PON3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug catabolic process (GO:0042737)8.32421857
2exogenous drug catabolic process (GO:0042738)8.31494823
3epoxygenase P450 pathway (GO:0019373)8.06996420
4omega-hydroxylase P450 pathway (GO:0097267)7.75266922
5oxidative demethylation (GO:0070989)6.07618288
6drug metabolic process (GO:0017144)6.03864640
7blood coagulation, intrinsic pathway (GO:0007597)5.53918179
8glucuronate metabolic process (GO:0019585)5.38171690
9uronic acid metabolic process (GO:0006063)5.38171690
10serine family amino acid catabolic process (GO:0009071)5.35621942
11cellular glucuronidation (GO:0052695)5.27522674
12negative regulation of protein activation cascade (GO:2000258)4.90123107
13* phenylpropanoid metabolic process (GO:0009698)4.88334889
14S-adenosylmethionine metabolic process (GO:0046500)4.66377303
15glycine metabolic process (GO:0006544)4.59111365
16cellular ketone body metabolic process (GO:0046950)4.56598930
17negative regulation of cholesterol transport (GO:0032375)4.55323362
18negative regulation of sterol transport (GO:0032372)4.55323362
19regulation of plasminogen activation (GO:0010755)4.50523136
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.43605507
21L-phenylalanine catabolic process (GO:0006559)4.43605507
22negative regulation of complement activation (GO:0045916)4.32024553
23sulfur amino acid catabolic process (GO:0000098)4.30267113
24imidazole-containing compound metabolic process (GO:0052803)4.24652658
25regulation of humoral immune response (GO:0002920)4.21544781
26L-phenylalanine metabolic process (GO:0006558)4.20874494
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.20874494
28alkaloid metabolic process (GO:0009820)4.19484235
29negative regulation of blood coagulation (GO:0030195)4.17235547
30negative regulation of hemostasis (GO:1900047)4.17235547
31triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.16360534
32bile acid biosynthetic process (GO:0006699)4.13175632
33aromatic amino acid family catabolic process (GO:0009074)4.12711767
34aldehyde catabolic process (GO:0046185)4.08738696
35complement activation, alternative pathway (GO:0006957)4.07818844
36response to nitrosative stress (GO:0051409)4.07083945
37arginine metabolic process (GO:0006525)4.03311400
38ketone body metabolic process (GO:1902224)4.02815102
39peptidyl-glutamic acid carboxylation (GO:0017187)4.01224368
40protein carboxylation (GO:0018214)4.01224368
41* xenobiotic catabolic process (GO:0042178)3.96318656
42alpha-amino acid catabolic process (GO:1901606)3.95728945
43indole-containing compound catabolic process (GO:0042436)3.91548189
44indolalkylamine catabolic process (GO:0046218)3.91548189
45tryptophan catabolic process (GO:0006569)3.91548189
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.90655871
47tryptophan metabolic process (GO:0006568)3.89949988
48glyoxylate metabolic process (GO:0046487)3.86749026
49serine family amino acid metabolic process (GO:0009069)3.84643579
50negative regulation of coagulation (GO:0050819)3.82380888
51negative regulation of wound healing (GO:0061045)3.81350890
52alpha-linolenic acid metabolic process (GO:0036109)3.79024695
53cytolysis (GO:0019835)3.76063599
54glutamate metabolic process (GO:0006536)3.72271276
55heme transport (GO:0015886)3.70868939
56high-density lipoprotein particle remodeling (GO:0034375)3.70054230
57regulation of protein activation cascade (GO:2000257)3.67739782
58hormone catabolic process (GO:0042447)3.65543612
59regulation of triglyceride catabolic process (GO:0010896)3.64697364
60urea metabolic process (GO:0019627)3.63659491
61urea cycle (GO:0000050)3.63659491
62complement activation, classical pathway (GO:0006958)3.62350682
63daunorubicin metabolic process (GO:0044597)3.56130439
64polyketide metabolic process (GO:0030638)3.56130439
65doxorubicin metabolic process (GO:0044598)3.56130439
66kynurenine metabolic process (GO:0070189)3.54354137
67intestinal cholesterol absorption (GO:0030299)3.52661069
68regulation of complement activation (GO:0030449)3.51739580
69cellular amino acid catabolic process (GO:0009063)3.50680511
70cysteine metabolic process (GO:0006534)3.49945743
71complement activation (GO:0006956)3.49715682
72* xenobiotic metabolic process (GO:0006805)3.48210770
73bile acid metabolic process (GO:0008206)3.47481598
74phospholipid efflux (GO:0033700)3.43466257
75valine metabolic process (GO:0006573)3.42075332
76plasma lipoprotein particle clearance (GO:0034381)3.41884609
77amino-acid betaine metabolic process (GO:0006577)3.39376346
78reverse cholesterol transport (GO:0043691)3.38620610
79steroid catabolic process (GO:0006706)3.38001615
80disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.37821849
81killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.37821849
82negative regulation of lipase activity (GO:0060192)3.34610073
83hydrogen peroxide biosynthetic process (GO:0050665)3.32406979
84nitrogen cycle metabolic process (GO:0071941)3.32371159
85acute inflammatory response (GO:0002526)3.31546353
86regulation of cholesterol esterification (GO:0010872)3.30627690
87fatty acid beta-oxidation (GO:0006635)3.30337407
88negative regulation of fibrinolysis (GO:0051918)3.30101571
89plasma lipoprotein particle remodeling (GO:0034369)3.27274065
90protein-lipid complex remodeling (GO:0034368)3.27274065
91macromolecular complex remodeling (GO:0034367)3.27274065
92ethanol oxidation (GO:0006069)3.26598856
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.26129288
94fatty acid oxidation (GO:0019395)3.25833321
95protein activation cascade (GO:0072376)3.23303795
96regulation of fibrinolysis (GO:0051917)3.22595275
97lipid oxidation (GO:0034440)3.21698891
98* benzene-containing compound metabolic process (GO:0042537)3.19907601
99positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.18761045
100homocysteine metabolic process (GO:0050667)3.15933425
101flavonoid metabolic process (GO:0009812)3.14819572
102tyrosine metabolic process (GO:0006570)3.13389478
103positive regulation of lipid catabolic process (GO:0050996)3.10891615
104acylglycerol homeostasis (GO:0055090)3.10816810
105triglyceride homeostasis (GO:0070328)3.10816810
106cholesterol efflux (GO:0033344)3.09302896
107carnitine metabolic process (GO:0009437)3.06956901
108regulation of cholesterol biosynthetic process (GO:0045540)3.05119175
109reactive oxygen species biosynthetic process (GO:1903409)3.03266341
110phospholipid homeostasis (GO:0055091)3.03203760
111fatty acid catabolic process (GO:0009062)3.01969496
112low-density lipoprotein particle remodeling (GO:0034374)2.99321019
113bile acid and bile salt transport (GO:0015721)2.99210148
114regulation of cholesterol metabolic process (GO:0090181)2.98990175
115acute-phase response (GO:0006953)2.96637669
116fibrinolysis (GO:0042730)2.96576825
117* monocarboxylic acid catabolic process (GO:0072329)2.96192561
118aromatic amino acid family metabolic process (GO:0009072)2.96157251
119L-ascorbic acid metabolic process (GO:0019852)2.88034064
120primary alcohol catabolic process (GO:0034310)2.87639047
121positive regulation of triglyceride lipase activity (GO:0061365)2.86835678
122positive regulation of lipoprotein lipase activity (GO:0051006)2.86835678
123positive regulation of coagulation (GO:0050820)2.86618549
124indolalkylamine metabolic process (GO:0006586)2.85901487
125cellular biogenic amine catabolic process (GO:0042402)2.84243885
126amine catabolic process (GO:0009310)2.84243885
127ethanol metabolic process (GO:0006067)2.83185177
128positive regulation of hemostasis (GO:1900048)2.82118373
129positive regulation of blood coagulation (GO:0030194)2.82118373
130positive regulation of sterol transport (GO:0032373)2.80820880
131positive regulation of cholesterol transport (GO:0032376)2.80820880
132negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.80303792
133plasma lipoprotein particle assembly (GO:0034377)2.79966102
134cofactor catabolic process (GO:0051187)2.78953517
135glutathione derivative metabolic process (GO:1901685)2.77616966
136glutathione derivative biosynthetic process (GO:1901687)2.77616966
137negative regulation of lipid storage (GO:0010888)2.77533876
138regulation of sequestering of triglyceride (GO:0010889)2.74596367
139regulation of cholesterol storage (GO:0010885)2.73754468
140plasma lipoprotein particle organization (GO:0071827)2.73139359
141opsonization (GO:0008228)2.72283183
142very-low-density lipoprotein particle assembly (GO:0034379)2.71287273

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.58087650
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.47018111
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.93378003
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.79606658
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.71686667
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.48814399
7IRF8_22096565_ChIP-ChIP_GC-B_Human4.27618890
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.59436520
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.55134413
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.38379552
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.93949657
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.69641986
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.68520398
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.62894029
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.60284815
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.57233719
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.35303323
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27833747
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.26522770
20GATA1_22025678_ChIP-Seq_K562_Human2.19833201
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14214707
22IGF1R_20145208_ChIP-Seq_DFB_Human2.11961132
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.10958468
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08246685
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.07149268
26HTT_18923047_ChIP-ChIP_STHdh_Human2.07045301
27GBX2_23144817_ChIP-Seq_PC3_Human2.01448170
28* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01158123
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.98198945
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95227049
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93987551
32CLOCK_20551151_ChIP-Seq_293T_Human1.91298375
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89773168
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86017869
35BCAT_22108803_ChIP-Seq_LS180_Human1.70829079
36VDR_22108803_ChIP-Seq_LS180_Human1.69040002
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65821884
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.64134099
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59935757
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59298026
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.59201800
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.56351079
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53307953
44* ER_23166858_ChIP-Seq_MCF-7_Human1.53034479
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50418443
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.49399193
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49074001
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48027912
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48027912
50TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.43387064
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.41856365
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41519827
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39083781
54ZNF274_21170338_ChIP-Seq_K562_Hela1.38564544
55TAF15_26573619_Chip-Seq_HEK293_Human1.37783115
56* SOX2_20726797_ChIP-Seq_SW620_Human1.37698223
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35396302
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.35107931
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33298850
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33293347
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.30031482
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29690024
63GATA4_25053715_ChIP-Seq_YYC3_Human1.28019965
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27208224
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26336831
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26188773
67MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23051334
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.22803421
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21104706
70CBP_20019798_ChIP-Seq_JUKART_Human1.20367455
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20367455
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.19752209
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16448878
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16413652
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15871626
76CDX2_22108803_ChIP-Seq_LS180_Human1.15865666
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15759440
78PHF8_20622853_ChIP-Seq_HELA_Human1.13334967
79IRF1_19129219_ChIP-ChIP_H3396_Human1.12570554
80CDX2_20551321_ChIP-Seq_CACO-2_Human1.12358485
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12319872
82PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11748134
83TCF4_22108803_ChIP-Seq_LS180_Human1.11647710
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11639070
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11131148
86* AR_20517297_ChIP-Seq_VCAP_Human1.09569355
87ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09463637
88SMAD4_21799915_ChIP-Seq_A2780_Human1.08125996
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07662709
90STAT3_23295773_ChIP-Seq_U87_Human1.07401169
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.06284865
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.06178675
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05017617
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04987037
95HNFA_21074721_ChIP-Seq_CACO-2_Human1.04951132
96P300_19829295_ChIP-Seq_ESCs_Human1.04661730
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04527971
98SOX2_19829295_ChIP-Seq_ESCs_Human1.04412333
99NANOG_19829295_ChIP-Seq_ESCs_Human1.04412333
100* AR_25329375_ChIP-Seq_VCAP_Human1.03407293
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03212720
102PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01619277
103RUNX_20019798_ChIP-Seq_JUKART_Human1.01292908
104ESR2_21235772_ChIP-Seq_MCF-7_Human1.01063108
105FOXA2_19822575_ChIP-Seq_HepG2_Human1.00163618
106SCL_19346495_ChIP-Seq_HPC-7_Human0.99933780
107PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98822933
108NANOG_18555785_Chip-Seq_ESCs_Mouse0.98135581
109P53_22387025_ChIP-Seq_ESCs_Mouse0.98059266
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96394751
111VDR_24787735_ChIP-Seq_THP-1_Human0.95865703
112SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95682738
113CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95357009
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95164530
115TCF4_23295773_ChIP-Seq_U87_Human0.94576014
116CBP_21632823_ChIP-Seq_H3396_Human0.94287676
117STAT3_18555785_Chip-Seq_ESCs_Mouse0.94060191
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93812510
119NFYA_21822215_ChIP-Seq_K562_Human0.92814364
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92546008
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92453567
122GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92251307
123OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91167591
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91099427
125OCT4_18555785_Chip-Seq_ESCs_Mouse0.91062626
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90981257
127PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.90911554
128RUNX2_22187159_ChIP-Seq_PCA_Human0.90784709
129ETV1_20927104_ChIP-Seq_GIST48_Human0.90518061
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90268632
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90196336
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90194014
133FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90163517
134AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89745357
135SOX2_18555785_Chip-Seq_ESCs_Mouse0.89648478
136E2F1_18555785_Chip-Seq_ESCs_Mouse0.89585537
137PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.89202378
138GATA6_21074721_ChIP-Seq_CACO-2_Human0.89162162
139CJUN_26792858_Chip-Seq_BT549_Human0.89143808
140NCOR_22424771_ChIP-Seq_293T_Human0.88904450
141SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88882077
142P300_18555785_Chip-Seq_ESCs_Mouse0.88166590
143FLI1_27457419_Chip-Seq_LIVER_Mouse0.87564676
144* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87254337
145SMAD4_21741376_ChIP-Seq_EPCs_Human0.86970031
146SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86496174
147LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86152658
148STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86054545
149RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85644136
150CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85145881
151CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84852630
152PU_27001747_Chip-Seq_BMDM_Mouse0.84524614
153HNF4A_19822575_ChIP-Seq_HepG2_Human0.83622097
154EGR1_19374776_ChIP-ChIP_THP-1_Human0.80877359
155AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79202616
156ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78501574
157PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78297569
158CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77851190
159P63_26484246_Chip-Seq_KERATINOCYTES_Human0.77360554
160FOXA1_25552417_ChIP-Seq_VCAP_Human0.77340640
161SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.77271416
162SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.77271416
163GATA2_19941826_ChIP-Seq_K562_Human0.76440554
164ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.75615012
165GATA3_24758297_ChIP-Seq_MCF-7_Human0.75468632
166CDX2_19796622_ChIP-Seq_MESCs_Mouse0.75272006
167CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73345743
168GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.72546188
169PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72086145
170LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.71134403
171EGR1_19032775_ChIP-ChIP_M12_Human0.70841325
172FOXO3_23340844_ChIP-Seq_DLD1_Human0.70797653
173SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.70171345
174RXRA_24833708_ChIP-Seq_LIVER_Mouse0.67746963
175GATA3_26560356_Chip-Seq_TH2_Human0.66939411
176* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.65913845
177GATA2_22383799_ChIP-Seq_G1ME_Mouse0.65250462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.24150416
2MP0008875_abnormal_xenobiotic_pharmacok4.33586927
3MP0005365_abnormal_bile_salt4.32471235
4MP0005360_urolithiasis4.29440116
5MP0005085_abnormal_gallbladder_physiolo4.26778676
6MP0003191_abnormal_cellular_cholesterol2.93808455
7MP0010329_abnormal_lipoprotein_level2.80625848
8MP0003252_abnormal_bile_duct2.62183732
9MP0003806_abnormal_nucleotide_metabolis2.57809444
10MP0003186_abnormal_redox_activity2.48140385
11MP0009840_abnormal_foam_cell2.40225330
12MP0003195_calcinosis2.33181953
13MP0001835_abnormal_antigen_presentation2.14856322
14MP0003724_increased_susceptibility_to2.08879710
15MP0005083_abnormal_biliary_tract2.05133653
16MP0005058_abnormal_lysosome_morphology1.93701429
17MP0003436_decreased_susceptibility_to1.91824521
18MP0001666_abnormal_nutrient_absorption1.84917141
19MP0004782_abnormal_surfactant_physiolog1.83385031
20MP0000609_abnormal_liver_physiology1.75118723
21MP0005332_abnormal_amino_acid1.74632545
22MP0002118_abnormal_lipid_homeostasis1.66267306
23MP0005319_abnormal_enzyme/_coenzyme1.57556644
24MP0009785_altered_susceptibility_to1.56136821
25MP0005187_abnormal_penis_morphology1.53739501
26MP0001661_extended_life_span1.51947210
27MP0009697_abnormal_copulation1.51834253
28MP0002419_abnormal_innate_immunity1.51033801
29MP0004019_abnormal_vitamin_homeostasis1.51025954
30MP0009764_decreased_sensitivity_to1.50005320
31MP0008438_abnormal_cutaneous_collagen1.44334203
32MP0001764_abnormal_homeostasis1.41464642
33MP0005464_abnormal_platelet_physiology1.40583168
34MP0002138_abnormal_hepatobiliary_system1.38184867
35MP0002148_abnormal_hypersensitivity_rea1.35752881
36MP0006082_CNS_inflammation1.32492216
37MP0005408_hypopigmentation1.31286254
38MP0008469_abnormal_protein_level1.28146043
39MP0010368_abnormal_lymphatic_system1.27752573
40MP0005670_abnormal_white_adipose1.27252454
41MP0009643_abnormal_urine_homeostasis1.25472541
42MP0005584_abnormal_enzyme/coenzyme_acti1.23418431
43MP0008872_abnormal_physiological_respon1.19277761
44MP0002132_abnormal_respiratory_system1.18920937
45MP0005025_abnormal_response_to1.18590064
46MP0001533_abnormal_skeleton_physiology1.18168757
47MP0002877_abnormal_melanocyte_morpholog1.17518446
48MP0003656_abnormal_erythrocyte_physiolo1.11366182
49MP0005636_abnormal_mineral_homeostasis1.08954083
50MP0009763_increased_sensitivity_to1.06001102
51MP0001845_abnormal_inflammatory_respons1.02714493
52MP0005000_abnormal_immune_tolerance0.99922071
53MP0002254_reproductive_system_inflammat0.99482924
54MP0008004_abnormal_stomach_pH0.98710803
55MP0008789_abnormal_olfactory_epithelium0.98596675
56MP0005647_abnormal_sex_gland0.97881043
57MP0000598_abnormal_liver_morphology0.97203342
58MP0005164_abnormal_response_to0.96319537
59MP0003690_abnormal_glial_cell0.95935270
60MP0003075_altered_response_to0.95923478
61MP0001790_abnormal_immune_system0.95794683
62MP0005387_immune_system_phenotype0.95794683
63MP0002166_altered_tumor_susceptibility0.95499874
64MP0002909_abnormal_adrenal_gland0.94823597
65MP0009780_abnormal_chondrocyte_physiolo0.93808050
66MP0002006_tumorigenesis0.93563925
67MP0005499_abnormal_olfactory_system0.93452591
68MP0005394_taste/olfaction_phenotype0.93452591
69MP0000343_altered_response_to0.93340785
70MP0001853_heart_inflammation0.92226885
71MP0004130_abnormal_muscle_cell0.90653015
72MP0002295_abnormal_pulmonary_circulatio0.89562558
73MP0002452_abnormal_antigen_presenting0.89051171
74MP0002078_abnormal_glucose_homeostasis0.88694276
75MP0003705_abnormal_hypodermis_morpholog0.88125488
76MP0010155_abnormal_intestine_physiology0.87567727
77MP0005166_decreased_susceptibility_to0.87297249
78MP0005395_other_phenotype0.87191082
79MP0003279_aneurysm0.86513493
80MP0005646_abnormal_pituitary_gland0.85731888
81MP0005334_abnormal_fat_pad0.84626781
82MP0003879_abnormal_hair_cell0.83975240
83MP0001958_emphysema0.82869367
84MP0002168_other_aberrant_phenotype0.82205443
85MP0005551_abnormal_eye_electrophysiolog0.80363180
86MP0002405_respiratory_system_inflammati0.79954864
87MP0010386_abnormal_urinary_bladder0.79206781
88MP0002876_abnormal_thyroid_physiology0.79161787
89MP0002998_abnormal_bone_remodeling0.78705595
90MP0005376_homeostasis/metabolism_phenot0.78567210
91MP0001879_abnormal_lymphatic_vessel0.77816623
92MP0004947_skin_inflammation0.77723603
93MP0002723_abnormal_immune_serum0.76837095
94MP0000249_abnormal_blood_vessel0.76742078
95MP0004883_abnormal_blood_vessel0.76568486
96MP0005451_abnormal_body_composition0.76215535
97MP0001800_abnormal_humoral_immune0.75644667
98MP0009642_abnormal_blood_homeostasis0.75057089
99MP0002060_abnormal_skin_morphology0.75024260
100MP0002971_abnormal_brown_adipose0.73802596
101MP0000685_abnormal_immune_system0.73642468
102MP0001944_abnormal_pancreas_morphology0.73236346
103MP0003638_abnormal_response/metabolism_0.72330841
104MP0002282_abnormal_trachea_morphology0.72273176
105MP0003868_abnormal_feces_composition0.72017771
106MP0003011_delayed_dark_adaptation0.71881563
107MP0002933_joint_inflammation0.71616805
108MP0005671_abnormal_response_to0.71597216
109MP0003300_gastrointestinal_ulcer0.70324072
110MP0005535_abnormal_body_temperature0.69264760
111MP0001984_abnormal_olfaction0.68286106
112MP0002136_abnormal_kidney_physiology0.68192744
113MP0005666_abnormal_adipose_tissue0.68168867
114MP0005220_abnormal_exocrine_pancreas0.67355756
115MP0005084_abnormal_gallbladder_morpholo0.66941401
116MP0009384_cardiac_valve_regurgitation0.66903412
117MP0006036_abnormal_mitochondrial_physio0.64069342
118MP0005645_abnormal_hypothalamus_physiol0.63695050
119MP0002090_abnormal_vision0.60567860
120MP0005379_endocrine/exocrine_gland_phen0.59244487
121MP0005266_abnormal_metabolism0.57885085
122MP0002928_abnormal_bile_duct0.57049666
123MP0003122_maternal_imprinting0.56849332
124MP0001756_abnormal_urination0.55784218
125MP0003953_abnormal_hormone_level0.54801621
126MP0005448_abnormal_energy_balance0.53939920
127MP0002938_white_spotting0.52284341
128MP0004043_abnormal_pH_regulation0.51394637
129MP0009053_abnormal_anal_canal0.49304359
130MP0000639_abnormal_adrenal_gland0.47468775
131MP0000604_amyloidosis0.47258066
132MP0003718_maternal_effect0.44290989
133MP0008877_abnormal_DNA_methylation0.41890415
134MP0001501_abnormal_sleep_pattern0.38354526
135MP0005386_behavior/neurological_phenoty0.38176633
136MP0004924_abnormal_behavior0.38176633
137MP0001915_intracranial_hemorrhage0.37936497
138MP0002693_abnormal_pancreas_physiology0.37672827
139MP0006072_abnormal_retinal_apoptosis0.37109663
140MP0000566_synostosis0.35632946
141MP0003633_abnormal_nervous_system0.34738219
142MP0003878_abnormal_ear_physiology0.34623248
143MP0005377_hearing/vestibular/ear_phenot0.34623248
144MP0001986_abnormal_taste_sensitivity0.34493204
145MP0001485_abnormal_pinna_reflex0.34452985
146MP0004133_heterotaxia0.34360739
147MP0003283_abnormal_digestive_organ0.33355165
148MP0009745_abnormal_behavioral_response0.31921171
149MP0001324_abnormal_eye_pigmentation0.31429020
150MP0003787_abnormal_imprinting0.30862480

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)4.72133849
2Complement deficiency (HP:0004431)4.70026018
3Intrahepatic cholestasis (HP:0001406)4.69753556
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.66091995
5Deep venous thrombosis (HP:0002625)4.46409893
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.36281897
7Xanthomatosis (HP:0000991)4.29521983
8Systemic lupus erythematosus (HP:0002725)4.21604382
9Abnormality of complement system (HP:0005339)3.95796935
10Joint hemorrhage (HP:0005261)3.94097220
11Recurrent gram-negative bacterial infections (HP:0005420)3.89845411
12Hyperlipoproteinemia (HP:0010980)3.56702582
13Abnormality of the intrinsic pathway (HP:0010989)3.56583718
14Hypobetalipoproteinemia (HP:0003563)3.54854840
15Abnormality of the common coagulation pathway (HP:0010990)3.51761950
16Hypoglycemic coma (HP:0001325)3.47634788
17Fat malabsorption (HP:0002630)3.32180366
18Myocardial infarction (HP:0001658)3.30480454
19Hypoalphalipoproteinemia (HP:0003233)3.28333338
20Vacuolated lymphocytes (HP:0001922)3.24760843
21Abnormality of fatty-acid metabolism (HP:0004359)3.24103434
22Epidermoid cyst (HP:0200040)3.22597581
23Hypolipoproteinemia (HP:0010981)3.21109761
24Glomerulonephritis (HP:0000099)3.15150882
25Hyperammonemia (HP:0001987)3.11222888
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.07278892
27Hypercholesterolemia (HP:0003124)3.05206972
28Eczematoid dermatitis (HP:0000976)3.01403151
29Conjugated hyperbilirubinemia (HP:0002908)2.94783510
30Abnormality of glutamine family amino acid metabolism (HP:0010902)2.90093490
31Steatorrhea (HP:0002570)2.89171428
32Hyperglycinuria (HP:0003108)2.87263030
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.84724966
34Generalized aminoaciduria (HP:0002909)2.79788825
35Fair hair (HP:0002286)2.77161454
36Recurrent bacterial skin infections (HP:0005406)2.76717582
37Recurrent abscess formation (HP:0002722)2.66388897
38Ketosis (HP:0001946)2.65071002
39Axonal loss (HP:0003447)2.60336119
40Abnormality of methionine metabolism (HP:0010901)2.59542583
41Hypothermia (HP:0002045)2.56460030
42Hyperbilirubinemia (HP:0002904)2.54242790
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.54236958
44Hyperglycinemia (HP:0002154)2.51288117
45Hepatocellular carcinoma (HP:0001402)2.50575550
46Renal cortical cysts (HP:0000803)2.49525467
47Hypoglycemic seizures (HP:0002173)2.44717267
48Hyperglycemia (HP:0003074)2.43978504
49Abnormality of sulfur amino acid metabolism (HP:0004339)2.43630851
50Abnormality of serine family amino acid metabolism (HP:0010894)2.43178432
51Abnormality of glycine metabolism (HP:0010895)2.43178432
52Urinary glycosaminoglycan excretion (HP:0003541)2.42585299
53Mucopolysacchariduria (HP:0008155)2.42585299
54Glycosuria (HP:0003076)2.40890823
55Abnormality of urine glucose concentration (HP:0011016)2.40890823
56Gingival bleeding (HP:0000225)2.39026601
57Osteomalacia (HP:0002749)2.34836596
58Vascular calcification (HP:0004934)2.34267604
59Nephritis (HP:0000123)2.34084774
60Hyperphosphaturia (HP:0003109)2.30647132
61Proximal tubulopathy (HP:0000114)2.29880374
62Nausea (HP:0002018)2.29447856
63Rickets (HP:0002748)2.27030935
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.26631115
65Abnormality of polysaccharide metabolism (HP:0011012)2.26631115
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.26631115
67Arthropathy (HP:0003040)2.24408055
68Interstitial pulmonary disease (HP:0006530)2.23667772
69Dysostosis multiplex (HP:0000943)2.23535291
70Amyloidosis (HP:0011034)2.20797726
71Esophageal varix (HP:0002040)2.20605529
72Dicarboxylic aciduria (HP:0003215)2.20419024
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20419024
74Cardiovascular calcification (HP:0011915)2.19863945
75Ketoacidosis (HP:0001993)2.18553715
76Abnormal cartilage morphology (HP:0002763)2.18236276
77Menorrhagia (HP:0000132)2.16862798
78Hyperinsulinemic hypoglycemia (HP:0000825)2.16540725
79Abnormality of vitamin metabolism (HP:0100508)2.15581403
80Abnormality of pyrimidine metabolism (HP:0004353)2.14387502
81Pancreatitis (HP:0001733)2.12651154
82Mitral stenosis (HP:0001718)2.12475355
83Cerebral palsy (HP:0100021)2.09804532
84Abnormality of nucleobase metabolism (HP:0010932)2.08388940
85Hypertriglyceridemia (HP:0002155)2.07919157
86Abnormality of purine metabolism (HP:0004352)2.05389659
87Periodontitis (HP:0000704)2.03326535
88Abnormality of macrophages (HP:0004311)2.03080203
89Metabolic acidosis (HP:0001942)2.02889860
90Beaking of vertebral bodies (HP:0004568)2.00319343
91Abnormal biliary tract physiology (HP:0012439)1.99580910
92Bile duct proliferation (HP:0001408)1.99580910
93Skin nodule (HP:0200036)1.99558654
94Generalized hypopigmentation of hair (HP:0011358)1.99450209
95Abnormality of proline metabolism (HP:0010907)1.97626452
96Hydroxyprolinuria (HP:0003080)1.97626452
97Osteolytic defects of the phalanges of the hand (HP:0009771)1.97402573
98Osteolytic defects of the hand bones (HP:0009699)1.97402573
99Irritability (HP:0000737)1.93933154
100Reduced antithrombin III activity (HP:0001976)1.92307585
101Abnormal tarsal ossification (HP:0008369)1.90595740
102Blue irides (HP:0000635)1.87211656
103Epistaxis (HP:0000421)1.85686612
104Opisthotonus (HP:0002179)1.85428706
105Autoimmune thrombocytopenia (HP:0001973)1.82869715
106Nonimmune hydrops fetalis (HP:0001790)1.82621854
107Purpura (HP:0000979)1.82541586
108Pulmonary embolism (HP:0002204)1.82075746
109Neonatal hypoglycemia (HP:0001998)1.78973180
110Spontaneous abortion (HP:0005268)1.78396860
111Thrombophlebitis (HP:0004418)1.78177446
112Cerebral edema (HP:0002181)1.77902101
113Abnormality of serum amino acid levels (HP:0003112)1.77333216
114Renal tubular acidosis (HP:0001947)1.76547309
115Hemorrhage of the eye (HP:0011885)1.75396154
116Delayed CNS myelination (HP:0002188)1.74705756
117Respiratory distress (HP:0002098)1.74432096
118Abnormal urine phosphate concentration (HP:0012599)1.73785036
119Lethargy (HP:0001254)1.73039711
120Increased serum pyruvate (HP:0003542)1.71285550
121Pancreatic islet-cell hyperplasia (HP:0004510)1.71194683
122Hepatosplenomegaly (HP:0001433)1.70798126
123Increased mean platelet volume (HP:0011877)1.70333939
124Enlarged kidneys (HP:0000105)1.68953553
125Bifid scrotum (HP:0000048)1.66059391
126Abnormality of transition element cation homeostasis (HP:0011030)1.64701947
127Abnormal gallbladder morphology (HP:0012437)1.64391880
128Abnormality of endocrine pancreas physiology (HP:0012093)1.62557934
129Abnormality of the pancreatic islet cells (HP:0006476)1.62557934
130Hypophosphatemic rickets (HP:0004912)1.62554900
131Retinal atrophy (HP:0001105)1.60045241
132Alkalosis (HP:0001948)1.58708835
133Late onset (HP:0003584)1.55142878
134Abnormality of iron homeostasis (HP:0011031)1.54289995
135Joint swelling (HP:0001386)1.53320150
136Cholelithiasis (HP:0001081)1.46906102
137Abnormality of glycolysis (HP:0004366)1.46884624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.24128032
2BCKDK3.14896046
3PINK13.08478717
4MAP3K142.96267500
5TGFBR22.80153157
6NTRK32.64279364
7FRK2.61498882
8MAP4K22.35458235
9ZAK2.30284462
10WNK32.22694650
11MAP3K32.22449303
12MST1R2.15858415
13NEK92.14545632
14TBK12.12760993
15FER2.08276418
16TYK22.06772324
17IRAK32.00679031
18INSRR1.86041757
19TAOK31.82289781
20BLK1.75787579
21FGFR41.75599686
22IKBKE1.74805799
23MAP2K31.73215811
24PBK1.72002316
25ERBB31.70604126
26PIK3CG1.68391921
27TEC1.66590434
28FGFR21.64910450
29PAK31.64269977
30CASK1.63656310
31BMPR21.62657590
32IRAK41.58470470
33SIK11.56221498
34JAK11.50133933
35PRKCG1.46146512
36KIT1.42590742
37MAP3K41.41323285
38STK38L1.37724704
39TNK21.34282069
40TRPM71.30479643
41MAPK151.27090942
42DAPK21.26581947
43IKBKB1.25679524
44MAP4K11.25347720
45PRKCE1.24139748
46TXK1.19302834
47PDK21.18784466
48RIPK11.18034699
49STK391.13311734
50AKT31.13229645
51TIE11.11909051
52PRKACG1.09207171
53FLT31.08245428
54PIK3CA1.08085204
55FGFR31.06611359
56JAK21.06271050
57TRIB31.05837417
58PIM21.04184615
59GRK71.03719607
60MST41.03005935
61RIPK41.01974294
62ZAP700.99835632
63JAK30.99212970
64EPHA30.98925251
65CSF1R0.98551644
66BTK0.98542297
67CAMK1D0.98213394
68MAP3K120.96782799
69CHUK0.96424337
70OXSR10.93917285
71ACVR1B0.92118376
72PHKG20.91241733
73PHKG10.91241733
74EPHA20.90233266
75NME20.90233155
76WNK40.87511676
77ABL20.85000480
78STK100.84948873
79PRKG10.82496766
80PRKACA0.80305126
81CSK0.79685482
82MAPK110.79574785
83BRSK20.79357059
84TRIM280.79113680
85MAPKAPK30.78230556
86PKN20.78038055
87MAP2K60.77607882
88ERBB40.77017531
89PRKG20.76652257
90TNIK0.75357182
91LYN0.74645648
92EPHA40.74446228
93CDK60.73703006
94CSNK1G10.73410607
95KDR0.73359326
96PRKAA10.72645517
97MYLK0.72458960
98STK40.72028621
99NLK0.71713023
100ADRBK20.70056160
101PRKCI0.69925526
102LATS10.69657994
103MAP2K40.69497238
104EIF2AK20.69027345
105MAP3K20.68046306
106PRKACB0.65211487
107NUAK10.64639080
108ITK0.64182482
109RPS6KA40.64038862
110CAMK2D0.63761020
111PTK60.62886709
112MKNK20.61500728
113SGK30.61105808
114MAP3K100.60150650
115PNCK0.60059487
116PIM10.59343650
117CSNK1D0.59139307
118MAP3K110.58732698
119SGK20.57879373
120MATK0.57670435
121MAPK130.57428896
122PRKAA20.55259620
123BCR0.54865088
124STK30.54790049
125ADRBK10.54306270
126SYK0.53750293
127GRK10.53607410
128CSNK1A10.52445394
129EIF2AK10.51838318
130PRKCZ0.51652453
131PRKCA0.51368955
132IGF1R0.51152383
133PRKCD0.51080276
134MAP2K70.49038278
135IRAK10.47970801
136EPHB10.47968105
137DYRK20.47657721
138BMPR1B0.47593003
139EPHB20.47405687
140MAP2K10.44852903
141CSNK1G20.44844873
142RPS6KB20.43718952
143MAPK70.43691834
144RPS6KA60.43198474
145CSNK1G30.42620068
146PTK2B0.42319003
147PDPK10.41852020
148PLK20.40304791
149ERBB20.40285005
150MET0.40237160
151ABL10.40068298
152EIF2AK30.39262285
153GSK3A0.39196732
154CSNK1E0.38833197
155LRRK20.38535654
156CSNK1A1L0.37297305
157PRKCB0.37052983
158STK380.36623612
159PTK20.34508859
160MUSK0.33161602
161FGFR10.31819414
162LIMK10.31596483

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose and glucuronate interconversions_Homo sapiens_hsa000403.73335553
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.69160088
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.51959369
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.89378291
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.71679161
6Chemical carcinogenesis_Homo sapiens_hsa052042.56546726
7Staphylococcus aureus infection_Homo sapiens_hsa051502.54636110
8Sulfur metabolism_Homo sapiens_hsa009202.52344868
9Complement and coagulation cascades_Homo sapiens_hsa046102.48372092
10Fatty acid degradation_Homo sapiens_hsa000712.35316522
11Caffeine metabolism_Homo sapiens_hsa002322.24862526
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.07532080
13Tryptophan metabolism_Homo sapiens_hsa003802.04742506
14Steroid hormone biosynthesis_Homo sapiens_hsa001402.00925141
15Peroxisome_Homo sapiens_hsa041461.95578388
16Linoleic acid metabolism_Homo sapiens_hsa005911.92763996
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.91131840
18Nitrogen metabolism_Homo sapiens_hsa009101.89724826
19Starch and sucrose metabolism_Homo sapiens_hsa005001.84633384
20PPAR signaling pathway_Homo sapiens_hsa033201.81000099
21Retinol metabolism_Homo sapiens_hsa008301.78708007
22Propanoate metabolism_Homo sapiens_hsa006401.72070228
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.71552971
24Histidine metabolism_Homo sapiens_hsa003401.68391872
25Arginine biosynthesis_Homo sapiens_hsa002201.67004840
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.61819481
27beta-Alanine metabolism_Homo sapiens_hsa004101.60740202
28Fatty acid metabolism_Homo sapiens_hsa012121.56137329
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56051506
30Butanoate metabolism_Homo sapiens_hsa006501.52065376
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45676099
32Selenocompound metabolism_Homo sapiens_hsa004501.44015188
33Sulfur relay system_Homo sapiens_hsa041221.41832947
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40015088
35Phenylalanine metabolism_Homo sapiens_hsa003601.28910948
36Glutathione metabolism_Homo sapiens_hsa004801.27603511
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.27145093
38Folate biosynthesis_Homo sapiens_hsa007901.26891196
39ABC transporters_Homo sapiens_hsa020101.25976323
40Vitamin B6 metabolism_Homo sapiens_hsa007501.20684653
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18972363
42Tyrosine metabolism_Homo sapiens_hsa003501.10040221
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09486626
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05323245
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.00437444
46Other glycan degradation_Homo sapiens_hsa005111.00178301
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97202664
48Legionellosis_Homo sapiens_hsa051340.93218320
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89566643
50Fat digestion and absorption_Homo sapiens_hsa049750.85478736
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.83577316
52Galactose metabolism_Homo sapiens_hsa000520.83162223
53Steroid biosynthesis_Homo sapiens_hsa001000.83102821
54Lysosome_Homo sapiens_hsa041420.82526883
55Leishmaniasis_Homo sapiens_hsa051400.79987818
56Fatty acid elongation_Homo sapiens_hsa000620.79907842
57Pertussis_Homo sapiens_hsa051330.76445107
58Pyruvate metabolism_Homo sapiens_hsa006200.74896811
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73492957
60Protein export_Homo sapiens_hsa030600.73351983
61Vitamin digestion and absorption_Homo sapiens_hsa049770.72425452
62Carbon metabolism_Homo sapiens_hsa012000.71980937
63Bile secretion_Homo sapiens_hsa049760.70438283
64Malaria_Homo sapiens_hsa051440.68959974
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.62283798
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62034711
67Glycerolipid metabolism_Homo sapiens_hsa005610.61556614
68Fatty acid biosynthesis_Homo sapiens_hsa000610.60222449
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59200614
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58535707
71Rheumatoid arthritis_Homo sapiens_hsa053230.55226312
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53712381
73Pentose phosphate pathway_Homo sapiens_hsa000300.52368844
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52006726
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.50486163
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49160288
77Prion diseases_Homo sapiens_hsa050200.47597145
78Phagosome_Homo sapiens_hsa041450.47448640
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.46055784
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44960535
81Arginine and proline metabolism_Homo sapiens_hsa003300.44878189
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.43070049
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.42435594
84Graft-versus-host disease_Homo sapiens_hsa053320.42244416
85Tuberculosis_Homo sapiens_hsa051520.41022497
86Insulin resistance_Homo sapiens_hsa049310.40402523
87Arachidonic acid metabolism_Homo sapiens_hsa005900.39387373
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38404146
89* Metabolic pathways_Homo sapiens_hsa011000.38023244
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38018447
91Biosynthesis of amino acids_Homo sapiens_hsa012300.35646513
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34955372
93TNF signaling pathway_Homo sapiens_hsa046680.34824043
94Osteoclast differentiation_Homo sapiens_hsa043800.34184879
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34116143
96One carbon pool by folate_Homo sapiens_hsa006700.33026982
97African trypanosomiasis_Homo sapiens_hsa051430.32209670
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32079009
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31009138
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26584922
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26458458
102Lysine degradation_Homo sapiens_hsa003100.21111052
103Mineral absorption_Homo sapiens_hsa049780.20876661
104Glucagon signaling pathway_Homo sapiens_hsa049220.20576744
105Hepatitis C_Homo sapiens_hsa051600.20553013
106Influenza A_Homo sapiens_hsa051640.20513558
107Fructose and mannose metabolism_Homo sapiens_hsa000510.19050289
108Measles_Homo sapiens_hsa051620.18914239
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18631616
110Serotonergic synapse_Homo sapiens_hsa047260.14282414
111Sphingolipid metabolism_Homo sapiens_hsa006000.10977249
112Circadian rhythm_Homo sapiens_hsa047100.06795365
113Insulin secretion_Homo sapiens_hsa049110.04392081
114Ether lipid metabolism_Homo sapiens_hsa005650.02880532
115Type II diabetes mellitus_Homo sapiens_hsa049300.02876986
116Ovarian steroidogenesis_Homo sapiens_hsa049130.02447146
117Renin-angiotensin system_Homo sapiens_hsa046140.02380301
118Regulation of autophagy_Homo sapiens_hsa04140-0.1043207
119Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1018877
120Phototransduction_Homo sapiens_hsa04744-0.0966296
121Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0950648
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0925585
123N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0869748
124Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0471161
125Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0425238
126AMPK signaling pathway_Homo sapiens_hsa04152-0.0330947
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0169783

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