POTED

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to Golgi (GO:0072600)9.81027165
2retrograde transport, vesicle recycling within Golgi (GO:0000301)9.30335297
3acrosome reaction (GO:0007340)8.79007722
4protein polyglutamylation (GO:0018095)8.11664772
5protein localization to Golgi apparatus (GO:0034067)7.41786787
6spermatid development (GO:0007286)7.38072306
7microtubule depolymerization (GO:0007019)6.95229445
8multicellular organism reproduction (GO:0032504)6.94414748
9fusion of sperm to egg plasma membrane (GO:0007342)6.46040111
10protein-chromophore linkage (GO:0018298)6.31634130
11sperm-egg recognition (GO:0035036)5.87232693
12microtubule polymerization or depolymerization (GO:0031109)5.75150830
13sperm capacitation (GO:0048240)5.72448057
14cilium or flagellum-dependent cell motility (GO:0001539)5.72379155
15axonemal dynein complex assembly (GO:0070286)5.71342483
16microtubule nucleation (GO:0007020)5.52960544
17chromosome condensation (GO:0030261)5.52389948
18reproduction (GO:0000003)5.51849343
19DNA packaging (GO:0006323)5.45280371
20binding of sperm to zona pellucida (GO:0007339)5.42415166
21epithelial cilium movement (GO:0003351)5.41199082
22motile cilium assembly (GO:0044458)5.35668927
23phosphatidylethanolamine biosynthetic process (GO:0006646)5.19293694
24negative regulation of inclusion body assembly (GO:0090084)5.11584529
25spermatogenesis (GO:0007283)5.06293789
26male gamete generation (GO:0048232)5.04750664
27male meiosis (GO:0007140)5.03676770
28plasma membrane fusion (GO:0045026)4.99935237
29single fertilization (GO:0007338)4.87213318
30cell-cell recognition (GO:0009988)4.86364931
31phosphatidylethanolamine metabolic process (GO:0046337)4.78438635
32synapsis (GO:0007129)4.75993990
33gamete generation (GO:0007276)4.69273047
34receptor recycling (GO:0001881)4.65047590
35centriole replication (GO:0007099)4.63420983
36early endosome to late endosome transport (GO:0045022)4.63418398
37calcium ion-dependent exocytosis (GO:0017156)4.59290347
38centriole assembly (GO:0098534)4.49978147
39cilium movement (GO:0003341)4.46688591
40phosphorylated carbohydrate dephosphorylation (GO:0046838)4.40367334
41inositol phosphate dephosphorylation (GO:0046855)4.40367334
42piRNA metabolic process (GO:0034587)4.39587491
43regulation of cilium movement (GO:0003352)4.32673702
44single strand break repair (GO:0000012)4.32366855
45polyamine biosynthetic process (GO:0006596)4.26705467
46fertilization (GO:0009566)4.24830216
47intra-Golgi vesicle-mediated transport (GO:0006891)4.23608569
48germ cell development (GO:0007281)4.13024400
49chromosome organization involved in meiosis (GO:0070192)4.06009616
50vitamin transmembrane transport (GO:0035461)3.99714076
51inositol phosphate catabolic process (GO:0071545)3.96859317
52regulation of centriole replication (GO:0046599)3.84842533
53alanine transport (GO:0032328)3.81033678
54multicellular organismal reproductive process (GO:0048609)3.80914105
55spermatid nucleus differentiation (GO:0007289)3.78572537
56rRNA methylation (GO:0031167)3.77387338
57regulation of phosphoprotein phosphatase activity (GO:0043666)3.76990652
58organic cation transport (GO:0015695)3.73788821
59microtubule severing (GO:0051013)3.72796420
60artery development (GO:0060840)3.67786997
61DNA methylation involved in gamete generation (GO:0043046)3.66468694
62cellular process involved in reproduction in multicellular organism (GO:0022412)3.66138273
63axoneme assembly (GO:0035082)3.63863290
64cullin deneddylation (GO:0010388)3.62679958
65cellular ketone body metabolic process (GO:0046950)3.62503172
66RNA destabilization (GO:0050779)3.48398748
67phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.41798175
68histone H3-K9 demethylation (GO:0033169)3.40667272
69male meiosis I (GO:0007141)3.38211372
70cell wall macromolecule catabolic process (GO:0016998)3.36723512
71male sex determination (GO:0030238)3.35323258
72regulation of microtubule-based movement (GO:0060632)3.34920261
73rhodopsin mediated signaling pathway (GO:0016056)3.34865391
74response to misfolded protein (GO:0051788)3.34712517
75seminiferous tubule development (GO:0072520)3.33873953
76regulation of vesicle fusion (GO:0031338)3.33797388
77meiotic nuclear division (GO:0007126)3.28566930
78proline transport (GO:0015824)3.27235255
79inositol metabolic process (GO:0006020)3.25842084
80cell wall macromolecule metabolic process (GO:0044036)3.23027006
81synaptonemal complex assembly (GO:0007130)3.22765308
82photoreceptor cell maintenance (GO:0045494)3.19318334
83ketone body metabolic process (GO:1902224)3.18351885
84nucleosome disassembly (GO:0006337)3.18044583
85protein-DNA complex disassembly (GO:0032986)3.18044583
86endosome organization (GO:0007032)3.17100576
87cellular biogenic amine biosynthetic process (GO:0042401)3.16037230
88peptidyl-glutamic acid modification (GO:0018200)3.10578899
89positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.10280709
90mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.10280709
91regulation of inclusion body assembly (GO:0090083)3.10174894
92detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.09762116
93platelet dense granule organization (GO:0060155)3.08149604
94protein deneddylation (GO:0000338)3.07350696
95retinol metabolic process (GO:0042572)3.06810185
96left/right axis specification (GO:0070986)3.05622183
97rRNA modification (GO:0000154)3.04614574
98righting reflex (GO:0060013)3.03591756
99sperm motility (GO:0030317)10.2240979
100protein targeting to Golgi (GO:0000042)10.0880102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.50010766
2IGF1R_20145208_ChIP-Seq_DFB_Human3.56479550
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.47077476
4EZH2_22144423_ChIP-Seq_EOC_Human3.36074688
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.21598494
6FUS_26573619_Chip-Seq_HEK293_Human3.00701580
7VDR_22108803_ChIP-Seq_LS180_Human2.92868941
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.75427981
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.41942280
10* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.35504756
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.26082620
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25323997
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.25323997
14AR_21572438_ChIP-Seq_LNCaP_Human2.22131812
15ER_23166858_ChIP-Seq_MCF-7_Human2.12512393
16GBX2_23144817_ChIP-Seq_PC3_Human2.04517493
17SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.98874337
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93366755
19ARNT_22903824_ChIP-Seq_MCF-7_Human1.91644703
20VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.90516771
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88699371
22* P300_19829295_ChIP-Seq_ESCs_Human1.81408355
23CBP_20019798_ChIP-Seq_JUKART_Human1.77059709
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.77059709
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74739845
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71852968
27NANOG_19829295_ChIP-Seq_ESCs_Human1.62609086
28SOX2_19829295_ChIP-Seq_ESCs_Human1.62609086
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60276355
30ERA_21632823_ChIP-Seq_H3396_Human1.59393704
31STAT3_23295773_ChIP-Seq_U87_Human1.55705693
32* SMAD4_21741376_ChIP-Seq_EPCs_Human1.53713296
33* SMAD3_21741376_ChIP-Seq_EPCs_Human1.53550691
34MYC_19829295_ChIP-Seq_ESCs_Human1.50102919
35RAC3_21632823_ChIP-Seq_H3396_Human1.48145007
36OCT4_20526341_ChIP-Seq_ESCs_Human1.47990522
37ZNF274_21170338_ChIP-Seq_K562_Hela1.46959303
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45995957
39ERG_20517297_ChIP-Seq_VCAP_Human1.45660603
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45606252
41* PRDM14_20953172_ChIP-Seq_ESCs_Human1.44708595
42RUNX2_22187159_ChIP-Seq_PCA_Human1.43515990
43* AR_25329375_ChIP-Seq_VCAP_Human1.43071571
44AUTS2_25519132_ChIP-Seq_293T-REX_Human1.40690116
45SMAD4_21799915_ChIP-Seq_A2780_Human1.40426159
46NANOG_20526341_ChIP-Seq_ESCs_Human1.40064293
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36511631
48EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.31265220
49DROSHA_22980978_ChIP-Seq_HELA_Human1.30561843
50AHR_22903824_ChIP-Seq_MCF-7_Human1.29761735
51PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.26883359
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26534155
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25835645
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25514194
55RBPJ_21746931_ChIP-Seq_IB4_Human1.24749581
56ETV1_20927104_ChIP-Seq_GIST48_Human1.24485213
57CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.22632468
58TP53_18474530_ChIP-ChIP_U2OS_Human1.22167436
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.21516659
60WDR5_24793694_ChIP-Seq_LNCAP_Human1.19515800
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19199288
62TBL1_22424771_ChIP-Seq_293T_Human1.18988656
63CBX2_22325352_ChIP-Seq_293T-Rex_Human1.18254208
64* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18081483
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16401071
66HNFA_21074721_ChIP-Seq_CACO-2_Human1.16332672
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.16048081
68PHF8_20622853_ChIP-Seq_HELA_Human1.15999865
69TCF4_23295773_ChIP-Seq_U87_Human1.14673498
70NFYB_21822215_ChIP-Seq_K562_Human1.11989451
71SMAD3_21741376_ChIP-Seq_ESCs_Human1.10382682
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10373405
73TAF2_19829295_ChIP-Seq_ESCs_Human1.08799752
74GATA6_21074721_ChIP-Seq_CACO-2_Human1.08590142
75TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.07455128
76REST_21632747_ChIP-Seq_MESCs_Mouse1.07186672
77PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07066377
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06451723
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06183996
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04790758
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.04393194
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04393194
83PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03426929
84CTCF_27219007_Chip-Seq_Bcells_Human1.03413739
85GATA3_21878914_ChIP-Seq_MCF-7_Human1.03399822
86PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03035310
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01974099
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01941294
89NFYA_21822215_ChIP-Seq_K562_Human1.01548713
90SMAD4_21741376_ChIP-Seq_HESCs_Human0.99465853
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99106392
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98752561
93TCF4_22108803_ChIP-Seq_LS180_Human0.98399554
94EZH2_27294783_Chip-Seq_ESCs_Mouse0.98282094
95* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97796431
96CTCF_20526341_ChIP-Seq_ESCs_Human0.97578455
97SMC4_20622854_ChIP-Seq_HELA_Human0.97265645
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96831132
99IRF1_19129219_ChIP-ChIP_H3396_Human0.96569354
100SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94822367

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation7.55689875
2MP0005410_abnormal_fertilization7.37381167
3MP0005083_abnormal_biliary_tract6.63509694
4MP0002638_abnormal_pupillary_reflex4.44209791
5MP0005084_abnormal_gallbladder_morpholo3.56729141
6MP0005085_abnormal_gallbladder_physiolo3.33476977
7MP0003698_abnormal_male_reproductive3.04687191
8MP0005670_abnormal_white_adipose2.84617264
9MP0005377_hearing/vestibular/ear_phenot2.80889033
10MP0003878_abnormal_ear_physiology2.80889033
11MP0005365_abnormal_bile_salt2.80791300
12MP0001929_abnormal_gametogenesis2.76389290
13MP0005253_abnormal_eye_physiology2.75831234
14MP0006072_abnormal_retinal_apoptosis2.57881061
15MP0002928_abnormal_bile_duct2.55830328
16MP0005551_abnormal_eye_electrophysiolog1.94822383
17MP0002160_abnormal_reproductive_system1.93996490
18MP0005379_endocrine/exocrine_gland_phen1.93996298
19MP0002138_abnormal_hepatobiliary_system1.87510948
20MP0001764_abnormal_homeostasis1.76292558
21MP0003718_maternal_effect1.75536195
22MP0004859_abnormal_synaptic_plasticity1.67134407
23MP0002210_abnormal_sex_determination1.64231621
24MP0002161_abnormal_fertility/fecundity1.57840819
25MP0003646_muscle_fatigue1.54440456
26MP0001905_abnormal_dopamine_level1.47964232
27MP0003879_abnormal_hair_cell1.41733623
28MP0010386_abnormal_urinary_bladder1.38586318
29MP0001145_abnormal_male_reproductive1.28290302
30MP0000653_abnormal_sex_gland1.24633082
31MP0001501_abnormal_sleep_pattern1.15493061
32MP0001502_abnormal_circadian_rhythm1.14727536
33MP0001968_abnormal_touch/_nociception1.11698222
34MP0008877_abnormal_DNA_methylation1.10540775
35MP0001485_abnormal_pinna_reflex1.10234555
36MP0005167_abnormal_blood-brain_barrier1.08752778
37MP0005310_abnormal_salivary_gland1.04071319
38MP0001486_abnormal_startle_reflex1.01988289
39MP0005391_vision/eye_phenotype1.00651559
40MP0003943_abnormal_hepatobiliary_system0.99595973
41MP0001529_abnormal_vocalization0.99396823
42MP0002735_abnormal_chemical_nociception0.98240635
43MP0000569_abnormal_digit_pigmentation0.97922583
44MP0009046_muscle_twitch0.96821649
45MP0005389_reproductive_system_phenotype0.95129384
46MP0000230_abnormal_systemic_arterial0.95075144
47MP0004742_abnormal_vestibular_system0.93666422
48MP0004043_abnormal_pH_regulation0.93447511
49MP0005647_abnormal_sex_gland0.93208191
50MP0005595_abnormal_vascular_smooth0.92959658
51MP0001765_abnormal_ion_homeostasis0.89583127
52MP0003315_abnormal_perineum_morphology0.86849563
53MP0001963_abnormal_hearing_physiology0.85987305
54MP0002736_abnormal_nociception_after0.85254987
55MP0002572_abnormal_emotion/affect_behav0.84528248
56MP0008004_abnormal_stomach_pH0.83592588
57MP0005395_other_phenotype0.81033753
58MP0003136_yellow_coat_color0.80315595
59MP0005451_abnormal_body_composition0.79825780
60MP0002229_neurodegeneration0.77225022
61MP0008058_abnormal_DNA_repair0.75790362
62MP0003045_fibrosis0.75487117
63MP0001545_abnormal_hematopoietic_system0.75116664
64MP0005397_hematopoietic_system_phenotyp0.75116664
65MP0004019_abnormal_vitamin_homeostasis0.74932730
66MP0008995_early_reproductive_senescence0.74493549
67MP0000538_abnormal_urinary_bladder0.73376795
68MP0002067_abnormal_sensory_capabilities0.71957971
69MP0002752_abnormal_somatic_nervous0.67680977
70MP0005360_urolithiasis0.67029472
71MP0002272_abnormal_nervous_system0.65914871
72MP0001664_abnormal_digestion0.65696977
73MP0005423_abnormal_somatic_nervous0.64827844
74MP0002234_abnormal_pharynx_morphology0.64745099
75MP0000026_abnormal_inner_ear0.63401816
76MP0008961_abnormal_basal_metabolism0.63165170
77MP0002282_abnormal_trachea_morphology0.62000742
78MP0001348_abnormal_lacrimal_gland0.61773490
79MP0002184_abnormal_innervation0.60767634
80MP0001440_abnormal_grooming_behavior0.60347183
81MP0008569_lethality_at_weaning0.57745236
82MP0003137_abnormal_impulse_conducting0.57555947
83MP0002557_abnormal_social/conspecific_i0.55656493
84MP0000955_abnormal_spinal_cord0.55020809
85MP0002733_abnormal_thermal_nociception0.54831926
86MP0009697_abnormal_copulation0.53082701
87MP0002132_abnormal_respiratory_system0.52579238
88MP0004264_abnormal_extraembryonic_tissu0.51324595
89MP0008775_abnormal_heart_ventricle0.48214140
90MP0001984_abnormal_olfaction0.47426751
91MP0009745_abnormal_behavioral_response0.47146402
92MP0006082_CNS_inflammation0.46249709
93MP0005666_abnormal_adipose_tissue0.44940347
94MP0003868_abnormal_feces_composition0.44146068
95MP0002932_abnormal_joint_morphology0.43692049
96MP0001666_abnormal_nutrient_absorption0.43631430
97MP0003693_abnormal_embryo_hatching0.41909348
98MP0000427_abnormal_hair_cycle0.40103893
99MP0003699_abnormal_female_reproductive0.39510445
100MP0005376_homeostasis/metabolism_phenot0.39451187

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)6.75398340
2Tubulointerstitial nephritis (HP:0001970)5.60329055
3Azoospermia (HP:0000027)5.26496310
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.22465134
5Absent/shortened dynein arms (HP:0200106)5.22465134
6Abnormal spermatogenesis (HP:0008669)4.83827560
7Resting tremor (HP:0002322)4.53545095
8Truncal obesity (HP:0001956)4.03137612
9Abnormal ciliary motility (HP:0012262)4.00519270
10Nephronophthisis (HP:0000090)3.97383819
11Postural instability (HP:0002172)3.95617378
12Abnormal respiratory motile cilium physiology (HP:0012261)3.91065382
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.87477690
14Abnormal respiratory epithelium morphology (HP:0012253)3.83947337
15Abnormal respiratory motile cilium morphology (HP:0005938)3.83947337
16Menstrual irregularities (HP:0000858)3.63267163
17Bile duct proliferation (HP:0001408)3.62167972
18Abnormal biliary tract physiology (HP:0012439)3.62167972
19Infertility (HP:0000789)3.45346767
20Broad face (HP:0000283)3.39086783
21Abnormality of macular pigmentation (HP:0008002)3.38397875
22Progressive sensorineural hearing impairment (HP:0000408)3.35033086
23Bony spicule pigmentary retinopathy (HP:0007737)3.31665166
24Pancreatic cysts (HP:0001737)3.30200116
25Cone-rod dystrophy (HP:0000548)3.25397124
26Attenuation of retinal blood vessels (HP:0007843)3.23485727
27Abnormality of the renal medulla (HP:0100957)3.21480929
28Severe visual impairment (HP:0001141)3.19832018
29Amelogenesis imperfecta (HP:0000705)3.18808481
30Hand muscle atrophy (HP:0009130)3.16861626
31Renovascular hypertension (HP:0100817)3.08651206
32Hypoalphalipoproteinemia (HP:0003233)3.04520448
33Hyperkalemia (HP:0002153)3.01800034
34Abnormality of the nasal mucosa (HP:0000433)3.01345250
35Nasal polyposis (HP:0100582)2.96121388
36Male infertility (HP:0003251)2.95629054
37Asymmetric septal hypertrophy (HP:0001670)2.88418800
38Amyotrophic lateral sclerosis (HP:0007354)2.82090471
39True hermaphroditism (HP:0010459)2.73813951
40Congenital stationary night blindness (HP:0007642)2.72558765
41Generalized aminoaciduria (HP:0002909)2.71795944
42Rhinitis (HP:0012384)2.71095161
43Abnormality of the lower motor neuron (HP:0002366)2.64080113
44Pancreatic fibrosis (HP:0100732)2.63295719
45Upper motor neuron abnormality (HP:0002127)2.58342066
46Portal hypertension (HP:0001409)2.56807324
47Tetraplegia (HP:0002445)2.56593698
48Stage 5 chronic kidney disease (HP:0003774)2.56067564
49Abnormal hair whorl (HP:0010721)2.52577993
50Abnormality of midbrain morphology (HP:0002418)2.48290027
51Molar tooth sign on MRI (HP:0002419)2.48290027
52Tubulointerstitial abnormality (HP:0001969)2.46106586
53Volvulus (HP:0002580)2.45376201
54Abnormality of the renal collecting system (HP:0004742)2.42997687
55Abnormality of the hepatic vasculature (HP:0006707)2.39610524
56Abnormality of the corticospinal tract (HP:0002492)2.37715388
57Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.35780514
58Abnormality of dental color (HP:0011073)2.34921107
59Abnormality of the renal cortex (HP:0011035)2.33116714
60Type II lissencephaly (HP:0007260)2.32489652
61Distal upper limb amyotrophy (HP:0007149)2.32246027
62Upper limb amyotrophy (HP:0009129)2.32246027
63Type II diabetes mellitus (HP:0005978)2.31175259
64Cystic liver disease (HP:0006706)2.30705154
65Duplicated collecting system (HP:0000081)2.30654628
66Photophobia (HP:0000613)2.26634023
67Myokymia (HP:0002411)2.22595941
68Abnormal sex determination (HP:0012244)2.20526434
69Sex reversal (HP:0012245)2.20526434
70Tubular atrophy (HP:0000092)2.19976717
71Subcapsular cataract (HP:0000523)2.18377274
72Progressive cerebellar ataxia (HP:0002073)2.16758144
73Insulin-resistant diabetes mellitus (HP:0000831)2.15429647
74Male pseudohermaphroditism (HP:0000037)2.15170674
75Congenital sensorineural hearing impairment (HP:0008527)2.13161975
76Chronic bronchitis (HP:0004469)2.10474087
77Atrophy/Degeneration involving motor neurons (HP:0007373)2.08917907
78Abnormality of DNA repair (HP:0003254)2.08195088
79Spastic tetraparesis (HP:0001285)2.07576023
80Enlarged epiphyses (HP:0010580)2.07042855
81Bradykinesia (HP:0002067)2.06899344
82Aplasia/Hypoplasia of the earlobes (HP:0009906)2.05302958
83Hypoplasia of the uterus (HP:0000013)1.99310340
84Optic nerve hypoplasia (HP:0000609)1.99263243
85Aplasia/Hypoplasia of the uvula (HP:0010293)1.98289398
86Anencephaly (HP:0002323)1.95727918
87Ectopic kidney (HP:0000086)1.93188353
88Polydipsia (HP:0001959)1.92968888
89Abnormal drinking behavior (HP:0030082)1.92968888
90Abnormality of the ileum (HP:0001549)1.90336550
91Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87738800
92Hypoplastic ischia (HP:0003175)1.87001722
93Hypergonadotropic hypogonadism (HP:0000815)1.86865946
94Impulsivity (HP:0100710)1.86522920
95Bronchiectasis (HP:0002110)1.86290876
96Cerebellar dysplasia (HP:0007033)1.85224929
97Absent thumb (HP:0009777)1.80967081
98Abnormality of ocular smooth pursuit (HP:0000617)1.79558575
99Inability to walk (HP:0002540)1.78103026
100Abnormality of the ischium (HP:0003174)1.76520293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME16.53088230
2PLK46.01605155
3PINK14.70969003
4BRD43.69549382
5PIK3CG2.85371344
6STK382.84092741
7STK38L2.68594370
8INSRR2.66351769
9TESK12.58360558
10PNCK2.51319648
11GRK12.22492341
12CAMK1G2.14175788
13PLK21.91295358
14FRK1.88566541
15PRKD31.86402401
16LATS11.77118660
17MARK31.63126993
18MAP3K91.59844773
19NEK61.44939978
20AKT31.41886619
21TLK11.40078320
22ADRBK21.30890295
23ARAF1.29229412
24MST1R1.28514916
25MAP3K41.27947601
26TIE11.22607384
27MAP4K21.22055474
28PTK2B1.18461682
29NEK21.16940769
30DDR21.13075776
31CAMK1D1.07422527
32PDPK10.99322903
33ZAK0.97616698
34PDK10.97233533
35TYRO30.96660249
36MAPK150.95868765
37BRAF0.93259624
38OXSR10.91874306
39RPS6KA50.83923616
40CDK120.82163043
41WNK40.81289238
42SIK20.79477371
43NTRK30.78660826
44ERBB30.77598694
45MAP2K70.72074141
46SGK2230.65777425
47SGK4940.65777425
48CAMK10.65564583
49STK390.64498159
50CDK30.63679705
51MYLK0.60677125
52PRKCQ0.57729887
53PBK0.54203580
54OBSCN0.52966359
55PRKG10.51031905
56BMPR1B0.49212131
57MARK10.49001079
58CDK10.47032746
59FGFR30.46317517
60WNK30.45914264
61AURKA0.44907950
62MAP3K20.43144884
63ROCK10.41900791
64WNK10.41152012
65MAPK130.37796651
66PRKAA20.35903146
67SGK10.35602835
68DAPK20.35462176
69PRKG20.35283200
70RPS6KA10.35026699
71SGK20.33902354
72GSK3B0.32411052
73PRKCG0.32378492
74MARK20.31981073
75PRKCB0.31112700
76MET0.30934290
77CDK50.30860342
78LIMK10.29612629
79MAP2K20.29527343
80PRKACB0.28785813
81NUAK10.28402699
82MAPK10.28263526
83NTRK20.27054290
84TESK20.26921728
85PRKACA0.26799382
86EIF2AK30.25674787
87PIM20.25665670
88RPS6KA20.25296604
89CAMK40.23507088
90CDK20.23334317
91RPS6KA60.23292493
92VRK10.21279591
93RPS6KB10.20587042
94DYRK1B0.20467035
95DYRK20.19751647
96MAPK140.19277992
97CHEK10.19065982
98TAOK30.18341610
99CSNK1A1L0.18013284
100ATM0.17993544

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.10313730
2Olfactory transduction_Homo sapiens_hsa047403.46966445
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.91632410
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.58296689
5Phototransduction_Homo sapiens_hsa047442.39728162
6Nitrogen metabolism_Homo sapiens_hsa009102.37113718
7Butanoate metabolism_Homo sapiens_hsa006502.19216324
8Retinol metabolism_Homo sapiens_hsa008302.12135818
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.07503435
10Inositol phosphate metabolism_Homo sapiens_hsa005622.03192955
11Fatty acid degradation_Homo sapiens_hsa000711.97859089
12Taste transduction_Homo sapiens_hsa047421.85936870
13Selenocompound metabolism_Homo sapiens_hsa004501.79487817
14Fatty acid metabolism_Homo sapiens_hsa012121.77696475
15Linoleic acid metabolism_Homo sapiens_hsa005911.72787801
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.71999056
17Glycerophospholipid metabolism_Homo sapiens_hsa005641.66517708
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.57653234
19PPAR signaling pathway_Homo sapiens_hsa033201.55346112
20Fanconi anemia pathway_Homo sapiens_hsa034601.55123875
21Dorso-ventral axis formation_Homo sapiens_hsa043201.54817896
22ABC transporters_Homo sapiens_hsa020101.52661730
23RNA transport_Homo sapiens_hsa030131.46218942
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45867244
25Chemical carcinogenesis_Homo sapiens_hsa052041.29697928
26Hedgehog signaling pathway_Homo sapiens_hsa043401.27748152
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26236481
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25737339
29Morphine addiction_Homo sapiens_hsa050321.24618434
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24596551
31Bile secretion_Homo sapiens_hsa049761.19083631
32Tryptophan metabolism_Homo sapiens_hsa003801.17511567
33Gap junction_Homo sapiens_hsa045401.17180496
34Glycerolipid metabolism_Homo sapiens_hsa005611.16268266
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13975428
36Arginine biosynthesis_Homo sapiens_hsa002201.11916621
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11264634
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10481879
39beta-Alanine metabolism_Homo sapiens_hsa004101.09662500
40Basal transcription factors_Homo sapiens_hsa030221.08790383
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06312509
42Nicotine addiction_Homo sapiens_hsa050331.04766136
43Calcium signaling pathway_Homo sapiens_hsa040201.03400224
44One carbon pool by folate_Homo sapiens_hsa006701.00175011
45Regulation of autophagy_Homo sapiens_hsa041400.99587282
46Arachidonic acid metabolism_Homo sapiens_hsa005900.98450217
47Fat digestion and absorption_Homo sapiens_hsa049750.98062126
48Oocyte meiosis_Homo sapiens_hsa041140.94044475
49Propanoate metabolism_Homo sapiens_hsa006400.92259181
50Arginine and proline metabolism_Homo sapiens_hsa003300.90480255
51Circadian entrainment_Homo sapiens_hsa047130.87878083
52Salivary secretion_Homo sapiens_hsa049700.85835864
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85644097
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85360182
55Vitamin digestion and absorption_Homo sapiens_hsa049770.85255788
56Histidine metabolism_Homo sapiens_hsa003400.83658253
57Non-homologous end-joining_Homo sapiens_hsa034500.81670859
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75153626
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.73745163
60Serotonergic synapse_Homo sapiens_hsa047260.72863216
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70147741
62Phenylalanine metabolism_Homo sapiens_hsa003600.69976338
63Lysine degradation_Homo sapiens_hsa003100.69901510
64Glutathione metabolism_Homo sapiens_hsa004800.68909757
65Glutamatergic synapse_Homo sapiens_hsa047240.66673369
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64187850
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63032186
68GABAergic synapse_Homo sapiens_hsa047270.62998624
69Type II diabetes mellitus_Homo sapiens_hsa049300.61873354
70Cardiac muscle contraction_Homo sapiens_hsa042600.59801357
71Systemic lupus erythematosus_Homo sapiens_hsa053220.55826137
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.54899619
73Circadian rhythm_Homo sapiens_hsa047100.54242041
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53839895
75Alcoholism_Homo sapiens_hsa050340.53771040
76Metabolic pathways_Homo sapiens_hsa011000.50596886
77Gastric acid secretion_Homo sapiens_hsa049710.48753716
78Ether lipid metabolism_Homo sapiens_hsa005650.47315265
79Sphingolipid metabolism_Homo sapiens_hsa006000.43275226
80Purine metabolism_Homo sapiens_hsa002300.43256838
81Renin secretion_Homo sapiens_hsa049240.42645625
82Cholinergic synapse_Homo sapiens_hsa047250.41772020
83cAMP signaling pathway_Homo sapiens_hsa040240.40843241
84mTOR signaling pathway_Homo sapiens_hsa041500.39999600
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39271565
86Pancreatic secretion_Homo sapiens_hsa049720.38837488
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38651926
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38518506
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37272788
90Huntingtons disease_Homo sapiens_hsa050160.36800530
91RNA degradation_Homo sapiens_hsa030180.36772218
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36648369
93Base excision repair_Homo sapiens_hsa034100.36166253
94Tyrosine metabolism_Homo sapiens_hsa003500.35081655
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31023243
96Insulin secretion_Homo sapiens_hsa049110.29358319
97Protein digestion and absorption_Homo sapiens_hsa049740.28508247
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27652106
99Oxytocin signaling pathway_Homo sapiens_hsa049210.24863356
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24358923

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »