POTEKP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fat-soluble vitamin catabolic process (GO:0042363)9.43997816
2vitamin catabolic process (GO:0009111)9.43997816
3mature B cell differentiation involved in immune response (GO:0002313)8.90361193
4regulation of female receptivity (GO:0045924)8.43577384
5skeletal muscle tissue regeneration (GO:0043403)7.94398409
6female mating behavior (GO:0060180)7.34108797
7negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)7.25599379
8phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)7.17926943
9positive regulation of inositol phosphate biosynthetic process (GO:0060732)6.32992354
10mature B cell differentiation (GO:0002335)6.24256964
11DNA deamination (GO:0045006)6.05039753
12morphogenesis of an endothelium (GO:0003159)5.70249985
13endothelial tube morphogenesis (GO:0061154)5.70249985
14synaptic transmission, dopaminergic (GO:0001963)5.59002938
15detection of light stimulus involved in visual perception (GO:0050908)5.42496308
16detection of light stimulus involved in sensory perception (GO:0050962)5.42496308
17negative regulation of oxidoreductase activity (GO:0051354)5.33900198
18lipoxygenase pathway (GO:0019372)5.32666772
19protein targeting to vacuole (GO:0006623)4.98613543
20protein targeting to lysosome (GO:0006622)4.98613543
21establishment of protein localization to vacuole (GO:0072666)4.98613543
22adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.97134514
23regulation of inositol phosphate biosynthetic process (GO:0010919)4.90150193
24cellular glucuronidation (GO:0052695)4.87231536
25polarized epithelial cell differentiation (GO:0030859)4.66223502
26coenzyme catabolic process (GO:0009109)4.61257815
27long term synaptic depression (GO:0060292)4.60830868
28uronic acid metabolic process (GO:0006063)4.57432801
29glucuronate metabolic process (GO:0019585)4.57432801
30pantothenate metabolic process (GO:0015939)4.56199510
31positive regulation of cAMP-mediated signaling (GO:0043950)4.44853555
32regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.40122349
33embryonic heart tube development (GO:0035050)4.34027368
34GTP biosynthetic process (GO:0006183)4.29446175
35glycosphingolipid biosynthetic process (GO:0006688)4.13989411
36lymphangiogenesis (GO:0001946)3.98219202
37collecting duct development (GO:0072044)3.97889075
38regulation of sensory perception (GO:0051931)3.96510064
39regulation of sensory perception of pain (GO:0051930)3.96510064
40positive regulation of calcium-mediated signaling (GO:0050850)3.96094907
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.95520181
42ATP synthesis coupled proton transport (GO:0015986)3.95520181
43positive regulation of interleukin-8 secretion (GO:2000484)3.88923171
44protein localization to lysosome (GO:0061462)3.87788902
45protein localization to vacuole (GO:0072665)3.87788902
46regulation of germinal center formation (GO:0002634)3.84507176
47regulation of MHC class II biosynthetic process (GO:0045346)3.84408665
48UTP biosynthetic process (GO:0006228)3.66633033
49neuronal action potential (GO:0019228)3.55617312
50transmission of nerve impulse (GO:0019226)3.48255792
51positive regulation of macrophage differentiation (GO:0045651)3.44212680
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.42864696
53RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.42864696
54negative regulation of monooxygenase activity (GO:0032769)3.41896203
55protein polyglutamylation (GO:0018095)3.38612170
56positive regulation of phosphatase activity (GO:0010922)3.31346585
57positive regulation of chemokine secretion (GO:0090197)3.28569998
58preassembly of GPI anchor in ER membrane (GO:0016254)3.28358647
59UTP metabolic process (GO:0046051)3.17832029
60primary amino compound metabolic process (GO:1901160)3.16137400
61sleep (GO:0030431)3.15419031
62L-fucose catabolic process (GO:0042355)3.15378851
63fucose catabolic process (GO:0019317)3.15378851
64L-fucose metabolic process (GO:0042354)3.15378851
65B cell activation involved in immune response (GO:0002312)3.11279684
66leukocyte tethering or rolling (GO:0050901)3.10464076
67endothelial cell development (GO:0001885)3.10263099
68pericardium development (GO:0060039)3.09853201
69positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08218597
70retina homeostasis (GO:0001895)3.08102053
71regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.06281508
72positive regulation of T cell migration (GO:2000406)3.05500079
73basic amino acid transport (GO:0015802)3.03427487
74regulation of calcium-mediated signaling (GO:0050848)3.01482085
75regulation of interleukin-8 secretion (GO:2000482)2.98786904
76positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.97871059
77adenosine metabolic process (GO:0046085)2.93338987
78regulation of chemokine secretion (GO:0090196)2.92899932
79regulation of macrophage chemotaxis (GO:0010758)2.89993120
80protein localization to cilium (GO:0061512)2.88424690
81receptor guanylyl cyclase signaling pathway (GO:0007168)2.88361210
82purine deoxyribonucleotide catabolic process (GO:0009155)2.87567834
83zinc ion homeostasis (GO:0055069)2.77427969
84CTP metabolic process (GO:0046036)2.76316421
85CTP biosynthetic process (GO:0006241)2.76316421
86regulation of megakaryocyte differentiation (GO:0045652)2.76210029
87regulation of transcription from RNA polymerase I promoter (GO:0006356)2.74470090
88regulation of glomerulus development (GO:0090192)2.73733069
89regulation of mesoderm development (GO:2000380)2.73410800
90response to gravity (GO:0009629)2.73165206
91mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.72498410
92tissue regeneration (GO:0042246)2.72494556
93cellular response to dsRNA (GO:0071359)2.71561193
94activation of adenylate cyclase activity (GO:0007190)2.70802840
95multicellular organismal reproductive behavior (GO:0033057)2.68084579
96regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.66902698
97detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.66654186
98DNA dealkylation (GO:0035510)2.66030283
99detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.65093891
100sequestering of actin monomers (GO:0042989)2.63975326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human4.29020444
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.05039745
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.65279476
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.30555438
5ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.27209518
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.07639029
7LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.03522148
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.00221832
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.84741064
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.81682302
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.81682302
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.81682302
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.46925963
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37509579
15TDRD3_21172665_ChIP-Seq_MCF-7_Human2.35235309
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.26131524
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25553225
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.96548455
19PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.92948352
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.92919098
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85825073
22VDR_22108803_ChIP-Seq_LS180_Human1.85821843
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84109833
24NCOR_22424771_ChIP-Seq_293T_Human1.78666308
25LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.72098815
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65866733
27GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.63448032
28AUTS2_25519132_ChIP-Seq_293T-REX_Human1.61615725
29CIITA_25753668_ChIP-Seq_RAJI_Human1.61491501
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58912619
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.57932203
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56153132
33BCL6_27268052_Chip-Seq_Bcells_Human1.55078303
34GBX2_23144817_ChIP-Seq_PC3_Human1.54066699
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53909467
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51893777
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49383486
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48742421
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45137145
40P53_21459846_ChIP-Seq_SAOS-2_Human1.43732819
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.43682319
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43321028
43PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.42052864
44EWS_26573619_Chip-Seq_HEK293_Human1.41211872
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39266534
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.37399105
47P68_20966046_ChIP-Seq_HELA_Human1.35731696
48CTCF_20526341_ChIP-Seq_ESCs_Human1.34695964
49RAC3_21632823_ChIP-Seq_H3396_Human1.34237418
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33665874
51EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.31577348
52SOX2_21211035_ChIP-Seq_LN229_Human1.31420484
53DROSHA_22980978_ChIP-Seq_HELA_Human1.30556339
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30358411
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.28523674
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.26951841
57BCOR_27268052_Chip-Seq_Bcells_Human1.26495441
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24698503
59RAD21_21589869_ChIP-Seq_MESCs_Mouse1.24651559
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.24520526
61TAF2_19829295_ChIP-Seq_ESCs_Human1.23530001
62TP53_22573176_ChIP-Seq_HFKS_Human1.23069054
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22083410
64FOXP3_21729870_ChIP-Seq_TREG_Human1.21582027
65BCAT_22108803_ChIP-Seq_LS180_Human1.20633829
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18594949
67ERA_21632823_ChIP-Seq_H3396_Human1.18499492
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18325216
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.17794206
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14858654
71VDR_23849224_ChIP-Seq_CD4+_Human1.13774389
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.13041295
73EST1_17652178_ChIP-ChIP_JURKAT_Human1.10254623
74FOXH1_21741376_ChIP-Seq_ESCs_Human1.10088612
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09121569
76PHF8_20622854_ChIP-Seq_HELA_Human1.07796203
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07334273
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07061941
79E2F1_20622854_ChIP-Seq_HELA_Human1.05358748
80ER_23166858_ChIP-Seq_MCF-7_Human1.04979340
81ELK1_19687146_ChIP-ChIP_HELA_Human1.04710611
82SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03919278
83MYC_19829295_ChIP-Seq_ESCs_Human1.03901072
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02064874
85RUNX_20019798_ChIP-Seq_JUKART_Human1.00096384
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96674489
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94119233
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93858309
89CTCF_26484167_Chip-Seq_Bcells_Mouse0.93853822
90ETS1_20019798_ChIP-Seq_JURKAT_Human0.93515708
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91898644
92FOXA1_25329375_ChIP-Seq_VCAP_Human0.91898644
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.90408615
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90241610
95OCT4_20526341_ChIP-Seq_ESCs_Human0.90080708
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90024445
97CBP_20019798_ChIP-Seq_JUKART_Human0.90024445
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89953181
99MYB_26560356_Chip-Seq_TH2_Human0.89279661
100OCT4_19829295_ChIP-Seq_ESCs_Human0.88550516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology8.64649657
2MP0002736_abnormal_nociception_after6.04594800
3MP0001968_abnormal_touch/_nociception4.68061346
4MP0005360_urolithiasis4.67464826
5MP0005409_darkened_coat_color4.60636254
6MP0005083_abnormal_biliary_tract3.61560633
7MP0003172_abnormal_lysosome_physiology3.57121172
8MP0009840_abnormal_foam_cell3.12071035
9MP0000678_abnormal_parathyroid_gland2.74224770
10MP0006276_abnormal_autonomic_nervous2.65679061
11MP0001873_stomach_inflammation2.63484138
12MP0002909_abnormal_adrenal_gland2.59506949
13MP0009697_abnormal_copulation2.43104144
14MP0005671_abnormal_response_to2.33119804
15MP0002734_abnormal_mechanical_nocicepti2.07199246
16MP0003724_increased_susceptibility_to1.94457104
17MP0002277_abnormal_respiratory_mucosa1.88338418
18MP0005646_abnormal_pituitary_gland1.80636082
19MP0008789_abnormal_olfactory_epithelium1.69173024
20MP0002148_abnormal_hypersensitivity_rea1.66631108
21MP0006072_abnormal_retinal_apoptosis1.62372998
22MP0003950_abnormal_plasma_membrane1.60181060
23MP0003646_muscle_fatigue1.52262056
24MP0002822_catalepsy1.46918517
25MP0002933_joint_inflammation1.38531775
26MP0001879_abnormal_lymphatic_vessel1.31651879
27MP0002928_abnormal_bile_duct1.22491489
28MP0008872_abnormal_physiological_respon1.20159662
29MP0004742_abnormal_vestibular_system1.17070842
30MP0009333_abnormal_splenocyte_physiolog1.09538683
31MP0000613_abnormal_salivary_gland1.06625854
32MP0001970_abnormal_pain_threshold1.04067486
33MP0001502_abnormal_circadian_rhythm1.02447935
34MP0000537_abnormal_urethra_morphology1.00146444
35MP0005499_abnormal_olfactory_system0.98323009
36MP0005394_taste/olfaction_phenotype0.98323009
37MP0004381_abnormal_hair_follicle0.98133036
38MP0009053_abnormal_anal_canal0.97876200
39MP0000049_abnormal_middle_ear0.96956060
40MP0002102_abnormal_ear_morphology0.96301188
41MP0004145_abnormal_muscle_electrophysio0.93920632
42MP0005645_abnormal_hypothalamus_physiol0.92366099
43MP0002282_abnormal_trachea_morphology0.92116504
44MP0005367_renal/urinary_system_phenotyp0.90615065
45MP0000516_abnormal_urinary_system0.90615065
46MP0002127_abnormal_cardiovascular_syste0.90181247
47MP0009384_cardiac_valve_regurgitation0.90009287
48MP0000534_abnormal_ureter_morphology0.88318107
49MP0000538_abnormal_urinary_bladder0.87478272
50MP0003938_abnormal_ear_development0.85736042
51MP0002735_abnormal_chemical_nociception0.85716257
52MP0005000_abnormal_immune_tolerance0.84338152
53MP0006292_abnormal_olfactory_placode0.82251537
54MP0001800_abnormal_humoral_immune0.81901430
55MP0003718_maternal_effect0.78473636
56MP0002249_abnormal_larynx_morphology0.77350516
57MP0002098_abnormal_vibrissa_morphology0.75913135
58MP0003119_abnormal_digestive_system0.74821619
59MP0000465_gastrointestinal_hemorrhage0.73266324
60MP0001984_abnormal_olfaction0.72294814
61MP0001529_abnormal_vocalization0.71838939
62MP0001835_abnormal_antigen_presentation0.70075323
63MP0005253_abnormal_eye_physiology0.69159456
64MP0002723_abnormal_immune_serum0.65492041
65MP0010771_integument_phenotype0.64278884
66MP0003763_abnormal_thymus_physiology0.62968034
67MP0002160_abnormal_reproductive_system0.61244651
68MP0001819_abnormal_immune_cell0.60734583
69MP0002420_abnormal_adaptive_immunity0.59750368
70MP0002166_altered_tumor_susceptibility0.59376620
71MP0009764_decreased_sensitivity_to0.57606101
72MP0000230_abnormal_systemic_arterial0.57438483
73MP0000026_abnormal_inner_ear0.57046271
74MP0004085_abnormal_heartbeat0.56978244
75MP0001963_abnormal_hearing_physiology0.56268578
76MP0002452_abnormal_antigen_presenting0.55578100
77MP0001919_abnormal_reproductive_system0.55091184
78MP0009785_altered_susceptibility_to0.54641298
79MP0001533_abnormal_skeleton_physiology0.54525624
80MP0002405_respiratory_system_inflammati0.54373802
81MP0009780_abnormal_chondrocyte_physiolo0.52293160
82MP0000249_abnormal_blood_vessel0.49949155
83MP0000467_abnormal_esophagus_morphology0.49932106
84MP0000383_abnormal_hair_follicle0.49729580
85MP0003195_calcinosis0.48329971
86MP0000470_abnormal_stomach_morphology0.47550287
87MP0005389_reproductive_system_phenotype0.47317400
88MP0002272_abnormal_nervous_system0.47136967
89MP0002138_abnormal_hepatobiliary_system0.46664748
90MP0003879_abnormal_hair_cell0.46350577
91MP0002419_abnormal_innate_immunity0.46048566
92MP0005025_abnormal_response_to0.45603845
93MP0004036_abnormal_muscle_relaxation0.45589936
94MP0001845_abnormal_inflammatory_respons0.45448333
95MP0001243_abnormal_dermal_layer0.44962446
96MP0000647_abnormal_sebaceous_gland0.44730438
97MP0002733_abnormal_thermal_nociception0.43999290
98MP0005377_hearing/vestibular/ear_phenot0.43504593
99MP0003878_abnormal_ear_physiology0.43504593
100MP0002896_abnormal_bone_mineralization0.43502396

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.21971989
2Absent/shortened dynein arms (HP:0200106)6.21971989
3Dysautonomia (HP:0002459)5.92342782
4Failure to thrive in infancy (HP:0001531)5.54738782
5Abnormality of cochlea (HP:0000375)5.49153546
6Poor head control (HP:0002421)5.29407221
7Abolished electroretinogram (ERG) (HP:0000550)5.05469739
8Decreased central vision (HP:0007663)4.81383409
9Keratoconjunctivitis sicca (HP:0001097)4.65712513
10Keratoconjunctivitis (HP:0001096)4.47982521
11Tinnitus (HP:0000360)4.46036481
12Absent phalangeal crease (HP:0006109)4.35048110
13Bony spicule pigmentary retinopathy (HP:0007737)4.25915315
14Morphological abnormality of the inner ear (HP:0011390)4.25496471
15Constricted visual fields (HP:0001133)4.18361537
16Lymphangioma (HP:0100764)4.17306129
17Abnormality of aspartate family amino acid metabolism (HP:0010899)3.96452050
18Attenuation of retinal blood vessels (HP:0007843)3.96344709
19Generalized aminoaciduria (HP:0002909)3.92917103
20Follicular hyperkeratosis (HP:0007502)3.78429078
21Abnormality of the proximal phalanges of the hand (HP:0009834)3.57181733
22Abnormal finger flexion creases (HP:0006143)3.51586689
23Round ear (HP:0100830)3.49204939
24Cone-rod dystrophy (HP:0000548)3.45171307
25Decreased electroretinogram (ERG) amplitude (HP:0000654)3.44253150
26Abnormal autonomic nervous system physiology (HP:0012332)3.41771292
27Morphological abnormality of the middle ear (HP:0008609)3.35121350
28Distal arthrogryposis (HP:0005684)3.29882119
29Increased corneal curvature (HP:0100692)3.28317353
30Keratoconus (HP:0000563)3.28317353
31Abnormal respiratory epithelium morphology (HP:0012253)3.26171491
32Abnormal respiratory motile cilium morphology (HP:0005938)3.26171491
33Ulnar deviation of the wrist (HP:0003049)3.24518723
34Abnormality of the costochondral junction (HP:0000919)2.95862450
35Nonimmune hydrops fetalis (HP:0001790)2.90337028
36Progressive microcephaly (HP:0000253)2.83596542
37Abnormal ciliary motility (HP:0012262)2.77195332
38Chest pain (HP:0100749)2.66498936
39Calcaneovalgus deformity (HP:0001848)2.65688809
40Abnormality of pain sensation (HP:0010832)2.63086113
41Impaired pain sensation (HP:0007328)2.63086113
42Pustule (HP:0200039)2.52707809
43B lymphocytopenia (HP:0010976)2.51159906
44Recurrent sinusitis (HP:0011108)2.48390108
45Keratitis (HP:0000491)2.47174716
46Deformed tarsal bones (HP:0008119)2.39398733
47Abnormality of the middle phalanges of the toes (HP:0010183)2.36610911
48IgG deficiency (HP:0004315)2.35155309
49Opisthotonus (HP:0002179)2.34118769
50J-shaped sella turcica (HP:0002680)2.33791042
51Stenosis of the external auditory canal (HP:0000402)2.31066024
52Poor suck (HP:0002033)2.29580797
53Severe combined immunodeficiency (HP:0004430)2.28314069
54Mesangial abnormality (HP:0001966)2.28206086
55Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.27494630
56Flat capital femoral epiphysis (HP:0003370)2.24675338
57Short tibia (HP:0005736)2.21649455
58Abnormality of B cell number (HP:0010975)2.21609248
59Absent eyebrow (HP:0002223)2.19643349
60Aplastic anemia (HP:0001915)2.19528565
61Thyroiditis (HP:0100646)2.19190109
62Congenital stationary night blindness (HP:0007642)2.18276725
63Hamartoma of the eye (HP:0010568)2.16148291
64Aplasia/Hypoplasia of the tibia (HP:0005772)2.09189089
65Hypotrichosis (HP:0001006)2.06715876
66Abnormality of the renal collecting system (HP:0004742)2.05413772
67Abnormal respiratory motile cilium physiology (HP:0012261)2.03341309
68Abnormality of the phalanges of the 5th finger (HP:0004213)2.01746781
69Absent eyelashes (HP:0000561)1.99357327
70Lip pit (HP:0100267)1.95927924
71Symphalangism affecting the phalanges of the hand (HP:0009773)1.94492866
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94251332
73Abnormality of alanine metabolism (HP:0010916)1.94251332
74Hyperalaninemia (HP:0003348)1.94251332
75Arterial thrombosis (HP:0004420)1.91047723
76Abnormality of the nasal septum (HP:0000419)1.87423887
77Hypoplasia of the uterus (HP:0000013)1.86828127
78Long nose (HP:0003189)1.86367958
79Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.85917338
80Congenital, generalized hypertrichosis (HP:0004540)1.85247420
81Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.84949998
82Photophobia (HP:0000613)1.84049570
83Severe Myopia (HP:0011003)1.83545393
84Abnormality of serum amino acid levels (HP:0003112)1.82461942
85Vertigo (HP:0002321)1.79623112
86Obstructive sleep apnea (HP:0002870)1.73338176
87Conjunctival hamartoma (HP:0100780)1.73322039
88Abnormality of the peritoneum (HP:0002585)1.72783597
89Amaurosis fugax (HP:0100576)1.71901110
90Abnormality of the prostate (HP:0008775)1.70838336
91Abnormality of glutamine family amino acid metabolism (HP:0010902)1.70324779
92Methylmalonic aciduria (HP:0012120)1.69584584
93Prostate neoplasm (HP:0100787)1.68200131
94Synostosis involving the elbow (HP:0003938)1.67432737
95Humeroradial synostosis (HP:0003041)1.67432737
96Aortic valve stenosis (HP:0001650)1.67264679
97Abnormality of the renal cortex (HP:0011035)1.65861145
98Short femoral neck (HP:0100864)1.62884248
99Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.61345451
100Short hallux (HP:0010109)1.59578219

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K24.15342522
2NUAK13.66034411
3TESK23.62667587
4ZAK3.38714741
5TAOK33.11631116
6VRK22.93651356
7GRK12.66405666
8TXK2.66379135
9KDR2.64129853
10MAP4K22.38538482
11TLK12.32266837
12TESK12.05366082
13CDK41.91938664
14FRK1.90538454
15CSNK1G31.89348230
16MUSK1.88021010
17DAPK11.77978023
18BCKDK1.72437242
19STK381.68320172
20CSNK1A1L1.58604175
21CSNK1G21.50539961
22MAP2K11.46983396
23PIK3CA1.39723766
24VRK11.37114498
25MAP3K121.34952577
26GRK61.34387566
27MYLK1.33593774
28TIE11.31808629
29CSNK1G11.30678590
30SCYL21.27649589
31ZAP701.26433527
32PAK41.24346475
33INSRR1.17899211
34IKBKB1.10022193
35BMPR1B1.05217650
36ERBB21.03621954
37ADRBK21.03071756
38MAPKAPK31.01939424
39CCNB11.00493750
40CHEK20.99464527
41MAPKAPK50.97214916
42TAF10.96072212
43MAP4K10.95422369
44LMTK20.94731200
45LIMK10.94281479
46EPHA20.85999072
47CAMKK20.83902318
48MAP2K60.83690664
49IKBKE0.83306379
50TNK20.81849373
51MST40.80328274
52AURKA0.78414568
53NME20.77812667
54PLK20.77021193
55CDK190.73743348
56GRK50.73508108
57SYK0.72425120
58PHKG20.72289152
59PHKG10.72289152
60CHUK0.72116648
61PAK60.67458862
62HIPK20.67210324
63PTK20.62983274
64MAPK40.61174455
65MAPKAPK20.60269542
66TBK10.59483860
67SMG10.58592107
68PTK2B0.55879812
69WNK40.51811058
70CDK80.50434996
71LCK0.50004732
72PRKCI0.49764638
73OXSR10.48423608
74ITK0.48058898
75CSNK1A10.47061334
76OBSCN0.46479437
77RPS6KA20.45882015
78TEC0.45593114
79CAMK2B0.45194368
80DAPK30.44575685
81BLK0.42938643
82NME10.41246684
83ILK0.38073875
84EIF2AK20.37675843
85ABL20.37402749
86KIT0.37294129
87ROCK10.36918251
88RPS6KA50.35950414
89CSF1R0.34838300
90CDK70.33460428
91PRKCE0.32657286
92IGF1R0.31994418
93PRKCA0.30858373
94BMPR20.28740828
95ATR0.28508398
96ABL10.28099316
97NEK60.27030724
98PRKCQ0.26776696
99MAPK130.26186982
100PRKD10.25378324

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.86019166
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.77813774
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.48768172
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.19512595
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.99971261
6Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.69850521
7Asthma_Homo sapiens_hsa053102.38972593
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.38896814
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.36345060
10Olfactory transduction_Homo sapiens_hsa047402.34488154
11Drug metabolism - other enzymes_Homo sapiens_hsa009832.34218794
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.33284489
13Chemical carcinogenesis_Homo sapiens_hsa052042.27074035
14Primary immunodeficiency_Homo sapiens_hsa053402.20714855
15Phototransduction_Homo sapiens_hsa047442.12310024
16Retinol metabolism_Homo sapiens_hsa008302.10922605
17Starch and sucrose metabolism_Homo sapiens_hsa005002.10577123
18Homologous recombination_Homo sapiens_hsa034401.93205710
19Sulfur relay system_Homo sapiens_hsa041221.93167244
20Proteasome_Homo sapiens_hsa030501.92987490
21Allograft rejection_Homo sapiens_hsa053301.88000317
22Autoimmune thyroid disease_Homo sapiens_hsa053201.86880135
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.82539364
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81806616
25Systemic lupus erythematosus_Homo sapiens_hsa053221.50705563
26Graft-versus-host disease_Homo sapiens_hsa053321.48146289
27Histidine metabolism_Homo sapiens_hsa003401.47565643
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39739668
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30263774
30RNA polymerase_Homo sapiens_hsa030201.29433739
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27205133
32Ether lipid metabolism_Homo sapiens_hsa005651.25644039
33Arachidonic acid metabolism_Homo sapiens_hsa005901.19035597
34Type I diabetes mellitus_Homo sapiens_hsa049401.18652223
35Parkinsons disease_Homo sapiens_hsa050121.13742824
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12864845
37Oxidative phosphorylation_Homo sapiens_hsa001901.12191442
38Nitrogen metabolism_Homo sapiens_hsa009101.08576518
39Viral myocarditis_Homo sapiens_hsa054161.05720848
40Antigen processing and presentation_Homo sapiens_hsa046121.05380461
41DNA replication_Homo sapiens_hsa030301.00918080
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96733693
43Legionellosis_Homo sapiens_hsa051340.96587087
44Glycosaminoglycan degradation_Homo sapiens_hsa005310.92969608
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92167446
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91582337
47Fanconi anemia pathway_Homo sapiens_hsa034600.90939922
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82887862
49Hematopoietic cell lineage_Homo sapiens_hsa046400.81649277
50Alzheimers disease_Homo sapiens_hsa050100.80795753
51Rheumatoid arthritis_Homo sapiens_hsa053230.78809277
52Mismatch repair_Homo sapiens_hsa034300.76219716
53Glutathione metabolism_Homo sapiens_hsa004800.76079977
54beta-Alanine metabolism_Homo sapiens_hsa004100.75015278
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.74469181
56ABC transporters_Homo sapiens_hsa020100.70307465
57Taste transduction_Homo sapiens_hsa047420.66875682
58Steroid biosynthesis_Homo sapiens_hsa001000.66374554
59Tryptophan metabolism_Homo sapiens_hsa003800.63247564
60Lysine degradation_Homo sapiens_hsa003100.59698538
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58762113
62Peroxisome_Homo sapiens_hsa041460.57781154
63Glycerolipid metabolism_Homo sapiens_hsa005610.53879060
64Purine metabolism_Homo sapiens_hsa002300.50853227
65Protein digestion and absorption_Homo sapiens_hsa049740.50377756
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.48975021
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48289914
68Arginine and proline metabolism_Homo sapiens_hsa003300.48011042
69Protein export_Homo sapiens_hsa030600.47843176
70Base excision repair_Homo sapiens_hsa034100.47712951
71Metabolic pathways_Homo sapiens_hsa011000.46199622
72Alcoholism_Homo sapiens_hsa050340.45844441
73RNA degradation_Homo sapiens_hsa030180.44741099
74Lysosome_Homo sapiens_hsa041420.43887094
75Nicotine addiction_Homo sapiens_hsa050330.43345294
76Calcium signaling pathway_Homo sapiens_hsa040200.42091403
77Collecting duct acid secretion_Homo sapiens_hsa049660.41841855
78Caffeine metabolism_Homo sapiens_hsa002320.39562030
79Huntingtons disease_Homo sapiens_hsa050160.38220402
80Staphylococcus aureus infection_Homo sapiens_hsa051500.36621634
81Salivary secretion_Homo sapiens_hsa049700.35516724
82Cardiac muscle contraction_Homo sapiens_hsa042600.34757728
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.34662628
84Renin secretion_Homo sapiens_hsa049240.34488141
85Circadian entrainment_Homo sapiens_hsa047130.33772326
86Renin-angiotensin system_Homo sapiens_hsa046140.33539679
87T cell receptor signaling pathway_Homo sapiens_hsa046600.32548027
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32436753
89Herpes simplex infection_Homo sapiens_hsa051680.30718013
90Salmonella infection_Homo sapiens_hsa051320.27162574
91Measles_Homo sapiens_hsa051620.27005317
92Insulin secretion_Homo sapiens_hsa049110.25177893
93Spliceosome_Homo sapiens_hsa030400.24190365
94Pyrimidine metabolism_Homo sapiens_hsa002400.23940227
95Gastric acid secretion_Homo sapiens_hsa049710.22854166
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.20609618
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20010521
98cAMP signaling pathway_Homo sapiens_hsa040240.19660938
99p53 signaling pathway_Homo sapiens_hsa041150.15365474
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14718141

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