POTEB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.65738442
2sperm motility (GO:0030317)9.57121180
3spermatid development (GO:0007286)8.28626753
4male meiosis (GO:0007140)8.13797268
5piRNA metabolic process (GO:0034587)7.91658410
6binding of sperm to zona pellucida (GO:0007339)7.58802005
7fusion of sperm to egg plasma membrane (GO:0007342)7.16011280
8sperm-egg recognition (GO:0035036)7.15896631
9multicellular organism reproduction (GO:0032504)6.92757749
10motile cilium assembly (GO:0044458)6.53856273
11synapsis (GO:0007129)6.40719504
12axonemal dynein complex assembly (GO:0070286)6.29396787
13cell-cell recognition (GO:0009988)6.02569682
14DNA methylation involved in gamete generation (GO:0043046)5.85077942
15phosphatidylethanolamine biosynthetic process (GO:0006646)5.71210458
16cilium or flagellum-dependent cell motility (GO:0001539)5.59157866
17plasma membrane fusion (GO:0045026)5.53117938
18reproduction (GO:0000003)5.52186679
19regulation of phosphoprotein phosphatase activity (GO:0043666)5.48531946
20sperm capacitation (GO:0048240)5.38862906
21protein polyglutamylation (GO:0018095)5.37481980
22negative regulation of inclusion body assembly (GO:0090084)5.32277500
23phosphatidylethanolamine metabolic process (GO:0046337)5.21950440
24polyamine biosynthetic process (GO:0006596)5.18610159
25calcium ion-dependent exocytosis (GO:0017156)5.10529924
26germ cell development (GO:0007281)5.04168288
27spermatid nucleus differentiation (GO:0007289)4.93363842
28regulation of meiosis I (GO:0060631)4.92398022
29epithelial cilium movement (GO:0003351)4.85687639
30single fertilization (GO:0007338)4.83893345
31regulation of cilium movement (GO:0003352)4.79992262
32single strand break repair (GO:0000012)4.69405284
33organic cation transport (GO:0015695)4.68204555
34microtubule depolymerization (GO:0007019)4.63642881
35positive regulation of catecholamine secretion (GO:0033605)4.61480347
36spermatogenesis (GO:0007283)4.59280094
37male gamete generation (GO:0048232)4.58800152
38chromosome condensation (GO:0030261)4.53761677
39DNA packaging (GO:0006323)4.43522775
40microtubule severing (GO:0051013)4.30976282
41gamete generation (GO:0007276)4.23782807
42meiotic nuclear division (GO:0007126)4.20464893
43cellular process involved in reproduction in multicellular organism (GO:0022412)4.19176241
44cellular ketone body metabolic process (GO:0046950)4.16603281
45cilium movement (GO:0003341)4.08623551
46fertilization (GO:0009566)4.02146141
47nucleosome disassembly (GO:0006337)4.01283963
48protein-DNA complex disassembly (GO:0032986)4.01283963
49cellular biogenic amine biosynthetic process (GO:0042401)3.90534588
50chromosome organization involved in meiosis (GO:0070192)3.89250865
51establishment of protein localization to Golgi (GO:0072600)3.87703268
52histone exchange (GO:0043486)3.82315150
53protein targeting to Golgi (GO:0000042)3.80158011
54relaxation of smooth muscle (GO:0044557)3.76810514
55ketone body metabolic process (GO:1902224)3.74392572
56oogenesis (GO:0048477)3.73496455
57DNA double-strand break processing (GO:0000729)3.70524983
58regulation of inclusion body assembly (GO:0090083)3.70422422
59amine biosynthetic process (GO:0009309)3.69474486
60histone H3-K9 demethylation (GO:0033169)3.67905566
61centriole assembly (GO:0098534)3.63261246
62rRNA methylation (GO:0031167)3.59762669
63microtubule polymerization or depolymerization (GO:0031109)3.57203768
64potassium ion export (GO:0071435)3.57178123
65regulation of dopamine secretion (GO:0014059)3.49168048
66detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.48666093
67male meiosis I (GO:0007141)3.47124602
68positive regulation of meiotic cell cycle (GO:0051446)3.44933998
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.44427010
70regulation of histone H3-K9 methylation (GO:0051570)3.43665380
71rRNA modification (GO:0000154)3.43336684
72multicellular organismal reproductive process (GO:0048609)3.35826636
73response to acidic pH (GO:0010447)3.33057641
74retrograde transport, vesicle recycling within Golgi (GO:0000301)3.32741106
75regulation of centriole replication (GO:0046599)3.31654113
76positive regulation of meiosis (GO:0045836)3.30240796
77protein localization to Golgi apparatus (GO:0034067)3.28559611
78ventricular system development (GO:0021591)3.22526178
79male sex determination (GO:0030238)3.21026313
80polyamine metabolic process (GO:0006595)3.18400321
81coenzyme catabolic process (GO:0009109)3.17317695
82response to pheromone (GO:0019236)3.13542857
83centriole replication (GO:0007099)3.13302167
84regulation of microtubule-based movement (GO:0060632)3.08355752
85female gamete generation (GO:0007292)3.06036350
86gene silencing by RNA (GO:0031047)3.05006296
87meiotic cell cycle (GO:0051321)2.90053062
88gonadal mesoderm development (GO:0007506)2.89445786
89meiosis I (GO:0007127)2.86557401
90tachykinin receptor signaling pathway (GO:0007217)2.85619446
91androgen biosynthetic process (GO:0006702)2.85584937
92leukotriene biosynthetic process (GO:0019370)2.81392113
93regulation of female gonad development (GO:2000194)2.79166197
94DNA synthesis involved in DNA repair (GO:0000731)2.78955110
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.78123433
96acrosome assembly (GO:0001675)2.75261588
97regulation of mitochondrial translation (GO:0070129)2.75210859
98response to misfolded protein (GO:0051788)2.74556228
99regulation of Rab GTPase activity (GO:0032313)2.73598634
100positive regulation of Rab GTPase activity (GO:0032851)2.73598634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.96226541
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.93743851
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.50177582
4EZH2_22144423_ChIP-Seq_EOC_Human3.86361863
5IGF1R_20145208_ChIP-Seq_DFB_Human3.62529236
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.26186361
7VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.93885903
8VDR_22108803_ChIP-Seq_LS180_Human2.82102347
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.78381227
10ZNF274_21170338_ChIP-Seq_K562_Hela2.25315841
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12393633
12CBP_20019798_ChIP-Seq_JUKART_Human2.03389082
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.03389082
14ERA_21632823_ChIP-Seq_H3396_Human1.97131579
15NANOG_20526341_ChIP-Seq_ESCs_Human1.92367488
16FUS_26573619_Chip-Seq_HEK293_Human1.89324723
17ER_23166858_ChIP-Seq_MCF-7_Human1.88449276
18ERG_20517297_ChIP-Seq_VCAP_Human1.88448562
19GBX2_23144817_ChIP-Seq_PC3_Human1.82715824
20OCT4_20526341_ChIP-Seq_ESCs_Human1.82702929
21IRF1_19129219_ChIP-ChIP_H3396_Human1.77224123
22RAC3_21632823_ChIP-Seq_H3396_Human1.76726654
23TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76206748
24POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.76206748
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67760965
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66976863
27WDR5_24793694_ChIP-Seq_LNCAP_Human1.66882644
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.62335791
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61368684
30ELF1_20517297_ChIP-Seq_JURKAT_Human1.57013488
31MYC_19829295_ChIP-Seq_ESCs_Human1.56809974
32RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.56597048
33CTCF_20526341_ChIP-Seq_ESCs_Human1.54963069
34SMAD4_21741376_ChIP-Seq_EPCs_Human1.54198560
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.52591108
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51614076
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50855914
38FOXH1_21741376_ChIP-Seq_EPCs_Human1.49763636
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48565043
40OCT1_27270436_Chip-Seq_PROSTATE_Human1.47319119
41YY1_22570637_ChIP-Seq_MALME-3M_Human1.45679867
42PHF8_20622854_ChIP-Seq_HELA_Human1.45300242
43P300_27268052_Chip-Seq_Bcells_Human1.43755527
44BCAT_22108803_ChIP-Seq_LS180_Human1.43534625
45EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.42360430
46PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.42320117
47AR_25329375_ChIP-Seq_VCAP_Human1.38657407
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38170804
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37932113
50KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36616802
51AUTS2_25519132_ChIP-Seq_293T-REX_Human1.36159812
52PHF8_20622853_ChIP-Seq_HELA_Human1.34013285
53CTCF_27219007_Chip-Seq_Bcells_Human1.33959183
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33380264
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32212140
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.31427154
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.31036857
58CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.29986019
59HNFA_21074721_ChIP-Seq_CACO-2_Human1.28070142
60NFYB_21822215_ChIP-Seq_K562_Human1.27426816
61STAT3_23295773_ChIP-Seq_U87_Human1.27054659
62P300_19829295_ChIP-Seq_ESCs_Human1.25944941
63SOX2_19829295_ChIP-Seq_ESCs_Human1.25481699
64NANOG_19829295_ChIP-Seq_ESCs_Human1.25481699
65TBL1_22424771_ChIP-Seq_293T_Human1.25379230
66E2F1_17053090_ChIP-ChIP_MCF-7_Human1.22839499
67HOXB7_26014856_ChIP-Seq_BT474_Human1.21782623
68RBPJ_21746931_ChIP-Seq_IB4_Human1.20525566
69RUNX2_22187159_ChIP-Seq_PCA_Human1.20203758
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.19740020
71CBX2_22325352_ChIP-Seq_293T-Rex_Human1.17755535
72SMC4_20622854_ChIP-Seq_HELA_Human1.17416842
73BCL6_27268052_Chip-Seq_Bcells_Human1.15977253
74AR_21572438_ChIP-Seq_LNCaP_Human1.15946231
75P68_20966046_ChIP-Seq_HELA_Human1.15485379
76SMAD4_21799915_ChIP-Seq_A2780_Human1.14762915
77NFYA_21822215_ChIP-Seq_K562_Human1.13943092
78SPI1_20517297_ChIP-Seq_HL60_Human1.13792085
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13636342
80ETV1_20927104_ChIP-Seq_GIST48_Human1.13534132
81NCOR_22424771_ChIP-Seq_293T_Human1.12748097
82E2F1_20622854_ChIP-Seq_HELA_Human1.11368974
83DROSHA_22980978_ChIP-Seq_HELA_Human1.10708967
84GATA6_21074721_ChIP-Seq_CACO-2_Human1.10598098
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.10420155
86FOXH1_21741376_ChIP-Seq_ESCs_Human1.08502406
87TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07202816
88TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.06809365
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06045754
90ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05144310
91PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04862542
92GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03726568
93GATA3_26560356_Chip-Seq_TH1_Human1.02982450
94BCOR_27268052_Chip-Seq_Bcells_Human1.01624908
95TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00937666
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00596331
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99873228
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98881991
99OCT4_19829295_ChIP-Seq_ESCs_Human0.96018770
100TP53_22573176_ChIP-Seq_HFKS_Human0.94050413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.59541116
2MP0003698_abnormal_male_reproductive4.11496338
3MP0001929_abnormal_gametogenesis3.98497017
4MP0008004_abnormal_stomach_pH3.17450182
5MP0003718_maternal_effect2.96312912
6MP0009697_abnormal_copulation2.95083489
7MP0005377_hearing/vestibular/ear_phenot2.76718910
8MP0003878_abnormal_ear_physiology2.76718910
9MP0002210_abnormal_sex_determination2.59114808
10MP0005670_abnormal_white_adipose2.53667424
11MP0005647_abnormal_sex_gland2.47674582
12MP0002161_abnormal_fertility/fecundity2.29014445
13MP0003806_abnormal_nucleotide_metabolis2.17598881
14MP0001145_abnormal_male_reproductive2.16819187
15MP0002160_abnormal_reproductive_system2.16596077
16MP0003646_muscle_fatigue2.13252701
17MP0000653_abnormal_sex_gland2.13109472
18MP0008058_abnormal_DNA_repair2.01455358
19MP0003315_abnormal_perineum_morphology1.99259330
20MP0002132_abnormal_respiratory_system1.89856644
21MP0008995_early_reproductive_senescence1.86638357
22MP0002736_abnormal_nociception_after1.75663788
23MP0005451_abnormal_body_composition1.74649569
24MP0002822_catalepsy1.74152308
25MP0008877_abnormal_DNA_methylation1.69509901
26MP0004147_increased_porphyrin_level1.56713234
27MP0005360_urolithiasis1.54306451
28MP0003693_abnormal_embryo_hatching1.52878852
29MP0001968_abnormal_touch/_nociception1.51097309
30MP0003879_abnormal_hair_cell1.44889648
31MP0005551_abnormal_eye_electrophysiolog1.41290327
32MP0000372_irregular_coat_pigmentation1.39557842
33MP0001501_abnormal_sleep_pattern1.35991887
34MP0010368_abnormal_lymphatic_system1.34650592
35MP0005395_other_phenotype1.23158666
36MP0003136_yellow_coat_color1.21371972
37MP0001485_abnormal_pinna_reflex1.21125725
38MP0001664_abnormal_digestion1.14380880
39MP0010386_abnormal_urinary_bladder1.14187489
40MP0002102_abnormal_ear_morphology1.11456304
41MP0010094_abnormal_chromosome_stability1.11103436
42MP0001905_abnormal_dopamine_level1.10173329
43MP0006035_abnormal_mitochondrial_morpho1.09906964
44MP0006036_abnormal_mitochondrial_physio1.08663567
45MP0003950_abnormal_plasma_membrane1.06744960
46MP0003699_abnormal_female_reproductive1.05329660
47MP0001873_stomach_inflammation1.01374224
48MP0001984_abnormal_olfaction1.01083457
49MP0004084_abnormal_cardiac_muscle1.01060109
50MP0005058_abnormal_lysosome_morphology1.00560277
51MP0001963_abnormal_hearing_physiology0.98919005
52MP0001764_abnormal_homeostasis0.98754316
53MP0006276_abnormal_autonomic_nervous0.98652017
54MP0003252_abnormal_bile_duct0.95395255
55MP0004036_abnormal_muscle_relaxation0.95185942
56MP0002928_abnormal_bile_duct0.94558861
57MP0002735_abnormal_chemical_nociception0.92909393
58MP0001188_hyperpigmentation0.92245602
59MP0005389_reproductive_system_phenotype0.91404363
60MP0002138_abnormal_hepatobiliary_system0.90400163
61MP0000230_abnormal_systemic_arterial0.90064972
62MP0003183_abnormal_peptide_metabolism0.89718201
63MP0003077_abnormal_cell_cycle0.88737011
64MP0001666_abnormal_nutrient_absorption0.87806149
65MP0003786_premature_aging0.87636596
66MP0004957_abnormal_blastocyst_morpholog0.86733298
67MP0002272_abnormal_nervous_system0.85344693
68MP0001661_extended_life_span0.85044702
69MP0001119_abnormal_female_reproductive0.84625431
70MP0000470_abnormal_stomach_morphology0.83722049
71MP0005394_taste/olfaction_phenotype0.81326610
72MP0005499_abnormal_olfactory_system0.81326610
73MP0000465_gastrointestinal_hemorrhage0.81281914
74MP0003111_abnormal_nucleus_morphology0.80207003
75MP0004233_abnormal_muscle_weight0.78428019
76MP0005636_abnormal_mineral_homeostasis0.76309138
77MP0003936_abnormal_reproductive_system0.76027274
78MP0001486_abnormal_startle_reflex0.74768969
79MP0003045_fibrosis0.74103404
80MP0002229_neurodegeneration0.73903343
81MP0003656_abnormal_erythrocyte_physiolo0.72683903
82MP0002733_abnormal_thermal_nociception0.72385081
83MP0005174_abnormal_tail_pigmentation0.71605324
84MP0000678_abnormal_parathyroid_gland0.71424948
85MP0008770_decreased_survivor_rate0.70630699
86MP0004085_abnormal_heartbeat0.70219832
87MP0001765_abnormal_ion_homeostasis0.68679066
88MP0005253_abnormal_eye_physiology0.67364979
89MP0004142_abnormal_muscle_tone0.66130930
90MP0002127_abnormal_cardiovascular_syste0.63900312
91MP0009745_abnormal_behavioral_response0.63213259
92MP0005397_hematopoietic_system_phenotyp0.62418561
93MP0001545_abnormal_hematopoietic_system0.62418561
94MP0002557_abnormal_social/conspecific_i0.61489039
95MP0008057_abnormal_DNA_replication0.60326783
96MP0001348_abnormal_lacrimal_gland0.60216574
97MP0000631_abnormal_neuroendocrine_gland0.60200661
98MP0000538_abnormal_urinary_bladder0.57037587
99MP0005646_abnormal_pituitary_gland0.56420718
100MP0009046_muscle_twitch0.55947373

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.09646695
2Absent/shortened dynein arms (HP:0200106)6.09646695
3Abnormal ciliary motility (HP:0012262)5.33573752
4Abnormal respiratory motile cilium physiology (HP:0012261)5.17045253
5Tubulointerstitial nephritis (HP:0001970)5.06160263
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.88227649
7Resting tremor (HP:0002322)4.76457672
8Abnormal respiratory epithelium morphology (HP:0012253)4.72279791
9Abnormal respiratory motile cilium morphology (HP:0005938)4.72279791
10Infertility (HP:0000789)4.52602467
11Sex reversal (HP:0012245)4.03314860
12Abnormal sex determination (HP:0012244)4.03314860
13Gonadal dysgenesis (HP:0000133)3.94548530
14Abnormality of macular pigmentation (HP:0008002)3.91440409
15Attenuation of retinal blood vessels (HP:0007843)3.58331029
16Severe visual impairment (HP:0001141)3.54003816
17Bony spicule pigmentary retinopathy (HP:0007737)3.47993575
18Male pseudohermaphroditism (HP:0000037)3.44556809
19Hypoplasia of the uterus (HP:0000013)3.22705854
20Abnormality of dental color (HP:0011073)3.22162408
21Abnormal rod and cone electroretinograms (HP:0008323)3.20305157
22Chronic hepatic failure (HP:0100626)3.08704788
23Postural instability (HP:0002172)3.08621898
24Retinal dysplasia (HP:0007973)2.97486838
25Cerebellar dysplasia (HP:0007033)2.95848894
26Rhinitis (HP:0012384)2.91339458
27Congenital sensorineural hearing impairment (HP:0008527)2.91291549
28Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.87266087
29Reduced antithrombin III activity (HP:0001976)2.80485670
30Hyperglycinuria (HP:0003108)2.75141174
31Type II lissencephaly (HP:0007260)2.74121691
32Male infertility (HP:0003251)2.67241446
33Aplasia/hypoplasia of the uterus (HP:0008684)2.65977889
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.63436037
35Thoracic kyphosis (HP:0002942)2.61522964
36Febrile seizures (HP:0002373)2.60270211
37Impulsivity (HP:0100710)2.54584462
38Bronchiectasis (HP:0002110)2.47477096
39Hyperkalemia (HP:0002153)2.43931237
40Abnormal spermatogenesis (HP:0008669)2.42862809
41Azoospermia (HP:0000027)2.39244577
42Nephronophthisis (HP:0000090)2.37793140
43Progressive cerebellar ataxia (HP:0002073)2.36312397
44Hyperglycinemia (HP:0002154)2.34701963
45Facial diplegia (HP:0001349)2.29099176
46Nasal polyposis (HP:0100582)2.21966930
47Gonadotropin excess (HP:0000837)2.20706237
48Protruding tongue (HP:0010808)2.20205229
49Tubulointerstitial abnormality (HP:0001969)2.19706435
50Generalized aminoaciduria (HP:0002909)2.13686709
51Decreased central vision (HP:0007663)2.03802453
52Retinal atrophy (HP:0001105)2.02244756
53Chronic bronchitis (HP:0004469)2.00690578
54Aplasia/Hypoplasia of the earlobes (HP:0009906)1.99399637
55Aplasia/Hypoplasia of the fovea (HP:0008060)1.98951302
56Hypoplasia of the fovea (HP:0007750)1.98951302
57Abnormal protein glycosylation (HP:0012346)1.93872768
58Abnormal glycosylation (HP:0012345)1.93872768
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93872768
60Abnormal protein N-linked glycosylation (HP:0012347)1.93872768
61Abnormality of the lumbar spine (HP:0100712)1.90818451
62Abnormality of the heme biosynthetic pathway (HP:0010472)1.90552031
63Abnormality of the fovea (HP:0000493)1.90184401
64Abnormality of the thoracic spine (HP:0100711)1.89714120
65Degeneration of the lateral corticospinal tracts (HP:0002314)1.87964220
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87964220
67Abnormality of the corticospinal tract (HP:0002492)1.87231970
68Urinary urgency (HP:0000012)1.86724187
69Peripheral hypomyelination (HP:0007182)1.85471557
70Inability to walk (HP:0002540)1.84916718
71Absent thumb (HP:0009777)1.84519817
72Hand muscle atrophy (HP:0009130)1.83053889
73Upper limb muscle weakness (HP:0003484)1.79513872
74Bell-shaped thorax (HP:0001591)1.79377071
75Occipital encephalocele (HP:0002085)1.77168283
76Supernumerary spleens (HP:0009799)1.76666411
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.76644287
78Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76644287
79Abnormality of serine family amino acid metabolism (HP:0010894)1.76132103
80Abnormality of glycine metabolism (HP:0010895)1.76132103
81Abnormality of DNA repair (HP:0003254)1.75535981
82Fibular aplasia (HP:0002990)1.73862885
83Colitis (HP:0002583)1.73183119
84Abnormal drinking behavior (HP:0030082)1.72880439
85Polydipsia (HP:0001959)1.72880439
86Type II diabetes mellitus (HP:0005978)1.71730172
87Abnormal gallbladder physiology (HP:0012438)1.70742368
88Cholecystitis (HP:0001082)1.70742368
89Abnormality of the renal medulla (HP:0100957)1.69684230
90Rhabdomyolysis (HP:0003201)1.68970275
91Cystic liver disease (HP:0006706)1.68133806
92Pancreatic cysts (HP:0001737)1.67702669
93Abnormality of the ileum (HP:0001549)1.66999212
94Photophobia (HP:0000613)1.66428929
95Ketosis (HP:0001946)1.66226904
96Abnormality of the costochondral junction (HP:0000919)1.65911697
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.63327842
98Hypergonadotropic hypogonadism (HP:0000815)1.62995239
99Clumsiness (HP:0002312)1.62855862
100Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62701270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK16.41000443
2ZAK4.27181139
3PLK43.58084344
4MARK33.43641140
5TLK12.92830644
6SCYL22.63156929
7WNK42.34298496
8NEK22.32581744
9FRK2.30933053
10TESK22.25509179
11MAP3K92.21661198
12ARAF2.20516428
13CCNB12.09826063
14DYRK32.07404094
15RPS6KA51.99575086
16TESK11.92843201
17STK381.81193855
18STK38L1.74760047
19PIK3CG1.70170282
20MYLK1.64286920
21MAP3K131.61591540
22MST1R1.49940988
23STK391.49918858
24AKT31.42611204
25MAP4K21.42453182
26ACVR1B1.37638895
27BRAF1.33093388
28MATK1.32421840
29PNCK1.31475040
30WNK11.26936935
31EIF2AK31.24755568
32BCKDK1.14628470
33RAF11.14025578
34INSRR1.09089932
35PRKG21.02276775
36KSR20.99717602
37MAPK150.94140576
38LATS10.88375463
39EIF2AK10.87151557
40STK160.85397858
41PTK2B0.84138392
42NEK60.82132530
43SRPK10.81590640
44TTK0.81043847
45PRKCQ0.76734528
46CDK40.75974727
47VRK10.71043661
48CDK30.70203332
49EPHA40.69935701
50RIPK40.69071655
51BMPR1B0.67594210
52DDR20.67140248
53BLK0.64865909
54PRKD30.58719820
55ATM0.57758768
56MAP3K20.54776085
57PLK10.54281343
58STK30.53224104
59PKN10.53217825
60MUSK0.49973624
61CASK0.48761596
62CDK70.48582712
63KIT0.48267474
64ADRBK20.47268097
65BTK0.46607997
66PRKG10.46539233
67MAP3K10.44532620
68AURKA0.44478982
69SIK20.44424953
70GRK10.44236926
71NME20.43946448
72PDPK10.41613363
73CAMK1G0.41476149
74ATR0.41452362
75PDK10.41155595
76PAK20.40788464
77PASK0.40402615
78PAK10.40122908
79TEC0.39400459
80PLK20.35127184
81WEE10.34013623
82MAPK110.33612196
83OBSCN0.32957728
84CHEK10.32599201
85MAP3K80.31692703
86CDK140.31061488
87PIM10.30944977
88MAPK130.29845828
89RPS6KB10.29382020
90KDR0.29278079
91NEK10.27964271
92BRSK10.27576295
93CHEK20.27153536
94PIM20.25963207
95CDK10.25698123
96BRSK20.25320563
97AURKB0.24538148
98SGK2230.24109041
99SGK4940.24109041
100PRKACB0.24069848

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.10758017
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.80428478
3Olfactory transduction_Homo sapiens_hsa047403.24633220
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.92809317
5Butanoate metabolism_Homo sapiens_hsa006502.66842531
6Basal transcription factors_Homo sapiens_hsa030222.54716464
7Propanoate metabolism_Homo sapiens_hsa006402.46553008
8Arginine biosynthesis_Homo sapiens_hsa002202.24589581
9Gap junction_Homo sapiens_hsa045402.15847831
10Nitrogen metabolism_Homo sapiens_hsa009102.01540699
11Selenocompound metabolism_Homo sapiens_hsa004501.96646451
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95737522
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.87294981
14Fanconi anemia pathway_Homo sapiens_hsa034601.85249936
15Fatty acid degradation_Homo sapiens_hsa000711.83301041
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.78615651
17Base excision repair_Homo sapiens_hsa034101.68288465
18Fatty acid metabolism_Homo sapiens_hsa012121.67576012
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.62570888
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.55837212
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.55163386
22RNA transport_Homo sapiens_hsa030131.54128514
23Taste transduction_Homo sapiens_hsa047421.53985173
24Dorso-ventral axis formation_Homo sapiens_hsa043201.52893827
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52853600
26Nicotine addiction_Homo sapiens_hsa050331.47179669
27Oocyte meiosis_Homo sapiens_hsa041141.46631967
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.40202988
29Systemic lupus erythematosus_Homo sapiens_hsa053221.33818261
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30407710
31ABC transporters_Homo sapiens_hsa020101.28831820
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25762892
33Regulation of autophagy_Homo sapiens_hsa041401.18719982
34Apoptosis_Homo sapiens_hsa042101.17638501
35Alcoholism_Homo sapiens_hsa050341.15484400
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07504074
37Glutathione metabolism_Homo sapiens_hsa004801.01122416
38Chemical carcinogenesis_Homo sapiens_hsa052040.98573200
39Purine metabolism_Homo sapiens_hsa002300.97573862
40Homologous recombination_Homo sapiens_hsa034400.97022371
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96886655
42Tryptophan metabolism_Homo sapiens_hsa003800.92698352
43Hedgehog signaling pathway_Homo sapiens_hsa043400.91544134
44PPAR signaling pathway_Homo sapiens_hsa033200.91406350
45RNA degradation_Homo sapiens_hsa030180.88403980
46Linoleic acid metabolism_Homo sapiens_hsa005910.87614793
47Retinol metabolism_Homo sapiens_hsa008300.85595997
48Mismatch repair_Homo sapiens_hsa034300.82636350
49Caffeine metabolism_Homo sapiens_hsa002320.82179001
50Peroxisome_Homo sapiens_hsa041460.81587410
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79920757
52Phenylalanine metabolism_Homo sapiens_hsa003600.79641913
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79515610
54Calcium signaling pathway_Homo sapiens_hsa040200.75763111
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75057604
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74461195
57Metabolic pathways_Homo sapiens_hsa011000.73423073
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72899969
59Phototransduction_Homo sapiens_hsa047440.72782377
60Arginine and proline metabolism_Homo sapiens_hsa003300.72280992
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.71445291
62Pyrimidine metabolism_Homo sapiens_hsa002400.71202679
63beta-Alanine metabolism_Homo sapiens_hsa004100.69911387
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69458807
65Fat digestion and absorption_Homo sapiens_hsa049750.69199392
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69038515
67Tyrosine metabolism_Homo sapiens_hsa003500.68857480
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68408495
69mRNA surveillance pathway_Homo sapiens_hsa030150.67880203
70Phagosome_Homo sapiens_hsa041450.66816016
71Sulfur relay system_Homo sapiens_hsa041220.65433119
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64176421
73Inositol phosphate metabolism_Homo sapiens_hsa005620.63606875
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.61127839
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.60891444
76DNA replication_Homo sapiens_hsa030300.60172349
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.58659427
78Nucleotide excision repair_Homo sapiens_hsa034200.57497734
79Sphingolipid metabolism_Homo sapiens_hsa006000.57161075
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54424961
81Synaptic vesicle cycle_Homo sapiens_hsa047210.51687949
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49265911
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48730542
84Pentose phosphate pathway_Homo sapiens_hsa000300.46773435
85Serotonergic synapse_Homo sapiens_hsa047260.46301911
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46036911
87Arachidonic acid metabolism_Homo sapiens_hsa005900.44631443
88N-Glycan biosynthesis_Homo sapiens_hsa005100.43611295
89Circadian entrainment_Homo sapiens_hsa047130.42028169
90One carbon pool by folate_Homo sapiens_hsa006700.40881343
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40039229
92Salivary secretion_Homo sapiens_hsa049700.39675693
93Morphine addiction_Homo sapiens_hsa050320.38953737
94Circadian rhythm_Homo sapiens_hsa047100.38085648
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37638817
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36817416
97Glycerolipid metabolism_Homo sapiens_hsa005610.36364658
98Vitamin digestion and absorption_Homo sapiens_hsa049770.36095055
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36061533
100Cell cycle_Homo sapiens_hsa041100.34575242

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »