POR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.30837506
2L-phenylalanine catabolic process (GO:0006559)6.30837506
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.11551570
4L-phenylalanine metabolic process (GO:0006558)6.11551570
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.64410671
6aromatic amino acid family catabolic process (GO:0009074)5.47035426
7alpha-linolenic acid metabolic process (GO:0036109)5.22577426
8sulfur amino acid catabolic process (GO:0000098)5.18753546
9very-low-density lipoprotein particle assembly (GO:0034379)5.16015592
10cysteine metabolic process (GO:0006534)5.12675843
11glyoxylate metabolic process (GO:0046487)4.92630873
12high-density lipoprotein particle remodeling (GO:0034375)4.78305253
13urea cycle (GO:0000050)4.77695433
14urea metabolic process (GO:0019627)4.77695433
15bile acid biosynthetic process (GO:0006699)4.76715186
16tryptophan catabolic process (GO:0006569)4.74627383
17indole-containing compound catabolic process (GO:0042436)4.74627383
18indolalkylamine catabolic process (GO:0046218)4.74627383
19negative regulation of fibrinolysis (GO:0051918)4.70949094
20kynurenine metabolic process (GO:0070189)4.69906194
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.58991185
22tryptophan metabolic process (GO:0006568)4.49208593
23protein carboxylation (GO:0018214)4.48329196
24peptidyl-glutamic acid carboxylation (GO:0017187)4.48329196
25regulation of apoptotic cell clearance (GO:2000425)4.42078085
26regulation of triglyceride catabolic process (GO:0010896)4.42026940
27nitrogen cycle metabolic process (GO:0071941)4.41348082
28complement activation, alternative pathway (GO:0006957)4.40270016
29intestinal cholesterol absorption (GO:0030299)4.39368787
30reverse cholesterol transport (GO:0043691)4.39215994
31regulation of fibrinolysis (GO:0051917)4.38064909
32plasma lipoprotein particle clearance (GO:0034381)4.37195397
33regulation of cholesterol esterification (GO:0010872)4.33199106
34lysine metabolic process (GO:0006553)4.32560736
35lysine catabolic process (GO:0006554)4.32560736
36ethanol oxidation (GO:0006069)4.27165789
37regulation of plasminogen activation (GO:0010755)4.26251939
38cellular glucuronidation (GO:0052695)4.24157833
39bile acid metabolic process (GO:0008206)4.19369050
40blood coagulation, intrinsic pathway (GO:0007597)4.15348415
41proline metabolic process (GO:0006560)4.14277107
42plasma lipoprotein particle remodeling (GO:0034369)4.13982618
43protein-lipid complex remodeling (GO:0034368)4.13982618
44macromolecular complex remodeling (GO:0034367)4.13982618
45homocysteine metabolic process (GO:0050667)4.12790221
46serine family amino acid catabolic process (GO:0009071)4.11610216
47phospholipid efflux (GO:0033700)4.10593001
48regulation of protein activation cascade (GO:2000257)4.08309902
49drug catabolic process (GO:0042737)4.07097202
50omega-hydroxylase P450 pathway (GO:0097267)4.06872197
51* amino-acid betaine metabolic process (GO:0006577)4.06130777
52acylglycerol homeostasis (GO:0055090)4.03132290
53triglyceride homeostasis (GO:0070328)4.03132290
54negative regulation of sterol transport (GO:0032372)3.97872032
55negative regulation of cholesterol transport (GO:0032375)3.97872032
56uronic acid metabolic process (GO:0006063)3.96544550
57glucuronate metabolic process (GO:0019585)3.96544550
58tyrosine metabolic process (GO:0006570)3.95335591
59aromatic amino acid family metabolic process (GO:0009072)3.93920528
60protein-lipid complex subunit organization (GO:0071825)3.89469089
61xenobiotic catabolic process (GO:0042178)3.85158387
62regulation of cholesterol homeostasis (GO:2000188)3.84449091
63regulation of complement activation (GO:0030449)3.81923121
64alpha-amino acid catabolic process (GO:1901606)3.81216655
65positive regulation of fatty acid biosynthetic process (GO:0045723)3.81036044
66negative regulation of protein activation cascade (GO:2000258)3.77124704
67benzene-containing compound metabolic process (GO:0042537)3.74626942
68cholesterol efflux (GO:0033344)3.74586218
69valine metabolic process (GO:0006573)3.73282403
70cellular ketone body metabolic process (GO:0046950)3.72608183
71epoxygenase P450 pathway (GO:0019373)3.71201558
72positive regulation of fatty acid beta-oxidation (GO:0032000)3.70263953
73fatty acid beta-oxidation (GO:0006635)3.69204541
74positive regulation of lipid catabolic process (GO:0050996)3.65743183
75response to nitrosative stress (GO:0051409)3.64869210
76protein activation cascade (GO:0072376)3.64513321
77exogenous drug catabolic process (GO:0042738)3.63766405
78cellular modified amino acid catabolic process (GO:0042219)3.63478434
79cellular amino acid catabolic process (GO:0009063)3.63061209
80plasma lipoprotein particle assembly (GO:0034377)3.62553009
81low-density lipoprotein particle remodeling (GO:0034374)3.62430300
82* fatty acid oxidation (GO:0019395)3.61430405
83negative regulation of hemostasis (GO:1900047)3.61377275
84negative regulation of blood coagulation (GO:0030195)3.61377275
85short-chain fatty acid metabolic process (GO:0046459)3.61285736
86aldehyde catabolic process (GO:0046185)3.59860362
87drug metabolic process (GO:0017144)3.55463527
88* lipid oxidation (GO:0034440)3.55424623
89glutamate metabolic process (GO:0006536)3.54110592
902-oxoglutarate metabolic process (GO:0006103)3.53286785
91drug transmembrane transport (GO:0006855)3.52324631
92positive regulation of lipoprotein lipase activity (GO:0051006)3.51369151
93positive regulation of triglyceride lipase activity (GO:0061365)3.51369151
94monocarboxylic acid catabolic process (GO:0072329)3.51252775
95complement activation, classical pathway (GO:0006958)3.49998975
96phospholipid homeostasis (GO:0055091)3.49925281
97regulation of humoral immune response (GO:0002920)3.48797337
98low-density lipoprotein particle clearance (GO:0034383)3.48715805
99bile acid and bile salt transport (GO:0015721)3.47793863
100fatty acid catabolic process (GO:0009062)3.47759859
101serine family amino acid metabolic process (GO:0009069)3.45916040
102primary alcohol catabolic process (GO:0034310)3.44841653
103organic acid catabolic process (GO:0016054)3.43108019
104carboxylic acid catabolic process (GO:0046395)3.43108019
105cholesterol homeostasis (GO:0042632)3.42566586
106coenzyme catabolic process (GO:0009109)3.41288770
107fibrinolysis (GO:0042730)3.39775757
108positive regulation of blood coagulation (GO:0030194)3.38953699
109positive regulation of hemostasis (GO:1900048)3.38953699
110proline biosynthetic process (GO:0006561)3.38575601
111acetyl-CoA metabolic process (GO:0006084)3.38289310
112sterol homeostasis (GO:0055092)3.38221227
113complement activation (GO:0006956)3.36424730
114lipoprotein metabolic process (GO:0042157)3.34472579
115ethanol metabolic process (GO:0006067)3.33071628
116indolalkylamine metabolic process (GO:0006586)3.32447880
117positive regulation of triglyceride metabolic process (GO:0090208)3.31506635
118arginine metabolic process (GO:0006525)3.31498377
119fat-soluble vitamin biosynthetic process (GO:0042362)3.31177722
120protein-lipid complex assembly (GO:0065005)3.31141270
121acute-phase response (GO:0006953)3.30791635
122regulation of bile acid biosynthetic process (GO:0070857)3.29212765
123negative regulation of coagulation (GO:0050819)3.29196161
124plasma lipoprotein particle organization (GO:0071827)3.29183104
125glucose 6-phosphate metabolic process (GO:0051156)3.27545286
126intestinal absorption (GO:0050892)3.26264527
127negative regulation of fatty acid biosynthetic process (GO:0045717)3.24525092
128negative regulation of lipid transport (GO:0032369)3.23625041
129progesterone metabolic process (GO:0042448)3.23120036
130negative regulation of complement activation (GO:0045916)3.21399428
131positive regulation of coagulation (GO:0050820)3.21384197
132* regulation of cholesterol biosynthetic process (GO:0045540)3.19641284
133regulation of fatty acid biosynthetic process (GO:0042304)3.19537552
134negative regulation of wound healing (GO:0061045)3.19379248
135positive regulation of extracellular matrix organization (GO:1903055)3.17471459
136glutamine family amino acid biosynthetic process (GO:0009084)3.12129558
137polyketide metabolic process (GO:0030638)3.10650156
138doxorubicin metabolic process (GO:0044598)3.10650156
139daunorubicin metabolic process (GO:0044597)3.10650156
140regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.10599726
141Golgi transport vesicle coating (GO:0048200)3.08605213
142COPI coating of Golgi vesicle (GO:0048205)3.08605213
143phenylpropanoid metabolic process (GO:0009698)3.07240711

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.80550189
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.10532625
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.13019245
4* PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.98936367
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.59498372
6EGR1_23403033_ChIP-Seq_LIVER_Mouse5.06853048
7* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.38301800
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.09723342
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.31916279
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.20890466
11* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.63485445
12CLOCK_20551151_ChIP-Seq_293T_Human2.62187725
13GATA1_22025678_ChIP-Seq_K562_Human2.17972460
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08643911
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.07202159
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.82752668
17* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.81702592
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70395385
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66836432
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58980093
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.52992325
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52954648
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.51126917
24SOX2_27498859_Chip-Seq_STOMACH_Mouse1.46867811
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.45996244
26* SMC4_20622854_ChIP-Seq_HELA_Human1.45060849
27* FOXA2_19822575_ChIP-Seq_HepG2_Human1.44488644
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43779794
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42655615
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.41250024
31VDR_21846776_ChIP-Seq_THP-1_Human1.40547535
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38328519
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37794832
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37427318
35P68_20966046_ChIP-Seq_HELA_Human1.36547485
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31748326
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.30748195
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30290935
39* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29399285
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.28807978
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27317684
42KDM2B_26808549_Chip-Seq_K562_Human1.27098209
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.26683677
44UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24625067
45* HNF4A_19822575_ChIP-Seq_HepG2_Human1.20116895
46TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19928358
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19766883
48TCF7_22412390_ChIP-Seq_EML_Mouse1.19711956
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18655247
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17726995
51SA1_27219007_Chip-Seq_ERYTHROID_Human1.16717868
52* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16648773
53GATA4_25053715_ChIP-Seq_YYC3_Human1.15984293
54LXR_22292898_ChIP-Seq_THP-1_Human1.15558481
55ZNF263_19887448_ChIP-Seq_K562_Human1.15221059
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14880214
57CREB1_26743006_Chip-Seq_LNCaP_Human1.13766442
58RUNX1_27514584_Chip-Seq_MCF-7_Human1.12532415
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11420782
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07933215
61HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07628168
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07437230
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05583064
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05214014
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04753528
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04558793
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.04028551
68MYC_22102868_ChIP-Seq_BL_Human1.03881185
69KDM2B_26808549_Chip-Seq_DND41_Human1.03216575
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02079981
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00314194
72RACK7_27058665_Chip-Seq_MCF-7_Human0.97411893
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96405272
74* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96322069
75NCOR1_26117541_ChIP-Seq_K562_Human0.95494048
76GATA1_19941826_ChIP-Seq_K562_Human0.95295827
77TP53_22127205_ChIP-Seq_IMR90_Human0.94890913
78* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93777596
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93171408
80CTCF_27219007_Chip-Seq_Bcells_Human0.92943654
81GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92804351
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91190503
83* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91110730
84SOX2_20726797_ChIP-Seq_SW620_Human0.91088826
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90834367
86PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90747365
87CDX2_20551321_ChIP-Seq_CACO-2_Human0.90690429
88P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90575519
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89394725
90FOXO3_23340844_ChIP-Seq_DLD1_Human0.87351135
91* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87287309
92GATA2_21666600_ChIP-Seq_HMVEC_Human0.86065864
93RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85971200
94AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84480631
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81958340
96* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79781251
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79404564
98GATA2_19941826_ChIP-Seq_K562_Human0.78909958
99GATA6_25053715_ChIP-Seq_YYC3_Human0.78013179
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77970905
101PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75388483
102NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74702543
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74702543
104RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.73947416
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73410848
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.73129018
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.71990493
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.71980617
109BRD4_27068464_Chip-Seq_AML-cells_Mouse0.71557821
110ELK3_25401928_ChIP-Seq_HUVEC_Human0.71388219
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70761298
112ESR1_20079471_ChIP-ChIP_T-47D_Human0.70126722
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.70083570
114HTT_18923047_ChIP-ChIP_STHdh_Human0.69966995
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69791261
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.69713178
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69080672
118FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68269499
119* GATA1_19941827_ChIP-Seq_MEL_Mouse0.67950150
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67694993
121GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.67399497
122P63_26484246_Chip-Seq_KERATINOCYTES_Human0.66902080
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.66028455
124ATF3_27146783_Chip-Seq_COLON_Human0.65370962
125RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64539551
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.64492748
127SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63308651
128* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.63145362
129* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.63137059
130RARA_24833708_ChIP-Seq_LIVER_Mouse0.62615115
131HIF1A_21447827_ChIP-Seq_MCF-7_Human0.60796598
132GATA3_24758297_ChIP-Seq_MCF-7_Human0.59661588
133FOXA1_25552417_ChIP-Seq_VCAP_Human0.59269306
134* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.59021838
135TBX20_22080862_ChIP-Seq_HEART_Mouse0.59014563
136TBX20_22328084_ChIP-Seq_HEART_Mouse0.59014563
137* IRF8_27001747_Chip-Seq_BMDM_Mouse0.58915452
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58474323
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.58265295
140BCOR_27268052_Chip-Seq_Bcells_Human0.57629817
141RARB_24833708_ChIP-Seq_LIVER_Mouse0.57354716
142* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.57048807

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.34724644
2MP0005360_urolithiasis6.45314898
3MP0005085_abnormal_gallbladder_physiolo5.16584727
4* MP0005365_abnormal_bile_salt5.06618307
5* MP0008875_abnormal_xenobiotic_pharmacok4.97798773
6MP0009840_abnormal_foam_cell3.60958011
7MP0010329_abnormal_lipoprotein_level3.53324031
8MP0003806_abnormal_nucleotide_metabolis3.38481915
9MP0003252_abnormal_bile_duct3.19031210
10MP0003191_abnormal_cellular_cholesterol2.93035954
11MP0005083_abnormal_biliary_tract2.80852579
12MP0005332_abnormal_amino_acid2.71189961
13MP0003195_calcinosis2.54883610
14MP0001666_abnormal_nutrient_absorption2.38984751
15MP0004019_abnormal_vitamin_homeostasis2.27004815
16MP0002118_abnormal_lipid_homeostasis2.16940355
17MP0000609_abnormal_liver_physiology2.14860234
18MP0002138_abnormal_hepatobiliary_system2.01047521
19MP0005670_abnormal_white_adipose1.95485614
20* MP0005319_abnormal_enzyme/_coenzyme1.82220726
21MP0003186_abnormal_redox_activity1.79035985
22MP0000566_synostosis1.78922304
23MP0008260_abnormal_autophagy1.72980787
24MP0009643_abnormal_urine_homeostasis1.65007230
25MP0003172_abnormal_lysosome_physiology1.63367713
26MP0005076_abnormal_cell_differentiation1.51749731
27* MP0005584_abnormal_enzyme/coenzyme_acti1.47236514
28MP0001764_abnormal_homeostasis1.44869580
29MP0002089_abnormal_postnatal_growth/wei1.44321313
30MP0004858_abnormal_nervous_system1.42126291
31MP0003705_abnormal_hypodermis_morpholog1.41556482
32MP0003868_abnormal_feces_composition1.32275811
33MP0002132_abnormal_respiratory_system1.32170991
34MP0005058_abnormal_lysosome_morphology1.30351688
35MP0003122_maternal_imprinting1.28288933
36MP0000604_amyloidosis1.26114586
37MP0002254_reproductive_system_inflammat1.25292545
38MP0004130_abnormal_muscle_cell1.23056055
39MP0003656_abnormal_erythrocyte_physiolo1.22818880
40MP0009764_decreased_sensitivity_to1.19302602
41MP0005409_darkened_coat_color1.18728186
42MP0003011_delayed_dark_adaptation1.18335608
43* MP0000598_abnormal_liver_morphology1.17191279
44MP0005666_abnormal_adipose_tissue1.17020383
45MP0004272_abnormal_basement_membrane1.15594118
46MP0005451_abnormal_body_composition1.12831116
47MP0005636_abnormal_mineral_homeostasis1.10833451
48MP0001849_ear_inflammation1.07407029
49MP0003453_abnormal_keratinocyte_physiol1.06637306
50MP0010368_abnormal_lymphatic_system1.06018140
51MP0002971_abnormal_brown_adipose1.01431143
52MP0001756_abnormal_urination1.00669569
53* MP0008469_abnormal_protein_level0.99993910
54MP0009763_increased_sensitivity_to0.99604888
55MP0005257_abnormal_intraocular_pressure0.99133732
56MP0000681_abnormal_thyroid_gland0.97947260
57MP0003300_gastrointestinal_ulcer0.97940501
58MP0000858_altered_metastatic_potential0.97439343
59* MP0001915_intracranial_hemorrhage0.97434569
60MP0005334_abnormal_fat_pad0.97217441
61MP0003123_paternal_imprinting0.97178920
62MP0000678_abnormal_parathyroid_gland0.96966604
63MP0002078_abnormal_glucose_homeostasis0.96887220
64MP0002249_abnormal_larynx_morphology0.93728779
65MP0003690_abnormal_glial_cell0.93724899
66MP0009642_abnormal_blood_homeostasis0.93284619
67MP0003724_increased_susceptibility_to0.90929109
68MP0003879_abnormal_hair_cell0.90563389
69MP0002796_impaired_skin_barrier0.90184646
70MP0003436_decreased_susceptibility_to0.87730929
71MP0000003_abnormal_adipose_tissue0.86300444
72* MP0003566_abnormal_cell_adhesion0.83553358
73MP0004782_abnormal_surfactant_physiolog0.82666842
74MP0005464_abnormal_platelet_physiology0.82425100
75MP0002136_abnormal_kidney_physiology0.82009791
76MP0005535_abnormal_body_temperature0.80514716
77MP0003075_altered_response_to0.80342595
78MP0005376_homeostasis/metabolism_phenot0.79516821
79MP0005647_abnormal_sex_gland0.76228244
80MP0009697_abnormal_copulation0.75580456
81MP0003329_amyloid_beta_deposits0.75555040
82MP0004233_abnormal_muscle_weight0.73973859
83MP0009765_abnormal_xenobiotic_induced0.73539175
84MP0009115_abnormal_fat_cell0.73408636
85MP0005084_abnormal_gallbladder_morpholo0.72985745
86MP0005220_abnormal_exocrine_pancreas0.72815740
87MP0003183_abnormal_peptide_metabolism0.72407812
88MP0005167_abnormal_blood-brain_barrier0.72180438
89MP0006036_abnormal_mitochondrial_physio0.71527676
90MP0005375_adipose_tissue_phenotype0.69366559
91MP0010234_abnormal_vibrissa_follicle0.68452068
92MP0002876_abnormal_thyroid_physiology0.68142568
93MP0005448_abnormal_energy_balance0.67967016
94MP0004185_abnormal_adipocyte_glucose0.66932435
95MP0003878_abnormal_ear_physiology0.65647801
96MP0005377_hearing/vestibular/ear_phenot0.65647801
97MP0002837_dystrophic_cardiac_calcinosis0.65133059
98MP0004043_abnormal_pH_regulation0.62109766
99MP0009672_abnormal_birth_weight0.61294625
100MP0005501_abnormal_skin_physiology0.60604519
101MP0003638_abnormal_response/metabolism_0.59774600
102MP0002970_abnormal_white_adipose0.58721805
103MP0005164_abnormal_response_to0.58711033
104MP0001661_extended_life_span0.58236557
105MP0000249_abnormal_blood_vessel0.57326547
106MP0001853_heart_inflammation0.56435782
107MP0005266_abnormal_metabolism0.55998947
108MP0009780_abnormal_chondrocyte_physiolo0.55754218
109MP0002098_abnormal_vibrissa_morphology0.55260750
110MP0003953_abnormal_hormone_level0.53674355
111MP0005166_decreased_susceptibility_to0.53205117
112MP0001765_abnormal_ion_homeostasis0.53153066
113MP0005408_hypopigmentation0.52933524
114MP0003941_abnormal_skin_development0.52106505
115MP0002909_abnormal_adrenal_gland0.51561490
116MP0003303_peritoneal_inflammation0.51447214
117MP0005023_abnormal_wound_healing0.51403795
118MP0002168_other_aberrant_phenotype0.51272152
119MP0002928_abnormal_bile_duct0.51056753
120MP0001845_abnormal_inflammatory_respons0.50301816
121MP0005248_abnormal_Harderian_gland0.50155515
122MP0008438_abnormal_cutaneous_collagen0.50044001
123MP0000467_abnormal_esophagus_morphology0.49202221
124MP0009333_abnormal_splenocyte_physiolog0.49163356
125MP0004264_abnormal_extraembryonic_tissu0.48996362
126MP0001533_abnormal_skeleton_physiology0.48827605
127MP0009053_abnormal_anal_canal0.48255115
128MP0000230_abnormal_systemic_arterial0.47575943
129MP0008961_abnormal_basal_metabolism0.46826495
130MP0004947_skin_inflammation0.46515305
131MP0008873_increased_physiological_sensi0.46460774
132MP0001881_abnormal_mammary_gland0.45496078
133MP0000343_altered_response_to0.45440085
134MP0000639_abnormal_adrenal_gland0.45052034
135MP0002060_abnormal_skin_morphology0.44686758
136MP0001944_abnormal_pancreas_morphology0.44683216

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.30708040
2Deep venous thrombosis (HP:0002625)6.10326418
3Xanthomatosis (HP:0000991)5.79305075
4Intrahepatic cholestasis (HP:0001406)5.66901911
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.64779966
6Hyperlipoproteinemia (HP:0010980)5.00861586
7Hypobetalipoproteinemia (HP:0003563)4.97563825
8Prolonged partial thromboplastin time (HP:0003645)4.88003488
9Complement deficiency (HP:0004431)4.44320942
10Ketosis (HP:0001946)4.33395941
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.31055734
12Hyperglycinuria (HP:0003108)4.22313667
13Hyperammonemia (HP:0001987)4.20613420
14Hypolipoproteinemia (HP:0010981)4.15424185
15Hypoglycemic coma (HP:0001325)4.06335531
16Hypoalphalipoproteinemia (HP:0003233)4.01101753
17Joint hemorrhage (HP:0005261)4.00504413
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.91482615
19Abnormality of glycine metabolism (HP:0010895)3.86236665
20Abnormality of serine family amino acid metabolism (HP:0010894)3.86236665
21Abnormality of the common coagulation pathway (HP:0010990)3.83957557
22Epidermoid cyst (HP:0200040)3.77502079
23Ketoacidosis (HP:0001993)3.65720003
24Hyperglycinemia (HP:0002154)3.61508183
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.58623283
26Hypercholesterolemia (HP:0003124)3.54914619
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.49467741
28Abnormality of fatty-acid metabolism (HP:0004359)3.48527578
29Fat malabsorption (HP:0002630)3.37441807
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32999348
31Abnormality of the intrinsic pathway (HP:0010989)3.29550276
32Abnormality of complement system (HP:0005339)3.29187595
33Abnormality of methionine metabolism (HP:0010901)3.24106522
34Gout (HP:0001997)3.17943900
35Abnormality of purine metabolism (HP:0004352)3.16829384
36Abnormality of nucleobase metabolism (HP:0010932)3.05567120
37Myocardial infarction (HP:0001658)2.98852932
38Conjugated hyperbilirubinemia (HP:0002908)2.94589306
39Abnormality of pyrimidine metabolism (HP:0004353)2.83042591
40Hyperbilirubinemia (HP:0002904)2.80463225
41Hepatocellular carcinoma (HP:0001402)2.75874920
42Abnormality of the Achilles tendon (HP:0005109)2.71199428
43Systemic lupus erythematosus (HP:0002725)2.69418454
44Abnormality of proline metabolism (HP:0010907)2.69413703
45Hydroxyprolinuria (HP:0003080)2.69413703
46Metabolic acidosis (HP:0001942)2.67776673
47Amyloidosis (HP:0011034)2.67499897
48Delayed CNS myelination (HP:0002188)2.67104220
49Purpura (HP:0000979)2.66799553
50Hypoglycemic seizures (HP:0002173)2.64513892
51Dicarboxylic aciduria (HP:0003215)2.64102881
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64102881
53Skin nodule (HP:0200036)2.60156937
54Vertebral compression fractures (HP:0002953)2.57675022
55Late onset (HP:0003584)2.57168261
56Steatorrhea (HP:0002570)2.54796148
57Generalized aminoaciduria (HP:0002909)2.50805241
58Esophageal varix (HP:0002040)2.48769762
59Flat acetabular roof (HP:0003180)2.45150021
60Vascular calcification (HP:0004934)2.41682192
61Abnormality of serum amino acid levels (HP:0003112)2.39711710
62Abnormality of carpal bone ossification (HP:0006257)2.39473940
63Abnormality of polysaccharide metabolism (HP:0011012)2.38440359
64Abnormality of glycosaminoglycan metabolism (HP:0004371)2.38440359
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.38440359
66Rickets (HP:0002748)2.33031388
67Spastic diplegia (HP:0001264)2.32505679
68Lethargy (HP:0001254)2.31917917
69Irritability (HP:0000737)2.29945627
70Glomerulonephritis (HP:0000099)2.24217483
71Pancreatitis (HP:0001733)2.22916964
72Sensorimotor neuropathy (HP:0007141)2.22733990
73Increased purine levels (HP:0004368)2.21764766
74Hyperuricemia (HP:0002149)2.21764766
75Spontaneous abortion (HP:0005268)2.20382973
76Hypertriglyceridemia (HP:0002155)2.19472677
77Menorrhagia (HP:0000132)2.18847097
78Cardiovascular calcification (HP:0011915)2.18319599
79Recurrent gram-negative bacterial infections (HP:0005420)2.16291293
80Malnutrition (HP:0004395)2.15644962
81Mitral stenosis (HP:0001718)2.14068313
82Hemorrhage of the eye (HP:0011885)2.10015168
83Abnormal gallbladder physiology (HP:0012438)2.09934105
84Cholecystitis (HP:0001082)2.09934105
85Brushfield spots (HP:0001088)2.09933605
86Polycythemia (HP:0001901)2.09517178
87Hyperinsulinemic hypoglycemia (HP:0000825)2.09170124
88Abnormal cartilage morphology (HP:0002763)2.08709212
89Vomiting (HP:0002013)2.07765274
90Dysostosis multiplex (HP:0000943)2.05212651
91Neonatal onset (HP:0003623)2.03661026
92Abnormal gallbladder morphology (HP:0012437)2.03483939
93Proximal tubulopathy (HP:0000114)2.02680728
94Achilles tendon contracture (HP:0001771)2.02432523
95Abnormality of transition element cation homeostasis (HP:0011030)2.02386267
96Back pain (HP:0003418)2.02365416
97Gingival bleeding (HP:0000225)2.01717229
98Elevated alkaline phosphatase (HP:0003155)1.99574455
99Alkalosis (HP:0001948)1.99461139
100Abnormality of iron homeostasis (HP:0011031)1.99394333
101Abnormality of alkaline phosphatase activity (HP:0004379)1.98650005
102Cholelithiasis (HP:0001081)1.98283855
103Reticulocytosis (HP:0001923)1.96901233
104Neurofibrillary tangles (HP:0002185)1.96519211
105Abnormality of glycolysis (HP:0004366)1.94833906
106Mucopolysacchariduria (HP:0008155)1.94661778
107Urinary glycosaminoglycan excretion (HP:0003541)1.94661778
108Abnormal tarsal ossification (HP:0008369)1.94031901
109Acanthocytosis (HP:0001927)1.93785153
110Hyperglycemia (HP:0003074)1.92547039
111Pathologic fracture (HP:0002756)1.91131244
112Protrusio acetabuli (HP:0003179)1.91089520
113Abnormal enzyme/coenzyme activity (HP:0012379)1.91002002
114Osteomalacia (HP:0002749)1.90104813
115Abnormal ossification of hand bones (HP:0005921)1.88053185
116Distal upper limb amyotrophy (HP:0007149)1.87558660
117Upper limb amyotrophy (HP:0009129)1.87558660
118Vacuolated lymphocytes (HP:0001922)1.87386543
119Nephritis (HP:0000123)1.86811791
120Increased serum pyruvate (HP:0003542)1.86663330
121Increased serum ferritin (HP:0003281)1.85795080
122Symptomatic seizures (HP:0011145)1.83229215
123Thrombophlebitis (HP:0004418)1.83029372
124Nausea (HP:0002018)1.82239968
125Enlarged kidneys (HP:0000105)1.81486223
126Opisthotonus (HP:0002179)1.81134010
127Cerebral inclusion bodies (HP:0100314)1.79403244
128Small epiphyses (HP:0010585)1.77898606
129Abnormality of glycolipid metabolism (HP:0010969)1.75501594
130Abnormality of liposaccharide metabolism (HP:0010968)1.75501594
131Abnormality of glycosphingolipid metabolism (HP:0004343)1.75501594
132Paraparesis (HP:0002385)1.74711511
133Widely patent fontanelles and sutures (HP:0004492)1.73035176
134Asymmetry of the thorax (HP:0001555)1.68978431
135Retinal atrophy (HP:0001105)1.67038456
136Cerebral aneurysm (HP:0004944)1.63839646
137Growth hormone excess (HP:0000845)1.59997033
138Loss of speech (HP:0002371)1.58786590
139Hand muscle atrophy (HP:0009130)1.58698765
140Hypophosphatemia (HP:0002148)1.57371257
141Abnormal hand bone ossification (HP:0010660)1.57124490
142Abdominal distention (HP:0003270)1.56167756
143Cervical subluxation (HP:0003308)1.54882456

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.26764994
2ERN14.69370807
3TRIB33.93046321
4SIK13.76330367
5ICK3.58352648
6INSRR3.17038465
7FGFR43.15011796
8SMG12.82262895
9TAOK32.71725793
10MST1R2.49875273
11PKN22.45999344
12EEF2K2.28212282
13CDK122.15957184
14FLT31.99939290
15RIPK11.88276926
16PRPF4B1.87701852
17PTK61.83795689
18CAMK1D1.72664908
19EPHB11.66451450
20MAP3K31.53599128
21MAPK151.52072650
22EPHA21.51735231
23TGFBR21.49575955
24TBK11.49005821
25TESK11.47976922
26ERBB41.42188876
27MAP2K31.35727802
28FRK1.35606877
29TYK21.31434539
30DDR21.24701024
31TIE11.18823257
32PTK21.16406191
33TESK21.14898962
34GRK61.14649726
35MET1.14184527
36KDR1.14121081
37LATS21.10866518
38JAK21.07107367
39NME21.06822965
40CAMK1G1.06562758
41KIT1.05953410
42MAPK111.04948143
43ABL21.04011097
44LATS11.03360056
45IRAK31.02568482
46MAP3K21.02013698
47MAP3K110.98286765
48LRRK20.95527526
49MAP2K20.93958856
50PIK3CG0.93465119
51MAPKAPK30.92555427
52EPHA30.92536238
53CDC42BPA0.92335210
54NEK90.92228895
55PDK20.91367028
56ARAF0.88090442
57ZAP700.87336313
58TYRO30.87222936
59MAP2K10.87165859
60PIM20.86879920
61CSK0.86639387
62PDGFRA0.86442764
63MAP2K40.85031074
64JAK10.84018751
65MARK20.80810127
66MAP3K70.80496607
67PRKAA20.79407727
68BMX0.76916634
69DYRK1B0.76222964
70CDK70.73891361
71CDK60.72319706
72FER0.71030639
73GSK3A0.68963431
74JAK30.68549768
75MAP3K10.68468881
76MAP3K100.67625014
77MAPK40.65698296
78MAP3K60.65158127
79PDPK10.64772342
80ERBB20.63411710
81BTK0.63096842
82WNK40.62666032
83DAPK20.62520407
84RPS6KA20.61964467
85CSF1R0.60030464
86EPHB20.59956946
87LMTK20.58592464
88FGFR30.55023161
89MAP3K80.54779512
90PRKD20.54416991
91PAK40.53750091
92AKT20.53347668
93NTRK10.53310312
94IKBKE0.53114875
95PRKG20.53064751
96MAP3K140.52195533
97PINK10.50180606
98MAP4K10.49602687
99PRKACG0.49492793
100TTN0.47826292
101AKT30.46578495
102PRKCZ0.45829693
103IGF1R0.45209995
104FGR0.44820093
105RET0.43423617
106FGFR20.42888611
107SGK30.41227107
108EGFR0.38892010
109MTOR0.38281105
110CDK40.37850308
111TGFBR10.37775422
112WNK30.36727774
113NEK60.35977131
114RPS6KB20.35667593
115FGFR10.35053299
116MYLK0.34391233
117CDK90.33855882
118PAK30.33447242
119ABL10.33208713
120SIK20.32596745
121MAPK120.32511091
122SRC0.31571765
123PRKD10.31532930
124MATK0.31458256
125MAP2K60.30416322
126RPS6KL10.29950908
127RPS6KC10.29950908
128PRKAA10.29907012
129KSR20.29695494
130PDK40.29412258
131PDK30.29412258
132SCYL20.28202755
133STK380.28054627
134TAOK20.27896601
135CAMK2G0.27637409
136MAPKAPK20.27516408
137TAOK10.27235876
138PRKCH0.26666996
139CHUK0.26455410
140RPS6KA10.26006487
141PDK10.24957159
142PRKCI0.23867617
143LIMK10.23561869

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.71701897
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.54661277
3Nitrogen metabolism_Homo sapiens_hsa009103.01084978
4Fatty acid degradation_Homo sapiens_hsa000712.68259270
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.67741309
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.64472292
7Arginine biosynthesis_Homo sapiens_hsa002202.60425724
8Tryptophan metabolism_Homo sapiens_hsa003802.52731492
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49181717
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45861628
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.41428469
12Complement and coagulation cascades_Homo sapiens_hsa046102.37584173
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33955105
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.20092852
15Caffeine metabolism_Homo sapiens_hsa002322.16205866
16Chemical carcinogenesis_Homo sapiens_hsa052042.15885085
17PPAR signaling pathway_Homo sapiens_hsa033202.15078321
18Butanoate metabolism_Homo sapiens_hsa006502.12363091
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09989570
20Propanoate metabolism_Homo sapiens_hsa006402.07119877
21Peroxisome_Homo sapiens_hsa041462.03534229
22Fatty acid metabolism_Homo sapiens_hsa012121.97420322
23Histidine metabolism_Homo sapiens_hsa003401.87852179
24beta-Alanine metabolism_Homo sapiens_hsa004101.86298446
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.76679232
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.74531920
27Sulfur metabolism_Homo sapiens_hsa009201.71308848
28Staphylococcus aureus infection_Homo sapiens_hsa051501.65169290
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.64801386
30Retinol metabolism_Homo sapiens_hsa008301.64460240
31Phenylalanine metabolism_Homo sapiens_hsa003601.50826925
32Starch and sucrose metabolism_Homo sapiens_hsa005001.50600207
33Selenocompound metabolism_Homo sapiens_hsa004501.49971413
34Bile secretion_Homo sapiens_hsa049761.49290433
35Pyruvate metabolism_Homo sapiens_hsa006201.44689984
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42321317
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35873946
38Tyrosine metabolism_Homo sapiens_hsa003501.28879978
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27274790
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26726720
41Fat digestion and absorption_Homo sapiens_hsa049751.26566818
42ABC transporters_Homo sapiens_hsa020101.25006348
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.22741294
44Folate biosynthesis_Homo sapiens_hsa007901.19744505
45Carbon metabolism_Homo sapiens_hsa012001.18463413
46Sulfur relay system_Homo sapiens_hsa041221.14165094
47Fatty acid elongation_Homo sapiens_hsa000621.12575220
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09186673
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.08948212
50Biosynthesis of amino acids_Homo sapiens_hsa012301.07296282
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05302108
52Glutathione metabolism_Homo sapiens_hsa004801.03026690
53Vitamin digestion and absorption_Homo sapiens_hsa049770.97052907
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95356535
55Glycerolipid metabolism_Homo sapiens_hsa005610.92217999
56Steroid biosynthesis_Homo sapiens_hsa001000.91834036
57Arginine and proline metabolism_Homo sapiens_hsa003300.90266978
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88698477
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.85869781
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79459306
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79114986
62Fatty acid biosynthesis_Homo sapiens_hsa000610.78130035
63Lysine degradation_Homo sapiens_hsa003100.74820182
64Pentose phosphate pathway_Homo sapiens_hsa000300.74177402
65Sphingolipid metabolism_Homo sapiens_hsa006000.63417316
66Galactose metabolism_Homo sapiens_hsa000520.55307705
67Vitamin B6 metabolism_Homo sapiens_hsa007500.54891316
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.49938539
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49196591
70N-Glycan biosynthesis_Homo sapiens_hsa005100.47804370
71Insulin resistance_Homo sapiens_hsa049310.46012325
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.42025146
73Fructose and mannose metabolism_Homo sapiens_hsa000510.40161919
74Metabolic pathways_Homo sapiens_hsa011000.40077444
75Vibrio cholerae infection_Homo sapiens_hsa051100.36791872
76Lysosome_Homo sapiens_hsa041420.28850340
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27854381
78One carbon pool by folate_Homo sapiens_hsa006700.26145873
79Prion diseases_Homo sapiens_hsa050200.24494968
80AMPK signaling pathway_Homo sapiens_hsa041520.18026646
81Other glycan degradation_Homo sapiens_hsa005110.16048822
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.13957703
83Glucagon signaling pathway_Homo sapiens_hsa049220.13540909
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13251167
85Renin-angiotensin system_Homo sapiens_hsa046140.11241676
86Mineral absorption_Homo sapiens_hsa049780.10647467
87Thyroid cancer_Homo sapiens_hsa052160.10366483
88Acute myeloid leukemia_Homo sapiens_hsa052210.07839135
89Notch signaling pathway_Homo sapiens_hsa043300.06104964
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05718544
91Linoleic acid metabolism_Homo sapiens_hsa005910.05492303
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.05218378
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04341476
94Insulin signaling pathway_Homo sapiens_hsa049100.02560522
95Protein digestion and absorption_Homo sapiens_hsa04974-0.1032330
96Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0993852
97Amoebiasis_Homo sapiens_hsa05146-0.0917713
98Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0733481
99Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0671108
100Hepatitis C_Homo sapiens_hsa05160-0.0506481
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0505997
102Pertussis_Homo sapiens_hsa05133-0.0462723
103Bladder cancer_Homo sapiens_hsa05219-0.0444675
104Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0373546
105Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0312307
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0292529
107Chronic myeloid leukemia_Homo sapiens_hsa05220-0.0288802
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0183203

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