POMP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome complex. The encoded protein is degraded before the maturation of the 20S proteasome is complete. A variant in the 5' UTR of this gene has been associated with KLICK syndrome, a rare skin disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.19405154
2ATP synthesis coupled proton transport (GO:0015986)7.59598097
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.59598097
4ribosomal small subunit biogenesis (GO:0042274)6.56092824
5viral transcription (GO:0019083)6.37033846
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.36343034
7translational termination (GO:0006415)6.17936838
8respiratory electron transport chain (GO:0022904)5.76861918
9ribosomal small subunit assembly (GO:0000028)5.76483739
10electron transport chain (GO:0022900)5.61068586
11cotranslational protein targeting to membrane (GO:0006613)5.55446066
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.51383856
13protein targeting to ER (GO:0045047)5.46216727
14maturation of SSU-rRNA (GO:0030490)5.44738573
15protein neddylation (GO:0045116)5.42371755
16establishment of protein localization to mitochondrial membrane (GO:0090151)5.28437691
17protein localization to endoplasmic reticulum (GO:0070972)5.24920575
18establishment of protein localization to endoplasmic reticulum (GO:0072599)5.20070656
19chaperone-mediated protein transport (GO:0072321)5.16925313
20translational elongation (GO:0006414)5.14327122
21viral life cycle (GO:0019058)5.02769647
22ribosomal large subunit biogenesis (GO:0042273)4.96743537
23cellular protein complex disassembly (GO:0043624)4.89940332
24* proteasome assembly (GO:0043248)4.70921762
25regulation of cellular amino acid metabolic process (GO:0006521)4.70672470
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.70529223
27mitochondrial respiratory chain complex I assembly (GO:0032981)4.70529223
28NADH dehydrogenase complex assembly (GO:0010257)4.70529223
29translational initiation (GO:0006413)4.69180209
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.61272406
31protein complex biogenesis (GO:0070271)4.56778807
32regulation of mitochondrial translation (GO:0070129)4.52123832
33termination of RNA polymerase III transcription (GO:0006386)4.47473327
34transcription elongation from RNA polymerase III promoter (GO:0006385)4.47473327
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.45579809
36translation (GO:0006412)4.43347986
37GTP biosynthetic process (GO:0006183)4.37274040
38CENP-A containing nucleosome assembly (GO:0034080)4.36837479
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.34754160
40chromatin remodeling at centromere (GO:0031055)4.29883685
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.24521771
42negative regulation of ligase activity (GO:0051352)4.24521771
43DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.24213934
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.21598548
45mitochondrial respiratory chain complex assembly (GO:0033108)4.19465590
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.13020862
47signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.13020862
48antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)4.09884814
49signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.09794037
50signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.09794037
51signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.09794037
52protein complex disassembly (GO:0043241)4.00061506
53signal transduction involved in DNA integrity checkpoint (GO:0072401)3.99171196
54signal transduction involved in DNA damage checkpoint (GO:0072422)3.99171196
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.98405876
56cullin deneddylation (GO:0010388)3.97317195
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.96989058
58signal transduction involved in cell cycle checkpoint (GO:0072395)3.94187888
59protein targeting to mitochondrion (GO:0006626)3.91263763
60establishment of protein localization to mitochondrion (GO:0072655)3.88069833
617-methylguanosine mRNA capping (GO:0006370)3.85700132
62macromolecular complex disassembly (GO:0032984)3.83255947
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.83038773
64RNA capping (GO:0036260)3.82917780
657-methylguanosine RNA capping (GO:0009452)3.82917780
66rRNA modification (GO:0000154)3.79492552
67ribonucleoprotein complex biogenesis (GO:0022613)3.73897932
68UTP biosynthetic process (GO:0006228)3.73610823
69purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.71101180
70cellular component biogenesis (GO:0044085)3.70458085
71regulation of cellular amine metabolic process (GO:0033238)3.68299167
72establishment of integrated proviral latency (GO:0075713)3.68153610
73purine nucleoside triphosphate biosynthetic process (GO:0009145)3.64898664
74protein deneddylation (GO:0000338)3.64350219
75protein localization to mitochondrion (GO:0070585)3.63007248
76protein targeting to membrane (GO:0006612)3.60894884
77cytochrome complex assembly (GO:0017004)3.58236864
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.55007881
79histone exchange (GO:0043486)3.53391027
80ATP biosynthetic process (GO:0006754)3.52194648
81oxidative phosphorylation (GO:0006119)3.47543128
82establishment of viral latency (GO:0019043)3.46502476
83hydrogen ion transmembrane transport (GO:1902600)3.45216817
84positive regulation of ligase activity (GO:0051351)3.44287035
85regulation of ligase activity (GO:0051340)3.42862778
86guanosine-containing compound biosynthetic process (GO:1901070)3.41297423
87pseudouridine synthesis (GO:0001522)3.41019113
88tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36305170
89RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36305170
90DNA damage response, detection of DNA damage (GO:0042769)3.36161474
91histone mRNA metabolic process (GO:0008334)3.30437554
92aldehyde catabolic process (GO:0046185)3.29998719
93transcription elongation from RNA polymerase I promoter (GO:0006362)3.26027007
94antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.25828169
95negative regulation of B cell apoptotic process (GO:0002903)3.25080282
96ribonucleoside triphosphate biosynthetic process (GO:0009201)3.24577551
97rRNA processing (GO:0006364)3.24493786
98UTP metabolic process (GO:0046051)3.23453871
99respiratory chain complex IV assembly (GO:0008535)3.18311754
100intracellular protein transmembrane import (GO:0044743)3.15704886
101DNA replication-independent nucleosome assembly (GO:0006336)3.15141783
102DNA replication-independent nucleosome organization (GO:0034724)3.15141783
103DNA double-strand break processing (GO:0000729)3.14774083
104hydrogen transport (GO:0006818)3.14704665
105nuclear-transcribed mRNA catabolic process (GO:0000956)3.13077381
106positive regulation of cell cycle arrest (GO:0071158)3.12733156
107negative regulation of protein ubiquitination (GO:0031397)3.12429509
108L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.11742504
109spliceosomal snRNP assembly (GO:0000387)3.10443076
110purine nucleobase biosynthetic process (GO:0009113)3.09337378
111rRNA methylation (GO:0031167)3.09336851
112rRNA metabolic process (GO:0016072)3.06377651
113DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.05848080
114inner mitochondrial membrane organization (GO:0007007)3.05268284
115proton transport (GO:0015992)3.05228503
116termination of RNA polymerase I transcription (GO:0006363)3.03502661
117regulation of ubiquitin-protein transferase activity (GO:0051438)3.03339176
118nucleobase-containing small molecule interconversion (GO:0015949)2.99656720
119mitochondrial transport (GO:0006839)2.99207542
120nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98376254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.90239946
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.24601615
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.88595703
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.45977713
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.45143684
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.92227914
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.88609755
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.76029142
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.73855514
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.55913949
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.46877524
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.36134747
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.32625876
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.06924388
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.02796910
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.75121700
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59412712
18VDR_23849224_ChIP-Seq_CD4+_Human2.58723800
19ELK1_19687146_ChIP-ChIP_HELA_Human2.54639794
20DCP1A_22483619_ChIP-Seq_HELA_Human2.41568306
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38613977
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.30743295
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30577689
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.28376019
25XRN2_22483619_ChIP-Seq_HELA_Human2.22062553
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11342358
27BP1_19119308_ChIP-ChIP_Hs578T_Human2.09685152
28FOXP3_21729870_ChIP-Seq_TREG_Human2.05763362
29TTF2_22483619_ChIP-Seq_HELA_Human2.02831955
30ELK1_22589737_ChIP-Seq_MCF10A_Human1.94282156
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91449343
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.89986063
33ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81621286
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69711657
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67898228
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.63675896
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60449741
38* GABP_19822575_ChIP-Seq_HepG2_Human1.60159145
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55216824
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54374421
41MYC_18940864_ChIP-ChIP_HL60_Human1.53590529
42IRF1_19129219_ChIP-ChIP_H3396_Human1.51754232
43AR_21909140_ChIP-Seq_LNCAP_Human1.51051777
44* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49167779
45TAF15_26573619_Chip-Seq_HEK293_Human1.44436393
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33805610
47VDR_22108803_ChIP-Seq_LS180_Human1.30629645
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29042633
49* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28204570
50CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.28195825
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.28011818
52NANOG_16153702_ChIP-ChIP_HESCs_Human1.26136602
53* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25782501
54* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23083645
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22904977
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21600937
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.21575426
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19053397
59ZNF274_21170338_ChIP-Seq_K562_Hela1.17147238
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16635732
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14048359
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12434231
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11930242
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11921503
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10591947
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08590149
67SOX17_20123909_ChIP-Seq_XEN_Mouse1.06666300
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02699591
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02401307
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.01761852
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01424341
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00424092
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97389295
74FUS_26573619_Chip-Seq_HEK293_Human0.96448047
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95633926
76* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95308577
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95196859
78ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94604178
79FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94097227
80P300_19829295_ChIP-Seq_ESCs_Human0.93061644
81SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91933018
82SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91084659
83MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90688520
84CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88092384
85FLI1_27457419_Chip-Seq_LIVER_Mouse0.87848102
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86504638
87NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86380027
88EWS_26573619_Chip-Seq_HEK293_Human0.86132032
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85793440
90E2F7_22180533_ChIP-Seq_HELA_Human0.85435493
91TP53_22573176_ChIP-Seq_HFKS_Human0.85128215
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84487562
93POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83910533
94RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83796990
95ER_23166858_ChIP-Seq_MCF-7_Human0.81603190
96* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81014159
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80825969
98* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80012909
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.78705503
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78465864
101ELF5_23300383_ChIP-Seq_T47D_Human0.77654611
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76086871
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.76051860
104IRF8_21731497_ChIP-ChIP_J774_Mouse0.73957743
105ZFX_18555785_ChIP-Seq_MESCs_Mouse0.73066720
106HTT_18923047_ChIP-ChIP_STHdh_Human0.72485267
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.72442322
108NFE2_27457419_Chip-Seq_LIVER_Mouse0.72359815
109EZH2_27294783_Chip-Seq_NPCs_Mouse0.71447942
110GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71400256
111NANOG_19829295_ChIP-Seq_ESCs_Human0.70760820
112MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.70218650
113* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.68099638
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.67520648
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.67269112
116KDM5A_27292631_Chip-Seq_BREAST_Human0.67268822
117* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66834427
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.66523842
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.64070112
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.63959843
121CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.62862557

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.15825990
2MP0003880_abnormal_central_pattern4.16926958
3MP0001529_abnormal_vocalization3.88545338
4MP0002139_abnormal_hepatobiliary_system3.28989952
5MP0001905_abnormal_dopamine_level2.95511668
6MP0003806_abnormal_nucleotide_metabolis2.62261505
7MP0006276_abnormal_autonomic_nervous2.60847017
8MP0003941_abnormal_skin_development2.57170419
9MP0003718_maternal_effect2.55365348
10MP0006072_abnormal_retinal_apoptosis2.45873128
11MP0003136_yellow_coat_color2.41121951
12MP0003186_abnormal_redox_activity2.33095461
13MP0003111_abnormal_nucleus_morphology2.30490242
14MP0003693_abnormal_embryo_hatching2.08319686
15MP0004142_abnormal_muscle_tone2.03687683
16MP0004957_abnormal_blastocyst_morpholog1.97694685
17MP0006035_abnormal_mitochondrial_morpho1.92633914
18MP0001188_hyperpigmentation1.92033440
19MP0000372_irregular_coat_pigmentation1.85774697
20MP0005408_hypopigmentation1.83272513
21MP0008007_abnormal_cellular_replicative1.83139668
22MP0004147_increased_porphyrin_level1.80649548
23MP0001853_heart_inflammation1.77880309
24MP0008932_abnormal_embryonic_tissue1.76163744
25MP0002736_abnormal_nociception_after1.76017411
26MP0003724_increased_susceptibility_to1.74493699
27MP0002163_abnormal_gland_morphology1.68827131
28MP0005409_darkened_coat_color1.68767157
29MP0001968_abnormal_touch/_nociception1.67500737
30MP0004381_abnormal_hair_follicle1.66312893
31MP0006036_abnormal_mitochondrial_physio1.64748012
32MP0001293_anophthalmia1.63356008
33MP0002638_abnormal_pupillary_reflex1.59389865
34MP0002876_abnormal_thyroid_physiology1.48784016
35MP0009697_abnormal_copulation1.47688936
36MP0001727_abnormal_embryo_implantation1.44916375
37MP0001440_abnormal_grooming_behavior1.41334061
38MP0006054_spinal_hemorrhage1.35925122
39MP0008877_abnormal_DNA_methylation1.35142777
40MP0003786_premature_aging1.34827951
41MP0002148_abnormal_hypersensitivity_rea1.33038458
42MP0001542_abnormal_bone_strength1.32941111
43MP0002277_abnormal_respiratory_mucosa1.32119123
44MP0005253_abnormal_eye_physiology1.31967539
45MP0004215_abnormal_myocardial_fiber1.31752431
46MP0003890_abnormal_embryonic-extraembry1.29353910
47MP0010030_abnormal_orbit_morphology1.29319559
48MP0002102_abnormal_ear_morphology1.29030563
49MP0003195_calcinosis1.27404140
50MP0002090_abnormal_vision1.26511346
51MP0001764_abnormal_homeostasis1.26399206
52MP0008260_abnormal_autophagy1.25814799
53MP0009333_abnormal_splenocyte_physiolog1.24478355
54MP0005379_endocrine/exocrine_gland_phen1.22906190
55MP0003329_amyloid_beta_deposits1.17310382
56MP0003011_delayed_dark_adaptation1.16233503
57MP0001485_abnormal_pinna_reflex1.16004815
58MP0002751_abnormal_autonomic_nervous1.15705232
59MP0009785_altered_susceptibility_to1.15561389
60MP0003191_abnormal_cellular_cholesterol1.15516568
61MP0002938_white_spotting1.15034660
62MP0003567_abnormal_fetal_cardiomyocyte1.14927048
63MP0001986_abnormal_taste_sensitivity1.14290470
64MP0003950_abnormal_plasma_membrane1.12879994
65MP0003315_abnormal_perineum_morphology1.10066079
66MP0008058_abnormal_DNA_repair1.08385306
67MP0006292_abnormal_olfactory_placode1.07926725
68MP0002095_abnormal_skin_pigmentation1.07925181
69MP0005084_abnormal_gallbladder_morpholo1.07237450
70MP0005171_absent_coat_pigmentation1.06995254
71MP0008057_abnormal_DNA_replication1.06128938
72MP0002734_abnormal_mechanical_nocicepti1.05766445
73MP0002272_abnormal_nervous_system1.05215356
74MP0002132_abnormal_respiratory_system1.04610918
75MP0008995_early_reproductive_senescence1.04422390
76MP0009745_abnormal_behavioral_response1.04170973
77MP0002064_seizures1.03529885
78MP0009046_muscle_twitch1.03206556
79MP0005423_abnormal_somatic_nervous1.01160576
80MP0001970_abnormal_pain_threshold0.98652706
81MP0002282_abnormal_trachea_morphology0.96675900
82MP0005075_abnormal_melanosome_morpholog0.94815014
83MP0000516_abnormal_urinary_system0.94425931
84MP0005367_renal/urinary_system_phenotyp0.94425931
85MP0002210_abnormal_sex_determination0.93724468
86MP0008875_abnormal_xenobiotic_pharmacok0.93420213
87MP0003937_abnormal_limbs/digits/tail_de0.92931163
88MP0005551_abnormal_eye_electrophysiolog0.91945850
89MP0004742_abnormal_vestibular_system0.91104131
90MP0000647_abnormal_sebaceous_gland0.89611739
91MP0000566_synostosis0.88944194
92MP0002733_abnormal_thermal_nociception0.88321961
93MP0001835_abnormal_antigen_presentation0.86292397
94MP0002735_abnormal_chemical_nociception0.86139850
95MP0005025_abnormal_response_to0.85524507
96MP0000350_abnormal_cell_proliferation0.84641733
97MP0002837_dystrophic_cardiac_calcinosis0.84580239
98MP0005671_abnormal_response_to0.84548035
99MP0001697_abnormal_embryo_size0.83572565
100MP0005332_abnormal_amino_acid0.83038478
101MP0001984_abnormal_olfaction0.82946606
102MP0004133_heterotaxia0.82743131
103MP0005636_abnormal_mineral_homeostasis0.82355253
104MP0002184_abnormal_innervation0.82250066
105MP0008789_abnormal_olfactory_epithelium0.81990383
106MP0006082_CNS_inflammation0.80945782
107MP0005376_homeostasis/metabolism_phenot0.80459112
108MP0002233_abnormal_nose_morphology0.80445153
109MP0002067_abnormal_sensory_capabilities0.80259629
110MP0001286_abnormal_eye_development0.79778129
111MP0005499_abnormal_olfactory_system0.79325460
112MP0005394_taste/olfaction_phenotype0.79325460
113MP0003077_abnormal_cell_cycle0.79291807
114MP0000631_abnormal_neuroendocrine_gland0.78897553
115MP0010386_abnormal_urinary_bladder0.78172599
116MP0002572_abnormal_emotion/affect_behav0.77366777
117MP0000049_abnormal_middle_ear0.76761255
118MP0004924_abnormal_behavior0.75414689
119MP0005386_behavior/neurological_phenoty0.75414689
120MP0002160_abnormal_reproductive_system0.74672597
121MP0000653_abnormal_sex_gland0.74665792
122MP0000026_abnormal_inner_ear0.73950379
123MP0001929_abnormal_gametogenesis0.72813043
124MP0005164_abnormal_response_to0.72366914
125MP0005389_reproductive_system_phenotype0.71672390
126MP0005395_other_phenotype0.71579714
127MP0001730_embryonic_growth_arrest0.71263949
128MP0001145_abnormal_male_reproductive0.71219978
129MP0002822_catalepsy0.70849344
130MP0008872_abnormal_physiological_respon0.70643816
131MP0003119_abnormal_digestive_system0.69985990
132MP0003137_abnormal_impulse_conducting0.69731791
133MP0002254_reproductive_system_inflammat0.69496970
134MP0002085_abnormal_embryonic_tissue0.68433332
135MP0000920_abnormal_myelination0.68337164
136MP0008004_abnormal_stomach_pH0.68198145
137MP0002332_abnormal_exercise_endurance0.68180629
138MP0002234_abnormal_pharynx_morphology0.68171843
139MP0010094_abnormal_chromosome_stability0.67803210
140MP0004883_abnormal_blood_vessel0.67757269
141MP0001919_abnormal_reproductive_system0.67317694
142MP0009250_abnormal_appendicular_skeleto0.66872063
143MP0008469_abnormal_protein_level0.66321930
144MP0000604_amyloidosis0.65734391
145MP0001963_abnormal_hearing_physiology0.65719030
146MP0000313_abnormal_cell_death0.65463330
147MP0004270_analgesia0.65308307
148MP0005391_vision/eye_phenotype0.64727580
149MP0000358_abnormal_cell_content/0.63387998
150MP0005000_abnormal_immune_tolerance0.62873343
151MP0003122_maternal_imprinting0.62861612
152MP0001486_abnormal_startle_reflex0.62843884
153MP0004145_abnormal_muscle_electrophysio0.62349601

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.54569078
2Mitochondrial inheritance (HP:0001427)6.05105331
3Abnormal mitochondria in muscle tissue (HP:0008316)5.80327400
4Increased hepatocellular lipid droplets (HP:0006565)5.58983234
5Progressive macrocephaly (HP:0004481)5.45675292
6Acute encephalopathy (HP:0006846)5.28867563
7Hepatocellular necrosis (HP:0001404)5.14246936
8Increased CSF lactate (HP:0002490)5.12916132
9Renal Fanconi syndrome (HP:0001994)4.95178634
10Lipid accumulation in hepatocytes (HP:0006561)4.93572715
11Abnormality of cells of the erythroid lineage (HP:0012130)4.83811738
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.67687595
13Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.38987874
14Hepatic necrosis (HP:0002605)4.37638535
153-Methylglutaconic aciduria (HP:0003535)4.27738740
16Increased serum pyruvate (HP:0003542)4.27701429
17Abnormality of glycolysis (HP:0004366)4.27701429
18Abnormal number of erythroid precursors (HP:0012131)4.24187599
19Exertional dyspnea (HP:0002875)3.92918133
20Cerebral edema (HP:0002181)3.92508024
21Macrocytic anemia (HP:0001972)3.92374713
22Increased intramyocellular lipid droplets (HP:0012240)3.89746714
23Reticulocytopenia (HP:0001896)3.85897998
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.70622452
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.70622452
26Exercise intolerance (HP:0003546)3.58838295
27Respiratory failure (HP:0002878)3.56114110
28Increased serum lactate (HP:0002151)3.52709672
29Optic disc pallor (HP:0000543)3.46699531
30Lactic acidosis (HP:0003128)3.27181265
31Leukodystrophy (HP:0002415)3.18940458
32Increased muscle lipid content (HP:0009058)3.17820199
33Respiratory difficulties (HP:0002880)3.15351450
34Pallor (HP:0000980)3.11781483
35Abnormality of renal resorption (HP:0011038)3.09605911
36Methylmalonic acidemia (HP:0002912)2.94076559
37* Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.66760620
38Hyperphosphaturia (HP:0003109)2.64066763
39Abnormality of methionine metabolism (HP:0010901)2.62807751
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.53558122
41Abnormality of alanine metabolism (HP:0010916)2.53558122
42Hyperalaninemia (HP:0003348)2.53558122
43CNS demyelination (HP:0007305)2.48476417
44Congenital, generalized hypertrichosis (HP:0004540)2.46229649
45Colon cancer (HP:0003003)2.41935423
46Degeneration of anterior horn cells (HP:0002398)2.39944399
47Abnormality of the anterior horn cell (HP:0006802)2.39944399
48Abnormality of the axillary hair (HP:0100134)2.37626772
49Abnormality of secondary sexual hair (HP:0009888)2.37626772
50Cerebral hypomyelination (HP:0006808)2.35311715
51Abnormality of serum amino acid levels (HP:0003112)2.34907972
52Generalized aminoaciduria (HP:0002909)2.29798346
53Breast hypoplasia (HP:0003187)2.25464327
54Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25364731
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23788603
56Reduced antithrombin III activity (HP:0001976)2.22458886
57Meckel diverticulum (HP:0002245)2.17460243
58Microvesicular hepatic steatosis (HP:0001414)2.16643646
59Emotional lability (HP:0000712)2.16526400
60Glycosuria (HP:0003076)2.16391543
61Abnormality of urine glucose concentration (HP:0011016)2.16391543
62Septo-optic dysplasia (HP:0100842)2.14872298
63Lethargy (HP:0001254)2.14733075
64Abnormal protein glycosylation (HP:0012346)2.14494679
65Abnormal glycosylation (HP:0012345)2.14494679
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14494679
67Abnormal protein N-linked glycosylation (HP:0012347)2.14494679
68Abnormal pupillary function (HP:0007686)2.13065327
69Megaloblastic anemia (HP:0001889)2.10890434
70X-linked dominant inheritance (HP:0001423)2.09312953
71Abnormal urine phosphate concentration (HP:0012599)2.08709352
72Abnormal hemoglobin (HP:0011902)2.05408542
73* Congenital ichthyosiform erythroderma (HP:0007431)2.04758210
74Abnormality of the ileum (HP:0001549)2.03543604
75Type I transferrin isoform profile (HP:0003642)1.99988891
76Oral leukoplakia (HP:0002745)1.99665318
77Delusions (HP:0000746)1.93820558
78Hyperglycinemia (HP:0002154)1.92743027
79Molar tooth sign on MRI (HP:0002419)1.92707385
80Abnormality of midbrain morphology (HP:0002418)1.92707385
81Abnormality of the labia minora (HP:0012880)1.92508161
82Pancreatic cysts (HP:0001737)1.90760769
83Pancreatic fibrosis (HP:0100732)1.89338374
84Aplasia/Hypoplasia of the uvula (HP:0010293)1.88237459
85Birth length less than 3rd percentile (HP:0003561)1.86682033
86Abnormal lung lobation (HP:0002101)1.86372794
87Renal tubular dysfunction (HP:0000124)1.83831179
88Nausea (HP:0002018)1.82576216
89Severe combined immunodeficiency (HP:0004430)1.81849328
90Hypothermia (HP:0002045)1.81501697
91Absent septum pellucidum (HP:0001331)1.80904375
92Progressive external ophthalmoplegia (HP:0000590)1.79176091
93Sensory axonal neuropathy (HP:0003390)1.77741734
94* Parakeratosis (HP:0001036)1.76767129
95Secondary amenorrhea (HP:0000869)1.75823183
96Blindness (HP:0000618)1.75439587
97Rough bone trabeculation (HP:0100670)1.75348544
98Abnormality of chromosome stability (HP:0003220)1.75012584
99Nasolacrimal duct obstruction (HP:0000579)1.73756208
100Type 2 muscle fiber atrophy (HP:0003554)1.72136678
101Abnormality of the preputium (HP:0100587)1.70281571
102Medial flaring of the eyebrow (HP:0010747)1.69628950
103True hermaphroditism (HP:0010459)1.69386028
104Aplastic anemia (HP:0001915)1.68928900
105Multiple enchondromatosis (HP:0005701)1.68222639
106Abnormality of the vitamin B12 metabolism (HP:0004341)1.67846434
107Erythroderma (HP:0001019)1.67711955
108Aplasia/hypoplasia of the uterus (HP:0008684)1.67498162
109Poor suck (HP:0002033)1.65630717
110Gliosis (HP:0002171)1.65475523
111Concave nail (HP:0001598)1.63210830
112Abnormality of vitamin B metabolism (HP:0004340)1.62908426
113Limb dystonia (HP:0002451)1.62756738
114Autoamputation (HP:0001218)1.62018650
115Triphalangeal thumb (HP:0001199)1.61965560
116Abnormality of the septum pellucidum (HP:0007375)1.61788098
117Aplasia/Hypoplasia involving the musculature (HP:0001460)1.61745205
118Sparse eyelashes (HP:0000653)1.61172928
119CNS hypomyelination (HP:0003429)1.60331326
120Increased IgM level (HP:0003496)1.59808358
121Stenosis of the external auditory canal (HP:0000402)1.58690945
122Muscle fiber atrophy (HP:0100295)1.58495979
123Short tibia (HP:0005736)1.56892652
124Dicarboxylic aciduria (HP:0003215)1.56708870
125Abnormality of dicarboxylic acid metabolism (HP:0010995)1.56708870
126Absent thumb (HP:0009777)1.56080487
127Hypobetalipoproteinemia (HP:0003563)1.54441396
128Cerebral hemorrhage (HP:0001342)1.52279341
129Abnormal respiratory epithelium morphology (HP:0012253)1.50059589
130Abnormal respiratory motile cilium morphology (HP:0005938)1.50059589
131Hypokinesia (HP:0002375)1.49412652
132Irregular epiphyses (HP:0010582)1.46761498
133Dry hair (HP:0011359)1.45999448
134Abnormal autonomic nervous system physiology (HP:0012332)1.45723192
135Methylmalonic aciduria (HP:0012120)1.44700201
136Neuroendocrine neoplasm (HP:0100634)1.42238935
137Combined immunodeficiency (HP:0005387)1.42120509
138Pancytopenia (HP:0001876)1.41525052
139Hepatosplenomegaly (HP:0001433)1.41032519
140Postnatal microcephaly (HP:0005484)1.40133875
141Abnormal trabecular bone morphology (HP:0100671)1.40115788
142Cellular immunodeficiency (HP:0005374)1.39595807

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.44225497
2STK163.48876536
3BUB13.30974873
4NME23.29067327
5NME13.25579446
6PBK2.91288276
7MAP3K122.88454058
8NEK12.87404758
9MST42.85049666
10EIF2AK12.82319727
11MUSK2.54532313
12WEE12.24962119
13TLK12.22858182
14VRK12.17341331
15PIM21.99992833
16TESK21.98407298
17EIF2AK31.96166197
18PNCK1.93549980
19GRK71.90453384
20CASK1.88578537
21SRPK11.83356947
22TRIM281.77068245
23NUAK11.76320357
24TSSK61.72187954
25TAF11.68900028
26KDR1.65904242
27CDK191.65580365
28TTK1.63348355
29LIMK11.58599641
30ARAF1.56386164
31WNK31.54799157
32BMPR1B1.53787216
33PDK21.48621646
34BCR1.44728462
35MKNK11.39007197
36STK391.36899494
37MAP4K21.23053744
38DYRK21.18679024
39PLK41.14968214
40ADRBK21.14938920
41MYLK1.12651694
42ABL21.12151285
43OXSR11.09551018
44MKNK21.06021808
45IRAK41.00215040
46EIF2AK20.99161047
47PAK40.99009115
48BLK0.96301807
49BMPR20.93621368
50MAPKAPK50.93160113
51IRAK30.92938203
52GRK50.92034689
53BCKDK0.91979800
54MAP2K70.91461383
55PLK20.90822480
56AURKA0.89583072
57MAP3K110.88956285
58PLK30.88614860
59CSNK1G30.86984120
60TIE10.81274954
61CSNK2A10.77262438
62IKBKB0.75311779
63BRAF0.75224357
64CHEK20.74114465
65INSRR0.73825871
66ERBB30.73103189
67TNIK0.69532997
68CSNK2A20.67540654
69RPS6KA50.67402126
70CSNK1G10.66809763
71ZAK0.65272924
72DYRK30.64916165
73MARK10.62792065
74CAMK2B0.61930522
75ADRBK10.60455904
76ACVR1B0.57116427
77DAPK10.57096966
78FGR0.56758833
79ATR0.56642227
80STK38L0.55856019
81CCNB10.55523373
82ILK0.54561663
83CSNK1A1L0.53321857
84TXK0.52905147
85NEK20.52591180
86GRK10.50743392
87ERBB40.50264787
88EPHA20.50242131
89RIPK40.50209766
90TESK10.49293419
91PLK10.49141779
92YES10.48717081
93BRSK10.48064790
94PAK10.47246392
95STK30.46927921
96DAPK30.46596089
97TGFBR10.46449760
98IRAK10.46353108
99CDK80.45674396
100CAMK2A0.44851472
101RPS6KA40.43107451
102UHMK10.42534355
103STK240.42301417
104STK40.42154977
105CDK140.41953049
106PRKCG0.40997075
107CAMK2G0.40528971
108SYK0.39471317
109MAPK40.39108310
110MINK10.38790819
111ALK0.38765865
112WNK40.37779573
113MAPK130.37645792
114AURKB0.37035067
115IRAK20.37014452
116LYN0.36791337
117PRKCE0.36260722
118BRSK20.35773759
119CAMK2D0.35403819
120FES0.35119330
121OBSCN0.34847299
122MAP3K40.34780398
123ROCK20.34766022
124MST1R0.33558445
125CSNK1A10.33527275
126PIK3CG0.33289668
127ATM0.33062520
128CSNK1E0.32958255
129EPHB20.32290003
130CDK30.32083860
131AKT30.29471986
132CSNK1G20.29110943
133CDC70.28776678
134PASK0.28455314
135CDK11A0.27959501
136CDK180.27771779
137FGFR10.26979238
138CHEK10.26303857

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.57877211
2Oxidative phosphorylation_Homo sapiens_hsa001905.32370413
3* Proteasome_Homo sapiens_hsa030505.27275002
4Parkinsons disease_Homo sapiens_hsa050124.45467742
5RNA polymerase_Homo sapiens_hsa030203.50117033
6Alzheimers disease_Homo sapiens_hsa050103.25387676
7Huntingtons disease_Homo sapiens_hsa050163.24873206
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.86513442
9Protein export_Homo sapiens_hsa030602.77010089
10Pyrimidine metabolism_Homo sapiens_hsa002402.07492405
11Spliceosome_Homo sapiens_hsa030401.92036791
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85526055
13DNA replication_Homo sapiens_hsa030301.84045294
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81652961
15Nucleotide excision repair_Homo sapiens_hsa034201.57035360
16Mismatch repair_Homo sapiens_hsa034301.56616961
17Cardiac muscle contraction_Homo sapiens_hsa042601.53633658
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52825551
19Collecting duct acid secretion_Homo sapiens_hsa049661.44291919
20Fatty acid elongation_Homo sapiens_hsa000621.42707925
21Homologous recombination_Homo sapiens_hsa034401.39095122
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37827489
23Propanoate metabolism_Homo sapiens_hsa006401.31692735
24Basal transcription factors_Homo sapiens_hsa030221.21971817
25Steroid biosynthesis_Homo sapiens_hsa001001.16599249
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10303883
27RNA transport_Homo sapiens_hsa030131.09998323
28Purine metabolism_Homo sapiens_hsa002301.08850678
29Base excision repair_Homo sapiens_hsa034100.95646852
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95617000
31Vibrio cholerae infection_Homo sapiens_hsa051100.89414296
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88687639
33SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87758574
34Glutathione metabolism_Homo sapiens_hsa004800.87639190
35Rheumatoid arthritis_Homo sapiens_hsa053230.86617728
36Metabolic pathways_Homo sapiens_hsa011000.80216170
37Folate biosynthesis_Homo sapiens_hsa007900.78232583
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77443470
39Tyrosine metabolism_Homo sapiens_hsa003500.77231361
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76965930
41Selenocompound metabolism_Homo sapiens_hsa004500.75943762
42RNA degradation_Homo sapiens_hsa030180.70970902
43Epstein-Barr virus infection_Homo sapiens_hsa051690.68148202
44Phenylalanine metabolism_Homo sapiens_hsa003600.67511005
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65946727
46Arachidonic acid metabolism_Homo sapiens_hsa005900.65682268
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65448315
48Graft-versus-host disease_Homo sapiens_hsa053320.63720510
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63432568
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63059445
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.62914957
52Phagosome_Homo sapiens_hsa041450.61910760
53Allograft rejection_Homo sapiens_hsa053300.60067325
54Non-homologous end-joining_Homo sapiens_hsa034500.58548655
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55979713
56Nicotine addiction_Homo sapiens_hsa050330.55872352
57Butanoate metabolism_Homo sapiens_hsa006500.55872265
58Sulfur relay system_Homo sapiens_hsa041220.55552487
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55264926
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54975944
61Asthma_Homo sapiens_hsa053100.52890780
62Ether lipid metabolism_Homo sapiens_hsa005650.51768287
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51324889
64Autoimmune thyroid disease_Homo sapiens_hsa053200.51154616
65Tryptophan metabolism_Homo sapiens_hsa003800.50854541
66Fanconi anemia pathway_Homo sapiens_hsa034600.50185745
67One carbon pool by folate_Homo sapiens_hsa006700.50104319
68Oocyte meiosis_Homo sapiens_hsa041140.49124790
69Histidine metabolism_Homo sapiens_hsa003400.48515165
70Phototransduction_Homo sapiens_hsa047440.48348810
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.47736009
72mRNA surveillance pathway_Homo sapiens_hsa030150.46984025
73Chemical carcinogenesis_Homo sapiens_hsa052040.46915634
74Sphingolipid metabolism_Homo sapiens_hsa006000.46380208
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46339275
76Sulfur metabolism_Homo sapiens_hsa009200.44914614
77Caffeine metabolism_Homo sapiens_hsa002320.44818726
78Pyruvate metabolism_Homo sapiens_hsa006200.44121482
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42680467
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42108881
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41707328
82Vitamin digestion and absorption_Homo sapiens_hsa049770.41294628
83Nitrogen metabolism_Homo sapiens_hsa009100.40640469
84Serotonergic synapse_Homo sapiens_hsa047260.39828002
85Linoleic acid metabolism_Homo sapiens_hsa005910.38510446
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37831886
87Regulation of autophagy_Homo sapiens_hsa041400.37579953
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36868568
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36663850
90Biosynthesis of amino acids_Homo sapiens_hsa012300.36124001
91Vitamin B6 metabolism_Homo sapiens_hsa007500.35718636
92Arginine and proline metabolism_Homo sapiens_hsa003300.35287046
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.34817605
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.34632919
95Fatty acid degradation_Homo sapiens_hsa000710.32575074
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32496990
97N-Glycan biosynthesis_Homo sapiens_hsa005100.29255064
98Pentose phosphate pathway_Homo sapiens_hsa000300.29246291
99Mineral absorption_Homo sapiens_hsa049780.27542696
100Systemic lupus erythematosus_Homo sapiens_hsa053220.27335503
101Peroxisome_Homo sapiens_hsa041460.26983004
102Synaptic vesicle cycle_Homo sapiens_hsa047210.26711306
103Cell cycle_Homo sapiens_hsa041100.25940491
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25932483
105Retinol metabolism_Homo sapiens_hsa008300.25312128
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23498029
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.23022409
108Fatty acid metabolism_Homo sapiens_hsa012120.22891302
109Pertussis_Homo sapiens_hsa051330.21872183
110Type I diabetes mellitus_Homo sapiens_hsa049400.21500916
111Carbon metabolism_Homo sapiens_hsa012000.21172501
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18762087
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18226330
114African trypanosomiasis_Homo sapiens_hsa051430.17934509
115TGF-beta signaling pathway_Homo sapiens_hsa043500.17775156
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17715139
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.17264574
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16710749
119Primary immunodeficiency_Homo sapiens_hsa053400.16228805
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15737677
121beta-Alanine metabolism_Homo sapiens_hsa004100.13372382
122p53 signaling pathway_Homo sapiens_hsa041150.13055248
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.12855326
124Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.12582409
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12070129
126Fat digestion and absorption_Homo sapiens_hsa049750.11148121

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