PORCN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the porcupine family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Disruption of this gene is associated with focal dermal hypoplasia, and the encoded protein has been implicated in cancer. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.01433797
2glucocorticoid biosynthetic process (GO:0006704)6.58611098
3amyloid precursor protein catabolic process (GO:0042987)6.05176869
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.83153423
5cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.78644980
6synaptic vesicle exocytosis (GO:0016079)5.42127796
7vocalization behavior (GO:0071625)5.34043977
8locomotory exploration behavior (GO:0035641)5.32799693
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.31872538
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.23515386
11positive regulation of astrocyte differentiation (GO:0048711)5.07589144
12synaptic vesicle maturation (GO:0016188)5.01048182
13glutamate secretion (GO:0014047)4.97555539
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.94454941
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.90995655
16glutamate receptor signaling pathway (GO:0007215)4.90418715
17neuronal action potential propagation (GO:0019227)4.87918337
18cerebellar granule cell differentiation (GO:0021707)4.82269648
19glucocorticoid metabolic process (GO:0008211)4.81578166
20positive regulation of synapse maturation (GO:0090129)4.79841789
21G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.79306021
22regulation of transforming growth factor beta2 production (GO:0032909)4.78489245
23desmosome organization (GO:0002934)4.75837091
24protein localization to synapse (GO:0035418)4.72798278
25synaptic transmission, glutamatergic (GO:0035249)4.67340677
26regulation of synaptic vesicle exocytosis (GO:2000300)4.64134357
27cellular response to gonadotropin stimulus (GO:0071371)4.46672914
28regulation of glutamate receptor signaling pathway (GO:1900449)4.44309245
29neuron cell-cell adhesion (GO:0007158)4.42015643
30cellular potassium ion homeostasis (GO:0030007)4.39190505
31synaptic vesicle docking involved in exocytosis (GO:0016081)4.38465366
32neuron-neuron synaptic transmission (GO:0007270)4.34780753
33neurotransmitter secretion (GO:0007269)4.33498679
34amyloid precursor protein metabolic process (GO:0042982)4.32747593
35substrate-dependent cell migration (GO:0006929)4.26646667
36response to follicle-stimulating hormone (GO:0032354)4.26578119
37gamma-aminobutyric acid signaling pathway (GO:0007214)4.24358662
38Golgi transport vesicle coating (GO:0048200)4.21855977
39COPI coating of Golgi vesicle (GO:0048205)4.21855977
40gamma-aminobutyric acid transport (GO:0015812)4.19873850
41low-density lipoprotein particle clearance (GO:0034383)4.18548236
42regulation of synaptic vesicle transport (GO:1902803)4.17602619
43neurotransmitter-gated ion channel clustering (GO:0072578)4.17052373
44maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.16771103
45androgen biosynthetic process (GO:0006702)4.16725662
46protein retention in ER lumen (GO:0006621)4.16667146
47exploration behavior (GO:0035640)4.09560492
48estrogen biosynthetic process (GO:0006703)4.09034309
49regulation of neuronal synaptic plasticity (GO:0048168)4.04725605
50long-term memory (GO:0007616)3.95626495
51regulation of long-term neuronal synaptic plasticity (GO:0048169)3.93902906
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.89194268
53cerebellar Purkinje cell differentiation (GO:0021702)3.88232333
54response to gonadotropin (GO:0034698)3.84695831
55regulation of gonadotropin secretion (GO:0032276)3.83368637
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.79392507
57sodium ion export (GO:0071436)3.78361868
58regulation of excitatory postsynaptic membrane potential (GO:0060079)3.77504205
59transmission of nerve impulse (GO:0019226)3.74804428
60regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.73282678
61synaptic vesicle endocytosis (GO:0048488)3.72968551
62adhesion of symbiont to host (GO:0044406)3.72177120
63regulation of synapse maturation (GO:0090128)3.71837589
64dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.71315679
65response to pheromone (GO:0019236)3.70943711
66neuromuscular process controlling posture (GO:0050884)3.63351784
67regulation of postsynaptic membrane potential (GO:0060078)3.62972972
68C21-steroid hormone biosynthetic process (GO:0006700)3.62247867
69negative regulation of synaptic transmission, GABAergic (GO:0032229)3.60896340
70positive regulation of membrane potential (GO:0045838)3.57732280
71neurotransmitter transport (GO:0006836)3.57607121
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.57553416
73layer formation in cerebral cortex (GO:0021819)3.56383521
74negative regulation of catenin import into nucleus (GO:0035414)3.52879153
75axon extension involved in axon guidance (GO:0048846)3.50753330
76neuron projection extension involved in neuron projection guidance (GO:1902284)3.50753330
77dendritic spine morphogenesis (GO:0060997)3.50513378
78long-term synaptic potentiation (GO:0060291)3.49145675
79regulation of synaptic plasticity (GO:0048167)3.44848520
80ganglion development (GO:0061548)3.41422908
81neuron recognition (GO:0008038)3.40935971
82mating behavior (GO:0007617)3.40616241
83neuromuscular process controlling balance (GO:0050885)3.40536888
84regulation of cardioblast differentiation (GO:0051890)3.38398008
85cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.38056372
86cell differentiation in hindbrain (GO:0021533)3.38044030
87regulation of synaptic transmission, glutamatergic (GO:0051966)3.37912195
88regulation of synapse structural plasticity (GO:0051823)3.37845009
89cell-substrate junction assembly (GO:0007044)3.37824024
90cell adhesion mediated by integrin (GO:0033627)3.34055270
91cell communication by electrical coupling (GO:0010644)3.33672732
92proline transport (GO:0015824)3.33308787
93semaphorin-plexin signaling pathway (GO:0071526)3.33298145
94protein localization to endosome (GO:0036010)3.33276262
95innervation (GO:0060384)3.33172780
96postsynaptic membrane organization (GO:0001941)3.32675800
97L-serine transport (GO:0015825)3.32150054
98retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.31564482
99regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.30885385
100regulation of vesicle fusion (GO:0031338)3.30676841
101axonal fasciculation (GO:0007413)3.30583025
102membrane depolarization during action potential (GO:0086010)3.30299154
103regulation of neurotransmitter levels (GO:0001505)3.27902700
104prostanoid biosynthetic process (GO:0046457)3.27664411
105prostaglandin biosynthetic process (GO:0001516)3.27664411
106regulation of neurotransmitter secretion (GO:0046928)3.25821371
107hemoglobin metabolic process (GO:0020027)3.23391009
108behavioral fear response (GO:0001662)3.22329522
109behavioral defense response (GO:0002209)3.22329522
110membrane depolarization (GO:0051899)3.20692140
111presynaptic membrane organization (GO:0097090)3.19402386
112regulation of dendritic spine morphogenesis (GO:0061001)3.18755762
113membrane hyperpolarization (GO:0060081)3.18561521
114cell migration in hindbrain (GO:0021535)3.17551790
115axon extension (GO:0048675)3.17430752
116presynaptic membrane assembly (GO:0097105)3.16986609
117response to histamine (GO:0034776)3.16325892
118histone arginine methylation (GO:0034969)3.15762596
119vitamin A metabolic process (GO:0006776)3.15670054
120mitotic nuclear envelope reassembly (GO:0007084)3.14452013
121nuclear envelope reassembly (GO:0031468)3.14452013
122fear response (GO:0042596)3.12018332
123adult walking behavior (GO:0007628)3.11128212
124G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.11014652
125skin development (GO:0043588)3.10543781
126cochlea development (GO:0090102)3.10529937
127regulation of tight junction assembly (GO:2000810)3.08737928
128dendrite morphogenesis (GO:0048813)3.08616134
129positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.08233475
130neuromuscular process (GO:0050905)3.08089870
131synaptic transmission (GO:0007268)3.07304526
132long term synaptic depression (GO:0060292)3.03679184
133learning (GO:0007612)3.02866314
134cellular sodium ion homeostasis (GO:0006883)3.02853388
135synapse assembly (GO:0007416)3.02790694
136regulation of neurotransmitter transport (GO:0051588)3.02233913
137growth hormone secretion (GO:0030252)3.02120668
138pyrimidine nucleobase catabolic process (GO:0006208)3.01217537
139regulation of voltage-gated calcium channel activity (GO:1901385)2.99925369
140serine transport (GO:0032329)2.99870956
141auditory behavior (GO:0031223)2.98623137
142positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.97994961
143phagocytosis, recognition (GO:0006910)2.97601661
144planar cell polarity pathway involved in neural tube closure (GO:0090179)2.95773280
145positive regulation of synapse assembly (GO:0051965)2.95537291
146regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94886272
147respiratory system process (GO:0003016)2.93464808
148regulation of synaptic transmission (GO:0050804)2.93362900
149negative regulation of axon extension involved in axon guidance (GO:0048843)2.93355426
150type B pancreatic cell proliferation (GO:0044342)2.92355504
151C4-dicarboxylate transport (GO:0015740)2.91855786
152negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.90195294
153synapse organization (GO:0050808)2.90038805
154behavioral response to cocaine (GO:0048148)2.88907554
155neuromuscular synaptic transmission (GO:0007274)2.87718218
156neuronal ion channel clustering (GO:0045161)2.87614521
157stress fiber assembly (GO:0043149)2.86546425
158endothelial cell proliferation (GO:0001935)2.83703772
159barbed-end actin filament capping (GO:0051016)2.83496951
160regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.81530955
161neuron projection extension (GO:1990138)2.80092903
162regulation of transforming growth factor beta1 production (GO:0032908)2.79659959
163positive regulation of nitric-oxide synthase activity (GO:0051000)2.77520859
164protein maturation by protein folding (GO:0022417)2.76934574
165keratinocyte proliferation (GO:0043616)2.75376676
166negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.72547693
167endodermal cell differentiation (GO:0035987)2.71565673
168digestive tract morphogenesis (GO:0048546)2.70875355
169membrane raft organization (GO:0031579)2.70146358
170regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.70092247
171positive regulation of triglyceride biosynthetic process (GO:0010867)2.69124772
172cyclooxygenase pathway (GO:0019371)2.68318281
173positive regulation of axon extension (GO:0045773)2.66503964
174facial nerve structural organization (GO:0021612)2.65711124
175lipopolysaccharide biosynthetic process (GO:0009103)2.62496102
176mammary gland epithelial cell proliferation (GO:0033598)2.62290653
177collecting duct development (GO:0072044)2.61718189
178positive regulation of monooxygenase activity (GO:0032770)2.61562975
179dendritic spine organization (GO:0097061)2.59490889
180fibroblast migration (GO:0010761)2.59081688
181regulation of cholesterol biosynthetic process (GO:0045540)2.58263652
182atrioventricular valve morphogenesis (GO:0003181)2.56203978
183cholesterol biosynthetic process (GO:0006695)2.54206564
184positive regulation of blood vessel endothelial cell migration (GO:0043536)2.53115836
185skin morphogenesis (GO:0043589)2.49396460
186negative regulation of axon guidance (GO:1902668)2.44606509
187cellular copper ion homeostasis (GO:0006878)2.43691603
188positive regulation of male gonad development (GO:2000020)2.42977071
189ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.39876752
190progesterone metabolic process (GO:0042448)2.39483375
191regulation of axon extension involved in axon guidance (GO:0048841)2.39189897
192maintenance of protein localization in organelle (GO:0072595)2.37099818
193membrane budding (GO:0006900)2.36792607
194regulation of metalloenzyme activity (GO:0048552)2.36694096

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.24193154
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.09349966
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.21994432
4GBX2_23144817_ChIP-Seq_PC3_Human3.56759778
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.30257760
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.19944382
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15003329
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.12868121
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.99431717
10REST_21632747_ChIP-Seq_MESCs_Mouse2.88147923
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77220152
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77220152
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67572221
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.59036624
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58597412
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54447084
17DROSHA_22980978_ChIP-Seq_HELA_Human2.52151452
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50237516
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.46687301
20SRY_22984422_ChIP-ChIP_TESTIS_Rat2.46052173
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44476116
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44234825
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.40108825
24CLOCK_20551151_ChIP-Seq_293T_Human2.38448262
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.36643577
26ELK3_25401928_ChIP-Seq_HUVEC_Human2.29288366
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.28075617
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21947498
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.21559940
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20960443
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.19086721
32HIF1A_21447827_ChIP-Seq_MCF-7_Human2.18617131
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14102841
34UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human2.09818831
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.09561149
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05702194
37LXR_22292898_ChIP-Seq_THP-1_Human2.05676236
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03802032
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00710677
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97055963
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94718470
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91156066
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.81503703
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79321496
45ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.76281010
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73284957
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68050661
48RACK7_27058665_Chip-Seq_MCF-7_Human1.66947512
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.66676324
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62980822
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62851610
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62033365
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.61288706
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60959647
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57604504
56SMAD4_21799915_ChIP-Seq_A2780_Human1.51162740
57TAF15_26573619_Chip-Seq_HEK293_Human1.50880046
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49867173
59ZNF274_21170338_ChIP-Seq_K562_Hela1.49367920
60* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.49084379
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48022135
62AR_21572438_ChIP-Seq_LNCaP_Human1.47717358
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.47062995
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47018370
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46921520
66ATF3_27146783_Chip-Seq_COLON_Human1.45701978
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45050792
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45050792
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.43209629
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42268269
71RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41592527
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41255677
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39730220
74P63_26484246_Chip-Seq_KERATINOCYTES_Human1.37746204
75KDM2B_26808549_Chip-Seq_DND41_Human1.37133374
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.36038743
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.34590689
78TP53_22127205_ChIP-Seq_IMR90_Human1.34364090
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33306382
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.33190387
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32991907
82EGR1_19374776_ChIP-ChIP_THP-1_Human1.32878347
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31839994
84* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30602301
85* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30043427
86UBF1/2_26484160_Chip-Seq_HMECs_Human1.27812403
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27752281
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25937395
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.25411458
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25292421
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.23717618
92AR_19668381_ChIP-Seq_PC3_Human1.23484967
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22512706
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19513892
95ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19435432
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.18252617
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16871636
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15752533
99P300_19829295_ChIP-Seq_ESCs_Human1.15621712
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15491466
101SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.14595378
102AR_25329375_ChIP-Seq_VCAP_Human1.14578230
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.14301195
104SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14200487
105CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14112506
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13831810
107SA1_27219007_Chip-Seq_ERYTHROID_Human1.13749123
108SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13700759
109STAT3_23295773_ChIP-Seq_U87_Human1.12998116
110RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12251867
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11813508
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11134136
113EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10633797
114PIAS1_25552417_ChIP-Seq_VCAP_Human1.10130406
115CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09971338
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09818200
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09503110
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09444190
119STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08294685
120RNF2_27304074_Chip-Seq_NSC_Mouse1.08243682
121KDM2B_26808549_Chip-Seq_JURKAT_Human1.07896533
122* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07225680
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06278097
124NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06240490
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06062082
126ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05917310
127CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05187677
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04902853
129WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04106366
130FUS_26573619_Chip-Seq_HEK293_Human1.02939371
131* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01436487
132ARNT_22903824_ChIP-Seq_MCF-7_Human1.01222751
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01122469
134AHR_22903824_ChIP-Seq_MCF-7_Human1.00663723
135ZNF263_19887448_ChIP-Seq_K562_Human1.00373158
136YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00356434
137* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99485501
138GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98365444
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97996643
140TP63_22573176_ChIP-Seq_HFKS_Human0.97985483
141EGR1_19032775_ChIP-ChIP_M12_Human0.97296104
142TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97237189
143EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97000794
144TCF4_23295773_ChIP-Seq_U87_Human0.96430648
145KDM2B_26808549_Chip-Seq_K562_Human0.96373064
146CREB1_26743006_Chip-Seq_LNCaP_Human0.96018859
147ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95626315
148SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95470843
149* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95214676
150GATA2_21666600_ChIP-Seq_HMVEC_Human0.94666647
151ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94475339
152TP53_23651856_ChIP-Seq_MEFs_Mouse0.94195191
153TP53_20018659_ChIP-ChIP_R1E_Mouse0.94149690
154CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93444831
155MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93425829
156SMAD3_21741376_ChIP-Seq_ESCs_Human0.93347413
157SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91452630
158RUNX2_22187159_ChIP-Seq_PCA_Human0.91131116
159TET1_21490601_ChIP-Seq_MESCs_Mouse0.91113575
160VDR_21846776_ChIP-Seq_THP-1_Human0.90563729
161ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90453505
162TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.90429078
163VDR_22108803_ChIP-Seq_LS180_Human0.90014448
164TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89643945
165ELF1_20517297_ChIP-Seq_JURKAT_Human0.89173358
166CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87191198
167SMAD3_21741376_ChIP-Seq_HESCs_Human0.86823379
168OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86730738
169CTCF_27219007_Chip-Seq_Bcells_Human0.85394746
170TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85355254
171ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85176970
172SMAD4_21741376_ChIP-Seq_HESCs_Human0.84412092
173* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.82917698
174TP53_16413492_ChIP-PET_HCT116_Human0.82559120
175POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82046995
176TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82046995
177NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81920098
178STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.80221895

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.88047979
2MP0008004_abnormal_stomach_pH5.67897414
3MP0003880_abnormal_central_pattern4.54760916
4MP0003635_abnormal_synaptic_transmissio4.00188685
5MP0009046_muscle_twitch3.55484124
6MP0004270_analgesia3.49971337
7MP0009745_abnormal_behavioral_response3.25756763
8MP0002064_seizures3.15376407
9MP0002063_abnormal_learning/memory/cond3.10758813
10MP0001968_abnormal_touch/_nociception2.81273467
11MP0000579_abnormal_nail_morphology2.75941626
12MP0002272_abnormal_nervous_system2.75024285
13MP0002572_abnormal_emotion/affect_behav2.67817364
14MP0005423_abnormal_somatic_nervous2.59095413
15MP0003705_abnormal_hypodermis_morpholog2.55146797
16MP0002734_abnormal_mechanical_nocicepti2.54072611
17MP0003566_abnormal_cell_adhesion2.52902795
18MP0008260_abnormal_autophagy2.52874745
19MP0001486_abnormal_startle_reflex2.43971353
20MP0001440_abnormal_grooming_behavior2.38994614
21MP0002736_abnormal_nociception_after2.35034567
22MP0004272_abnormal_basement_membrane2.33981369
23MP0002735_abnormal_chemical_nociception2.29170738
24MP0001501_abnormal_sleep_pattern2.26533543
25MP0000762_abnormal_tongue_morphology2.24460162
26MP0002332_abnormal_exercise_endurance2.16009862
27MP0002184_abnormal_innervation2.11125559
28MP0008569_lethality_at_weaning2.07150443
29MP0002067_abnormal_sensory_capabilities2.06832722
30MP0003329_amyloid_beta_deposits2.01307123
31MP0008438_abnormal_cutaneous_collagen1.99444727
32MP0002733_abnormal_thermal_nociception1.93775237
33MP0005670_abnormal_white_adipose1.86737214
34MP0001984_abnormal_olfaction1.83855617
35MP0001970_abnormal_pain_threshold1.83795075
36MP0000778_abnormal_nervous_system1.83794972
37MP0003011_delayed_dark_adaptation1.80409880
38MP0004858_abnormal_nervous_system1.77487732
39MP0004885_abnormal_endolymph1.75076580
40MP0001849_ear_inflammation1.73780613
41MP0002822_catalepsy1.69870341
42MP0002557_abnormal_social/conspecific_i1.68181394
43MP0000955_abnormal_spinal_cord1.66758113
44MP0004142_abnormal_muscle_tone1.65337899
45MP0002060_abnormal_skin_morphology1.63314715
46MP0005257_abnormal_intraocular_pressure1.63269807
47MP0004145_abnormal_muscle_electrophysio1.61873651
48MP0005023_abnormal_wound_healing1.61259834
49MP0005386_behavior/neurological_phenoty1.53944733
50MP0004924_abnormal_behavior1.53944733
51MP0004811_abnormal_neuron_physiology1.53303950
52MP0002877_abnormal_melanocyte_morpholog1.52138755
53MP0002882_abnormal_neuron_morphology1.51165251
54MP0005501_abnormal_skin_physiology1.50103694
55MP0002796_impaired_skin_barrier1.49574711
56MP0000639_abnormal_adrenal_gland1.48337879
57MP0001188_hyperpigmentation1.47218742
58MP0000750_abnormal_muscle_regeneration1.44698978
59MP0006276_abnormal_autonomic_nervous1.44424991
60MP0002066_abnormal_motor_capabilities/c1.43536624
61MP0010030_abnormal_orbit_morphology1.42489504
62MP0003879_abnormal_hair_cell1.40526353
63MP0009780_abnormal_chondrocyte_physiolo1.40010112
64MP0008789_abnormal_olfactory_epithelium1.39677444
65MP0002909_abnormal_adrenal_gland1.38913943
66MP0001502_abnormal_circadian_rhythm1.37826666
67MP0003279_aneurysm1.36489910
68MP0005551_abnormal_eye_electrophysiolog1.35788808
69MP0005646_abnormal_pituitary_gland1.29153470
70MP0000467_abnormal_esophagus_morphology1.28498774
71MP0003191_abnormal_cellular_cholesterol1.27187772
72MP0003787_abnormal_imprinting1.27162200
73MP0004510_myositis1.26064766
74MP0002254_reproductive_system_inflammat1.23815994
75MP0001216_abnormal_epidermal_layer1.21566889
76MP0002152_abnormal_brain_morphology1.21509613
77MP0005275_abnormal_skin_tensile1.20410321
78MP0003385_abnormal_body_wall1.20039218
79MP0004233_abnormal_muscle_weight1.19644605
80MP0010771_integument_phenotype1.19299149
81MP0003122_maternal_imprinting1.18582631
82MP0001529_abnormal_vocalization1.18392140
83MP0003453_abnormal_keratinocyte_physiol1.16543784
84MP0003633_abnormal_nervous_system1.15086736
85MP0003632_abnormal_nervous_system1.13549972
86MP0003631_nervous_system_phenotype1.12925740
87MP0003283_abnormal_digestive_organ1.12378127
88MP0000462_abnormal_digestive_system1.12177583
89MP0003091_abnormal_cell_migration1.10538934
90MP0001905_abnormal_dopamine_level1.09075473
91MP0004742_abnormal_vestibular_system1.08445908
92MP0002229_neurodegeneration1.07699567
93MP0009250_abnormal_appendicular_skeleto1.06644112
94MP0005508_abnormal_skeleton_morphology1.06327296
95MP0003300_gastrointestinal_ulcer1.03584309
96MP0002653_abnormal_ependyma_morphology1.02337065
97MP0000751_myopathy1.01212986
98MP0002752_abnormal_somatic_nervous0.97055613
99MP0003172_abnormal_lysosome_physiology0.95060762
100MP0003634_abnormal_glial_cell0.94938586
101MP0001485_abnormal_pinna_reflex0.94601389
102MP0006072_abnormal_retinal_apoptosis0.94482619
103MP0002896_abnormal_bone_mineralization0.92678120
104MP0005164_abnormal_response_to0.90889841
105MP0000678_abnormal_parathyroid_gland0.90432782
106MP0003183_abnormal_peptide_metabolism0.90297011
107MP0005645_abnormal_hypothalamus_physiol0.88774309
108MP0008872_abnormal_physiological_respon0.88431849
109MP0001963_abnormal_hearing_physiology0.88159353
110MP0001661_extended_life_span0.87381208
111MP0010368_abnormal_lymphatic_system0.86572644
112MP0002069_abnormal_eating/drinking_beha0.85712776
113MP0004883_abnormal_blood_vessel0.85525550
114MP0000534_abnormal_ureter_morphology0.85366627
115MP0005394_taste/olfaction_phenotype0.84220503
116MP0005499_abnormal_olfactory_system0.84220503
117MP0005197_abnormal_uvea_morphology0.83730263
118MP0009840_abnormal_foam_cell0.83522122
119MP0009053_abnormal_anal_canal0.82061230
120MP0002638_abnormal_pupillary_reflex0.78842740
121MP0003786_premature_aging0.77482387
122MP0005623_abnormal_meninges_morphology0.76826103
123MP0003755_abnormal_palate_morphology0.76652795
124MP0000631_abnormal_neuroendocrine_gland0.76109264
125MP0010386_abnormal_urinary_bladder0.76034497
126MP0001299_abnormal_eye_distance/0.75332399
127MP0002089_abnormal_postnatal_growth/wei0.75175201
128MP0002233_abnormal_nose_morphology0.74659108
129MP0003861_abnormal_nervous_system0.74358199
130MP0004215_abnormal_myocardial_fiber0.73720840
131MP0003690_abnormal_glial_cell0.73712969
132MP0000920_abnormal_myelination0.73597829
133MP0003137_abnormal_impulse_conducting0.73310166
134MP0003315_abnormal_perineum_morphology0.73297934
135MP0004947_skin_inflammation0.72929511
136MP0004085_abnormal_heartbeat0.72897882
137MP0000604_amyloidosis0.72122209
138MP0001177_atelectasis0.71836870
139MP0002837_dystrophic_cardiac_calcinosis0.71266257
140MP0002090_abnormal_vision0.70789342
141MP0003828_pulmonary_edema0.69236690
142MP0001542_abnormal_bone_strength0.68747637
143MP0000733_abnormal_muscle_development0.68742169
144MP0003121_genomic_imprinting0.68294647
145MP0008961_abnormal_basal_metabolism0.67186073
146MP0004133_heterotaxia0.67079789
147MP0005375_adipose_tissue_phenotype0.65829825
148MP0005187_abnormal_penis_morphology0.65722430
149MP0003075_altered_response_to0.65131743
150MP0002269_muscular_atrophy0.65085980
151MP0006292_abnormal_olfactory_placode0.64725506
152MP0001340_abnormal_eyelid_morphology0.64645696
153MP0005193_abnormal_anterior_eye0.63543875
154MP0004185_abnormal_adipocyte_glucose0.63488285
155MP0005409_darkened_coat_color0.63276482
156MP0005076_abnormal_cell_differentiation0.62850814
157MP0005171_absent_coat_pigmentation0.60917446
158MP0000026_abnormal_inner_ear0.60653665
159MP0010769_abnormal_survival0.60170818
160MP0008874_decreased_physiological_sensi0.58631605
161MP0002234_abnormal_pharynx_morphology0.58187247
162MP0010768_mortality/aging0.57597286
163MP0002082_postnatal_lethality0.57500318
164MP0010770_preweaning_lethality0.57500318
165MP0001943_abnormal_respiration0.57235839
166MP0004484_altered_response_of0.56577031
167MP0004043_abnormal_pH_regulation0.56523687
168MP0000013_abnormal_adipose_tissue0.56475545
169MP0005253_abnormal_eye_physiology0.55729578

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.17381715
2Myokymia (HP:0002411)5.83593124
3Focal seizures (HP:0007359)5.56197931
4Visual hallucinations (HP:0002367)5.03854617
5Progressive cerebellar ataxia (HP:0002073)4.94795820
6Epileptic encephalopathy (HP:0200134)4.86129548
7Atonic seizures (HP:0010819)4.81227474
8Febrile seizures (HP:0002373)4.43846815
9Anomalous pulmonary venous return (HP:0010772)4.37308371
10Atrophic scars (HP:0001075)4.24181847
11Fragile nails (HP:0001808)4.19317996
12Action tremor (HP:0002345)4.18524018
13Absence seizures (HP:0002121)4.17360051
14Dialeptic seizures (HP:0011146)3.89086904
15Milia (HP:0001056)3.84066848
16Abnormality of the pulmonary veins (HP:0011718)3.78226676
17Gaze-evoked nystagmus (HP:0000640)3.70272956
18Generalized tonic-clonic seizures (HP:0002069)3.56587172
19Short nail (HP:0001799)3.54309422
20Dysdiadochokinesis (HP:0002075)3.48297780
21Thick nail (HP:0001805)3.42987320
22Broad-based gait (HP:0002136)3.34958391
23Premature rupture of membranes (HP:0001788)3.29514530
24Large earlobe (HP:0009748)3.25656791
25Acanthosis nigricans (HP:0000956)3.16843138
26Onycholysis (HP:0001806)3.10476416
27Dysmetria (HP:0001310)3.08823782
28Relative macrocephaly (HP:0004482)3.08381662
29Hemiparesis (HP:0001269)3.08309577
30Cervical subluxation (HP:0003308)3.04158836
31Scanning speech (HP:0002168)3.01548625
32Genetic anticipation (HP:0003743)3.00856919
33Truncal ataxia (HP:0002078)3.00310763
34Supranuclear gaze palsy (HP:0000605)2.95185111
35Abnormality of the lower motor neuron (HP:0002366)2.93929956
36Plantar hyperkeratosis (HP:0007556)2.86722668
37Impaired smooth pursuit (HP:0007772)2.84538334
38Hand muscle atrophy (HP:0009130)2.81959235
39Abnormality of binocular vision (HP:0011514)2.81337591
40Diplopia (HP:0000651)2.81337591
41Distal upper limb amyotrophy (HP:0007149)2.78307892
42Upper limb amyotrophy (HP:0009129)2.78307892
43Fetal akinesia sequence (HP:0001989)2.77723456
44Entropion (HP:0000621)2.77343411
45Abnormal eating behavior (HP:0100738)2.77236952
46Rhizomelia (HP:0008905)2.77215967
47Depression (HP:0000716)2.75032277
48Hyperventilation (HP:0002883)2.74833157
49Nail dystrophy (HP:0008404)2.73603151
50Neonatal respiratory distress (HP:0002643)2.71232961
51Abnormal gallbladder physiology (HP:0012438)2.70687173
52Cholecystitis (HP:0001082)2.70687173
53Impaired vibration sensation in the lower limbs (HP:0002166)2.70553175
54Alopecia of scalp (HP:0002293)2.70354904
55Ankle clonus (HP:0011448)2.67682513
56Abnormality of nail color (HP:0100643)2.65658270
57Amblyopia (HP:0000646)2.63012252
58Small epiphyses (HP:0010585)2.62715303
59Poor eye contact (HP:0000817)2.61570058
60Abnormality of ocular smooth pursuit (HP:0000617)2.58900236
61Natal tooth (HP:0000695)2.55388971
62Intention tremor (HP:0002080)2.55125843
63Hemiplegia (HP:0002301)2.54209826
64Epileptiform EEG discharges (HP:0011182)2.53951942
65Mutism (HP:0002300)2.53298851
66Distal lower limb amyotrophy (HP:0008944)2.52515310
67Dysmetric saccades (HP:0000641)2.52164108
68Abnormality of the alveolar ridges (HP:0006477)2.51647792
69Abnormal social behavior (HP:0012433)2.49467094
70Impaired social interactions (HP:0000735)2.49467094
71Anxiety (HP:0000739)2.48899312
72Ulnar bowing (HP:0003031)2.46248712
73Status epilepticus (HP:0002133)2.45868380
74Postural instability (HP:0002172)2.43199129
75Urinary bladder sphincter dysfunction (HP:0002839)2.41658224
76Excessive salivation (HP:0003781)2.39473767
77Drooling (HP:0002307)2.39473767
78Protrusio acetabuli (HP:0003179)2.38482673
79Fragile skin (HP:0001030)2.35774652
80EEG with generalized epileptiform discharges (HP:0011198)2.35625301
81Upper limb muscle weakness (HP:0003484)2.35599467
82Spastic gait (HP:0002064)2.34794506
83Delayed gross motor development (HP:0002194)2.33952608
84Difficulty climbing stairs (HP:0003551)2.30574353
85Cerebral inclusion bodies (HP:0100314)2.29422364
86Neurofibrillary tangles (HP:0002185)2.27619815
87Deviation of the thumb (HP:0009603)2.27332998
88Abnormality of the aortic arch (HP:0012303)2.24534936
89Abnormality of the labia minora (HP:0012880)2.24100095
90Absent speech (HP:0001344)2.23161835
91Abnormality of the corticospinal tract (HP:0002492)2.22346193
92Spinal rigidity (HP:0003306)2.21201782
93Abnormality of carpal bone ossification (HP:0006257)2.20220837
94Pterygium (HP:0001059)2.19543374
95Hypsarrhythmia (HP:0002521)2.17151609
96Vertebral clefting (HP:0008428)2.16545579
97Stereotypic behavior (HP:0000733)2.15826990
98Polyphagia (HP:0002591)2.15242419
99Abnormality of the fetal cardiovascular system (HP:0010948)2.14712518
100Abnormal umbilical cord blood vessels (HP:0011403)2.14712518
101Single umbilical artery (HP:0001195)2.14712518
102Distal lower limb muscle weakness (HP:0009053)2.13455669
103Vertebral arch anomaly (HP:0008438)2.13132908
104Annular pancreas (HP:0001734)2.12659084
105Abnormality of dentin (HP:0010299)2.11790522
106Long palpebral fissure (HP:0000637)2.11161428
107Hypoplasia of the capital femoral epiphysis (HP:0003090)2.09993828
108Delusions (HP:0000746)2.09752644
109Mitral stenosis (HP:0001718)2.09066946
110Bradykinesia (HP:0002067)2.08840349
111Flattened epiphyses (HP:0003071)2.07703325
112Bowed forearm bones (HP:0003956)2.07195979
113Bowing of the arm (HP:0006488)2.07195979
114Megalencephaly (HP:0001355)2.06913952
115Ventricular fibrillation (HP:0001663)2.06862635
116Aplasia involving bones of the extremities (HP:0009825)2.06188515
117Aplasia involving bones of the upper limbs (HP:0009823)2.06188515
118Aplasia of the phalanges of the hand (HP:0009802)2.06188515
119Achilles tendon contracture (HP:0001771)2.04831289
120Urinary urgency (HP:0000012)2.03814739
121Abnormality of the umbilical cord (HP:0010881)2.03643232
122Incomplete penetrance (HP:0003829)2.02038846
123* Hypoplasia of dental enamel (HP:0006297)2.01847979
124Right ventricular cardiomyopathy (HP:0011663)2.01403107
125Hyperacusis (HP:0010780)2.00902832
126Growth hormone excess (HP:0000845)2.00152249
127Hydroureter (HP:0000072)1.96984624
128Proximal placement of thumb (HP:0009623)1.96906210
129Broad face (HP:0000283)1.96685530
130Insulin resistance (HP:0000855)1.96255739
131Abnormal ossification of hand bones (HP:0005921)1.93194494
132Torticollis (HP:0000473)1.92709879
133Progressive inability to walk (HP:0002505)1.92470445
134Specific learning disability (HP:0001328)1.92385774
135Akinesia (HP:0002304)1.91866665
136Insomnia (HP:0100785)1.91181411
137Pheochromocytoma (HP:0002666)1.90977603
138Focal dystonia (HP:0004373)1.89800775
139Ankyloglossia (HP:0010296)1.89506516
140Popliteal pterygium (HP:0009756)1.88234055
141Mitral regurgitation (HP:0001653)1.87745441
142Cupped ear (HP:0000378)1.87616203
143Lower limb muscle weakness (HP:0007340)1.86831250
144Abnormality of the distal phalanges of the toes (HP:0010182)1.86473350
145Palmoplantar hyperkeratosis (HP:0000972)1.85900623
146Gait ataxia (HP:0002066)1.83741788
147Abnormal blistering of the skin (HP:0008066)1.83151062
148Abnormalities of placenta or umbilical cord (HP:0001194)1.83005922
149Gait imbalance (HP:0002141)1.82843886
150Impaired vibratory sensation (HP:0002495)1.82581708
151Double outlet right ventricle (HP:0001719)1.82265761
152Congenital malformation of the right heart (HP:0011723)1.82265761
153Palmar hyperkeratosis (HP:0010765)1.81935142
154Generalized myoclonic seizures (HP:0002123)1.81469677
155Precocious puberty (HP:0000826)1.80574096
156Renal salt wasting (HP:0000127)1.79903999
157Poikiloderma (HP:0001029)1.79863097
158Termporal pattern (HP:0011008)1.79654765
159Insidious onset (HP:0003587)1.79654765
160Tetraplegia (HP:0002445)1.79538650
161Neuronal loss in central nervous system (HP:0002529)1.78510101
162Lower limb amyotrophy (HP:0007210)1.77330774
163Limb ataxia (HP:0002070)1.77048468
164Thickened helices (HP:0000391)1.76644679
165* Aplasia/Hypoplasia of the clavicles (HP:0006710)1.75845344
166* Supernumerary nipples (HP:0002558)1.75738530
167Partial agenesis of the corpus callosum (HP:0001338)1.74429392
168Psychosis (HP:0000709)1.73633667
169Limb dystonia (HP:0002451)1.73339950
170Retinal dysplasia (HP:0007973)1.73177109
171Trismus (HP:0000211)1.71964649
172Abnormality of oral frenula (HP:0000190)1.70802579
173Horizontal nystagmus (HP:0000666)1.70543441
174Postural tremor (HP:0002174)1.69686163
175Failure to thrive in infancy (HP:0001531)1.69184694
176Ridged nail (HP:0001807)1.68242099
177Clonus (HP:0002169)1.68136411
178Axonal loss (HP:0003447)1.68128503
179Limb-girdle muscle atrophy (HP:0003797)1.67723394
180Abnormality of saccadic eye movements (HP:0000570)1.65819165
181Deep palmar crease (HP:0006191)1.64093169
182Wrist flexion contracture (HP:0001239)1.63812206
183Spondylolisthesis (HP:0003302)1.63186760
184Abnormal pancreas size (HP:0012094)1.61891381
185Craniofacial dystonia (HP:0012179)1.61804786
186Esotropia (HP:0000565)1.60828653
187Morphological abnormality of the pyramidal tract (HP:0002062)1.60808903
188Rigidity (HP:0002063)1.60445506
189Tibial bowing (HP:0002982)1.60376325
190Poor suck (HP:0002033)1.60109277
191Agitation (HP:0000713)1.59910238
192Sleep apnea (HP:0010535)1.59465987
193Syringomyelia (HP:0003396)1.58950813
194Spinal cord lesions (HP:0100561)1.58950813
195* Short clavicles (HP:0000894)1.58151596
196Abnormality of the Achilles tendon (HP:0005109)1.57405686
197Centrally nucleated skeletal muscle fibers (HP:0003687)1.55405707

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.85679481
2TAOK24.16655399
3EPHA44.05911934
4MAP3K93.70498269
5MAP3K42.90109039
6TESK12.88062538
7PIM22.62804330
8LIMK12.47351452
9MINK12.42830610
10MARK12.36503509
11CASK2.35522913
12EPHA22.32656450
13DAPK22.26357064
14MAP2K72.14614394
15PAK62.10832009
16EPHB22.10457306
17PNCK2.10204003
18TNIK2.06624295
19CDK191.95085594
20PRPF4B1.92163758
21NTRK21.89561146
22KSR21.87021782
23MOS1.78651224
24SIK11.76630745
25KSR11.68134491
26STK381.65747140
27PTK21.63276480
28ARAF1.61289732
29MAP2K41.57505204
30PLK21.53723117
31DAPK11.45687150
32EPHB11.44983858
33BCKDK1.41105060
34CDK51.40754844
35IRAK31.36850819
36CAMKK21.35521810
37PRKCG1.35168473
38GRK51.34098370
39TESK21.33728607
40CAMKK11.31900922
41OXSR11.30460002
42MST1R1.29617532
43MAP3K31.28644471
44NTRK11.28456681
45TYRO31.28045402
46MAP3K121.27512511
47AKT31.27132688
48MAPK131.26554366
49ERN11.24206702
50NME21.20824546
51RIPK41.18858793
52PRKD31.17903150
53PHKG21.14318882
54PHKG11.14318882
55MAP3K111.11367525
56MET1.09891794
57CAMK2B1.09151648
58MAP3K131.08245082
59TTN1.07763094
60CAMK2A1.06509251
61PRKD21.06460995
62TRIB31.05941354
63UHMK11.05890360
64CDK181.05036381
65CDK151.02800672
66CDK141.00311778
67DDR20.97156668
68SGK2230.95402075
69SGK4940.95402075
70GRK70.94545826
71BCR0.91688515
72CDK11A0.90318135
73FLT30.90130825
74FER0.87820186
75MAP3K20.87707090
76PAK40.86393791
77PKN20.85609368
78ABL20.85603881
79CAMK10.85285916
80DYRK1A0.85265347
81PAK30.84862178
82MAP3K50.84031194
83PINK10.83399535
84LATS20.81574498
85DYRK20.80858919
86PDGFRA0.80418020
87PTK2B0.78704602
88DMPK0.76275207
89ALK0.75991517
90WNK10.74968742
91STK100.72200713
92CAMK2D0.72025736
93CAMK2G0.71843140
94NME10.70540176
95FES0.69987154
96ERBB40.69187184
97BRAF0.68801694
98CSNK1A1L0.68248129
99RAF10.67569717
100NEK10.67150784
101SIK20.67131433
102NEK60.66559291
103CSNK1G20.66466318
104TSSK60.65354570
105STK110.65023003
106LMTK20.64187286
107MARK20.64026714
108CSNK1G30.64022324
109ICK0.63916797
110SGK20.62954121
111ROCK20.61344329
112SGK10.59368264
113CDC42BPA0.58868333
114DYRK1B0.57243673
115RPS6KA20.56741829
116RPS6KA30.52603439
117PRKCE0.51665580
118FGR0.50964391
119ILK0.50883056
120MTOR0.50217592
121CDK80.50189320
122BMPR20.49533546
123RET0.49271290
124MAP2K10.48021794
125WNK30.47550669
126MAPK100.46302082
127SGK30.46247041
128CAMK40.45274548
129PRKCH0.44904806
130PDPK10.44255580
131TAOK10.44097761
132STK390.44029106
133IRAK20.43768136
134SIK30.43353057
135CSNK1E0.41942304
136PAK10.41291488
137RIPK10.38980844
138PDK10.38843210
139AURKA0.37357799
140CCNB10.37355699
141TGFBR20.35635227
142PRKACA0.35610627
143CAMK1G0.35301948
144PRKG10.35191352
145DAPK30.34679291
146ROCK10.33771284
147PRKCD0.32061646
148EIF2AK30.30224928
149PTK60.29505670
150PRKCI0.28952349
151CSNK1G10.28690703
152STK160.27998217
153MAP3K80.27637687
154ZAP700.26277462

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.48844277
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.13623348
3Steroid biosynthesis_Homo sapiens_hsa001004.13467068
4Synaptic vesicle cycle_Homo sapiens_hsa047213.46433586
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.95187526
6GABAergic synapse_Homo sapiens_hsa047272.88175560
7Circadian entrainment_Homo sapiens_hsa047132.82941373
8Glutamatergic synapse_Homo sapiens_hsa047242.76051505
9Long-term potentiation_Homo sapiens_hsa047202.75772682
10Morphine addiction_Homo sapiens_hsa050322.54079499
11Amphetamine addiction_Homo sapiens_hsa050312.51778036
12Olfactory transduction_Homo sapiens_hsa047402.44266119
13Salivary secretion_Homo sapiens_hsa049702.28735484
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.15469335
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.12424443
16Dopaminergic synapse_Homo sapiens_hsa047282.10084990
17Taste transduction_Homo sapiens_hsa047422.08751492
18Insulin secretion_Homo sapiens_hsa049112.05537987
19Long-term depression_Homo sapiens_hsa047301.98119338
20Ovarian steroidogenesis_Homo sapiens_hsa049131.84514492
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83766863
22Gastric acid secretion_Homo sapiens_hsa049711.75488102
23Cholinergic synapse_Homo sapiens_hsa047251.75104110
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.72982289
25Galactose metabolism_Homo sapiens_hsa000521.72819671
26Collecting duct acid secretion_Homo sapiens_hsa049661.71064045
27Serotonergic synapse_Homo sapiens_hsa047261.66583863
28Calcium signaling pathway_Homo sapiens_hsa040201.66578656
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.65847729
30Oxytocin signaling pathway_Homo sapiens_hsa049211.61040723
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60602482
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.58416936
33Renin secretion_Homo sapiens_hsa049241.55438732
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48210483
35Cocaine addiction_Homo sapiens_hsa050301.47898619
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41026025
37Vitamin B6 metabolism_Homo sapiens_hsa007501.39792280
38ECM-receptor interaction_Homo sapiens_hsa045121.37984406
39Gap junction_Homo sapiens_hsa045401.37715095
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36781036
41GnRH signaling pathway_Homo sapiens_hsa049121.33586931
42Shigellosis_Homo sapiens_hsa051311.32419916
43Focal adhesion_Homo sapiens_hsa045101.28309391
44cAMP signaling pathway_Homo sapiens_hsa040241.23807488
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22858629
46Cardiac muscle contraction_Homo sapiens_hsa042601.22557801
47Salmonella infection_Homo sapiens_hsa051321.22055420
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18078624
49Proteoglycans in cancer_Homo sapiens_hsa052051.17582288
50Pentose phosphate pathway_Homo sapiens_hsa000301.16301138
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16252820
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14124657
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13806596
54Estrogen signaling pathway_Homo sapiens_hsa049151.13516033
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11247607
56Axon guidance_Homo sapiens_hsa043601.10619504
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10039628
58Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09101298
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07082362
60Vibrio cholerae infection_Homo sapiens_hsa051101.06799227
61Biosynthesis of amino acids_Homo sapiens_hsa012301.06511838
62Phototransduction_Homo sapiens_hsa047441.06112519
63Pancreatic secretion_Homo sapiens_hsa049721.04803860
64Other glycan degradation_Homo sapiens_hsa005111.04043677
65Type II diabetes mellitus_Homo sapiens_hsa049301.02975952
66Melanogenesis_Homo sapiens_hsa049161.02885134
67Notch signaling pathway_Homo sapiens_hsa043301.02422955
68cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01930689
69Hippo signaling pathway_Homo sapiens_hsa043901.00974582
70Oocyte meiosis_Homo sapiens_hsa041141.00852593
71Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00615371
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98002796
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96841356
74Adherens junction_Homo sapiens_hsa045200.94359795
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.92026209
76Amoebiasis_Homo sapiens_hsa051460.89955244
77ErbB signaling pathway_Homo sapiens_hsa040120.85887204
78Fructose and mannose metabolism_Homo sapiens_hsa000510.83737807
79Glioma_Homo sapiens_hsa052140.83648787
80Thyroid hormone synthesis_Homo sapiens_hsa049180.82843738
81Endometrial cancer_Homo sapiens_hsa052130.81407026
82Circadian rhythm_Homo sapiens_hsa047100.80564244
83Dilated cardiomyopathy_Homo sapiens_hsa054140.79977520
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78631724
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.78391450
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76829825
87Lysosome_Homo sapiens_hsa041420.75759843
88Chronic myeloid leukemia_Homo sapiens_hsa052200.72112618
89Phagosome_Homo sapiens_hsa041450.70358674
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68112262
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68042799
92Bladder cancer_Homo sapiens_hsa052190.67562475
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66542093
94Choline metabolism in cancer_Homo sapiens_hsa052310.66221968
95TGF-beta signaling pathway_Homo sapiens_hsa043500.63393700
96Alzheimers disease_Homo sapiens_hsa050100.62594520
97Dorso-ventral axis formation_Homo sapiens_hsa043200.61267840
98HIF-1 signaling pathway_Homo sapiens_hsa040660.60176031
99MAPK signaling pathway_Homo sapiens_hsa040100.59355889
100Apoptosis_Homo sapiens_hsa042100.59012574
101Small cell lung cancer_Homo sapiens_hsa052220.58806462
102Sulfur relay system_Homo sapiens_hsa041220.58339328
103TNF signaling pathway_Homo sapiens_hsa046680.57713474
104Thyroid cancer_Homo sapiens_hsa052160.56057855
105Carbon metabolism_Homo sapiens_hsa012000.55106845
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52587374
107Oxidative phosphorylation_Homo sapiens_hsa001900.51633201
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51453798
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50960102
110Pancreatic cancer_Homo sapiens_hsa052120.49999125
111Inositol phosphate metabolism_Homo sapiens_hsa005620.49873271
112Glucagon signaling pathway_Homo sapiens_hsa049220.48731721
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48163814
114Hepatitis C_Homo sapiens_hsa051600.47538786
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47240431
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46936113
117Nitrogen metabolism_Homo sapiens_hsa009100.46894960
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46700169
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46418674
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45728220
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45348588
122Prolactin signaling pathway_Homo sapiens_hsa049170.44469260
123Alcoholism_Homo sapiens_hsa050340.44328130
124Melanoma_Homo sapiens_hsa052180.44243767
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43952909
126Bile secretion_Homo sapiens_hsa049760.43771439
127Ras signaling pathway_Homo sapiens_hsa040140.42832519
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42555332
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41944066
130* Wnt signaling pathway_Homo sapiens_hsa043100.41677340
131Rap1 signaling pathway_Homo sapiens_hsa040150.41204952
132Hedgehog signaling pathway_Homo sapiens_hsa043400.40766424
133mTOR signaling pathway_Homo sapiens_hsa041500.39701785
134VEGF signaling pathway_Homo sapiens_hsa043700.38776553
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.38375853
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38037303
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37252380
138Endocytosis_Homo sapiens_hsa041440.35515565
139Renal cell carcinoma_Homo sapiens_hsa052110.35155773
140Fatty acid biosynthesis_Homo sapiens_hsa000610.33512980
141Prion diseases_Homo sapiens_hsa050200.33508914
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.33482860
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32485783
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.30207193
145Tight junction_Homo sapiens_hsa045300.29015515
146Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28249403
147Mineral absorption_Homo sapiens_hsa049780.26620896
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26011261
149Huntingtons disease_Homo sapiens_hsa050160.25954296
150Parkinsons disease_Homo sapiens_hsa050120.25778795
151Central carbon metabolism in cancer_Homo sapiens_hsa052300.21636201
152Insulin signaling pathway_Homo sapiens_hsa049100.21265353

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