

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | response to gravity (GO:0009629) | 7.17144725 |
| 2 | protein maturation by protein folding (GO:0022417) | 5.92206480 |
| 3 | detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580) | 5.61797102 |
| 4 | regulation of gonadotropin secretion (GO:0032276) | 5.12151844 |
| 5 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 4.87364665 |
| 6 | cullin deneddylation (GO:0010388) | 4.74487462 |
| 7 | galactose catabolic process (GO:0019388) | 4.70688760 |
| 8 | mannosylation (GO:0097502) | 4.62290343 |
| 9 | establishment of viral latency (GO:0019043) | 4.61267574 |
| 10 | detection of chemical stimulus involved in sensory perception of taste (GO:0050912) | 4.57456927 |
| 11 | response to interferon-beta (GO:0035456) | 4.46166070 |
| 12 | protein deneddylation (GO:0000338) | 4.41469648 |
| 13 | positive regulation of actin filament depolymerization (GO:0030836) | 4.37535334 |
| 14 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.35732947 |
| 15 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 4.33977059 |
| 16 | regulation of skeletal muscle contraction (GO:0014819) | 4.29290297 |
| 17 | protein complex biogenesis (GO:0070271) | 4.25814176 |
| 18 | proteasome assembly (GO:0043248) | 4.20942997 |
| 19 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.20337506 |
| 20 | establishment of integrated proviral latency (GO:0075713) | 4.17376645 |
| 21 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.14184095 |
| 22 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 4.12223666 |
| 23 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.12015871 |
| 24 | type B pancreatic cell proliferation (GO:0044342) | 4.10709740 |
| 25 | extracellular fibril organization (GO:0043206) | 4.10060185 |
| 26 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.09773791 |
| 27 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.03237360 |
| 28 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.03237360 |
| 29 | NADH dehydrogenase complex assembly (GO:0010257) | 4.03237360 |
| 30 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.93025591 |
| 31 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.93025591 |
| 32 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.90172697 |
| 33 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.90172697 |
| 34 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.90172697 |
| 35 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.82127137 |
| 36 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.81675433 |
| 37 | negative regulation of ligase activity (GO:0051352) | 3.81080825 |
| 38 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.81080825 |
| 39 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.80735805 |
| 40 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.77123113 |
| 41 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.77123113 |
| 42 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.64900740 |
| 43 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.47072807 |
| 44 | termination of RNA polymerase III transcription (GO:0006386) | 3.47072807 |
| 45 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.44927384 |
| 46 | cellular response to interferon-beta (GO:0035458) | 3.42515214 |
| 47 | DNA deamination (GO:0045006) | 3.40586894 |
| 48 | C-terminal protein lipidation (GO:0006501) | 3.40297805 |
| 49 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.36907598 |
| 50 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.34609691 |
| 51 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.34106610 |
| 52 | ATP synthesis coupled proton transport (GO:0015986) | 3.34106610 |
| 53 | xenobiotic catabolic process (GO:0042178) | 3.33213279 |
| 54 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.30896176 |
| 55 | GDP-mannose metabolic process (GO:0019673) | 3.25897334 |
| 56 | muscle cell migration (GO:0014812) | 3.23942780 |
| 57 | galactose metabolic process (GO:0006012) | 3.19409045 |
| 58 | actin filament depolymerization (GO:0030042) | 3.19098686 |
| 59 | sequestering of actin monomers (GO:0042989) | 3.17540233 |
| 60 | fibril organization (GO:0097435) | 3.16091277 |
| 61 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.15321391 |
| 62 | platelet dense granule organization (GO:0060155) | 3.12165983 |
| 63 | positive regulation of interleukin-8 secretion (GO:2000484) | 3.10693046 |
| 64 | positive regulation of ligase activity (GO:0051351) | 3.10028738 |
| 65 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.09123695 |
| 66 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.08654955 |
| 67 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.08654955 |
| 68 | C-terminal protein amino acid modification (GO:0018410) | 3.06989047 |
| 69 | COPI coating of Golgi vesicle (GO:0048205) | 3.06865013 |
| 70 | Golgi transport vesicle coating (GO:0048200) | 3.06865013 |
| 71 | morphogenesis of an endothelium (GO:0003159) | 3.04754406 |
| 72 | endothelial tube morphogenesis (GO:0061154) | 3.04754406 |
| 73 | * retina homeostasis (GO:0001895) | 3.00716408 |
| 74 | regulation of metalloenzyme activity (GO:0048552) | 2.99669893 |
| 75 | positive regulation of cell cycle arrest (GO:0071158) | 2.98357520 |
| 76 | positive regulation of growth hormone secretion (GO:0060124) | 2.97121985 |
| 77 | regulation of cellular amine metabolic process (GO:0033238) | 2.94907672 |
| 78 | negative regulation of JAK-STAT cascade (GO:0046426) | 2.94886330 |
| 79 | negative regulation of B cell apoptotic process (GO:0002903) | 2.93526882 |
| 80 | electron transport chain (GO:0022900) | 2.88953960 |
| 81 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.85648790 |
| 82 | response to testosterone (GO:0033574) | 2.84940065 |
| 83 | nucleoside transmembrane transport (GO:1901642) | 2.84468507 |
| 84 | adenosine metabolic process (GO:0046085) | 2.83891254 |
| 85 | respiratory electron transport chain (GO:0022904) | 2.83796006 |
| 86 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.83735576 |
| 87 | mitochondrial calcium ion homeostasis (GO:0051560) | 2.83519428 |
| 88 | nuclear envelope reassembly (GO:0031468) | 2.80579183 |
| 89 | mitotic nuclear envelope reassembly (GO:0007084) | 2.80579183 |
| 90 | AMP metabolic process (GO:0046033) | 2.80535766 |
| 91 | GTP biosynthetic process (GO:0006183) | 2.76059144 |
| 92 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.75736856 |
| 93 | spliceosomal snRNP assembly (GO:0000387) | 2.75023715 |
| 94 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G- | 2.74835236 |
| 95 | protein heterotetramerization (GO:0051290) | 2.71033431 |
| 96 | endothelial cell chemotaxis (GO:0035767) | 2.70542463 |
| 97 | signal transduction in response to DNA damage (GO:0042770) | 2.68719549 |
| 98 | lung secretory cell differentiation (GO:0061140) | 2.68291866 |
| 99 | regulation of interleukin-8 secretion (GO:2000482) | 2.68071447 |
| 100 | regulation of cell cycle arrest (GO:0071156) | 2.68052455 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.99226345 |
| 2 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 4.64107932 |
| 3 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 4.10738540 |
| 4 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.04565642 |
| 5 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.88129447 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.60520638 |
| 7 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.47922512 |
| 8 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.15886501 |
| 9 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.03332604 |
| 10 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.82521162 |
| 11 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.75882615 |
| 12 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.69666242 |
| 13 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.62318033 |
| 14 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.60864987 |
| 15 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 2.59372335 |
| 16 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.44673600 |
| 17 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.40820340 |
| 18 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 2.27617645 |
| 19 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.27523428 |
| 20 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.24094570 |
| 21 | VDR_22108803_ChIP-Seq_LS180_Human | 2.23462345 |
| 22 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.19258884 |
| 23 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.19100708 |
| 24 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.15285148 |
| 25 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.09875602 |
| 26 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 2.02310290 |
| 27 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.99807508 |
| 28 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.87841693 |
| 29 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.87106266 |
| 30 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.83774091 |
| 31 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.80447626 |
| 32 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.79724715 |
| 33 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.69591659 |
| 34 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.67129181 |
| 35 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.65363692 |
| 36 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.64678859 |
| 37 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.59421548 |
| 38 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.59229578 |
| 39 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.58795754 |
| 40 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.58472392 |
| 41 | CBP_21632823_ChIP-Seq_H3396_Human | 1.58008164 |
| 42 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.57136718 |
| 43 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.56264025 |
| 44 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.48132923 |
| 45 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.43417555 |
| 46 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.42880433 |
| 47 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.38093437 |
| 48 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.37533750 |
| 49 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.37450206 |
| 50 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.37046501 |
| 51 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28951114 |
| 52 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.27569924 |
| 53 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.25740623 |
| 54 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.22126940 |
| 55 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 1.20913325 |
| 56 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.20235929 |
| 57 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.20020726 |
| 58 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.19920261 |
| 59 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.18670401 |
| 60 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.18440747 |
| 61 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.17790904 |
| 62 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.16006602 |
| 63 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.16006602 |
| 64 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.15896976 |
| 65 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.15744791 |
| 66 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.15011735 |
| 67 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.14298603 |
| 68 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.13902436 |
| 69 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.13761464 |
| 70 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.12642085 |
| 71 | CTCF_20526341_ChIP-Seq_ESCs_Human | 1.12619540 |
| 72 | P300_27268052_Chip-Seq_Bcells_Human | 1.11980946 |
| 73 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.10879967 |
| 74 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.09835481 |
| 75 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.09330854 |
| 76 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.08451261 |
| 77 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.07424710 |
| 78 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.05862857 |
| 79 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.04222498 |
| 80 | AR_20517297_ChIP-Seq_VCAP_Human | 1.04094741 |
| 81 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.03654012 |
| 82 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.01837559 |
| 83 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.01174916 |
| 84 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.00838739 |
| 85 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.00467771 |
| 86 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.00449388 |
| 87 | ELF5_23300383_ChIP-Seq_T47D_Human | 1.00431973 |
| 88 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.00157227 |
| 89 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.99781916 |
| 90 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.98120025 |
| 91 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.97841692 |
| 92 | CJUN_26792858_Chip-Seq_BT549_Human | 0.97506523 |
| 93 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.95129562 |
| 94 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.94441798 |
| 95 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.94403821 |
| 96 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.94039769 |
| 97 | EOMES_21245162_ChIP-Seq_HESCs_Human | 0.93660552 |
| 98 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.93013802 |
| 99 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.91518392 |
| 100 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.91501563 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002163_abnormal_gland_morphology | 5.02488924 |
| 2 | MP0003806_abnormal_nucleotide_metabolis | 3.29226087 |
| 3 | MP0005379_endocrine/exocrine_gland_phen | 3.07652119 |
| 4 | MP0003191_abnormal_cellular_cholesterol | 3.00310491 |
| 5 | MP0005083_abnormal_biliary_tract | 2.85436252 |
| 6 | MP0002138_abnormal_hepatobiliary_system | 2.73972673 |
| 7 | MP0000749_muscle_degeneration | 2.73022792 |
| 8 | MP0003718_maternal_effect | 2.68829841 |
| 9 | MP0000613_abnormal_salivary_gland | 2.58808073 |
| 10 | MP0004510_myositis | 2.52506066 |
| 11 | MP0004147_increased_porphyrin_level | 2.48997492 |
| 12 | MP0000647_abnormal_sebaceous_gland | 2.30176796 |
| 13 | MP0006072_abnormal_retinal_apoptosis | 2.18923285 |
| 14 | MP0003786_premature_aging | 2.17726932 |
| 15 | MP0001542_abnormal_bone_strength | 2.17506617 |
| 16 | MP0005165_increased_susceptibility_to | 1.98626625 |
| 17 | MP0000751_myopathy | 1.97909737 |
| 18 | MP0001905_abnormal_dopamine_level | 1.92469920 |
| 19 | MP0010030_abnormal_orbit_morphology | 1.86503210 |
| 20 | MP0003315_abnormal_perineum_morphology | 1.81925573 |
| 21 | MP0006054_spinal_hemorrhage | 1.71572295 |
| 22 | MP0000750_abnormal_muscle_regeneration | 1.70561234 |
| 23 | MP0002006_tumorigenesis | 1.68728976 |
| 24 | MP0004043_abnormal_pH_regulation | 1.68084149 |
| 25 | MP0005084_abnormal_gallbladder_morpholo | 1.63618943 |
| 26 | MP0001243_abnormal_dermal_layer | 1.62001616 |
| 27 | MP0000747_muscle_weakness | 1.58350762 |
| 28 | MP0004145_abnormal_muscle_electrophysio | 1.56337015 |
| 29 | MP0005330_cardiomyopathy | 1.49823429 |
| 30 | MP0006035_abnormal_mitochondrial_morpho | 1.46536685 |
| 31 | MP0004272_abnormal_basement_membrane | 1.45276682 |
| 32 | MP0008775_abnormal_heart_ventricle | 1.40727046 |
| 33 | MP0002166_altered_tumor_susceptibility | 1.40692545 |
| 34 | MP0002822_catalepsy | 1.37630401 |
| 35 | MP0002332_abnormal_exercise_endurance | 1.28917299 |
| 36 | MP0008875_abnormal_xenobiotic_pharmacok | 1.27716823 |
| 37 | MP0003638_abnormal_response/metabolism_ | 1.27625100 |
| 38 | MP0000465_gastrointestinal_hemorrhage | 1.26248141 |
| 39 | MP0002106_abnormal_muscle_physiology | 1.26070446 |
| 40 | MP0003075_altered_response_to | 1.25740532 |
| 41 | MP0002736_abnormal_nociception_after | 1.23030713 |
| 42 | MP0000639_abnormal_adrenal_gland | 1.21233427 |
| 43 | MP0001968_abnormal_touch/_nociception | 1.13258821 |
| 44 | MP0005620_abnormal_muscle_contractility | 1.12256049 |
| 45 | MP0002282_abnormal_trachea_morphology | 1.10783238 |
| 46 | MP0002277_abnormal_respiratory_mucosa | 1.10147435 |
| 47 | MP0000372_irregular_coat_pigmentation | 1.07749338 |
| 48 | MP0000013_abnormal_adipose_tissue | 1.06982235 |
| 49 | MP0005410_abnormal_fertilization | 1.05451152 |
| 50 | MP0003011_delayed_dark_adaptation | 1.04879005 |
| 51 | MP0010386_abnormal_urinary_bladder | 1.04726225 |
| 52 | MP0005646_abnormal_pituitary_gland | 1.00570743 |
| 53 | MP0004142_abnormal_muscle_tone | 0.99416619 |
| 54 | MP0000358_abnormal_cell_content/ | 0.98600261 |
| 55 | MP0002837_dystrophic_cardiac_calcinosis | 0.98319549 |
| 56 | MP0003950_abnormal_plasma_membrane | 0.96444014 |
| 57 | MP0009780_abnormal_chondrocyte_physiolo | 0.96433674 |
| 58 | MP0005369_muscle_phenotype | 0.95471134 |
| 59 | MP0008872_abnormal_physiological_respon | 0.94865588 |
| 60 | MP0006036_abnormal_mitochondrial_physio | 0.94257749 |
| 61 | MP0009764_decreased_sensitivity_to | 0.91772869 |
| 62 | MP0001879_abnormal_lymphatic_vessel | 0.90217795 |
| 63 | MP0005257_abnormal_intraocular_pressure | 0.90206581 |
| 64 | MP0005253_abnormal_eye_physiology | 0.89601457 |
| 65 | MP0010368_abnormal_lymphatic_system | 0.89016482 |
| 66 | MP0008438_abnormal_cutaneous_collagen | 0.87895955 |
| 67 | MP0009046_muscle_twitch | 0.87826056 |
| 68 | MP0004134_abnormal_chest_morphology | 0.87151198 |
| 69 | MP0001756_abnormal_urination | 0.83405896 |
| 70 | MP0003866_abnormal_defecation | 0.82222423 |
| 71 | MP0001873_stomach_inflammation | 0.82134965 |
| 72 | MP0002876_abnormal_thyroid_physiology | 0.80577926 |
| 73 | MP0002210_abnormal_sex_determination | 0.80001134 |
| 74 | MP0005167_abnormal_blood-brain_barrier | 0.79807472 |
| 75 | MP0002733_abnormal_thermal_nociception | 0.79647780 |
| 76 | MP0003123_paternal_imprinting | 0.79276198 |
| 77 | MP0002148_abnormal_hypersensitivity_rea | 0.78984658 |
| 78 | MP0002653_abnormal_ependyma_morphology | 0.77264573 |
| 79 | MP0002735_abnormal_chemical_nociception | 0.76015377 |
| 80 | MP0002269_muscular_atrophy | 0.75849380 |
| 81 | MP0002972_abnormal_cardiac_muscle | 0.75279932 |
| 82 | MP0002089_abnormal_postnatal_growth/wei | 0.75265127 |
| 83 | MP0003880_abnormal_central_pattern | 0.73073216 |
| 84 | MP0002272_abnormal_nervous_system | 0.71735450 |
| 85 | MP0005367_renal/urinary_system_phenotyp | 0.71048092 |
| 86 | MP0000516_abnormal_urinary_system | 0.71048092 |
| 87 | MP0005395_other_phenotype | 0.70885553 |
| 88 | MP0005166_decreased_susceptibility_to | 0.67227174 |
| 89 | MP0002295_abnormal_pulmonary_circulatio | 0.66008008 |
| 90 | MP0008058_abnormal_DNA_repair | 0.65102879 |
| 91 | MP0002060_abnormal_skin_morphology | 0.64988847 |
| 92 | MP0005085_abnormal_gallbladder_physiolo | 0.63221632 |
| 93 | MP0001765_abnormal_ion_homeostasis | 0.59745959 |
| 94 | MP0000759_abnormal_skeletal_muscle | 0.59230931 |
| 95 | MP0000762_abnormal_tongue_morphology | 0.58561555 |
| 96 | MP0000230_abnormal_systemic_arterial | 0.58068118 |
| 97 | MP0001835_abnormal_antigen_presentation | 0.56811438 |
| 98 | MP0005670_abnormal_white_adipose | 0.56681288 |
| 99 | MP0005551_abnormal_eye_electrophysiolog | 0.56298211 |
| 100 | MP0001970_abnormal_pain_threshold | 0.54943459 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Hepatocellular necrosis (HP:0001404) | 4.38313486 |
| 2 | Congenital, generalized hypertrichosis (HP:0004540) | 4.26121416 |
| 3 | Palpebral edema (HP:0100540) | 4.06764203 |
| 4 | Hepatic necrosis (HP:0002605) | 4.02153498 |
| 5 | Adrenal hypoplasia (HP:0000835) | 3.95762954 |
| 6 | Acute necrotizing encephalopathy (HP:0006965) | 3.87309130 |
| 7 | Mitochondrial inheritance (HP:0001427) | 3.84489029 |
| 8 | Glucose intolerance (HP:0000833) | 3.74715150 |
| 9 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.57457181 |
| 10 | Reduced subcutaneous adipose tissue (HP:0003758) | 3.56448671 |
| 11 | Delayed CNS myelination (HP:0002188) | 3.39366393 |
| 12 | Type I transferrin isoform profile (HP:0003642) | 3.37956064 |
| 13 | Acute encephalopathy (HP:0006846) | 3.37598574 |
| 14 | Increased CSF lactate (HP:0002490) | 3.29518497 |
| 15 | Progressive macrocephaly (HP:0004481) | 3.04984089 |
| 16 | Palpitations (HP:0001962) | 2.89186496 |
| 17 | Reduced antithrombin III activity (HP:0001976) | 2.88300266 |
| 18 | Amyloidosis (HP:0011034) | 2.66990582 |
| 19 | Abnormal gallbladder physiology (HP:0012438) | 2.64332403 |
| 20 | Cholecystitis (HP:0001082) | 2.64332403 |
| 21 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.61417862 |
| 22 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.61417862 |
| 23 | Abnormal protein glycosylation (HP:0012346) | 2.61417862 |
| 24 | Abnormal glycosylation (HP:0012345) | 2.61417862 |
| 25 | Cerebral edema (HP:0002181) | 2.60679175 |
| 26 | Severe muscular hypotonia (HP:0006829) | 2.60037369 |
| 27 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.57489342 |
| 28 | Opisthotonus (HP:0002179) | 2.53451621 |
| 29 | Conjunctival hamartoma (HP:0100780) | 2.53399625 |
| 30 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.52929782 |
| 31 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.52929782 |
| 32 | Exercise intolerance (HP:0003546) | 2.49292784 |
| 33 | Abnormal glucose tolerance (HP:0001952) | 2.48200785 |
| 34 | Increased serum lactate (HP:0002151) | 2.47513383 |
| 35 | Lactic acidosis (HP:0003128) | 2.45950466 |
| 36 | Entropion (HP:0000621) | 2.40253529 |
| 37 | Large for gestational age (HP:0001520) | 2.40199306 |
| 38 | Sparse eyelashes (HP:0000653) | 2.39819745 |
| 39 | Abnormality of midbrain morphology (HP:0002418) | 2.39342760 |
| 40 | Molar tooth sign on MRI (HP:0002419) | 2.39342760 |
| 41 | Flat capital femoral epiphysis (HP:0003370) | 2.35161488 |
| 42 | Vacuolated lymphocytes (HP:0001922) | 2.33610633 |
| 43 | Microretrognathia (HP:0000308) | 2.32118130 |
| 44 | Insulin resistance (HP:0000855) | 2.28951289 |
| 45 | Abnormal spermatogenesis (HP:0008669) | 2.26897464 |
| 46 | Prolonged neonatal jaundice (HP:0006579) | 2.24978913 |
| 47 | J-shaped sella turcica (HP:0002680) | 2.23595727 |
| 48 | Facial edema (HP:0000282) | 2.23481601 |
| 49 | Increased hepatocellular lipid droplets (HP:0006565) | 2.22966960 |
| 50 | Methylmalonic aciduria (HP:0012120) | 2.22821203 |
| 51 | Insulin-resistant diabetes mellitus (HP:0000831) | 2.21002893 |
| 52 | Dysautonomia (HP:0002459) | 2.20399772 |
| 53 | Periorbital edema (HP:0100539) | 2.19567971 |
| 54 | Respiratory failure (HP:0002878) | 2.19424198 |
| 55 | Hypoplastic pelvis (HP:0008839) | 2.18640067 |
| 56 | Prostate neoplasm (HP:0100787) | 2.18286012 |
| 57 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.16875272 |
| 58 | Myoglobinuria (HP:0002913) | 2.10293108 |
| 59 | True hermaphroditism (HP:0010459) | 2.10245438 |
| 60 | Generalized aminoaciduria (HP:0002909) | 2.06355866 |
| 61 | Large eyes (HP:0001090) | 2.05652291 |
| 62 | Renal Fanconi syndrome (HP:0001994) | 2.05029480 |
| 63 | Pancreatic cysts (HP:0001737) | 2.03926658 |
| 64 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.03208154 |
| 65 | Microglossia (HP:0000171) | 2.02946745 |
| 66 | Abnormal number of erythroid precursors (HP:0012131) | 2.02838412 |
| 67 | Progressive microcephaly (HP:0000253) | 2.00798169 |
| 68 | Hypoplasia of the uterus (HP:0000013) | 2.00084736 |
| 69 | Increased serum pyruvate (HP:0003542) | 1.99512161 |
| 70 | Gliosis (HP:0002171) | 1.97558882 |
| 71 | Optic nerve coloboma (HP:0000588) | 1.96721848 |
| 72 | 3-Methylglutaconic aciduria (HP:0003535) | 1.94662264 |
| 73 | Short nail (HP:0001799) | 1.94458545 |
| 74 | Optic disc pallor (HP:0000543) | 1.92618514 |
| 75 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.92174852 |
| 76 | Pancreatic fibrosis (HP:0100732) | 1.90258900 |
| 77 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.89626965 |
| 78 | Lissencephaly (HP:0001339) | 1.89518556 |
| 79 | Limb-girdle muscle atrophy (HP:0003797) | 1.89231465 |
| 80 | Late onset (HP:0003584) | 1.88720811 |
| 81 | Hand muscle atrophy (HP:0009130) | 1.88194036 |
| 82 | Abnormality of glycolysis (HP:0004366) | 1.87397479 |
| 83 | Severe visual impairment (HP:0001141) | 1.86977667 |
| 84 | Abnormal autonomic nervous system physiology (HP:0012332) | 1.86966071 |
| 85 | Retinal dysplasia (HP:0007973) | 1.86884541 |
| 86 | Conjugated hyperbilirubinemia (HP:0002908) | 1.84524848 |
| 87 | Rough bone trabeculation (HP:0100670) | 1.83530343 |
| 88 | Erythema (HP:0010783) | 1.83129106 |
| 89 | Shoulder girdle muscle weakness (HP:0003547) | 1.83016536 |
| 90 | Increased intramyocellular lipid droplets (HP:0012240) | 1.82255792 |
| 91 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.81975528 |
| 92 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.81088669 |
| 93 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.81088669 |
| 94 | Bifid uvula (HP:0000193) | 1.80810794 |
| 95 | CNS demyelination (HP:0007305) | 1.80367564 |
| 96 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.80216215 |
| 97 | Lipid accumulation in hepatocytes (HP:0006561) | 1.79342941 |
| 98 | Ulnar deviation of the wrist (HP:0003049) | 1.78017663 |
| 99 | Bone cyst (HP:0012062) | 1.77144744 |
| 100 | Increased connective tissue (HP:0009025) | 1.76748551 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.96356411 |
| 2 | LMTK2 | 4.59325186 |
| 3 | TESK1 | 4.04913783 |
| 4 | NME2 | 3.98859255 |
| 5 | TESK2 | 3.62714527 |
| 6 | LIMK1 | 3.38962204 |
| 7 | TLK1 | 3.06997354 |
| 8 | PHKG2 | 2.69631838 |
| 9 | PHKG1 | 2.69631838 |
| 10 | BCKDK | 2.58343471 |
| 11 | EPHA2 | 2.55811577 |
| 12 | BUB1 | 2.52721094 |
| 13 | MST1R | 2.49627540 |
| 14 | VRK1 | 2.23717986 |
| 15 | ZAK | 2.07188030 |
| 16 | TAF1 | 2.00619362 |
| 17 | MAP2K7 | 2.00244977 |
| 18 | DAPK1 | 1.93488605 |
| 19 | MAP3K12 | 1.84891488 |
| 20 | TIE1 | 1.73664766 |
| 21 | ARAF | 1.61393588 |
| 22 | MST4 | 1.58901231 |
| 23 | CSNK1G3 | 1.54718295 |
| 24 | CSNK1A1L | 1.47446815 |
| 25 | MAPKAPK3 | 1.44322641 |
| 26 | NUAK1 | 1.38991589 |
| 27 | CSNK1G2 | 1.30588189 |
| 28 | PIM2 | 1.30220739 |
| 29 | MYLK | 1.29918847 |
| 30 | INSRR | 1.28878117 |
| 31 | CDK8 | 1.26555616 |
| 32 | NEK1 | 1.17754364 |
| 33 | CSNK1G1 | 1.11967330 |
| 34 | CCNB1 | 1.08786408 |
| 35 | DAPK2 | 1.08646712 |
| 36 | WNK4 | 1.04880173 |
| 37 | KDR | 0.98892891 |
| 38 | ERBB3 | 0.81734051 |
| 39 | AURKA | 0.77690258 |
| 40 | HIPK2 | 0.75929659 |
| 41 | TSSK6 | 0.75702013 |
| 42 | PTK2B | 0.75233193 |
| 43 | BCR | 0.72573685 |
| 44 | MAPKAPK5 | 0.72043241 |
| 45 | SCYL2 | 0.71720829 |
| 46 | MOS | 0.69825732 |
| 47 | OBSCN | 0.67727598 |
| 48 | GRK1 | 0.67136654 |
| 49 | DAPK3 | 0.65517528 |
| 50 | PAK4 | 0.65453306 |
| 51 | ABL2 | 0.64315390 |
| 52 | SRPK1 | 0.64091495 |
| 53 | STK16 | 0.64000176 |
| 54 | STK10 | 0.60457504 |
| 55 | WNK3 | 0.58876498 |
| 56 | RPS6KA5 | 0.57946919 |
| 57 | MAP4K2 | 0.53091509 |
| 58 | PDK2 | 0.50876007 |
| 59 | CAMK2G | 0.47078048 |
| 60 | ERBB4 | 0.46735780 |
| 61 | GRK5 | 0.46625648 |
| 62 | GRK7 | 0.46470421 |
| 63 | MAPK13 | 0.45157457 |
| 64 | MUSK | 0.45049561 |
| 65 | OXSR1 | 0.44517016 |
| 66 | BMPR1B | 0.44336655 |
| 67 | TRIM28 | 0.42330898 |
| 68 | CAMKK2 | 0.41723639 |
| 69 | FER | 0.40660569 |
| 70 | ILK | 0.39294357 |
| 71 | MET | 0.38195602 |
| 72 | DYRK2 | 0.36507443 |
| 73 | STK38 | 0.36228980 |
| 74 | MAP2K6 | 0.35723702 |
| 75 | EPHB2 | 0.35189576 |
| 76 | EIF2AK2 | 0.35019974 |
| 77 | ADRBK1 | 0.34448015 |
| 78 | PRKCI | 0.34316860 |
| 79 | TBK1 | 0.34199161 |
| 80 | TAOK2 | 0.33875702 |
| 81 | PINK1 | 0.33367086 |
| 82 | MAP3K4 | 0.32554389 |
| 83 | STK39 | 0.31685778 |
| 84 | CDK7 | 0.31582550 |
| 85 | BLK | 0.30547843 |
| 86 | BRSK1 | 0.28937945 |
| 87 | PAK1 | 0.26173322 |
| 88 | KIT | 0.24955299 |
| 89 | ADRBK2 | 0.24244710 |
| 90 | EPHB1 | 0.24118938 |
| 91 | PLK3 | 0.22848086 |
| 92 | SIK3 | 0.22726496 |
| 93 | SMG1 | 0.21447101 |
| 94 | IKBKE | 0.21281387 |
| 95 | BRAF | 0.19994742 |
| 96 | PRKACB | 0.19882834 |
| 97 | CDK19 | 0.19629093 |
| 98 | IRAK3 | 0.18218287 |
| 99 | CAMK2D | 0.17968342 |
| 100 | AURKB | 0.17907792 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.71894480 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.44579147 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 2.83439524 |
| 4 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.78755614 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.66571087 |
| 6 | Alzheimers disease_Homo sapiens_hsa05010 | 2.29888334 |
| 7 | Huntingtons disease_Homo sapiens_hsa05016 | 2.25389185 |
| 8 | DNA replication_Homo sapiens_hsa03030 | 2.23490921 |
| 9 | Base excision repair_Homo sapiens_hsa03410 | 2.23300343 |
| 10 | Folate biosynthesis_Homo sapiens_hsa00790 | 2.18838947 |
| 11 | Salivary secretion_Homo sapiens_hsa04970 | 2.01946643 |
| 12 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.96181940 |
| 13 | Asthma_Homo sapiens_hsa05310 | 1.88201068 |
| 14 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.79719713 |
| 15 | Mismatch repair_Homo sapiens_hsa03430 | 1.75244593 |
| 16 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.53948112 |
| 17 | Sulfur relay system_Homo sapiens_hsa04122 | 1.50400970 |
| 18 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.47956469 |
| 19 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.47663642 |
| 20 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.47283873 |
| 21 | Homologous recombination_Homo sapiens_hsa03440 | 1.46654247 |
| 22 | Protein export_Homo sapiens_hsa03060 | 1.45620446 |
| 23 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.43675502 |
| 24 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.42481501 |
| 25 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.39654316 |
| 26 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.39274229 |
| 27 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.37080393 |
| 28 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.30281868 |
| 29 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.28852616 |
| 30 | Allograft rejection_Homo sapiens_hsa05330 | 1.27321668 |
| 31 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.25455191 |
| 32 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.23308171 |
| 33 | Galactose metabolism_Homo sapiens_hsa00052 | 1.20759589 |
| 34 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.20480015 |
| 35 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.19451722 |
| 36 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.18219364 |
| 37 | Purine metabolism_Homo sapiens_hsa00230 | 1.17136125 |
| 38 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.15810635 |
| 39 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.13380404 |
| 40 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.10194784 |
| 41 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.08651338 |
| 42 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.08169963 |
| 43 | Viral myocarditis_Homo sapiens_hsa05416 | 1.07555668 |
| 44 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.07046653 |
| 45 | Basal transcription factors_Homo sapiens_hsa03022 | 1.06282944 |
| 46 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.06282015 |
| 47 | Ribosome_Homo sapiens_hsa03010 | 1.04598567 |
| 48 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.98410599 |
| 49 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.90842952 |
| 50 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.89385191 |
| 51 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.87719092 |
| 52 | RNA degradation_Homo sapiens_hsa03018 | 0.85076444 |
| 53 | Carbon metabolism_Homo sapiens_hsa01200 | 0.84711907 |
| 54 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.83193684 |
| 55 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.77147719 |
| 56 | Metabolic pathways_Homo sapiens_hsa01100 | 0.76265475 |
| 57 | Mineral absorption_Homo sapiens_hsa04978 | 0.72250417 |
| 58 | Spliceosome_Homo sapiens_hsa03040 | 0.71551131 |
| 59 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.71062680 |
| 60 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.68530496 |
| 61 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.66371299 |
| 62 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.62351928 |
| 63 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.62167723 |
| 64 | Peroxisome_Homo sapiens_hsa04146 | 0.60911236 |
| 65 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.58590663 |
| 66 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.57441542 |
| 67 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.57031386 |
| 68 | RNA transport_Homo sapiens_hsa03013 | 0.56971561 |
| 69 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.56293248 |
| 70 | Alcoholism_Homo sapiens_hsa05034 | 0.56223913 |
| 71 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.52816943 |
| 72 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.50917749 |
| 73 | Tight junction_Homo sapiens_hsa04530 | 0.50422408 |
| 74 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.47939939 |
| 75 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.47038481 |
| 76 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.46710868 |
| 77 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.45870718 |
| 78 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.44586662 |
| 79 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.43592746 |
| 80 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.41747137 |
| 81 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.40692032 |
| 82 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.40083485 |
| 83 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.39006859 |
| 84 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.38636002 |
| 85 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.36730710 |
| 86 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.34263359 |
| 87 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.32720343 |
| 88 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.31674315 |
| 89 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.30744584 |
| 90 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.29806073 |
| 91 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.29752915 |
| 92 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.29621718 |
| 93 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.29346674 |
| 94 | Shigellosis_Homo sapiens_hsa05131 | 0.25565592 |
| 95 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.25035544 |
| 96 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.22805820 |
| 97 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.22065672 |
| 98 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.21970787 |
| 99 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.21384809 |
| 100 | Insulin secretion_Homo sapiens_hsa04911 | 0.21222650 |

