POU2AF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)8.20840161
2positive regulation of gamma-delta T cell activation (GO:0046645)6.88185847
3cytidine metabolic process (GO:0046087)6.50699528
4cytidine catabolic process (GO:0006216)6.50699528
5cytidine deamination (GO:0009972)6.50699528
6positive regulation of B cell differentiation (GO:0045579)6.03853740
7regulation of B cell differentiation (GO:0045577)5.88680391
8antigen processing and presentation of endogenous antigen (GO:0019883)5.37794435
9somatic hypermutation of immunoglobulin genes (GO:0016446)5.33574595
10somatic diversification of immune receptors via somatic mutation (GO:0002566)5.33574595
11regulation of gamma-delta T cell differentiation (GO:0045586)5.30117103
12CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.24347538
13regulation of B cell receptor signaling pathway (GO:0050855)4.94566732
14regulation of histone H3-K9 methylation (GO:0051570)4.90781606
15B cell proliferation (GO:0042100)4.86905579
16negative regulation of histone methylation (GO:0031061)4.84680608
17regulation of gamma-delta T cell activation (GO:0046643)4.79981838
18pyrimidine ribonucleoside catabolic process (GO:0046133)4.75023288
19cellular response to zinc ion (GO:0071294)4.52454323
20serine transport (GO:0032329)4.51758435
21regulation of B cell proliferation (GO:0030888)4.41916706
22regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.36847737
23microtubule depolymerization (GO:0007019)4.33094752
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.30386810
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.30386810
26sperm motility (GO:0030317)4.28183218
27L-serine transport (GO:0015825)4.24646003
28positive regulation of gene expression, epigenetic (GO:0045815)4.23362692
29V(D)J recombination (GO:0033151)4.17605568
30regulation of germinal center formation (GO:0002634)4.16561763
31T cell lineage commitment (GO:0002360)4.13882406
32snRNA transcription (GO:0009301)4.13147836
33B cell homeostasis (GO:0001782)4.12810325
34negative regulation of gene silencing (GO:0060969)4.11705963
35regulation of female gonad development (GO:2000194)4.10416907
36negative regulation of B cell proliferation (GO:0030889)4.00605879
37positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.99007171
38cilium or flagellum-dependent cell motility (GO:0001539)3.98202711
39positive regulation of protein homooligomerization (GO:0032464)3.95227174
40regulation of superoxide anion generation (GO:0032928)3.94534108
41mature B cell differentiation (GO:0002335)3.90914134
42regulation of sarcomere organization (GO:0060297)3.89015980
43regulation of B cell apoptotic process (GO:0002902)3.87525362
44lymphocyte homeostasis (GO:0002260)3.86363709
45regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.83275915
46chromosome condensation (GO:0030261)3.82667197
47negative regulation of phagocytosis (GO:0050765)3.78053562
48acrosome reaction (GO:0007340)3.77922665
49positive thymic T cell selection (GO:0045059)3.74278212
50response to type I interferon (GO:0034340)3.72526156
51DNA packaging (GO:0006323)3.69587756
52somatic diversification of immunoglobulins (GO:0016445)3.68455767
53antigen receptor-mediated signaling pathway (GO:0050851)3.65192521
54B cell activation (GO:0042113)3.64689275
55cellular response to type I interferon (GO:0071357)3.64602454
56type I interferon signaling pathway (GO:0060337)3.64602454
57cellular ketone body metabolic process (GO:0046950)3.56979906
58regulation of chromatin silencing (GO:0031935)3.56334046
59T cell homeostasis (GO:0043029)3.55470497
60somatic diversification of immune receptors (GO:0002200)3.55314268
61positive regulation of B cell proliferation (GO:0030890)3.54937917
62natural killer cell differentiation (GO:0001779)3.54378725
63immunoglobulin mediated immune response (GO:0016064)3.49031619
64germinal center formation (GO:0002467)3.47553789
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.46270249
66negative regulation of calcium ion transport into cytosol (GO:0010523)3.45992527
67positive regulation of B cell activation (GO:0050871)3.45726491
68monoubiquitinated protein deubiquitination (GO:0035520)3.45604540
69interferon-gamma-mediated signaling pathway (GO:0060333)3.44421061
70DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.44260192
71mucosal-associated lymphoid tissue development (GO:0048537)3.34335683
72Peyers patch development (GO:0048541)3.34335683
73mitotic sister chromatid cohesion (GO:0007064)3.33830333
74leukocyte homeostasis (GO:0001776)3.32994611
75regulation of interferon-beta biosynthetic process (GO:0045357)3.31925872
76immune response-activating cell surface receptor signaling pathway (GO:0002429)3.28495678
77regulation of interleukin-12 biosynthetic process (GO:0045075)3.28217389
78negative regulation of B cell apoptotic process (GO:0002903)3.27033530
79regulation of B cell activation (GO:0050864)3.26804663
80B cell differentiation (GO:0030183)3.26726486
81microtubule polymerization or depolymerization (GO:0031109)3.24742930
82positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.24707033
83regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.24707033
84positive regulation of histone deacetylation (GO:0031065)3.22402248
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22037011
86somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.21679261
87somatic cell DNA recombination (GO:0016444)3.21679261
88somatic recombination of immunoglobulin gene segments (GO:0016447)3.20448561
89regulation of alpha-beta T cell proliferation (GO:0046640)3.20292559
90immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00023.18764488
91Fc-gamma receptor signaling pathway (GO:0038094)3.18764488
92Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)3.18764488
93regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.18110017
94positive regulation of Rap GTPase activity (GO:0032854)3.15388253
95T cell migration (GO:0072678)3.13867009
96neutrophil activation (GO:0042119)3.13186490
97Fc receptor mediated stimulatory signaling pathway (GO:0002431)3.13116898
98B cell activation involved in immune response (GO:0002312)3.12101602
99negative regulation of bone resorption (GO:0045779)3.10983866
100pre-miRNA processing (GO:0031054)3.09990870
101DNA damage response, signal transduction resulting in transcription (GO:0042772)3.08613129
102ketone body metabolic process (GO:1902224)3.08587905
103hepatocyte apoptotic process (GO:0097284)3.08572192
104mononuclear cell proliferation (GO:0032943)3.07821856
105corticosteroid receptor signaling pathway (GO:0031958)3.06354567
106positive regulation of developmental pigmentation (GO:0048087)3.06248731
107glucocorticoid receptor signaling pathway (GO:0042921)3.06116966
108T cell selection (GO:0045058)3.05863405
109regulation of histone methylation (GO:0031060)3.05735204
110lymphocyte proliferation (GO:0046651)3.04730292
111chromatin silencing (GO:0006342)3.04084337
112sperm capacitation (GO:0048240)3.03542166
113regulation of interferon-gamma biosynthetic process (GO:0045072)3.02417893
114positive regulation of immunoglobulin production (GO:0002639)3.01035555
115positive regulation by host of viral transcription (GO:0043923)3.00046010
116multicellular organism reproduction (GO:0032504)2.99513840
117DNA unwinding involved in DNA replication (GO:0006268)2.96895215
118positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.94643428
119fusion of sperm to egg plasma membrane (GO:0007342)2.94600954
120spermatid development (GO:0007286)2.94104382
121protein K48-linked deubiquitination (GO:0071108)2.93201922
122defense response to protozoan (GO:0042832)2.92334923
123negative regulation of chromatin modification (GO:1903309)2.91803072
124regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.91166789
125vesicle targeting (GO:0006903)2.90798648
126regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.86785618
127macrophage activation involved in immune response (GO:0002281)2.86470711
128negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.85736249
129negative regulation of cell killing (GO:0031342)2.85736249
130regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.84210410
131positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.84210410
132tolerance induction (GO:0002507)2.83005556
133histone H3-K9 modification (GO:0061647)2.82996818
134negative thymic T cell selection (GO:0045060)2.82970591
135positive regulation of CREB transcription factor activity (GO:0032793)2.82929359
136single strand break repair (GO:0000012)2.82675209
137T cell costimulation (GO:0031295)2.82156067
138spermatid nucleus differentiation (GO:0007289)2.81825609
139DNA topological change (GO:0006265)2.81310934
140regulation of platelet aggregation (GO:0090330)2.81263161
141positive regulation of mRNA catabolic process (GO:0061014)2.81184820
142mature B cell differentiation involved in immune response (GO:0002313)2.80411062
143negative regulation of translation, ncRNA-mediated (GO:0040033)2.79715473
144regulation of translation, ncRNA-mediated (GO:0045974)2.79715473
145negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79715473
146positive regulation of interferon-alpha production (GO:0032727)2.78518864
147response to interleukin-15 (GO:0070672)2.78417542
148regulation of antigen processing and presentation (GO:0002577)2.77680648
149granulocyte activation (GO:0036230)2.77604845
150tachykinin receptor signaling pathway (GO:0007217)2.76965850
151negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.76174842
152NAD biosynthetic process (GO:0009435)2.75990680
153phosphatidylethanolamine biosynthetic process (GO:0006646)2.75711806
154lymph node development (GO:0048535)2.75699775
155histone H3-K9 methylation (GO:0051567)2.75662931
156regulation of Rab GTPase activity (GO:0032313)2.73508017
157positive regulation of Rab GTPase activity (GO:0032851)2.73508017
158thymic T cell selection (GO:0045061)2.70247517
159positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.69153346
160T-helper 1 type immune response (GO:0042088)2.67508137
161histone H3-K4 trimethylation (GO:0080182)2.66408220
162nucleosome disassembly (GO:0006337)2.64076965
163protein-DNA complex disassembly (GO:0032986)2.64076965
164B cell mediated immunity (GO:0019724)2.63260630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.53451797
2EZH2_22144423_ChIP-Seq_EOC_Human7.20514688
3MYC_22102868_ChIP-Seq_BL_Human5.39186392
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.94403152
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.29233850
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.26598917
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.12998673
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.87590292
9* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.65359542
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.44319269
11VDR_21846776_ChIP-Seq_THP-1_Human3.40418062
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.22161322
13* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.82975074
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.71277406
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.68596747
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58241793
17DROSHA_22980978_ChIP-Seq_HELA_Human2.54601864
18RUNX_20019798_ChIP-Seq_JUKART_Human2.52093174
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.42677452
20* MYB_26560356_Chip-Seq_TH2_Human2.42515161
21* MAF_26560356_Chip-Seq_TH1_Human2.42337161
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39393149
23UTX_26944678_Chip-Seq_JUKART_Human2.32564600
24* MYB_26560356_Chip-Seq_TH1_Human2.31868065
25CIITA_25753668_ChIP-Seq_RAJI_Human2.31680423
26IRF8_27001747_Chip-Seq_BMDM_Mouse2.30452768
27VDR_24763502_ChIP-Seq_THP-1_Human2.17066925
28TCF7_22412390_ChIP-Seq_EML_Mouse2.08965002
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.08827143
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.96079307
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95334241
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.90141621
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89130691
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86117650
35SCL_19346495_ChIP-Seq_HPC-7_Human1.82584738
36EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.82091197
37VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.80048225
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79256019
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76608216
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76229094
41KDM2B_26808549_Chip-Seq_DND41_Human1.75226015
42SPI1_23547873_ChIP-Seq_NB4_Human1.74066813
43LXR_22292898_ChIP-Seq_THP-1_Human1.73929111
44* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73478563
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72598108
46* BCL6_27268052_Chip-Seq_Bcells_Human1.70139373
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65891417
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.62463067
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61611162
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61591839
51* BCOR_27268052_Chip-Seq_Bcells_Human1.59860868
52NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.58349139
53SPI1_23127762_ChIP-Seq_K562_Human1.53966598
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52610247
55MAF_26560356_Chip-Seq_TH2_Human1.52042459
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51111791
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.49592198
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49253429
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49253429
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.48962869
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48377962
62AR_21572438_ChIP-Seq_LNCaP_Human1.42414493
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41918582
64GATA3_27048872_Chip-Seq_THYMUS_Human1.39460869
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37602031
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36795911
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35513278
68RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.35013597
69P68_20966046_ChIP-Seq_HELA_Human1.34823972
70* E2F1_20622854_ChIP-Seq_HELA_Human1.33607785
71SMC4_20622854_ChIP-Seq_HELA_Human1.31953667
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31134907
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30573986
74* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26205948
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24147549
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22409702
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21946663
78FOXP3_21729870_ChIP-Seq_TREG_Human1.20664203
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19439699
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18839490
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.18593730
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.18449009
83BP1_19119308_ChIP-ChIP_Hs578T_Human1.18381088
84* PHF8_20622854_ChIP-Seq_HELA_Human1.17663667
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16984563
86KDM5A_27292631_Chip-Seq_BREAST_Human1.16708561
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16376686
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12024499
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11131589
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10127109
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08862130
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08619177
93* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06719117
94GATA1_22025678_ChIP-Seq_K562_Human1.05248063
95BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.04694395
96TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01933757
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01845314
98YY1_22570637_ChIP-Seq_MALME-3M_Human1.01136483
99P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.00498911
100ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00055988
101OCT4_19829295_ChIP-Seq_ESCs_Human0.98837249
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98512378
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98049060
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97542959
105VDR_23849224_ChIP-Seq_CD4+_Human0.97478501
106PU_27001747_Chip-Seq_BMDM_Mouse0.96926143
107VDR_24787735_ChIP-Seq_THP-1_Human0.96911726
108ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96821052
109* OCT4_20526341_ChIP-Seq_ESCs_Human0.96597884
110ERA_21632823_ChIP-Seq_H3396_Human0.95497176
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95364793
112NCOR1_26117541_ChIP-Seq_K562_Human0.95128091
113WDR5_24793694_ChIP-Seq_LNCAP_Human0.95095140
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94933382
115KDM2B_26808549_Chip-Seq_JURKAT_Human0.94046157
116CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92887996
117TAF2_19829295_ChIP-Seq_ESCs_Human0.92544568
118TP63_22573176_ChIP-Seq_HFKS_Human0.91752691
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90313053
120REST_21632747_ChIP-Seq_MESCs_Mouse0.89744390
121RAC3_21632823_ChIP-Seq_H3396_Human0.89635690
122SPI1_20517297_ChIP-Seq_HL60_Human0.88831120
123RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88422566
124FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88183304
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88052036
126CEBPB_22108803_ChIP-Seq_LS180_Human0.85616266
127CTCF_27219007_Chip-Seq_Bcells_Human0.85181647
128* NANOG_20526341_ChIP-Seq_ESCs_Human0.85049935
129STAT1_20625510_ChIP-Seq_HELA_Human0.84850121
130E2F1_17053090_ChIP-ChIP_MCF-7_Human0.83982443
131CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81930365
132GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81141668
133FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.80954092
134KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77961127
135MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.77719867
136LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.77594127
137NOTCH1_21737748_ChIP-Seq_TLL_Human0.74746847
138SMRT_27268052_Chip-Seq_Bcells_Human0.74250982
139GATA1_19941827_ChIP-Seq_MEL_Mouse0.73653415
140GATA3_26560356_Chip-Seq_TH2_Human0.73156507
141MYC_19079543_ChIP-ChIP_MESCs_Mouse0.72336428
142* GATA3_26560356_Chip-Seq_TH1_Human0.72327402
143* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70265717
144PADI4_21655091_ChIP-ChIP_MCF-7_Human0.69257698
145CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68371234
146ETS1_22383799_ChIP-Seq_G1ME_Mouse0.67577831
147* P300_27268052_Chip-Seq_Bcells_Human0.67371685
148XRN2_22483619_ChIP-Seq_HELA_Human0.66631923
149KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.66239390
150ELK1_19687146_ChIP-ChIP_HELA_Human0.66171089
151PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.64739016
152DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.64699598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001800_abnormal_humoral_immune4.86530837
2MP0001835_abnormal_antigen_presentation4.50886687
3MP0001790_abnormal_immune_system4.27117415
4MP0005387_immune_system_phenotype4.27117415
5MP0003303_peritoneal_inflammation3.82962367
6MP0000685_abnormal_immune_system3.76537745
7* MP0002452_abnormal_antigen_presenting3.58350680
8MP0005645_abnormal_hypothalamus_physiol3.20066393
9MP0005671_abnormal_response_to3.06118291
10* MP0002398_abnormal_bone_marrow3.05596369
11* MP0002723_abnormal_immune_serum2.97535929
12MP0005423_abnormal_somatic_nervous2.95177539
13MP0005410_abnormal_fertilization2.94354699
14* MP0002420_abnormal_adaptive_immunity2.90159965
15MP0005000_abnormal_immune_tolerance2.89980951
16MP0001348_abnormal_lacrimal_gland2.82384823
17* MP0001819_abnormal_immune_cell2.81965648
18* MP0000689_abnormal_spleen_morphology2.77398687
19* MP0000716_abnormal_immune_system2.67413562
20MP0002396_abnormal_hematopoietic_system2.53533401
21MP0002166_altered_tumor_susceptibility2.40108553
22MP0006054_spinal_hemorrhage2.37318222
23MP0008057_abnormal_DNA_replication2.35374096
24* MP0002722_abnormal_immune_system2.35165560
25MP0003300_gastrointestinal_ulcer2.28355595
26MP0010094_abnormal_chromosome_stability2.27453561
27* MP0002429_abnormal_blood_cell2.21420158
28MP0003763_abnormal_thymus_physiology2.21391117
29MP0004808_abnormal_hematopoietic_stem2.17618283
30MP0005670_abnormal_white_adipose2.11616931
31MP0000703_abnormal_thymus_morphology2.02539420
32MP0002822_catalepsy1.98419539
33MP0003436_decreased_susceptibility_to1.90409210
34MP0001986_abnormal_taste_sensitivity1.82074498
35MP0005377_hearing/vestibular/ear_phenot1.77377386
36MP0003878_abnormal_ear_physiology1.77377386
37* MP0005025_abnormal_response_to1.76432984
38MP0010352_gastrointestinal_tract_polyps1.67344856
39MP0002735_abnormal_chemical_nociception1.66820806
40MP0009785_altered_susceptibility_to1.64552993
41MP0002006_tumorigenesis1.63984707
42MP0002405_respiratory_system_inflammati1.62178124
43MP0003077_abnormal_cell_cycle1.58590604
44MP0010155_abnormal_intestine_physiology1.55203226
45MP0003698_abnormal_male_reproductive1.53757463
46MP0002019_abnormal_tumor_incidence1.51833701
47MP0001845_abnormal_inflammatory_respons1.51035805
48MP0009046_muscle_twitch1.50994133
49MP0002148_abnormal_hypersensitivity_rea1.50498797
50MP0002419_abnormal_innate_immunity1.49289255
51MP0004947_skin_inflammation1.48989796
52MP0010234_abnormal_vibrissa_follicle1.48880261
53MP0001879_abnormal_lymphatic_vessel1.44666305
54MP0001853_heart_inflammation1.43853281
55MP0001929_abnormal_gametogenesis1.41907994
56MP0001873_stomach_inflammation1.38044086
57MP0003693_abnormal_embryo_hatching1.36414430
58MP0003866_abnormal_defecation1.31209689
59MP0009278_abnormal_bone_marrow1.26708878
60MP0003111_abnormal_nucleus_morphology1.25694638
61MP0002933_joint_inflammation1.25141875
62MP0005076_abnormal_cell_differentiation1.19775967
63MP0000465_gastrointestinal_hemorrhage1.17382670
64MP0003787_abnormal_imprinting1.11031396
65MP0004510_myositis1.09175464
66MP0005464_abnormal_platelet_physiology1.08382615
67MP0009333_abnormal_splenocyte_physiolog1.08267065
68MP0008995_early_reproductive_senescence1.07061914
69MP0000372_irregular_coat_pigmentation1.05915984
70MP0004957_abnormal_blastocyst_morpholog1.03700501
71MP0001501_abnormal_sleep_pattern1.01803045
72MP0000350_abnormal_cell_proliferation1.00810084
73MP0005310_abnormal_salivary_gland0.99374238
74MP0005397_hematopoietic_system_phenotyp0.98176553
75MP0001545_abnormal_hematopoietic_system0.98176553
76MP0002136_abnormal_kidney_physiology0.97352501
77MP0000490_abnormal_crypts_of0.97207102
78MP0003183_abnormal_peptide_metabolism0.95120233
79MP0010307_abnormal_tumor_latency0.92846629
80MP0002210_abnormal_sex_determination0.92405449
81MP0009115_abnormal_fat_cell0.91324612
82MP0008872_abnormal_physiological_respon0.89910298
83MP0008569_lethality_at_weaning0.89565352
84MP0009745_abnormal_behavioral_response0.89327851
85MP0001730_embryonic_growth_arrest0.88762235
86MP0008961_abnormal_basal_metabolism0.87974025
87MP0001905_abnormal_dopamine_level0.87606529
88MP0003091_abnormal_cell_migration0.86548128
89MP0002163_abnormal_gland_morphology0.83147358
90MP0002733_abnormal_thermal_nociception0.82348528
91MP0005220_abnormal_exocrine_pancreas0.82258712
92MP0008877_abnormal_DNA_methylation0.81302088
93MP0005451_abnormal_body_composition0.81030843
94MP0002693_abnormal_pancreas_physiology0.80836925
95MP0001765_abnormal_ion_homeostasis0.80012677
96MP0003566_abnormal_cell_adhesion0.79347528
97MP0001440_abnormal_grooming_behavior0.78655828
98MP0000313_abnormal_cell_death0.77921819
99MP0000470_abnormal_stomach_morphology0.76105642
100MP0002161_abnormal_fertility/fecundity0.75181230
101MP0004381_abnormal_hair_follicle0.73876750
102MP0005266_abnormal_metabolism0.72446362
103MP0005379_endocrine/exocrine_gland_phen0.71501247
104MP0002095_abnormal_skin_pigmentation0.70521538
105MP0004142_abnormal_muscle_tone0.69944790
106MP0000678_abnormal_parathyroid_gland0.69694380
107MP0001145_abnormal_male_reproductive0.68951389
108MP0005621_abnormal_cell_physiology0.68656716
109MP0003045_fibrosis0.67836415
110MP0008058_abnormal_DNA_repair0.67275041
111MP0001485_abnormal_pinna_reflex0.67017013
112MP0008469_abnormal_protein_level0.65910951
113MP0004145_abnormal_muscle_electrophysio0.65290300
114MP0000015_abnormal_ear_pigmentation0.64129949
115MP0002067_abnormal_sensory_capabilities0.62348659
116MP0009931_abnormal_skin_appearance0.61304944
117MP0002168_other_aberrant_phenotype0.61202339
118MP0001915_intracranial_hemorrhage0.60756596
119MP0000003_abnormal_adipose_tissue0.60687587
120MP0000653_abnormal_sex_gland0.59922666
121MP0008874_decreased_physiological_sensi0.59279619
122MP0002083_premature_death0.59143462
123MP0002928_abnormal_bile_duct0.57553439
124MP0002653_abnormal_ependyma_morphology0.56908464
125MP0001663_abnormal_digestive_system0.56405379
126MP0000249_abnormal_blood_vessel0.54957837
127MP0001533_abnormal_skeleton_physiology0.54483310
128MP0001944_abnormal_pancreas_morphology0.54222605
129MP0003984_embryonic_growth_retardation0.53971936
130MP0003453_abnormal_keratinocyte_physiol0.53771559
131MP0001970_abnormal_pain_threshold0.53224636
132MP0000013_abnormal_adipose_tissue0.52987785
133MP0002557_abnormal_social/conspecific_i0.52744601
134MP0004197_abnormal_fetal_growth/weight/0.52403133
135MP0002138_abnormal_hepatobiliary_system0.52068047
136MP0002088_abnormal_embryonic_growth/wei0.50042100
137MP0001784_abnormal_fluid_regulation0.50023428
138MP0002080_prenatal_lethality0.49626810
139MP0001919_abnormal_reproductive_system0.48422143
140MP0003646_muscle_fatigue0.47663680
141MP0001697_abnormal_embryo_size0.47557286
142MP0005384_cellular_phenotype0.46995334
143MP0000477_abnormal_intestine_morphology0.46733104
144MP0005380_embryogenesis_phenotype0.46247672
145MP0001672_abnormal_embryogenesis/_devel0.46247672
146MP0003828_pulmonary_edema0.46158963

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)9.47664511
2Cellulitis (HP:0100658)7.02657258
3Papilloma (HP:0012740)6.85227491
4Verrucae (HP:0200043)6.85227491
5Gastrointestinal stroma tumor (HP:0100723)6.12931939
6Recurrent sinusitis (HP:0011108)5.88968758
7Recurrent bronchitis (HP:0002837)5.70113244
8B lymphocytopenia (HP:0010976)5.69380325
9Abnormality of B cell number (HP:0010975)5.69380325
10Colitis (HP:0002583)5.19019007
11Genetic anticipation (HP:0003743)5.17003418
12Recurrent viral infections (HP:0004429)5.04740546
13Small epiphyses (HP:0010585)5.01660638
14Thyroiditis (HP:0100646)4.90868731
15Panhypogammaglobulinemia (HP:0003139)4.71745977
16Meningitis (HP:0001287)4.68160976
17Inflammation of the large intestine (HP:0002037)4.48932688
18Gastrointestinal inflammation (HP:0004386)4.41400139
19IgM deficiency (HP:0002850)4.35321930
20Recurrent pneumonia (HP:0006532)4.32455009
21Chronic sinusitis (HP:0011109)4.26441957
22Recurrent lower respiratory tract infections (HP:0002783)4.20264607
23Osteomyelitis (HP:0002754)4.18344836
24Lymphopenia (HP:0001888)4.15820560
25Abnormality of cells of the lymphoid lineage (HP:0012140)3.99666956
26IgG deficiency (HP:0004315)3.99558764
27Vertebral arch anomaly (HP:0008438)3.81720838
28Sepsis (HP:0100806)3.70237061
29Emphysema (HP:0002097)3.68499387
30Progressive cerebellar ataxia (HP:0002073)3.68189734
31IgA deficiency (HP:0002720)3.49431489
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.48346146
33Recurrent otitis media (HP:0000403)3.44509466
34Recurrent fungal infections (HP:0002841)3.35022367
35Mitral stenosis (HP:0001718)3.27359438
36Bronchiectasis (HP:0002110)3.24877651
37Vasculitis (HP:0002633)3.23878148
38Abnormality of the fingertips (HP:0001211)3.23433938
39Chronic otitis media (HP:0000389)3.23201356
40Bronchitis (HP:0012387)3.20309172
41Flattened epiphyses (HP:0003071)3.15275871
42Hypoplasia of the capital femoral epiphysis (HP:0003090)3.12455506
43T lymphocytopenia (HP:0005403)3.08542182
44Severe combined immunodeficiency (HP:0004430)3.02786179
45Abnormality of the intervertebral disk (HP:0005108)3.02608781
46Severe visual impairment (HP:0001141)2.97997576
47Abnormality of T cell number (HP:0011839)2.96351254
48Combined immunodeficiency (HP:0005387)2.93196049
49Restrictive lung disease (HP:0002091)2.90317480
50Dysmetric saccades (HP:0000641)2.88257170
51Abnormal ciliary motility (HP:0012262)2.76249663
52Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.76059910
53Hyperkalemia (HP:0002153)2.75330487
54Abnormality of T cells (HP:0002843)2.71083053
55Abnormality of binocular vision (HP:0011514)2.70434686
56Diplopia (HP:0000651)2.70434686
57Recurrent cutaneous fungal infections (HP:0011370)2.66696881
58Chronic mucocutaneous candidiasis (HP:0002728)2.66696881
59Ulnar bowing (HP:0003031)2.65639929
60Lymphoma (HP:0002665)2.63777515
61Chronic diarrhea (HP:0002028)2.61684715
62Skin rash (HP:0000988)2.59884802
63Chronic hepatic failure (HP:0100626)2.58759567
64Abnormal respiratory epithelium morphology (HP:0012253)2.56239652
65Abnormal respiratory motile cilium morphology (HP:0005938)2.56239652
66Hypoplasia of the thymus (HP:0000778)2.51453701
67Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.47821719
68Absent epiphyses (HP:0010577)2.47821719
69Hypoplastic ischia (HP:0003175)2.45620026
70Arthropathy (HP:0003040)2.41681369
71Irregular vertebral endplates (HP:0003301)2.41465491
72Impulsivity (HP:0100710)2.41270802
73Attenuation of retinal blood vessels (HP:0007843)2.39910751
74Abnormal respiratory motile cilium physiology (HP:0012261)2.38761508
75Volvulus (HP:0002580)2.38652296
76Leukopenia (HP:0001882)2.38579039
77Gaze-evoked nystagmus (HP:0000640)2.38272283
78Absent/shortened dynein arms (HP:0200106)2.38028423
79Dynein arm defect of respiratory motile cilia (HP:0012255)2.38028423
80Abnormality of T cell physiology (HP:0011840)2.34157923
81Mediastinal lymphadenopathy (HP:0100721)2.32060636
82Eosinophilia (HP:0001880)2.30586099
83Bony spicule pigmentary retinopathy (HP:0007737)2.28529497
84Autoimmune thrombocytopenia (HP:0001973)2.24604412
85Truncal obesity (HP:0001956)2.21813550
86Long eyelashes (HP:0000527)2.21721151
87Viral hepatitis (HP:0006562)2.20373168
88Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19487369
89Cutaneous melanoma (HP:0012056)2.18388931
90Limited elbow extension (HP:0001377)2.13721547
91Recurrent bacterial skin infections (HP:0005406)2.11407541
92Impaired smooth pursuit (HP:0007772)2.09968650
93Skin ulcer (HP:0200042)2.06855229
94Abnormality of the prostate (HP:0008775)2.05816095
95Neutropenia (HP:0001875)2.05471085
96Recurrent abscess formation (HP:0002722)2.04734228
97Poikiloderma (HP:0001029)2.03951877
98Recurrent skin infections (HP:0001581)2.01536077
99Aplasia/Hypoplasia of the thymus (HP:0010515)1.99538050
100Renovascular hypertension (HP:0100817)1.99329559
101Abnormality of the ischium (HP:0003174)1.97681868
102Retinal dysplasia (HP:0007973)1.97249109
103Basal cell carcinoma (HP:0002671)1.96650989
104Granulocytopenia (HP:0001913)1.94714018
105Prominent nose (HP:0000448)1.93751757
106Interstitial pulmonary disease (HP:0006530)1.93623442
107Rhinitis (HP:0012384)1.92899934
108Spontaneous hematomas (HP:0007420)1.92714523
109Increased IgE level (HP:0003212)1.92166226
110Vertebral clefting (HP:0008428)1.90958696
111Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89704332
112Chronic obstructive pulmonary disease (HP:0006510)1.89121230
113Obstructive lung disease (HP:0006536)1.89121230
114Bell-shaped thorax (HP:0001591)1.87998567
115Abnormality of eosinophils (HP:0001879)1.86829561
116Decreased circulating renin level (HP:0003351)1.85874751
117Abnormality of the nasal mucosa (HP:0000433)1.85373246
118Cutis marmorata (HP:0000965)1.84287491
119Abnormality of the thymus (HP:0000777)1.84237522
120Acute lymphatic leukemia (HP:0006721)1.82238228
121Encephalitis (HP:0002383)1.80960488
122Barrel-shaped chest (HP:0001552)1.80787977
123Clumsiness (HP:0002312)1.79254054
124Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.79078041
125Nasal polyposis (HP:0100582)1.77023324
126Abnormality of the vertebral endplates (HP:0005106)1.75892677
127Abnormality of the diencephalon (HP:0010662)1.75266120
128Thrombocytosis (HP:0001894)1.75252956
129Autoimmune hemolytic anemia (HP:0001890)1.72868406
130Protruding tongue (HP:0010808)1.71537535
131Abnormality of the pubic bones (HP:0003172)1.70807366
132Dehydration (HP:0001944)1.69733962
133Macroorchidism (HP:0000053)1.68927370
134Abnormality of DNA repair (HP:0003254)1.67735385
135Deep palmar crease (HP:0006191)1.65607388
136Abnormality of male internal genitalia (HP:0000022)1.64685255
137Papilledema (HP:0001085)1.64528512
138Ectopic kidney (HP:0000086)1.64157403
139Abnormality of the columella (HP:0009929)1.63443638
140Abnormality of the tricuspid valve (HP:0001702)1.59695118
141Pustule (HP:0200039)1.59633460
142Aortic regurgitation (HP:0001659)1.58762329
143Hematochezia (HP:0002573)1.56796575
144Aqueductal stenosis (HP:0002410)1.56682822
145Eczematoid dermatitis (HP:0000976)1.55436274
146Squamous cell carcinoma (HP:0002860)1.54501293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K106.67621246
2MAP4K15.51311988
3ERN14.13601105
4GRK63.54317489
5INSRR3.22564030
6EEF2K2.71057377
7SYK2.61232634
8BLK2.59098107
9CSF1R2.38321979
10PRPF4B2.35891696
11SMG12.26620634
12RIPK42.22526167
13STK102.21069634
14BTK2.17628543
15SIK22.09633723
16CDK122.03969243
17LRRK21.94007722
18ICK1.74002679
19NEK21.65096235
20PLK41.61773228
21NEK91.49856692
22CDC71.40208065
23LYN1.39194938
24PASK1.38195948
25CDK41.34227049
26STK41.31875745
27TRIB31.31532456
28DDR21.30519804
29PRKCH1.27319590
30EIF2AK31.27054240
31FRK1.22941454
32ZAK1.22192944
33CLK11.20526490
34HCK1.15808660
35TLK11.15136013
36TYK21.12778196
37FGFR31.11410662
38PIM11.10973004
39PKN21.10443621
40MAP3K91.09273106
41BMPR1B1.06182807
42MAP3K141.06072161
43MAP3K131.03608267
44PRKCQ1.03146631
45FES1.02764874
46BRD41.01651672
47ITK1.01116210
48SIK30.98249212
49JAK10.97032464
50MARK30.92001759
51MST40.90433700
52MAP2K20.90319377
53ACVR1B0.90170187
54CSK0.90031730
55LCK0.86930010
56CDK90.82849502
57FGFR20.81305639
58HIPK20.80826305
59RPS6KB20.80432125
60ZAP700.79563425
61TBK10.77234609
62TNK20.75711371
63RPS6KA40.74553837
64JAK30.73732163
65ALK0.72579521
66MAPK120.71972743
67IKBKB0.71095619
68TEC0.71024828
69MELK0.70586726
70SIK10.69693426
71CAMK1G0.68738164
72MAPK70.66802720
73WNK10.66123406
74TAF10.64950472
75PIK3CG0.64537584
76VRK10.63468553
77MAPK110.62518264
78CHEK10.61257475
79MAP3K80.60854024
80NLK0.60356702
81DYRK1B0.59738158
82MAPK40.59049656
83MAP3K70.58971906
84MAPK150.58108650
85CAMK1D0.58001838
86CDK70.56904188
87CDK60.56531766
88PRKD10.54456616
89RPS6KA60.54353880
90ATR0.53747323
91CSNK1D0.53633717
92SCYL20.53333895
93PRKD20.52421893
94RPS6KB10.52262787
95PDPK10.52179560
96CAMKK10.52040938
97KIT0.50634906
98PRKCI0.50356822
99TESK20.49587209
100TAOK30.48618105
101PDK10.47730074
102MTOR0.47565748
103MATK0.45318377
104FGFR40.44603447
105TESK10.40712966
106MAPKAPK20.40023394
107CHUK0.39846984
108RPS6KA50.39117984
109STK30.38099705
110RPS6KL10.38034607
111RPS6KC10.38034607
112CDK80.37732184
113IKBKE0.37550188
114FYN0.37409013
115STK38L0.37078189
116SGK30.36682308
117DYRK30.36635544
118CHEK20.36534239
119INSR0.36148710
120TGFBR20.35901531
121AURKB0.35279126
122CCNB10.35278067
123ABL10.35241265
124CDC42BPA0.35006092
125PKN10.33453272
126STK240.33393054
127CDK20.33328961
128TGFBR10.33090291
129SGK20.32706185
130EGFR0.31624525
131PRKAA10.31437427
132IRAK40.30902955
133GSK3B0.30255214
134SGK4940.29973867
135SGK2230.29973867
136MAP2K10.26663271
137PRKCD0.25250908
138MARK20.24971747

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.98596128
2B cell receptor signaling pathway_Homo sapiens_hsa046625.59943557
3Autoimmune thyroid disease_Homo sapiens_hsa053203.91908360
4Asthma_Homo sapiens_hsa053103.76256607
5Graft-versus-host disease_Homo sapiens_hsa053323.76088098
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.36062413
7Type I diabetes mellitus_Homo sapiens_hsa049403.29576406
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.76877334
9Non-homologous end-joining_Homo sapiens_hsa034502.61429760
10Base excision repair_Homo sapiens_hsa034102.21983377
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.19542194
12Osteoclast differentiation_Homo sapiens_hsa043801.90179906
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.88957792
14Hematopoietic cell lineage_Homo sapiens_hsa046401.83998927
15DNA replication_Homo sapiens_hsa030301.80264134
16Mismatch repair_Homo sapiens_hsa034301.77292348
17Antigen processing and presentation_Homo sapiens_hsa046121.68030600
18Non-small cell lung cancer_Homo sapiens_hsa052231.57763224
19Staphylococcus aureus infection_Homo sapiens_hsa051501.57319388
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55043261
21T cell receptor signaling pathway_Homo sapiens_hsa046601.54200149
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53666661
23Systemic lupus erythematosus_Homo sapiens_hsa053221.53058345
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49885883
25Chronic myeloid leukemia_Homo sapiens_hsa052201.38533163
26Leishmaniasis_Homo sapiens_hsa051401.38217946
27Viral carcinogenesis_Homo sapiens_hsa052031.36254932
28Measles_Homo sapiens_hsa051621.32169912
29Herpes simplex infection_Homo sapiens_hsa051681.30072616
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.27911890
31Epstein-Barr virus infection_Homo sapiens_hsa051691.22489684
32Hepatitis B_Homo sapiens_hsa051611.19289454
33Pancreatic cancer_Homo sapiens_hsa052121.14680590
34Chemokine signaling pathway_Homo sapiens_hsa040621.12925058
35HTLV-I infection_Homo sapiens_hsa051661.11706604
36Tuberculosis_Homo sapiens_hsa051521.10161503
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.05753595
38Butanoate metabolism_Homo sapiens_hsa006501.03749415
39Cell cycle_Homo sapiens_hsa041101.03004081
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01361652
41Acute myeloid leukemia_Homo sapiens_hsa052211.00276024
42Glioma_Homo sapiens_hsa052141.00121887
43Neurotrophin signaling pathway_Homo sapiens_hsa047220.98558257
44Platelet activation_Homo sapiens_hsa046110.97063097
45Taste transduction_Homo sapiens_hsa047420.96688332
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94630916
47Spliceosome_Homo sapiens_hsa030400.94179544
48MicroRNAs in cancer_Homo sapiens_hsa052060.93433603
49Shigellosis_Homo sapiens_hsa051310.90526388
50Apoptosis_Homo sapiens_hsa042100.89479096
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86722904
52Alcoholism_Homo sapiens_hsa050340.86072020
53Lysine degradation_Homo sapiens_hsa003100.84706908
54Toxoplasmosis_Homo sapiens_hsa051450.83292992
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.82831694
56Small cell lung cancer_Homo sapiens_hsa052220.82580244
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81668914
58Notch signaling pathway_Homo sapiens_hsa043300.81436924
59mRNA surveillance pathway_Homo sapiens_hsa030150.79602236
60Influenza A_Homo sapiens_hsa051640.79446931
61FoxO signaling pathway_Homo sapiens_hsa040680.78692191
62Homologous recombination_Homo sapiens_hsa034400.78017418
63mTOR signaling pathway_Homo sapiens_hsa041500.75934973
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73857099
65Morphine addiction_Homo sapiens_hsa050320.72660502
66Ribosome_Homo sapiens_hsa030100.72203029
67Inositol phosphate metabolism_Homo sapiens_hsa005620.71692980
68Cholinergic synapse_Homo sapiens_hsa047250.71383375
69VEGF signaling pathway_Homo sapiens_hsa043700.70778210
70p53 signaling pathway_Homo sapiens_hsa041150.70331377
71Prostate cancer_Homo sapiens_hsa052150.69764485
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69569668
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68116125
74Fanconi anemia pathway_Homo sapiens_hsa034600.66697664
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66466678
76Viral myocarditis_Homo sapiens_hsa054160.64076628
77Rheumatoid arthritis_Homo sapiens_hsa053230.63521739
78Fatty acid biosynthesis_Homo sapiens_hsa000610.62880825
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60173446
80Colorectal cancer_Homo sapiens_hsa052100.60120327
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.59950831
82Insulin resistance_Homo sapiens_hsa049310.59877707
83Nicotine addiction_Homo sapiens_hsa050330.59855702
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58551254
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57233233
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57036217
87Olfactory transduction_Homo sapiens_hsa047400.56959058
88Nucleotide excision repair_Homo sapiens_hsa034200.54807352
89ABC transporters_Homo sapiens_hsa020100.52944565
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52001685
91RNA transport_Homo sapiens_hsa030130.51265585
92TNF signaling pathway_Homo sapiens_hsa046680.49900491
93Renal cell carcinoma_Homo sapiens_hsa052110.49683561
94MAPK signaling pathway_Homo sapiens_hsa040100.49563150
95African trypanosomiasis_Homo sapiens_hsa051430.48023738
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47304491
97Hepatitis C_Homo sapiens_hsa051600.47197337
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46863984
99Selenocompound metabolism_Homo sapiens_hsa004500.42153241
100Malaria_Homo sapiens_hsa051440.41369082
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.40907509
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.40608698
103Proteoglycans in cancer_Homo sapiens_hsa052050.40022255
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39949299
105Serotonergic synapse_Homo sapiens_hsa047260.39554335
106Pertussis_Homo sapiens_hsa051330.37034332
107GABAergic synapse_Homo sapiens_hsa047270.36379932
108RNA degradation_Homo sapiens_hsa030180.35773867
109HIF-1 signaling pathway_Homo sapiens_hsa040660.35620323
110Calcium signaling pathway_Homo sapiens_hsa040200.34353322
111Choline metabolism in cancer_Homo sapiens_hsa052310.34300233
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34014058
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33915454
114Long-term potentiation_Homo sapiens_hsa047200.33687247
115Salmonella infection_Homo sapiens_hsa051320.32562922
116Endocytosis_Homo sapiens_hsa041440.32289050
117Endometrial cancer_Homo sapiens_hsa052130.31648268
118ErbB signaling pathway_Homo sapiens_hsa040120.30991828
119Allograft rejection_Homo sapiens_hsa053300.30493144
120Legionellosis_Homo sapiens_hsa051340.30458405
121Phototransduction_Homo sapiens_hsa047440.30029468
122Prolactin signaling pathway_Homo sapiens_hsa049170.29935945
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29890900
124Type II diabetes mellitus_Homo sapiens_hsa049300.29507538
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28326971
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.28091812
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27379193
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27128946
129Dorso-ventral axis formation_Homo sapiens_hsa043200.26457814
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26337216
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25742145
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25284126
133Pathways in cancer_Homo sapiens_hsa052000.24245216
134Estrogen signaling pathway_Homo sapiens_hsa049150.23713797
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21709258

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