POPDC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the POP family of proteins containing three putative transmembrane domains. This gene is expressed in cardiac and skeletal muscle and may play an important role in these tissues during development. Alternatively spliced transcript variants have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)9.55462564
2muscle filament sliding (GO:0030049)9.55462564
3actin-mediated cell contraction (GO:0070252)7.99096255
4sarcoplasmic reticulum calcium ion transport (GO:0070296)7.39475550
5sarcomere organization (GO:0045214)7.25502307
6plasma membrane repair (GO:0001778)7.23719827
7regulation of skeletal muscle contraction (GO:0014819)7.02560751
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.85848970
9skeletal muscle contraction (GO:0003009)6.81115403
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.50738648
11response to muscle activity (GO:0014850)6.09787010
12actin filament-based movement (GO:0030048)6.00555984
13myofibril assembly (GO:0030239)5.86910519
14regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.82794124
15negative regulation of potassium ion transmembrane transport (GO:1901380)5.80475268
16regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.78877964
17cardiac myofibril assembly (GO:0055003)5.73418824
18striated muscle contraction (GO:0006941)5.65933134
19skeletal muscle fiber development (GO:0048741)5.20104456
20muscle cell fate commitment (GO:0042693)5.10840370
21cardiac muscle contraction (GO:0060048)5.02203573
22regulation of cell communication by electrical coupling (GO:0010649)4.96197003
23actomyosin structure organization (GO:0031032)4.94753093
24cardiac muscle cell development (GO:0055013)4.93757519
25regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.91442256
26response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.80696704
27creatine metabolic process (GO:0006600)4.61570300
28regulation of relaxation of muscle (GO:1901077)4.59243498
29cardiac cell development (GO:0055006)4.58093537
30muscle contraction (GO:0006936)4.57779338
31tricarboxylic acid cycle (GO:0006099)4.54087266
32myotube cell development (GO:0014904)4.49560068
33skeletal muscle tissue regeneration (GO:0043403)4.41765844
34carnitine shuttle (GO:0006853)4.40228537
35regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.39505229
36regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.39132221
37muscle fiber development (GO:0048747)4.39044512
38regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.38820898
39glycogen catabolic process (GO:0005980)4.32670478
40striated muscle cell development (GO:0055002)4.27728464
41negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.24744678
42regulation of acyl-CoA biosynthetic process (GO:0050812)4.21006380
43regulation of striated muscle contraction (GO:0006942)4.19621897
44muscle tissue morphogenesis (GO:0060415)4.16938994
45muscle cell cellular homeostasis (GO:0046716)4.15120787
46cardiac muscle tissue morphogenesis (GO:0055008)4.13698441
47response to inactivity (GO:0014854)4.12308614
48ventricular cardiac muscle cell action potential (GO:0086005)4.11558486
49muscle system process (GO:0003012)4.10413085
50glucan biosynthetic process (GO:0009250)4.09569134
51glycogen biosynthetic process (GO:0005978)4.09569134
52regulation of cofactor metabolic process (GO:0051193)4.09181659
53regulation of coenzyme metabolic process (GO:0051196)4.09181659
54regulation of membrane repolarization (GO:0060306)4.04010731
55regulation of actin filament-based movement (GO:1903115)4.01719738
56skeletal muscle adaptation (GO:0043501)4.00915563
57positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.99449302
58regulation of the force of heart contraction (GO:0002026)3.99365434
59glucan catabolic process (GO:0009251)3.98764239
60positive regulation of myotube differentiation (GO:0010831)3.96566743
61NADH metabolic process (GO:0006734)3.93506212
62bundle of His cell to Purkinje myocyte communication (GO:0086069)3.80282283
63cardiac muscle hypertrophy (GO:0003300)3.77140385
64regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.73113613
65muscle cell development (GO:0055001)3.72045403
66cellular polysaccharide catabolic process (GO:0044247)3.71085294
67striated muscle hypertrophy (GO:0014897)3.68722038
68myoblast fusion (GO:0007520)3.67716990
69heart process (GO:0003015)3.64068061
70heart contraction (GO:0060047)3.64068061
71cell communication involved in cardiac conduction (GO:0086065)3.62186851
72fatty acid transmembrane transport (GO:1902001)3.57958750
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.53612283
74striated muscle adaptation (GO:0014888)3.52922699
75gluconeogenesis (GO:0006094)3.52900972
76cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.48767580
77regulation of sarcomere organization (GO:0060297)3.47643151
78negative regulation of calcium ion transmembrane transport (GO:1903170)3.46545087
79negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.46545087
80regulation of calcium ion transmembrane transporter activity (GO:1901019)3.45086774
81regulation of calcium ion transmembrane transport (GO:1903169)3.45086774
82heart trabecula formation (GO:0060347)3.44327614
83ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.42958188
84striated muscle atrophy (GO:0014891)3.35309297
85cytidine metabolic process (GO:0046087)3.34555578
86cytidine catabolic process (GO:0006216)3.34555578
87cytidine deamination (GO:0009972)3.34555578
88energy coupled proton transport, down electrochemical gradient (GO:0015985)3.33193424
89ATP synthesis coupled proton transport (GO:0015986)3.33193424
90regulation of potassium ion transmembrane transporter activity (GO:1901016)3.30784416
91polysaccharide catabolic process (GO:0000272)3.29172449
92syncytium formation by plasma membrane fusion (GO:0000768)3.25039774
93AMP metabolic process (GO:0046033)3.24645256
94regulation of sulfur metabolic process (GO:0042762)3.23471158
95syncytium formation (GO:0006949)3.23270398
96negative regulation of potassium ion transport (GO:0043267)3.23234118
97pyrimidine ribonucleoside catabolic process (GO:0046133)3.22999316
98regulation of cardioblast differentiation (GO:0051890)3.22457740
99muscle organ development (GO:0007517)3.21239675
100negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.20589532
101regulation of ATPase activity (GO:0043462)3.19131083
102regulation of ATP catabolic process (GO:1903289)3.19131083
103glycogen metabolic process (GO:0005977)3.18571874
104skeletal muscle tissue development (GO:0007519)3.18467903
105muscle hypertrophy (GO:0014896)3.15902315
106muscle structure development (GO:0061061)3.15288413
107hexose biosynthetic process (GO:0019319)3.14797736
108regulation of cardioblast proliferation (GO:0003264)3.14788578
109regulation of secondary heart field cardioblast proliferation (GO:0003266)3.14788578
110muscle organ morphogenesis (GO:0048644)3.13539985
111positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.13179167
112carnitine transmembrane transport (GO:1902603)3.10627939
113regulation of muscle contraction (GO:0006937)3.10395886
114cellular glucan metabolic process (GO:0006073)3.09736542
115glucan metabolic process (GO:0044042)3.09736542
116cell communication by electrical coupling (GO:0010644)3.08607553
117adult heart development (GO:0007512)3.07722389
118cardiac muscle cell action potential involved in contraction (GO:0086002)3.07544681
119positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07396449
120cardiac muscle cell action potential (GO:0086001)3.07286992
121regulation of heart rate (GO:0002027)3.04434145
122relaxation of muscle (GO:0090075)3.03045621
123negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.01255341
124regulation of skeletal muscle cell differentiation (GO:2001014)3.00764022
125striated muscle tissue development (GO:0014706)3.00676490
126regulation of muscle system process (GO:0090257)2.99898936
127response to activity (GO:0014823)2.95875266
128positive regulation of cation channel activity (GO:2001259)2.89055248
129myotube differentiation (GO:0014902)2.83991186
130fructose metabolic process (GO:0006000)2.83231215
131muscle tissue development (GO:0060537)2.75415472
132regulation of myoblast differentiation (GO:0045661)2.75262833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF263_19887448_ChIP-Seq_K562_Human4.76271498
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.07445631
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.72873744
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.57177371
5* EP300_21415370_ChIP-Seq_HL-1_Mouse3.47658227
6ESR1_20079471_ChIP-ChIP_T-47D_Human3.41632463
7MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.90984883
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.88624770
9TBX20_22080862_ChIP-Seq_HEART_Mouse2.79068453
10TBX20_22328084_ChIP-Seq_HEART_Mouse2.79068453
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.50091583
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.43108767
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.27170419
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.27030951
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21427388
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.18009602
17ZNF274_21170338_ChIP-Seq_K562_Hela1.96055912
18GATA4_21415370_ChIP-Seq_HL-1_Mouse1.84522768
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78175589
20EZH2_22144423_ChIP-Seq_EOC_Human1.76599484
21THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71314066
22ATF3_27146783_Chip-Seq_COLON_Human1.70412728
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70222962
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69091920
25CLOCK_20551151_ChIP-Seq_293T_Human1.64314189
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.63537262
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.63413574
28RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.63350500
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59930401
30BRD4_25478319_ChIP-Seq_HGPS_Human1.59490866
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58927839
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.58761193
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.58217557
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55680910
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.53732726
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51984350
37ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.49971172
38CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.49197200
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.46700647
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45470501
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40292242
42* CJUN_26792858_Chip-Seq_BT549_Human1.38162826
43ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.38149296
44RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37265481
45CTCF_27219007_Chip-Seq_Bcells_Human1.35540763
46NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35001912
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.34608811
48AR_21909140_ChIP-Seq_LNCAP_Human1.33613956
49RACK7_27058665_Chip-Seq_MCF-7_Human1.33585039
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29782175
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29249227
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28372780
53* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25956999
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25087017
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24582750
56TBX5_21415370_ChIP-Seq_HL-1_Mouse1.24149958
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21793577
58SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.21641623
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21443350
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20435631
61SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20435631
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20267545
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.17181685
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16890164
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16769387
66NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16479170
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16420900
68JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16294105
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.15497617
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15439190
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.15103579
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14657606
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14650460
74* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14013019
75PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13973791
76BP1_19119308_ChIP-ChIP_Hs578T_Human1.13433930
77* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12058461
78NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11178776
79* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10292331
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.08501839
81* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08429161
82* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08429161
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07698348
84* EZH2_27294783_Chip-Seq_NPCs_Mouse1.07615416
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07485567
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07241402
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07095542
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05567758
89FOXH1_21741376_ChIP-Seq_ESCs_Human1.05539028
90JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05266085
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04790546
92SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04722279
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03535576
94E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03446620
95EZH2_27304074_Chip-Seq_ESCs_Mouse1.01176892
96SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00968065
97* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00575257
98PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.99818465
99* CRX_20693478_ChIP-Seq_RETINA_Mouse0.99071949
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.98017365
101KDM2B_26808549_Chip-Seq_K562_Human0.96741502
102RUNX1_27514584_Chip-Seq_MCF-7_Human0.96731707
103SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95666386
104SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95516416
105* EZH2_27294783_Chip-Seq_ESCs_Mouse0.94191622
106PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93524432
107KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93302179
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91519156
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91319905
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89928521
111CTCF_21964334_Chip-Seq_Bcells_Human0.89776059
112TP63_22573176_ChIP-Seq_HFKS_Human0.89723882
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89586211
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88927517
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88927517
116BCAT_22108803_ChIP-Seq_LS180_Human0.88690698
117SA1_27219007_Chip-Seq_Bcells_Human0.88688688
118* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.88155131
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88115727
120* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88016732
121* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87251554
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86357727
123TP53_23651856_ChIP-Seq_MEFs_Mouse0.86349048
124STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85004115
125SOX2_21211035_ChIP-Seq_LN229_Gbm0.84793201
126NFI_21473784_ChIP-Seq_ESCs_Mouse0.83173436
127DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82953655
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82407943
129EOMES_21245162_ChIP-Seq_HESCs_Human0.81619242
130SUZ12_27294783_Chip-Seq_NPCs_Mouse0.81143174
131STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.80736353
132GBX2_23144817_ChIP-Seq_PC3_Human0.80532103
133RARB_27405468_Chip-Seq_BRAIN_Mouse0.80526976
134* UBF1/2_26484160_Chip-Seq_HMECs_Human0.80368180
135KDM2B_26808549_Chip-Seq_DND41_Human0.80223397
136CREB1_15753290_ChIP-ChIP_HEK293T_Human0.79861431
137TP53_22127205_ChIP-Seq_IMR90_Human0.79808771
138DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79491238
139ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77657598
140PHF8_20622853_ChIP-Seq_HELA_Human0.77578611
141CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.77284699
142FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.75386558
143* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.74930381
144* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.74642320
145PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74057788
146* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.74056735
147PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.73802200
148ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.73337919
149GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.73200320
150KLF4_19829295_ChIP-Seq_ESCs_Human0.72940756
151ERG_21242973_ChIP-ChIP_JURKAT_Human0.72772164
152JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72718398
153AHR_22903824_ChIP-Seq_MCF-7_Human0.72364740
154DCP1A_22483619_ChIP-Seq_HELA_Human0.71857902
155TFEB_21752829_ChIP-Seq_HELA_Human0.71328556

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy5.76379378
2MP0000749_muscle_degeneration5.67224701
3MP0004145_abnormal_muscle_electrophysio4.91805759
4MP0002837_dystrophic_cardiac_calcinosis4.66199051
5MP0003646_muscle_fatigue4.39280773
6MP0004084_abnormal_cardiac_muscle4.13633842
7MP0004036_abnormal_muscle_relaxation3.78625255
8MP0000750_abnormal_muscle_regeneration3.77940025
9MP0000747_muscle_weakness3.48259580
10MP0002106_abnormal_muscle_physiology3.48045763
11MP0004087_abnormal_muscle_fiber3.39161591
12MP0004215_abnormal_myocardial_fiber3.13009805
13MP0002269_muscular_atrophy3.12136134
14MP0005330_cardiomyopathy3.06574827
15MP0000759_abnormal_skeletal_muscle2.97212766
16MP0005369_muscle_phenotype2.91744370
17MP0005620_abnormal_muscle_contractility2.73149159
18MP0004233_abnormal_muscle_weight2.50799607
19MP0002972_abnormal_cardiac_muscle2.40762062
20MP0000372_irregular_coat_pigmentation2.30448533
21MP0000733_abnormal_muscle_development2.28759830
22MP0004270_analgesia2.21480952
23MP0009780_abnormal_chondrocyte_physiolo2.04511202
24MP0004130_abnormal_muscle_cell1.96507487
25MP0004484_altered_response_of1.94614967
26MP0003137_abnormal_impulse_conducting1.90793147
27MP0010630_abnormal_cardiac_muscle1.88150570
28MP0008775_abnormal_heart_ventricle1.86352988
29MP0003950_abnormal_plasma_membrane1.79175391
30MP0002108_abnormal_muscle_morphology1.72461489
31MP0001544_abnormal_cardiovascular_syste1.69927543
32MP0005385_cardiovascular_system_phenoty1.69927543
33MP0003221_abnormal_cardiomyocyte_apopto1.61809270
34MP0006138_congestive_heart_failure1.56359523
35MP0002735_abnormal_chemical_nociception1.46170742
36MP0004085_abnormal_heartbeat1.44808941
37MP0006036_abnormal_mitochondrial_physio1.42644697
38MP0005171_absent_coat_pigmentation1.40023927
39MP0002234_abnormal_pharynx_morphology1.35445248
40MP0002332_abnormal_exercise_endurance1.34359964
41MP0001661_extended_life_span1.31191384
42MP0003828_pulmonary_edema1.30145322
43MP0004510_myositis1.23732436
44MP0004858_abnormal_nervous_system1.13702927
45MP0002127_abnormal_cardiovascular_syste1.12278831
46MP0000013_abnormal_adipose_tissue1.11902847
47MP0001299_abnormal_eye_distance/1.03174860
48MP0002734_abnormal_mechanical_nocicepti1.01825928
49MP0003567_abnormal_fetal_cardiomyocyte0.97234720
50MP0003705_abnormal_hypodermis_morpholog0.89209607
51MP0006035_abnormal_mitochondrial_morpho0.88217529
52MP0010030_abnormal_orbit_morphology0.88012888
53MP0006276_abnormal_autonomic_nervous0.87676488
54MP0003566_abnormal_cell_adhesion0.84647092
55MP0000266_abnormal_heart_morphology0.79766718
56MP0005670_abnormal_white_adipose0.79728046
57MP0010368_abnormal_lymphatic_system0.78291792
58MP0004185_abnormal_adipocyte_glucose0.77025335
59MP0001440_abnormal_grooming_behavior0.70638950
60MP0005275_abnormal_skin_tensile0.70423652
61MP0005408_hypopigmentation0.69906736
62MP0005666_abnormal_adipose_tissue0.69664452
63MP0002184_abnormal_innervation0.68752543
64MP0003279_aneurysm0.68496788
65MP0005266_abnormal_metabolism0.67977828
66MP0003045_fibrosis0.67955724
67MP0002971_abnormal_brown_adipose0.66751324
68MP0005503_abnormal_tendon_morphology0.66389564
69MP0005623_abnormal_meninges_morphology0.65597091
70MP0003136_yellow_coat_color0.58810403
71MP0001968_abnormal_touch/_nociception0.58398943
72MP0005375_adipose_tissue_phenotype0.57494693
73MP0000767_abnormal_smooth_muscle0.57228532
74MP0008438_abnormal_cutaneous_collagen0.57186906
75MP0002733_abnormal_thermal_nociception0.57004535
76MP0009250_abnormal_appendicular_skeleto0.56536885
77MP0000762_abnormal_tongue_morphology0.55679744
78MP0001879_abnormal_lymphatic_vessel0.55671033
79MP0005165_increased_susceptibility_to0.54789061
80MP0001970_abnormal_pain_threshold0.53878597
81MP0004134_abnormal_chest_morphology0.53304781
82MP0003186_abnormal_redox_activity0.52230755
83MP0001542_abnormal_bone_strength0.51723927
84MP0000015_abnormal_ear_pigmentation0.50424209
85MP0000003_abnormal_adipose_tissue0.49612907
86MP0002128_abnormal_blood_circulation0.48809475
87MP0009697_abnormal_copulation0.46647515
88MP0003091_abnormal_cell_migration0.45723344
89MP0004147_increased_porphyrin_level0.45383747
90MP0003806_abnormal_nucleotide_metabolis0.44663350
91MP0000230_abnormal_systemic_arterial0.43694345
92MP0002177_abnormal_outer_ear0.43679255
93MP0000343_altered_response_to0.42917887
94MP0001986_abnormal_taste_sensitivity0.42796083
95MP0002736_abnormal_nociception_after0.41907043
96MP0003941_abnormal_skin_development0.41840369
97MP0003329_amyloid_beta_deposits0.41839611
98MP0004272_abnormal_basement_membrane0.41135501
99MP0005257_abnormal_intraocular_pressure0.40505629
100MP0002822_catalepsy0.40199348
101MP0002638_abnormal_pupillary_reflex0.40126460
102MP0002295_abnormal_pulmonary_circulatio0.39881263
103MP0010234_abnormal_vibrissa_follicle0.39778703
104MP0005197_abnormal_uvea_morphology0.39005685
105MP0005451_abnormal_body_composition0.38962991
106MP0002938_white_spotting0.38097047
107MP0002114_abnormal_axial_skeleton0.36661357
108MP0000534_abnormal_ureter_morphology0.36029407
109MP0002877_abnormal_melanocyte_morpholog0.36027755
110MP0005452_abnormal_adipose_tissue0.35814404
111MP0002896_abnormal_bone_mineralization0.35537022
112MP0008569_lethality_at_weaning0.33591240
113MP0003879_abnormal_hair_cell0.32922161
114MP0001958_emphysema0.32738139
115MP0005584_abnormal_enzyme/coenzyme_acti0.31039934
116MP0005187_abnormal_penis_morphology0.30910123
117MP0002925_abnormal_cardiovascular_devel0.29926466
118MP0004859_abnormal_synaptic_plasticity0.29909617
119MP0001348_abnormal_lacrimal_gland0.29737038
120MP0001943_abnormal_respiration0.29692032
121MP0001784_abnormal_fluid_regulation0.29581220
122MP0005332_abnormal_amino_acid0.29376723
123MP0009384_cardiac_valve_regurgitation0.29149743
124MP0000358_abnormal_cell_content/0.28952134
125MP0002909_abnormal_adrenal_gland0.28523123
126MP0001727_abnormal_embryo_implantation0.28152475
127MP0001730_embryonic_growth_arrest0.26892447
128MP0002067_abnormal_sensory_capabilities0.26690715

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.25125935
2Muscle fiber inclusion bodies (HP:0100299)7.24288787
3Nemaline bodies (HP:0003798)6.73997790
4Type 1 muscle fiber predominance (HP:0003803)5.84789151
5Exercise-induced myalgia (HP:0003738)5.42956996
6Distal arthrogryposis (HP:0005684)5.38224485
7Hyporeflexia of lower limbs (HP:0002600)5.24432969
8Muscle hypertrophy of the lower extremities (HP:0008968)5.18518906
9Calf muscle hypertrophy (HP:0008981)5.17659875
10Muscle fiber splitting (HP:0003555)5.12599442
11Exercise-induced muscle cramps (HP:0003710)5.05299896
12Fetal akinesia sequence (HP:0001989)4.80227294
13Popliteal pterygium (HP:0009756)4.74758900
14Abnormality of the calf musculature (HP:0001430)4.69439623
15Sudden death (HP:0001699)4.64604707
16EMG: myopathic abnormalities (HP:0003458)4.55293772
17Difficulty running (HP:0009046)4.40422591
18Myopathic facies (HP:0002058)4.18728251
19Difficulty climbing stairs (HP:0003551)4.08379371
20Abnormality of the neuromuscular junction (HP:0003398)4.07994047
21Fatigable weakness (HP:0003473)4.07994047
22Round ear (HP:0100830)3.99558347
23Increased connective tissue (HP:0009025)3.99361213
24Aplasia of the musculature (HP:0100854)3.93751254
25Malignant hyperthermia (HP:0002047)3.90856046
26Abnormality of placental membranes (HP:0011409)3.77844742
27Amniotic constriction ring (HP:0009775)3.77844742
28Myotonia (HP:0002486)3.69042354
29Ulnar deviation of the wrist (HP:0003049)3.69041998
30Type 2 muscle fiber atrophy (HP:0003554)3.65980360
31Myoglobinuria (HP:0002913)3.47487842
32Abnormality of skeletal muscle fiber size (HP:0012084)3.46865994
33Gowers sign (HP:0003391)3.40987910
34Ventricular tachycardia (HP:0004756)3.40193797
35Absent phalangeal crease (HP:0006109)3.39452814
36Muscle fiber atrophy (HP:0100295)3.38092847
37Weak cry (HP:0001612)3.30569858
38Increased variability in muscle fiber diameter (HP:0003557)3.27214035
39Neck muscle weakness (HP:0000467)3.24047053
40Calcaneovalgus deformity (HP:0001848)3.23926796
41Distal lower limb muscle weakness (HP:0009053)3.16797896
42Areflexia of lower limbs (HP:0002522)3.14827794
43Right ventricular cardiomyopathy (HP:0011663)3.12490368
44Subaortic stenosis (HP:0001682)3.11122440
45Abnormality of the left ventricular outflow tract (HP:0011103)3.11122440
46Deformed tarsal bones (HP:0008119)3.04581308
47Rhabdomyolysis (HP:0003201)2.98885715
48Muscle stiffness (HP:0003552)2.93086949
49Mildly elevated creatine phosphokinase (HP:0008180)2.92350000
50Generalized muscle weakness (HP:0003324)2.86787014
51Bulbar palsy (HP:0001283)2.84892393
52Atrial fibrillation (HP:0005110)2.80905784
53Hypoplastic heart (HP:0001961)2.78969359
54Lipoatrophy (HP:0100578)2.77756901
55EMG: neuropathic changes (HP:0003445)2.77564273
56Abnormal finger flexion creases (HP:0006143)2.73350344
57Akinesia (HP:0002304)2.69678531
58Primary atrial arrhythmia (HP:0001692)2.67762980
59Pterygium (HP:0001059)2.62762348
60Supraventricular tachycardia (HP:0004755)2.57116177
61Easy fatigability (HP:0003388)2.55722414
62Scapular winging (HP:0003691)2.51488540
63Supraventricular arrhythmia (HP:0005115)2.51435761
64Limb-girdle muscle atrophy (HP:0003797)2.50643976
65Distal lower limb amyotrophy (HP:0008944)2.47023403
66Aplasia/Hypoplasia involving the musculature (HP:0001460)2.43577751
67Thin ribs (HP:0000883)2.42494997
68Asymmetric septal hypertrophy (HP:0001670)2.41810010
69Spinal rigidity (HP:0003306)2.41072233
70Centrally nucleated skeletal muscle fibers (HP:0003687)2.35552434
71Dilated cardiomyopathy (HP:0001644)2.35533649
72Rimmed vacuoles (HP:0003805)2.35305813
73Palpitations (HP:0001962)2.32398567
74Bundle branch block (HP:0011710)2.32085701
75Syncope (HP:0001279)2.31827847
76Ventricular arrhythmia (HP:0004308)2.31739231
77Shoulder girdle muscle weakness (HP:0003547)2.31001499
78Abnormality of the hip-girdle musculature (HP:0001445)2.29312712
79Abnormality of the musculature of the pelvis (HP:0001469)2.29312712
80Respiratory insufficiency due to muscle weakness (HP:0002747)2.29245252
81Frequent falls (HP:0002359)2.21564472
82Pelvic girdle muscle weakness (HP:0003749)2.20825966
83Abnormal atrioventricular conduction (HP:0005150)2.20322995
84Atrioventricular block (HP:0001678)2.20268321
85Muscular dystrophy (HP:0003560)2.19097200
86Facial diplegia (HP:0001349)2.16742147
87Abnormality of the shoulder girdle musculature (HP:0001435)2.16569097
88Foot dorsiflexor weakness (HP:0009027)2.13911527
89Heart block (HP:0012722)2.12359112
90Abnormality of the foot musculature (HP:0001436)2.09982702
91Hip contracture (HP:0003273)2.09974509
92Cystic hygroma (HP:0000476)2.08953052
93Ventricular fibrillation (HP:0001663)2.03016794
94Exercise intolerance (HP:0003546)2.02439177
95Prolonged QT interval (HP:0001657)2.01190302
96Progressive muscle weakness (HP:0003323)1.93642890
97Limb-girdle muscle weakness (HP:0003325)1.92371313
98Pheochromocytoma (HP:0002666)1.92070298
99Lower limb amyotrophy (HP:0007210)1.90807047
100Slender build (HP:0001533)1.88792375
101Abnormality of the calcaneus (HP:0008364)1.88607892
102Proximal amyotrophy (HP:0007126)1.87021278
103Waddling gait (HP:0002515)1.80136842
104Reduced subcutaneous adipose tissue (HP:0003758)1.78879113
105Hyperkalemia (HP:0002153)1.70223278
106Ragged-red muscle fibers (HP:0003200)1.69833372
107Generalized amyotrophy (HP:0003700)1.63157236
108Increased intramyocellular lipid droplets (HP:0012240)1.61628814
109Delayed gross motor development (HP:0002194)1.61445051
110Abnormality of glycolysis (HP:0004366)1.60346170
111Metatarsus adductus (HP:0001840)1.60061306
112Abnormal mitochondria in muscle tissue (HP:0008316)1.51719887
113Acute necrotizing encephalopathy (HP:0006965)1.50936860
114Achilles tendon contracture (HP:0001771)1.50767409
115Increased serum pyruvate (HP:0003542)1.49834912
116Limited hip movement (HP:0008800)1.48942702

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.65199732
2TTN4.81381326
3MUSK4.23624983
4PHKG23.54657050
5PHKG13.54657050
6TRIB32.95423041
7NEK12.86491756
8MAPKAPK32.57900140
9PDK42.53191482
10PDK32.53191482
11MOS2.52093173
12PIK3CG2.37988619
13NME12.19411194
14STK242.09335281
15DMPK2.02899108
16PKN21.83297004
17PINK11.77354162
18LIMK11.70224053
19ILK1.69267671
20LMTK21.59431069
21LATS21.52698698
22MYLK1.49208558
23PDK21.43462324
24MAP2K31.38568996
25ERBB31.32340568
26CCNB11.28342048
27PIK3CA1.24126122
28MST1R1.22986879
29MAPK121.20248585
30MAP2K11.20106825
31KSR21.19474355
32TRPM71.13071943
33MAP3K71.04514538
34EIF2AK11.03007001
35TESK11.01565009
36STK38L0.99957378
37MAP2K40.98331191
38MET0.98069018
39VRK20.97694782
40ZAK0.95949702
41MAP3K50.91306782
42GRK50.89889518
43ROCK10.89021748
44ROCK20.83355305
45CAMK2D0.81268580
46ARAF0.80380681
47PAK60.75400136
48FER0.74200870
49TRIM280.74072192
50NEK90.73974785
51NTRK10.72538893
52CDK140.72309057
53PAK30.71272397
54PTK20.70886008
55PIM20.70313641
56LATS10.69687523
57CAMK2G0.67288839
58MINK10.66178340
59PTK2B0.65136985
60AKT20.64087366
61WEE10.63054196
62PRKAA10.62037558
63RPS6KB20.60967229
64MAP3K90.59229025
65RIPK10.57647538
66SCYL20.56990037
67RET0.56357843
68CAMK2A0.56338688
69NTRK30.55333531
70PNCK0.54525166
71CDK180.52808013
72CDK150.52381675
73MAPK110.51654383
74TGFBR20.50854585
75MARK10.48908159
76BRAF0.48465924
77NME20.47470531
78ICK0.46720714
79ERBB40.46207917
80TAF10.46103597
81CDK11A0.44815240
82PBK0.43032342
83MAP3K110.42949828
84PRKD10.42859284
85TAOK10.42588570
86IRAK30.42282070
87CAMK2B0.41977845
88BCKDK0.40288137
89MAP2K60.40189698
90PRKACB0.39618582
91STK380.39565468
92MAP3K30.38984054
93CDC42BPA0.38250086
94EPHB20.36821753
95EIF2AK30.36641823
96GRK70.35737791
97MAP3K40.35593523
98KSR10.34922788
99PLK20.34584894
100DAPK30.34360816
101PDGFRA0.33815322
102PRKD30.31637032
103PRKACA0.31556222
104CAMK40.31555430
105LRRK20.28875662
106STK160.28831966
107CAMK10.28049432
108RPS6KA20.27943149
109PRKG10.27369191
110GSK3A0.26839491
111PDPK10.26779616
112TAOK20.26364531
113PRKAA20.26179812
114MAPKAPK50.25854551
115MAP3K130.25543438
116MAP3K100.25435652
117MAPK70.25061153
118EPHA20.24800990
119MAP3K120.23995847
120MTOR0.23776980
121RPS6KA30.23418496
122SIK30.23006080
123MARK30.22875002
124PAK10.22618870
125MAP3K10.21802096
126PAK40.21500130
127BUB10.21278036
128RAF10.21083076
129CSNK1G30.20261718
130CSNK1A1L0.19544259
131EEF2K0.19538917
132TIE10.18596100
133PLK10.18498004
134ABL20.18433664
135BRSK20.18108914
136MAPK40.17719872
137MAPKAPK20.17648093
138CAMKK20.16691245
139DDR20.16181323

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.74380550
2Cardiac muscle contraction_Homo sapiens_hsa042604.46852029
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.33707961
4Dilated cardiomyopathy_Homo sapiens_hsa054144.06209296
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.49069319
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.10523585
7Parkinsons disease_Homo sapiens_hsa050122.86048556
8Oxidative phosphorylation_Homo sapiens_hsa001902.69934067
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.22739160
10Alzheimers disease_Homo sapiens_hsa050102.16117794
11Pentose phosphate pathway_Homo sapiens_hsa000302.06610097
12Huntingtons disease_Homo sapiens_hsa050161.85089423
13Carbon metabolism_Homo sapiens_hsa012001.83231167
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66423827
15Insulin signaling pathway_Homo sapiens_hsa049101.57729754
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55170146
17Propanoate metabolism_Homo sapiens_hsa006401.53584538
18Oxytocin signaling pathway_Homo sapiens_hsa049211.52936660
19Glucagon signaling pathway_Homo sapiens_hsa049221.42778616
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40335856
21Viral myocarditis_Homo sapiens_hsa054161.37098501
22Proteasome_Homo sapiens_hsa030501.35717594
23Tight junction_Homo sapiens_hsa045301.32652813
24Arginine biosynthesis_Homo sapiens_hsa002201.32022866
25Folate biosynthesis_Homo sapiens_hsa007901.30091959
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27788747
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24563345
28cGMP-PKG signaling pathway_Homo sapiens_hsa040221.23419975
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19755330
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14583026
31Calcium signaling pathway_Homo sapiens_hsa040201.13894412
32Focal adhesion_Homo sapiens_hsa045101.13257945
33Pyruvate metabolism_Homo sapiens_hsa006201.11952283
34Fatty acid degradation_Homo sapiens_hsa000711.05987842
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.02420867
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02172541
37HIF-1 signaling pathway_Homo sapiens_hsa040660.99771654
38Circadian rhythm_Homo sapiens_hsa047100.99602912
39Sulfur metabolism_Homo sapiens_hsa009200.98281008
40Biosynthesis of amino acids_Homo sapiens_hsa012300.97468737
41Vascular smooth muscle contraction_Homo sapiens_hsa042700.93747473
42Sulfur relay system_Homo sapiens_hsa041220.93432256
43AMPK signaling pathway_Homo sapiens_hsa041520.90977372
44Fructose and mannose metabolism_Homo sapiens_hsa000510.90295408
45Insulin resistance_Homo sapiens_hsa049310.90289736
46Starch and sucrose metabolism_Homo sapiens_hsa005000.88239394
47GnRH signaling pathway_Homo sapiens_hsa049120.87351132
48mTOR signaling pathway_Homo sapiens_hsa041500.84278081
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83845749
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.82737665
51Regulation of autophagy_Homo sapiens_hsa041400.82573348
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81584608
53Fatty acid metabolism_Homo sapiens_hsa012120.80773002
54Phenylalanine metabolism_Homo sapiens_hsa003600.77315898
55Insulin secretion_Homo sapiens_hsa049110.77107953
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75542802
57Glutathione metabolism_Homo sapiens_hsa004800.71191153
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69095465
59Adherens junction_Homo sapiens_hsa045200.68473792
60Proteoglycans in cancer_Homo sapiens_hsa052050.66641951
61Renin secretion_Homo sapiens_hsa049240.66614292
62Oocyte meiosis_Homo sapiens_hsa041140.66212074
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.66179783
64VEGF signaling pathway_Homo sapiens_hsa043700.65696033
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65610322
66FoxO signaling pathway_Homo sapiens_hsa040680.65324039
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65217419
68Gap junction_Homo sapiens_hsa045400.64267089
69beta-Alanine metabolism_Homo sapiens_hsa004100.63922380
70Gastric acid secretion_Homo sapiens_hsa049710.61295390
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60313360
72Dorso-ventral axis formation_Homo sapiens_hsa043200.59524197
73ECM-receptor interaction_Homo sapiens_hsa045120.57463995
74Renal cell carcinoma_Homo sapiens_hsa052110.56892680
75Galactose metabolism_Homo sapiens_hsa000520.56588181
76Tyrosine metabolism_Homo sapiens_hsa003500.56065862
77MAPK signaling pathway_Homo sapiens_hsa040100.55981204
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54936521
79Long-term potentiation_Homo sapiens_hsa047200.54482232
80Purine metabolism_Homo sapiens_hsa002300.54188367
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53268940
82Cholinergic synapse_Homo sapiens_hsa047250.52364824
83Circadian entrainment_Homo sapiens_hsa047130.52008410
84Amoebiasis_Homo sapiens_hsa051460.51076874
85Glioma_Homo sapiens_hsa052140.48230551
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47147184
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46880488
88Melanoma_Homo sapiens_hsa052180.46059872
89Taste transduction_Homo sapiens_hsa047420.45560335
90Protein export_Homo sapiens_hsa030600.44277831
91Thyroid cancer_Homo sapiens_hsa052160.43972541
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43429245
93Melanogenesis_Homo sapiens_hsa049160.43064315
94Dopaminergic synapse_Homo sapiens_hsa047280.42751952
95Nitrogen metabolism_Homo sapiens_hsa009100.42467827
96Salivary secretion_Homo sapiens_hsa049700.41937403
97Olfactory transduction_Homo sapiens_hsa047400.41478822
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40485895
99Hippo signaling pathway_Homo sapiens_hsa043900.39123007
100Metabolic pathways_Homo sapiens_hsa011000.39076079
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38546240
102Nucleotide excision repair_Homo sapiens_hsa034200.37107328
103Estrogen signaling pathway_Homo sapiens_hsa049150.36888077
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36882773
105Bladder cancer_Homo sapiens_hsa052190.35205735
106cAMP signaling pathway_Homo sapiens_hsa040240.35125317
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33885150
108Serotonergic synapse_Homo sapiens_hsa047260.33304592
109Endometrial cancer_Homo sapiens_hsa052130.33186550
110Synaptic vesicle cycle_Homo sapiens_hsa047210.32716726
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32685609
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.32042650
113Platelet activation_Homo sapiens_hsa046110.30900664
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30236573
115Endocytosis_Homo sapiens_hsa041440.30090012
116Arginine and proline metabolism_Homo sapiens_hsa003300.29248818
117Long-term depression_Homo sapiens_hsa047300.28699766
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28603722
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27940778
120Lysine degradation_Homo sapiens_hsa003100.26716623
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25476213
122Salmonella infection_Homo sapiens_hsa051320.25248484
123Fatty acid elongation_Homo sapiens_hsa000620.24921613
124Pyrimidine metabolism_Homo sapiens_hsa002400.23709716
125Axon guidance_Homo sapiens_hsa043600.23182515
126Vibrio cholerae infection_Homo sapiens_hsa051100.22459847
127Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.19808257
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19196878
129Small cell lung cancer_Homo sapiens_hsa052220.18855977
130Non-homologous end-joining_Homo sapiens_hsa034500.17688431
131Amphetamine addiction_Homo sapiens_hsa050310.16732189
132Peroxisome_Homo sapiens_hsa041460.15497519
133Mineral absorption_Homo sapiens_hsa049780.15336697

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