ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fusion of sperm to egg plasma membrane (GO:0007342)	7.92038257
2	cellular ketone body metabolic process (GO:0046950)	6.83308697
3	ketone body metabolic process (GO:1902224)	6.00557044
4	plasma membrane fusion (GO:0045026)	5.94210194
5	establishment of protein localization to Golgi (GO:0072600)	4.97849115
6	regulation of cytokine production involved in inflammatory response (GO:1900015)	4.70819606
7	protein targeting to Golgi (GO:0000042)	4.68701202
8	regulation of centriole replication (GO:0046599)	4.60838622
9	adaptation of signaling pathway (GO:0023058)	4.48285251
10	adenosine metabolic process (GO:0046085)	4.47182417
11	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.40476809
12	sperm motility (GO:0030317)	4.39012065
13	regulation of acrosome reaction (GO:0060046)	4.25165319
14	multicellular organism reproduction (GO:0032504)	4.22084946
15	cellular biogenic amine biosynthetic process (GO:0042401)	4.16942443
16	embryonic viscerocranium morphogenesis (GO:0048703)	4.16298545
17	centriole replication (GO:0007099)	4.13829537
18	seminiferous tubule development (GO:0072520)	4.03352611
19	amine biosynthetic process (GO:0009309)	3.96053571
20	detection of temperature stimulus (GO:0016048)	3.92080551
21	indolalkylamine metabolic process (GO:0006586)	3.85707549
22	musculoskeletal movement (GO:0050881)	3.80223093
23	multicellular organismal movement (GO:0050879)	3.80223093
24	cilium or flagellum-dependent cell motility (GO:0001539)	3.71916317
25	sperm-egg recognition (GO:0035036)	3.71153571
26	polyamine biosynthetic process (GO:0006596)	3.59332966
27	retina homeostasis (GO:0001895)	3.58015279
28	protein localization to Golgi apparatus (GO:0034067)	3.53249423
29	regulation of male gonad development (GO:2000018)	3.52838037
30	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.52382941
31	short-chain fatty acid metabolic process (GO:0046459)	3.52050600
32	retinal metabolic process (GO:0042574)	3.48470642
33	negative regulation of sodium ion transport (GO:0010766)	3.46864000
34	iron ion import (GO:0097286)	3.45372584
35	negative regulation of protein localization to cell surface (GO:2000009)	3.44245358
36	response to nitrosative stress (GO:0051409)	3.38865376
37	positive regulation of male gonad development (GO:2000020)	3.27058345
38	import into cell (GO:0098657)	3.24284863
39	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.18010347
40	sperm capacitation (GO:0048240)	3.12837216
41	benzene-containing compound metabolic process (GO:0042537)	3.11829502
42	regulation of female gonad development (GO:2000194)	3.11759258
43	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.09509409
44	cell-cell recognition (GO:0009988)	3.09486741
45	male sex determination (GO:0030238)	3.08736909
46	protein polyglutamylation (GO:0018095)	3.05070610
47	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.05041694
48	L-phenylalanine catabolic process (GO:0006559)	3.05041694
49	detection of light stimulus involved in sensory perception (GO:0050962)	3.04969045
50	detection of light stimulus involved in visual perception (GO:0050908)	3.04969045
51	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.04812507
52	regulation of centrosome duplication (GO:0010824)	3.04161428
53	protein prenylation (GO:0018342)	3.03947027
54	prenylation (GO:0097354)	3.03947027
55	gonadal mesoderm development (GO:0007506)	3.03913036
56	segment specification (GO:0007379)	3.03861376
57	aromatic amino acid family catabolic process (GO:0009074)	3.02432543
58	reflex (GO:0060004)	3.01382920
59	tryptophan catabolic process (GO:0006569)	3.00113298
60	indole-containing compound catabolic process (GO:0042436)	3.00113298
61	indolalkylamine catabolic process (GO:0046218)	3.00113298
62	regulation of Golgi to plasma membrane protein transport (GO:0042996)	2.97819227
63	valine metabolic process (GO:0006573)	2.94805555
64	sulfation (GO:0051923)	2.94777116
65	centriole assembly (GO:0098534)	2.94751742
66	GMP metabolic process (GO:0046037)	2.91955316
67	platelet dense granule organization (GO:0060155)	2.89104718
68	rhodopsin mediated signaling pathway (GO:0016056)	2.87808594
69	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.87437702
70	branched-chain amino acid metabolic process (GO:0009081)	2.87224600
71	piRNA metabolic process (GO:0034587)	2.86700210
72	negative regulation of metanephros development (GO:0072217)	2.85564444
73	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.81268353
74	branching involved in prostate gland morphogenesis (GO:0060442)	2.81180512
75	amine catabolic process (GO:0009310)	2.80340891
76	cellular biogenic amine catabolic process (GO:0042402)	2.80340891
77	axoneme assembly (GO:0035082)	2.79794744
78	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.78027104
79	reproduction (GO:0000003)	2.77916441
80	sterol catabolic process (GO:0016127)	2.75157112
81	cholesterol catabolic process (GO:0006707)	2.75157112
82	positive regulation of guanylate cyclase activity (GO:0031284)	2.74565273
83	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.74066294
84	male genitalia development (GO:0030539)	2.72742525
85	respiratory chain complex IV assembly (GO:0008535)	2.71540840
86	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.71192846
87	L-phenylalanine metabolic process (GO:0006558)	2.71192846
88	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.69444726
89	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	2.66935388
90	single fertilization (GO:0007338)	2.66718278
91	auditory receptor cell stereocilium organization (GO:0060088)	2.66489670
92	thrombin receptor signaling pathway (GO:0070493)	2.65606204
93	sex determination (GO:0007530)	2.64318522
94	mitochondrial calcium ion transport (GO:0006851)	2.63698295
95	regulation of centrosome cycle (GO:0046605)	2.63552621
96	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.63192250
97	organic cation transport (GO:0015695)	2.56585690
98	kynurenine metabolic process (GO:0070189)	2.54459557
99	indole-containing compound metabolic process (GO:0042430)	2.49101059
100	heme transport (GO:0015886)	2.49078594

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.61483222
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.21975606
3	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.06378430
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.01063642
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.84899667
6	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.74206709
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.44185111
8	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.23960131
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.21823315
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.15952717
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.07900657
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.93524030
13	GBX2_23144817_ChIP-Seq_PC3_Human	1.91314061
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.90888522
15	EWS_26573619_Chip-Seq_HEK293_Human	1.90018779
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.88153174
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.87935610
18	P300_19829295_ChIP-Seq_ESCs_Human	1.84408266
19	HTT_18923047_ChIP-ChIP_STHdh_Human	1.82131970
20	EZH2_22144423_ChIP-Seq_EOC_Human	1.77087058
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.75887049
22	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.75166034
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.73209551
24	BCAT_22108803_ChIP-Seq_LS180_Human	1.68115961
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.67719679
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.65525381
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.64671523
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62410938
29	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.54749721
30	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.53293153
31	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.52615802
32	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.51895157
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51675537
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.51675537
35	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.51341921
36	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.46286965
37	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.46173732
38	* STAT3_23295773_ChIP-Seq_U87_Human	1.45744065
39	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.44950173
40	* TCF4_23295773_ChIP-Seq_U87_Human	1.44790688
41	FUS_26573619_Chip-Seq_HEK293_Human	1.41753735
42	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.41318234
43	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.41293887
44	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.38286354
45	NCOR_22424771_ChIP-Seq_293T_Human	1.37052559
46	ERG_20517297_ChIP-Seq_VCAP_Human	1.36122962
47	AR_21572438_ChIP-Seq_LNCaP_Human	1.35449066
48	AR_21909140_ChIP-Seq_LNCAP_Human	1.34852557
49	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.34615706
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31424349
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.30746029
52	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30439887
53	CDX2_22108803_ChIP-Seq_LS180_Human	1.29745480
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.28647993
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.28647993
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.28163204
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28163204
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.27635704
59	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.27496503
60	GATA3_26560356_Chip-Seq_TH2_Human	1.27463241
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26979701
62	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.26380048
63	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.26318303
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24780492
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23822036
66	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23822036
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23711999
68	AR_20517297_ChIP-Seq_VCAP_Human	1.23547284
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.22956508
70	TP53_22573176_ChIP-Seq_HFKS_Human	1.21992939
71	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.20428803
72	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.20409215
73	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.20154038
74	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.19550013
75	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.18992175
76	P53_21459846_ChIP-Seq_SAOS-2_Human	1.17980009
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.15957318
78	PHF8_20622853_ChIP-Seq_HELA_Human	1.14943459
79	EGR1_19032775_ChIP-ChIP_M12_Human	1.13436934
80	CEBPB_22108803_ChIP-Seq_LS180_Human	1.12899263
81	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.11734559
82	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.10394714
83	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09893084
84	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.09325125
85	AHR_22903824_ChIP-Seq_MCF-7_Human	1.08739547
86	MYC_19829295_ChIP-Seq_ESCs_Human	1.08463353
87	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.08245777
88	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07935053
89	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.07684837
90	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.07601000
91	RBPJ_21746931_ChIP-Seq_IB4_Human	1.07133708
92	GATA4_25053715_ChIP-Seq_YYC3_Human	1.06013963
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.05537368
94	AR_25329375_ChIP-Seq_VCAP_Human	1.04829918
95	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.02565552
96	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.01906323
97	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.00586007
98	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.00357364
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00310223
100	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.99503208

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	6.41827947
2	MP0002736_abnormal_nociception_after	4.07554079
3	MP0005410_abnormal_fertilization	3.29624993
4	MP0005377_hearing/vestibular/ear_phenot	3.21973329
5	MP0003878_abnormal_ear_physiology	3.21973329
6	MP0003195_calcinosis	2.90328955
7	MP0005167_abnormal_blood-brain_barrier	2.83617906
8	MP0001968_abnormal_touch/_nociception	2.73697383
9	MP0005379_endocrine/exocrine_gland_phen	2.72238760
10	MP0005551_abnormal_eye_electrophysiolog	2.41081828
11	MP0008995_early_reproductive_senescence	2.33539679
12	MP0003011_delayed_dark_adaptation	2.26566073
13	MP0004043_abnormal_pH_regulation	2.23805531
14	MP0002653_abnormal_ependyma_morphology	2.22885618
15	MP0003828_pulmonary_edema	2.19659472
16	MP0001348_abnormal_lacrimal_gland	2.16809227
17	MP0001661_extended_life_span	2.05837384
18	MP0002735_abnormal_chemical_nociception	2.03755386
19	MP0003879_abnormal_hair_cell	1.79380333
20	MP0003123_paternal_imprinting	1.73637828
21	MP0005310_abnormal_salivary_gland	1.70252818
22	MP0005670_abnormal_white_adipose	1.69739369
23	MP0005464_abnormal_platelet_physiology	1.67661329
24	MP0003698_abnormal_male_reproductive	1.64291627
25	MP0006276_abnormal_autonomic_nervous	1.64177686
26	MP0003045_fibrosis	1.60953022
27	MP0005636_abnormal_mineral_homeostasis	1.59664394
28	MP0003718_maternal_effect	1.56023817
29	MP0001485_abnormal_pinna_reflex	1.50530739
30	MP0002234_abnormal_pharynx_morphology	1.50045374
31	MP0001929_abnormal_gametogenesis	1.49800506
32	MP0000383_abnormal_hair_follicle	1.44941697
33	MP0001764_abnormal_homeostasis	1.44923369
34	MP0002733_abnormal_thermal_nociception	1.42252724
35	MP0005646_abnormal_pituitary_gland	1.41368243
36	MP0003950_abnormal_plasma_membrane	1.37587564
37	MP0002928_abnormal_bile_duct	1.31263447
38	MP0005647_abnormal_sex_gland	1.31088109
39	MP0001919_abnormal_reproductive_system	1.30719485
40	MP0002837_dystrophic_cardiac_calcinosis	1.28976558
41	MP0005085_abnormal_gallbladder_physiolo	1.26637811
42	MP0002876_abnormal_thyroid_physiology	1.25592435
43	MP0003252_abnormal_bile_duct	1.25103986
44	MP0004147_increased_porphyrin_level	1.23416561
45	MP0008877_abnormal_DNA_methylation	1.18569278
46	MP0008004_abnormal_stomach_pH	1.17171423
47	MP0000631_abnormal_neuroendocrine_gland	1.15919185
48	MP0001765_abnormal_ion_homeostasis	1.15670352
49	MP0009333_abnormal_splenocyte_physiolog	1.12549981
50	MP0005253_abnormal_eye_physiology	1.12490996
51	MP0003638_abnormal_response/metabolism_	1.10695441
52	MP0003137_abnormal_impulse_conducting	1.10526299
53	MP0005389_reproductive_system_phenotype	1.08806152
54	MP0005395_other_phenotype	1.06523580
55	MP0001664_abnormal_digestion	1.06298583
56	MP0003136_yellow_coat_color	1.05011595
57	MP0009643_abnormal_urine_homeostasis	1.03773262
58	MP0001727_abnormal_embryo_implantation	0.99976228
59	MP0000653_abnormal_sex_gland	0.99664244
60	MP0002210_abnormal_sex_determination	0.99530472
61	MP0001486_abnormal_startle_reflex	0.99071499
62	MP0005365_abnormal_bile_salt	0.98956693
63	MP0002090_abnormal_vision	0.97677007
64	MP0003806_abnormal_nucleotide_metabolis	0.95271130
65	MP0004019_abnormal_vitamin_homeostasis	0.91642142
66	MP0000230_abnormal_systemic_arterial	0.90675560
67	MP0000516_abnormal_urinary_system	0.90121586
68	MP0005367_renal/urinary_system_phenotyp	0.90121586
69	MP0005332_abnormal_amino_acid	0.89914849
70	MP0004742_abnormal_vestibular_system	0.86139134
71	MP0002127_abnormal_cardiovascular_syste	0.85472190
72	MP0003866_abnormal_defecation	0.84862447
73	MP0002168_other_aberrant_phenotype	0.83559896
74	MP0003890_abnormal_embryonic-extraembry	0.83300404
75	MP0003943_abnormal_hepatobiliary_system	0.81873692
76	MP0006138_congestive_heart_failure	0.81429697
77	MP0000026_abnormal_inner_ear	0.81252263
78	MP0001970_abnormal_pain_threshold	0.79918622
79	MP0008875_abnormal_xenobiotic_pharmacok	0.79892933
80	MP0002161_abnormal_fertility/fecundity	0.79575247
81	MP0001119_abnormal_female_reproductive	0.79232677
82	MP0004085_abnormal_heartbeat	0.79041371
83	MP0001145_abnormal_male_reproductive	0.78319845
84	MP0008872_abnormal_physiological_respon	0.75060858
85	MP0003786_premature_aging	0.72438441
86	MP0004134_abnormal_chest_morphology	0.72353138
87	MP0003936_abnormal_reproductive_system	0.71721183
88	MP0001270_distended_abdomen	0.69316986
89	MP0000613_abnormal_salivary_gland	0.68199608
90	MP0003183_abnormal_peptide_metabolism	0.66497509
91	MP0002160_abnormal_reproductive_system	0.65685152
92	MP0002095_abnormal_skin_pigmentation	0.65212228
93	MP0003646_muscle_fatigue	0.64717885
94	MP0002136_abnormal_kidney_physiology	0.63559112
95	MP0002138_abnormal_hepatobiliary_system	0.62897423
96	MP0000372_irregular_coat_pigmentation	0.61810697
97	MP0010329_abnormal_lipoprotein_level	0.61377923
98	MP0002132_abnormal_respiratory_system	0.60400181
99	MP0000427_abnormal_hair_cycle	0.60352083
100	MP0005671_abnormal_response_to	0.60275940

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.66688193
2	Chronic hepatic failure (HP:0100626)	4.31190434
3	Generalized aminoaciduria (HP:0002909)	4.14817924
4	Attenuation of retinal blood vessels (HP:0007843)	3.93470599
5	Pancreatic cysts (HP:0001737)	3.87495844
6	Male infertility (HP:0003251)	3.87373381
7	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.63937673
8	Diaphragmatic weakness (HP:0009113)	3.47194335
9	Gonadal dysgenesis (HP:0000133)	3.45817495
10	Mixed hearing impairment (HP:0000410)	3.39111144
11	Spontaneous abortion (HP:0005268)	3.17854270
12	Renal cortical cysts (HP:0000803)	3.13688503
13	Cerebellar dysplasia (HP:0007033)	3.03081051
14	Tinnitus (HP:0000360)	2.93865706
15	Male pseudohermaphroditism (HP:0000037)	2.93278295
16	Pancreatic fibrosis (HP:0100732)	2.93156608
17	Occipital encephalocele (HP:0002085)	2.86718629
18	Hyperglycinuria (HP:0003108)	2.77123448
19	Renal Fanconi syndrome (HP:0001994)	2.71754597
20	Abnormality of the nasal septum (HP:0000419)	2.68883960
21	Abnormality of the renal cortex (HP:0011035)	2.60720333
22	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.58387537
23	Ketoacidosis (HP:0001993)	2.57764606
24	Nausea (HP:0002018)	2.56383855
25	Ileus (HP:0002595)	2.54043803
26	Bony spicule pigmentary retinopathy (HP:0007737)	2.46437289
27	Congenital stationary night blindness (HP:0007642)	2.41503145
28	Decreased central vision (HP:0007663)	2.41418597
29	Abnormality of urine glucose concentration (HP:0011016)	2.39812978
30	Glycosuria (HP:0003076)	2.39812978
31	Increased CSF lactate (HP:0002490)	2.38291218
32	Cystic liver disease (HP:0006706)	2.37355952
33	Fibular aplasia (HP:0002990)	2.35783535
34	Type II lissencephaly (HP:0007260)	2.35381576
35	Short tibia (HP:0005736)	2.33301855
36	Retinal atrophy (HP:0001105)	2.30450891
37	Amelogenesis imperfecta (HP:0000705)	2.28617514
38	Proximal tubulopathy (HP:0000114)	2.26524403
39	Abnormal drinking behavior (HP:0030082)	2.25631220
40	Polydipsia (HP:0001959)	2.25631220
41	Abnormal rod and cone electroretinograms (HP:0008323)	2.22672543
42	Abnormality of renal resorption (HP:0011038)	2.22634551
43	3-Methylglutaconic aciduria (HP:0003535)	2.22013478
44	Hypophosphatemic rickets (HP:0004912)	2.19687216
45	Hepatic necrosis (HP:0002605)	2.19488730
46	Abnormality of serine family amino acid metabolism (HP:0010894)	2.14339561
47	Abnormality of glycine metabolism (HP:0010895)	2.14339561
48	Acanthocytosis (HP:0001927)	2.13411737
49	Abnormality of the lumbar spine (HP:0100712)	2.10670740
50	Constricted visual fields (HP:0001133)	2.09774645
51	Hepatocellular necrosis (HP:0001404)	2.09177074
52	Retinal dysplasia (HP:0007973)	2.08776318
53	Gingival bleeding (HP:0000225)	2.07084825
54	Ketosis (HP:0001946)	2.06850322
55	Anomalous pulmonary venous return (HP:0010772)	2.06199210
56	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.05291137
57	Tubulointerstitial nephritis (HP:0001970)	2.04261306
58	Aplastic anemia (HP:0001915)	2.03484920
59	Poikilocytosis (HP:0004447)	2.02805348
60	Hypoalbuminemia (HP:0003073)	2.02184276
61	Abnormal albumin level (HP:0012116)	2.02184276
62	Mitochondrial inheritance (HP:0001427)	2.01924053
63	Intrahepatic cholestasis (HP:0001406)	2.01783197
64	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.00721466
65	Embryonal renal neoplasm (HP:0011794)	2.00173682
66	Abnormality of alanine metabolism (HP:0010916)	1.98865785
67	Hyperalaninemia (HP:0003348)	1.98865785
68	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.98865785
69	Decreased circulating renin level (HP:0003351)	1.95623659
70	Depressed nasal tip (HP:0000437)	1.95503860
71	Sclerocornea (HP:0000647)	1.94534834
72	Hyponatremia (HP:0002902)	1.92833482
73	Nephroblastoma (Wilms tumor) (HP:0002667)	1.92528099
74	Degeneration of anterior horn cells (HP:0002398)	1.91325782
75	Abnormality of the anterior horn cell (HP:0006802)	1.91325782
76	Pancreatic islet-cell hyperplasia (HP:0004510)	1.91135889
77	Gaze-evoked nystagmus (HP:0000640)	1.89729570
78	Papillary thyroid carcinoma (HP:0002895)	1.89068378
79	Portal hypertension (HP:0001409)	1.85771956
80	Abnormality of the common coagulation pathway (HP:0010990)	1.85288526
81	Small hand (HP:0200055)	1.83052534
82	Absent/shortened dynein arms (HP:0200106)	1.81771372
83	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.81771372
84	Petechiae (HP:0000967)	1.80759577
85	Prolonged bleeding time (HP:0003010)	1.80338354
86	Abnormal pupillary function (HP:0007686)	1.80187435
87	Abnormality of the costochondral junction (HP:0000919)	1.79878752
88	Abnormality of the pulmonary veins (HP:0011718)	1.79530471
89	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.79198919
90	Abnormal respiratory motile cilium physiology (HP:0012261)	1.78014774
91	Polyuria (HP:0000103)	1.77210152
92	Abnormality of endocrine pancreas physiology (HP:0012093)	1.76434254
93	Abnormality of the pancreatic islet cells (HP:0006476)	1.76434254
94	Abnormality of macular pigmentation (HP:0008002)	1.76131770
95	Epistaxis (HP:0000421)	1.75894402
96	Hyperglycinemia (HP:0002154)	1.75100875
97	Molar tooth sign on MRI (HP:0002419)	1.74875675
98	Abnormality of midbrain morphology (HP:0002418)	1.74875675
99	Enlarged kidneys (HP:0000105)	1.72873056
100	Acute encephalopathy (HP:0006846)	1.71543507

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	7.27440632
2	INSRR	6.11128023
3	AKT3	3.73570514
4	NUAK1	3.71360349
5	PLK4	3.59888006
6	BRD4	3.41347301
7	PBK	2.95458794
8	STK3	2.50299949
9	ACVR1B	2.31118268
10	TXK	2.13852423
11	TESK2	2.02415480
12	EIF2AK3	2.01036553
13	ERBB3	1.79264248
14	NME1	1.72814616
15	ZAK	1.71135586
16	KDR	1.70577922
17	FRK	1.68981240
18	TAOK3	1.52922938
19	PDK2	1.42129956
20	SGK2	1.32370326
21	BMX	1.22232531
22	TEC	1.21556106
23	BUB1	1.10031168
24	TNK2	1.04450985
25	CCNB1	1.02507262
26	ADRBK2	1.00050449
27	OXSR1	0.92713250
28	STK39	0.88894562
29	WNK4	0.85104186
30	CDK19	0.84814815
31	NEK2	0.83646506
32	VRK1	0.82458546
33	CAMK1D	0.80552795
34	SCYL2	0.79041724
35	PRKCQ	0.77392369
36	CAMK1G	0.76471948
37	SGK494	0.76023215
38	SGK223	0.76023215
39	GRK1	0.73198029
40	MYLK	0.69981864
41	EIF2AK2	0.69828147
42	PTK2B	0.67456880
43	BMPR2	0.65960684
44	TLK1	0.65433369
45	NME2	0.65431208
46	ITK	0.65393578
47	MATK	0.64787106
48	BMPR1B	0.63790304
49	MAP3K2	0.62729374
50	PHKG1	0.59338117
51	PHKG2	0.59338117
52	SGK3	0.56273007
53	TAOK2	0.56077322
54	STK38L	0.55291849
55	BRSK2	0.55277751
56	MKNK1	0.53261897
57	WNK3	0.52601230
58	DAPK2	0.51570528
59	CHEK2	0.51100168
60	PDK1	0.47194312
61	ADRBK1	0.46758466
62	NTRK3	0.44500613
63	OBSCN	0.44068083
64	PRKAA1	0.42885252
65	STK4	0.40607702
66	TTK	0.39320784
67	MKNK2	0.38789632
68	MAP2K1	0.38131597
69	PRKACA	0.36497105
70	PRKACG	0.35788462
71	KSR2	0.35055672
72	NEK1	0.34001309
73	CDC7	0.32877210
74	WEE1	0.32638909
75	ERBB2	0.32261830
76	TRPM7	0.30154206
77	RIPK4	0.30013878
78	BTK	0.29303406
79	JAK3	0.29293531
80	MAP3K7	0.28881569
81	PRKD3	0.28744708
82	PLK1	0.28535257
83	PLK2	0.27410714
84	PRKG1	0.26702177
85	LCK	0.26373048
86	PRKAA2	0.25884883
87	ICK	0.25427491
88	BRSK1	0.25322038
89	STK38	0.25083547
90	PIM1	0.25066336
91	STK16	0.24715101
92	PRKCG	0.24379424
93	MAP2K6	0.24186943
94	EIF2AK1	0.24154534
95	PRKCB	0.24122037
96	CDK7	0.23847079
97	MAP2K2	0.23112624
98	MARK3	0.22724108
99	PRKCE	0.22571192
100	PRKCA	0.21880041

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.03184241
2	Butanoate metabolism_Homo sapiens_hsa00650	3.76211595
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.40193587
4	ABC transporters_Homo sapiens_hsa02010	2.92383020
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.89722899
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.75171498
7	beta-Alanine metabolism_Homo sapiens_hsa00410	2.73442239
8	Olfactory transduction_Homo sapiens_hsa04740	2.43619206
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.39437221
10	Propanoate metabolism_Homo sapiens_hsa00640	2.35979435
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.25401546
12	Phototransduction_Homo sapiens_hsa04744	2.10134501
13	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.03564710
14	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.82187705
15	Phenylalanine metabolism_Homo sapiens_hsa00360	1.74877391
16	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.72967911
17	Primary immunodeficiency_Homo sapiens_hsa05340	1.68716019
18	Retinol metabolism_Homo sapiens_hsa00830	1.65036821
19	Taste transduction_Homo sapiens_hsa04742	1.61601426
20	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.61179515
21	RNA polymerase_Homo sapiens_hsa03020	1.60696862
22	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.59901277
23	Tyrosine metabolism_Homo sapiens_hsa00350	1.59552722
24	One carbon pool by folate_Homo sapiens_hsa00670	1.59356224
25	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.51758454
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.50747883
27	Sulfur metabolism_Homo sapiens_hsa00920	1.49177655
28	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.45529283
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.44563963
30	Serotonergic synapse_Homo sapiens_hsa04726	1.41170399
31	Oxidative phosphorylation_Homo sapiens_hsa00190	1.37020419
32	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.32295939
33	Chemical carcinogenesis_Homo sapiens_hsa05204	1.28577558
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.28202364
35	Fatty acid degradation_Homo sapiens_hsa00071	1.26559258
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.25562117
37	Fatty acid metabolism_Homo sapiens_hsa01212	1.25390998
38	Fat digestion and absorption_Homo sapiens_hsa04975	1.15168658
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14217576
40	Ribosome_Homo sapiens_hsa03010	1.13218675
41	Peroxisome_Homo sapiens_hsa04146	1.12150125
42	Huntingtons disease_Homo sapiens_hsa05016	1.11788102
43	Purine metabolism_Homo sapiens_hsa00230	1.07809247
44	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.06859875
45	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.06275133
46	Glutathione metabolism_Homo sapiens_hsa00480	1.04777083
47	Parkinsons disease_Homo sapiens_hsa05012	1.02640531
48	Histidine metabolism_Homo sapiens_hsa00340	1.02380088
49	Bile secretion_Homo sapiens_hsa04976	1.02000068
50	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.01401865
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.96920013
52	Fanconi anemia pathway_Homo sapiens_hsa03460	0.95565653
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.94166848
54	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.88283316
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.84291408
56	Pyrimidine metabolism_Homo sapiens_hsa00240	0.84219230
57	PPAR signaling pathway_Homo sapiens_hsa03320	0.81922947
58	Homologous recombination_Homo sapiens_hsa03440	0.78473028
59	Fatty acid elongation_Homo sapiens_hsa00062	0.75942031
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.72584285
61	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.72042286
62	Platelet activation_Homo sapiens_hsa04611	0.72016974
63	RNA transport_Homo sapiens_hsa03013	0.70506906
64	Metabolic pathways_Homo sapiens_hsa01100	0.70473116
65	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.70408654
66	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.69122071
67	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.69013056
68	Calcium signaling pathway_Homo sapiens_hsa04020	0.64789105
69	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.62716477
70	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.59392665
71	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.56888621
72	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.55796210
73	Alzheimers disease_Homo sapiens_hsa05010	0.52444912
74	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.46311564
75	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.44481686
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.43686669
77	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.43439951
78	Pancreatic secretion_Homo sapiens_hsa04972	0.40841397
79	Sulfur relay system_Homo sapiens_hsa04122	0.39794513
80	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38370040
81	Basal transcription factors_Homo sapiens_hsa03022	0.37670902
82	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.36462751
83	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.35073679
84	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.34871180
85	Non-homologous end-joining_Homo sapiens_hsa03450	0.34005199
86	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.33409167
87	Mineral absorption_Homo sapiens_hsa04978	0.33325385
88	Base excision repair_Homo sapiens_hsa03410	0.32878494
89	Arginine biosynthesis_Homo sapiens_hsa00220	0.32355847
90	Proteasome_Homo sapiens_hsa03050	0.32013624
91	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.29983804
92	Morphine addiction_Homo sapiens_hsa05032	0.28839270
93	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.27952193
94	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.26294046
95	Melanoma_Homo sapiens_hsa05218	0.24785342
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.22898563
97	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.20328637
98	Nicotine addiction_Homo sapiens_hsa05033	0.19963872
99	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.18651515
100	Cardiac muscle contraction_Homo sapiens_hsa04260	0.16369175

POTEB

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »