POP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.79201685
2central nervous system myelination (GO:0022010)5.79201685
3negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.47650174
4protein complex biogenesis (GO:0070271)4.32686880
5regulation of mitochondrial translation (GO:0070129)4.22199892
6negative regulation of ligase activity (GO:0051352)4.16166838
7negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.16166838
8respiratory electron transport chain (GO:0022904)4.15892064
9proteasome assembly (GO:0043248)4.15826923
10regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.12101376
11transcription elongation from RNA polymerase III promoter (GO:0006385)4.11943575
12termination of RNA polymerase III transcription (GO:0006386)4.11943575
13DNA deamination (GO:0045006)4.11300014
14positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.10177142
15protein neddylation (GO:0045116)4.09762123
16electron transport chain (GO:0022900)4.09753204
17mitochondrial respiratory chain complex assembly (GO:0033108)4.09438690
18anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.08702365
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.02716500
20cullin deneddylation (GO:0010388)3.99394295
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.98163607
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.98163607
23NADH dehydrogenase complex assembly (GO:0010257)3.98163607
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.90085736
25respiratory chain complex IV assembly (GO:0008535)3.88366741
26energy coupled proton transport, down electrochemical gradient (GO:0015985)3.84210974
27ATP synthesis coupled proton transport (GO:0015986)3.84210974
28establishment of integrated proviral latency (GO:0075713)3.84101648
297-methylguanosine mRNA capping (GO:0006370)3.81069741
30RNA capping (GO:0036260)3.74589262
317-methylguanosine RNA capping (GO:0009452)3.74589262
32regulation of cellular amino acid metabolic process (GO:0006521)3.73369753
33DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.71473807
34ribosomal small subunit biogenesis (GO:0042274)3.69729431
35transcription elongation from RNA polymerase I promoter (GO:0006362)3.66384295
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.64077435
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.64077435
38protein deneddylation (GO:0000338)3.62175441
39chaperone-mediated protein transport (GO:0072321)3.61083142
40signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.59993468
41signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.59993468
42signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.59993468
43viral transcription (GO:0019083)3.59871086
44cytochrome complex assembly (GO:0017004)3.58090110
45translational termination (GO:0006415)3.57491420
46positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.55189876
47pseudouridine synthesis (GO:0001522)3.54933498
48positive regulation of prostaglandin secretion (GO:0032308)3.54821995
49signal transduction involved in DNA integrity checkpoint (GO:0072401)3.53668781
50signal transduction involved in DNA damage checkpoint (GO:0072422)3.53668781
51rRNA modification (GO:0000154)3.52934491
52signal transduction involved in cell cycle checkpoint (GO:0072395)3.52912708
53DNA strand elongation involved in DNA replication (GO:0006271)3.42925287
54protein localization to mitochondrion (GO:0070585)3.42287670
55L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.41105031
56positive regulation of ligase activity (GO:0051351)3.40689115
57termination of RNA polymerase I transcription (GO:0006363)3.39993084
58fatty acid elongation (GO:0030497)3.39602499
59maturation of SSU-rRNA (GO:0030490)3.38225287
60ribosomal large subunit biogenesis (GO:0042273)3.37635579
61establishment of protein localization to mitochondrial membrane (GO:0090151)3.35511846
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35120273
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35120273
64spliceosomal snRNP assembly (GO:0000387)3.34153902
65formation of translation preinitiation complex (GO:0001731)3.30775768
66regulation of ubiquitin-protein transferase activity (GO:0051438)3.27493976
67DNA strand elongation (GO:0022616)3.24322916
68regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22723656
69regulation of collateral sprouting (GO:0048670)3.22141739
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.20532946
71transcription from RNA polymerase I promoter (GO:0006360)3.20471613
72translational initiation (GO:0006413)3.19930419
73establishment of viral latency (GO:0019043)3.19020574
74protein-cofactor linkage (GO:0018065)3.17670379
75regulation of ligase activity (GO:0051340)3.16488419
76positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.15718669
77inner mitochondrial membrane organization (GO:0007007)3.14234656
78* rRNA processing (GO:0006364)3.11900296
79DNA damage response, detection of DNA damage (GO:0042769)3.11807453
80transcription-coupled nucleotide-excision repair (GO:0006283)3.11553131
81CENP-A containing nucleosome assembly (GO:0034080)3.11180451
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11148022
83mannosylation (GO:0097502)3.10696740
84mitotic metaphase plate congression (GO:0007080)3.10336487
85ribosome assembly (GO:0042255)3.10117560
86mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.10020288
87iron-sulfur cluster assembly (GO:0016226)3.09727673
88metallo-sulfur cluster assembly (GO:0031163)3.09727673
89negative regulation of protein ubiquitination (GO:0031397)3.07553987
90transcription elongation from RNA polymerase II promoter (GO:0006368)3.07055628
91cotranslational protein targeting to membrane (GO:0006613)3.05883204
92translation (GO:0006412)3.05245840
93translational elongation (GO:0006414)3.04614587
94cellular protein complex disassembly (GO:0043624)3.03913514
95long-chain fatty acid biosynthetic process (GO:0042759)3.03267323
96ribonucleoprotein complex biogenesis (GO:0022613)3.02463540
97nucleobase biosynthetic process (GO:0046112)3.01386130
98microtubule polymerization or depolymerization (GO:0031109)3.00869686
99DNA replication checkpoint (GO:0000076)3.00523478
100telomere maintenance via semi-conservative replication (GO:0032201)2.99842249
101protein targeting to mitochondrion (GO:0006626)2.99531424
102DNA-templated transcription, elongation (GO:0006354)2.99179394
103transcription initiation from RNA polymerase I promoter (GO:0006361)2.98951574
104DNA replication initiation (GO:0006270)2.98449449
105establishment of protein localization to mitochondrion (GO:0072655)2.98227387
106SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97844254
107protein targeting to ER (GO:0045047)2.97699656
108signal transduction in response to DNA damage (GO:0042770)2.97560097
109exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97239045
110* rRNA metabolic process (GO:0016072)2.97233699
111positive regulation of cell cycle arrest (GO:0071158)2.96996060
112regulation of cellular amine metabolic process (GO:0033238)2.96664103
113viral mRNA export from host cell nucleus (GO:0046784)2.96653699
114deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.96081151
115myelination (GO:0042552)2.96045679
116DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.95794638
117cholesterol biosynthetic process (GO:0006695)2.95726011
118pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.94759552
119antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.94437679
120* tRNA processing (GO:0008033)2.93787462
121ensheathment of neurons (GO:0007272)2.93077070
122axon ensheathment (GO:0008366)2.93077070
123purine nucleobase biosynthetic process (GO:0009113)2.92058286
124spliceosomal complex assembly (GO:0000245)2.90197126
125G1/S transition of mitotic cell cycle (GO:0000082)2.90134591
126cell cycle G1/S phase transition (GO:0044843)2.90134591
127chromatin remodeling at centromere (GO:0031055)2.88718702
128viral life cycle (GO:0019058)2.88618386
129cellular component biogenesis (GO:0044085)2.88494911
130negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.87424808
131maturation of 5.8S rRNA (GO:0000460)2.85488969
132antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.84451624
133ubiquinone biosynthetic process (GO:0006744)2.83684400
134regulation of cell cycle arrest (GO:0071156)2.81374012
135regulation of mitotic spindle checkpoint (GO:1903504)2.80876050
136regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.80876050
137regulation of prostaglandin secretion (GO:0032306)2.80049414
138pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.79504965
139base-excision repair, AP site formation (GO:0006285)2.78121482
140negative regulation of cell cycle G1/S phase transition (GO:1902807)2.77617816
141negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.77617816
142* tRNA metabolic process (GO:0006399)2.76376269
143GTP biosynthetic process (GO:0006183)2.76322667
144water-soluble vitamin biosynthetic process (GO:0042364)2.76312729
145oxidative phosphorylation (GO:0006119)2.76217283
146mitochondrial transport (GO:0006839)2.75728625

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.48202038
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.65894291
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.59867003
4E2F7_22180533_ChIP-Seq_HELA_Human4.52704974
5GABP_17652178_ChIP-ChIP_JURKAT_Human4.14963333
6MYC_18555785_ChIP-Seq_MESCs_Mouse4.07688840
7EST1_17652178_ChIP-ChIP_JURKAT_Human4.05731634
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.81068466
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.78505534
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.66374629
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.61391931
12* CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.31217768
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.25868029
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89823701
15* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.89118383
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88811375
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86444254
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84532948
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78308833
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.75163247
21* VDR_23849224_ChIP-Seq_CD4+_Human2.55442264
22XRN2_22483619_ChIP-Seq_HELA_Human2.38956876
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33525174
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29039172
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23495089
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23137625
27DCP1A_22483619_ChIP-Seq_HELA_Human2.22166665
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16224133
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10481214
30FOXM1_23109430_ChIP-Seq_U2OS_Human2.07745673
31TTF2_22483619_ChIP-Seq_HELA_Human2.04026012
32FOXP3_21729870_ChIP-Seq_TREG_Human2.02370948
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.99525877
34ELK1_19687146_ChIP-ChIP_HELA_Human1.96744630
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94169532
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.94161242
37* GABP_19822575_ChIP-Seq_HepG2_Human1.88095793
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.87714912
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87430672
40* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87069806
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81616650
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79014636
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.72268812
44AR_21909140_ChIP-Seq_LNCAP_Human1.70805336
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.68138399
46* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64180937
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58573826
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54387809
49KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.46875699
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44034225
51* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37290550
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37045405
53* MYC_18940864_ChIP-ChIP_HL60_Human1.34767600
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34292283
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.32973773
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.31409042
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29818647
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28701988
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.28149748
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22801981
61HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21032047
62TFEB_21752829_ChIP-Seq_HELA_Human1.17125506
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13789679
64SOX17_20123909_ChIP-Seq_XEN_Mouse1.13576532
65ZNF274_21170338_ChIP-Seq_K562_Hela1.13130893
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12913256
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11980812
68* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11294183
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09986107
70KDM5A_27292631_Chip-Seq_BREAST_Human1.08907770
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06708616
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05810715
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02974015
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02681984
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02552996
76IRF1_19129219_ChIP-ChIP_H3396_Human1.02147898
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02002878
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00862685
79SOX2_16153702_ChIP-ChIP_HESCs_Human0.99889693
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98210487
81EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93612097
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91797686
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91208392
84E2F1_21310950_ChIP-Seq_MCF-7_Human0.90048905
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89397164
86IRF8_21731497_ChIP-ChIP_J774_Mouse0.88385026
87FUS_26573619_Chip-Seq_HEK293_Human0.86700076
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86592353
89IRF8_22096565_ChIP-ChIP_GC-B_Human0.86020119
90SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85304780
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83657624
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83333621
93CIITA_25753668_ChIP-Seq_RAJI_Human0.82511344
94EWS_26573619_Chip-Seq_HEK293_Human0.82159043
95VDR_22108803_ChIP-Seq_LS180_Human0.81986947
96* SPI1_23547873_ChIP-Seq_NB4_Human0.81857420
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80873273
98TP53_22573176_ChIP-Seq_HFKS_Human0.80863000
99NANOG_16153702_ChIP-ChIP_HESCs_Human0.79928243
100BP1_19119308_ChIP-ChIP_Hs578T_Human0.79841116
101NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78765719
102GATA1_26923725_Chip-Seq_HPCs_Mouse0.78010892
103* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77611745
104RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77114321
105FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76597078
106NANOG_18692474_ChIP-Seq_MEFs_Mouse0.76453214
107* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.75980758
108ELF5_23300383_ChIP-Seq_T47D_Human0.75872781
109* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.74124968
110FOXP1_21924763_ChIP-Seq_HESCs_Human0.72345399
111CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.71878581
112KLF4_18555785_ChIP-Seq_MESCs_Mouse0.71538005
113* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.70465078
114SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.70343821
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.69828091
116* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69720243
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.69218569
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68110931
119TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.67419881
120TCF3_18692474_ChIP-Seq_MEFs_Mouse0.66880108
121CTCF_18555785_ChIP-Seq_MESCs_Mouse0.66537922
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.65989289
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.65937955
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.63101595
125NANOG_21062744_ChIP-ChIP_HESCs_Human0.62655500
126SALL1_21062744_ChIP-ChIP_HESCs_Human0.62406779

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.22841304
2MP0008932_abnormal_embryonic_tissue3.02932477
3MP0001529_abnormal_vocalization3.02397093
4MP0004957_abnormal_blastocyst_morpholog2.97941437
5MP0008057_abnormal_DNA_replication2.89050799
6MP0010094_abnormal_chromosome_stability2.85502170
7MP0008877_abnormal_DNA_methylation2.70518295
8MP0003077_abnormal_cell_cycle2.67247936
9MP0008058_abnormal_DNA_repair2.63872370
10MP0003111_abnormal_nucleus_morphology2.63862999
11MP0000920_abnormal_myelination2.49939009
12MP0001905_abnormal_dopamine_level2.49287682
13MP0003718_maternal_effect2.45363105
14MP0003136_yellow_coat_color2.24947198
15MP0008875_abnormal_xenobiotic_pharmacok2.22757774
16MP0008260_abnormal_autophagy2.19562888
17MP0005671_abnormal_response_to2.15354776
18MP0003950_abnormal_plasma_membrane2.14767793
19MP0002148_abnormal_hypersensitivity_rea2.08441067
20MP0005451_abnormal_body_composition2.02237779
21MP0005075_abnormal_melanosome_morpholog2.00559972
22MP0005171_absent_coat_pigmentation1.99750898
23MP0001764_abnormal_homeostasis1.92766089
24MP0002102_abnormal_ear_morphology1.80069582
25MP0003806_abnormal_nucleotide_metabolis1.79459983
26MP0002938_white_spotting1.79313893
27MP0001730_embryonic_growth_arrest1.75665423
28MP0000566_synostosis1.75058376
29MP0002095_abnormal_skin_pigmentation1.72458235
30MP0009785_altered_susceptibility_to1.70841253
31MP0005410_abnormal_fertilization1.70699705
32MP0000015_abnormal_ear_pigmentation1.69530566
33MP0004147_increased_porphyrin_level1.68401178
34MP0000778_abnormal_nervous_system1.67238329
35MP0001485_abnormal_pinna_reflex1.56743687
36MP0006292_abnormal_olfactory_placode1.56260539
37MP0000685_abnormal_immune_system1.55788469
38MP0008872_abnormal_physiological_respon1.55217167
39MP0005084_abnormal_gallbladder_morpholo1.50755214
40MP0003880_abnormal_central_pattern1.50298450
41MP0000358_abnormal_cell_content/1.49113880
42MP0008007_abnormal_cellular_replicative1.47717104
43MP0001727_abnormal_embryo_implantation1.46318932
44MP0003195_calcinosis1.44016063
45MP0003938_abnormal_ear_development1.42576458
46MP0003937_abnormal_limbs/digits/tail_de1.41662877
47MP0002210_abnormal_sex_determination1.40882866
48MP0008789_abnormal_olfactory_epithelium1.40827356
49MP0004742_abnormal_vestibular_system1.36335825
50MP0004133_heterotaxia1.36210533
51MP0004381_abnormal_hair_follicle1.35549385
52MP0001188_hyperpigmentation1.33385422
53MP0002876_abnormal_thyroid_physiology1.30915430
54MP0000350_abnormal_cell_proliferation1.30203836
55MP0005379_endocrine/exocrine_gland_phen1.28647944
56MP0003786_premature_aging1.27224954
57MP0000516_abnormal_urinary_system1.27043438
58MP0005367_renal/urinary_system_phenotyp1.27043438
59MP0005389_reproductive_system_phenotype1.26336601
60MP0009697_abnormal_copulation1.24451813
61MP0001929_abnormal_gametogenesis1.23706049
62MP0002138_abnormal_hepatobiliary_system1.23388831
63MP0001835_abnormal_antigen_presentation1.23179056
64MP0002132_abnormal_respiratory_system1.23047531
65MP0010030_abnormal_orbit_morphology1.22606079
66MP0005408_hypopigmentation1.22498477
67MP0005083_abnormal_biliary_tract1.19575658
68MP0002653_abnormal_ependyma_morphology1.19158730
69MP0009250_abnormal_appendicular_skeleto1.18791043
70MP0001293_anophthalmia1.17910177
71MP0001145_abnormal_male_reproductive1.17708823
72MP0001919_abnormal_reproductive_system1.17621697
73MP0006082_CNS_inflammation1.17195623
74MP0005174_abnormal_tail_pigmentation1.16789581
75MP0002751_abnormal_autonomic_nervous1.15622146
76MP0003011_delayed_dark_adaptation1.14782906
77MP0009379_abnormal_foot_pigmentation1.14696370
78MP0003315_abnormal_perineum_morphology1.14608662
79MP0004142_abnormal_muscle_tone1.14197646
80MP0003698_abnormal_male_reproductive1.13507702
81MP0002277_abnormal_respiratory_mucosa1.10876473
82MP0005409_darkened_coat_color1.09950575
83MP0003634_abnormal_glial_cell1.09948763
84MP0002837_dystrophic_cardiac_calcinosis1.09745407
85MP0009764_decreased_sensitivity_to1.09300683
86MP0001873_stomach_inflammation1.08567423
87MP0002723_abnormal_immune_serum1.07293263
88MP0002752_abnormal_somatic_nervous1.05950934
89MP0002085_abnormal_embryonic_tissue1.05596791
90MP0005623_abnormal_meninges_morphology1.04810549
91MP0004134_abnormal_chest_morphology1.04490568
92MP0008873_increased_physiological_sensi1.03903136
93MP0001853_heart_inflammation1.03499584
94MP0005332_abnormal_amino_acid1.02487117
95MP0003123_paternal_imprinting1.01530964
96MP0000372_irregular_coat_pigmentation1.00519488
97MP0003861_abnormal_nervous_system1.00418242
98MP0001800_abnormal_humoral_immune1.00408346
99MP0002019_abnormal_tumor_incidence0.99735858
100MP0000653_abnormal_sex_gland0.99218994
101MP0002452_abnormal_antigen_presenting0.98041001
102MP0001697_abnormal_embryo_size0.96164823
103MP0003186_abnormal_redox_activity0.95164296
104MP0000026_abnormal_inner_ear0.94787932
105MP0000689_abnormal_spleen_morphology0.94275163
106MP0005000_abnormal_immune_tolerance0.93020658
107MP0009333_abnormal_splenocyte_physiolog0.91527280
108MP0009046_muscle_twitch0.90577132
109MP0001348_abnormal_lacrimal_gland0.90370510
110MP0001845_abnormal_inflammatory_respons0.89792250
111MP0002420_abnormal_adaptive_immunity0.89199686
112MP0003121_genomic_imprinting0.89125539
113MP0008469_abnormal_protein_level0.89014100
114MP0002736_abnormal_nociception_after0.88952404
115MP0001819_abnormal_immune_cell0.87946814
116MP0003252_abnormal_bile_duct0.86520095
117MP0002272_abnormal_nervous_system0.86030777
118MP0002080_prenatal_lethality0.85692102
119MP0005387_immune_system_phenotype0.85398468
120MP0001790_abnormal_immune_system0.85398468
121MP0003763_abnormal_thymus_physiology0.85171431
122MP0005645_abnormal_hypothalamus_physiol0.85103766
123MP0009840_abnormal_foam_cell0.84588818
124MP0000313_abnormal_cell_death0.84474776
125MP0005423_abnormal_somatic_nervous0.84068589
126MP0003632_abnormal_nervous_system0.83233732
127MP0005195_abnormal_posterior_eye0.81817671
128MP0009765_abnormal_xenobiotic_induced0.81627778
129MP0002405_respiratory_system_inflammati0.81501722
130MP0002722_abnormal_immune_system0.81219369
131MP0002161_abnormal_fertility/fecundity0.80458374
132MP0005319_abnormal_enzyme/_coenzyme0.79990558
133MP0001963_abnormal_hearing_physiology0.79772870
134MP0003755_abnormal_palate_morphology0.79506404
135MP0000716_abnormal_immune_system0.79093423
136MP0006035_abnormal_mitochondrial_morpho0.78897391
137MP0001984_abnormal_olfaction0.78523590
138MP0000703_abnormal_thymus_morphology0.77660797
139MP0003936_abnormal_reproductive_system0.77432386
140MP0002398_abnormal_bone_marrow0.76802717
141MP0000343_altered_response_to0.76211299
142MP0001672_abnormal_embryogenesis/_devel0.75832161
143MP0005380_embryogenesis_phenotype0.75832161
144MP0002111_abnormal_tail_morphology0.75600572
145MP0000427_abnormal_hair_cycle0.75114058
146MP0001299_abnormal_eye_distance/0.74327190
147MP0002429_abnormal_blood_cell0.74141314
148MP0000647_abnormal_sebaceous_gland0.73939627
149MP0005266_abnormal_metabolism0.73818711
150MP0001440_abnormal_grooming_behavior0.73081652
151MP0005394_taste/olfaction_phenotype0.72429205
152MP0005499_abnormal_olfactory_system0.72429205
153MP0006072_abnormal_retinal_apoptosis0.72232982
154MP0001542_abnormal_bone_strength0.72029957
155MP0002229_neurodegeneration0.71830129
156MP0002882_abnormal_neuron_morphology0.71662674
157MP0005636_abnormal_mineral_homeostasis0.70784376
158MP0006036_abnormal_mitochondrial_physio0.70616751
159MP0000537_abnormal_urethra_morphology0.70473591
160MP0002084_abnormal_developmental_patter0.69890573
161MP0005025_abnormal_response_to0.69760262
162MP0000762_abnormal_tongue_morphology0.69669389
163MP0002152_abnormal_brain_morphology0.69207044
164MP0001486_abnormal_startle_reflex0.67715334
165MP0002160_abnormal_reproductive_system0.67562613
166MP0002163_abnormal_gland_morphology0.66736371
167MP0003690_abnormal_glial_cell0.66524718

Predicted human phenotypes

RankGene SetZ-score
1Increased serum pyruvate (HP:0003542)5.06293796
2Abnormality of glycolysis (HP:0004366)5.06293796
3Cerebral hypomyelination (HP:0006808)4.76791713
4Breast hypoplasia (HP:0003187)3.78027849
5Acute necrotizing encephalopathy (HP:0006965)3.75141391
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.72770974
7Reticulocytopenia (HP:0001896)3.59374203
8Type I transferrin isoform profile (HP:0003642)3.53667610
9Cerebral edema (HP:0002181)3.53146328
10Increased intramyocellular lipid droplets (HP:0012240)3.50183708
11Lactic acidosis (HP:0003128)3.43764421
123-Methylglutaconic aciduria (HP:0003535)3.41342806
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.36365314
14Degeneration of the lateral corticospinal tracts (HP:0002314)3.36365314
15Parakeratosis (HP:0001036)3.32912279
16Leukodystrophy (HP:0002415)3.31231751
17Birth length less than 3rd percentile (HP:0003561)3.21484348
18Abnormal mitochondria in muscle tissue (HP:0008316)3.10629332
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.06106153
20Abnormal protein N-linked glycosylation (HP:0012347)3.06106153
21Abnormal protein glycosylation (HP:0012346)3.06106153
22Abnormal glycosylation (HP:0012345)3.06106153
23Mitochondrial inheritance (HP:0001427)3.04995766
24Hepatocellular necrosis (HP:0001404)3.02492695
25Increased muscle lipid content (HP:0009058)2.99351719
26CNS hypomyelination (HP:0003429)2.94277456
27Progressive macrocephaly (HP:0004481)2.86447654
28Increased hepatocellular lipid droplets (HP:0006565)2.86271420
29Duplicated collecting system (HP:0000081)2.84473962
30Abnormal umbilical cord blood vessels (HP:0011403)2.80643698
31Single umbilical artery (HP:0001195)2.80643698
32Abnormality of the fetal cardiovascular system (HP:0010948)2.80643698
33Increased CSF lactate (HP:0002490)2.77782110
34Adrenal hypoplasia (HP:0000835)2.71702822
35Abnormality of the labia minora (HP:0012880)2.68317659
36Absent radius (HP:0003974)2.66259888
37Acute encephalopathy (HP:0006846)2.65118086
38Methylmalonic aciduria (HP:0012120)2.63845522
39Macrocytic anemia (HP:0001972)2.61304087
40Congenital ichthyosiform erythroderma (HP:0007431)2.61274153
41Pancytopenia (HP:0001876)2.57592461
42Abnormality of the umbilical cord (HP:0010881)2.57323714
43Aplasia involving forearm bones (HP:0009822)2.54318834
44Absent forearm bone (HP:0003953)2.54318834
45Lethargy (HP:0001254)2.48996937
46Abnormality of cells of the erythroid lineage (HP:0012130)2.48901380
47CNS demyelination (HP:0007305)2.48157850
48Hypoplastic pelvis (HP:0008839)2.48154153
49Abnormality of the renal collecting system (HP:0004742)2.46518358
50Aplastic anemia (HP:0001915)2.46219722
51Microvesicular hepatic steatosis (HP:0001414)2.41483341
52Sensory axonal neuropathy (HP:0003390)2.41303538
53Reduced antithrombin III activity (HP:0001976)2.41264706
54Renal Fanconi syndrome (HP:0001994)2.40426614
55Peripheral hypomyelination (HP:0007182)2.37985112
56Alacrima (HP:0000522)2.36888564
57Patellar aplasia (HP:0006443)2.36762775
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35666436
59Methylmalonic acidemia (HP:0002912)2.32817625
60Generalized aminoaciduria (HP:0002909)2.31843240
61Abnormality of alanine metabolism (HP:0010916)2.30588817
62Hyperalaninemia (HP:0003348)2.30588817
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30588817
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.29622512
65Aplasia/Hypoplasia of the patella (HP:0006498)2.27304534
66Horseshoe kidney (HP:0000085)2.26004409
67Abnormality of the corticospinal tract (HP:0002492)2.25840370
68Degeneration of anterior horn cells (HP:0002398)2.25627797
69Abnormality of the anterior horn cell (HP:0006802)2.25627797
70Postnatal microcephaly (HP:0005484)2.24202464
71Dicarboxylic aciduria (HP:0003215)2.23871104
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23871104
73Abnormality of midbrain morphology (HP:0002418)2.22205457
74Molar tooth sign on MRI (HP:0002419)2.22205457
75Severe combined immunodeficiency (HP:0004430)2.21459747
76Lipid accumulation in hepatocytes (HP:0006561)2.20952030
77Abnormality of the septum pellucidum (HP:0007375)2.20937895
78Rough bone trabeculation (HP:0100670)2.20370911
79Respiratory difficulties (HP:0002880)2.20178013
80Increased serum lactate (HP:0002151)2.20088169
81Abnormal number of erythroid precursors (HP:0012131)2.17678559
82Hepatic necrosis (HP:0002605)2.12769811
83Pallor (HP:0000980)2.12495127
84Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11880396
85Triphalangeal thumb (HP:0001199)2.11862692
86IgG deficiency (HP:0004315)2.11491271
87Absent septum pellucidum (HP:0001331)2.11244029
88Abnormality of renal resorption (HP:0011038)2.11168788
89Spastic paraparesis (HP:0002313)2.09760442
90Carpal bone hypoplasia (HP:0001498)2.09663709
91Medial flaring of the eyebrow (HP:0010747)2.08563278
92Glycosuria (HP:0003076)2.08383557
93Abnormality of urine glucose concentration (HP:0011016)2.08383557
94Septo-optic dysplasia (HP:0100842)2.08325104
95Aplasia/Hypoplasia involving the musculature (HP:0001460)2.06921698
96Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06263435
97Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06263435
98Large for gestational age (HP:0001520)2.05307341
99Emotional lability (HP:0000712)2.05237771
100Glossoptosis (HP:0000162)2.05098574
101Supernumerary spleens (HP:0009799)2.04181714
102Morphological abnormality of the inner ear (HP:0011390)2.03816616
103Prolonged neonatal jaundice (HP:0006579)2.03144069
104Irregular epiphyses (HP:0010582)2.00172635
105Decreased lacrimation (HP:0000633)1.97571753
106Abnormalities of placenta or umbilical cord (HP:0001194)1.97324961
107Multiple enchondromatosis (HP:0005701)1.97118632
108Progressive microcephaly (HP:0000253)1.96412165
109Chromsome breakage (HP:0040012)1.95565533
110Ureteral duplication (HP:0000073)1.94150977
111Duplication of thumb phalanx (HP:0009942)1.92630826
112Cleft eyelid (HP:0000625)1.92152982
113Combined immunodeficiency (HP:0005387)1.91941648
114Aplasia/hypoplasia of the uterus (HP:0008684)1.91412751
115Pancreatic cysts (HP:0001737)1.90907481
116Autoamputation (HP:0001218)1.90724581
117Conical tooth (HP:0000698)1.88642291
118Gait imbalance (HP:0002141)1.87510530
119Absent thumb (HP:0009777)1.86791010
120Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86324230
121Oral leukoplakia (HP:0002745)1.85641138
122Aplasia/Hypoplasia of the uvula (HP:0010293)1.85305841
123Opisthotonus (HP:0002179)1.85241895
124Premature graying of hair (HP:0002216)1.83991167
125Abnormality of the preputium (HP:0100587)1.83804820
126Trismus (HP:0000211)1.83510200
127Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82917445
128Abnormality of B cell number (HP:0010975)1.82710209
129Anencephaly (HP:0002323)1.82055944
130Respiratory failure (HP:0002878)1.81540372
131Pancreatic fibrosis (HP:0100732)1.81446803
132Congenital primary aphakia (HP:0007707)1.81404221
133B lymphocytopenia (HP:0010976)1.80162457
134Stenosis of the external auditory canal (HP:0000402)1.80029366
135Optic disc pallor (HP:0000543)1.79836257
136Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79546061
137Microretrognathia (HP:0000308)1.79264338
138Spastic gait (HP:0002064)1.78277657
139Meckel diverticulum (HP:0002245)1.78225114
140Nemaline bodies (HP:0003798)1.76967822
141Exercise intolerance (HP:0003546)1.76017219
142Abnormal lung lobation (HP:0002101)1.75569824
143Exertional dyspnea (HP:0002875)1.74835888
144Testicular atrophy (HP:0000029)1.74279513
145Renal cortical cysts (HP:0000803)1.74195966
146Thyroiditis (HP:0100646)1.73508222
147Abnormal trabecular bone morphology (HP:0100671)1.73179017
148Vacuolated lymphocytes (HP:0001922)1.72882186
149Abnormality of methionine metabolism (HP:0010901)1.72638383
150Type 2 muscle fiber atrophy (HP:0003554)1.72297260
151Seborrheic dermatitis (HP:0001051)1.72286093
152Type II lissencephaly (HP:0007260)1.70072356
153Amniotic constriction ring (HP:0009775)1.69300193
154Hypoplasia of the uterus (HP:0000013)1.69054862
155Abnormality of the ileum (HP:0001549)1.68621987
156Neutropenia (HP:0001875)1.67684437
157Ketoacidosis (HP:0001993)1.66117926
158Abnormality of T cell physiology (HP:0011840)1.65873663
159X-linked dominant inheritance (HP:0001423)1.64493064
160Ketosis (HP:0001946)1.62135261
161Congenital, generalized hypertrichosis (HP:0004540)1.61356601
162Gliosis (HP:0002171)1.60841458
163Blindness (HP:0000618)1.60760017
164Abnormality of T cells (HP:0002843)1.60124868
165Muscle fiber atrophy (HP:0100295)1.58098383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.74789203
2VRK24.03598417
3WEE13.42434123
4PBK3.11509311
5STK393.10157910
6LIMK13.06403213
7STK162.99274151
8BCKDK2.98125542
9ZAK2.93902702
10TESK22.92283307
11EIF2AK12.76851368
12SRPK12.35157915
13MAP4K22.21519109
14MAP3K122.18964714
15PNCK2.17728632
16TLK12.15960497
17MKNK12.14688041
18CAMKK22.07108029
19OXSR12.06121250
20NME21.96878431
21NUAK11.96310492
22EIF2AK31.88091560
23BCR1.88087927
24PLK41.76959675
25DYRK21.76227558
26TRIM281.73178772
27MST41.72471644
28CDK191.67122479
29FRK1.65427933
30TSSK61.65077031
31CDC71.64868936
32NME11.57272187
33CSNK1G31.54253039
34VRK11.54178627
35KDR1.43458926
36ADRBK21.43303385
37TXK1.39737409
38MAPKAPK51.37054541
39CCNB11.31846513
40TESK11.31830991
41BMPR1B1.29941274
42CDK81.26528845
43CAMK1D1.23750657
44MAP2K71.22473668
45PLK31.19535649
46CSNK1G11.19174043
47PKN11.15899682
48ACVR1B1.15883107
49TAF11.14889447
50DAPK11.13547055
51PLK11.13473145
52BRSK21.10810336
53CSNK1A1L1.10318644
54DYRK31.06113922
55AURKA1.04709170
56ARAF1.03782244
57SCYL20.99958020
58IKBKB0.98808410
59MET0.98455623
60WNK40.98207634
61MKNK20.96436643
62GRK10.96105994
63UHMK10.95670266
64TTK0.95594200
65CASK0.94495003
66PAK10.90420785
67TNIK0.85488598
68GRK70.83766049
69AURKB0.83026393
70MARK10.79542882
71BRAF0.79503173
72CSNK1G20.77118494
73INSRR0.75775788
74MAP3K80.75139640
75CAMK1G0.74760285
76FGFR20.71666544
77BRSK10.71427479
78CHEK20.71352901
79RPS6KA50.70002624
80CDK140.68698032
81MAPKAPK30.67897743
82EIF2AK20.67643177
83CDK70.67280645
84NEK60.66985697
85ROCK20.66239451
86WNK30.65962509
87NEK20.65690469
88ATR0.63454252
89CAMK2B0.63023390
90DAPK30.62887723
91PLK20.62115448
92TYRO30.61456239
93STK100.60791250
94MAP3K40.59327622
95* CHEK10.58310712
96IRAK30.58166759
97CDK11A0.57968450
98CDK150.57409303
99CDK180.56973395
100YES10.56873123
101RPS6KB20.56192322
102CSNK2A20.55538156
103MYLK0.53119548
104ERBB30.52869975
105CLK10.51504307
106EPHB10.51197984
107CSNK2A10.51092500
108PIM20.50852110
109ABL20.48543487
110PRKCI0.47449051
111MAPK130.45511513
112MAP2K20.44788547
113TBK10.42839118
114LRRK20.40236744
115NTRK20.40068334
116PAK40.39450545
117BMPR20.39006508
118MAP3K110.38996183
119CDK10.37508497
120CDK20.36582692
121ILK0.35730785
122PDK40.35590939
123PDK30.35590939
124ADRBK10.35490046
125PDK20.33471017
126FGR0.32488982
127CSNK1A10.31861874
128TAOK30.31333841
129CDK90.31241413
130CAMK2D0.29815304
131PIM10.29500132
132MAP3K30.29287984
133NEK10.29278066
134GRK50.28199636
135ICK0.28030829
136STK40.27874583
137CAMK2G0.26429906
138CSNK1E0.26421361
139IKBKE0.25573904
140IRAK40.25107706
141FES0.24805705
142GRK60.24302516
143ATM0.24194627
144FER0.22565335
145MAP3K50.22340604

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.03270940
2RNA polymerase_Homo sapiens_hsa030204.14176659
3Ribosome_Homo sapiens_hsa030103.86216535
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.64421857
5DNA replication_Homo sapiens_hsa030303.19484586
6Mismatch repair_Homo sapiens_hsa034302.93371070
7Spliceosome_Homo sapiens_hsa030402.91001575
8Oxidative phosphorylation_Homo sapiens_hsa001902.75220267
9* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73876148
10Homologous recombination_Homo sapiens_hsa034402.48048849
11Basal transcription factors_Homo sapiens_hsa030222.35620401
12Parkinsons disease_Homo sapiens_hsa050122.35414070
13* RNA transport_Homo sapiens_hsa030132.28617959
14Nucleotide excision repair_Homo sapiens_hsa034202.24546158
15Pyrimidine metabolism_Homo sapiens_hsa002402.22495054
16Steroid biosynthesis_Homo sapiens_hsa001002.20234949
17Huntingtons disease_Homo sapiens_hsa050161.96517604
18Cell cycle_Homo sapiens_hsa041101.84976244
19Protein export_Homo sapiens_hsa030601.82964323
20Non-homologous end-joining_Homo sapiens_hsa034501.72781047
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71608031
22Fanconi anemia pathway_Homo sapiens_hsa034601.67809153
23Base excision repair_Homo sapiens_hsa034101.65773841
24Vitamin B6 metabolism_Homo sapiens_hsa007501.64660316
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.61811289
26Sulfur metabolism_Homo sapiens_hsa009201.59982290
27Alzheimers disease_Homo sapiens_hsa050101.50855411
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50781297
29Fatty acid elongation_Homo sapiens_hsa000621.44835076
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38082639
31RNA degradation_Homo sapiens_hsa030181.36954278
32Purine metabolism_Homo sapiens_hsa002301.31503186
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30190967
34Ether lipid metabolism_Homo sapiens_hsa005651.28925034
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28798820
36Glutathione metabolism_Homo sapiens_hsa004801.25172904
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21673547
38mRNA surveillance pathway_Homo sapiens_hsa030151.20408189
39Epstein-Barr virus infection_Homo sapiens_hsa051691.19308761
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18398763
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08428034
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07141930
43Propanoate metabolism_Homo sapiens_hsa006400.99291551
44Caffeine metabolism_Homo sapiens_hsa002320.96615773
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95666938
46Peroxisome_Homo sapiens_hsa041460.95365501
47Selenocompound metabolism_Homo sapiens_hsa004500.88446306
48Regulation of autophagy_Homo sapiens_hsa041400.88150061
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87786839
50N-Glycan biosynthesis_Homo sapiens_hsa005100.80566794
51Butanoate metabolism_Homo sapiens_hsa006500.77692022
52Systemic lupus erythematosus_Homo sapiens_hsa053220.76766419
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.74916830
54Arachidonic acid metabolism_Homo sapiens_hsa005900.74026982
55Linoleic acid metabolism_Homo sapiens_hsa005910.73450436
56One carbon pool by folate_Homo sapiens_hsa006700.73095584
57Oocyte meiosis_Homo sapiens_hsa041140.72382613
58Pentose phosphate pathway_Homo sapiens_hsa000300.70609471
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70169174
60Antigen processing and presentation_Homo sapiens_hsa046120.66085307
61p53 signaling pathway_Homo sapiens_hsa041150.63947549
62Tryptophan metabolism_Homo sapiens_hsa003800.62115842
63Autoimmune thyroid disease_Homo sapiens_hsa053200.61088824
64Collecting duct acid secretion_Homo sapiens_hsa049660.59222809
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56845915
66Cardiac muscle contraction_Homo sapiens_hsa042600.56443316
67Sphingolipid metabolism_Homo sapiens_hsa006000.55221990
68Metabolic pathways_Homo sapiens_hsa011000.55117568
69Folate biosynthesis_Homo sapiens_hsa007900.52368554
70Type I diabetes mellitus_Homo sapiens_hsa049400.52072861
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50830182
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50619470
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50357718
74Shigellosis_Homo sapiens_hsa051310.48736984
75Graft-versus-host disease_Homo sapiens_hsa053320.48423741
76Viral carcinogenesis_Homo sapiens_hsa052030.47512602
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46774010
78Axon guidance_Homo sapiens_hsa043600.46306000
79Rheumatoid arthritis_Homo sapiens_hsa053230.46234516
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45601566
81Basal cell carcinoma_Homo sapiens_hsa052170.45024698
82Sulfur relay system_Homo sapiens_hsa041220.44796300
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.44430612
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42964549
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.42709278
86Hedgehog signaling pathway_Homo sapiens_hsa043400.41627543
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41399320
88Chemical carcinogenesis_Homo sapiens_hsa052040.40850783
89Allograft rejection_Homo sapiens_hsa053300.40540474
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40530794
91Phenylalanine metabolism_Homo sapiens_hsa003600.40155027
92Arginine and proline metabolism_Homo sapiens_hsa003300.38497265
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37685758
94Tight junction_Homo sapiens_hsa045300.36091159
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35779421
96Asthma_Homo sapiens_hsa053100.35630859
97Alcoholism_Homo sapiens_hsa050340.35018952
98Biosynthesis of amino acids_Homo sapiens_hsa012300.34648013
99Phagosome_Homo sapiens_hsa041450.33682896
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33542737
101Pyruvate metabolism_Homo sapiens_hsa006200.32694874
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31683596
103Phototransduction_Homo sapiens_hsa047440.31587244
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30978853
105Lysosome_Homo sapiens_hsa041420.29823420
106Vibrio cholerae infection_Homo sapiens_hsa051100.29652962
107Galactose metabolism_Homo sapiens_hsa000520.29453818
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28488062
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28305194
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28162808
111Hippo signaling pathway_Homo sapiens_hsa043900.27999280
112Tyrosine metabolism_Homo sapiens_hsa003500.27906310
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27797312
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26225206
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25628348
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24995321
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.24824644
118Renal cell carcinoma_Homo sapiens_hsa052110.23880517
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23281008
120Herpes simplex infection_Homo sapiens_hsa051680.18330306
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.16873520
122Carbon metabolism_Homo sapiens_hsa012000.15568830
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.13615096
124HTLV-I infection_Homo sapiens_hsa051660.13460690
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.12451892
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.10689745
127Primary immunodeficiency_Homo sapiens_hsa053400.09596130
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.07324649
129Endocytosis_Homo sapiens_hsa041440.06258727
130Malaria_Homo sapiens_hsa051440.05352079
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.03901843
132MicroRNAs in cancer_Homo sapiens_hsa052060.03401943
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.02800778
134Legionellosis_Homo sapiens_hsa051340.02774982

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