

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.47108784 |
| 2 | proteasome assembly (GO:0043248) | 5.37597781 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.26788874 |
| 4 | ATP synthesis coupled proton transport (GO:0015986) | 5.26788874 |
| 5 | DNA deamination (GO:0045006) | 5.10158110 |
| 6 | ribosomal small subunit assembly (GO:0000028) | 5.04689208 |
| 7 | ribosomal small subunit biogenesis (GO:0042274) | 4.74228629 |
| 8 | chaperone-mediated protein transport (GO:0072321) | 4.67653111 |
| 9 | viral transcription (GO:0019083) | 4.62539095 |
| 10 | translational termination (GO:0006415) | 4.56870134 |
| 11 | termination of RNA polymerase III transcription (GO:0006386) | 4.56507843 |
| 12 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.56507843 |
| 13 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.54107502 |
| 14 | maturation of SSU-rRNA (GO:0030490) | 4.42469788 |
| 15 | protein neddylation (GO:0045116) | 4.35651903 |
| 16 | cullin deneddylation (GO:0010388) | 4.22287760 |
| 17 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.20080816 |
| 18 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.20019949 |
| 19 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.15983480 |
| 20 | 7-methylguanosine mRNA capping (GO:0006370) | 4.15546737 |
| 21 | negative regulation of ligase activity (GO:0051352) | 4.15516798 |
| 22 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.15516798 |
| 23 | cotranslational protein targeting to membrane (GO:0006613) | 4.14198019 |
| 24 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.14049305 |
| 25 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.12669554 |
| 26 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.10595651 |
| 27 | 7-methylguanosine RNA capping (GO:0009452) | 4.06728057 |
| 28 | RNA capping (GO:0036260) | 4.06728057 |
| 29 | protein targeting to ER (GO:0045047) | 4.06356668 |
| 30 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.06101549 |
| 31 | NADH dehydrogenase complex assembly (GO:0010257) | 4.06101549 |
| 32 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.06101549 |
| 33 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.05723918 |
| 34 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.04048603 |
| 35 | protein deneddylation (GO:0000338) | 4.02198534 |
| 36 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.97747648 |
| 37 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.97747648 |
| 38 | translational elongation (GO:0006414) | 3.95943273 |
| 39 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.95270972 |
| 40 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.95270972 |
| 41 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.95270972 |
| 42 | protein localization to endoplasmic reticulum (GO:0070972) | 3.91333337 |
| 43 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.88705522 |
| 44 | protein complex biogenesis (GO:0070271) | 3.87689776 |
| 45 | ribosomal large subunit biogenesis (GO:0042273) | 3.86200189 |
| 46 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.84013757 |
| 47 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.84013757 |
| 48 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.83250507 |
| 49 | translation (GO:0006412) | 3.82980868 |
| 50 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.81739200 |
| 51 | cellular protein complex disassembly (GO:0043624) | 3.79459640 |
| 52 | translational initiation (GO:0006413) | 3.78307569 |
| 53 | respiratory electron transport chain (GO:0022904) | 3.77959963 |
| 54 | DNA damage response, detection of DNA damage (GO:0042769) | 3.74386963 |
| 55 | transcription from mitochondrial promoter (GO:0006390) | 3.68824662 |
| 56 | electron transport chain (GO:0022900) | 3.68734320 |
| 57 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.65954609 |
| 58 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.65878789 |
| 59 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.63582881 |
| 60 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.62163011 |
| 61 | viral life cycle (GO:0019058) | 3.60484533 |
| 62 | chromatin remodeling at centromere (GO:0031055) | 3.57837727 |
| 63 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.56757523 |
| 64 | pseudouridine synthesis (GO:0001522) | 3.55625847 |
| 65 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.55562488 |
| 66 | protein targeting to mitochondrion (GO:0006626) | 3.54964552 |
| 67 | regulation of mitochondrial translation (GO:0070129) | 3.54829030 |
| 68 | cellular component biogenesis (GO:0044085) | 3.51423475 |
| 69 | formation of translation preinitiation complex (GO:0001731) | 3.50057345 |
| 70 | establishment of protein localization to mitochondrion (GO:0072655) | 3.49602370 |
| 71 | spliceosomal snRNP assembly (GO:0000387) | 3.49181800 |
| 72 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.47920306 |
| 73 | positive regulation of ligase activity (GO:0051351) | 3.47873520 |
| 74 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.44377717 |
| 75 | peptidyl-histidine modification (GO:0018202) | 3.43844451 |
| 76 | rRNA processing (GO:0006364) | 3.42885228 |
| 77 | protein maturation by protein folding (GO:0022417) | 3.42881166 |
| 78 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.41403994 |
| 79 | rRNA modification (GO:0000154) | 3.40372037 |
| 80 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.38570673 |
| 81 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.36185072 |
| 82 | oxidative phosphorylation (GO:0006119) | 3.34117499 |
| 83 | GTP biosynthetic process (GO:0006183) | 3.32389273 |
| 84 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.31960124 |
| 85 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.31526584 |
| 86 | kinetochore assembly (GO:0051382) | 3.29488722 |
| 87 | rRNA metabolic process (GO:0016072) | 3.28799804 |
| 88 | UTP biosynthetic process (GO:0006228) | 3.28008590 |
| 89 | respiratory chain complex IV assembly (GO:0008535) | 3.27521068 |
| 90 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.27382012 |
| 91 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.27382012 |
| 92 | ribosome assembly (GO:0042255) | 3.26049168 |
| 93 | DNA replication checkpoint (GO:0000076) | 3.25768621 |
| 94 | establishment of integrated proviral latency (GO:0075713) | 3.25662453 |
| 95 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.25599875 |
| 96 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.25115709 |
| 97 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.24374608 |
| 98 | protein complex disassembly (GO:0043241) | 3.24090763 |
| 99 | CENP-A containing nucleosome assembly (GO:0034080) | 3.23882440 |
| 100 | DNA strand elongation (GO:0022616) | 3.23618483 |
| 101 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.22348904 |
| 102 | protein localization to mitochondrion (GO:0070585) | 3.22297984 |
| 103 | ribosome biogenesis (GO:0042254) | 3.21969245 |
| 104 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.18514218 |
| 105 | mitochondrial RNA metabolic process (GO:0000959) | 3.17661603 |
| 106 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.16696794 |
| 107 | telomere maintenance via recombination (GO:0000722) | 3.16175372 |
| 108 | transcription elongation from RNA polymerase II promoter (GO:0006368) | 3.15937715 |
| 109 | DNA unwinding involved in DNA replication (GO:0006268) | 3.15523255 |
| 110 | CTP metabolic process (GO:0046036) | 3.15047914 |
| 111 | CTP biosynthetic process (GO:0006241) | 3.15047914 |
| 112 | purine nucleobase biosynthetic process (GO:0009113) | 3.14496976 |
| 113 | nucleobase biosynthetic process (GO:0046112) | 3.14464321 |
| 114 | macromolecular complex disassembly (GO:0032984) | 3.13977968 |
| 115 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.13801516 |
| 116 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 3.13637285 |
| 117 | regulation of ligase activity (GO:0051340) | 3.12094342 |
| 118 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.12006494 |
| 119 | mitotic metaphase plate congression (GO:0007080) | 3.10410557 |
| 120 | establishment of viral latency (GO:0019043) | 3.09443472 |
| 121 | DNA replication initiation (GO:0006270) | 3.08366876 |
| 122 | positive regulation of cell cycle arrest (GO:0071158) | 3.06984984 |
| 123 | spliceosomal complex assembly (GO:0000245) | 3.06868916 |
| 124 | kinetochore organization (GO:0051383) | 3.06420321 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.83442115 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.57837848 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.28165441 |
| 4 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.28026978 |
| 5 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.19435811 |
| 6 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.18455894 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.85419937 |
| 8 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.82687613 |
| 9 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.64459936 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.56145382 |
| 11 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.53194204 |
| 12 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.39116969 |
| 13 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.25024327 |
| 14 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.12202748 |
| 15 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.06222686 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.94485279 |
| 17 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.85790992 |
| 18 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.79279199 |
| 19 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.78992815 |
| 20 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.77990866 |
| 21 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.74230058 |
| 22 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.66618774 |
| 23 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.63618485 |
| 24 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.58050469 |
| 25 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.55526802 |
| 26 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.48739971 |
| 27 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.39174118 |
| 28 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.30175426 |
| 29 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.29166170 |
| 30 | * GABP_19822575_ChIP-Seq_HepG2_Human | 2.27342063 |
| 31 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.24289796 |
| 32 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.18297320 |
| 33 | * PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.17559690 |
| 34 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.16384204 |
| 35 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.16168904 |
| 36 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.03564208 |
| 37 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.94321057 |
| 38 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.91841872 |
| 39 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.88267497 |
| 40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.80437395 |
| 41 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.74448407 |
| 42 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.69752657 |
| 43 | * POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.68538732 |
| 44 | * PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.66267495 |
| 45 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.64080863 |
| 46 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.63059928 |
| 47 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.62147472 |
| 48 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.60718166 |
| 49 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.54433424 |
| 50 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.53009785 |
| 51 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.51718766 |
| 52 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.45291822 |
| 53 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.40806717 |
| 54 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.32198453 |
| 55 | * SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.32128309 |
| 56 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.31182547 |
| 57 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.29645315 |
| 58 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28925237 |
| 59 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.27991350 |
| 60 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.26863460 |
| 61 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.20437629 |
| 62 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.20158624 |
| 63 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.20015676 |
| 64 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.17331412 |
| 65 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.16404978 |
| 66 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.15570169 |
| 67 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.12632585 |
| 68 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.12538864 |
| 69 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.10207642 |
| 70 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.07904910 |
| 71 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.06207179 |
| 72 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.05896285 |
| 73 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.05722746 |
| 74 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.04186950 |
| 75 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.03563291 |
| 76 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.03063602 |
| 77 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.01400715 |
| 78 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.00832665 |
| 79 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.99812197 |
| 80 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.99778482 |
| 81 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.97745128 |
| 82 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.97484173 |
| 83 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.97433220 |
| 84 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.96274818 |
| 85 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.95498312 |
| 86 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.95329705 |
| 87 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.94892627 |
| 88 | * ZNF263_19887448_ChIP-Seq_K562_Human | 0.93534007 |
| 89 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.92631634 |
| 90 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.92408517 |
| 91 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.91551177 |
| 92 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.87938238 |
| 93 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.86122055 |
| 94 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.85651242 |
| 95 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.85520002 |
| 96 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.84915084 |
| 97 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.82358671 |
| 98 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.82259208 |
| 99 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.81452086 |
| 100 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.81299675 |
| 101 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.78380220 |
| 102 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.77984160 |
| 103 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.75682840 |
| 104 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.75244637 |
| 105 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.74411093 |
| 106 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.70344819 |
| 107 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.69226087 |
| 108 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.68843016 |
| 109 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.68093139 |
| 110 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.64635656 |
| 111 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.62028577 |
| 112 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.61957120 |
| 113 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.61919266 |
| 114 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.61315889 |
| 115 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.60877966 |
| 116 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.60261827 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.13720706 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 3.62844622 |
| 3 | MP0001529_abnormal_vocalization | 3.47421442 |
| 4 | MP0003077_abnormal_cell_cycle | 2.97124975 |
| 5 | MP0010094_abnormal_chromosome_stability | 2.96394591 |
| 6 | MP0003111_abnormal_nucleus_morphology | 2.89214590 |
| 7 | MP0009379_abnormal_foot_pigmentation | 2.82929491 |
| 8 | MP0008058_abnormal_DNA_repair | 2.79929972 |
| 9 | MP0008057_abnormal_DNA_replication | 2.79928379 |
| 10 | MP0010030_abnormal_orbit_morphology | 2.60381103 |
| 11 | MP0008932_abnormal_embryonic_tissue | 2.38137881 |
| 12 | MP0003718_maternal_effect | 2.32124412 |
| 13 | MP0003786_premature_aging | 2.05751848 |
| 14 | MP0006292_abnormal_olfactory_placode | 2.03488788 |
| 15 | MP0001905_abnormal_dopamine_level | 1.99753854 |
| 16 | MP0002638_abnormal_pupillary_reflex | 1.99119852 |
| 17 | MP0003880_abnormal_central_pattern | 1.92586870 |
| 18 | MP0006036_abnormal_mitochondrial_physio | 1.86684566 |
| 19 | MP0006035_abnormal_mitochondrial_morpho | 1.85207168 |
| 20 | MP0003941_abnormal_skin_development | 1.84597566 |
| 21 | MP0003136_yellow_coat_color | 1.77989986 |
| 22 | MP0001986_abnormal_taste_sensitivity | 1.74329862 |
| 23 | MP0008007_abnormal_cellular_replicative | 1.73482181 |
| 24 | MP0000372_irregular_coat_pigmentation | 1.72917335 |
| 25 | MP0009333_abnormal_splenocyte_physiolog | 1.72685471 |
| 26 | MP0002163_abnormal_gland_morphology | 1.69261765 |
| 27 | MP0003186_abnormal_redox_activity | 1.68307732 |
| 28 | MP0006276_abnormal_autonomic_nervous | 1.63948331 |
| 29 | MP0000049_abnormal_middle_ear | 1.61219035 |
| 30 | MP0005075_abnormal_melanosome_morpholog | 1.60715957 |
| 31 | MP0000490_abnormal_crypts_of | 1.56676384 |
| 32 | MP0001293_anophthalmia | 1.51785406 |
| 33 | MP0000015_abnormal_ear_pigmentation | 1.47349058 |
| 34 | MP0002132_abnormal_respiratory_system | 1.41193805 |
| 35 | MP0005671_abnormal_response_to | 1.39324724 |
| 36 | MP0003123_paternal_imprinting | 1.37945493 |
| 37 | MP0002736_abnormal_nociception_after | 1.36763223 |
| 38 | MP0002735_abnormal_chemical_nociception | 1.35603978 |
| 39 | MP0009785_altered_susceptibility_to | 1.32042027 |
| 40 | MP0001835_abnormal_antigen_presentation | 1.28132216 |
| 41 | MP0003806_abnormal_nucleotide_metabolis | 1.26373268 |
| 42 | MP0001346_abnormal_lacrimal_gland | 1.24671490 |
| 43 | MP0002277_abnormal_respiratory_mucosa | 1.22767958 |
| 44 | MP0002396_abnormal_hematopoietic_system | 1.21489917 |
| 45 | MP0000358_abnormal_cell_content/ | 1.18285306 |
| 46 | MP0005380_embryogenesis_phenotype | 1.16689868 |
| 47 | MP0001672_abnormal_embryogenesis/_devel | 1.16689868 |
| 48 | MP0001968_abnormal_touch/_nociception | 1.16335863 |
| 49 | MP0000313_abnormal_cell_death | 1.15416538 |
| 50 | MP0009672_abnormal_birth_weight | 1.14851061 |
| 51 | MP0001853_heart_inflammation | 1.14835243 |
| 52 | MP0008877_abnormal_DNA_methylation | 1.14754954 |
| 53 | MP0001727_abnormal_embryo_implantation | 1.14394639 |
| 54 | MP0002148_abnormal_hypersensitivity_rea | 1.13976556 |
| 55 | MP0002102_abnormal_ear_morphology | 1.13032119 |
| 56 | MP0003937_abnormal_limbs/digits/tail_de | 1.12797203 |
| 57 | MP0002085_abnormal_embryonic_tissue | 1.12758090 |
| 58 | MP0008260_abnormal_autophagy | 1.12529781 |
| 59 | MP0001730_embryonic_growth_arrest | 1.12440467 |
| 60 | MP0000678_abnormal_parathyroid_gland | 1.10412113 |
| 61 | MP0005501_abnormal_skin_physiology | 1.10138869 |
| 62 | MP0003315_abnormal_perineum_morphology | 1.09108897 |
| 63 | MP0000350_abnormal_cell_proliferation | 1.06200020 |
| 64 | MP0003656_abnormal_erythrocyte_physiolo | 1.03590182 |
| 65 | MP0004142_abnormal_muscle_tone | 1.02154117 |
| 66 | MP0002751_abnormal_autonomic_nervous | 1.01909208 |
| 67 | MP0001764_abnormal_homeostasis | 1.01329500 |
| 68 | MP0008789_abnormal_olfactory_epithelium | 1.01155457 |
| 69 | MP0002938_white_spotting | 1.00534096 |
| 70 | MP0002233_abnormal_nose_morphology | 1.00390781 |
| 71 | MP0002095_abnormal_skin_pigmentation | 1.00191752 |
| 72 | MP0002398_abnormal_bone_marrow | 0.99406396 |
| 73 | MP0002234_abnormal_pharynx_morphology | 0.99084599 |
| 74 | MP0000537_abnormal_urethra_morphology | 0.95157146 |
| 75 | MP0000750_abnormal_muscle_regeneration | 0.95084905 |
| 76 | MP0002160_abnormal_reproductive_system | 0.94581915 |
| 77 | MP0004233_abnormal_muscle_weight | 0.94467961 |
| 78 | MP0002249_abnormal_larynx_morphology | 0.93533206 |
| 79 | MP0001188_hyperpigmentation | 0.93287864 |
| 80 | MP0003763_abnormal_thymus_physiology | 0.92541820 |
| 81 | MP0002697_abnormal_eye_size | 0.92073820 |
| 82 | MP0005000_abnormal_immune_tolerance | 0.91249471 |
| 83 | MP0002210_abnormal_sex_determination | 0.90677674 |
| 84 | MP0003567_abnormal_fetal_cardiomyocyte | 0.90309898 |
| 85 | MP0005379_endocrine/exocrine_gland_phen | 0.89610377 |
| 86 | MP0003984_embryonic_growth_retardation | 0.88857378 |
| 87 | MP0009697_abnormal_copulation | 0.88033858 |
| 88 | MP0002019_abnormal_tumor_incidence | 0.87875070 |
| 89 | MP0000689_abnormal_spleen_morphology | 0.87094326 |
| 90 | MP0002420_abnormal_adaptive_immunity | 0.86536573 |
| 91 | MP0004147_increased_porphyrin_level | 0.86535800 |
| 92 | MP0008995_early_reproductive_senescence | 0.86535235 |
| 93 | MP0002111_abnormal_tail_morphology | 0.85629014 |
| 94 | MP0001819_abnormal_immune_cell | 0.85599671 |
| 95 | MP0000653_abnormal_sex_gland | 0.85497218 |
| 96 | MP0003121_genomic_imprinting | 0.84595511 |
| 97 | MP0003866_abnormal_defecation | 0.84591712 |
| 98 | MP0002088_abnormal_embryonic_growth/wei | 0.84504405 |
| 99 | MP0001545_abnormal_hematopoietic_system | 0.83946794 |
| 100 | MP0005397_hematopoietic_system_phenotyp | 0.83946794 |
| 101 | MP0002084_abnormal_developmental_patter | 0.83915699 |
| 102 | MP0002722_abnormal_immune_system | 0.83632204 |
| 103 | MP0010386_abnormal_urinary_bladder | 0.83378249 |
| 104 | MP0002429_abnormal_blood_cell | 0.83236244 |
| 105 | MP0001970_abnormal_pain_threshold | 0.82789274 |
| 106 | MP0005025_abnormal_response_to | 0.80418733 |
| 107 | MP0002734_abnormal_mechanical_nocicepti | 0.80020352 |
| 108 | MP0002723_abnormal_immune_serum | 0.79934940 |
| 109 | MP0003119_abnormal_digestive_system | 0.78857113 |
| 110 | MP0005670_abnormal_white_adipose | 0.77838451 |
| 111 | MP0005408_hypopigmentation | 0.77541813 |
| 112 | MP0000716_abnormal_immune_system | 0.76769628 |
| 113 | MP0002452_abnormal_antigen_presenting | 0.76114292 |
| 114 | MP0005174_abnormal_tail_pigmentation | 0.75722035 |
| 115 | MP0002177_abnormal_outer_ear | 0.75342379 |
| 116 | MP0003942_abnormal_urinary_system | 0.74480078 |
| 117 | MP0001145_abnormal_male_reproductive | 0.74274020 |
| 118 | MP0003879_abnormal_hair_cell | 0.74260887 |
| 119 | MP0001800_abnormal_humoral_immune | 0.73895151 |
| 120 | MP0005394_taste/olfaction_phenotype | 0.73772802 |
| 121 | MP0005499_abnormal_olfactory_system | 0.73772802 |
| 122 | MP0001697_abnormal_embryo_size | 0.72954081 |
| 123 | MP0006082_CNS_inflammation | 0.71795523 |
| 124 | MP0005646_abnormal_pituitary_gland | 0.71511781 |
| 125 | MP0010307_abnormal_tumor_latency | 0.71372383 |
| 126 | MP0005266_abnormal_metabolism | 0.71342378 |
| 127 | MP0003436_decreased_susceptibility_to | 0.70559893 |
| 128 | MP0005389_reproductive_system_phenotype | 0.70552642 |
| 129 | MP0000703_abnormal_thymus_morphology | 0.70314179 |
| 130 | MP0005409_darkened_coat_color | 0.70221058 |
| 131 | MP0003938_abnormal_ear_development | 0.70059222 |
| 132 | MP0000749_muscle_degeneration | 0.69790179 |
| 133 | MP0002080_prenatal_lethality | 0.68570888 |
| 134 | MP0004133_heterotaxia | 0.68452729 |
| 135 | MP0001286_abnormal_eye_development | 0.67650781 |
| 136 | MP0005623_abnormal_meninges_morphology | 0.67345914 |
| 137 | MP0001929_abnormal_gametogenesis | 0.66733953 |
| 138 | MP0009053_abnormal_anal_canal | 0.65437296 |
| 139 | MP0001919_abnormal_reproductive_system | 0.65011660 |
| 140 | MP0002092_abnormal_eye_morphology | 0.63214352 |
| 141 | MP0009250_abnormal_appendicular_skeleto | 0.62791719 |
| 142 | MP0002796_impaired_skin_barrier | 0.62503974 |
| 143 | MP0003861_abnormal_nervous_system | 0.62086045 |
| 144 | MP0002161_abnormal_fertility/fecundity | 0.61716683 |
| 145 | MP0004197_abnormal_fetal_growth/weight/ | 0.61426529 |
| 146 | MP0002090_abnormal_vision | 0.60708273 |
| 147 | MP0005332_abnormal_amino_acid | 0.60340552 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.68537585 |
| 2 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.19259454 |
| 3 | Mitochondrial inheritance (HP:0001427) | 5.15508446 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.04603855 |
| 5 | Abnormal number of erythroid precursors (HP:0012131) | 4.82764454 |
| 6 | Hepatocellular necrosis (HP:0001404) | 4.70529221 |
| 7 | Progressive macrocephaly (HP:0004481) | 4.55209052 |
| 8 | Increased CSF lactate (HP:0002490) | 4.51140138 |
| 9 | Acute encephalopathy (HP:0006846) | 4.37888084 |
| 10 | Reticulocytopenia (HP:0001896) | 4.06806331 |
| 11 | Increased hepatocellular lipid droplets (HP:0006565) | 4.01914120 |
| 12 | 3-Methylglutaconic aciduria (HP:0003535) | 3.91451630 |
| 13 | Birth length less than 3rd percentile (HP:0003561) | 3.86109417 |
| 14 | Hepatic necrosis (HP:0002605) | 3.85722932 |
| 15 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.74428628 |
| 16 | Lipid accumulation in hepatocytes (HP:0006561) | 3.49622413 |
| 17 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.49072915 |
| 18 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.49072915 |
| 19 | Increased serum lactate (HP:0002151) | 3.45038374 |
| 20 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.44748761 |
| 21 | Cerebral hypomyelination (HP:0006808) | 3.34547117 |
| 22 | Macrocytic anemia (HP:0001972) | 3.29047837 |
| 23 | Renal Fanconi syndrome (HP:0001994) | 3.27546918 |
| 24 | Exertional dyspnea (HP:0002875) | 3.27492818 |
| 25 | Aplastic anemia (HP:0001915) | 3.15508702 |
| 26 | Abnormality of glycolysis (HP:0004366) | 3.11710432 |
| 27 | Increased serum pyruvate (HP:0003542) | 3.11710432 |
| 28 | Respiratory failure (HP:0002878) | 3.07912169 |
| 29 | Exercise intolerance (HP:0003546) | 3.07044799 |
| 30 | Pallor (HP:0000980) | 3.06013606 |
| 31 | Lactic acidosis (HP:0003128) | 2.98705347 |
| 32 | Type I transferrin isoform profile (HP:0003642) | 2.91258683 |
| 33 | Breast hypoplasia (HP:0003187) | 2.82364784 |
| 34 | Optic disc pallor (HP:0000543) | 2.78934027 |
| 35 | Increased intramyocellular lipid droplets (HP:0012240) | 2.73434619 |
| 36 | Respiratory difficulties (HP:0002880) | 2.72839828 |
| 37 | Multiple enchondromatosis (HP:0005701) | 2.71514928 |
| 38 | Rough bone trabeculation (HP:0100670) | 2.69299735 |
| 39 | Leukodystrophy (HP:0002415) | 2.66824383 |
| 40 | Oral leukoplakia (HP:0002745) | 2.62606213 |
| 41 | Progressive muscle weakness (HP:0003323) | 2.61073329 |
| 42 | Cerebral edema (HP:0002181) | 2.60358913 |
| 43 | Testicular atrophy (HP:0000029) | 2.58171557 |
| 44 | Carpal bone hypoplasia (HP:0001498) | 2.51110465 |
| 45 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.44610336 |
| 46 | Abnormal glycosylation (HP:0012345) | 2.41755965 |
| 47 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.41755965 |
| 48 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.41755965 |
| 49 | Abnormal protein glycosylation (HP:0012346) | 2.41755965 |
| 50 | Patellar aplasia (HP:0006443) | 2.36479798 |
| 51 | Emotional lability (HP:0000712) | 2.36449392 |
| 52 | Facial cleft (HP:0002006) | 2.35142674 |
| 53 | CNS demyelination (HP:0007305) | 2.35086603 |
| 54 | Irregular epiphyses (HP:0010582) | 2.34997457 |
| 55 | Ragged-red muscle fibers (HP:0003200) | 2.33180399 |
| 56 | Microvesicular hepatic steatosis (HP:0001414) | 2.28761639 |
| 57 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.28711070 |
| 58 | Abnormal hair whorl (HP:0010721) | 2.26905912 |
| 59 | Reduced antithrombin III activity (HP:0001976) | 2.24755358 |
| 60 | Hyperalaninemia (HP:0003348) | 2.22890936 |
| 61 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.22890936 |
| 62 | Abnormality of alanine metabolism (HP:0010916) | 2.22890936 |
| 63 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.21955325 |
| 64 | Abnormality of the preputium (HP:0100587) | 2.20323557 |
| 65 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.18781288 |
| 66 | Increased muscle lipid content (HP:0009058) | 2.17532797 |
| 67 | Abnormal trabecular bone morphology (HP:0100671) | 2.17509104 |
| 68 | Chromsome breakage (HP:0040012) | 2.17249210 |
| 69 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.13294474 |
| 70 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.12742774 |
| 71 | Colon cancer (HP:0003003) | 2.11668127 |
| 72 | Lethargy (HP:0001254) | 2.07944641 |
| 73 | Methylmalonic aciduria (HP:0012120) | 2.06392875 |
| 74 | CNS hypomyelination (HP:0003429) | 2.04402556 |
| 75 | Bone marrow hypocellularity (HP:0005528) | 2.03596383 |
| 76 | Pancytopenia (HP:0001876) | 2.03111743 |
| 77 | Poor suck (HP:0002033) | 2.02941717 |
| 78 | Abnormal number of incisors (HP:0011064) | 1.99826276 |
| 79 | Secondary amenorrhea (HP:0000869) | 1.99663908 |
| 80 | Hyperglycinemia (HP:0002154) | 1.99071613 |
| 81 | Delusions (HP:0000746) | 1.98973032 |
| 82 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.98585959 |
| 83 | IgM deficiency (HP:0002850) | 1.97694407 |
| 84 | Sparse eyelashes (HP:0000653) | 1.97585209 |
| 85 | Abnormality of the ileum (HP:0001549) | 1.95795925 |
| 86 | Meckel diverticulum (HP:0002245) | 1.95281432 |
| 87 | Microretrognathia (HP:0000308) | 1.93968994 |
| 88 | Generalized aminoaciduria (HP:0002909) | 1.93371077 |
| 89 | 11 pairs of ribs (HP:0000878) | 1.93324936 |
| 90 | Absent thumb (HP:0009777) | 1.92775358 |
| 91 | Progressive microcephaly (HP:0000253) | 1.92020157 |
| 92 | Trismus (HP:0000211) | 1.89124857 |
| 93 | Gout (HP:0001997) | 1.88036119 |
| 94 | Premature graying of hair (HP:0002216) | 1.88008460 |
| 95 | Abnormality of the anterior horn cell (HP:0006802) | 1.86722263 |
| 96 | Degeneration of anterior horn cells (HP:0002398) | 1.86722263 |
| 97 | Unsteady gait (HP:0002317) | 1.86711682 |
| 98 | Abnormality of renal resorption (HP:0011038) | 1.85760331 |
| 99 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.85657553 |
| 100 | Hypoplastic pelvis (HP:0008839) | 1.85139150 |
| 101 | Type 2 muscle fiber atrophy (HP:0003554) | 1.85088372 |
| 102 | Absent epiphyses (HP:0010577) | 1.83613585 |
| 103 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.83613585 |
| 104 | Poor head control (HP:0002421) | 1.80911518 |
| 105 | Triphalangeal thumb (HP:0001199) | 1.80390011 |
| 106 | Postnatal microcephaly (HP:0005484) | 1.78941075 |
| 107 | Pancreatic fibrosis (HP:0100732) | 1.77317352 |
| 108 | Abnormal lung lobation (HP:0002101) | 1.76914770 |
| 109 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.76761143 |
| 110 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.76761143 |
| 111 | Single umbilical artery (HP:0001195) | 1.76761143 |
| 112 | Abnormality of placental membranes (HP:0011409) | 1.76450109 |
| 113 | Amniotic constriction ring (HP:0009775) | 1.76450109 |
| 114 | Selective tooth agenesis (HP:0001592) | 1.75150307 |
| 115 | Parakeratosis (HP:0001036) | 1.73889787 |
| 116 | Abnormality of the umbilical cord (HP:0010881) | 1.73000150 |
| 117 | Cleft eyelid (HP:0000625) | 1.71440781 |
| 118 | Squamous cell carcinoma (HP:0002860) | 1.71432607 |
| 119 | X-linked dominant inheritance (HP:0001423) | 1.71009246 |
| 120 | Pancreatic cysts (HP:0001737) | 1.70776377 |
| 121 | Stenosis of the external auditory canal (HP:0000402) | 1.70706738 |
| 122 | Cellular immunodeficiency (HP:0005374) | 1.70681293 |
| 123 | Opisthotonus (HP:0002179) | 1.70540758 |
| 124 | True hermaphroditism (HP:0010459) | 1.70460624 |
| 125 | Septate vagina (HP:0001153) | 1.69808266 |
| 126 | Glossoptosis (HP:0000162) | 1.68789085 |
| 127 | Abnormality of the labia minora (HP:0012880) | 1.68530591 |
| 128 | Ependymoma (HP:0002888) | 1.67281023 |
| 129 | Horseshoe kidney (HP:0000085) | 1.66986317 |
| 130 | Abnormality of chromosome stability (HP:0003220) | 1.66308221 |
| 131 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.65917726 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.95461145 |
| 2 | NME2 | 3.90354631 |
| 3 | VRK2 | 3.85824469 |
| 4 | STK16 | 3.43358434 |
| 5 | WEE1 | 3.24430279 |
| 6 | EIF2AK1 | 3.09234666 |
| 7 | MAP3K12 | 2.84549483 |
| 8 | VRK1 | 2.69842806 |
| 9 | NME1 | 2.53795428 |
| 10 | PIM2 | 2.28677508 |
| 11 | BCKDK | 2.07054818 |
| 12 | TSSK6 | 1.99825695 |
| 13 | EIF2AK3 | 1.97975895 |
| 14 | ARAF | 1.96253556 |
| 15 | SRPK1 | 1.95251976 |
| 16 | PLK4 | 1.91787665 |
| 17 | CCNB1 | 1.91447691 |
| 18 | PDK2 | 1.75299763 |
| 19 | CDC7 | 1.70450505 |
| 20 | TRIM28 | 1.66813142 |
| 21 | PBK | 1.66549175 |
| 22 | DYRK2 | 1.60463365 |
| 23 | TLK1 | 1.60184211 |
| 24 | BRSK2 | 1.59374019 |
| 25 | BRAF | 1.57034050 |
| 26 | TESK2 | 1.53891518 |
| 27 | CASK | 1.43688734 |
| 28 | CDK19 | 1.37495700 |
| 29 | BRSK1 | 1.32974205 |
| 30 | PLK3 | 1.24836122 |
| 31 | SIK3 | 1.23223809 |
| 32 | PLK1 | 1.23027492 |
| 33 | IRAK4 | 1.13603304 |
| 34 | AURKA | 1.11382812 |
| 35 | LIMK1 | 1.11162701 |
| 36 | MAP2K7 | 1.08322367 |
| 37 | MKNK1 | 1.06769964 |
| 38 | ADRBK2 | 1.06529248 |
| 39 | ACVR1B | 1.05522961 |
| 40 | STK4 | 1.05334509 |
| 41 | DYRK3 | 1.02053990 |
| 42 | TTK | 0.99714856 |
| 43 | SMG1 | 0.98051133 |
| 44 | MAP3K11 | 0.95386501 |
| 45 | GRK5 | 0.89706438 |
| 46 | MYLK | 0.88938558 |
| 47 | CSNK1G1 | 0.88459800 |
| 48 | IRAK3 | 0.88385129 |
| 49 | AURKB | 0.87940909 |
| 50 | CSNK1A1L | 0.87187993 |
| 51 | BMPR1B | 0.85328421 |
| 52 | EIF2AK2 | 0.84668195 |
| 53 | CHEK1 | 0.84284885 |
| 54 | MST4 | 0.83400904 |
| 55 | PNCK | 0.82734558 |
| 56 | DAPK1 | 0.80861403 |
| 57 | TEC | 0.80664885 |
| 58 | ZAK | 0.80579295 |
| 59 | CDK8 | 0.80308538 |
| 60 | CSNK1G2 | 0.76439624 |
| 61 | PLK2 | 0.75993327 |
| 62 | MKNK2 | 0.75246015 |
| 63 | ABL2 | 0.73956372 |
| 64 | MUSK | 0.73734545 |
| 65 | MAP3K8 | 0.72478747 |
| 66 | ATR | 0.71594422 |
| 67 | TXK | 0.71105902 |
| 68 | CHEK2 | 0.70249782 |
| 69 | MARK1 | 0.70133608 |
| 70 | MAPK13 | 0.69333164 |
| 71 | CSNK2A1 | 0.69274568 |
| 72 | LRRK2 | 0.68592051 |
| 73 | TESK1 | 0.67488404 |
| 74 | PAK1 | 0.67445381 |
| 75 | ILK | 0.66869269 |
| 76 | NUAK1 | 0.63882579 |
| 77 | CSNK2A2 | 0.63719039 |
| 78 | CLK1 | 0.63168858 |
| 79 | KDR | 0.61976168 |
| 80 | CDK7 | 0.61746370 |
| 81 | AKT2 | 0.61335930 |
| 82 | BMPR2 | 0.60441259 |
| 83 | MAP4K2 | 0.60285910 |
| 84 | RPS6KB2 | 0.59575864 |
| 85 | RPS6KA5 | 0.58758041 |
| 86 | PIM1 | 0.58605732 |
| 87 | GRK7 | 0.58082110 |
| 88 | YES1 | 0.56110939 |
| 89 | TAF1 | 0.55562558 |
| 90 | SCYL2 | 0.54029413 |
| 91 | UHMK1 | 0.53494806 |
| 92 | BCR | 0.52973872 |
| 93 | DAPK3 | 0.51927430 |
| 94 | BLK | 0.51774290 |
| 95 | MAP3K6 | 0.51654361 |
| 96 | ATM | 0.50547826 |
| 97 | NEK2 | 0.49783851 |
| 98 | PRKCI | 0.49146701 |
| 99 | CDK1 | 0.47710944 |
| 100 | CSNK1G3 | 0.46904008 |
| 101 | RPS6KA4 | 0.46867451 |
| 102 | TAOK2 | 0.46825094 |
| 103 | CDK2 | 0.46800926 |
| 104 | EPHA2 | 0.46550409 |
| 105 | MINK1 | 0.46275569 |
| 106 | NEK1 | 0.45634394 |
| 107 | SYK | 0.45520239 |
| 108 | MAP4K1 | 0.45189289 |
| 109 | STK24 | 0.45025953 |
| 110 | CSNK1E | 0.44632025 |
| 111 | CDK18 | 0.42660805 |
| 112 | WNK3 | 0.42411503 |
| 113 | LYN | 0.42066456 |
| 114 | GRK6 | 0.41542978 |
| 115 | MAPK4 | 0.40676730 |
| 116 | CDK11A | 0.40138556 |
| 117 | CDK14 | 0.39185655 |
| 118 | CDK15 | 0.35643771 |
| 119 | PAK4 | 0.34113975 |
| 120 | EPHA4 | 0.33225595 |
| 121 | CAMK2G | 0.33181038 |
| 122 | TNIK | 0.32549059 |
| 123 | IKBKB | 0.32401388 |
| 124 | FES | 0.31969648 |
| 125 | RIPK4 | 0.30775415 |
| 126 | CDK4 | 0.29795214 |
| 127 | RAF1 | 0.27133048 |
| 128 | PRKCG | 0.25964791 |
| 129 | PKN1 | 0.25925587 |
| 130 | ERBB4 | 0.25747055 |
| 131 | ALK | 0.24789248 |
| 132 | WNK4 | 0.24695776 |
| 133 | CSNK1A1 | 0.23532440 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.98193294 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.78032394 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 4.15153860 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.88169011 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.42650309 |
| 6 | DNA replication_Homo sapiens_hsa03030 | 3.23912321 |
| 7 | Mismatch repair_Homo sapiens_hsa03430 | 2.83530926 |
| 8 | * Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.68128056 |
| 9 | Huntingtons disease_Homo sapiens_hsa05016 | 2.67242316 |
| 10 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.61772462 |
| 11 | Spliceosome_Homo sapiens_hsa03040 | 2.56857098 |
| 12 | Alzheimers disease_Homo sapiens_hsa05010 | 2.37020937 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 2.28790202 |
| 14 | Protein export_Homo sapiens_hsa03060 | 2.24783193 |
| 15 | Base excision repair_Homo sapiens_hsa03410 | 2.17396950 |
| 16 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.14783237 |
| 17 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.02038924 |
| 18 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.92639836 |
| 19 | * RNA transport_Homo sapiens_hsa03013 | 1.90807357 |
| 20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.87250397 |
| 21 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.70233853 |
| 22 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.57303159 |
| 23 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.57033315 |
| 24 | Purine metabolism_Homo sapiens_hsa00230 | 1.48144333 |
| 25 | RNA degradation_Homo sapiens_hsa03018 | 1.44084351 |
| 26 | Cell cycle_Homo sapiens_hsa04110 | 1.43443954 |
| 27 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.42522552 |
| 28 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.41567902 |
| 29 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.37983188 |
| 30 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.33097560 |
| 31 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.24721489 |
| 32 | Carbon metabolism_Homo sapiens_hsa01200 | 1.14381957 |
| 33 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.13502736 |
| 34 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.12781478 |
| 35 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.12692468 |
| 36 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.97388653 |
| 37 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.96441946 |
| 38 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.93953485 |
| 39 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.92818752 |
| 40 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.92725550 |
| 41 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.92701400 |
| 42 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.80870423 |
| 43 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.79710358 |
| 44 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.78048937 |
| 45 | Allograft rejection_Homo sapiens_hsa05330 | 0.77711762 |
| 46 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.76522324 |
| 47 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.76516104 |
| 48 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.74027580 |
| 49 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.73858340 |
| 50 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.71714248 |
| 51 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.71291656 |
| 52 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.69746686 |
| 53 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.69466626 |
| 54 | Asthma_Homo sapiens_hsa05310 | 0.67040996 |
| 55 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.66558669 |
| 56 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.66192590 |
| 57 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.65650764 |
| 58 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.62837678 |
| 59 | Sulfur relay system_Homo sapiens_hsa04122 | 0.62091597 |
| 60 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.60487242 |
| 61 | Metabolic pathways_Homo sapiens_hsa01100 | 0.59034161 |
| 62 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.58356421 |
| 63 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.56684325 |
| 64 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.56364102 |
| 65 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.56314285 |
| 66 | Phagosome_Homo sapiens_hsa04145 | 0.54608297 |
| 67 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.54353387 |
| 68 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.53448471 |
| 69 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.50390841 |
| 70 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.48571030 |
| 71 | Legionellosis_Homo sapiens_hsa05134 | 0.48429263 |
| 72 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.48177023 |
| 73 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.47791560 |
| 74 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.46992998 |
| 75 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.46212398 |
| 76 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.46102770 |
| 77 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.44584615 |
| 78 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.42538732 |
| 79 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.41644265 |
| 80 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.41256860 |
| 81 | Shigellosis_Homo sapiens_hsa05131 | 0.41092866 |
| 82 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.40570375 |
| 83 | Peroxisome_Homo sapiens_hsa04146 | 0.40471581 |
| 84 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.39399054 |
| 85 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.39067075 |
| 86 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.38533091 |
| 87 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.36713410 |
| 88 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.32203314 |
| 89 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.32039085 |
| 90 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.31180060 |
| 91 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.30887643 |
| 92 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.30233017 |
| 93 | Phototransduction_Homo sapiens_hsa04744 | 0.29624267 |
| 94 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.29143074 |
| 95 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.28923545 |
| 96 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.26663009 |
| 97 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.26626269 |
| 98 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.26432547 |
| 99 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.26013062 |
| 100 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.25117973 |
| 101 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.24066619 |
| 102 | Alcoholism_Homo sapiens_hsa05034 | 0.23126157 |
| 103 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.22596423 |
| 104 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.21667360 |
| 105 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.20989765 |
| 106 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.19960953 |
| 107 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.18649780 |
| 108 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.18582673 |
| 109 | Salmonella infection_Homo sapiens_hsa05132 | 0.18099635 |
| 110 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.17895415 |
| 111 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.16233592 |
| 112 | Pertussis_Homo sapiens_hsa05133 | 0.15726882 |
| 113 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.15612174 |
| 114 | Measles_Homo sapiens_hsa05162 | 0.15190563 |
| 115 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.14483189 |
| 116 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.14086175 |
| 117 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.13363221 |
| 118 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.12577225 |
| 119 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.11934405 |
| 120 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.11384907 |
| 121 | Nicotine addiction_Homo sapiens_hsa05033 | 0.11324600 |
| 122 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.10392007 |
| 123 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.09145729 |
| 124 | Apoptosis_Homo sapiens_hsa04210 | 0.08721200 |
| 125 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.08570766 |
| 126 | Galactose metabolism_Homo sapiens_hsa00052 | 0.08290816 |
| 127 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.06843998 |
| 128 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.06839907 |
| 129 | Tuberculosis_Homo sapiens_hsa05152 | 0.06329231 |
| 130 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.05437306 |
| 131 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.04890273 |
| 132 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.01787306 |
| 133 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.01354499 |
| 134 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.01139634 |
| 135 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.00603917 |
| 136 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | -0.0091126 |
| 137 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | -0.0073102 |

