ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein K11-linked deubiquitination (GO:0035871)	6.00298879
2	indole-containing compound catabolic process (GO:0042436)	5.47955939
3	indolalkylamine catabolic process (GO:0046218)	5.47955939
4	tryptophan catabolic process (GO:0006569)	5.47955939
5	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.90089850
6	indolalkylamine metabolic process (GO:0006586)	4.82149707
7	kynurenine metabolic process (GO:0070189)	4.61022648
8	tryptophan metabolic process (GO:0006568)	4.59937858
9	cilium or flagellum-dependent cell motility (GO:0001539)	4.45425712
10	neural tube formation (GO:0001841)	4.30182497
11	piRNA metabolic process (GO:0034587)	3.99881135
12	signal peptide processing (GO:0006465)	3.93787476
13	protein K48-linked deubiquitination (GO:0071108)	3.90910723
14	photoreceptor cell maintenance (GO:0045494)	3.90393295
15	regulation of hippo signaling (GO:0035330)	3.85392998
16	detection of light stimulus involved in visual perception (GO:0050908)	3.82158364
17	detection of light stimulus involved in sensory perception (GO:0050962)	3.82158364
18	reflex (GO:0060004)	3.81047849
19	establishment of protein localization to Golgi (GO:0072600)	3.73289984
20	synapsis (GO:0007129)	3.63925635
21	protein K63-linked deubiquitination (GO:0070536)	3.59337901
22	DNA methylation involved in gamete generation (GO:0043046)	3.53209836
23	cellular ketone body metabolic process (GO:0046950)	3.51955833
24	cellular biogenic amine catabolic process (GO:0042402)	3.49352694
25	amine catabolic process (GO:0009310)	3.49352694
26	regulation of establishment of cell polarity (GO:2000114)	3.48157009
27	regulation of sarcomere organization (GO:0060297)	3.46806052
28	indole-containing compound metabolic process (GO:0042430)	3.43132218
29	behavioral response to nicotine (GO:0035095)	3.38491928
30	benzene-containing compound metabolic process (GO:0042537)	3.34344300
31	L-fucose catabolic process (GO:0042355)	3.33523403
32	fucose catabolic process (GO:0019317)	3.33523403
33	L-fucose metabolic process (GO:0042354)	3.33523403
34	tachykinin receptor signaling pathway (GO:0007217)	3.33040326
35	retinal cone cell development (GO:0046549)	3.32324113
36	auditory receptor cell stereocilium organization (GO:0060088)	3.29901132
37	sex differentiation (GO:0007548)	3.29879927
38	monoubiquitinated protein deubiquitination (GO:0035520)	3.25897427
39	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.24813552
40	NAD biosynthetic process (GO:0009435)	3.20350278
41	sulfation (GO:0051923)	3.20238530
42	thyroid hormone metabolic process (GO:0042403)	3.20160044
43	aromatic amino acid family catabolic process (GO:0009074)	3.20060526
44	ketone body metabolic process (GO:1902224)	3.16928680
45	lipid translocation (GO:0034204)	3.16412164
46	phospholipid translocation (GO:0045332)	3.16412164
47	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.13090407
48	serotonin receptor signaling pathway (GO:0007210)	3.12962016
49	DNA double-strand break processing (GO:0000729)	3.08711413
50	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.07849798
51	male meiosis (GO:0007140)	3.07125661
52	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.06954859
53	regulation of posttranscriptional gene silencing (GO:0060147)	3.04601806
54	regulation of gene silencing by miRNA (GO:0060964)	3.04601806
55	regulation of gene silencing by RNA (GO:0060966)	3.04601806
56	righting reflex (GO:0060013)	3.01764736
57	reciprocal DNA recombination (GO:0035825)	2.97812190
58	reciprocal meiotic recombination (GO:0007131)	2.97812190
59	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.97448139
60	cellular response to sterol (GO:0036315)	2.95997975
61	male meiosis I (GO:0007141)	2.90873619
62	negative regulation of mast cell activation (GO:0033004)	2.88753373
63	aromatic amino acid family metabolic process (GO:0009072)	2.85341915
64	regulation of memory T cell differentiation (GO:0043380)	2.83910861
65	rRNA catabolic process (GO:0016075)	2.81277635
66	flavonoid metabolic process (GO:0009812)	2.81186319
67	behavioral response to ethanol (GO:0048149)	2.78556350
68	replication fork processing (GO:0031297)	2.78467980
69	regulation of collateral sprouting (GO:0048670)	2.74262450
70	gene silencing by RNA (GO:0031047)	2.71894093
71	axoneme assembly (GO:0035082)	2.71764252
72	cilium morphogenesis (GO:0060271)	2.69637005
73	inner ear receptor stereocilium organization (GO:0060122)	2.67586140
74	interkinetic nuclear migration (GO:0022027)	2.64784531
75	glycerophospholipid catabolic process (GO:0046475)	2.64450874
76	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.64284030
77	sperm motility (GO:0030317)	2.62420864
78	cilium organization (GO:0044782)	2.60618081
79	killing of cells of other organism (GO:0031640)	2.59642739
80	disruption of cells of other organism (GO:0044364)	2.59642739
81	protein targeting to Golgi (GO:0000042)	2.59267301
82	amino acid salvage (GO:0043102)	2.59130410
83	L-methionine salvage (GO:0071267)	2.59130410
84	L-methionine biosynthetic process (GO:0071265)	2.59130410
85	cilium assembly (GO:0042384)	2.58558702
86	gamma-aminobutyric acid transport (GO:0015812)	2.58358068
87	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.57389985
88	double-strand break repair via homologous recombination (GO:0000724)	2.54759219
89	startle response (GO:0001964)	2.54529547
90	primary amino compound metabolic process (GO:1901160)	2.54343135
91	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.53653393
92	recombinational repair (GO:0000725)	2.53241988
93	response to pheromone (GO:0019236)	2.53234717
94	positive regulation of developmental pigmentation (GO:0048087)	2.52443837
95	chromosome organization involved in meiosis (GO:0070192)	2.51846788
96	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.51763993
97	nonmotile primary cilium assembly (GO:0035058)	2.51656060
98	acrosome reaction (GO:0007340)	2.51367066
99	centriole replication (GO:0007099)	2.50616992
100	regulation of meiosis I (GO:0060631)	2.50039450

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.98344303
2	VDR_22108803_ChIP-Seq_LS180_Human	3.28103401
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.14872902
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.13570094
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.66747142
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.64259294
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.59324205
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.59045422
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.57479617
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.52120818
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.30755379
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.29831737
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.19175115
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.18618273
15	ER_23166858_ChIP-Seq_MCF-7_Human	2.18391479
16	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.12069205
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.10543542
18	P300_19829295_ChIP-Seq_ESCs_Human	2.08443141
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.07496829
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.05071686
21	FUS_26573619_Chip-Seq_HEK293_Human	2.04559899
22	EWS_26573619_Chip-Seq_HEK293_Human	2.00621628
23	STAT3_23295773_ChIP-Seq_U87_Human	1.94934270
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.89467195
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.86844747
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.83563266
27	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.82415035
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.81915250
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.80721822
30	TCF4_23295773_ChIP-Seq_U87_Human	1.75279911
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.66661171
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.66661171
33	AR_21572438_ChIP-Seq_LNCaP_Human	1.64133609
34	AR_25329375_ChIP-Seq_VCAP_Human	1.63981654
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.61537506
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.60594564
37	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.55685134
38	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.51780835
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.50324728
40	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.49485659
41	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.45159975
42	TCF4_22108803_ChIP-Seq_LS180_Human	1.42387025
43	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41664393
44	RUNX2_22187159_ChIP-Seq_PCA_Human	1.41646026
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41242759
46	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.38745840
47	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.38621812
48	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.36876853
49	DROSHA_22980978_ChIP-Seq_HELA_Human	1.36570643
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35188488
51	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33993278
52	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.33993278
53	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.32818757
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.32811874
55	CDX2_22108803_ChIP-Seq_LS180_Human	1.32327892
56	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.30972678
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.30459914
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.30070120
59	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.29660313
60	* TP53_22573176_ChIP-Seq_HFKS_Human	1.29622084
61	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29417053
62	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28931260
63	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.27922402
64	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.27731674
65	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.24007873
66	TP53_16413492_ChIP-PET_HCT116_Human	1.23232826
67	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.22758369
68	IRF1_19129219_ChIP-ChIP_H3396_Human	1.22599100
69	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.21377554
70	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.19133470
71	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18419996
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17786332
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17786332
74	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.15088890
75	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.14915696
76	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.14840677
77	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13764344
78	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.12493860
79	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09610594
80	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09610594
81	REST_21632747_ChIP-Seq_MESCs_Mouse	1.09582796
82	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.07332632
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.06529898
84	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.05783412
85	AHR_22903824_ChIP-Seq_MCF-7_Human	1.04650990
86	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.04324278
87	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.04114074
88	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.03345477
89	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02530914
90	RNF2_27304074_Chip-Seq_NSC_Mouse	1.01741942
91	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.01105836
92	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00967308
93	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.00881065
94	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.00647626
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00318442
96	TBL1_22424771_ChIP-Seq_293T_Human	0.99627284
97	P300_18555785_Chip-Seq_ESCs_Mouse	0.99066784
98	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.97107209
99	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.96006582
100	KDM2B_26808549_Chip-Seq_REH_Human	0.95935729

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.36977339
2	MP0003195_calcinosis	3.28743179
3	MP0005551_abnormal_eye_electrophysiolog	2.76857547
4	MP0008877_abnormal_DNA_methylation	2.71691201
5	MP0008057_abnormal_DNA_replication	2.62186684
6	MP0002736_abnormal_nociception_after	2.50440617
7	MP0001968_abnormal_touch/_nociception	2.47308381
8	MP0004043_abnormal_pH_regulation	2.46935927
9	MP0001501_abnormal_sleep_pattern	2.45236720
10	MP0009046_muscle_twitch	2.27067467
11	MP0001984_abnormal_olfaction	2.07871249
12	MP0003646_muscle_fatigue	2.07754571
13	MP0005670_abnormal_white_adipose	2.05020973
14	MP0002138_abnormal_hepatobiliary_system	1.97821847
15	MP0006276_abnormal_autonomic_nervous	1.88944133
16	MP0005646_abnormal_pituitary_gland	1.87260083
17	MP0000427_abnormal_hair_cycle	1.85059555
18	MP0000372_irregular_coat_pigmentation	1.83562397
19	MP0005410_abnormal_fertilization	1.79445904
20	MP0005253_abnormal_eye_physiology	1.78158004
21	MP0009745_abnormal_behavioral_response	1.77048093
22	MP0001486_abnormal_startle_reflex	1.60748902
23	MP0005310_abnormal_salivary_gland	1.60233351
24	MP0003252_abnormal_bile_duct	1.59160109
25	MP0003718_maternal_effect	1.49774222
26	MP0003183_abnormal_peptide_metabolism	1.48941415
27	MP0000383_abnormal_hair_follicle	1.48439132
28	MP0002876_abnormal_thyroid_physiology	1.48158445
29	MP0008872_abnormal_physiological_respon	1.47056009
30	MP0005167_abnormal_blood-brain_barrier	1.46472786
31	MP0002735_abnormal_chemical_nociception	1.44191928
32	MP0003698_abnormal_male_reproductive	1.41902617
33	MP0003136_yellow_coat_color	1.40267153
34	MP0002234_abnormal_pharynx_morphology	1.39524562
35	MP0008875_abnormal_xenobiotic_pharmacok	1.38797218
36	MP0003950_abnormal_plasma_membrane	1.37862799
37	MP0002102_abnormal_ear_morphology	1.37117879
38	MP0005645_abnormal_hypothalamus_physiol	1.36984049
39	MP0000631_abnormal_neuroendocrine_gland	1.36583327
40	MP0004147_increased_porphyrin_level	1.36553289
41	MP0010386_abnormal_urinary_bladder	1.34809265
42	MP0002272_abnormal_nervous_system	1.30772948
43	MP0003787_abnormal_imprinting	1.29147449
44	MP0005647_abnormal_sex_gland	1.27811349
45	MP0002837_dystrophic_cardiac_calcinosis	1.23748698
46	MP0006054_spinal_hemorrhage	1.22179865
47	MP0002064_seizures	1.21993910
48	MP0001929_abnormal_gametogenesis	1.21852782
49	MP0002572_abnormal_emotion/affect_behav	1.21110724
50	MP0001986_abnormal_taste_sensitivity	1.20476108
51	MP0009697_abnormal_copulation	1.19929012
52	MP0000230_abnormal_systemic_arterial	1.17260463
53	MP0005389_reproductive_system_phenotype	1.16340762
54	MP0004142_abnormal_muscle_tone	1.15855406
55	MP0001485_abnormal_pinna_reflex	1.15651291
56	MP0000371_diluted_coat_color	1.15122068
57	MP0008058_abnormal_DNA_repair	1.14176044
58	MP0002210_abnormal_sex_determination	1.14170541
59	MP0001764_abnormal_homeostasis	1.12450968
60	MP0004924_abnormal_behavior	1.11100187
61	MP0005386_behavior/neurological_phenoty	1.11100187
62	MP0005174_abnormal_tail_pigmentation	1.10652354
63	MP0002160_abnormal_reproductive_system	1.09226309
64	MP0003880_abnormal_central_pattern	1.09042474
65	MP0002557_abnormal_social/conspecific_i	1.08979559
66	MP0004215_abnormal_myocardial_fiber	1.07384009
67	MP0006072_abnormal_retinal_apoptosis	1.07062352
68	MP0001970_abnormal_pain_threshold	1.06954961
69	MP0005085_abnormal_gallbladder_physiolo	1.04553038
70	MP0002067_abnormal_sensory_capabilities	1.04328543
71	MP0008961_abnormal_basal_metabolism	1.03819188
72	MP0000653_abnormal_sex_gland	1.03475438
73	MP0002928_abnormal_bile_duct	1.03361568
74	MP0002938_white_spotting	0.99456884
75	MP0002229_neurodegeneration	0.98832189
76	MP0008995_early_reproductive_senescence	0.95538076
77	MP0005360_urolithiasis	0.94658592
78	MP0003045_fibrosis	0.94010980
79	MP0004085_abnormal_heartbeat	0.93894266
80	MP0001145_abnormal_male_reproductive	0.93362373
81	MP0004145_abnormal_muscle_electrophysio	0.92350207
82	MP0002733_abnormal_thermal_nociception	0.91560495
83	MP0001919_abnormal_reproductive_system	0.91425247
84	MP0006292_abnormal_olfactory_placode	0.90100146
85	MP0003137_abnormal_impulse_conducting	0.89664058
86	MP0003635_abnormal_synaptic_transmissio	0.88049779
87	MP0010329_abnormal_lipoprotein_level	0.87401721
88	MP0005377_hearing/vestibular/ear_phenot	0.86849544
89	MP0003878_abnormal_ear_physiology	0.86849544
90	MP0005395_other_phenotype	0.86192610
91	MP0002254_reproductive_system_inflammat	0.85520834
92	MP0000538_abnormal_urinary_bladder	0.84234888
93	MP0004742_abnormal_vestibular_system	0.83262170
94	MP0005195_abnormal_posterior_eye	0.82962568
95	MP0003633_abnormal_nervous_system	0.81158891
96	MP0010094_abnormal_chromosome_stability	0.80041976
97	MP0002638_abnormal_pupillary_reflex	0.79423761
98	MP0002095_abnormal_skin_pigmentation	0.79175521
99	MP0005266_abnormal_metabolism	0.78147395
100	MP0005075_abnormal_melanosome_morpholog	0.77060990

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.59578695
2	Genetic anticipation (HP:0003743)	4.03731285
3	Hyperventilation (HP:0002883)	4.02034068
4	Pancreatic fibrosis (HP:0100732)	4.01738032
5	True hermaphroditism (HP:0010459)	3.97192306
6	Attenuation of retinal blood vessels (HP:0007843)	3.93150272
7	Gaze-evoked nystagmus (HP:0000640)	3.84031027
8	Abnormality of the renal cortex (HP:0011035)	3.57194416
9	Molar tooth sign on MRI (HP:0002419)	3.53964257
10	Abnormality of midbrain morphology (HP:0002418)	3.53964257
11	Congenital stationary night blindness (HP:0007642)	3.44688448
12	Nephronophthisis (HP:0000090)	3.44316172
13	Progressive cerebellar ataxia (HP:0002073)	3.37421515
14	Chronic hepatic failure (HP:0100626)	3.36754420
15	Abnormality of the renal medulla (HP:0100957)	3.33256179
16	Congenital sensorineural hearing impairment (HP:0008527)	3.18700719
17	Bony spicule pigmentary retinopathy (HP:0007737)	3.11578501
18	Cystic liver disease (HP:0006706)	3.05904925
19	Abolished electroretinogram (ERG) (HP:0000550)	2.99740246
20	Medial flaring of the eyebrow (HP:0010747)	2.97522063
21	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.96674759
22	Absent speech (HP:0001344)	2.69998314
23	Type II lissencephaly (HP:0007260)	2.68712730
24	Protruding tongue (HP:0010808)	2.57882225
25	Tubular atrophy (HP:0000092)	2.57530541
26	Clumsiness (HP:0002312)	2.56974912
27	Fair hair (HP:0002286)	2.47665028
28	Increased corneal curvature (HP:0100692)	2.47191181
29	Keratoconus (HP:0000563)	2.47191181
30	Febrile seizures (HP:0002373)	2.44523128
31	Gait imbalance (HP:0002141)	2.42258698
32	Congenital primary aphakia (HP:0007707)	2.41809474
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.36869727
34	Abnormal drinking behavior (HP:0030082)	2.33898654
35	Polydipsia (HP:0001959)	2.33898654
36	Decreased circulating renin level (HP:0003351)	2.31031115
37	Cerebellar dysplasia (HP:0007033)	2.30706161
38	Pendular nystagmus (HP:0012043)	2.30229918
39	Nephrogenic diabetes insipidus (HP:0009806)	2.29846265
40	Generalized hypopigmentation of hair (HP:0011358)	2.28926035
41	Focal seizures (HP:0007359)	2.28717638
42	Dialeptic seizures (HP:0011146)	2.26851913
43	Renal cortical cysts (HP:0000803)	2.23400581
44	Congenital hepatic fibrosis (HP:0002612)	2.21250793
45	Inability to walk (HP:0002540)	2.21101199
46	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.19495823
47	Abnormality of alanine metabolism (HP:0010916)	2.19495823
48	Hyperalaninemia (HP:0003348)	2.19495823
49	Abnormal biliary tract physiology (HP:0012439)	2.17072114
50	Bile duct proliferation (HP:0001408)	2.17072114
51	Sclerocornea (HP:0000647)	2.16086892
52	Genital tract atresia (HP:0001827)	2.15334810
53	Central scotoma (HP:0000603)	2.14365867
54	Male pseudohermaphroditism (HP:0000037)	2.14151076
55	Decreased central vision (HP:0007663)	2.13467266
56	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.12843893
57	Widely spaced teeth (HP:0000687)	2.10688596
58	Tubulointerstitial nephritis (HP:0001970)	2.10500663
59	Absence seizures (HP:0002121)	2.10284899
60	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.08463792
61	Retinitis pigmentosa (HP:0000510)	2.05898590
62	Hyperglycinuria (HP:0003108)	2.05278116
63	Absent/shortened dynein arms (HP:0200106)	2.05181918
64	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.05181918
65	Furrowed tongue (HP:0000221)	2.03868594
66	Large for gestational age (HP:0001520)	2.03740262
67	Progressive inability to walk (HP:0002505)	2.02791133
68	Hypothermia (HP:0002045)	2.00436785
69	Abnormal rod and cone electroretinograms (HP:0008323)	1.99341170
70	Volvulus (HP:0002580)	1.99309900
71	Astigmatism (HP:0000483)	1.98998821
72	Vaginal atresia (HP:0000148)	1.98795995
73	Poor coordination (HP:0002370)	1.98032101
74	Postaxial foot polydactyly (HP:0001830)	1.96922622
75	Lissencephaly (HP:0001339)	1.94057300
76	Small hand (HP:0200055)	1.93633070
77	Broad-based gait (HP:0002136)	1.92295717
78	Intestinal atresia (HP:0011100)	1.92058521
79	Anencephaly (HP:0002323)	1.90197745
80	Polyuria (HP:0000103)	1.90007722
81	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.87616867
82	Abnormality of macular pigmentation (HP:0008002)	1.86613395
83	Abnormal ciliary motility (HP:0012262)	1.86132840
84	Sloping forehead (HP:0000340)	1.85788919
85	Hypoplastic ischia (HP:0003175)	1.85623410
86	Constricted visual fields (HP:0001133)	1.83800263
87	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.81559637
88	Oligodactyly (hands) (HP:0001180)	1.81160450
89	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.81096285
90	Tubulointerstitial abnormality (HP:0001969)	1.79746811
91	Ketosis (HP:0001946)	1.77969668
92	Highly arched eyebrow (HP:0002553)	1.76960687
93	Preaxial hand polydactyly (HP:0001177)	1.76580126
94	Short foot (HP:0001773)	1.75160230
95	Hyperglycinemia (HP:0002154)	1.73890002
96	Abnormality of the ischium (HP:0003174)	1.73809205
97	Retinal dysplasia (HP:0007973)	1.72326465
98	Abnormality of chromosome stability (HP:0003220)	1.72233827
99	Chromsome breakage (HP:0040012)	1.71828517
100	Abnormality of the ileum (HP:0001549)	1.71820800

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	9.88037267
2	WNK3	2.79245367
3	BMPR1B	2.73087940
4	ACVR1B	2.58820008
5	ADRBK2	2.29155422
6	PINK1	2.27621124
7	MAP4K2	2.07475310
8	MAPK13	2.01822128
9	NUAK1	1.93713612
10	INSRR	1.87067996
11	TAOK3	1.82436164
12	STK38L	1.80579730
13	GRK1	1.74916919
14	CASK	1.74362914
15	OXSR1	1.66867877
16	NTRK3	1.66573788
17	ZAK	1.61279729
18	MAP3K4	1.34943991
19	AKT3	1.33838371
20	MKNK2	1.32534243
21	FER	1.30938037
22	TXK	1.29764306
23	WNK4	1.20629753
24	TNK2	1.20520919
25	STK39	1.19159072
26	PIK3CG	1.07663958
27	MAPKAPK3	1.03232052
28	MAP3K7	0.98234662
29	PTK2B	0.94960137
30	STK3	0.93665358
31	ADRBK1	0.92486896
32	DAPK2	0.92045030
33	BCKDK	0.91468397
34	EIF2AK3	0.88374077
35	TEC	0.87930055
36	BRSK2	0.84751954
37	PAK3	0.81492925
38	PRKCE	0.80852111
39	TRIM28	0.80760682
40	BCR	0.80041623
41	MARK1	0.74973720
42	TGFBR1	0.74027548
43	PLK2	0.71568572
44	LATS1	0.69624757
45	TNIK	0.69566705
46	PRKAA2	0.68573342
47	STK38	0.67938992
48	PLK4	0.66576913
49	CDK19	0.65893960
50	MKNK1	0.62908598
51	PRKCG	0.62084183
52	PIK3CA	0.60993993
53	CAMK1G	0.58356164
54	PNCK	0.56985177
55	EPHA4	0.56654490
56	ERBB2	0.56032228
57	MAPKAPK5	0.55887264
58	TIE1	0.54012943
59	IRAK1	0.53230202
60	CSNK1G1	0.51672790
61	MAP2K6	0.51289647
62	TRPM7	0.51145676
63	PKN1	0.49853135
64	CAMK2A	0.49543698
65	PRKAA1	0.49223980
66	PDK2	0.48955516
67	MAP2K7	0.48696091
68	FLT3	0.48194176
69	CAMKK2	0.47101698
70	CAMK1	0.45208043
71	ERBB3	0.43393877
72	CDK3	0.42565216
73	FGFR2	0.41527163
74	CSNK1A1L	0.41486936
75	CSNK1G2	0.40736717
76	CHEK2	0.39823399
77	EPHA3	0.39641759
78	MARK3	0.39201818
79	CCNB1	0.38511190
80	PRKG1	0.37868145
81	ATM	0.37591171
82	CSNK1A1	0.36007374
83	MST4	0.35686255
84	PRKCZ	0.34489791
85	MUSK	0.34319980
86	BLK	0.34202323
87	SGK2	0.34155538
88	CSNK1D	0.33971310
89	PRKACA	0.33547169
90	ATR	0.33475123
91	NME1	0.33172948
92	NLK	0.32996625
93	NEK2	0.31383827
94	PRKACB	0.31171805
95	CSNK1G3	0.30180915
96	OBSCN	0.29608578
97	CAMK1D	0.29315332
98	CHUK	0.28793389
99	IGF1R	0.28285299
100	DYRK2	0.26829603

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	3.21606385
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.59811356
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.51223860
4	Phototransduction_Homo sapiens_hsa04744	2.45791533
5	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.44598699
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.34691511
7	Tryptophan metabolism_Homo sapiens_hsa00380	2.33108972
8	Propanoate metabolism_Homo sapiens_hsa00640	2.32288963
9	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.30701408
10	ABC transporters_Homo sapiens_hsa02010	2.26426216
11	Homologous recombination_Homo sapiens_hsa03440	2.18583671
12	Selenocompound metabolism_Homo sapiens_hsa00450	2.11989343
13	Nitrogen metabolism_Homo sapiens_hsa00910	2.11298760
14	Nicotine addiction_Homo sapiens_hsa05033	2.09777540
15	Ether lipid metabolism_Homo sapiens_hsa00565	2.00361727
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.97124713
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.95354243
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.93932099
19	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.92353321
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.86586393
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.79108084
22	Olfactory transduction_Homo sapiens_hsa04740	1.75611878
23	Taste transduction_Homo sapiens_hsa04742	1.58206735
24	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.54755366
25	Non-homologous end-joining_Homo sapiens_hsa03450	1.49114429
26	Retinol metabolism_Homo sapiens_hsa00830	1.42491447
27	Glycerolipid metabolism_Homo sapiens_hsa00561	1.37944716
28	Morphine addiction_Homo sapiens_hsa05032	1.32475991
29	Chemical carcinogenesis_Homo sapiens_hsa05204	1.29172930
30	Serotonergic synapse_Homo sapiens_hsa04726	1.26988785
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.26078035
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.22874983
33	Salivary secretion_Homo sapiens_hsa04970	1.19826628
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.19084723
35	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.15920373
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.13276537
37	Histidine metabolism_Homo sapiens_hsa00340	1.11880668
38	Lysine degradation_Homo sapiens_hsa00310	1.10195331
39	Fatty acid degradation_Homo sapiens_hsa00071	1.09923221
40	Calcium signaling pathway_Homo sapiens_hsa04020	1.08072526
41	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.06986294
42	Caffeine metabolism_Homo sapiens_hsa00232	1.04136826
43	Circadian entrainment_Homo sapiens_hsa04713	1.03574527
44	beta-Alanine metabolism_Homo sapiens_hsa00410	1.02990431
45	Glutamatergic synapse_Homo sapiens_hsa04724	1.01080221
46	Basal transcription factors_Homo sapiens_hsa03022	1.00729501
47	Fatty acid metabolism_Homo sapiens_hsa01212	1.00251121
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.99549805
49	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.98993508
50	GABAergic synapse_Homo sapiens_hsa04727	0.96910352
51	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.96823581
52	Peroxisome_Homo sapiens_hsa04146	0.93238601
53	RNA polymerase_Homo sapiens_hsa03020	0.91640982
54	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.88464670
55	Regulation of autophagy_Homo sapiens_hsa04140	0.88359372
56	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.86984354
57	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.86804193
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.86016241
59	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.84949746
60	One carbon pool by folate_Homo sapiens_hsa00670	0.84075996
61	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.81290425
62	Insulin secretion_Homo sapiens_hsa04911	0.80829212
63	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.77051897
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.76210684
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.72579390
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.72163372
67	Circadian rhythm_Homo sapiens_hsa04710	0.70767368
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69630796
69	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.68731908
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66651816
71	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.65575946
72	Long-term depression_Homo sapiens_hsa04730	0.63778031
73	Sphingolipid metabolism_Homo sapiens_hsa00600	0.59504993
74	cAMP signaling pathway_Homo sapiens_hsa04024	0.59138071
75	Purine metabolism_Homo sapiens_hsa00230	0.57217471
76	Metabolic pathways_Homo sapiens_hsa01100	0.53701944
77	Glutathione metabolism_Homo sapiens_hsa00480	0.53675731
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.53272951
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.50791953
80	RNA degradation_Homo sapiens_hsa03018	0.50221589
81	Gastric acid secretion_Homo sapiens_hsa04971	0.50023824
82	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.49668208
83	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.49402920
84	Cholinergic synapse_Homo sapiens_hsa04725	0.44159084
85	Dopaminergic synapse_Homo sapiens_hsa04728	0.38462797
86	Renin secretion_Homo sapiens_hsa04924	0.37994150
87	Pancreatic secretion_Homo sapiens_hsa04972	0.37400919
88	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.35932591
89	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.35192281
90	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.34838236
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.33587175
92	Sulfur relay system_Homo sapiens_hsa04122	0.31594336
93	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.31204558
94	Mineral absorption_Homo sapiens_hsa04978	0.30720873
95	PPAR signaling pathway_Homo sapiens_hsa03320	0.29866492
96	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.28593139
97	Protein export_Homo sapiens_hsa03060	0.28467680
98	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.27887056
99	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.25809840
100	Platelet activation_Homo sapiens_hsa04611	0.24992782

POTEC

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »