POU2F2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.06371336
2regulation of B cell receptor signaling pathway (GO:0050855)5.00043930
3B cell receptor signaling pathway (GO:0050853)4.66347287
4regulation of protein heterodimerization activity (GO:0043497)4.01957548
5tolerance induction (GO:0002507)3.91620722
6negative regulation of cell killing (GO:0031342)3.83115376
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.83115376
8positive thymic T cell selection (GO:0045059)3.75254443
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.66238299
10regulation of histone H3-K27 methylation (GO:0061085)3.65553005
11viral transcription (GO:0019083)3.63826398
12regulation of B cell differentiation (GO:0045577)3.62729495
13positive regulation of B cell differentiation (GO:0045579)3.59652057
14CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.58968599
15cellular response to interleukin-15 (GO:0071350)3.58958262
16ribosomal small subunit biogenesis (GO:0042274)3.57741506
17activated T cell proliferation (GO:0050798)3.51990999
18response to peptidoglycan (GO:0032494)3.46336265
19* mature B cell differentiation (GO:0002335)3.45067284
20antigen processing and presentation of endogenous antigen (GO:0019883)3.44852490
21regulation of interferon-beta biosynthetic process (GO:0045357)3.42762279
22regulation of regulatory T cell differentiation (GO:0045589)3.41118971
23regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.38725271
24negative regulation of lymphocyte mediated immunity (GO:0002707)3.38177177
25detection of bacterium (GO:0016045)3.37475036
26antigen receptor-mediated signaling pathway (GO:0050851)3.35467070
27detection of other organism (GO:0098543)3.33651210
28T cell migration (GO:0072678)3.32660981
29response to interleukin-15 (GO:0070672)3.32622893
30translational termination (GO:0006415)3.32015647
31regulation of antigen processing and presentation (GO:0002577)3.30353281
32germinal center formation (GO:0002467)3.30324181
33mature B cell differentiation involved in immune response (GO:0002313)3.27379390
34B cell homeostasis (GO:0001782)3.26599939
35hepatocyte apoptotic process (GO:0097284)3.26068977
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.23397247
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.23397247
38positive regulation by organism of defense response of other organism involved in symbiotic interact3.23397247
39modulation by symbiont of host immune response (GO:0052553)3.23397247
40positive regulation by symbiont of host defense response (GO:0052509)3.23397247
41modulation by symbiont of host defense response (GO:0052031)3.23397247
42regulation of gamma-delta T cell differentiation (GO:0045586)3.22330192
43T cell homeostasis (GO:0043029)3.19317026
44regulation of gamma-delta T cell activation (GO:0046643)3.18880739
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.18644005
46defense response to protozoan (GO:0042832)3.17569770
47regulation of B cell proliferation (GO:0030888)3.17326770
48NIK/NF-kappaB signaling (GO:0038061)3.17289684
49positive T cell selection (GO:0043368)3.16781371
50positive regulation of B cell proliferation (GO:0030890)3.14038061
51interferon-gamma production (GO:0032609)3.13312266
52negative thymic T cell selection (GO:0045060)3.12645934
53positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.12579771
54thymic T cell selection (GO:0045061)3.10862227
55leukocyte aggregation (GO:0070486)3.09886899
56negative T cell selection (GO:0043383)3.06747583
57mast cell activation (GO:0045576)3.05831715
58negative regulation of T-helper cell differentiation (GO:0045623)3.05322588
59negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.05322588
60positive regulation of mast cell activation (GO:0033005)3.03327271
61T cell selection (GO:0045058)3.02706889
62positive regulation of NF-kappaB import into nucleus (GO:0042346)3.02219295
63regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.01382470
64respiratory burst (GO:0045730)3.00248384
65cellular response to type I interferon (GO:0071357)2.99649803
66type I interferon signaling pathway (GO:0060337)2.99649803
67positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.99499433
68negative regulation of leukocyte mediated immunity (GO:0002704)2.98775556
69response to type I interferon (GO:0034340)2.98565751
70response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.97611747
71response to host immune response (GO:0052572)2.97611747
72negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95178295
73lymphocyte homeostasis (GO:0002260)2.94850322
74regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.94384296
75regulation of natural killer cell mediated immunity (GO:0002715)2.94384296
76lymphoid progenitor cell differentiation (GO:0002320)2.93290247
77neural tube formation (GO:0001841)2.93285950
78antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.93185919
79antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.93185919
80positive regulation of T cell apoptotic process (GO:0070234)2.93099610
81cellular response to nerve growth factor stimulus (GO:1990090)2.92439952
82response to nerve growth factor (GO:1990089)2.92439952
83regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.88181297
84histone H3-K4 trimethylation (GO:0080182)2.87040189
85regulation of alpha-beta T cell proliferation (GO:0046640)2.86855520
86microglial cell activation (GO:0001774)2.86391204
87regulation of interleukin-2 biosynthetic process (GO:0045076)2.85924015
88B cell mediated immunity (GO:0019724)2.85889576
89lymph node development (GO:0048535)2.85813086
90pyrimidine nucleobase catabolic process (GO:0006208)2.85735229
91response to protozoan (GO:0001562)2.85017881
92regulation of mast cell activation (GO:0033003)2.84219151
93positive regulation of B cell activation (GO:0050871)2.82271171
94B cell proliferation (GO:0042100)2.82074782
95negative regulation of alpha-beta T cell activation (GO:0046636)2.81802012
96negative regulation of calcium ion transport into cytosol (GO:0010523)2.81235419
97cellular extravasation (GO:0045123)2.80645741
98positive regulation of antigen processing and presentation (GO:0002579)2.80292299
99macrophage activation involved in immune response (GO:0002281)2.80100648
100myeloid cell activation involved in immune response (GO:0002275)2.78620838
101regulation of isotype switching to IgG isotypes (GO:0048302)2.78614403
102snRNA transcription (GO:0009301)2.78176381
103presynaptic membrane assembly (GO:0097105)2.76815182
104positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.76232300
105negative regulation of interleukin-12 production (GO:0032695)2.75256473
106myeloid dendritic cell activation (GO:0001773)2.74878123
107antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.73883085
108regulation of dendritic cell antigen processing and presentation (GO:0002604)2.73461595
109regulation of interleukin-12 biosynthetic process (GO:0045075)2.73378655
110T cell receptor signaling pathway (GO:0050852)2.73268056
111regulation of interferon-gamma biosynthetic process (GO:0045072)2.71987647
112myeloid dendritic cell differentiation (GO:0043011)2.70360676
113regulation of T cell tolerance induction (GO:0002664)2.69798932
114immunoglobulin mediated immune response (GO:0016064)2.69698649
115positive regulation of interferon-alpha production (GO:0032727)2.69672309
116positive regulation of granulocyte differentiation (GO:0030854)2.68514836
117regulation of T-helper 1 cell differentiation (GO:0045625)2.68061476
118neutrophil activation (GO:0042119)2.68012609
119regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.67857572
120negative regulation of B cell proliferation (GO:0030889)2.67805127
121detection of external biotic stimulus (GO:0098581)2.67269154
122regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.66829325
123negative regulation of T cell mediated immunity (GO:0002710)2.66438780
124regulation of B cell activation (GO:0050864)2.63947603
125regulation of interferon-alpha production (GO:0032647)2.63815521
126negative regulation of bone resorption (GO:0045779)2.63742408
127negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.61455171
128neutrophil activation involved in immune response (GO:0002283)2.60264458
129* B cell activation (GO:0042113)2.60211499
130T cell costimulation (GO:0031295)2.58458606
131modulation by virus of host process (GO:0019054)2.58419501
132interferon-gamma-mediated signaling pathway (GO:0060333)2.58373933
133T cell proliferation (GO:0042098)2.57583344
134immune response-activating cell surface receptor signaling pathway (GO:0002429)2.57504266
135SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.57150126
136cotranslational protein targeting to membrane (GO:0006613)2.56383401
137leukocyte homeostasis (GO:0001776)2.55905911

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.17282565
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.24396015
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.94128707
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.86744829
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.50902460
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.48945916
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.39822443
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.37173784
9EZH2_22144423_ChIP-Seq_EOC_Human3.06667833
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.88947655
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.86945953
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.80223320
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.78166484
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.68943036
15RUNX_20019798_ChIP-Seq_JUKART_Human2.59358450
16SCL_19346495_ChIP-Seq_HPC-7_Human2.57510520
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.57037152
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.46975468
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39755740
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.33834670
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.19670470
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02717975
23MYB_26560356_Chip-Seq_TH2_Human1.98309733
24TAF15_26573619_Chip-Seq_HEK293_Human1.91655745
25MYB_26560356_Chip-Seq_TH1_Human1.85623259
26VDR_21846776_ChIP-Seq_THP-1_Human1.85087628
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.83723390
28DROSHA_22980978_ChIP-Seq_HELA_Human1.82995181
29* REST_21632747_ChIP-Seq_MESCs_Mouse1.81847397
30KDM2B_26808549_Chip-Seq_DND41_Human1.81671229
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80566322
32* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75552166
33SPI1_23547873_ChIP-Seq_NB4_Human1.75544626
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.75053478
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74576944
36VDR_24763502_ChIP-Seq_THP-1_Human1.71586818
37* MAF_26560356_Chip-Seq_TH1_Human1.71282337
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70298084
39* MYC_22102868_ChIP-Seq_BL_Human1.68093444
40UTX_26944678_Chip-Seq_JUKART_Human1.54481023
41GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51955704
42IGF1R_20145208_ChIP-Seq_DFB_Human1.49466793
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.48654388
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47185685
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46296138
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40206861
47* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39396599
48* REST_18959480_ChIP-ChIP_MESCs_Mouse1.37917400
49LXR_22292898_ChIP-Seq_THP-1_Human1.37115555
50KDM2B_26808549_Chip-Seq_JURKAT_Human1.37026732
51* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36534442
52BCL6_27268052_Chip-Seq_Bcells_Human1.34383669
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.33823117
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33476480
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.32936198
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32690712
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32653862
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32534765
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32482226
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30449301
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30145335
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29671744
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28889344
64VDR_24787735_ChIP-Seq_THP-1_Human1.28062558
65MAF_26560356_Chip-Seq_TH2_Human1.26127212
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23797570
67PU_27001747_Chip-Seq_BMDM_Mouse1.23786969
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23431649
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.23425248
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.23167013
71BCOR_27268052_Chip-Seq_Bcells_Human1.18676774
72SPI1_23127762_ChIP-Seq_K562_Human1.18143494
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17882295
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17853418
75GBX2_23144817_ChIP-Seq_PC3_Human1.17486125
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16959840
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15765434
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.14966504
79EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14775785
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14326956
81MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13734248
82IRF1_19129219_ChIP-ChIP_H3396_Human1.12128289
83KDM2B_26808549_Chip-Seq_K562_Human1.11119055
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10412351
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09954239
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.08969974
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06793656
88P68_20966046_ChIP-Seq_HELA_Human1.06548571
89CIITA_25753668_ChIP-Seq_RAJI_Human1.05247893
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05230727
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04951550
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02729243
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02162788
94OCT4_19829295_ChIP-Seq_ESCs_Human1.01970960
95GATA3_27048872_Chip-Seq_THYMUS_Human1.01916463
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01580134
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01311026
98* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00714509
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.00426040
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.00380680
101RNF2_27304074_Chip-Seq_NSC_Mouse1.00001773
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99329037
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98583512
104RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98572817
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98431470
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97732366
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96471735
108RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96064578
109TCF7_22412390_ChIP-Seq_EML_Mouse0.95804896
110CMYC_18555785_Chip-Seq_ESCs_Mouse0.95781160
111POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94969611
112STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94368110
113CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94100328
114P53_22387025_ChIP-Seq_ESCs_Mouse0.94061410
115SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93943226
116RNF2_27304074_Chip-Seq_ESCs_Mouse0.93888378
117E2F1_20622854_ChIP-Seq_HELA_Human0.93592064
118AR_21572438_ChIP-Seq_LNCaP_Human0.93161978
119JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92519219
120VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92467671
121P300_18555785_Chip-Seq_ESCs_Mouse0.92375731
122E2F1_18555785_Chip-Seq_ESCs_Mouse0.92199823
123STAT3_18555785_Chip-Seq_ESCs_Mouse0.92069533
124E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91241507
125* P300_27268052_Chip-Seq_Bcells_Human0.89358687
126SMRT_27268052_Chip-Seq_Bcells_Human0.89120362
127ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88923906
128CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88432788
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88347380
130SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88322250
131ELK4_26923725_Chip-Seq_MESODERM_Mouse0.88127902
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87743160
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87680397
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.87632634
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87092544
136OCT4_18555785_Chip-Seq_ESCs_Mouse0.86781728
137* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86588730
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86396429
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86077101
140ESRRB_18555785_Chip-Seq_ESCs_Mouse0.84511178
141* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83147095
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82282594
143ZFX_18555785_Chip-Seq_ESCs_Mouse0.82183952
144ELF1_17652178_ChIP-ChIP_JURKAT_Human0.80606665
145BRD4_27068464_Chip-Seq_AML-cells_Mouse0.80594984
146PU1_27457419_Chip-Seq_LIVER_Mouse0.80480481
147OCT4_21477851_ChIP-Seq_ESCs_Mouse0.80375185
148PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80010167
149CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79324948
150Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78934560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.98001250
2MP0001790_abnormal_immune_system3.59844814
3MP0005387_immune_system_phenotype3.59844814
4* MP0001800_abnormal_humoral_immune3.56984134
5MP0005671_abnormal_response_to3.32667713
6MP0003303_peritoneal_inflammation3.16158160
7MP0005000_abnormal_immune_tolerance2.91326166
8* MP0002452_abnormal_antigen_presenting2.86490187
9* MP0002723_abnormal_immune_serum2.72672846
10MP0000685_abnormal_immune_system2.67131647
11MP0003763_abnormal_thymus_physiology2.58829803
12* MP0002420_abnormal_adaptive_immunity2.55682899
13* MP0001819_abnormal_immune_cell2.51432211
14MP0005174_abnormal_tail_pigmentation2.37163241
15MP0003136_yellow_coat_color2.32749482
16MP0005409_darkened_coat_color2.31926125
17MP0005025_abnormal_response_to2.22476382
18* MP0002398_abnormal_bone_marrow2.21659475
19MP0006292_abnormal_olfactory_placode2.20975568
20MP0002148_abnormal_hypersensitivity_rea2.18939210
21* MP0000716_abnormal_immune_system2.09499256
22MP0004381_abnormal_hair_follicle2.08541606
23MP0003880_abnormal_central_pattern2.03670836
24MP0002419_abnormal_innate_immunity2.02233336
25MP0000015_abnormal_ear_pigmentation2.01899840
26MP0009785_altered_susceptibility_to2.01331233
27MP0002138_abnormal_hepatobiliary_system2.01019433
28MP0002396_abnormal_hematopoietic_system1.98445065
29MP0003436_decreased_susceptibility_to1.96946076
30MP0009379_abnormal_foot_pigmentation1.95229044
31MP0004510_myositis1.88862065
32MP0009764_decreased_sensitivity_to1.87819081
33MP0000689_abnormal_spleen_morphology1.86511502
34MP0002405_respiratory_system_inflammati1.79665273
35MP0001873_stomach_inflammation1.79589897
36MP0003724_increased_susceptibility_to1.78278821
37MP0009333_abnormal_splenocyte_physiolog1.76758191
38MP0000465_gastrointestinal_hemorrhage1.76626743
39MP0002653_abnormal_ependyma_morphology1.70102577
40MP0002722_abnormal_immune_system1.66115517
41MP0006082_CNS_inflammation1.63688140
42* MP0002429_abnormal_blood_cell1.62216607
43MP0002277_abnormal_respiratory_mucosa1.60344882
44MP0003866_abnormal_defecation1.51215339
45MP0001188_hyperpigmentation1.48700406
46MP0002166_altered_tumor_susceptibility1.44548519
47MP0000703_abnormal_thymus_morphology1.44203513
48MP0005464_abnormal_platelet_physiology1.43812149
49MP0005310_abnormal_salivary_gland1.34867256
50MP0001845_abnormal_inflammatory_respons1.34785763
51MP0004130_abnormal_muscle_cell1.33039085
52MP0002102_abnormal_ear_morphology1.31914121
53MP0001986_abnormal_taste_sensitivity1.31696515
54MP0001853_heart_inflammation1.31394836
55MP0001348_abnormal_lacrimal_gland1.28237159
56MP0001851_eye_inflammation1.27180556
57MP0010155_abnormal_intestine_physiology1.24542032
58MP0002933_joint_inflammation1.23242010
59MP0002095_abnormal_skin_pigmentation1.19654588
60MP0005075_abnormal_melanosome_morpholog1.17146235
61MP0002006_tumorigenesis1.14767194
62MP0004742_abnormal_vestibular_system1.13254988
63MP0003172_abnormal_lysosome_physiology1.12828288
64MP0008260_abnormal_autophagy1.12395510
65MP0003635_abnormal_synaptic_transmissio1.12054066
66MP0005451_abnormal_body_composition1.08115608
67MP0009278_abnormal_bone_marrow1.06848973
68MP0002009_preneoplasia1.06740307
69MP0002733_abnormal_thermal_nociception1.06089819
70MP0008877_abnormal_DNA_methylation1.03938385
71MP0003787_abnormal_imprinting0.98812171
72MP0008874_decreased_physiological_sensi0.97961673
73MP0004808_abnormal_hematopoietic_stem0.96678206
74MP0005257_abnormal_intraocular_pressure0.95682617
75MP0003879_abnormal_hair_cell0.95317263
76MP0003300_gastrointestinal_ulcer0.93756192
77MP0002063_abnormal_learning/memory/cond0.92993855
78MP0002693_abnormal_pancreas_physiology0.89665791
79MP0000604_amyloidosis0.89526283
80MP0000490_abnormal_crypts_of0.89180619
81MP0001663_abnormal_digestive_system0.88532062
82MP0001970_abnormal_pain_threshold0.87476268
83MP0008057_abnormal_DNA_replication0.87441757
84MP0003938_abnormal_ear_development0.86341713
85MP0000778_abnormal_nervous_system0.85455233
86MP0003121_genomic_imprinting0.84490877
87MP0003646_muscle_fatigue0.84318174
88MP0008469_abnormal_protein_level0.82516757
89MP0002572_abnormal_emotion/affect_behav0.79936772
90MP0000566_synostosis0.79878916
91MP0008995_early_reproductive_senescence0.78921096
92MP0002638_abnormal_pupillary_reflex0.78808367
93MP0001533_abnormal_skeleton_physiology0.78575792
94MP0005083_abnormal_biliary_tract0.75561330
95MP0002064_seizures0.74243623
96MP0004947_skin_inflammation0.73977473
97MP0004859_abnormal_synaptic_plasticity0.72164085
98MP0003122_maternal_imprinting0.71443022
99MP0002163_abnormal_gland_morphology0.70587373
100MP0004142_abnormal_muscle_tone0.68882971
101MP0002132_abnormal_respiratory_system0.68724992
102MP0005397_hematopoietic_system_phenotyp0.68224570
103MP0001545_abnormal_hematopoietic_system0.68224570
104MP0000470_abnormal_stomach_morphology0.67909482
105MP0009745_abnormal_behavioral_response0.67742262
106MP0002998_abnormal_bone_remodeling0.67463914
107MP0003183_abnormal_peptide_metabolism0.66919557
108MP0001968_abnormal_touch/_nociception0.66580473
109MP0006276_abnormal_autonomic_nervous0.65551045
110MP0005423_abnormal_somatic_nervous0.65514965
111MP0001486_abnormal_startle_reflex0.64093943
112MP0003448_altered_tumor_morphology0.63114089
113MP0005645_abnormal_hypothalamus_physiol0.62978300
114MP0001440_abnormal_grooming_behavior0.62867229
115MP0001905_abnormal_dopamine_level0.62101883
116MP0000569_abnormal_digit_pigmentation0.61665142
117MP0005381_digestive/alimentary_phenotyp0.61520586
118MP0002177_abnormal_outer_ear0.61135551
119MP0005084_abnormal_gallbladder_morpholo0.60616254
120MP0005390_skeleton_phenotype0.59886287
121MP0008058_abnormal_DNA_repair0.59621194
122MP0003638_abnormal_response/metabolism_0.58886361
123MP0003011_delayed_dark_adaptation0.57787961
124MP0005448_abnormal_energy_balance0.57432708
125MP0003123_paternal_imprinting0.56818929
126MP0002272_abnormal_nervous_system0.56605209
127MP0009765_abnormal_xenobiotic_induced0.56517009
128MP0000343_altered_response_to0.56412561
129MP0005535_abnormal_body_temperature0.55892600
130MP0003828_pulmonary_edema0.54808633
131MP0000858_altered_metastatic_potential0.54493027
132MP0003045_fibrosis0.53354348
133MP0008569_lethality_at_weaning0.53119521
134MP0000920_abnormal_myelination0.52334302
135MP0005379_endocrine/exocrine_gland_phen0.51525109
136MP0002067_abnormal_sensory_capabilities0.50994575
137MP0001963_abnormal_hearing_physiology0.49348852
138MP0002928_abnormal_bile_duct0.48860381
139MP0002557_abnormal_social/conspecific_i0.48608764
140MP0002019_abnormal_tumor_incidence0.46892092

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)5.93236079
2Recurrent sinusitis (HP:0011108)4.27676490
3Meningitis (HP:0001287)4.05822515
4Recurrent abscess formation (HP:0002722)4.00789697
5Recurrent bronchitis (HP:0002837)3.94841242
6IgM deficiency (HP:0002850)3.88867343
7Gastrointestinal stroma tumor (HP:0100723)3.88840146
8Inflammation of the large intestine (HP:0002037)3.77144030
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.73689919
10Obstructive lung disease (HP:0006536)3.72429676
11Chronic obstructive pulmonary disease (HP:0006510)3.72429676
12Panhypogammaglobulinemia (HP:0003139)3.62906824
13Recurrent cutaneous fungal infections (HP:0011370)3.61863436
14Chronic mucocutaneous candidiasis (HP:0002728)3.61863436
15Colitis (HP:0002583)3.57193577
16Recurrent bacterial skin infections (HP:0005406)3.53728611
17Cellulitis (HP:0100658)3.52434223
18Orchitis (HP:0100796)3.48999472
19Stomatitis (HP:0010280)3.44689774
20Agitation (HP:0000713)3.44345658
21Gastrointestinal inflammation (HP:0004386)3.42487187
22Eczematoid dermatitis (HP:0000976)3.38227080
23Mediastinal lymphadenopathy (HP:0100721)3.35645581
24Recurrent viral infections (HP:0004429)3.33552776
25Recurrent fungal infections (HP:0002841)3.29787295
26Vasculitis (HP:0002633)3.18318251
27Hypochromic anemia (HP:0001931)3.16844003
28Recurrent pneumonia (HP:0006532)3.07424426
29Lymphopenia (HP:0001888)3.05769569
30Recurrent skin infections (HP:0001581)3.05276491
31Chronic otitis media (HP:0000389)3.03666256
32Gastrointestinal infarctions (HP:0005244)3.01150298
33Abnormality of B cell number (HP:0010975)2.91126894
34B lymphocytopenia (HP:0010976)2.91126894
35Chronic sinusitis (HP:0011109)2.89988877
36Reticulocytopenia (HP:0001896)2.89055152
37Abnormality of cells of the lymphoid lineage (HP:0012140)2.87699090
38Recurrent lower respiratory tract infections (HP:0002783)2.78193068
39Chronic diarrhea (HP:0002028)2.62190699
40Elevated erythrocyte sedimentation rate (HP:0003565)2.61829337
41Papilloma (HP:0012740)2.60198722
42Verrucae (HP:0200043)2.60198722
43IgG deficiency (HP:0004315)2.58879777
44Abnormality of the fingertips (HP:0001211)2.52860237
45Abnormal rod and cone electroretinograms (HP:0008323)2.52577140
46Thyroiditis (HP:0100646)2.51119359
47Impulsivity (HP:0100710)2.49234165
48Keratoconjunctivitis sicca (HP:0001097)2.45235823
49Urticaria (HP:0001025)2.44837844
50Obstructive sleep apnea (HP:0002870)2.43197957
51Osteomyelitis (HP:0002754)2.39330894
52Emphysema (HP:0002097)2.34701445
53Myositis (HP:0100614)2.34168901
54Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.33966041
55Abnormality of T cells (HP:0002843)2.32963616
56Increased IgM level (HP:0003496)2.32760007
57T lymphocytopenia (HP:0005403)2.32389960
58Abnormality of incisor morphology (HP:0011063)2.30512238
59Nasal polyposis (HP:0100582)2.30219502
60Bronchitis (HP:0012387)2.29304969
61Abnormality of cells of the erythroid lineage (HP:0012130)2.28270327
62Keratoconjunctivitis (HP:0001096)2.27682986
63Abnormality of T cell number (HP:0011839)2.24998155
64Recurrent otitis media (HP:0000403)2.22467402
65Pallor (HP:0000980)2.22118370
66Hypochromic microcytic anemia (HP:0004840)2.21969013
67IgA deficiency (HP:0002720)2.21531761
68Encephalitis (HP:0002383)2.20683070
69Sepsis (HP:0100806)2.17863675
70Spontaneous hematomas (HP:0007420)2.16697795
71Gingivitis (HP:0000230)2.16302945
72Abnormality of T cell physiology (HP:0011840)2.15115847
73Prolonged bleeding time (HP:0003010)2.14530035
74Glomerulonephritis (HP:0000099)2.13264703
75Retrobulbar optic neuritis (HP:0100654)2.11246510
76Optic neuritis (HP:0100653)2.11246510
77Flared iliac wings (HP:0002869)2.11011913
78Papilledema (HP:0001085)2.09741570
79Progressive cerebellar ataxia (HP:0002073)2.08947301
80Pulmonary infiltrates (HP:0002113)2.08781527
81Chest pain (HP:0100749)2.08534081
82Abnormal number of erythroid precursors (HP:0012131)2.08378869
83Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07677311
84Abnormality of glycolipid metabolism (HP:0010969)2.07262872
85Abnormality of liposaccharide metabolism (HP:0010968)2.07262872
86Abnormality of glycosphingolipid metabolism (HP:0004343)2.07262872
87Mutism (HP:0002300)2.05422628
88Increased IgE level (HP:0003212)2.04875110
89Lymphoma (HP:0002665)2.03703848
90Parakeratosis (HP:0001036)2.01765065
91Leukopenia (HP:0001882)2.01144593
92Restrictive lung disease (HP:0002091)2.00020420
93Abnormality of binocular vision (HP:0011514)1.99729860
94Diplopia (HP:0000651)1.99729860
95Abnormality of the axillary hair (HP:0100134)1.99293040
96Abnormality of secondary sexual hair (HP:0009888)1.99293040
97Abnormality of eosinophils (HP:0001879)1.99269560
98Severe combined immunodeficiency (HP:0004430)1.99123183
99Microcytic anemia (HP:0001935)1.98965536
100Abnormality of the prostate (HP:0008775)1.98805827
101Abnormality of macrophages (HP:0004311)1.98184173
102Bronchiectasis (HP:0002110)1.97630688
103Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96023054
104Pulmonary embolism (HP:0002204)1.95708754
105Clubbing of toes (HP:0100760)1.95071288
106Macrocytic anemia (HP:0001972)1.94581037
107Eosinophilia (HP:0001880)1.94089540
108Chromosomal breakage induced by crosslinking agents (HP:0003221)1.93204778
109Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.92789103
110Autoimmune hemolytic anemia (HP:0001890)1.86902266
111Purpura (HP:0000979)1.86179370
112Leukocytosis (HP:0001974)1.86145204
113Chromsome breakage (HP:0040012)1.84650785
114Peripheral hypomyelination (HP:0007182)1.84465926
115Prostate neoplasm (HP:0100787)1.84080112
116Nonprogressive disorder (HP:0003680)1.83617264
117Polyphagia (HP:0002591)1.83544320
118Disinhibition (HP:0000734)1.82733491
119Abnormality of the nasal mucosa (HP:0000433)1.82346205
120Limb dystonia (HP:0002451)1.81931920
121Abnormality of the pleura (HP:0002103)1.81892680
122Pustule (HP:0200039)1.80467226
123Genetic anticipation (HP:0003743)1.77972348
124Epistaxis (HP:0000421)1.77466239
125Abnormality of DNA repair (HP:0003254)1.77221015
126Thrombocytosis (HP:0001894)1.76564421
127Recurrent gram-negative bacterial infections (HP:0005420)1.75563623
128Abnormality of the endocardium (HP:0004306)1.75516419
129Thoracic kyphosis (HP:0002942)1.74662340
130Hypergammaglobulinemia (HP:0010702)1.73115623
131Abnormal hair whorl (HP:0010721)1.72288295
132Hemoptysis (HP:0002105)1.68285375
133Small epiphyses (HP:0010585)1.67605433
134Progressive inability to walk (HP:0002505)1.67494706
135Cheilitis (HP:0100825)1.67399637
136Absent/shortened dynein arms (HP:0200106)1.66569793
137Dynein arm defect of respiratory motile cilia (HP:0012255)1.66569793
138Granulocytopenia (HP:0001913)1.66118124
139Abnormality of the intervertebral disk (HP:0005108)1.61832711

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.87185647
2BLK3.34599897
3CASK3.20674142
4ERN12.64249374
5TXK2.63917024
6IRAK42.44226349
7MAP3K142.29864718
8SIK22.23318185
9CLK12.17686027
10FES2.16628252
11IRAK32.11140250
12PRKD22.05409716
13RIPK41.98171059
14PRPF4B1.92686947
15MAP3K131.90806500
16CSF1R1.86991337
17MKNK21.86502478
18SYK1.84496740
19MARK11.79730616
20TNIK1.72864968
21BTK1.69345665
22KIT1.67245494
23MAP3K111.65605683
24TGFBR21.64108671
25TLK11.63962336
26IKBKE1.62118299
27MUSK1.57214762
28TEC1.54424750
29TYK21.53091566
30GRK71.52366885
31GRK61.49686234
32SRPK11.49599265
33TYRO31.47259188
34IKBKB1.41552578
35FGR1.40358383
36JAK31.39764653
37MAP2K31.38993331
38HCK1.37413871
39LYN1.36241410
40DYRK21.34869701
41ZAP701.34275367
42SIK31.33605604
43NLK1.32413128
44LCK1.30881662
45CSK1.27842962
46TAOK11.25420112
47TNK21.25055431
48MAP3K41.20412279
49TBK11.19618745
50STK101.16756944
51ITK1.15095687
52JAK11.07971852
53CAMKK11.05533517
54TAOK21.05192776
55MKNK11.04510926
56HIPK21.01547901
57NME20.94750472
58YES10.94747998
59TAOK30.93335498
60MST40.91297316
61PKN10.90017873
62PRKCQ0.89571795
63GRK10.86359005
64ADRBK20.84343421
65MAPK150.83822402
66SGK2230.83419234
67SGK4940.83419234
68CDC42BPA0.82856279
69STK110.82707996
70RPS6KA20.81884293
71MARK30.81532329
72IRAK10.80677866
73PIM10.79334741
74STK380.78771500
75DYRK30.78576646
76SGK20.77298605
77SIK10.76853782
78PRKCZ0.75853866
79CAMKK20.75135776
80IRAK20.74482316
81PRKCH0.73456355
82CAMK1G0.71284314
83CHUK0.70667647
84CAMK40.70359453
85EIF2AK20.67564369
86MAP3K30.66321748
87STK30.64972281
88CDK30.63007665
89EPHB10.62535508
90SGK10.62479887
91MAP2K40.62127572
92DYRK1B0.61530603
93CSNK1G10.60745186
94BMPR20.60277744
95SGK30.60221527
96MARK20.59326012
97DAPK20.57067103
98PAK30.56230851
99MAPK130.55647215
100CDK90.53905430
101PDK10.52829250
102BMPR1B0.51185142
103MAP2K70.51087423
104MAP3K100.50359943
105RPS6KA50.49978052
106VRK10.49351173
107CDK80.48980935
108MAPK40.48917264
109ABL10.47761991
110CDK120.47452366
111BRD40.46906039
112RPS6KA60.45714110
113MAPK120.45633826
114MAPK70.44912776
115CDK50.43876246
116UHMK10.43119781
117CDK190.42528184
118MAP2K60.41071324
119PRKD10.39309983
120RPS6KC10.39128340
121RPS6KL10.39128340
122MAP3K70.37975863
123CSNK1A1L0.37927764
124PASK0.36266116
125PRKCD0.35318191
126LRRK20.34432592
127CDK40.34387960
128MAP3K10.32036021
129FYN0.31577147
130NUAK10.31436700
131CAMK10.31104918
132CSNK1G30.30792763
133STK160.27025351
134CAMK1D0.26841606
135WNK10.26475068
136MAPKAPK20.26052814
137JAK20.25063926
138DYRK1A0.24523740
139PIM20.24062138
140NTRK20.23991503
141PNCK0.23987962
142MATK0.23911393

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.69121721
2B cell receptor signaling pathway_Homo sapiens_hsa046623.03100156
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.34740654
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.32255876
5Ribosome_Homo sapiens_hsa030102.29093036
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.17444859
7Hematopoietic cell lineage_Homo sapiens_hsa046402.16765282
8T cell receptor signaling pathway_Homo sapiens_hsa046601.95697274
9Osteoclast differentiation_Homo sapiens_hsa043801.92566084
10Measles_Homo sapiens_hsa051621.91350665
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.90369662
12Leishmaniasis_Homo sapiens_hsa051401.76203428
13Allograft rejection_Homo sapiens_hsa053301.74491698
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63585504
15Graft-versus-host disease_Homo sapiens_hsa053321.62383118
16Asthma_Homo sapiens_hsa053101.59589073
17Autoimmune thyroid disease_Homo sapiens_hsa053201.49062830
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46405570
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43110980
20Antigen processing and presentation_Homo sapiens_hsa046121.42976649
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42913802
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.38687296
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37172787
24Chemokine signaling pathway_Homo sapiens_hsa040621.35259296
25Herpes simplex infection_Homo sapiens_hsa051681.34353556
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29019709
27Other glycan degradation_Homo sapiens_hsa005111.23160336
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21695461
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19012869
30Acute myeloid leukemia_Homo sapiens_hsa052211.13356938
31Malaria_Homo sapiens_hsa051441.11492779
32Fanconi anemia pathway_Homo sapiens_hsa034601.10860620
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10125600
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09086036
35Phagosome_Homo sapiens_hsa041451.08307233
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07940984
37Staphylococcus aureus infection_Homo sapiens_hsa051501.06373841
38Tuberculosis_Homo sapiens_hsa051521.05062350
39Non-homologous end-joining_Homo sapiens_hsa034501.01575827
40Influenza A_Homo sapiens_hsa051640.98938181
41Homologous recombination_Homo sapiens_hsa034400.95030596
42Hepatitis B_Homo sapiens_hsa051610.94919601
43Basal transcription factors_Homo sapiens_hsa030220.93054309
44African trypanosomiasis_Homo sapiens_hsa051430.93030498
45Pertussis_Homo sapiens_hsa051330.92781449
46Spliceosome_Homo sapiens_hsa030400.91722362
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90741054
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89446011
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89239694
50Toxoplasmosis_Homo sapiens_hsa051450.88730113
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88444362
52Platelet activation_Homo sapiens_hsa046110.80156777
53Cholinergic synapse_Homo sapiens_hsa047250.78839379
54Epstein-Barr virus infection_Homo sapiens_hsa051690.78759018
55Sphingolipid metabolism_Homo sapiens_hsa006000.77822207
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77618306
57TNF signaling pathway_Homo sapiens_hsa046680.77030474
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76726669
59GnRH signaling pathway_Homo sapiens_hsa049120.76411107
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75245909
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.74919111
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73984955
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73939112
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73536974
65Cocaine addiction_Homo sapiens_hsa050300.72939556
66Ether lipid metabolism_Homo sapiens_hsa005650.72871938
67Rheumatoid arthritis_Homo sapiens_hsa053230.70127096
68Pancreatic cancer_Homo sapiens_hsa052120.69639874
69MAPK signaling pathway_Homo sapiens_hsa040100.68857649
70Chronic myeloid leukemia_Homo sapiens_hsa052200.68417220
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.67485319
72Shigellosis_Homo sapiens_hsa051310.66712905
73Type II diabetes mellitus_Homo sapiens_hsa049300.66538853
74Hepatitis C_Homo sapiens_hsa051600.66418136
75Notch signaling pathway_Homo sapiens_hsa043300.66315440
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.65882603
77Dopaminergic synapse_Homo sapiens_hsa047280.61693381
78Apoptosis_Homo sapiens_hsa042100.61353484
79Salmonella infection_Homo sapiens_hsa051320.57761562
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57093476
81Nicotine addiction_Homo sapiens_hsa050330.56699394
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56639699
83Long-term depression_Homo sapiens_hsa047300.56526191
84FoxO signaling pathway_Homo sapiens_hsa040680.56481133
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.55246040
86Prolactin signaling pathway_Homo sapiens_hsa049170.54642752
87Prostate cancer_Homo sapiens_hsa052150.54580480
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54470053
89Morphine addiction_Homo sapiens_hsa050320.54418395
90HTLV-I infection_Homo sapiens_hsa051660.53616702
91Choline metabolism in cancer_Homo sapiens_hsa052310.53477442
92Oxytocin signaling pathway_Homo sapiens_hsa049210.52541591
93Renal cell carcinoma_Homo sapiens_hsa052110.52482410
94Colorectal cancer_Homo sapiens_hsa052100.52209607
95GABAergic synapse_Homo sapiens_hsa047270.51937894
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.51747803
97Endocytosis_Homo sapiens_hsa041440.51129483
98ErbB signaling pathway_Homo sapiens_hsa040120.50876195
99Rap1 signaling pathway_Homo sapiens_hsa040150.48753413
100Type I diabetes mellitus_Homo sapiens_hsa049400.48681261
101Phototransduction_Homo sapiens_hsa047440.48217967
102Non-small cell lung cancer_Homo sapiens_hsa052230.47021058
103Viral myocarditis_Homo sapiens_hsa054160.46930653
104Long-term potentiation_Homo sapiens_hsa047200.46548162
105Ras signaling pathway_Homo sapiens_hsa040140.46311865
106Serotonergic synapse_Homo sapiens_hsa047260.45747901
107RNA degradation_Homo sapiens_hsa030180.42371501
108Axon guidance_Homo sapiens_hsa043600.42052308
109RNA polymerase_Homo sapiens_hsa030200.41617794
110VEGF signaling pathway_Homo sapiens_hsa043700.40454912
111Inositol phosphate metabolism_Homo sapiens_hsa005620.39575525
112MicroRNAs in cancer_Homo sapiens_hsa052060.39299054
113Glutamatergic synapse_Homo sapiens_hsa047240.38485516
114Small cell lung cancer_Homo sapiens_hsa052220.38166801
115Regulation of autophagy_Homo sapiens_hsa041400.37951603
116Viral carcinogenesis_Homo sapiens_hsa052030.37782073
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36026272
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35845089
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35017462
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34573689
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34461218
122Legionellosis_Homo sapiens_hsa051340.34451018
123Dorso-ventral axis formation_Homo sapiens_hsa043200.34389568
124Circadian entrainment_Homo sapiens_hsa047130.33893388
125Olfactory transduction_Homo sapiens_hsa047400.33869581

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