POTEJ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to gravity (GO:0009629)7.17144725
2protein maturation by protein folding (GO:0022417)5.92206480
3detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)5.61797102
4regulation of gonadotropin secretion (GO:0032276)5.12151844
5negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.87364665
6cullin deneddylation (GO:0010388)4.74487462
7galactose catabolic process (GO:0019388)4.70688760
8mannosylation (GO:0097502)4.62290343
9establishment of viral latency (GO:0019043)4.61267574
10detection of chemical stimulus involved in sensory perception of taste (GO:0050912)4.57456927
11response to interferon-beta (GO:0035456)4.46166070
12protein deneddylation (GO:0000338)4.41469648
13positive regulation of actin filament depolymerization (GO:0030836)4.37535334
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.35732947
15negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.33977059
16regulation of skeletal muscle contraction (GO:0014819)4.29290297
17protein complex biogenesis (GO:0070271)4.25814176
18proteasome assembly (GO:0043248)4.20942997
19regulation of cellular amino acid metabolic process (GO:0006521)4.20337506
20establishment of integrated proviral latency (GO:0075713)4.17376645
21deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.14184095
22positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.12223666
23positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.12015871
24type B pancreatic cell proliferation (GO:0044342)4.10709740
25extracellular fibril organization (GO:0043206)4.10060185
26DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.09773791
27NADH dehydrogenase complex assembly (GO:0010257)4.03237360
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.03237360
29mitochondrial respiratory chain complex I assembly (GO:0032981)4.03237360
30intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.93025591
31signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.93025591
32signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.90172697
33signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.90172697
34signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.90172697
35mitochondrial respiratory chain complex assembly (GO:0033108)3.82127137
36signal transduction involved in cell cycle checkpoint (GO:0072395)3.81675433
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.81080825
38negative regulation of ligase activity (GO:0051352)3.81080825
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.80735805
40signal transduction involved in DNA integrity checkpoint (GO:0072401)3.77123113
41signal transduction involved in DNA damage checkpoint (GO:0072422)3.77123113
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.64900740
43termination of RNA polymerase III transcription (GO:0006386)3.47072807
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.47072807
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.44927384
46cellular response to interferon-beta (GO:0035458)3.42515214
47DNA deamination (GO:0045006)3.40586894
48C-terminal protein lipidation (GO:0006501)3.40297805
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.36907598
50positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.34609691
51ATP synthesis coupled proton transport (GO:0015986)3.34106610
52energy coupled proton transport, down electrochemical gradient (GO:0015985)3.34106610
53xenobiotic catabolic process (GO:0042178)3.33213279
54DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.30896176
55GDP-mannose metabolic process (GO:0019673)3.25897334
56muscle cell migration (GO:0014812)3.23942780
57galactose metabolic process (GO:0006012)3.19409045
58actin filament depolymerization (GO:0030042)3.19098686
59sequestering of actin monomers (GO:0042989)3.17540233
60fibril organization (GO:0097435)3.16091277
61antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.15321391
62platelet dense granule organization (GO:0060155)3.12165983
63positive regulation of interleukin-8 secretion (GO:2000484)3.10693046
64positive regulation of ligase activity (GO:0051351)3.10028738
65preassembly of GPI anchor in ER membrane (GO:0016254)3.09123695
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.08654955
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.08654955
68C-terminal protein amino acid modification (GO:0018410)3.06989047
69Golgi transport vesicle coating (GO:0048200)3.06865013
70COPI coating of Golgi vesicle (GO:0048205)3.06865013
71endothelial tube morphogenesis (GO:0061154)3.04754406
72morphogenesis of an endothelium (GO:0003159)3.04754406
73* retina homeostasis (GO:0001895)3.00716408
74regulation of metalloenzyme activity (GO:0048552)2.99669893
75positive regulation of cell cycle arrest (GO:0071158)2.98357520
76positive regulation of growth hormone secretion (GO:0060124)2.97121985
77regulation of cellular amine metabolic process (GO:0033238)2.94907672
78negative regulation of JAK-STAT cascade (GO:0046426)2.94886330
79negative regulation of B cell apoptotic process (GO:0002903)2.93526882
80electron transport chain (GO:0022900)2.88953960
81establishment of protein localization to mitochondrial membrane (GO:0090151)2.85648790
82response to testosterone (GO:0033574)2.84940065
83nucleoside transmembrane transport (GO:1901642)2.84468507
84adenosine metabolic process (GO:0046085)2.83891254
85respiratory electron transport chain (GO:0022904)2.83796006
86antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.83735576
87mitochondrial calcium ion homeostasis (GO:0051560)2.83519428
88mitotic nuclear envelope reassembly (GO:0007084)2.80579183
89nuclear envelope reassembly (GO:0031468)2.80579183
90AMP metabolic process (GO:0046033)2.80535766
91GTP biosynthetic process (GO:0006183)2.76059144
92mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.75736856
93spliceosomal snRNP assembly (GO:0000387)2.75023715
94positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.74835236
95protein heterotetramerization (GO:0051290)2.71033431
96endothelial cell chemotaxis (GO:0035767)2.70542463
97signal transduction in response to DNA damage (GO:0042770)2.68719549
98lung secretory cell differentiation (GO:0061140)2.68291866
99regulation of interleukin-8 secretion (GO:2000482)2.68071447
100regulation of cell cycle arrest (GO:0071156)2.68052455

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.99226345
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.64107932
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.10738540
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.04565642
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.88129447
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.60520638
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.47922512
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.15886501
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.03332604
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.82521162
11SRF_21415370_ChIP-Seq_HL-1_Mouse2.75882615
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.69666242
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.62318033
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.60864987
15ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.59372335
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.44673600
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40820340
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.27617645
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.27523428
20YY1_21170310_ChIP-Seq_MESCs_Mouse2.24094570
21VDR_22108803_ChIP-Seq_LS180_Human2.23462345
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19258884
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19100708
24VDR_23849224_ChIP-Seq_CD4+_Human2.15285148
25ELK1_19687146_ChIP-ChIP_HELA_Human2.09875602
26DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.02310290
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99807508
28ELK1_22589737_ChIP-Seq_MCF10A_Human1.87841693
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.87106266
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83774091
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.80447626
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79724715
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69591659
34CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.67129181
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65363692
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64678859
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.59421548
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59229578
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.58795754
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58472392
41CBP_21632823_ChIP-Seq_H3396_Human1.58008164
42GABP_19822575_ChIP-Seq_HepG2_Human1.57136718
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56264025
44EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.48132923
45DCP1A_22483619_ChIP-Seq_HELA_Human1.43417555
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42880433
47JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38093437
48JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37533750
49RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.37450206
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37046501
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28951114
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27569924
53CTCF_18555785_ChIP-Seq_MESCs_Mouse1.25740623
54PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.22126940
55CSB_26484114_Chip-Seq_FIBROBLAST_Human1.20913325
56BCL6_27268052_Chip-Seq_Bcells_Human1.20235929
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20020726
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19920261
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18670401
60STAT1_20625510_ChIP-Seq_HELA_Human1.18440747
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17790904
62SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16006602
63SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16006602
64CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.15896976
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15744791
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.15011735
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14298603
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13902436
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13761464
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.12642085
71CTCF_20526341_ChIP-Seq_ESCs_Human1.12619540
72P300_27268052_Chip-Seq_Bcells_Human1.11980946
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10879967
74ZNF274_21170338_ChIP-Seq_K562_Hela1.09835481
75IRF8_22096565_ChIP-ChIP_GC-B_Human1.09330854
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08451261
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07424710
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05862857
79FOXP3_21729870_ChIP-Seq_TREG_Human1.04222498
80AR_20517297_ChIP-Seq_VCAP_Human1.04094741
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03654012
82BCOR_27268052_Chip-Seq_Bcells_Human1.01837559
83NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01174916
84MYC_18940864_ChIP-ChIP_HL60_Human1.00838739
85XRN2_22483619_ChIP-Seq_HELA_Human1.00467771
86MYC_18555785_ChIP-Seq_MESCs_Mouse1.00449388
87ELF5_23300383_ChIP-Seq_T47D_Human1.00431973
88E2F1_20622854_ChIP-Seq_HELA_Human1.00157227
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99781916
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98120025
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.97841692
92CJUN_26792858_Chip-Seq_BT549_Human0.97506523
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95129562
94EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94441798
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94403821
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94039769
97EOMES_21245162_ChIP-Seq_HESCs_Human0.93660552
98YY1_22570637_ChIP-Seq_MALME-3M_Human0.93013802
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91518392
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91501563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology5.02488924
2MP0003806_abnormal_nucleotide_metabolis3.29226087
3MP0005379_endocrine/exocrine_gland_phen3.07652119
4MP0003191_abnormal_cellular_cholesterol3.00310491
5MP0005083_abnormal_biliary_tract2.85436252
6MP0002138_abnormal_hepatobiliary_system2.73972673
7MP0000749_muscle_degeneration2.73022792
8MP0003718_maternal_effect2.68829841
9MP0000613_abnormal_salivary_gland2.58808073
10MP0004510_myositis2.52506066
11MP0004147_increased_porphyrin_level2.48997492
12MP0000647_abnormal_sebaceous_gland2.30176796
13MP0006072_abnormal_retinal_apoptosis2.18923285
14MP0003786_premature_aging2.17726932
15MP0001542_abnormal_bone_strength2.17506617
16MP0005165_increased_susceptibility_to1.98626625
17MP0000751_myopathy1.97909737
18MP0001905_abnormal_dopamine_level1.92469920
19MP0010030_abnormal_orbit_morphology1.86503210
20MP0003315_abnormal_perineum_morphology1.81925573
21MP0006054_spinal_hemorrhage1.71572295
22MP0000750_abnormal_muscle_regeneration1.70561234
23MP0002006_tumorigenesis1.68728976
24MP0004043_abnormal_pH_regulation1.68084149
25MP0005084_abnormal_gallbladder_morpholo1.63618943
26MP0001243_abnormal_dermal_layer1.62001616
27MP0000747_muscle_weakness1.58350762
28MP0004145_abnormal_muscle_electrophysio1.56337015
29MP0005330_cardiomyopathy1.49823429
30MP0006035_abnormal_mitochondrial_morpho1.46536685
31MP0004272_abnormal_basement_membrane1.45276682
32MP0008775_abnormal_heart_ventricle1.40727046
33MP0002166_altered_tumor_susceptibility1.40692545
34MP0002822_catalepsy1.37630401
35MP0002332_abnormal_exercise_endurance1.28917299
36MP0008875_abnormal_xenobiotic_pharmacok1.27716823
37MP0003638_abnormal_response/metabolism_1.27625100
38MP0000465_gastrointestinal_hemorrhage1.26248141
39MP0002106_abnormal_muscle_physiology1.26070446
40MP0003075_altered_response_to1.25740532
41MP0002736_abnormal_nociception_after1.23030713
42MP0000639_abnormal_adrenal_gland1.21233427
43MP0001968_abnormal_touch/_nociception1.13258821
44MP0005620_abnormal_muscle_contractility1.12256049
45MP0002282_abnormal_trachea_morphology1.10783238
46MP0002277_abnormal_respiratory_mucosa1.10147435
47MP0000372_irregular_coat_pigmentation1.07749338
48MP0000013_abnormal_adipose_tissue1.06982235
49MP0005410_abnormal_fertilization1.05451152
50MP0003011_delayed_dark_adaptation1.04879005
51MP0010386_abnormal_urinary_bladder1.04726225
52MP0005646_abnormal_pituitary_gland1.00570743
53MP0004142_abnormal_muscle_tone0.99416619
54MP0000358_abnormal_cell_content/0.98600261
55MP0002837_dystrophic_cardiac_calcinosis0.98319549
56MP0003950_abnormal_plasma_membrane0.96444014
57MP0009780_abnormal_chondrocyte_physiolo0.96433674
58MP0005369_muscle_phenotype0.95471134
59MP0008872_abnormal_physiological_respon0.94865588
60MP0006036_abnormal_mitochondrial_physio0.94257749
61MP0009764_decreased_sensitivity_to0.91772869
62MP0001879_abnormal_lymphatic_vessel0.90217795
63MP0005257_abnormal_intraocular_pressure0.90206581
64MP0005253_abnormal_eye_physiology0.89601457
65MP0010368_abnormal_lymphatic_system0.89016482
66MP0008438_abnormal_cutaneous_collagen0.87895955
67MP0009046_muscle_twitch0.87826056
68MP0004134_abnormal_chest_morphology0.87151198
69MP0001756_abnormal_urination0.83405896
70MP0003866_abnormal_defecation0.82222423
71MP0001873_stomach_inflammation0.82134965
72MP0002876_abnormal_thyroid_physiology0.80577926
73MP0002210_abnormal_sex_determination0.80001134
74MP0005167_abnormal_blood-brain_barrier0.79807472
75MP0002733_abnormal_thermal_nociception0.79647780
76MP0003123_paternal_imprinting0.79276198
77MP0002148_abnormal_hypersensitivity_rea0.78984658
78MP0002653_abnormal_ependyma_morphology0.77264573
79MP0002735_abnormal_chemical_nociception0.76015377
80MP0002269_muscular_atrophy0.75849380
81MP0002972_abnormal_cardiac_muscle0.75279932
82MP0002089_abnormal_postnatal_growth/wei0.75265127
83MP0003880_abnormal_central_pattern0.73073216
84MP0002272_abnormal_nervous_system0.71735450
85MP0005367_renal/urinary_system_phenotyp0.71048092
86MP0000516_abnormal_urinary_system0.71048092
87MP0005395_other_phenotype0.70885553
88MP0005166_decreased_susceptibility_to0.67227174
89MP0002295_abnormal_pulmonary_circulatio0.66008008
90MP0008058_abnormal_DNA_repair0.65102879
91MP0002060_abnormal_skin_morphology0.64988847
92MP0005085_abnormal_gallbladder_physiolo0.63221632
93MP0001765_abnormal_ion_homeostasis0.59745959
94MP0000759_abnormal_skeletal_muscle0.59230931
95MP0000762_abnormal_tongue_morphology0.58561555
96MP0000230_abnormal_systemic_arterial0.58068118
97MP0001835_abnormal_antigen_presentation0.56811438
98MP0005670_abnormal_white_adipose0.56681288
99MP0005551_abnormal_eye_electrophysiolog0.56298211
100MP0001970_abnormal_pain_threshold0.54943459

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)4.38313486
2Congenital, generalized hypertrichosis (HP:0004540)4.26121416
3Palpebral edema (HP:0100540)4.06764203
4Hepatic necrosis (HP:0002605)4.02153498
5Adrenal hypoplasia (HP:0000835)3.95762954
6Acute necrotizing encephalopathy (HP:0006965)3.87309130
7Mitochondrial inheritance (HP:0001427)3.84489029
8Glucose intolerance (HP:0000833)3.74715150
9Abnormal mitochondria in muscle tissue (HP:0008316)3.57457181
10Reduced subcutaneous adipose tissue (HP:0003758)3.56448671
11Delayed CNS myelination (HP:0002188)3.39366393
12Type I transferrin isoform profile (HP:0003642)3.37956064
13Acute encephalopathy (HP:0006846)3.37598574
14Increased CSF lactate (HP:0002490)3.29518497
15Progressive macrocephaly (HP:0004481)3.04984089
16Palpitations (HP:0001962)2.89186496
17Reduced antithrombin III activity (HP:0001976)2.88300266
18Amyloidosis (HP:0011034)2.66990582
19Cholecystitis (HP:0001082)2.64332403
20Abnormal gallbladder physiology (HP:0012438)2.64332403
21Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.61417862
22Abnormal protein N-linked glycosylation (HP:0012347)2.61417862
23Abnormal protein glycosylation (HP:0012346)2.61417862
24Abnormal glycosylation (HP:0012345)2.61417862
25Cerebral edema (HP:0002181)2.60679175
26Severe muscular hypotonia (HP:0006829)2.60037369
27Elevated erythrocyte sedimentation rate (HP:0003565)2.57489342
28Opisthotonus (HP:0002179)2.53451621
29Conjunctival hamartoma (HP:0100780)2.53399625
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52929782
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52929782
32Exercise intolerance (HP:0003546)2.49292784
33Abnormal glucose tolerance (HP:0001952)2.48200785
34Increased serum lactate (HP:0002151)2.47513383
35Lactic acidosis (HP:0003128)2.45950466
36Entropion (HP:0000621)2.40253529
37Large for gestational age (HP:0001520)2.40199306
38Sparse eyelashes (HP:0000653)2.39819745
39Abnormality of midbrain morphology (HP:0002418)2.39342760
40Molar tooth sign on MRI (HP:0002419)2.39342760
41Flat capital femoral epiphysis (HP:0003370)2.35161488
42Vacuolated lymphocytes (HP:0001922)2.33610633
43Microretrognathia (HP:0000308)2.32118130
44Insulin resistance (HP:0000855)2.28951289
45Abnormal spermatogenesis (HP:0008669)2.26897464
46Prolonged neonatal jaundice (HP:0006579)2.24978913
47J-shaped sella turcica (HP:0002680)2.23595727
48Facial edema (HP:0000282)2.23481601
49Increased hepatocellular lipid droplets (HP:0006565)2.22966960
50Methylmalonic aciduria (HP:0012120)2.22821203
51Insulin-resistant diabetes mellitus (HP:0000831)2.21002893
52Dysautonomia (HP:0002459)2.20399772
53Periorbital edema (HP:0100539)2.19567971
54Respiratory failure (HP:0002878)2.19424198
55Hypoplastic pelvis (HP:0008839)2.18640067
56Prostate neoplasm (HP:0100787)2.18286012
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.16875272
58Myoglobinuria (HP:0002913)2.10293108
59True hermaphroditism (HP:0010459)2.10245438
60Generalized aminoaciduria (HP:0002909)2.06355866
61Large eyes (HP:0001090)2.05652291
62Renal Fanconi syndrome (HP:0001994)2.05029480
63Pancreatic cysts (HP:0001737)2.03926658
64Abnormality of the distal phalanges of the toes (HP:0010182)2.03208154
65Microglossia (HP:0000171)2.02946745
66Abnormal number of erythroid precursors (HP:0012131)2.02838412
67Progressive microcephaly (HP:0000253)2.00798169
68Hypoplasia of the uterus (HP:0000013)2.00084736
69Increased serum pyruvate (HP:0003542)1.99512161
70Gliosis (HP:0002171)1.97558882
71Optic nerve coloboma (HP:0000588)1.96721848
723-Methylglutaconic aciduria (HP:0003535)1.94662264
73Short nail (HP:0001799)1.94458545
74Optic disc pallor (HP:0000543)1.92618514
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92174852
76Pancreatic fibrosis (HP:0100732)1.90258900
77Aplasia/hypoplasia of the uterus (HP:0008684)1.89626965
78Lissencephaly (HP:0001339)1.89518556
79Limb-girdle muscle atrophy (HP:0003797)1.89231465
80Late onset (HP:0003584)1.88720811
81Hand muscle atrophy (HP:0009130)1.88194036
82Abnormality of glycolysis (HP:0004366)1.87397479
83Severe visual impairment (HP:0001141)1.86977667
84Abnormal autonomic nervous system physiology (HP:0012332)1.86966071
85Retinal dysplasia (HP:0007973)1.86884541
86Conjugated hyperbilirubinemia (HP:0002908)1.84524848
87Rough bone trabeculation (HP:0100670)1.83530343
88Erythema (HP:0010783)1.83129106
89Shoulder girdle muscle weakness (HP:0003547)1.83016536
90Increased intramyocellular lipid droplets (HP:0012240)1.82255792
91Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81975528
92Abnormality of the musculature of the pelvis (HP:0001469)1.81088669
93Abnormality of the hip-girdle musculature (HP:0001445)1.81088669
94Bifid uvula (HP:0000193)1.80810794
95CNS demyelination (HP:0007305)1.80367564
96Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80216215
97Lipid accumulation in hepatocytes (HP:0006561)1.79342941
98Ulnar deviation of the wrist (HP:0003049)1.78017663
99Bone cyst (HP:0012062)1.77144744
100Increased connective tissue (HP:0009025)1.76748551

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.96356411
2LMTK24.59325186
3TESK14.04913783
4NME23.98859255
5TESK23.62714527
6LIMK13.38962204
7TLK13.06997354
8PHKG22.69631838
9PHKG12.69631838
10BCKDK2.58343471
11EPHA22.55811577
12BUB12.52721094
13MST1R2.49627540
14VRK12.23717986
15ZAK2.07188030
16TAF12.00619362
17MAP2K72.00244977
18DAPK11.93488605
19MAP3K121.84891488
20TIE11.73664766
21ARAF1.61393588
22MST41.58901231
23CSNK1G31.54718295
24CSNK1A1L1.47446815
25MAPKAPK31.44322641
26NUAK11.38991589
27CSNK1G21.30588189
28PIM21.30220739
29MYLK1.29918847
30INSRR1.28878117
31CDK81.26555616
32NEK11.17754364
33CSNK1G11.11967330
34CCNB11.08786408
35DAPK21.08646712
36WNK41.04880173
37KDR0.98892891
38ERBB30.81734051
39AURKA0.77690258
40HIPK20.75929659
41TSSK60.75702013
42PTK2B0.75233193
43BCR0.72573685
44MAPKAPK50.72043241
45SCYL20.71720829
46MOS0.69825732
47OBSCN0.67727598
48GRK10.67136654
49DAPK30.65517528
50PAK40.65453306
51ABL20.64315390
52SRPK10.64091495
53STK160.64000176
54STK100.60457504
55WNK30.58876498
56RPS6KA50.57946919
57MAP4K20.53091509
58PDK20.50876007
59CAMK2G0.47078048
60ERBB40.46735780
61GRK50.46625648
62GRK70.46470421
63MAPK130.45157457
64MUSK0.45049561
65OXSR10.44517016
66BMPR1B0.44336655
67TRIM280.42330898
68CAMKK20.41723639
69FER0.40660569
70ILK0.39294357
71MET0.38195602
72DYRK20.36507443
73STK380.36228980
74MAP2K60.35723702
75EPHB20.35189576
76EIF2AK20.35019974
77ADRBK10.34448015
78PRKCI0.34316860
79TBK10.34199161
80TAOK20.33875702
81PINK10.33367086
82MAP3K40.32554389
83STK390.31685778
84CDK70.31582550
85BLK0.30547843
86BRSK10.28937945
87PAK10.26173322
88KIT0.24955299
89ADRBK20.24244710
90EPHB10.24118938
91PLK30.22848086
92SIK30.22726496
93SMG10.21447101
94IKBKE0.21281387
95BRAF0.19994742
96PRKACB0.19882834
97CDK190.19629093
98IRAK30.18218287
99CAMK2D0.17968342
100AURKB0.17907792

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.71894480
2Oxidative phosphorylation_Homo sapiens_hsa001903.44579147
3Parkinsons disease_Homo sapiens_hsa050122.83439524
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.78755614
5RNA polymerase_Homo sapiens_hsa030202.66571087
6Alzheimers disease_Homo sapiens_hsa050102.29888334
7Huntingtons disease_Homo sapiens_hsa050162.25389185
8DNA replication_Homo sapiens_hsa030302.23490921
9Base excision repair_Homo sapiens_hsa034102.23300343
10Folate biosynthesis_Homo sapiens_hsa007902.18838947
11Salivary secretion_Homo sapiens_hsa049702.01946643
12Fatty acid elongation_Homo sapiens_hsa000621.96181940
13Asthma_Homo sapiens_hsa053101.88201068
14Pyrimidine metabolism_Homo sapiens_hsa002401.79719713
15Mismatch repair_Homo sapiens_hsa034301.75244593
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53948112
17Sulfur relay system_Homo sapiens_hsa041221.50400970
18Nucleotide excision repair_Homo sapiens_hsa034201.47956469
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.47663642
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47283873
21Homologous recombination_Homo sapiens_hsa034401.46654247
22Protein export_Homo sapiens_hsa030601.45620446
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43675502
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42481501
25Vibrio cholerae infection_Homo sapiens_hsa051101.39654316
26Systemic lupus erythematosus_Homo sapiens_hsa053221.39274229
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37080393
28Cardiac muscle contraction_Homo sapiens_hsa042601.30281868
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28852616
30Allograft rejection_Homo sapiens_hsa053301.27321668
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25455191
32Autoimmune thyroid disease_Homo sapiens_hsa053201.23308171
33Galactose metabolism_Homo sapiens_hsa000521.20759589
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20480015
35Glutathione metabolism_Homo sapiens_hsa004801.19451722
36Pyruvate metabolism_Homo sapiens_hsa006201.18219364
37Purine metabolism_Homo sapiens_hsa002301.17136125
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.15810635
39Antigen processing and presentation_Homo sapiens_hsa046121.13380404
40Pentose phosphate pathway_Homo sapiens_hsa000301.10194784
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08651338
42Type I diabetes mellitus_Homo sapiens_hsa049401.08169963
43Viral myocarditis_Homo sapiens_hsa054161.07555668
44Fructose and mannose metabolism_Homo sapiens_hsa000511.07046653
45Basal transcription factors_Homo sapiens_hsa030221.06282944
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06282015
47Ribosome_Homo sapiens_hsa030101.04598567
48Biosynthesis of amino acids_Homo sapiens_hsa012300.98410599
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90842952
50Graft-versus-host disease_Homo sapiens_hsa053320.89385191
51Propanoate metabolism_Homo sapiens_hsa006400.87719092
52RNA degradation_Homo sapiens_hsa030180.85076444
53Carbon metabolism_Homo sapiens_hsa012000.84711907
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83193684
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77147719
56Metabolic pathways_Homo sapiens_hsa011000.76265475
57Mineral absorption_Homo sapiens_hsa049780.72250417
58Spliceosome_Homo sapiens_hsa030400.71551131
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71062680
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68530496
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66371299
62Steroid biosynthesis_Homo sapiens_hsa001000.62351928
63Chemical carcinogenesis_Homo sapiens_hsa052040.62167723
64Peroxisome_Homo sapiens_hsa041460.60911236
65Oocyte meiosis_Homo sapiens_hsa041140.58590663
66Sulfur metabolism_Homo sapiens_hsa009200.57441542
67Rheumatoid arthritis_Homo sapiens_hsa053230.57031386
68RNA transport_Homo sapiens_hsa030130.56971561
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.56293248
70Alcoholism_Homo sapiens_hsa050340.56223913
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52816943
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.50917749
73Tight junction_Homo sapiens_hsa045300.50422408
74N-Glycan biosynthesis_Homo sapiens_hsa005100.47939939
75Regulation of autophagy_Homo sapiens_hsa041400.47038481
76Epstein-Barr virus infection_Homo sapiens_hsa051690.46710868
77Arachidonic acid metabolism_Homo sapiens_hsa005900.45870718
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44586662
79Fatty acid biosynthesis_Homo sapiens_hsa000610.43592746
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41747137
81Fanconi anemia pathway_Homo sapiens_hsa034600.40692032
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.40083485
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39006859
84Arginine and proline metabolism_Homo sapiens_hsa003300.38636002
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36730710
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34263359
87Tryptophan metabolism_Homo sapiens_hsa003800.32720343
88One carbon pool by folate_Homo sapiens_hsa006700.31674315
89Butanoate metabolism_Homo sapiens_hsa006500.30744584
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29806073
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29752915
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29621718
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29346674
94Shigellosis_Homo sapiens_hsa051310.25565592
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25035544
96Non-homologous end-joining_Homo sapiens_hsa034500.22805820
97Herpes simplex infection_Homo sapiens_hsa051680.22065672
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21970787
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21384809
100Insulin secretion_Homo sapiens_hsa049110.21222650

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