Rank | Gene Set | Z-score |
---|---|---|
1 | ventricular trabecula myocardium morphogenesis (GO:0003222) | 7.55425421 |
2 | DNA damage response, detection of DNA damage (GO:0042769) | 7.50134587 |
3 | negative regulation of cardiac muscle cell apoptotic process (GO:0010667) | 6.67918596 |
4 | heart trabecula morphogenesis (GO:0061384) | 6.03670452 |
5 | DNA replication checkpoint (GO:0000076) | 5.89664901 |
6 | artery development (GO:0060840) | 5.50580033 |
7 | positive regulation of response to oxidative stress (GO:1902884) | 5.24192412 |
8 | positive regulation of cellular response to oxidative stress (GO:1900409) | 5.24192412 |
9 | intra-S DNA damage checkpoint (GO:0031573) | 5.06643135 |
10 | trabecula morphogenesis (GO:0061383) | 4.84672334 |
11 | lymphangiogenesis (GO:0001946) | 4.64414643 |
12 | embryonic foregut morphogenesis (GO:0048617) | 4.54744394 |
13 | nuclear pore complex assembly (GO:0051292) | 4.50422997 |
14 | negative regulation of striated muscle cell apoptotic process (GO:0010664) | 4.47180214 |
15 | interkinetic nuclear migration (GO:0022027) | 4.38468294 |
16 | response to ischemia (GO:0002931) | 4.36026661 |
17 | ventricular cardiac muscle cell development (GO:0055015) | 4.32702266 |
18 | CENP-A containing nucleosome assembly (GO:0034080) | 4.28724016 |
19 | single strand break repair (GO:0000012) | 4.26883571 |
20 | cell adhesion mediated by integrin (GO:0033627) | 4.17902209 |
21 | histone-serine phosphorylation (GO:0035404) | 4.14423825 |
22 | nuclear pore organization (GO:0006999) | 4.08294129 |
23 | chromatin remodeling at centromere (GO:0031055) | 4.04067826 |
24 | regulation of cardiac muscle cell apoptotic process (GO:0010665) | 3.97580206 |
25 | gastrulation with mouth forming second (GO:0001702) | 3.96335221 |
26 | protein localization to lysosome (GO:0061462) | 3.83833357 |
27 | protein localization to vacuole (GO:0072665) | 3.83833357 |
28 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.80325818 |
29 | organ growth (GO:0035265) | 3.74485000 |
30 | protein localization to kinetochore (GO:0034501) | 3.67127627 |
31 | cardiac right ventricle morphogenesis (GO:0003215) | 3.65202581 |
32 | chromosome condensation (GO:0030261) | 3.65176854 |
33 | replication fork processing (GO:0031297) | 3.58549921 |
34 | activin receptor signaling pathway (GO:0032924) | 3.57276111 |
35 | endothelial cell differentiation (GO:0045446) | 3.56529719 |
36 | kinetochore organization (GO:0051383) | 3.49603536 |
37 | cullin deneddylation (GO:0010388) | 3.45014873 |
38 | histone exchange (GO:0043486) | 3.44621063 |
39 | maturation of 5.8S rRNA (GO:0000460) | 3.41368806 |
40 | positive regulation of histone H3-K4 methylation (GO:0051571) | 3.40473345 |
41 | brain morphogenesis (GO:0048854) | 3.39107095 |
42 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.35653852 |
43 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.35653852 |
44 | NADH dehydrogenase complex assembly (GO:0010257) | 3.35653852 |
45 | heterochromatin organization (GO:0070828) | 3.28678706 |
46 | resolution of meiotic recombination intermediates (GO:0000712) | 3.24506989 |
47 | renal system development (GO:0072001) | 3.22107575 |
48 | pore complex assembly (GO:0046931) | 3.21031678 |
49 | regulation of protein heterodimerization activity (GO:0043497) | 3.20270598 |
50 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.17330648 |
51 | secondary heart field specification (GO:0003139) | 3.15326412 |
52 | heart field specification (GO:0003128) | 3.15326412 |
53 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.15080324 |
54 | DNA replication-independent nucleosome organization (GO:0034724) | 3.15080324 |
55 | L-serine metabolic process (GO:0006563) | 3.14289752 |
56 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.13513079 |
57 | negative regulation of DNA repair (GO:0045738) | 3.12952422 |
58 | cerebral cortex neuron differentiation (GO:0021895) | 3.12942035 |
59 | pancreas development (GO:0031016) | 3.12652478 |
60 | protein localization to chromosome, centromeric region (GO:0071459) | 3.12429851 |
61 | DNA ligation (GO:0006266) | 3.10785375 |
62 | regulation of striated muscle cell apoptotic process (GO:0010662) | 3.10148544 |
63 | positive regulation of TOR signaling (GO:0032008) | 3.09761224 |
64 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.09595733 |
65 | kinetochore assembly (GO:0051382) | 3.09021579 |
66 | DNA packaging (GO:0006323) | 3.08047280 |
67 | sister chromatid segregation (GO:0000819) | 3.08037226 |
68 | mitotic nuclear envelope disassembly (GO:0007077) | 3.07661452 |
69 | mitotic sister chromatid segregation (GO:0000070) | 3.01967453 |
70 | response to acidic pH (GO:0010447) | 2.95554265 |
71 | regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) | 2.95097593 |
72 | cell migration in hindbrain (GO:0021535) | 2.94091685 |
73 | protein deneddylation (GO:0000338) | 2.92905089 |
74 | mitotic metaphase plate congression (GO:0007080) | 2.92547690 |
75 | hemidesmosome assembly (GO:0031581) | 2.90810517 |
76 | mitotic G2/M transition checkpoint (GO:0044818) | 2.90532183 |
77 | mitotic sister chromatid cohesion (GO:0007064) | 2.88378320 |
78 | activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171) | 2.86908624 |
79 | nuclear envelope disassembly (GO:0051081) | 2.86873901 |
80 | membrane disassembly (GO:0030397) | 2.86873901 |
81 | nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423) | 2.86186571 |
82 | DNA strand elongation involved in DNA replication (GO:0006271) | 2.85981162 |
83 | apoptotic DNA fragmentation (GO:0006309) | 2.85966036 |
84 | mitotic recombination (GO:0006312) | 2.82563450 |
85 | serine family amino acid biosynthetic process (GO:0009070) | 2.82243036 |
86 | negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147) | 2.79454927 |
87 | spermatid nucleus differentiation (GO:0007289) | 2.75062661 |
88 | metaphase plate congression (GO:0051310) | 2.75038785 |
89 | regulation of smooth muscle cell differentiation (GO:0051150) | 2.73042213 |
90 | DNA strand elongation (GO:0022616) | 2.72572688 |
91 | telomere maintenance via recombination (GO:0000722) | 2.72005885 |
92 | regulation of centriole replication (GO:0046599) | 2.72002071 |
93 | negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244) | 2.70445697 |
94 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.69069350 |
95 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.69069350 |
96 | synapsis (GO:0007129) | 2.68518006 |
97 | superoxide anion generation (GO:0042554) | 2.68475183 |
98 | ATP-dependent chromatin remodeling (GO:0043044) | 2.68373754 |
99 | DNA double-strand break processing (GO:0000729) | 2.68215538 |
100 | DNA damage induced protein phosphorylation (GO:0006975) | 12.3125162 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 9.03348853 |
2 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 6.80782623 |
3 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 4.90871084 |
4 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 3.74649874 |
5 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.55831832 |
6 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.31788549 |
7 | * HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 3.11614325 |
8 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.01965245 |
9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.76706811 |
10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.59848858 |
11 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.43541697 |
12 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.37275628 |
13 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.31617088 |
14 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.20962855 |
15 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.19471567 |
16 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.14196427 |
17 | * POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.12295164 |
18 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.06003155 |
19 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.01460891 |
20 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.95820572 |
21 | FUS_26573619_Chip-Seq_HEK293_Human | 1.95357084 |
22 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.90738393 |
23 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.90738251 |
24 | * PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.88759280 |
25 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.85674901 |
26 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.81153366 |
27 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.69283797 |
28 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.68271157 |
29 | * EWS_26573619_Chip-Seq_HEK293_Human | 1.67963809 |
30 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.66329349 |
31 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.66108328 |
32 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.60725653 |
33 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.60675423 |
34 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.57001315 |
35 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.55968385 |
36 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.51991774 |
37 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.43991019 |
38 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.38108692 |
39 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.37502153 |
40 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.36623302 |
41 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 1.35043602 |
42 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.34198630 |
43 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.31600221 |
44 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.31566179 |
45 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.28175924 |
46 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.26792038 |
47 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.25377205 |
48 | * RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.24764677 |
49 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.23229345 |
50 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.21056812 |
51 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.19781135 |
52 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.19778535 |
53 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.19694309 |
54 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.19350395 |
55 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.18601952 |
56 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.16710497 |
57 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.14320018 |
58 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.13439628 |
59 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.11184320 |
60 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.10271689 |
61 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.09969769 |
62 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.07506276 |
63 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.06686110 |
64 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 1.05413764 |
65 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.04461077 |
66 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.98780553 |
67 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.98715302 |
68 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.97396924 |
69 | VDR_22108803_ChIP-Seq_LS180_Human | 0.96454745 |
70 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.96342754 |
71 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.95415916 |
72 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.93744148 |
73 | TP53_16413492_ChIP-PET_HCT116_Human | 0.92575225 |
74 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.92038840 |
75 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.91026163 |
76 | * PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.90624785 |
77 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.90575536 |
78 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.89631643 |
79 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.89301320 |
80 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.88934398 |
81 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.88573890 |
82 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.88557785 |
83 | * STAT3_23295773_ChIP-Seq_U87_Human | 0.88064273 |
84 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.85032799 |
85 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.84311203 |
86 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.83996442 |
87 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.83361807 |
88 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.81947545 |
89 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.81872270 |
90 | P300_19829295_ChIP-Seq_ESCs_Human | 0.81198516 |
91 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.80996065 |
92 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.80619500 |
93 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.80412244 |
94 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.77138870 |
95 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.76072328 |
96 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.75188991 |
97 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.74705433 |
98 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.74535957 |
99 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.71926044 |
100 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.71195968 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0009697_abnormal_copulation | 3.96759461 |
2 | MP0002163_abnormal_gland_morphology | 3.89710598 |
3 | MP0004133_heterotaxia | 3.75504632 |
4 | MP0008057_abnormal_DNA_replication | 3.60238280 |
5 | MP0004270_analgesia | 3.40264286 |
6 | MP0010094_abnormal_chromosome_stability | 3.21723054 |
7 | MP0003693_abnormal_embryo_hatching | 3.08634663 |
8 | MP0003890_abnormal_embryonic-extraembry | 3.02666082 |
9 | MP0003880_abnormal_central_pattern | 2.97078218 |
10 | MP0008058_abnormal_DNA_repair | 2.88674458 |
11 | MP0003077_abnormal_cell_cycle | 2.75542550 |
12 | MP0008775_abnormal_heart_ventricle | 2.69163687 |
13 | MP0006276_abnormal_autonomic_nervous | 2.54409614 |
14 | MP0003806_abnormal_nucleotide_metabolis | 2.52177136 |
15 | MP0004957_abnormal_blastocyst_morpholog | 2.40702351 |
16 | MP0005379_endocrine/exocrine_gland_phen | 2.30505444 |
17 | MP0004272_abnormal_basement_membrane | 2.25971450 |
18 | MP0003111_abnormal_nucleus_morphology | 2.24706052 |
19 | MP0008932_abnormal_embryonic_tissue | 2.22444281 |
20 | MP0002102_abnormal_ear_morphology | 2.09476045 |
21 | MP0003195_calcinosis | 2.04054689 |
22 | MP0004147_increased_porphyrin_level | 2.03243729 |
23 | MP0002127_abnormal_cardiovascular_syste | 1.93152570 |
24 | MP0000647_abnormal_sebaceous_gland | 1.78547600 |
25 | MP0008007_abnormal_cellular_replicative | 1.72117457 |
26 | MP0010352_gastrointestinal_tract_polyps | 1.56406122 |
27 | MP0006072_abnormal_retinal_apoptosis | 1.56309950 |
28 | MP0008995_early_reproductive_senescence | 1.52624259 |
29 | MP0005595_abnormal_vascular_smooth | 1.52512323 |
30 | MP0001529_abnormal_vocalization | 1.44289286 |
31 | MP0005646_abnormal_pituitary_gland | 1.42049576 |
32 | MP0003221_abnormal_cardiomyocyte_apopto | 1.39472330 |
33 | MP0008877_abnormal_DNA_methylation | 1.38692086 |
34 | MP0001697_abnormal_embryo_size | 1.34379309 |
35 | MP0002233_abnormal_nose_morphology | 1.31356307 |
36 | MP0000631_abnormal_neuroendocrine_gland | 1.29632685 |
37 | MP0002084_abnormal_developmental_patter | 1.28722941 |
38 | MP0010307_abnormal_tumor_latency | 1.28189267 |
39 | MP0005330_cardiomyopathy | 1.27717942 |
40 | MP0005171_absent_coat_pigmentation | 1.22890087 |
41 | MP0009672_abnormal_birth_weight | 1.22425391 |
42 | MP0003186_abnormal_redox_activity | 1.21537453 |
43 | MP0002396_abnormal_hematopoietic_system | 1.17570737 |
44 | MP0003763_abnormal_thymus_physiology | 1.17316106 |
45 | MP0001730_embryonic_growth_arrest | 1.17272949 |
46 | MP0000749_muscle_degeneration | 1.11766049 |
47 | MP0006035_abnormal_mitochondrial_morpho | 1.09303881 |
48 | MP0003786_premature_aging | 1.03929799 |
49 | MP0005380_embryogenesis_phenotype | 1.03644457 |
50 | MP0001672_abnormal_embryogenesis/_devel | 1.03644457 |
51 | MP0003718_maternal_effect | 1.01523062 |
52 | MP0002111_abnormal_tail_morphology | 1.01263735 |
53 | MP0002085_abnormal_embryonic_tissue | 0.99993205 |
54 | MP0004145_abnormal_muscle_electrophysio | 0.98775585 |
55 | MP0000358_abnormal_cell_content/ | 0.98649626 |
56 | MP0000372_irregular_coat_pigmentation | 0.98054492 |
57 | MP0006036_abnormal_mitochondrial_physio | 0.98029334 |
58 | MP0006054_spinal_hemorrhage | 0.97507085 |
59 | MP0000350_abnormal_cell_proliferation | 0.97202079 |
60 | MP0004811_abnormal_neuron_physiology | 0.93761966 |
61 | MP0005395_other_phenotype | 0.92887966 |
62 | MP0003937_abnormal_limbs/digits/tail_de | 0.91966970 |
63 | MP0002210_abnormal_sex_determination | 0.91703614 |
64 | MP0000313_abnormal_cell_death | 0.91440772 |
65 | MP0002168_other_aberrant_phenotype | 0.91436975 |
66 | MP0002972_abnormal_cardiac_muscle | 0.89548953 |
67 | MP0000778_abnormal_nervous_system | 0.88611790 |
68 | MP0001929_abnormal_gametogenesis | 0.88141256 |
69 | MP0009703_decreased_birth_body | 0.86841430 |
70 | MP0002080_prenatal_lethality | 0.86762477 |
71 | MP0004883_abnormal_blood_vessel | 0.86456925 |
72 | MP0003984_embryonic_growth_retardation | 0.86444537 |
73 | MP0004197_abnormal_fetal_growth/weight/ | 0.85060743 |
74 | MP0002088_abnormal_embryonic_growth/wei | 0.84726606 |
75 | MP0009250_abnormal_appendicular_skeleto | 0.82289332 |
76 | MP0000465_gastrointestinal_hemorrhage | 0.81775608 |
77 | MP0002751_abnormal_autonomic_nervous | 0.80308704 |
78 | MP0003121_genomic_imprinting | 0.77078759 |
79 | MP0005645_abnormal_hypothalamus_physiol | 0.76742165 |
80 | MP0004484_altered_response_of | 0.76486383 |
81 | MP0003448_altered_tumor_morphology | 0.74372393 |
82 | MP0001764_abnormal_homeostasis | 0.70776016 |
83 | MP0005075_abnormal_melanosome_morpholog | 0.70000511 |
84 | MP0004808_abnormal_hematopoietic_stem | 0.69631069 |
85 | MP0000653_abnormal_sex_gland | 0.68850254 |
86 | MP0005266_abnormal_metabolism | 0.68052634 |
87 | MP0005332_abnormal_amino_acid | 0.67133563 |
88 | MP0000428_abnormal_craniofacial_morphol | 0.65883076 |
89 | MP0001145_abnormal_male_reproductive | 0.65435764 |
90 | MP0010630_abnormal_cardiac_muscle | 0.65140820 |
91 | MP0003699_abnormal_female_reproductive | 0.64160425 |
92 | MP0001119_abnormal_female_reproductive | 0.63476466 |
93 | MP0001324_abnormal_eye_pigmentation | 0.62171451 |
94 | MP0005385_cardiovascular_system_phenoty | 0.61552846 |
95 | MP0001544_abnormal_cardiovascular_syste | 0.61552846 |
96 | MP0004084_abnormal_cardiac_muscle | 0.61413390 |
97 | MP0000427_abnormal_hair_cycle | 0.60473291 |
98 | MP0003861_abnormal_nervous_system | 0.59793545 |
99 | MP0000432_abnormal_head_morphology | 0.59636371 |
100 | MP0005195_abnormal_posterior_eye | 0.58818148 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Increased serum pyruvate (HP:0003542) | 7.43512951 |
2 | Esophageal atresia (HP:0002032) | 7.19244227 |
3 | Abnormality of glycolysis (HP:0004366) | 6.80438293 |
4 | Abnormality of the aortic arch (HP:0012303) | 6.45982825 |
5 | Aplasia cutis congenita (HP:0001057) | 6.33471099 |
6 | Gastrointestinal atresia (HP:0002589) | 5.14160314 |
7 | Small intestinal stenosis (HP:0012848) | 3.87762775 |
8 | Duodenal stenosis (HP:0100867) | 3.87762775 |
9 | Hypokinesia (HP:0002375) | 3.73859551 |
10 | Ragged-red muscle fibers (HP:0003200) | 3.56281921 |
11 | Chromsome breakage (HP:0040012) | 3.51776857 |
12 | Ureteral stenosis (HP:0000071) | 3.43247014 |
13 | Increased connective tissue (HP:0009025) | 3.42139444 |
14 | Ureteral obstruction (HP:0006000) | 3.42124196 |
15 | Pterygium (HP:0001059) | 3.35326602 |
16 | Curly hair (HP:0002212) | 3.33463268 |
17 | Abnormality of the duodenum (HP:0002246) | 3.32589046 |
18 | Atrioventricular canal defect (HP:0006695) | 3.27527414 |
19 | Papillary thyroid carcinoma (HP:0002895) | 3.25606914 |
20 | Ectropion (HP:0000656) | 3.22690422 |
21 | Abnormality of chromosome stability (HP:0003220) | 3.13237166 |
22 | Milia (HP:0001056) | 3.00666543 |
23 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.97860299 |
24 | Chronic hepatic failure (HP:0100626) | 2.96077610 |
25 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.94398322 |
26 | Tetraplegia (HP:0002445) | 2.82543419 |
27 | Hyperventilation (HP:0002883) | 2.75200887 |
28 | Thyroid carcinoma (HP:0002890) | 2.72654923 |
29 | Fragile skin (HP:0001030) | 2.70254227 |
30 | Rhabdomyosarcoma (HP:0002859) | 2.60858995 |
31 | Atrophic scars (HP:0001075) | 2.59701303 |
32 | Colon cancer (HP:0003003) | 2.55429770 |
33 | Microvesicular hepatic steatosis (HP:0001414) | 2.53876968 |
34 | Cortical dysplasia (HP:0002539) | 2.50298838 |
35 | Embryonal renal neoplasm (HP:0011794) | 2.42411593 |
36 | Abnormality of the labia minora (HP:0012880) | 2.40127892 |
37 | Increased CSF lactate (HP:0002490) | 2.38624493 |
38 | Cystic hygroma (HP:0000476) | 2.34355527 |
39 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.28987972 |
40 | Abnormality of the ileum (HP:0001549) | 2.28537696 |
41 | Meckel diverticulum (HP:0002245) | 2.26796697 |
42 | Hepatocellular necrosis (HP:0001404) | 2.24278614 |
43 | High anterior hairline (HP:0009890) | 2.21684367 |
44 | Atonic seizures (HP:0010819) | 2.19132492 |
45 | Abnormality of the prostate (HP:0008775) | 2.15706250 |
46 | Blue irides (HP:0000635) | 2.14954034 |
47 | Abnormality of pain sensation (HP:0010832) | 2.10190487 |
48 | Impaired pain sensation (HP:0007328) | 2.10190487 |
49 | Abnormality of the preputium (HP:0100587) | 2.07970488 |
50 | Hepatic necrosis (HP:0002605) | 2.05704902 |
51 | Large earlobe (HP:0009748) | 2.03885482 |
52 | Intrahepatic cholestasis (HP:0001406) | 2.03298132 |
53 | Molar tooth sign on MRI (HP:0002419) | 2.03074619 |
54 | Abnormality of midbrain morphology (HP:0002418) | 2.03074619 |
55 | Redundant skin (HP:0001582) | 2.02728574 |
56 | Delayed puberty (HP:0000823) | 2.01520184 |
57 | Volvulus (HP:0002580) | 2.01416299 |
58 | Abnormality of the fovea (HP:0000493) | 1.98699334 |
59 | Increased serum lactate (HP:0002151) | 1.98509248 |
60 | Diminished movement (HP:0002374) | 1.95848416 |
61 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.93093657 |
62 | Hypoplasia of the fovea (HP:0007750) | 1.93093657 |
63 | Medulloblastoma (HP:0002885) | 1.90852710 |
64 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.89918104 |
65 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.89918104 |
66 | Abnormality of the pancreatic islet cells (HP:0006476) | 1.87627901 |
67 | Abnormality of endocrine pancreas physiology (HP:0012093) | 1.87627901 |
68 | Shoulder girdle muscle weakness (HP:0003547) | 1.85380250 |
69 | Pelvic girdle muscle weakness (HP:0003749) | 1.85043430 |
70 | Astrocytoma (HP:0009592) | 1.83757966 |
71 | Abnormality of the astrocytes (HP:0100707) | 1.83757966 |
72 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.80473224 |
73 | Hypoglycemic seizures (HP:0002173) | 1.79953813 |
74 | Embryonal neoplasm (HP:0002898) | 1.78585430 |
75 | Sloping forehead (HP:0000340) | 1.78322492 |
76 | Nephronophthisis (HP:0000090) | 1.76466929 |
77 | Myelodysplasia (HP:0002863) | 1.75533163 |
78 | CNS demyelination (HP:0007305) | 1.71825588 |
79 | Tubulointerstitial nephritis (HP:0001970) | 1.70936970 |
80 | Rimmed vacuoles (HP:0003805) | 1.70506817 |
81 | Glioma (HP:0009733) | 1.68834550 |
82 | Acute myeloid leukemia (HP:0004808) | 1.68504740 |
83 | Short middle phalanx of finger (HP:0005819) | 1.63312032 |
84 | Abnormal lung lobation (HP:0002101) | 1.63260811 |
85 | Intestinal atresia (HP:0011100) | 1.61678787 |
86 | Hypophosphatemic rickets (HP:0004912) | 1.60759195 |
87 | Amblyopia (HP:0000646) | 1.60599402 |
88 | Increased nuchal translucency (HP:0010880) | 1.59586262 |
89 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.58104620 |
90 | Overlapping toe (HP:0001845) | 1.57757666 |
91 | Abnormality of the carotid arteries (HP:0005344) | 1.57352953 |
92 | Uterine neoplasm (HP:0010784) | 1.55857215 |
93 | Abnormality of male internal genitalia (HP:0000022) | 1.54697994 |
94 | Syringomyelia (HP:0003396) | 1.54501671 |
95 | Spinal cord lesions (HP:0100561) | 1.54501671 |
96 | Central scotoma (HP:0000603) | 1.53395001 |
97 | Fasciculations (HP:0002380) | 1.53228371 |
98 | Death in infancy (HP:0001522) | 1.51836023 |
99 | Chorioretinal coloboma (HP:0000567) | 1.51512373 |
100 | Abnormal gallbladder physiology (HP:0012438) | 1.49817269 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MAP2K6 | 5.76490395 |
2 | TLK1 | 4.87651534 |
3 | MAP3K5 | 3.46537491 |
4 | MAP4K2 | 3.16751062 |
5 | SIK2 | 2.34360706 |
6 | MAP3K8 | 2.06490547 |
7 | TAOK2 | 11.6112311 |
8 | TTK | 1.93906301 |
9 | NME1 | 1.77080661 |
10 | EEF2K | 1.67203018 |
11 | WEE1 | 1.40566440 |
12 | BUB1 | 1.31330455 |
13 | MST4 | 1.28832777 |
14 | MAPKAPK3 | 1.23985106 |
15 | SRPK1 | 1.14943126 |
16 | BRSK2 | 1.10764608 |
17 | EIF2AK3 | 1.09833478 |
18 | CASK | 1.08737762 |
19 | FRK | 1.08387625 |
20 | TRPM7 | 1.02413752 |
21 | BCR | 0.99839223 |
22 | CDC7 | 0.98714608 |
23 | NEK1 | 0.97270426 |
24 | TRIM28 | 0.96956452 |
25 | EIF2AK1 | 0.95944635 |
26 | PLK3 | 0.93818753 |
27 | CCNB1 | 0.90939976 |
28 | MAPKAPK5 | 0.85667119 |
29 | PLK4 | 0.83635205 |
30 | PBK | 0.80826127 |
31 | RPS6KB2 | 0.80810151 |
32 | RIPK1 | 0.79472606 |
33 | SIK3 | 0.77804718 |
34 | CSNK1G3 | 0.75436070 |
35 | CSNK1G1 | 0.72813476 |
36 | TSSK6 | 0.70942628 |
37 | NUAK1 | 0.69983750 |
38 | MAPK13 | 0.64717410 |
39 | MKNK1 | 0.64234583 |
40 | BRD4 | 0.63820213 |
41 | RIPK4 | 0.62681799 |
42 | MKNK2 | 0.61612950 |
43 | CSNK1A1L | 0.60684614 |
44 | CSNK1G2 | 0.60365126 |
45 | STK39 | 0.60126849 |
46 | PIK3CA | 0.59678227 |
47 | PLK1 | 0.59384048 |
48 | STK4 | 0.58609639 |
49 | ATR | 0.58313038 |
50 | TAF1 | 0.58111732 |
51 | OXSR1 | 0.58103721 |
52 | WNK3 | 0.51914186 |
53 | VRK1 | 0.51660115 |
54 | WNK4 | 0.51628505 |
55 | TNIK | 0.46442864 |
56 | CHEK2 | 0.45081499 |
57 | PLK2 | 0.41845730 |
58 | ERBB3 | 0.40199215 |
59 | ZAK | 0.39329698 |
60 | MELK | 0.39325769 |
61 | ATM | 0.38449865 |
62 | YES1 | 0.37543771 |
63 | BRSK1 | 0.37015954 |
64 | MAP3K4 | 0.34967021 |
65 | VRK2 | 0.32143628 |
66 | SCYL2 | 0.31615994 |
67 | EIF2AK2 | 0.31541620 |
68 | MARK3 | 0.30597705 |
69 | STK3 | 0.30402589 |
70 | STK16 | 0.30067106 |
71 | AURKA | 0.29877180 |
72 | FGFR2 | 0.28998633 |
73 | AURKB | 0.24394071 |
74 | MAP3K2 | 0.24392847 |
75 | CDK8 | 0.23456806 |
76 | HIPK2 | 0.23142848 |
77 | NLK | 0.22314222 |
78 | KSR1 | 0.22204592 |
79 | NTRK3 | 0.21494163 |
80 | MINK1 | 0.19508779 |
81 | CHEK1 | 0.17040142 |
82 | CDK1 | 0.16869715 |
83 | BMPR1B | 0.16026773 |
84 | RAF1 | 0.15553559 |
85 | NEK2 | 0.15017377 |
86 | CSNK2A1 | 0.13740686 |
87 | CDK3 | 0.12918484 |
88 | FGFR1 | 0.12570442 |
89 | DYRK3 | 0.12417071 |
90 | FLT3 | 0.10856227 |
91 | EPHA3 | 0.09695251 |
92 | RPS6KA4 | 0.08142699 |
93 | CSNK1A1 | 0.07993820 |
94 | MAP2K7 | 0.07936197 |
95 | CDK2 | 0.07932366 |
96 | PDK2 | 0.07714102 |
97 | RET | 0.07024351 |
98 | PASK | 0.06099903 |
99 | NEK6 | 0.05408582 |
100 | CSNK2A2 | 0.05069956 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Mismatch repair_Homo sapiens_hsa03430 | 3.84501894 |
2 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 3.49821864 |
3 | DNA replication_Homo sapiens_hsa03030 | 3.39678769 |
4 | Non-homologous end-joining_Homo sapiens_hsa03450 | 3.25685060 |
5 | Homologous recombination_Homo sapiens_hsa03440 | 3.20734795 |
6 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.58169023 |
7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.57954649 |
8 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 2.51598342 |
9 | Cell cycle_Homo sapiens_hsa04110 | 2.37250901 |
10 | RNA transport_Homo sapiens_hsa03013 | 2.25343253 |
11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.21835011 |
12 | Basal transcription factors_Homo sapiens_hsa03022 | 2.09879640 |
13 | Selenocompound metabolism_Homo sapiens_hsa00450 | 2.05688550 |
14 | Proteasome_Homo sapiens_hsa03050 | 2.01405124 |
15 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.96640136 |
16 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.92583848 |
17 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.92252350 |
18 | RNA degradation_Homo sapiens_hsa03018 | 1.88152263 |
19 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.86031359 |
20 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.77080906 |
21 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.73889381 |
22 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.70498045 |
23 | Base excision repair_Homo sapiens_hsa03410 | 1.65728091 |
24 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.63423463 |
25 | Protein export_Homo sapiens_hsa03060 | 1.62106659 |
26 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.59140448 |
27 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.57981516 |
28 | Spliceosome_Homo sapiens_hsa03040 | 1.56716809 |
29 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.51084842 |
30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.45355091 |
31 | RNA polymerase_Homo sapiens_hsa03020 | 1.43442749 |
32 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.36670216 |
33 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.35681772 |
34 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.33685823 |
35 | Purine metabolism_Homo sapiens_hsa00230 | 1.28290636 |
36 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.27910894 |
37 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.22863783 |
38 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.15775384 |
39 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.13117068 |
40 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.12668179 |
41 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.09572438 |
42 | Carbon metabolism_Homo sapiens_hsa01200 | 1.06619283 |
43 | Parkinsons disease_Homo sapiens_hsa05012 | 1.05278851 |
44 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.04930214 |
45 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.04864785 |
46 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.00692427 |
47 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.98787933 |
48 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.94360398 |
49 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.92710661 |
50 | Cocaine addiction_Homo sapiens_hsa05030 | 0.90087625 |
51 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.87968983 |
52 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.79784512 |
53 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.79349708 |
54 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.78736714 |
55 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.77763542 |
56 | Alcoholism_Homo sapiens_hsa05034 | 0.75467829 |
57 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.74775059 |
58 | Influenza A_Homo sapiens_hsa05164 | 0.70771741 |
59 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.70582081 |
60 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.70383705 |
61 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.70041632 |
62 | Circadian rhythm_Homo sapiens_hsa04710 | 0.64817706 |
63 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.63321234 |
64 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.62578420 |
65 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.61775067 |
66 | Phototransduction_Homo sapiens_hsa04744 | 0.60632595 |
67 | Peroxisome_Homo sapiens_hsa04146 | 0.58133158 |
68 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.57062297 |
69 | Alzheimers disease_Homo sapiens_hsa05010 | 0.51244868 |
70 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.50142146 |
71 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.48157136 |
72 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.47676042 |
73 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.44931203 |
74 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.41284918 |
75 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.39961780 |
76 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.39127833 |
77 | Metabolic pathways_Homo sapiens_hsa01100 | 0.39004880 |
78 | Endometrial cancer_Homo sapiens_hsa05213 | 0.38857099 |
79 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.37396440 |
80 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.37191521 |
81 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.37026665 |
82 | Huntingtons disease_Homo sapiens_hsa05016 | 0.34188267 |
83 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.33315864 |
84 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.33153345 |
85 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.32903633 |
86 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.31984680 |
87 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.31464499 |
88 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.29919513 |
89 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.29554748 |
90 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.29417135 |
91 | Olfactory transduction_Homo sapiens_hsa04740 | 0.26416787 |
92 | Prostate cancer_Homo sapiens_hsa05215 | 0.26291298 |
93 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.26199744 |
94 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.25781829 |
95 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.25517049 |
96 | Lysine degradation_Homo sapiens_hsa00310 | 0.24628406 |
97 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.23564208 |
98 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.21178946 |
99 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.18102201 |
100 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.16374733 |