

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 6.50770950 |
| 2 | peptidyl-histidine modification (GO:0018202) | 6.18608546 |
| 3 | ribosomal small subunit assembly (GO:0000028) | 6.02232721 |
| 4 | viral transcription (GO:0019083) | 5.83284895 |
| 5 | translational termination (GO:0006415) | 5.67900281 |
| 6 | maturation of SSU-rRNA (GO:0030490) | 5.65506958 |
| 7 | ribosomal small subunit biogenesis (GO:0042274) | 5.46733873 |
| 8 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.19988495 |
| 9 | translational elongation (GO:0006414) | 5.18016924 |
| 10 | cotranslational protein targeting to membrane (GO:0006613) | 5.08747446 |
| 11 | protein targeting to ER (GO:0045047) | 5.07237731 |
| 12 | ribosomal large subunit biogenesis (GO:0042273) | 4.86762114 |
| 13 | protein localization to endoplasmic reticulum (GO:0070972) | 4.84576852 |
| 14 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.81518276 |
| 15 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.79957751 |
| 16 | translational initiation (GO:0006413) | 4.68329435 |
| 17 | proteasome assembly (GO:0043248) | 4.64604001 |
| 18 | cellular protein complex disassembly (GO:0043624) | 4.51620114 |
| 19 | viral life cycle (GO:0019058) | 4.48314162 |
| 20 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.42080695 |
| 21 | ATP synthesis coupled proton transport (GO:0015986) | 4.42080695 |
| 22 | formation of translation preinitiation complex (GO:0001731) | 4.38646246 |
| 23 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.35807535 |
| 24 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.35191176 |
| 25 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.28139322 |
| 26 | regulation of mitochondrial translation (GO:0070129) | 4.27077854 |
| 27 | translation (GO:0006412) | 4.25556653 |
| 28 | cytochrome complex assembly (GO:0017004) | 4.18527557 |
| 29 | respiratory chain complex IV assembly (GO:0008535) | 4.13209661 |
| 30 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.06416672 |
| 31 | oxidative phosphorylation (GO:0006119) | 3.99579726 |
| 32 | termination of RNA polymerase III transcription (GO:0006386) | 3.97944432 |
| 33 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.97944432 |
| 34 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.94869520 |
| 35 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.89226647 |
| 36 | protein complex disassembly (GO:0043241) | 3.87256794 |
| 37 | nucleobase biosynthetic process (GO:0046112) | 3.86656474 |
| 38 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.83926165 |
| 39 | cellular component biogenesis (GO:0044085) | 3.81774580 |
| 40 | purine nucleobase biosynthetic process (GO:0009113) | 3.79196402 |
| 41 | macromolecular complex disassembly (GO:0032984) | 3.75444775 |
| 42 | rRNA modification (GO:0000154) | 3.74611822 |
| 43 | DNA double-strand break processing (GO:0000729) | 3.72547202 |
| 44 | ribosome biogenesis (GO:0042254) | 3.71055834 |
| 45 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.66542130 |
| 46 | pseudouridine synthesis (GO:0001522) | 3.66298508 |
| 47 | rRNA processing (GO:0006364) | 3.64947685 |
| 48 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.62705425 |
| 49 | kinetochore organization (GO:0051383) | 3.59896310 |
| 50 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.54286607 |
| 51 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.54100606 |
| 52 | rRNA metabolic process (GO:0016072) | 3.52687675 |
| 53 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.52468821 |
| 54 | respiratory electron transport chain (GO:0022904) | 3.49428810 |
| 55 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.47079320 |
| 56 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.47027938 |
| 57 | negative regulation of ligase activity (GO:0051352) | 3.47027938 |
| 58 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.46203378 |
| 59 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.46135132 |
| 60 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.45713249 |
| 61 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.43875358 |
| 62 | electron transport chain (GO:0022900) | 3.43462671 |
| 63 | cullin deneddylation (GO:0010388) | 3.43292479 |
| 64 | spliceosomal snRNP assembly (GO:0000387) | 3.41978864 |
| 65 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.41104635 |
| 66 | chaperone-mediated protein transport (GO:0072321) | 3.40959010 |
| 67 | intra-S DNA damage checkpoint (GO:0031573) | 3.38666191 |
| 68 | maturation of 5.8S rRNA (GO:0000460) | 3.38542614 |
| 69 | protein targeting to membrane (GO:0006612) | 3.37595239 |
| 70 | chromatin remodeling at centromere (GO:0031055) | 3.37354085 |
| 71 | iron-sulfur cluster assembly (GO:0016226) | 3.34770061 |
| 72 | metallo-sulfur cluster assembly (GO:0031163) | 3.34770061 |
| 73 | folic acid metabolic process (GO:0046655) | 3.34697468 |
| 74 | protein targeting to mitochondrion (GO:0006626) | 3.33190704 |
| 75 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.32856776 |
| 76 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.32856776 |
| 77 | DNA strand elongation (GO:0022616) | 3.32853154 |
| 78 | establishment of protein localization to mitochondrion (GO:0072655) | 3.31565083 |
| 79 | meiotic chromosome segregation (GO:0045132) | 3.30000661 |
| 80 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.29211765 |
| 81 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.28036236 |
| 82 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.25098102 |
| 83 | CENP-A containing nucleosome assembly (GO:0034080) | 3.24760995 |
| 84 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.20511652 |
| 85 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.20511652 |
| 86 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.19710065 |
| 87 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.19710065 |
| 88 | amino acid salvage (GO:0043102) | 3.19458691 |
| 89 | L-methionine salvage (GO:0071267) | 3.19458691 |
| 90 | L-methionine biosynthetic process (GO:0071265) | 3.19458691 |
| 91 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.19419508 |
| 92 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.19419508 |
| 93 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.19419508 |
| 94 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.18984648 |
| 95 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.18971717 |
| 96 | NADH dehydrogenase complex assembly (GO:0010257) | 3.18971717 |
| 97 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.18971717 |
| 98 | protein complex biogenesis (GO:0070271) | 3.17581849 |
| 99 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.17444149 |
| 100 | protein neddylation (GO:0045116) | 3.16315241 |
| 101 | establishment of integrated proviral latency (GO:0075713) | 3.14593143 |
| 102 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.14075689 |
| 103 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.14028507 |
| 104 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.14028507 |
| 105 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.13678103 |
| 106 | ribosome assembly (GO:0042255) | 3.13314961 |
| 107 | rRNA methylation (GO:0031167) | 3.10662659 |
| 108 | 7-methylguanosine mRNA capping (GO:0006370) | 3.09823542 |
| 109 | protein deneddylation (GO:0000338) | 3.09367323 |
| 110 | mRNA catabolic process (GO:0006402) | 3.09361795 |
| 111 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.08600340 |
| 112 | GDP-mannose metabolic process (GO:0019673) | 3.08414925 |
| 113 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.07966319 |
| 114 | positive regulation of ligase activity (GO:0051351) | 3.07955994 |
| 115 | DNA ligation (GO:0006266) | 3.07910892 |
| 116 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.07079070 |
| 117 | protein localization to mitochondrion (GO:0070585) | 3.06258889 |
| 118 | DNA replication checkpoint (GO:0000076) | 3.05587755 |
| 119 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.03599133 |
| 120 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.03599133 |
| 121 | kinetochore assembly (GO:0051382) | 3.03061581 |
| 122 | GMP metabolic process (GO:0046037) | 3.01934473 |
| 123 | inner mitochondrial membrane organization (GO:0007007) | 3.00858239 |
| 124 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.00338559 |
| 125 | 7-methylguanosine RNA capping (GO:0009452) | 3.00089524 |
| 126 | RNA capping (GO:0036260) | 3.00089524 |
| 127 | fucose catabolic process (GO:0019317) | 2.97171082 |
| 128 | L-fucose metabolic process (GO:0042354) | 2.97171082 |
| 129 | L-fucose catabolic process (GO:0042355) | 2.97171082 |
| 130 | cytidine deamination (GO:0009972) | 2.95293089 |
| 131 | cytidine metabolic process (GO:0046087) | 2.95293089 |
| 132 | cytidine catabolic process (GO:0006216) | 2.95293089 |
| 133 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.95105280 |
| 134 | regulation of Wnt signaling pathway involved in heart development (GO:0003307) | 2.93783572 |
| 135 | intracellular protein transmembrane import (GO:0044743) | 2.91189500 |
| 136 | ATP biosynthetic process (GO:0006754) | 2.90275728 |
| 137 | protein-cofactor linkage (GO:0018065) | 2.90052026 |
| 138 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.88558809 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.38926625 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.33443053 |
| 3 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.24361350 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.87664049 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.69235077 |
| 6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.65997470 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.49656693 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.41062088 |
| 9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.20301847 |
| 10 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.18626037 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.95321675 |
| 12 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.87530071 |
| 13 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.79721329 |
| 14 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.78596745 |
| 15 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.65701647 |
| 16 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.53976737 |
| 17 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.48237888 |
| 18 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.45722921 |
| 19 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.35498893 |
| 20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.35042078 |
| 21 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.33959482 |
| 22 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.33201282 |
| 23 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.29958099 |
| 24 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.19214625 |
| 25 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.12905569 |
| 26 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.10440953 |
| 27 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.07234196 |
| 28 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.02980922 |
| 29 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.02906690 |
| 30 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.98546391 |
| 31 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.97807202 |
| 32 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.96601206 |
| 33 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.94300402 |
| 34 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.93394456 |
| 35 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.90121453 |
| 36 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.88637552 |
| 37 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.84062257 |
| 38 | VDR_22108803_ChIP-Seq_LS180_Human | 1.78323052 |
| 39 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.76983949 |
| 40 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.70538912 |
| 41 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.69291172 |
| 42 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.68521641 |
| 43 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.66370463 |
| 44 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.63329496 |
| 45 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.62801656 |
| 46 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.61831750 |
| 47 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.60758324 |
| 48 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.58582183 |
| 49 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.54459282 |
| 50 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.53255535 |
| 51 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.51519497 |
| 52 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.49691660 |
| 53 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.48419730 |
| 54 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.45275426 |
| 55 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 1.42402098 |
| 56 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.40066132 |
| 57 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.39126550 |
| 58 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.38754195 |
| 59 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.37867022 |
| 60 | EWS_26573619_Chip-Seq_HEK293_Human | 1.37820139 |
| 61 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.37707650 |
| 62 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.37660283 |
| 63 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.37180798 |
| 64 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.35249929 |
| 65 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.32223186 |
| 66 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.30541091 |
| 67 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.27410198 |
| 68 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.26476422 |
| 69 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.23554885 |
| 70 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.23136900 |
| 71 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.22412934 |
| 72 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.22024856 |
| 73 | FUS_26573619_Chip-Seq_HEK293_Human | 1.21892289 |
| 74 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.20775517 |
| 75 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.19519905 |
| 76 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.18717022 |
| 77 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.18490102 |
| 78 | * HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.17589915 |
| 79 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.17509465 |
| 80 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.15882774 |
| 81 | * CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.15718654 |
| 82 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.14092114 |
| 83 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.13692046 |
| 84 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.13363938 |
| 85 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.13210267 |
| 86 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.12421168 |
| 87 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.11792810 |
| 88 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.11516388 |
| 89 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.05777717 |
| 90 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.04720703 |
| 91 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.03272657 |
| 92 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.02442306 |
| 93 | * MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.02027766 |
| 94 | * MYC_18940864_ChIP-ChIP_HL60_Human | 1.00563419 |
| 95 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.99794444 |
| 96 | MYC_22102868_ChIP-Seq_BL_Human | 0.98406586 |
| 97 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.97442440 |
| 98 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.97338462 |
| 99 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.96694675 |
| 100 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.96315396 |
| 101 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.95745418 |
| 102 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.95175804 |
| 103 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.94444519 |
| 104 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.94333119 |
| 105 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.93509915 |
| 106 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.91678157 |
| 107 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.91596414 |
| 108 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.91586636 |
| 109 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.88476909 |
| 110 | * GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.86807823 |
| 111 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.86667363 |
| 112 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.86506199 |
| 113 | GATA1_22025678_ChIP-Seq_K562_Human | 0.85323955 |
| 114 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.84936564 |
| 115 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84727070 |
| 116 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.83596958 |
| 117 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.82773047 |
| 118 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.79356876 |
| 119 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.79349760 |
| 120 | AR_20517297_ChIP-Seq_VCAP_Human | 0.78823593 |
| 121 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.78536243 |
| 122 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.78536243 |
| 123 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.76453445 |
| 124 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.74604906 |
| 125 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.70795183 |
| 126 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.70730901 |
| 127 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.70334035 |
| 128 | P300_19829295_ChIP-Seq_ESCs_Human | 0.68542797 |
| 129 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.67303550 |
| 130 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.67145908 |
| 131 | NCOR_22424771_ChIP-Seq_293T_Human | 0.65515259 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.38556944 |
| 2 | MP0003806_abnormal_nucleotide_metabolis | 4.11995126 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.01562584 |
| 4 | MP0002234_abnormal_pharynx_morphology | 3.82796280 |
| 5 | MP0009379_abnormal_foot_pigmentation | 3.71107839 |
| 6 | MP0006036_abnormal_mitochondrial_physio | 3.04168567 |
| 7 | MP0003111_abnormal_nucleus_morphology | 2.83006529 |
| 8 | MP0010094_abnormal_chromosome_stability | 2.74369686 |
| 9 | MP0003077_abnormal_cell_cycle | 2.59100480 |
| 10 | MP0001873_stomach_inflammation | 2.57662378 |
| 11 | MP0005360_urolithiasis | 2.56197923 |
| 12 | MP0002139_abnormal_hepatobiliary_system | 2.56074589 |
| 13 | MP0003186_abnormal_redox_activity | 2.51868348 |
| 14 | MP0006072_abnormal_retinal_apoptosis | 2.37928157 |
| 15 | MP0006035_abnormal_mitochondrial_morpho | 2.22067616 |
| 16 | MP0008932_abnormal_embryonic_tissue | 2.20010113 |
| 17 | MP0001986_abnormal_taste_sensitivity | 2.16994507 |
| 18 | MP0008058_abnormal_DNA_repair | 2.16580126 |
| 19 | MP0004147_increased_porphyrin_level | 2.13532790 |
| 20 | MP0003123_paternal_imprinting | 2.12743897 |
| 21 | MP0002837_dystrophic_cardiac_calcinosis | 2.06676294 |
| 22 | MP0003656_abnormal_erythrocyte_physiolo | 1.98733612 |
| 23 | MP0001764_abnormal_homeostasis | 1.98167253 |
| 24 | MP0003718_maternal_effect | 1.96056498 |
| 25 | MP0005085_abnormal_gallbladder_physiolo | 1.94391864 |
| 26 | MP0003763_abnormal_thymus_physiology | 1.94042545 |
| 27 | MP0000372_irregular_coat_pigmentation | 1.91626270 |
| 28 | MP0005332_abnormal_amino_acid | 1.87418817 |
| 29 | MP0008961_abnormal_basal_metabolism | 1.86497677 |
| 30 | MP0005365_abnormal_bile_salt | 1.86005375 |
| 31 | MP0002938_white_spotting | 1.81364289 |
| 32 | MP0003786_premature_aging | 1.80578968 |
| 33 | MP0009333_abnormal_splenocyte_physiolog | 1.72192688 |
| 34 | MP0005083_abnormal_biliary_tract | 1.68729778 |
| 35 | MP0005636_abnormal_mineral_homeostasis | 1.65631038 |
| 36 | MP0009840_abnormal_foam_cell | 1.54578044 |
| 37 | MP0001730_embryonic_growth_arrest | 1.53624827 |
| 38 | MP0005084_abnormal_gallbladder_morpholo | 1.49570784 |
| 39 | MP0005075_abnormal_melanosome_morpholog | 1.48865734 |
| 40 | MP0009643_abnormal_urine_homeostasis | 1.46796851 |
| 41 | MP0008789_abnormal_olfactory_epithelium | 1.46707940 |
| 42 | MP0002653_abnormal_ependyma_morphology | 1.45955903 |
| 43 | MP0002735_abnormal_chemical_nociception | 1.45330576 |
| 44 | MP0003011_delayed_dark_adaptation | 1.45162373 |
| 45 | MP0002102_abnormal_ear_morphology | 1.43710993 |
| 46 | MP0003646_muscle_fatigue | 1.41372373 |
| 47 | MP0005551_abnormal_eye_electrophysiolog | 1.41199656 |
| 48 | MP0002396_abnormal_hematopoietic_system | 1.39361236 |
| 49 | MP0000358_abnormal_cell_content/ | 1.34946113 |
| 50 | MP0005253_abnormal_eye_physiology | 1.34354154 |
| 51 | MP0002132_abnormal_respiratory_system | 1.33736090 |
| 52 | MP0008057_abnormal_DNA_replication | 1.32485667 |
| 53 | MP0008007_abnormal_cellular_replicative | 1.31062731 |
| 54 | MP0008875_abnormal_xenobiotic_pharmacok | 1.29689851 |
| 55 | MP0002160_abnormal_reproductive_system | 1.27947488 |
| 56 | MP0001756_abnormal_urination | 1.24404628 |
| 57 | MP0002277_abnormal_respiratory_mucosa | 1.23820320 |
| 58 | MP0002736_abnormal_nociception_after | 1.23670067 |
| 59 | MP0002090_abnormal_vision | 1.21870380 |
| 60 | MP0001968_abnormal_touch/_nociception | 1.21631588 |
| 61 | MP0000490_abnormal_crypts_of | 1.18959182 |
| 62 | MP0004043_abnormal_pH_regulation | 1.18597123 |
| 63 | MP0005319_abnormal_enzyme/_coenzyme | 1.15411233 |
| 64 | MP0008872_abnormal_physiological_respon | 1.13969308 |
| 65 | MP0001853_heart_inflammation | 1.11393564 |
| 66 | MP0002019_abnormal_tumor_incidence | 1.08453371 |
| 67 | MP0002210_abnormal_sex_determination | 1.08127398 |
| 68 | MP0000313_abnormal_cell_death | 1.07869122 |
| 69 | MP0004145_abnormal_muscle_electrophysio | 1.07792183 |
| 70 | MP0005389_reproductive_system_phenotype | 1.06763062 |
| 71 | MP0003195_calcinosis | 1.06497719 |
| 72 | MP0002163_abnormal_gland_morphology | 1.06258936 |
| 73 | MP0001929_abnormal_gametogenesis | 1.04826931 |
| 74 | MP0002722_abnormal_immune_system | 1.04690451 |
| 75 | MP0008995_early_reproductive_senescence | 1.03607831 |
| 76 | MP0002080_prenatal_lethality | 1.03205864 |
| 77 | MP0001666_abnormal_nutrient_absorption | 1.00357078 |
| 78 | MP0000350_abnormal_cell_proliferation | 1.00210829 |
| 79 | MP0001529_abnormal_vocalization | 0.98498651 |
| 80 | MP0000689_abnormal_spleen_morphology | 0.97286513 |
| 81 | MP0006276_abnormal_autonomic_nervous | 0.95921942 |
| 82 | MP0003787_abnormal_imprinting | 0.92483457 |
| 83 | MP0000653_abnormal_sex_gland | 0.92387567 |
| 84 | MP0000609_abnormal_liver_physiology | 0.91949737 |
| 85 | MP0004019_abnormal_vitamin_homeostasis | 0.91933264 |
| 86 | MP0009046_muscle_twitch | 0.91098768 |
| 87 | MP0003136_yellow_coat_color | 0.91015932 |
| 88 | MP0005645_abnormal_hypothalamus_physiol | 0.90204066 |
| 89 | MP0005671_abnormal_response_to | 0.89576955 |
| 90 | MP0000703_abnormal_thymus_morphology | 0.89528125 |
| 91 | MP0002398_abnormal_bone_marrow | 0.89522773 |
| 92 | MP0001697_abnormal_embryo_size | 0.89059435 |
| 93 | MP0005266_abnormal_metabolism | 0.88839149 |
| 94 | MP0003866_abnormal_defecation | 0.88212418 |
| 95 | MP0001145_abnormal_male_reproductive | 0.88121705 |
| 96 | MP0005670_abnormal_white_adipose | 0.86516125 |
| 97 | MP0001346_abnormal_lacrimal_gland | 0.85852892 |
| 98 | MP0001919_abnormal_reproductive_system | 0.85517180 |
| 99 | MP0008877_abnormal_DNA_methylation | 0.85357905 |
| 100 | MP0005410_abnormal_fertilization | 0.85153618 |
| 101 | MP0000598_abnormal_liver_morphology | 0.83968120 |
| 102 | MP0002876_abnormal_thyroid_physiology | 0.83557623 |
| 103 | MP0005408_hypopigmentation | 0.83437260 |
| 104 | MP0005397_hematopoietic_system_phenotyp | 0.82323742 |
| 105 | MP0001545_abnormal_hematopoietic_system | 0.82323742 |
| 106 | MP0010386_abnormal_urinary_bladder | 0.80887372 |
| 107 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.80216532 |
| 108 | MP0001119_abnormal_female_reproductive | 0.79939656 |
| 109 | MP0009697_abnormal_copulation | 0.79183111 |
| 110 | MP0006292_abnormal_olfactory_placode | 0.79146961 |
| 111 | MP0001485_abnormal_pinna_reflex | 0.79076570 |
| 112 | MP0001905_abnormal_dopamine_level | 0.78854505 |
| 113 | MP0002638_abnormal_pupillary_reflex | 0.78328654 |
| 114 | MP0005220_abnormal_exocrine_pancreas | 0.78318250 |
| 115 | MP0003191_abnormal_cellular_cholesterol | 0.78162766 |
| 116 | MP0002429_abnormal_blood_cell | 0.77108084 |
| 117 | MP0001293_anophthalmia | 0.76912337 |
| 118 | MP0005174_abnormal_tail_pigmentation | 0.76098568 |
| 119 | MP0003698_abnormal_male_reproductive | 0.74909193 |
| 120 | MP0005379_endocrine/exocrine_gland_phen | 0.74510845 |
| 121 | MP0000631_abnormal_neuroendocrine_gland | 0.73945217 |
| 122 | MP0004215_abnormal_myocardial_fiber | 0.73859243 |
| 123 | MP0005394_taste/olfaction_phenotype | 0.73853970 |
| 124 | MP0005499_abnormal_olfactory_system | 0.73853970 |
| 125 | MP0010307_abnormal_tumor_latency | 0.73627306 |
| 126 | MP0003567_abnormal_fetal_cardiomyocyte | 0.69374980 |
| 127 | MP0004133_heterotaxia | 0.68640022 |
| 128 | MP0003638_abnormal_response/metabolism_ | 0.68515475 |
| 129 | MP0002138_abnormal_hepatobiliary_system | 0.67971184 |
| 130 | MP0008260_abnormal_autophagy | 0.67161954 |
| 131 | MP0002928_abnormal_bile_duct | 0.67043141 |
| 132 | MP0005376_homeostasis/metabolism_phenot | 0.66494940 |
| 133 | MP0002751_abnormal_autonomic_nervous | 0.66452799 |
| 134 | MP0003315_abnormal_perineum_morphology | 0.64729416 |
| 135 | MP0010329_abnormal_lipoprotein_level | 0.64298538 |
| 136 | MP0008469_abnormal_protein_level | 0.64134017 |
| 137 | MP0002095_abnormal_skin_pigmentation | 0.63155094 |
| 138 | MP0005380_embryogenesis_phenotype | 0.63120875 |
| 139 | MP0001672_abnormal_embryogenesis/_devel | 0.63120875 |
| 140 | MP0005195_abnormal_posterior_eye | 0.61917872 |
| 141 | MP0001727_abnormal_embryo_implantation | 0.61773312 |
| 142 | MP0002136_abnormal_kidney_physiology | 0.61275955 |
| 143 | MP0001661_extended_life_span | 0.61043634 |
| 144 | MP0001944_abnormal_pancreas_morphology | 0.60873364 |
| 145 | MP0000858_altered_metastatic_potential | 0.59894850 |
| 146 | MP0008873_increased_physiological_sensi | 0.59472163 |
| 147 | MP0004142_abnormal_muscle_tone | 0.58101764 |
| 148 | MP0009764_decreased_sensitivity_to | 0.57688283 |
| 149 | MP0003937_abnormal_limbs/digits/tail_de | 0.57019228 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.54127653 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 5.31631379 |
| 3 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.88714501 |
| 4 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.88714501 |
| 5 | Acute necrotizing encephalopathy (HP:0006965) | 4.49536520 |
| 6 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.27310994 |
| 7 | Hepatic necrosis (HP:0002605) | 4.20948161 |
| 8 | Hepatocellular necrosis (HP:0001404) | 4.19692509 |
| 9 | Mitochondrial inheritance (HP:0001427) | 4.17992084 |
| 10 | Acute encephalopathy (HP:0006846) | 4.16395710 |
| 11 | Reticulocytopenia (HP:0001896) | 4.16375254 |
| 12 | Macrocytic anemia (HP:0001972) | 3.96153457 |
| 13 | Increased CSF lactate (HP:0002490) | 3.90438047 |
| 14 | Progressive macrocephaly (HP:0004481) | 3.55190511 |
| 15 | Increased serum lactate (HP:0002151) | 3.43250801 |
| 16 | Lactic acidosis (HP:0003128) | 3.35723145 |
| 17 | Cerebral edema (HP:0002181) | 3.35580358 |
| 18 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 3.25200293 |
| 19 | Cerebral hypomyelination (HP:0006808) | 3.24918307 |
| 20 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.24884090 |
| 21 | Pallor (HP:0000980) | 3.23942710 |
| 22 | Increased hepatocellular lipid droplets (HP:0006565) | 3.18445492 |
| 23 | Lipid accumulation in hepatocytes (HP:0006561) | 3.18297974 |
| 24 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 3.17940045 |
| 25 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.12541306 |
| 26 | Oral leukoplakia (HP:0002745) | 3.11401818 |
| 27 | Increased intramyocellular lipid droplets (HP:0012240) | 3.10216947 |
| 28 | Hyperglycinemia (HP:0002154) | 3.01985680 |
| 29 | Increased IgM level (HP:0003496) | 2.97848863 |
| 30 | Aplastic anemia (HP:0001915) | 2.96718472 |
| 31 | Increased muscle lipid content (HP:0009058) | 2.95003929 |
| 32 | Progressive muscle weakness (HP:0003323) | 2.94484312 |
| 33 | Autoimmune thrombocytopenia (HP:0001973) | 2.92432868 |
| 34 | Lethargy (HP:0001254) | 2.92046525 |
| 35 | Birth length less than 3rd percentile (HP:0003561) | 2.87529878 |
| 36 | Respiratory failure (HP:0002878) | 2.82607534 |
| 37 | Multiple enchondromatosis (HP:0005701) | 2.78031937 |
| 38 | 3-Methylglutaconic aciduria (HP:0003535) | 2.76744470 |
| 39 | CNS demyelination (HP:0007305) | 2.72736814 |
| 40 | Hyperglycinuria (HP:0003108) | 2.70960931 |
| 41 | Exercise intolerance (HP:0003546) | 2.68230524 |
| 42 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.67195033 |
| 43 | Emotional lability (HP:0000712) | 2.64928070 |
| 44 | Rough bone trabeculation (HP:0100670) | 2.64407611 |
| 45 | Hypoglycemic coma (HP:0001325) | 2.61981115 |
| 46 | Renal Fanconi syndrome (HP:0001994) | 2.59032545 |
| 47 | Generalized aminoaciduria (HP:0002909) | 2.58594847 |
| 48 | Carpal bone hypoplasia (HP:0001498) | 2.54413397 |
| 49 | Abnormality of midbrain morphology (HP:0002418) | 2.52898429 |
| 50 | Molar tooth sign on MRI (HP:0002419) | 2.52898429 |
| 51 | Dicarboxylic aciduria (HP:0003215) | 2.46844022 |
| 52 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.46844022 |
| 53 | Dyschromatopsia (HP:0007641) | 2.45023064 |
| 54 | Delusions (HP:0000746) | 2.44982455 |
| 55 | Autoimmune hemolytic anemia (HP:0001890) | 2.41678632 |
| 56 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.41675981 |
| 57 | Breast hypoplasia (HP:0003187) | 2.40776224 |
| 58 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.38373711 |
| 59 | Methylmalonic acidemia (HP:0002912) | 2.34532936 |
| 60 | Microvesicular hepatic steatosis (HP:0001414) | 2.34376957 |
| 61 | Pancreatic cysts (HP:0001737) | 2.34218845 |
| 62 | Colon cancer (HP:0003003) | 2.34127430 |
| 63 | Abnormality of glycine metabolism (HP:0010895) | 2.33933602 |
| 64 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.33933602 |
| 65 | Microretrognathia (HP:0000308) | 2.31203105 |
| 66 | Abnormality of the ileum (HP:0001549) | 2.28825605 |
| 67 | Nausea (HP:0002018) | 2.28549029 |
| 68 | Exertional dyspnea (HP:0002875) | 2.28129618 |
| 69 | Meckel diverticulum (HP:0002245) | 2.25878167 |
| 70 | Pancreatic fibrosis (HP:0100732) | 2.21328762 |
| 71 | X-linked dominant inheritance (HP:0001423) | 2.19574848 |
| 72 | Type I transferrin isoform profile (HP:0003642) | 2.18994806 |
| 73 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.18244000 |
| 74 | Trismus (HP:0000211) | 2.17953627 |
| 75 | Abnormality of serum amino acid levels (HP:0003112) | 2.16997160 |
| 76 | Ragged-red muscle fibers (HP:0003200) | 2.16195873 |
| 77 | Gout (HP:0001997) | 2.16158925 |
| 78 | Hyperammonemia (HP:0001987) | 2.14890740 |
| 79 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.12473037 |
| 80 | Pancytopenia (HP:0001876) | 2.08319697 |
| 81 | Glycosuria (HP:0003076) | 2.07565841 |
| 82 | Abnormality of urine glucose concentration (HP:0011016) | 2.07565841 |
| 83 | Megaloblastic anemia (HP:0001889) | 2.05833506 |
| 84 | CNS hypomyelination (HP:0003429) | 2.05757205 |
| 85 | Hyperphosphaturia (HP:0003109) | 2.05064231 |
| 86 | Abnormality of reticulocytes (HP:0004312) | 2.03139952 |
| 87 | Secondary amenorrhea (HP:0000869) | 2.02931771 |
| 88 | Abnormal biliary tract physiology (HP:0012439) | 2.02177881 |
| 89 | Bile duct proliferation (HP:0001408) | 2.02177881 |
| 90 | Leukodystrophy (HP:0002415) | 1.99853644 |
| 91 | Abnormality of chromosome stability (HP:0003220) | 1.99344173 |
| 92 | Degeneration of anterior horn cells (HP:0002398) | 1.99264725 |
| 93 | Abnormality of the anterior horn cell (HP:0006802) | 1.99264725 |
| 94 | Medial flaring of the eyebrow (HP:0010747) | 1.98218090 |
| 95 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.97734634 |
| 96 | Abnormality of alanine metabolism (HP:0010916) | 1.97734634 |
| 97 | Hyperalaninemia (HP:0003348) | 1.97734634 |
| 98 | Abnormality of the preputium (HP:0100587) | 1.97723405 |
| 99 | Abnormality of renal resorption (HP:0011038) | 1.97418529 |
| 100 | Premature ovarian failure (HP:0008209) | 1.96606057 |
| 101 | Respiratory difficulties (HP:0002880) | 1.96449384 |
| 102 | Methylmalonic aciduria (HP:0012120) | 1.95634049 |
| 103 | 11 pairs of ribs (HP:0000878) | 1.95503161 |
| 104 | Neutropenia (HP:0001875) | 1.95419951 |
| 105 | IgM deficiency (HP:0002850) | 1.95256136 |
| 106 | Unsteady gait (HP:0002317) | 1.95053693 |
| 107 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.94836316 |
| 108 | Absent thumb (HP:0009777) | 1.94406714 |
| 109 | Increased serum pyruvate (HP:0003542) | 1.93685717 |
| 110 | Abnormality of glycolysis (HP:0004366) | 1.93685717 |
| 111 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 1.91829910 |
| 112 | Gliosis (HP:0002171) | 1.91610555 |
| 113 | Abnormal trabecular bone morphology (HP:0100671) | 1.91099995 |
| 114 | Hypobetalipoproteinemia (HP:0003563) | 1.89403688 |
| 115 | Dysautonomia (HP:0002459) | 1.88771382 |
| 116 | Abnormality of magnesium homeostasis (HP:0004921) | 1.88665620 |
| 117 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.87632385 |
| 118 | Vomiting (HP:0002013) | 1.87371963 |
| 119 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.85801285 |
| 120 | Sparse eyelashes (HP:0000653) | 1.83646213 |
| 121 | Testicular atrophy (HP:0000029) | 1.83620023 |
| 122 | Progressive microcephaly (HP:0000253) | 1.81002137 |
| 123 | Optic disc pallor (HP:0000543) | 1.80855939 |
| 124 | Congenital, generalized hypertrichosis (HP:0004540) | 1.80713077 |
| 125 | Proximal tubulopathy (HP:0000114) | 1.79940255 |
| 126 | Abnormality of T cell physiology (HP:0011840) | 1.79604065 |
| 127 | True hermaphroditism (HP:0010459) | 1.78190013 |
| 128 | Blindness (HP:0000618) | 1.78098661 |
| 129 | Nephronophthisis (HP:0000090) | 1.75332926 |
| 130 | Death in infancy (HP:0001522) | 1.74798881 |
| 131 | Eosinophilia (HP:0001880) | 1.74697346 |
| 132 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.74676471 |
| 133 | Abnormal hemoglobin (HP:0011902) | 1.74548051 |
| 134 | Chromsome breakage (HP:0040012) | 1.74135660 |
| 135 | Duodenal stenosis (HP:0100867) | 1.72077319 |
| 136 | Small intestinal stenosis (HP:0012848) | 1.72077319 |
| 137 | Abnormality of the labia minora (HP:0012880) | 1.69949327 |
| 138 | Abnormal protein glycosylation (HP:0012346) | 1.69536182 |
| 139 | Abnormal glycosylation (HP:0012345) | 1.69536182 |
| 140 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.69536182 |
| 141 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.69536182 |
| 142 | Abolished electroretinogram (ERG) (HP:0000550) | 1.66691748 |
| 143 | Sloping forehead (HP:0000340) | 1.66502180 |
| 144 | Type 2 muscle fiber atrophy (HP:0003554) | 1.65367837 |
| 145 | Clubbing of toes (HP:0100760) | 1.62134207 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.80598338 |
| 2 | NME2 | 4.72567152 |
| 3 | VRK2 | 3.82236708 |
| 4 | STK16 | 3.70158410 |
| 5 | EIF2AK1 | 3.51010113 |
| 6 | WEE1 | 3.46552328 |
| 7 | BCKDK | 3.33496854 |
| 8 | TESK2 | 2.92848339 |
| 9 | TLK1 | 2.71473774 |
| 10 | PIK3CA | 2.63674410 |
| 11 | ARAF | 2.63578280 |
| 12 | NME1 | 2.39361425 |
| 13 | VRK1 | 2.15768565 |
| 14 | KDR | 2.09234525 |
| 15 | PIM2 | 1.96496015 |
| 16 | MAP4K2 | 1.94242339 |
| 17 | PLK4 | 1.84748488 |
| 18 | SRPK1 | 1.78973703 |
| 19 | DYRK3 | 1.78443413 |
| 20 | BRAF | 1.78377733 |
| 21 | TSSK6 | 1.75367695 |
| 22 | MAP3K11 | 1.70108074 |
| 23 | NUAK1 | 1.69924334 |
| 24 | OXSR1 | 1.69183305 |
| 25 | EIF2AK3 | 1.57797542 |
| 26 | BMPR1B | 1.52140518 |
| 27 | PBK | 1.50503563 |
| 28 | SCYL2 | 1.46427189 |
| 29 | CDC7 | 1.44136396 |
| 30 | AURKA | 1.42516448 |
| 31 | NEK1 | 1.38538650 |
| 32 | MKNK2 | 1.36330753 |
| 33 | BMPR2 | 1.35836575 |
| 34 | PLK1 | 1.33863167 |
| 35 | MAP2K2 | 1.30136355 |
| 36 | MAPKAPK3 | 1.29574669 |
| 37 | TAF1 | 1.28688629 |
| 38 | NEK2 | 1.28310985 |
| 39 | BRSK2 | 1.27883829 |
| 40 | ACVR1B | 1.26997787 |
| 41 | MAP4K1 | 1.22534138 |
| 42 | RPS6KB2 | 1.19866831 |
| 43 | BRSK1 | 1.15999967 |
| 44 | TTK | 1.15550691 |
| 45 | WNK4 | 1.10687212 |
| 46 | CDK19 | 1.08695564 |
| 47 | FLT3 | 1.06949969 |
| 48 | AURKB | 1.06426912 |
| 49 | TRIM28 | 1.05798637 |
| 50 | GRK1 | 1.04890447 |
| 51 | PRKCG | 1.04806648 |
| 52 | MKNK1 | 1.03173569 |
| 53 | FRK | 1.03055260 |
| 54 | PASK | 1.02424213 |
| 55 | MAP3K12 | 1.02159243 |
| 56 | TESK1 | 0.96550710 |
| 57 | ZAP70 | 0.96449458 |
| 58 | CAMKK2 | 0.93585286 |
| 59 | EIF2AK2 | 0.93514348 |
| 60 | PDK2 | 0.92336754 |
| 61 | IRAK3 | 0.92303714 |
| 62 | CSNK1G1 | 0.92100056 |
| 63 | EPHA2 | 0.91504884 |
| 64 | CCNB1 | 0.87167911 |
| 65 | ZAK | 0.84484157 |
| 66 | PLK3 | 0.82555431 |
| 67 | RAF1 | 0.82009243 |
| 68 | CSNK1G2 | 0.81909746 |
| 69 | MAP2K3 | 0.80979626 |
| 70 | MAP3K3 | 0.79667306 |
| 71 | STK39 | 0.79579922 |
| 72 | MAP3K8 | 0.79103956 |
| 73 | CSNK2A2 | 0.78676674 |
| 74 | RPS6KA4 | 0.77844173 |
| 75 | GRK6 | 0.77695927 |
| 76 | PINK1 | 0.75195685 |
| 77 | MAP2K6 | 0.73312042 |
| 78 | NLK | 0.73127290 |
| 79 | CDK7 | 0.73006522 |
| 80 | MUSK | 0.72957496 |
| 81 | KIT | 0.72570433 |
| 82 | DAPK1 | 0.72451460 |
| 83 | LRRK2 | 0.72268894 |
| 84 | CSNK2A1 | 0.69653880 |
| 85 | CSNK1A1L | 0.69406455 |
| 86 | ATR | 0.69184983 |
| 87 | PRKG2 | 0.66356174 |
| 88 | LIMK1 | 0.66340426 |
| 89 | GRK7 | 0.64293650 |
| 90 | INSRR | 0.64277798 |
| 91 | MAP3K4 | 0.64147696 |
| 92 | GRK5 | 0.60791020 |
| 93 | ABL2 | 0.60290315 |
| 94 | PRKCI | 0.59290018 |
| 95 | TXK | 0.57969612 |
| 96 | PAK1 | 0.55678870 |
| 97 | ADRBK2 | 0.55071194 |
| 98 | MST4 | 0.54796966 |
| 99 | PIK3CG | 0.53011065 |
| 100 | WNK3 | 0.52678336 |
| 101 | DAPK3 | 0.51442856 |
| 102 | ATM | 0.50982384 |
| 103 | CDK8 | 0.49560361 |
| 104 | STK10 | 0.47136065 |
| 105 | MAP2K7 | 0.46885296 |
| 106 | AKT3 | 0.43796310 |
| 107 | RPS6KA5 | 0.43746720 |
| 108 | CHEK2 | 0.42972893 |
| 109 | MAPKAPK5 | 0.42509130 |
| 110 | ERN1 | 0.41462286 |
| 111 | DYRK2 | 0.40986998 |
| 112 | ADRBK1 | 0.39541317 |
| 113 | KSR2 | 0.38375300 |
| 114 | ILK | 0.38373578 |
| 115 | TEC | 0.37692125 |
| 116 | SYK | 0.37631865 |
| 117 | MAPK13 | 0.37452467 |
| 118 | ERBB3 | 0.37412860 |
| 119 | CDK4 | 0.36609170 |
| 120 | IKBKB | 0.36304300 |
| 121 | PRKCE | 0.35077012 |
| 122 | BLK | 0.33441341 |
| 123 | CSNK1G3 | 0.32636617 |
| 124 | CHEK1 | 0.32552341 |
| 125 | PIM1 | 0.32513207 |
| 126 | MARK3 | 0.30324041 |
| 127 | MAP2K1 | 0.29190545 |
| 128 | MAP3K9 | 0.28955341 |
| 129 | STK4 | 0.28556400 |
| 130 | SIK3 | 0.28009031 |
| 131 | CSNK1A1 | 0.26629660 |
| 132 | PAK4 | 0.26153898 |
| 133 | BTK | 0.26049227 |
| 134 | MYLK | 0.25561940 |
| 135 | CDK1 | 0.25477543 |
| 136 | CAMK2G | 0.25403194 |
| 137 | TAOK3 | 0.24976989 |
| 138 | TNIK | 0.24964250 |
| 139 | STK3 | 0.24948411 |
| 140 | CLK1 | 0.24628934 |
| 141 | CDK2 | 0.23841785 |
| 142 | FGFR4 | 0.23263681 |
| 143 | MAPK11 | 0.22376861 |
| 144 | TGFBR1 | 0.21511990 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 5.34158027 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.20490479 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 3.70407643 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 3.45827070 |
| 5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.11869725 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 2.99244476 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 2.89384751 |
| 8 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.69935584 |
| 9 | * Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.62491119 |
| 10 | Protein export_Homo sapiens_hsa03060 | 2.26672872 |
| 11 | Spliceosome_Homo sapiens_hsa03040 | 2.26399598 |
| 12 | Folate biosynthesis_Homo sapiens_hsa00790 | 2.19569453 |
| 13 | Huntingtons disease_Homo sapiens_hsa05016 | 2.17874783 |
| 14 | Homologous recombination_Homo sapiens_hsa03440 | 1.94652899 |
| 15 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.94564795 |
| 16 | * RNA transport_Homo sapiens_hsa03013 | 1.85836842 |
| 17 | Base excision repair_Homo sapiens_hsa03410 | 1.84941857 |
| 18 | Alzheimers disease_Homo sapiens_hsa05010 | 1.79509482 |
| 19 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.77988304 |
| 20 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.76259972 |
| 21 | Sulfur relay system_Homo sapiens_hsa04122 | 1.73203612 |
| 22 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.72909997 |
| 23 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.72851406 |
| 24 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.69328029 |
| 25 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.58779222 |
| 26 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.55701095 |
| 27 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.51424478 |
| 28 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.48668171 |
| 29 | Purine metabolism_Homo sapiens_hsa00230 | 1.40090812 |
| 30 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.38427452 |
| 31 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.35134382 |
| 32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.21469846 |
| 33 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.20595313 |
| 34 | RNA degradation_Homo sapiens_hsa03018 | 1.16987661 |
| 35 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.16177147 |
| 36 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.15542574 |
| 37 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.14565104 |
| 38 | Carbon metabolism_Homo sapiens_hsa01200 | 1.14291497 |
| 39 | Allograft rejection_Homo sapiens_hsa05330 | 1.11646371 |
| 40 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.11642142 |
| 41 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.10923773 |
| 42 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.09217220 |
| 43 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.09127238 |
| 44 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.08781054 |
| 45 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.04781126 |
| 46 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.04656218 |
| 47 | Basal transcription factors_Homo sapiens_hsa03022 | 1.02784908 |
| 48 | Cell cycle_Homo sapiens_hsa04110 | 1.01144508 |
| 49 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.98459726 |
| 50 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.95096645 |
| 51 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.91917730 |
| 52 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.91887418 |
| 53 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.88054274 |
| 54 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.86669711 |
| 55 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.85867410 |
| 56 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.85092762 |
| 57 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.84743200 |
| 58 | Metabolic pathways_Homo sapiens_hsa01100 | 0.84191970 |
| 59 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.82051700 |
| 60 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.79695247 |
| 61 | Asthma_Homo sapiens_hsa05310 | 0.77856106 |
| 62 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.76076539 |
| 63 | Peroxisome_Homo sapiens_hsa04146 | 0.75232359 |
| 64 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.73515029 |
| 65 | Phototransduction_Homo sapiens_hsa04744 | 0.73118379 |
| 66 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.66598894 |
| 67 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.63983393 |
| 68 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.62890937 |
| 69 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.62692379 |
| 70 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.61849142 |
| 71 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.60711712 |
| 72 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.59459410 |
| 73 | Galactose metabolism_Homo sapiens_hsa00052 | 0.58193917 |
| 74 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.57760229 |
| 75 | Thyroid cancer_Homo sapiens_hsa05216 | 0.55739214 |
| 76 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.52690365 |
| 77 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.51527192 |
| 78 | Retinol metabolism_Homo sapiens_hsa00830 | 0.47600987 |
| 79 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.47134679 |
| 80 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.43751931 |
| 81 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.43300511 |
| 82 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.43134602 |
| 83 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.41823515 |
| 84 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.41214250 |
| 85 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.41022045 |
| 86 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.40162724 |
| 87 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.40103170 |
| 88 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.39982773 |
| 89 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.39925267 |
| 90 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.39413399 |
| 91 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.37669857 |
| 92 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.35494965 |
| 93 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.34398179 |
| 94 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.33604532 |
| 95 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.32622810 |
| 96 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.32226254 |
| 97 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.31731588 |
| 98 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.31649960 |
| 99 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.31564616 |
| 100 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.31026104 |
| 101 | Olfactory transduction_Homo sapiens_hsa04740 | 0.28346578 |
| 102 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.28345248 |
| 103 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.28342215 |
| 104 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.27844413 |
| 105 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.27081337 |
| 106 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.26868777 |
| 107 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.26625249 |
| 108 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.23469194 |
| 109 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.23306648 |
| 110 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.23058648 |
| 111 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.23045597 |
| 112 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.22380365 |
| 113 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.21035212 |
| 114 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.21013818 |
| 115 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.20107445 |
| 116 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.19019387 |
| 117 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.15964291 |
| 118 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.14938004 |
| 119 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.14332542 |
| 120 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.14180229 |
| 121 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.13664731 |
| 122 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.13608604 |

