POU2F1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.40715603
2negative regulation of histone methylation (GO:0031061)4.67019099
3mitotic sister chromatid cohesion (GO:0007064)4.56658084
4regulation of histone H3-K9 methylation (GO:0051570)4.55226944
5nuclear pore complex assembly (GO:0051292)4.30233218
6DNA methylation (GO:0006306)3.98898284
7DNA alkylation (GO:0006305)3.98898284
8nuclear pore organization (GO:0006999)3.90491627
9tRNA methylation (GO:0030488)3.73063225
10negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.72240893
11negative regulation of translation, ncRNA-mediated (GO:0040033)3.72240893
12regulation of translation, ncRNA-mediated (GO:0045974)3.72240893
13regulation of DNA endoreduplication (GO:0032875)3.66688368
14histone H3-K4 methylation (GO:0051568)3.58351033
15kinetochore organization (GO:0051383)3.55856293
16presynaptic membrane assembly (GO:0097105)3.54486891
17regulation of gene expression by genetic imprinting (GO:0006349)3.53110720
18histone lysine demethylation (GO:0070076)3.51008808
19DNA methylation or demethylation (GO:0044728)3.50481353
20histone H3-K9 modification (GO:0061647)3.46234561
21regulation of helicase activity (GO:0051095)3.45227557
22DNA unwinding involved in DNA replication (GO:0006268)3.41856782
23pyrimidine nucleobase catabolic process (GO:0006208)3.35653131
24CENP-A containing nucleosome assembly (GO:0034080)3.34024046
25histone demethylation (GO:0016577)3.32348010
26histone H3-K4 trimethylation (GO:0080182)3.31603945
27DNA methylation involved in gamete generation (GO:0043046)3.28967643
28regulation of RNA export from nucleus (GO:0046831)3.28125234
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.24784697
30regulation of histone methylation (GO:0031060)3.23218767
31regulation of gene silencing by miRNA (GO:0060964)3.22549067
32regulation of gene silencing by RNA (GO:0060966)3.22549067
33regulation of posttranscriptional gene silencing (GO:0060147)3.22549067
34histone H4-K12 acetylation (GO:0043983)3.19508819
35sister chromatid cohesion (GO:0007062)3.15096568
36mitotic chromosome condensation (GO:0007076)3.14186195
37pore complex assembly (GO:0046931)3.12597919
38chromatin assembly (GO:0031497)3.11107158
39regulation of DNA methylation (GO:0044030)3.10300377
40kinetochore assembly (GO:0051382)3.10226537
41regulation of histone H3-K27 methylation (GO:0061085)3.09838392
42histone exchange (GO:0043486)3.09253160
43DNA geometric change (GO:0032392)3.08525918
44DNA duplex unwinding (GO:0032508)3.08510211
45N-terminal protein amino acid acetylation (GO:0006474)3.04172074
46histone H3-K9 methylation (GO:0051567)3.03593464
47presynaptic membrane organization (GO:0097090)3.02972653
48regulation of histone H3-K4 methylation (GO:0051569)3.01815882
49interkinetic nuclear migration (GO:0022027)3.01801845
50regulation of gene silencing (GO:0060968)3.00445247
51histone H3-K36 demethylation (GO:0070544)3.00260211
52microtubule depolymerization (GO:0007019)2.98400451
53DNA modification (GO:0006304)2.96453877
54histone lysine methylation (GO:0034968)2.96260180
55protein dealkylation (GO:0008214)2.95382991
56protein demethylation (GO:0006482)2.95382991
57regulation of chromatin silencing (GO:0031935)2.95243055
58behavioral response to nicotine (GO:0035095)2.93730249
59determination of adult lifespan (GO:0008340)2.93537212
60regulation of sister chromatid cohesion (GO:0007063)2.90852537
61histone H4-K16 acetylation (GO:0043984)2.88888139
62DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.88203061
63peptidyl-lysine trimethylation (GO:0018023)2.87270339
64meiotic chromosome segregation (GO:0045132)2.86358883
65negative regulation of DNA-dependent DNA replication (GO:2000104)2.85828291
66sister chromatid segregation (GO:0000819)2.85706316
67histone H4-K5 acetylation (GO:0043981)2.85616876
68histone H4-K8 acetylation (GO:0043982)2.85616876
69protein-DNA complex disassembly (GO:0032986)2.85205046
70nucleosome disassembly (GO:0006337)2.85205046
71positive regulation of gene expression, epigenetic (GO:0045815)2.83186291
72centriole replication (GO:0007099)2.83168070
73paraxial mesoderm development (GO:0048339)2.82770166
74ncRNA catabolic process (GO:0034661)2.82137440
75mitotic nuclear envelope disassembly (GO:0007077)2.82085457
76histone methylation (GO:0016571)2.81327435
77DNA replication-dependent nucleosome assembly (GO:0006335)2.79064195
78DNA replication-dependent nucleosome organization (GO:0034723)2.79064195
79protein localization to kinetochore (GO:0034501)2.78375952
80mRNA splice site selection (GO:0006376)2.77363673
81cell proliferation in forebrain (GO:0021846)2.76495542
82positive regulation of histone methylation (GO:0031062)2.75249902
83regulation of centriole replication (GO:0046599)2.73817077
84negative regulation of chromatin modification (GO:1903309)2.73711019
85regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.73536818
86regulation of mitotic spindle checkpoint (GO:1903504)2.73536818
87chromatin assembly or disassembly (GO:0006333)2.73153624
88ATP-dependent chromatin remodeling (GO:0043044)2.72933233
89dorsal/ventral axis specification (GO:0009950)2.72695582
90somite development (GO:0061053)2.72059023
91resolution of meiotic recombination intermediates (GO:0000712)2.71641011
92neuronal stem cell maintenance (GO:0097150)2.71545969
93DNA replication checkpoint (GO:0000076)2.71081855
94somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70640544
95somatic hypermutation of immunoglobulin genes (GO:0016446)2.70640544
96DNA replication-independent nucleosome organization (GO:0034724)2.70390523
97DNA replication-independent nucleosome assembly (GO:0006336)2.70390523
98DNA double-strand break processing (GO:0000729)2.70301687
99genetic imprinting (GO:0071514)2.69830561
100cytoplasmic mRNA processing body assembly (GO:0033962)2.69598696
101limb bud formation (GO:0060174)2.68978986
102replication fork processing (GO:0031297)2.68570388
103regulation of nuclear cell cycle DNA replication (GO:0033262)2.68027441
104DNA topological change (GO:0006265)2.67833314
105chromatin silencing (GO:0006342)2.67560227
106negative regulation of histone modification (GO:0031057)2.66969461
107synapsis (GO:0007129)2.65138987
108kidney morphogenesis (GO:0060993)2.63102685
109neural tube formation (GO:0001841)2.61889444
110intra-S DNA damage checkpoint (GO:0031573)2.60356576
111positive regulation of chromosome segregation (GO:0051984)2.60242599
112membrane disassembly (GO:0030397)2.59872876
113nuclear envelope disassembly (GO:0051081)2.59872876
114mitotic sister chromatid segregation (GO:0000070)2.59192653
115neuron cell-cell adhesion (GO:0007158)2.58902511
116negative regulation of DNA recombination (GO:0045910)2.58631035
117positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.58210601
118positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.58210601
119positive regulation of mitotic sister chromatid separation (GO:1901970)2.58210601
120heterochromatin organization (GO:0070828)2.58185031
121regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.57186276
122positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.57186276
123positive regulation of histone H3-K4 methylation (GO:0051571)2.57146399
124hindbrain development (GO:0030902)2.57064278
125microtubule anchoring (GO:0034453)2.56983183
126negative regulation of RNA splicing (GO:0033119)2.56908783
127protein localization to chromosome, centromeric region (GO:0071459)2.56258809
128gene silencing by RNA (GO:0031047)2.55158319
129chromatin remodeling at centromere (GO:0031055)2.54735008
130DNA conformation change (GO:0071103)2.54452260
131monoubiquitinated protein deubiquitination (GO:0035520)2.52326565
132forebrain neuron differentiation (GO:0021879)2.48861862
133otic vesicle formation (GO:0030916)2.46836478
134positive regulation of mRNA processing (GO:0050685)2.45782153
135postsynaptic membrane organization (GO:0001941)2.43444568
136spindle checkpoint (GO:0031577)2.43344811
137nucleobase catabolic process (GO:0046113)2.41103538
138negative regulation of sister chromatid segregation (GO:0033046)2.40126537
139negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.40126537
140negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.40126537
141negative regulation of mitotic sister chromatid segregation (GO:0033048)2.40126537
142negative regulation of mitotic sister chromatid separation (GO:2000816)2.40126537
143negative regulation of chromosome segregation (GO:0051985)2.39981337
144atrial cardiac muscle cell action potential (GO:0086014)2.38287850
145negative regulation of gene silencing (GO:0060969)2.38055844
146somite rostral/caudal axis specification (GO:0032525)2.37055709
147regulation of centrosome cycle (GO:0046605)2.36700213
148regulation of non-canonical Wnt signaling pathway (GO:2000050)2.36379639
149mitotic spindle checkpoint (GO:0071174)2.36192885
150maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.34735285
151regulation of stem cell maintenance (GO:2000036)2.33458984
152nonmotile primary cilium assembly (GO:0035058)2.33169402
153regulation of telomere maintenance (GO:0032204)2.30016451
154regulation of mitotic sister chromatid separation (GO:0010965)2.29671081
155regulation of mitotic sister chromatid segregation (GO:0033047)2.29671081
156regulation of sister chromatid segregation (GO:0033045)2.29671081
157non-recombinational repair (GO:0000726)2.28502112
158double-strand break repair via nonhomologous end joining (GO:0006303)2.28502112

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.87648159
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.92707432
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.29344763
4EZH2_22144423_ChIP-Seq_EOC_Human4.09588089
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.66372806
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.20400170
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.06242371
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.04591136
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92524552
10ZNF274_21170338_ChIP-Seq_K562_Hela2.50326857
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.48912528
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.23220837
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.23220837
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.23220837
15GBX2_23144817_ChIP-Seq_PC3_Human2.20275043
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19701690
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.15508430
18IGF1R_20145208_ChIP-Seq_DFB_Human2.14700208
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.14039143
20TAF15_26573619_Chip-Seq_HEK293_Human2.11611893
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.08657870
22VDR_22108803_ChIP-Seq_LS180_Human1.98661645
23SOX2_18555785_ChIP-Seq_MESCs_Mouse1.95721411
24CIITA_25753668_ChIP-Seq_RAJI_Human1.94597079
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88584672
26MYC_22102868_ChIP-Seq_BL_Human1.86132312
27P300_19829295_ChIP-Seq_ESCs_Human1.84841159
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83986659
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79055781
30* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78840389
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.78444565
32SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.76904973
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76317416
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70157439
35* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.69439472
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68848824
37TCF3_18692474_ChIP-Seq_MESCs_Mouse1.67913842
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67606850
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64576962
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61934775
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.60128144
42AR_21572438_ChIP-Seq_LNCaP_Human1.57656628
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55586849
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55120821
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45685509
46FUS_26573619_Chip-Seq_HEK293_Human1.45593021
47RNF2_27304074_Chip-Seq_NSC_Mouse1.43976507
48* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43722334
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.43690981
50* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43640115
51* SOX2_16153702_ChIP-ChIP_HESCs_Human1.39502145
52* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39441166
53* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36499359
54* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.35058812
55SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.33323697
56EWS_26573619_Chip-Seq_HEK293_Human1.33097585
57TCF3_18692474_ChIP-Seq_MEFs_Mouse1.32842030
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.31586885
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.29993347
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29261533
61* NANOG_16153702_ChIP-ChIP_HESCs_Human1.28942480
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28929267
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.28576342
64STAT3_23295773_ChIP-Seq_U87_Human1.28559081
65SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.28215800
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25192807
67SMAD4_21799915_ChIP-Seq_A2780_Human1.24949504
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24662022
69* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.24020670
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.23550935
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21344656
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21168466
73* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20803110
74ER_23166858_ChIP-Seq_MCF-7_Human1.20031299
75ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19428790
76REST_21632747_ChIP-Seq_MESCs_Mouse1.17993718
77GATA1_26923725_Chip-Seq_HPCs_Mouse1.17726433
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17175996
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16883496
80* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16817541
81TCF4_23295773_ChIP-Seq_U87_Human1.16357442
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15830182
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15824525
84SOX9_26525672_Chip-Seq_HEART_Mouse1.15378362
85TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14870492
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14797523
87* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.13896531
88* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13219859
89TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13113635
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12532553
91CBP_20019798_ChIP-Seq_JUKART_Human1.12532553
92KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11232163
93SCL_19346495_ChIP-Seq_HPC-7_Human1.10445236
94IRF1_19129219_ChIP-ChIP_H3396_Human1.10163254
95NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09425415
96STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08667979
97POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07409466
98EZH2_27304074_Chip-Seq_ESCs_Mouse1.05676948
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05643289
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04830081
101RUNX2_22187159_ChIP-Seq_PCA_Human1.04706293
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04509786
103* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01455125
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00644893
105* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00181696
106NOTCH1_21737748_ChIP-Seq_TLL_Human0.99884690
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99836918
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99382557
109AR_21909140_ChIP-Seq_LNCAP_Human0.99252159
110* CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97876516
111TCF4_18268006_ChIP-ChIP_LS174T_Human0.97378232
112FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96522800
113NELFA_20434984_ChIP-Seq_ESCs_Mouse0.96383999
114FLI1_27457419_Chip-Seq_LIVER_Mouse0.95189111
115* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95176519
116SMAD3_21741376_ChIP-Seq_ESCs_Human0.94578640
117PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94273890
118* AR_25329375_ChIP-Seq_VCAP_Human0.93971176
119BCAT_22108803_ChIP-Seq_LS180_Human0.93342991
120NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93239895
121* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93059199
122HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92707798
123* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92287910
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92152673
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92152673
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92116525
127RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91754907
128NANOG_21062744_ChIP-ChIP_HESCs_Human0.91509854
129TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91241221
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91183504
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90218769
132* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90138172
133VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88547713
134* KDM5A_27292631_Chip-Seq_BREAST_Human0.88063095
135GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86746603
136MYC_18940864_ChIP-ChIP_HL60_Human0.85629845
137ISL1_27105846_Chip-Seq_CPCs_Mouse0.85515167
138* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85179580
139ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84000640
140* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83982261
141* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83918662
142ELK1_19687146_ChIP-ChIP_HELA_Human0.82604822
143PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81062903
144FOXP3_21729870_ChIP-Seq_TREG_Human0.80889721
145* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.79689321
146TCF7_22412390_ChIP-Seq_EML_Mouse0.79010359
147* TTF2_22483619_ChIP-Seq_HELA_Human0.78736800
148PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78521351
149SOX2_18692474_ChIP-Seq_MESCs_Mouse0.78015126
150* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.76570813
151MYB_26560356_Chip-Seq_TH1_Human0.76223434
152* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.75314944
153ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.73658294
154STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.73322685

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.01571936
2MP0008057_abnormal_DNA_replication3.62547246
3MP0010094_abnormal_chromosome_stability3.44370489
4MP0008058_abnormal_DNA_repair2.80862948
5MP0003111_abnormal_nucleus_morphology2.69991820
6MP0003077_abnormal_cell_cycle2.52153820
7MP0003121_genomic_imprinting2.47776682
8MP0008877_abnormal_DNA_methylation2.46473556
9MP0003123_paternal_imprinting2.39202581
10MP0004510_myositis2.34023883
11MP0008007_abnormal_cellular_replicative2.00634276
12MP0003693_abnormal_embryo_hatching1.99596302
13MP0005174_abnormal_tail_pigmentation1.99313568
14MP0004957_abnormal_blastocyst_morpholog1.93342621
15* MP0006292_abnormal_olfactory_placode1.88603424
16MP0003787_abnormal_imprinting1.74443027
17MP0005409_darkened_coat_color1.74351432
18* MP0001293_anophthalmia1.71332263
19MP0002396_abnormal_hematopoietic_system1.69238144
20MP0004808_abnormal_hematopoietic_stem1.65983496
21MP0006072_abnormal_retinal_apoptosis1.64177957
22MP0001188_hyperpigmentation1.60241530
23MP0000350_abnormal_cell_proliferation1.55258078
24MP0000566_synostosis1.53232040
25MP0002084_abnormal_developmental_patter1.51817869
26* MP0003890_abnormal_embryonic-extraembry1.49049968
27MP0002009_preneoplasia1.47346933
28MP0010030_abnormal_orbit_morphology1.42537939
29MP0002085_abnormal_embryonic_tissue1.41207569
30MP0003937_abnormal_limbs/digits/tail_de1.40072978
31MP0010352_gastrointestinal_tract_polyps1.39413592
32MP0003122_maternal_imprinting1.37338603
33MP0003880_abnormal_central_pattern1.36907802
34MP0003136_yellow_coat_color1.35119135
35MP0002233_abnormal_nose_morphology1.34493438
36* MP0001672_abnormal_embryogenesis/_devel1.32702940
37* MP0005380_embryogenesis_phenotype1.32702940
38MP0002938_white_spotting1.30426547
39MP0000015_abnormal_ear_pigmentation1.27039559
40MP0010307_abnormal_tumor_latency1.25052247
41MP0009697_abnormal_copulation1.24960672
42MP0008932_abnormal_embryonic_tissue1.24271704
43MP0009703_decreased_birth_body1.22532432
44MP0002822_catalepsy1.21227139
45* MP0001730_embryonic_growth_arrest1.18885254
46MP0002166_altered_tumor_susceptibility1.18832410
47MP0000703_abnormal_thymus_morphology1.18570710
48MP0004197_abnormal_fetal_growth/weight/1.18410483
49MP0001529_abnormal_vocalization1.18225960
50MP0003861_abnormal_nervous_system1.17731175
51MP0002210_abnormal_sex_determination1.16807052
52MP0002751_abnormal_autonomic_nervous1.16152023
53* MP0001286_abnormal_eye_development1.15945609
54MP0003786_premature_aging1.15773069
55MP0002249_abnormal_larynx_morphology1.15245419
56MP0004133_heterotaxia1.15081102
57MP0003984_embryonic_growth_retardation1.14008504
58* MP0001697_abnormal_embryo_size1.13731704
59MP0002653_abnormal_ependyma_morphology1.13439594
60MP0000955_abnormal_spinal_cord1.12875552
61* MP0002152_abnormal_brain_morphology1.12701291
62MP0002088_abnormal_embryonic_growth/wei1.12630884
63MP0000432_abnormal_head_morphology1.10117710
64MP0003935_abnormal_craniofacial_develop1.09954510
65MP0002184_abnormal_innervation1.09674162
66MP0005187_abnormal_penis_morphology1.09584355
67MP0003878_abnormal_ear_physiology1.08644773
68MP0005377_hearing/vestibular/ear_phenot1.08644773
69MP0003567_abnormal_fetal_cardiomyocyte1.08279585
70MP0003119_abnormal_digestive_system1.07308975
71MP0004142_abnormal_muscle_tone1.06992294
72MP0005076_abnormal_cell_differentiation1.06928939
73MP0002095_abnormal_skin_pigmentation1.05648177
74MP0006276_abnormal_autonomic_nervous1.05640097
75MP0002006_tumorigenesis1.05436921
76* MP0005391_vision/eye_phenotype1.05216418
77MP0001984_abnormal_olfaction1.04875325
78MP0003763_abnormal_thymus_physiology1.03957377
79MP0002557_abnormal_social/conspecific_i1.03734600
80* MP0002086_abnormal_extraembryonic_tissu1.02736572
81MP0005253_abnormal_eye_physiology1.02399049
82MP0002102_abnormal_ear_morphology1.02147038
83MP0001486_abnormal_startle_reflex1.01609008
84MP0000049_abnormal_middle_ear1.01057359
85MP0002160_abnormal_reproductive_system1.00740174
86MP0002075_abnormal_coat/hair_pigmentati0.98178702
87MP0002752_abnormal_somatic_nervous0.97961609
88MP0001299_abnormal_eye_distance/0.96862756
89MP0003635_abnormal_synaptic_transmissio0.96777489
90* MP0002092_abnormal_eye_morphology0.96583522
91MP0002234_abnormal_pharynx_morphology0.96440717
92MP0001145_abnormal_male_reproductive0.96224810
93MP0002398_abnormal_bone_marrow0.95526606
94MP0004381_abnormal_hair_follicle0.95132927
95MP0001929_abnormal_gametogenesis0.94925178
96MP0009046_muscle_twitch0.94300485
97* MP0002697_abnormal_eye_size0.93584528
98MP0000428_abnormal_craniofacial_morphol0.92795922
99MP0004742_abnormal_vestibular_system0.92214127
100MP0000647_abnormal_sebaceous_gland0.91504619
101MP0002063_abnormal_learning/memory/cond0.91266724
102MP0002272_abnormal_nervous_system0.90312752
103MP0005499_abnormal_olfactory_system0.90247041
104MP0005394_taste/olfaction_phenotype0.90247041
105MP0003698_abnormal_male_reproductive0.90226885
106MP0002638_abnormal_pupillary_reflex0.90216561
107MP0005645_abnormal_hypothalamus_physiol0.90001327
108* MP0002080_prenatal_lethality0.89702979
109MP0008789_abnormal_olfactory_epithelium0.89644398
110MP0001800_abnormal_humoral_immune0.89504046
111MP0002736_abnormal_nociception_after0.89221413
112MP0009672_abnormal_birth_weight0.88909343
113MP0003718_maternal_effect0.88710294
114MP0005195_abnormal_posterior_eye0.88081110
115MP0004270_analgesia0.87975559
116MP0001485_abnormal_pinna_reflex0.87844561
117MP0002882_abnormal_neuron_morphology0.86920281
118* MP0000631_abnormal_neuroendocrine_gland0.86456921
119MP0009379_abnormal_foot_pigmentation0.86096266
120MP0004147_increased_porphyrin_level0.85816260
121MP0005551_abnormal_eye_electrophysiolog0.84215836
122MP0003755_abnormal_palate_morphology0.83933302
123MP0004885_abnormal_endolymph0.83737625
124MP0000653_abnormal_sex_gland0.83018671
125MP0000383_abnormal_hair_follicle0.82494283
126MP0000537_abnormal_urethra_morphology0.82093917
127MP0003938_abnormal_ear_development0.81123376
128MP0000490_abnormal_crypts_of0.81027288
129MP0001919_abnormal_reproductive_system0.80488246
130MP0002116_abnormal_craniofacial_bone0.79974803
131MP0000778_abnormal_nervous_system0.79471406
132MP0008995_early_reproductive_senescence0.78818471
133MP0000313_abnormal_cell_death0.78365455
134MP0002925_abnormal_cardiovascular_devel0.77653120
135MP0003941_abnormal_skin_development0.77601862
136MP0002114_abnormal_axial_skeleton0.77355471

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.36828250
2Septo-optic dysplasia (HP:0100842)3.26693329
3Abnormality of the fingertips (HP:0001211)3.22636015
4Chromsome breakage (HP:0040012)3.06395968
5Increased nuchal translucency (HP:0010880)2.94309401
6Chromosomal breakage induced by crosslinking agents (HP:0003221)2.91098735
7Medulloblastoma (HP:0002885)2.88852059
8Aplasia/Hypoplasia of the uvula (HP:0010293)2.80902963
9Supernumerary ribs (HP:0005815)2.74926731
10Abnormality of chromosome stability (HP:0003220)2.74359564
11Abnormal number of incisors (HP:0011064)2.71716218
12Bilateral microphthalmos (HP:0007633)2.66142216
13Supernumerary bones of the axial skeleton (HP:0009144)2.63718033
14Long eyelashes (HP:0000527)2.63424007
15Meckel diverticulum (HP:0002245)2.59282770
16Abnormality of the carotid arteries (HP:0005344)2.56812453
17Anal stenosis (HP:0002025)2.55858625
18Neoplasm of the oral cavity (HP:0100649)2.54248532
19Ectopic kidney (HP:0000086)2.53387493
20Pancreatic cysts (HP:0001737)2.52809341
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.51388183
22Short 4th metacarpal (HP:0010044)2.51388183
23Hepatoblastoma (HP:0002884)2.50508986
24Supernumerary spleens (HP:0009799)2.50150392
25Abnormality of the ileum (HP:0001549)2.48208580
26Abnormality of the hip-girdle musculature (HP:0001445)2.42861552
27Abnormality of the musculature of the pelvis (HP:0001469)2.42861552
28Abnormality of the preputium (HP:0100587)2.41392374
29Drooling (HP:0002307)2.41330658
30Pancreatic fibrosis (HP:0100732)2.35480613
31Abnormality of the labia minora (HP:0012880)2.35163183
32Optic nerve hypoplasia (HP:0000609)2.27426152
33Hyperacusis (HP:0010780)2.25314954
34Midline defect of the nose (HP:0004122)2.25182242
35Heterotopia (HP:0002282)2.24787536
36Birth length less than 3rd percentile (HP:0003561)2.24499527
37Abnormality of the diencephalon (HP:0010662)2.23179107
38Chronic hepatic failure (HP:0100626)2.22583500
39Obsessive-compulsive behavior (HP:0000722)2.22579891
40Trigonocephaly (HP:0000243)2.22572960
41Nephronophthisis (HP:0000090)2.22174446
42True hermaphroditism (HP:0010459)2.19438268
43Cortical dysplasia (HP:0002539)2.19088698
44Excessive salivation (HP:0003781)2.15056192
45Genetic anticipation (HP:0003743)2.13534451
46Abnormality of the incisor (HP:0000676)2.11596451
47Clubbing of toes (HP:0100760)2.11568809
48Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.11495321
49Molar tooth sign on MRI (HP:0002419)2.10037910
50Abnormality of midbrain morphology (HP:0002418)2.10037910
51Ependymoma (HP:0002888)2.09962611
52Aqueductal stenosis (HP:0002410)2.08472380
53Duodenal stenosis (HP:0100867)2.07113616
54Small intestinal stenosis (HP:0012848)2.07113616
55Renal duplication (HP:0000075)2.06440881
56Abnormal lung lobation (HP:0002101)2.05786507
57Broad-based gait (HP:0002136)2.03339067
58Pendular nystagmus (HP:0012043)2.03224803
59Abnormality of the septum pellucidum (HP:0007375)2.02982743
60Rib fusion (HP:0000902)2.02971138
61Absent septum pellucidum (HP:0001331)2.02349284
62Proximal placement of thumb (HP:0009623)2.02039070
63Skull defect (HP:0001362)2.01439435
64Cupped ear (HP:0000378)2.00060203
65Facial hemangioma (HP:0000329)1.98776792
66Vaginal atresia (HP:0000148)1.97787054
67Myelodysplasia (HP:0002863)1.96960528
68Overriding aorta (HP:0002623)1.96771265
69Genital tract atresia (HP:0001827)1.96463695
70Gastrointestinal atresia (HP:0002589)1.95874197
71Deviation of the thumb (HP:0009603)1.95071926
72Thyroiditis (HP:0100646)1.94709170
73Abnormality of the renal medulla (HP:0100957)1.94127136
74Renovascular hypertension (HP:0100817)1.93813026
75Progressive cerebellar ataxia (HP:0002073)1.93656789
76Selective tooth agenesis (HP:0001592)1.93408808
77Preaxial hand polydactyly (HP:0001177)1.92928773
78Elfin facies (HP:0004428)1.92778122
79Colon cancer (HP:0003003)1.91639246
80Cutaneous finger syndactyly (HP:0010554)1.91132290
81Abnormal hair whorl (HP:0010721)1.90964553
82Prominent nose (HP:0000448)1.90458375
83Impulsivity (HP:0100710)1.90378180
84Abnormality of the nasal septum (HP:0000419)1.90304316
85Lissencephaly (HP:0001339)1.90156657
86Poor coordination (HP:0002370)1.89638081
87Anencephaly (HP:0002323)1.87831408
88Patellar aplasia (HP:0006443)1.86624944
89Absent radius (HP:0003974)1.86123868
90Hyperventilation (HP:0002883)1.86091057
91Abnormality of the duodenum (HP:0002246)1.85041711
92Bifid tongue (HP:0010297)1.84956708
93Maternal diabetes (HP:0009800)1.84411457
94Bony spicule pigmentary retinopathy (HP:0007737)1.83597925
95Neoplasm of striated muscle (HP:0009728)1.83110090
96Aplasia/Hypoplasia of the sternum (HP:0006714)1.82800137
97Lip pit (HP:0100267)1.82429025
98Absent forearm bone (HP:0003953)1.82122519
99Aplasia involving forearm bones (HP:0009822)1.82122519
100Truncal obesity (HP:0001956)1.81937932
101Esophageal atresia (HP:0002032)1.80393064
102Renal hypoplasia (HP:0000089)1.79190479
103Cutis marmorata (HP:0000965)1.78161458
104Dandy-Walker malformation (HP:0001305)1.77509166
105Skin tags (HP:0010609)1.76557497
106Astrocytoma (HP:0009592)1.76323608
107Abnormality of the astrocytes (HP:0100707)1.76323608
108Glioma (HP:0009733)1.75883996
109Embryonal renal neoplasm (HP:0011794)1.75480293
110Acute lymphatic leukemia (HP:0006721)1.75307382
111Optic nerve coloboma (HP:0000588)1.75108301
112Hypoplasia of the maxilla (HP:0000327)1.74819652
113Rhabdomyosarcoma (HP:0002859)1.74457974
114Sloping forehead (HP:0000340)1.74408641
115Spina bifida occulta (HP:0003298)1.73626244
116Oligodactyly (hands) (HP:0001180)1.73610422
117Aplasia/Hypoplasia of the patella (HP:0006498)1.72548163
118Medial flaring of the eyebrow (HP:0010747)1.71672501
119Absent eyebrow (HP:0002223)1.71598361
120Oligodactyly (HP:0012165)1.71500317
121Labial hypoplasia (HP:0000066)1.71329050
122Deep philtrum (HP:0002002)1.71179177
123Protruding tongue (HP:0010808)1.70666960
124Macroorchidism (HP:0000053)1.70381997
125Anophthalmia (HP:0000528)1.70291945
126Hemivertebrae (HP:0002937)1.69905767
127Abnormality of chromosome segregation (HP:0002916)1.69447642
128Nephroblastoma (Wilms tumor) (HP:0002667)1.69438073
129Agammaglobulinemia (HP:0004432)1.69213549
130Growth hormone deficiency (HP:0000824)1.69182817
131Reticulocytopenia (HP:0001896)1.68461931
132Cutaneous syndactyly (HP:0012725)1.67723847
133High anterior hairline (HP:0009890)1.67000559
134Depressed nasal tip (HP:0000437)1.66803868
135Partial agenesis of the corpus callosum (HP:0001338)1.66588247
1362-3 toe syndactyly (HP:0004691)1.66536029
137Gait imbalance (HP:0002141)1.66045435
138Urethral obstruction (HP:0000796)1.65482916
139Intestinal fistula (HP:0100819)1.64964905
140Preaxial foot polydactyly (HP:0001841)1.64305472
141Holoprosencephaly (HP:0001360)1.64172487
142Sclerocornea (HP:0000647)1.63191154
143Duplicated collecting system (HP:0000081)1.62703057
144Duplication of thumb phalanx (HP:0009942)1.62672008
145Attenuation of retinal blood vessels (HP:0007843)1.62345855
146Leukopenia (HP:0001882)1.62223718
147Triphalangeal thumb (HP:0001199)1.61798337
148Intestinal atresia (HP:0011100)1.61295592
149Abdominal situs inversus (HP:0003363)1.61205871
150Abnormality of abdominal situs (HP:0011620)1.61205871
151Flat cornea (HP:0007720)1.60661150
152Tracheoesophageal fistula (HP:0002575)1.60384510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.56542521
2BRD44.11907334
3CDC73.34201731
4TNIK3.19478335
5MKNK22.56401465
6SRPK12.34782568
7WNK32.34391373
8MKNK12.29639959
9MAP3K42.00656412
10BMPR1B2.00500748
11ATR1.98023618
12CAMK1D1.97889155
13TLK11.96965059
14MAP3K101.90921123
15YES11.89550550
16FRK1.89064660
17DYRK21.81824505
18CAMK1G1.81689035
19CDK91.78245423
20NEK21.76942458
21MAP4K11.76831344
22TAF11.58473385
23TTK1.56645335
24MARK11.54391175
25NUAK11.48581409
26CHEK21.46675067
27CDK41.45664071
28BUB11.45428255
29BRSK21.41494682
30STK38L1.37979727
31DYRK31.36749124
32CHEK11.36690423
33PNCK1.30610602
34ATM1.29297260
35LATS11.26803320
36STK101.23784591
37RPS6KB21.21731724
38MAP3K91.20675692
39* CDK71.20349761
40GRK11.20188833
41SIK21.18995023
42EEF2K1.17444368
43STK41.14482053
44FGFR21.12532429
45BCR1.11809599
46NTRK21.01611928
47CDK191.00954025
48PLK11.00683768
49TYRO31.00511383
50* CDK20.99168274
51TXK0.98911234
52TRIM280.98359927
53CASK0.97906298
54CSNK1D0.97506439
55AURKB0.96660045
56CDK60.95019673
57AKT30.94690121
58CDK30.92718851
59FGFR30.92371304
60STK160.91193480
61MTOR0.88085872
62CSNK1A1L0.87768396
63* CDK10.87669640
64BTK0.87069749
65MAP3K80.86946964
66STK110.85399332
67EPHA40.84398638
68PIM10.84326685
69MUSK0.83671631
70CSNK1G20.83668421
71STK30.81796522
72SGK2230.80982790
73SGK4940.80982790
74ALK0.80772424
75WEE10.80683703
76PRKD20.79064261
77RPS6KA40.78023138
78CSF1R0.77614187
79HIPK20.77135634
80SGK20.76838427
81OXSR10.76281040
82PLK40.73523112
83MAP2K70.72765128
84CSNK1G10.72733572
85CHUK0.72446765
86MAP4K20.72126896
87MAPK140.71386390
88MAPK150.68929888
89CLK10.66393205
90GSK3B0.66335831
91STK390.65632024
92WNK40.65382723
93PASK0.64691869
94* PRKDC0.64163159
95MELK0.63863079
96VRK10.63257677
97TSSK60.61558418
98HCK0.61126042
99PLK30.61037978
100PDGFRB0.60806566
101SGK30.60618566
102RPS6KA50.58161991
103FGFR10.57668986
104SGK10.55245691
105RPS6KB10.54616258
106ZAK0.54405975
107INSRR0.54314834
108CAMKK20.53739300
109NLK0.53687744
110MAPK130.53638039
111GRK60.53561457
112PRKCG0.52464419
113ICK0.52194742
114EIF2AK20.51917993
115NME10.51825841
116PLK20.50095396
117EPHA20.50041097
118MAPK100.49299214
119CSNK1E0.48449559
120CAMK40.48332886
121ACVR1B0.48194338
122UHMK10.47640165
123AKT10.47544644
124VRK20.47199303
125MAPK10.46771763
126CDC42BPA0.46573337
127PKN10.45090333
128ERBB20.44666928
129TGFBR10.43629000
130EPHA30.43367732
131CSNK1G30.43157574
132PRKAA10.42123994
133MARK20.41885705
134BRSK10.41842576
135MAPK80.41812698
136SIK30.41748668
137AKT20.40561218
138WNK10.39992151
139DYRK1A0.39616696

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034502.93390398
2Fanconi anemia pathway_Homo sapiens_hsa034602.85761968
3Mismatch repair_Homo sapiens_hsa034302.70950782
4Homologous recombination_Homo sapiens_hsa034402.56294627
5DNA replication_Homo sapiens_hsa030302.41225531
6Nicotine addiction_Homo sapiens_hsa050332.39120332
7Spliceosome_Homo sapiens_hsa030402.37457845
8mRNA surveillance pathway_Homo sapiens_hsa030152.29874613
9RNA transport_Homo sapiens_hsa030132.21365994
10Cell cycle_Homo sapiens_hsa041102.05224189
11Primary immunodeficiency_Homo sapiens_hsa053401.95664958
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.94463887
13Base excision repair_Homo sapiens_hsa034101.82853287
14RNA degradation_Homo sapiens_hsa030181.78909860
15Transcriptional misregulation in cancer_Homo sapiens_hsa052021.71534719
16Notch signaling pathway_Homo sapiens_hsa043301.71358696
17Basal cell carcinoma_Homo sapiens_hsa052171.68100882
18Phototransduction_Homo sapiens_hsa047441.66894688
19Systemic lupus erythematosus_Homo sapiens_hsa053221.66304276
20Selenocompound metabolism_Homo sapiens_hsa004501.62684022
21Lysine degradation_Homo sapiens_hsa003101.61522198
22MicroRNAs in cancer_Homo sapiens_hsa052061.55890345
23One carbon pool by folate_Homo sapiens_hsa006701.53376205
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.53239363
25Nucleotide excision repair_Homo sapiens_hsa034201.47787806
26Viral myocarditis_Homo sapiens_hsa054161.41030013
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37261603
28Taste transduction_Homo sapiens_hsa047421.36700319
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35472906
30Basal transcription factors_Homo sapiens_hsa030221.34032558
31B cell receptor signaling pathway_Homo sapiens_hsa046621.24157951
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.22302324
33Viral carcinogenesis_Homo sapiens_hsa052031.18091383
34Herpes simplex infection_Homo sapiens_hsa051681.18051952
35HTLV-I infection_Homo sapiens_hsa051661.11548367
36Hedgehog signaling pathway_Homo sapiens_hsa043401.10308950
37RNA polymerase_Homo sapiens_hsa030201.10178343
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08899104
39p53 signaling pathway_Homo sapiens_hsa041151.08697343
40Steroid biosynthesis_Homo sapiens_hsa001001.08375984
41Glutamatergic synapse_Homo sapiens_hsa047241.08280546
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08226632
43Propanoate metabolism_Homo sapiens_hsa006401.04553063
44Wnt signaling pathway_Homo sapiens_hsa043101.03326846
45Alcoholism_Homo sapiens_hsa050341.02342151
46Nitrogen metabolism_Homo sapiens_hsa009101.02165513
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01950217
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99299935
49Chronic myeloid leukemia_Homo sapiens_hsa052200.98167559
50Colorectal cancer_Homo sapiens_hsa052100.97985106
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97120357
52Olfactory transduction_Homo sapiens_hsa047400.96834716
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.96371691
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95663051
55T cell receptor signaling pathway_Homo sapiens_hsa046600.95182040
56Small cell lung cancer_Homo sapiens_hsa052220.94983634
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92786908
58mTOR signaling pathway_Homo sapiens_hsa041500.89616586
59Oocyte meiosis_Homo sapiens_hsa041140.89518426
60Dorso-ventral axis formation_Homo sapiens_hsa043200.88058148
61Morphine addiction_Homo sapiens_hsa050320.87646542
62Protein export_Homo sapiens_hsa030600.87206540
63Hematopoietic cell lineage_Homo sapiens_hsa046400.85930478
64Prostate cancer_Homo sapiens_hsa052150.84090972
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83710111
66Hippo signaling pathway_Homo sapiens_hsa043900.81521797
67Huntingtons disease_Homo sapiens_hsa050160.80104818
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79654462
69Pathways in cancer_Homo sapiens_hsa052000.78864512
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78637151
71Adherens junction_Homo sapiens_hsa045200.78563537
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.77953124
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77583181
74Epstein-Barr virus infection_Homo sapiens_hsa051690.77560363
75GABAergic synapse_Homo sapiens_hsa047270.77347918
76Antigen processing and presentation_Homo sapiens_hsa046120.77304431
77Linoleic acid metabolism_Homo sapiens_hsa005910.76121979
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75819549
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75166793
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74702669
81Long-term depression_Homo sapiens_hsa047300.73782771
82TGF-beta signaling pathway_Homo sapiens_hsa043500.73390086
83Inositol phosphate metabolism_Homo sapiens_hsa005620.72089307
84Ether lipid metabolism_Homo sapiens_hsa005650.71423253
85Circadian rhythm_Homo sapiens_hsa047100.71111537
86Serotonergic synapse_Homo sapiens_hsa047260.70813994
87Cocaine addiction_Homo sapiens_hsa050300.70535448
88Ribosome_Homo sapiens_hsa030100.69394305
89Measles_Homo sapiens_hsa051620.69344397
90Tight junction_Homo sapiens_hsa045300.68847589
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68035784
92Circadian entrainment_Homo sapiens_hsa047130.67463098
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66718816
94Axon guidance_Homo sapiens_hsa043600.66303110
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66272641
96Pyrimidine metabolism_Homo sapiens_hsa002400.65697387
97Acute myeloid leukemia_Homo sapiens_hsa052210.63373245
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.62889249
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.61984886
100ErbB signaling pathway_Homo sapiens_hsa040120.60270278
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59937493
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59746036
103Thyroid cancer_Homo sapiens_hsa052160.59106258
104Butanoate metabolism_Homo sapiens_hsa006500.58656104
105Hepatitis B_Homo sapiens_hsa051610.58269865
106MAPK signaling pathway_Homo sapiens_hsa040100.58100855
107Dopaminergic synapse_Homo sapiens_hsa047280.58044704
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56975769
109FoxO signaling pathway_Homo sapiens_hsa040680.55417426
110Non-small cell lung cancer_Homo sapiens_hsa052230.54366816
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.53110274
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52120122
113Type II diabetes mellitus_Homo sapiens_hsa049300.52115828
114Endometrial cancer_Homo sapiens_hsa052130.51689297
115Pancreatic cancer_Homo sapiens_hsa052120.50872392
116Cholinergic synapse_Homo sapiens_hsa047250.50722221
117Amphetamine addiction_Homo sapiens_hsa050310.50631877
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.49801812
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49461095
120Renal cell carcinoma_Homo sapiens_hsa052110.49264339
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47723127
122Proteoglycans in cancer_Homo sapiens_hsa052050.47671770
123Cardiac muscle contraction_Homo sapiens_hsa042600.46981240
124Melanoma_Homo sapiens_hsa052180.46811821
125Allograft rejection_Homo sapiens_hsa053300.46515011
126Insulin secretion_Homo sapiens_hsa049110.45112843
127Osteoclast differentiation_Homo sapiens_hsa043800.44195149
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43495056
129Chemokine signaling pathway_Homo sapiens_hsa040620.43458697
130Purine metabolism_Homo sapiens_hsa002300.43380030
131Choline metabolism in cancer_Homo sapiens_hsa052310.42872088
132cAMP signaling pathway_Homo sapiens_hsa040240.42789129
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42497500
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42217596
135Parkinsons disease_Homo sapiens_hsa050120.41015653
136Rap1 signaling pathway_Homo sapiens_hsa040150.40646276
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40143399
138Autoimmune thyroid disease_Homo sapiens_hsa053200.39183160
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39028695
140Influenza A_Homo sapiens_hsa051640.38767309
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38332208
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37702383
143Melanogenesis_Homo sapiens_hsa049160.36976230
144Fatty acid biosynthesis_Homo sapiens_hsa000610.36907639
145Oxidative phosphorylation_Homo sapiens_hsa001900.36054327
146Graft-versus-host disease_Homo sapiens_hsa053320.34664307
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34272541

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