembly (GO:0043149)2.15932833
180dendritic spine morphogenesis (GO:0060997)2.15214479
181neuronal action potential propagation (GO:0019227)2.14663764
182response to methylmercury (GO:0051597)2.14111561
183membrane depolarization during action potential (GO:0086010)2.12632647
184establishment of nucleus localization (GO:0040023)2.11772080
185fatty acid elongation (GO:0030497)2.11679172
186negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.11598388
187regulation of synaptic vesicle exocytosis (GO:2000300)2.11294620
188vocalization behavior (GO:0071625)2.11202466
189fatty acid transmembrane transport (GO:1902001)2.10524315
190neuromuscular process controlling balance (GO:0050885)2.09627156
191asymmetric protein localization (GO:0008105)2.09153177
192camera-type eye morphogenesis (GO:0048593)2.08827462
193synaptic vesicle exocytosis (GO:0016079)2.08187273
194relaxation of cardiac muscle (GO:0055119)2.06845316
195regulation of cell communication by electrical coupling (GO:0010649)2.06306902
196activation of MAPKKK activity (GO:0000185)17.1947572
197leukocyte aggregation (GO:0070486)11.3965687
198glycoprotein catabolic process (GO:0006516)11.3634205
199positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)10.5969241

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.65186573
2EZH2_22144423_ChIP-Seq_EOC_Human3.54034591
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.89225351
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.19719631
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.18900553
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18371420
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.17085389
8SREBP2_21459322_ChIP-Seq_LIVER_Mouse2.13873545
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11827958
10ELF1_20517297_ChIP-Seq_JURKAT_Human2.08819724
11ZNF263_19887448_ChIP-Seq_K562_Human2.06703768
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.05572743
13DROSHA_22980978_ChIP-Seq_HELA_Human2.02592832
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00786131
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.00551139
16RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.99261322
17RARB_27405468_Chip-Seq_BRAIN_Mouse1.99088979
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98185304
19SMC3_22415368_ChIP-Seq_MEFs_Mouse1.96716954
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.96486830
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.96486830
22ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.89366028
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81756521
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.80318553
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78798546
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78638101
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.78129076
28STAT1_20625510_ChIP-Seq_HELA_Human1.77415912
29ZNF274_21170338_ChIP-Seq_K562_Hela1.76648376
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73948811
31UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.73784660
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.72158814
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68259998
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66762319
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65870713
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.62208953
37P68_20966046_ChIP-Seq_HELA_Human1.60880900
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59836298
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59561049
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.58173508
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.56981540
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.56414003
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56327628
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55682605
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.53549666
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53456883
47ETS1_21867929_ChIP-Seq_TH2_Mouse1.50355304
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49317736
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46838284
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46138339
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.45989168
52KDM2B_26808549_Chip-Seq_K562_Human1.44553734
53CLOCK_20551151_ChIP-Seq_293T_Human1.42454093
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.42166187
55SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41631813
56TBX20_22328084_ChIP-Seq_HEART_Mouse1.37810383
57TBX20_22080862_ChIP-Seq_HEART_Mouse1.37810383
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.37440711
59ESR1_20079471_ChIP-ChIP_T-47D_Human1.37018724
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35909115
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35315673
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34909805
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.34858874
64* E2F1_20622854_ChIP-Seq_HELA_Human1.34731790
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33914104
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33034587
67REST_21632747_ChIP-Seq_MESCs_Mouse1.32341034
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32111055
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30386903
70LXR_22292898_ChIP-Seq_THP-1_Human1.29023567
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27491843
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25743283
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25213666
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24245769
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.19309895
76REST_18959480_ChIP-ChIP_MESCs_Mouse1.19148985
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.19105905
78CTCF_27219007_Chip-Seq_Bcells_Human1.18159635
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17953482
80TP53_16413492_ChIP-PET_HCT116_Human1.17399834
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.15581481
82GBX2_23144817_ChIP-Seq_PC3_Human1.15240190
83DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14050649
84JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.12817885
85SMC1_22415368_ChIP-Seq_MEFs_Mouse1.12161856
86* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11064910
87SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07914362
88AR_21572438_ChIP-Seq_LNCaP_Human1.07303175
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06827012
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05432839
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05192199
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04485275
93TET1_21490601_ChIP-Seq_MESCs_Mouse1.02940821
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02392614
95CREB1_26743006_Chip-Seq_LNCaP_Human1.02365393
96CTCF_20526341_ChIP-Seq_ESCs_Human1.00736023
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00189701
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99959224
99TCF7_22412390_ChIP-Seq_EML_Mouse0.99505829
100NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99490762
101KDM2B_26808549_Chip-Seq_JURKAT_Human0.99144168
102FOXP1_21924763_ChIP-Seq_HESCs_Human0.99034204
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98906145
104VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97338333
105* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97159659
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96963955
107TP63_22573176_ChIP-Seq_HFKS_Human0.96060936
108TP53_23651856_ChIP-Seq_MEFs_Mouse0.95952261
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95632620
110* SA1_27219007_Chip-Seq_Bcells_Human0.95419222
111RACK7_27058665_Chip-Seq_MCF-7_Human0.94949284
112ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94682994
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94097850
114SOX2_21211035_ChIP-Seq_LN229_Gbm0.93700914
115KDM2B_26808549_Chip-Seq_DND41_Human0.93401079
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93225157
117CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93179309
118KLF4_19829295_ChIP-Seq_ESCs_Human0.92994346
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92861964
120MYC_27129775_Chip-Seq_CORNEA_Mouse0.92188857
121IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91937247
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91926823
123SPI1_20517297_ChIP-Seq_HL60_Human0.91617799
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91602424
125CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91532755
126SMC4_20622854_ChIP-Seq_HELA_Human0.91468363
127SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91090701
128SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91090701
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.89375071
130RUNX1_27514584_Chip-Seq_MCF-7_Human0.89063619
131FOXA2_19822575_ChIP-Seq_HepG2_Human0.88746115
132AHR_22903824_ChIP-Seq_MCF-7_Human0.88693234
133RING1B_27294783_Chip-Seq_NPCs_Mouse0.88479969
134SOX11_22085726_ChIP-Seq_ESNs_Mouse0.88460064
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.88060871
136AR_19668381_ChIP-Seq_PC3_Human0.87367191
137NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86743235
138OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86135948
139MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85763443
140TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84737282
141GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84601878
142MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.84245329
143* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84231071
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82219286
145ISL1_27105846_Chip-Seq_CPCs_Mouse0.82070506
146CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81285391
147SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80767929
148RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.80659098
149TP53_22127205_ChIP-Seq_IMR90_Human0.80413355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy3.51271393
2MP0002837_dystrophic_cardiac_calcinosis3.19260086
3MP0002938_white_spotting3.01157818
4MP0004859_abnormal_synaptic_plasticity2.84915274
5MP0004145_abnormal_muscle_electrophysio2.77999140
6MP0000858_altered_metastatic_potential2.76194379
7MP0003385_abnormal_body_wall2.71182877
8MP0003786_premature_aging2.65117432
9MP0004036_abnormal_muscle_relaxation2.63220125
10MP0004084_abnormal_cardiac_muscle2.56413386
11MP0000747_muscle_weakness2.50521092
12MP0003283_abnormal_digestive_organ2.37347459
13MP0004270_analgesia2.37326516
14MP0000749_muscle_degeneration2.35466365
15MP0003329_amyloid_beta_deposits2.24636085
16MP0005623_abnormal_meninges_morphology2.23695657
17MP0008438_abnormal_cutaneous_collagen2.20677935
18MP0004947_skin_inflammation2.11438082
19MP0000013_abnormal_adipose_tissue2.09738417
20MP0005410_abnormal_fertilization2.00538031
21MP0004233_abnormal_muscle_weight1.96293646
22MP0009780_abnormal_chondrocyte_physiolo1.86698253
23* MP0004087_abnormal_muscle_fiber1.85191879
24MP0004130_abnormal_muscle_cell1.84499820
25MP0003635_abnormal_synaptic_transmissio1.80948248
26MP0002638_abnormal_pupillary_reflex1.80544325
27MP0005330_cardiomyopathy1.78551752
28MP0010307_abnormal_tumor_latency1.72025765
29MP0004043_abnormal_pH_regulation1.71886772
30MP0003115_abnormal_respiratory_system1.71243798
31MP0004215_abnormal_myocardial_fiber1.68634382
32MP0002822_catalepsy1.66409867
33* MP0002269_muscular_atrophy1.63023548
34MP0002909_abnormal_adrenal_gland1.62169091
35MP0000920_abnormal_myelination1.60262079
36MP0000003_abnormal_adipose_tissue1.59131220
37MP0003705_abnormal_hypodermis_morpholog1.58818990
38MP0005620_abnormal_muscle_contractility1.55345184
39MP0002177_abnormal_outer_ear1.54206812
40* MP0000759_abnormal_skeletal_muscle1.53290794
41MP0004858_abnormal_nervous_system1.48628815
42MP0003137_abnormal_impulse_conducting1.47689396
43MP0004185_abnormal_adipocyte_glucose1.46924288
44* MP0002106_abnormal_muscle_physiology1.45091180
45MP0005375_adipose_tissue_phenotype1.41933752
46MP0004885_abnormal_endolymph1.40706949
47MP0005666_abnormal_adipose_tissue1.39753722
48MP0002064_seizures1.37275127
49MP0004272_abnormal_basement_membrane1.31795644
50MP0003646_muscle_fatigue1.31541220
51MP0002972_abnormal_cardiac_muscle1.30926110
52MP0002063_abnormal_learning/memory/cond1.28992772
53MP0002272_abnormal_nervous_system1.28858556
54MP0003880_abnormal_central_pattern1.27303748
55* MP0005369_muscle_phenotype1.27301401
56MP0003950_abnormal_plasma_membrane1.27242553
57MP0001299_abnormal_eye_distance/1.25609723
58MP0001958_emphysema1.25565450
59MP0009745_abnormal_behavioral_response1.25187480
60* MP0000750_abnormal_muscle_regeneration1.23375936
61MP0004085_abnormal_heartbeat1.22798835
62MP0002234_abnormal_pharynx_morphology1.22006163
63MP0003634_abnormal_glial_cell1.21436776
64MP0009379_abnormal_foot_pigmentation1.18608033
65MP0002734_abnormal_mechanical_nocicepti1.14880448
66MP0008775_abnormal_heart_ventricle1.13568852
67MP0009046_muscle_twitch1.12185417
68MP0002295_abnormal_pulmonary_circulatio1.11839192
69MP0010234_abnormal_vibrissa_follicle1.10467085
70MP0004484_altered_response_of1.08427100
71MP0010630_abnormal_cardiac_muscle1.07489230
72MP0005257_abnormal_intraocular_pressure1.06930875
73MP0003633_abnormal_nervous_system1.06897048
74MP0003755_abnormal_palate_morphology1.05147235
75MP0001765_abnormal_ion_homeostasis1.04636147
76MP0000537_abnormal_urethra_morphology1.03826578
77MP0006138_congestive_heart_failure1.03823308
78MP0005670_abnormal_white_adipose1.03190184
79MP0001440_abnormal_grooming_behavior1.03052163
80MP0005275_abnormal_skin_tensile1.01718460
81MP0005167_abnormal_blood-brain_barrier1.01703045
82MP0000462_abnormal_digestive_system0.96494743
83MP0003690_abnormal_glial_cell0.95869647
84MP0003279_aneurysm0.95406892
85MP0005083_abnormal_biliary_tract0.95123338
86MP0004147_increased_porphyrin_level0.94637251
87MP0000733_abnormal_muscle_development0.94467041
88MP0002108_abnormal_muscle_morphology0.93788838
89MP0000955_abnormal_spinal_cord0.93099922
90MP0008569_lethality_at_weaning0.92531854
91MP0005508_abnormal_skeleton_morphology0.91923036
92MP0000778_abnormal_nervous_system0.91457763
93MP0001486_abnormal_startle_reflex0.90762250
94MP0002572_abnormal_emotion/affect_behav0.90713859
95MP0001502_abnormal_circadian_rhythm0.90474209
96MP0000604_amyloidosis0.89726534
97MP0008961_abnormal_basal_metabolism0.88837082
98MP0003631_nervous_system_phenotype0.88218087
99MP0003221_abnormal_cardiomyocyte_apopto0.87787623
100MP0002896_abnormal_bone_mineralization0.87701201
101MP0000534_abnormal_ureter_morphology0.87602264
102MP0005171_absent_coat_pigmentation0.87431452
103MP0002090_abnormal_vision0.87379664
104MP0005385_cardiovascular_system_phenoty0.87085726
105MP0001544_abnormal_cardiovascular_syste0.87085726
106MP0009384_cardiac_valve_regurgitation0.87077770
107MP0000343_altered_response_to0.85558073
108MP0003566_abnormal_cell_adhesion0.84958085
109* MP0002066_abnormal_motor_capabilities/c0.84394401
110MP0010030_abnormal_orbit_morphology0.83516483
111MP0002089_abnormal_postnatal_growth/wei0.82902488
112MP0005423_abnormal_somatic_nervous0.81443443
113MP0004811_abnormal_neuron_physiology0.79910084
114MP0004924_abnormal_behavior0.79208104
115MP0005386_behavior/neurological_phenoty0.79208104
116MP0002733_abnormal_thermal_nociception0.79080956
117MP0002229_neurodegeneration0.79034564
118MP0002933_joint_inflammation0.78649656
119MP0003045_fibrosis0.78217709
120* MP0002882_abnormal_neuron_morphology0.77869713
121MP0010352_gastrointestinal_tract_polyps0.77071920
122MP0009250_abnormal_appendicular_skeleto0.75971580
123MP0001970_abnormal_pain_threshold0.75281697
124MP0003632_abnormal_nervous_system0.74722023
125MP0002114_abnormal_axial_skeleton0.72768077
126MP0005503_abnormal_tendon_morphology0.72732626
127MP0002249_abnormal_larynx_morphology0.71687957
128MP0000579_abnormal_nail_morphology0.70806037
129MP0003879_abnormal_hair_cell0.65312713
130MP0010368_abnormal_lymphatic_system0.64375518
131MP0003935_abnormal_craniofacial_develop0.63724459
132MP0002128_abnormal_blood_circulation0.62664346
133MP0005193_abnormal_anterior_eye0.62437719
134MP0002116_abnormal_craniofacial_bone0.61794374
135MP0005621_abnormal_cell_physiology0.61484214
136MP0006054_spinal_hemorrhage0.60499190
137MP0003453_abnormal_keratinocyte_physiol0.58416818
138MP0002877_abnormal_melanocyte_morpholog0.55761983
139MP0005165_increased_susceptibility_to0.53406498
140MP0008874_decreased_physiological_sensi0.50934608
141MP0002163_abnormal_gland_morphology0.49921634
142MP0002113_abnormal_skeleton_development0.48389983
143MP0005408_hypopigmentation0.47064423
144MP0001175_abnormal_lung_morphology0.46941906
145MP0004197_abnormal_fetal_growth/weight/0.46730288
146MP0005164_abnormal_response_to0.46433478
147MP0005197_abnormal_uvea_morphology0.46261558
148MP0005379_endocrine/exocrine_gland_phen0.46003199
149MP0000377_abnormal_hair_follicle0.44306489
150MP0005332_abnormal_amino_acid0.41904378
151MP0005501_abnormal_skin_physiology0.41268249
152* MP0000762_abnormal_tongue_morphology0.40469348
153MP0000467_abnormal_esophagus_morphology0.40337933
154MP0001915_intracranial_hemorrhage0.40064542
155MP0005023_abnormal_wound_healing0.39673692
156MP0005384_cellular_phenotype0.37823228

Predicted human phenotypes

RankGene SetZ-score
1Entropion (HP:0000621)8.46881979
2Poikiloderma (HP:0001029)6.27127641
3Fragile nails (HP:0001808)5.71444212
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.47832357
5Decreased subcutaneous fat (HP:0001002)5.27947796
6Mesangial abnormality (HP:0001966)5.23765798
7Abnormality of DNA repair (HP:0003254)4.95962349
8Rectal prolapse (HP:0002035)4.27481533
9Exercise-induced myalgia (HP:0003738)4.16672451
10Submucous cleft hard palate (HP:0000176)4.13918788
11Hyporeflexia of lower limbs (HP:0002600)3.92176378
12Abnormality of subcutaneous fat tissue (HP:0001001)3.83975753
13Papilledema (HP:0001085)3.76654453
14Brittle hair (HP:0002299)3.76506193
15Slow saccadic eye movements (HP:0000514)3.70519228
16Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.58070775
17Muscle fiber splitting (HP:0003555)3.52788737
18IgG deficiency (HP:0004315)3.46234078
19Difficulty running (HP:0009046)3.40193085
20Exercise-induced muscle cramps (HP:0003710)3.37711530
21Muscle hypertrophy of the lower extremities (HP:0008968)3.34589463
22Sudden death (HP:0001699)3.30665431
23Calf muscle hypertrophy (HP:0008981)3.30596403
24Termporal pattern (HP:0011008)3.25018848
25Insidious onset (HP:0003587)3.25018848
26Ileus (HP:0002595)3.21555316
27Increased IgM level (HP:0003496)3.18727212
28Sacral dimple (HP:0000960)3.18322315
29Increased variability in muscle fiber diameter (HP:0003557)3.18167972
30Cerebral inclusion bodies (HP:0100314)3.18037100
31Erythroderma (HP:0001019)3.17503892
32Congenital ichthyosiform erythroderma (HP:0007431)3.17218639
33Ectropion (HP:0000656)3.15040659
34Prominent metopic ridge (HP:0005487)3.13548682
35Death in childhood (HP:0003819)3.12712245
36Neurofibrillary tangles (HP:0002185)3.11737768
37Cerebral hypomyelination (HP:0006808)3.04476700
38Type 1 muscle fiber predominance (HP:0003803)3.04078743
39Cone-rod dystrophy (HP:0000548)2.97663594
40Myoglobinuria (HP:0002913)2.96373629
41Omphalocele (HP:0001539)2.96183987
42Keratitis (HP:0000491)2.95985020
43Abnormality of the calf musculature (HP:0001430)2.92736354
44Aplasia/Hypoplasia involving the musculature (HP:0001460)2.92588677
45Delayed closure of the anterior fontanelle (HP:0001476)2.87565785
46Abnormality of skeletal muscle fiber size (HP:0012084)2.84853427
47Akinesia (HP:0002304)2.81097937
48Conical tooth (HP:0000698)2.74978191
49Urinary glycosaminoglycan excretion (HP:0003541)2.70858219
50Mucopolysacchariduria (HP:0008155)2.70858219
51Degeneration of the lateral corticospinal tracts (HP:0002314)2.67469500
52Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.67469500
53Supranuclear gaze palsy (HP:0000605)2.67177519
54Abnormality of the metopic suture (HP:0005556)2.67052605
55Bundle branch block (HP:0011710)2.66058142
56Muscle fiber inclusion bodies (HP:0100299)2.65548834
57EMG: myopathic abnormalities (HP:0003458)2.65002571
58Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.63964002
59Premature rupture of membranes (HP:0001788)2.53799520
60Achilles tendon contracture (HP:0001771)2.53261523
61Increased connective tissue (HP:0009025)2.48921164
62Abnormality of polysaccharide metabolism (HP:0011012)2.47931851
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.47931851
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.47931851
65Myotonia (HP:0002486)2.43583028
66Abnormal albumin level (HP:0012116)2.40919086
67Hypoalbuminemia (HP:0003073)2.40919086
68* Difficulty climbing stairs (HP:0003551)2.39624406
69Scapular winging (HP:0003691)2.38729670
70Visual hallucinations (HP:0002367)2.37724433
71Ankyloglossia (HP:0010296)2.37098708
72Myokymia (HP:0002411)2.35137387
73Round ear (HP:0100830)2.33110600
74Upper limb amyotrophy (HP:0009129)2.31633133
75Distal upper limb amyotrophy (HP:0007149)2.31633133
76Nemaline bodies (HP:0003798)2.30371398
77Asymmetric septal hypertrophy (HP:0001670)2.27816488
78Abnormality of the Achilles tendon (HP:0005109)2.27761328
79Abnormality of incisor morphology (HP:0011063)2.27450792
80Abnormality of the corticospinal tract (HP:0002492)2.27006342
81Pheochromocytoma (HP:0002666)2.26771088
82Breast hypoplasia (HP:0003187)2.24855518
83Ankle clonus (HP:0011448)2.23556018
84Rocker bottom foot (HP:0001838)2.22637502
85Focal segmental glomerulosclerosis (HP:0000097)2.20804317
86Ventricular fibrillation (HP:0001663)2.19958979
87Vertebral arch anomaly (HP:0008438)2.19163875
88Abnormality of saccadic eye movements (HP:0000570)2.18315171
89Rapidly progressive (HP:0003678)2.17462621
90Prolonged QT interval (HP:0001657)2.17281253
91Thick nail (HP:0001805)2.15970807
92Abnormality of fatty-acid metabolism (HP:0004359)2.15219621
93Brushfield spots (HP:0001088)2.14832573
94Mildly elevated creatine phosphokinase (HP:0008180)2.13035700
95* Buphthalmos (HP:0000557)2.12261733
96Hemorrhage of the eye (HP:0011885)2.11069075
97Muscle stiffness (HP:0003552)2.09191297
98Protrusio acetabuli (HP:0003179)2.04846024
99Syncope (HP:0001279)2.04094739
100Diastasis recti (HP:0001540)2.02277523
101* Gowers sign (HP:0003391)2.01971979
102Myopathic facies (HP:0002058)2.01835510
103Broad metatarsal (HP:0001783)2.00582720
104Ridged nail (HP:0001807)1.98566941
105Distal arthrogryposis (HP:0005684)1.98264337
106Eosinophilia (HP:0001880)1.98112272
107Atrophic scars (HP:0001075)1.97980542
108Urinary urgency (HP:0000012)1.97654371
109Limb-girdle muscle atrophy (HP:0003797)1.96452961
110Right ventricular cardiomyopathy (HP:0011663)1.94981714
111Arthrogryposis multiplex congenita (HP:0002804)1.93680281
112Ventricular arrhythmia (HP:0004308)1.92738806
113Blue sclerae (HP:0000592)1.91199868
114Nephropathy (HP:0000112)1.91038611
115Increased serum pyruvate (HP:0003542)1.91019618
116Action tremor (HP:0002345)1.89481918
117Lower limb amyotrophy (HP:0007210)1.89372124
118Neuroendocrine neoplasm (HP:0100634)1.88250085
119Depressed nasal tip (HP:0000437)1.88238181
120Spinal rigidity (HP:0003306)1.88130999
121Abnormality of oral frenula (HP:0000190)1.86732144
122Cerebral aneurysm (HP:0004944)1.85921662
123Neck muscle weakness (HP:0000467)1.85904683
124Synostosis of carpal bones (HP:0005048)1.84582012
125Hypobetalipoproteinemia (HP:0003563)1.84523639
126Megalencephaly (HP:0001355)1.82109537
127Abnormality of the acetabulum (HP:0003170)1.81419796
128Atrial fibrillation (HP:0005110)1.81382118
129Foot dorsiflexor weakness (HP:0009027)1.80637912
130Ventricular tachycardia (HP:0004756)1.80558108
131Abdominal situs inversus (HP:0003363)1.78808337
132Abnormality of abdominal situs (HP:0011620)1.78808337
133Shallow orbits (HP:0000586)1.77994074
134Heart block (HP:0012722)1.77765747
135Lower limb muscle weakness (HP:0007340)1.77022665
136Abnormality of glycolysis (HP:0004366)1.76887043
137Primary atrial arrhythmia (HP:0001692)1.75905983
138Aplasia involving bones of the extremities (HP:0009825)1.75135467
139Aplasia involving bones of the upper limbs (HP:0009823)1.75135467
140Aplasia of the phalanges of the hand (HP:0009802)1.75135467
141Stridor (HP:0010307)1.74821557
142Abnormality of the foot musculature (HP:0001436)1.74697597
143EMG: neuropathic changes (HP:0003445)1.74363280
144Abnormal atrioventricular conduction (HP:0005150)1.73558273
145Decreased muscle mass (HP:0003199)1.73146838
146Ketoacidosis (HP:0001993)1.73022727
147Delusions (HP:0000746)1.72223684
148Centrally nucleated skeletal muscle fibers (HP:0003687)1.71980896
149Increased circulating renin level (HP:0000848)1.71955137
150Hammertoe (HP:0001765)1.70839280
151Focal seizures (HP:0007359)1.70750569
152Neoplasm of the peripheral nervous system (HP:0100007)1.68565354
153Delayed cranial suture closure (HP:0000270)1.68267759
154Onion bulb formation (HP:0003383)1.67761083
155Spastic gait (HP:0002064)1.67743796
156Abnormality of the right ventricle (HP:0001707)1.67159803
157Supraventricular arrhythmia (HP:0005115)1.67063195
158Diminished movement (HP:0002374)1.66614797
159Stage 5 chronic kidney disease (HP:0003774)1.66521223
160Athetosis (HP:0002305)1.64676604
161Lipoatrophy (HP:0100578)1.64571321
162Intention tremor (HP:0002080)1.63768027
163Supraventricular tachycardia (HP:0004755)1.63412767
164Diaphragmatic weakness (HP:0009113)1.63289078
165Distal lower limb amyotrophy (HP:0008944)1.62350830
166Rhabdomyolysis (HP:0003201)1.62311194
167Abnormal cortical bone morphology (HP:0003103)1.61870350
168Hand muscle atrophy (HP:0009130)1.61663595
169Bladder diverticulum (HP:0000015)1.61388708
170Insomnia (HP:0100785)1.61342945
171Hypoplastic nipples (HP:0002557)1.60790980
172Glomerulosclerosis (HP:0000096)1.60644532
173Hamartoma of the eye (HP:0010568)1.60289417
174Conjunctival telangiectasia (HP:0000524)1.60004295
175Scrotal hypoplasia (HP:0000046)1.59836204
176Resting tremor (HP:0002322)1.59809531
177Craniofacial dystonia (HP:0012179)1.59481943
178Cholelithiasis (HP:0001081)1.58900277
179* Type II lissencephaly (HP:0007260)1.58305423
180Abnormality of the lower motor neuron (HP:0002366)1.57433382
181Atrioventricular block (HP:0001678)1.57132378
182Supernumerary ribs (HP:0005815)1.55649799
183Choreoathetosis (HP:0001266)1.53111199
184Spastic paraplegia (HP:0001258)1.52047833
185Tubulointerstitial fibrosis (HP:0005576)1.48915421
186Personality changes (HP:0000751)1.48820418
187Vertebral compression fractures (HP:0002953)1.48175383
188Focal dystonia (HP:0004373)1.47249250

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK109.06513885
2MARK38.94172597
3STK113.23232490
4TRIB33.16472290
5STK393.06230529
6TTN2.91081701
7PIM12.81394674
8PDK32.67382898
9PDK42.67382898
10PRKD32.43454073
11WNK42.37450721
12PHKG22.18255960
13PHKG12.18255960
14MAP3K92.17269170
15PKN22.09234052
16KSR21.87865938
17NTRK11.86864327
18EPHB11.75832855
19OXSR11.74780286
20ICK1.70686452
21PAK61.67127510
22LMTK21.55582207
23PDK21.51858125
24EPHA41.51163922
25BCKDK1.48518767
26PAK31.45809778
27NLK1.45795523
28MAP3K131.44699541
29DMPK1.42200085
30OBSCN1.39286643
31NTRK31.37936805
32CAMK1G1.35822371
33EPHA31.33729132
34DDR21.33653003
35RIPK11.31256187
36MET1.30888654
37PNCK1.29916436
38PDGFRA1.27266631
39PTK2B1.25107829
40TXK1.24066451
41MAP3K41.21468848
42CAMKK11.16941979
43TYRO31.16481202
44MARK11.14643876
45EPHA21.13494328
46RET1.12180160
47SCYL21.11952017
48MAP3K21.11881734
49LATS21.11810934
50WNK11.11272939
51DAPK21.09474462
52CLK11.07630283
53TESK11.07581481
54PRKD21.07244210
55ERN11.03476521
56FER1.01877518
57PTK60.99760824
58PIK3CA0.96688447
59LIMK10.93400435
60MAP2K20.90816141
61NEK10.90634002
62TAOK20.90336615
63MAPKAPK50.90311257
64MARK20.90121456
65FGFR40.89637201
66CAMK2D0.88611389
67STK380.88074346
68ROCK20.87960255
69CDK50.87628248
70UHMK10.87599798
71MAP3K30.87533724
72CAMKK20.85639590
73PRKD10.85171483
74PTK20.84138545
75MAP2K40.83550635
76PDPK10.82584228
77PAK20.82494338
78MUSK0.82327951
79BMX0.80849246
80CAMK1D0.79500960
81ZAP700.78050828
82MINK10.77253599
83GSK3A0.76052480
84EEF2K0.74674611
85CAMK2B0.73514787
86ILK0.69076638
87FGFR20.67830800
88MYLK0.66204114
89LATS10.65906927
90PRKG20.64980509
91PIK3CG0.64750434
92AKT20.64273377
93MAP3K70.63939281
94ROCK10.63846458
95CAMK2A0.62427666
96NTRK20.61959481
97DAPK30.61625557
98MAP2K10.61008703
99PDK10.60764407
100IRAK30.60179300
101PRKCH0.59052703
102TAOK10.58886949
103EPHB20.58676446
104PDGFRB0.58248375
105SIK10.58113959
106CDK140.57413256
107CDK150.57297430
108MAPK120.56879488
109CDK190.56186816
110MAP3K10.55165444
111ARAF0.54904309
112CSNK1G20.54825794
113LRRK20.53552588
114PKN10.52240983
115MST1R0.52185038
116CAMK2G0.50710110
117CDC42BPA0.50568196
118MAP3K110.49561160
119MTOR0.49113724
120NME10.48994663
121CDK11A0.47734645
122CAMK10.47366273
123PRKCE0.45066509
124PIM20.44334862
125MELK0.43586430
126ERBB40.42489557
127MAP4K10.38978434
128MAPK110.38363462
129BRSK10.34961652
130KDR0.32473437
131CSNK1D0.32020874
132MAP2K30.29890085
133CSNK1G30.28970742
134PRKCI0.28328055
135CSNK1A1L0.25363386
136HIPK20.20357110
137MAPK140.20031693
138PINK10.19596826
139MOS0.17691068
140ABL20.16778872

Predicted pathways (KEGG)

RankGene SetZ-score
1SNARE interactions in vesicular transport_Homo sapiens_hsa041304.84871560
2Sulfur relay system_Homo sapiens_hsa041223.47968400
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.10530677
4NOD-like receptor signaling pathway_Homo sapiens_hsa046212.90164373
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.57227188
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.22928794
7Cardiac muscle contraction_Homo sapiens_hsa042602.05963701
8Propanoate metabolism_Homo sapiens_hsa006401.99736380
9TNF signaling pathway_Homo sapiens_hsa046681.94662979
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88251325
11Dilated cardiomyopathy_Homo sapiens_hsa054141.81180081
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.79349291
13Toxoplasmosis_Homo sapiens_hsa051451.79114922
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67697352
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62262183
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61187929
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.57938328
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.53102878
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52129275
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51249620
21Gastric acid secretion_Homo sapiens_hsa049711.47514683
22Butanoate metabolism_Homo sapiens_hsa006501.41308733
23Pyruvate metabolism_Homo sapiens_hsa006201.40968375
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.37257475
25Fatty acid metabolism_Homo sapiens_hsa012121.37108792
26Circadian entrainment_Homo sapiens_hsa047131.36730634
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36724701
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.35140854
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34857023
30Insulin secretion_Homo sapiens_hsa049111.34567618
31GABAergic synapse_Homo sapiens_hsa047271.34164940
32Nitrogen metabolism_Homo sapiens_hsa009101.34042781
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.33207889
34Renin secretion_Homo sapiens_hsa049241.33166174
35Sulfur metabolism_Homo sapiens_hsa009201.32997657
36Salivary secretion_Homo sapiens_hsa049701.31747670
37Glutamatergic synapse_Homo sapiens_hsa047241.24361517
38Fatty acid biosynthesis_Homo sapiens_hsa000611.24126323
39Pentose phosphate pathway_Homo sapiens_hsa000301.23858699
40Synaptic vesicle cycle_Homo sapiens_hsa047211.23833754
41Pancreatic secretion_Homo sapiens_hsa049721.23053006
42Fatty acid elongation_Homo sapiens_hsa000621.22613437
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20846525
44Long-term potentiation_Homo sapiens_hsa047201.20807021
45Other glycan degradation_Homo sapiens_hsa005111.19384450
46Oxytocin signaling pathway_Homo sapiens_hsa049211.16301741
47Amphetamine addiction_Homo sapiens_hsa050311.13623869
48Small cell lung cancer_Homo sapiens_hsa052221.11960260
49Oxidative phosphorylation_Homo sapiens_hsa001901.10500767
50Fatty acid degradation_Homo sapiens_hsa000711.10056531
51Parkinsons disease_Homo sapiens_hsa050121.09581887
52Dopaminergic synapse_Homo sapiens_hsa047281.09293146
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08002641
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07303451
55Alzheimers disease_Homo sapiens_hsa050101.06206012
56Morphine addiction_Homo sapiens_hsa050321.03119469
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03007326
58Carbon metabolism_Homo sapiens_hsa012001.02533247
59Gap junction_Homo sapiens_hsa045401.02028145
60Vascular smooth muscle contraction_Homo sapiens_hsa042701.01403100
61Cholinergic synapse_Homo sapiens_hsa047251.00493045
62Olfactory transduction_Homo sapiens_hsa047400.99759351
63Estrogen signaling pathway_Homo sapiens_hsa049150.99482124
64Leishmaniasis_Homo sapiens_hsa051400.98263026
65Cocaine addiction_Homo sapiens_hsa050300.97597869
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94096046
67Tight junction_Homo sapiens_hsa045300.93696135
68Glucagon signaling pathway_Homo sapiens_hsa049220.92030627
69ECM-receptor interaction_Homo sapiens_hsa045120.91788851
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91763430
71Protein digestion and absorption_Homo sapiens_hsa049740.90764643
72Phenylalanine metabolism_Homo sapiens_hsa003600.89099999
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87167832
74GnRH signaling pathway_Homo sapiens_hsa049120.87131233
75Long-term depression_Homo sapiens_hsa047300.86834929
76Regulation of autophagy_Homo sapiens_hsa041400.86690898
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85667061
78Focal adhesion_Homo sapiens_hsa045100.84605373
79Calcium signaling pathway_Homo sapiens_hsa040200.83584441
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.83546770
81Renal cell carcinoma_Homo sapiens_hsa052110.83526770
82MAPK signaling pathway_Homo sapiens_hsa040100.83322087
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82438687
84Nicotine addiction_Homo sapiens_hsa050330.80224654
85Vibrio cholerae infection_Homo sapiens_hsa051100.79921003
86Axon guidance_Homo sapiens_hsa043600.78750638
87cAMP signaling pathway_Homo sapiens_hsa040240.76908748
88Thyroid hormone synthesis_Homo sapiens_hsa049180.76061161
89Fructose and mannose metabolism_Homo sapiens_hsa000510.75802578
90AMPK signaling pathway_Homo sapiens_hsa041520.74088829
91Type II diabetes mellitus_Homo sapiens_hsa049300.73200732
92Bile secretion_Homo sapiens_hsa049760.73150974
93VEGF signaling pathway_Homo sapiens_hsa043700.73098918
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73074573
95Glioma_Homo sapiens_hsa052140.72720560
96Mineral absorption_Homo sapiens_hsa049780.72544907
97Chronic myeloid leukemia_Homo sapiens_hsa052200.72353149
98Rap1 signaling pathway_Homo sapiens_hsa040150.70314368
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.69857874
100Pancreatic cancer_Homo sapiens_hsa052120.69581525
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68990848
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67186526
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67110221
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66834797
105Glycerolipid metabolism_Homo sapiens_hsa005610.66432450
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.65004265
107Melanogenesis_Homo sapiens_hsa049160.64754681
108PPAR signaling pathway_Homo sapiens_hsa033200.64325145
109Insulin signaling pathway_Homo sapiens_hsa049100.63802280
110Dorso-ventral axis formation_Homo sapiens_hsa043200.63546071
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.63474392
112Taste transduction_Homo sapiens_hsa047420.63358787
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62745700
114Serotonergic synapse_Homo sapiens_hsa047260.61460934
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60745341
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60587368
117ABC transporters_Homo sapiens_hsa020100.60448673
118* Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60019066
119Ras signaling pathway_Homo sapiens_hsa040140.59618671
120Hippo signaling pathway_Homo sapiens_hsa043900.59405356
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54542921
122Tyrosine metabolism_Homo sapiens_hsa003500.54212956
123Prostate cancer_Homo sapiens_hsa052150.53690462
124Huntingtons disease_Homo sapiens_hsa050160.53455180
125Collecting duct acid secretion_Homo sapiens_hsa049660.52050307
126Steroid biosynthesis_Homo sapiens_hsa001000.51283187
127ErbB signaling pathway_Homo sapiens_hsa040120.51264535
128mTOR signaling pathway_Homo sapiens_hsa041500.51172149
129Insulin resistance_Homo sapiens_hsa049310.50813483
130Arginine biosynthesis_Homo sapiens_hsa002200.50168942
131Biosynthesis of amino acids_Homo sapiens_hsa012300.49710143
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49621969
133Fat digestion and absorption_Homo sapiens_hsa049750.49113735
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48565717
135Osteoclast differentiation_Homo sapiens_hsa043800.45876681
136Lysosome_Homo sapiens_hsa041420.43931753
137Bladder cancer_Homo sapiens_hsa052190.43355241
138Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43031776
139Amoebiasis_Homo sapiens_hsa051460.41459467
140Proteoglycans in cancer_Homo sapiens_hsa052050.41302850
141Phagosome_Homo sapiens_hsa041450.40280002
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.38086245
143Prion diseases_Homo sapiens_hsa050200.37537942
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36950518
145Sphingolipid metabolism_Homo sapiens_hsa006000.35859696
146Pathways in cancer_Homo sapiens_hsa052000.34103643
147Inositol phosphate metabolism_Homo sapiens_hsa005620.32327062
148Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30468514

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