POU2F3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)8.74249112
2hemidesmosome assembly (GO:0031581)8.53172729
3multicellular organismal water homeostasis (GO:0050891)7.00858629
4keratinocyte proliferation (GO:0043616)6.75951589
5* keratinocyte differentiation (GO:0030216)6.71761603
6viral transcription (GO:0019083)6.47393637
7keratinocyte development (GO:0003334)6.35268805
8sphingoid metabolic process (GO:0046519)6.26485714
9bundle of His cell to Purkinje myocyte communication (GO:0086069)6.18146759
10translational termination (GO:0006415)6.16185419
11ribosomal small subunit biogenesis (GO:0042274)6.13413816
12water homeostasis (GO:0030104)6.03241413
13sphingosine metabolic process (GO:0006670)5.76567589
14interferon-gamma secretion (GO:0072643)5.62996090
15hair cycle (GO:0042633)5.49195209
16molting cycle (GO:0042303)5.49195209
17maturation of SSU-rRNA (GO:0030490)5.46958236
18diol metabolic process (GO:0034311)5.35835820
19* epidermal cell differentiation (GO:0009913)5.33908890
20translational elongation (GO:0006414)5.16048704
21phosphatidylinositol acyl-chain remodeling (GO:0036149)5.04006894
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.96668147
23protein targeting to ER (GO:0045047)4.87755536
24ribosomal small subunit assembly (GO:0000028)4.87075772
25cotranslational protein targeting to membrane (GO:0006613)4.84704828
26viral life cycle (GO:0019058)4.77813832
27positive regulation of interleukin-8 secretion (GO:2000484)4.76571019
28intestinal epithelial cell development (GO:0060576)4.73626843
29cellular protein complex disassembly (GO:0043624)4.69418279
30regulation of phospholipase A2 activity (GO:0032429)4.69345409
31establishment of protein localization to endoplasmic reticulum (GO:0072599)4.69192990
32* epidermis development (GO:0008544)4.68764196
33behavioral response to nicotine (GO:0035095)4.67480408
34glucosamine-containing compound catabolic process (GO:1901072)4.64392291
35peptide cross-linking (GO:0018149)4.62210067
36nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.61037951
37intermediate filament organization (GO:0045109)4.59124786
38protein localization to endoplasmic reticulum (GO:0070972)4.54102812
39cyclooxygenase pathway (GO:0019371)4.51413924
40phosphatidylserine acyl-chain remodeling (GO:0036150)4.43336217
41sulfation (GO:0051923)4.42476465
42regulation of cell proliferation involved in kidney development (GO:1901722)4.33095617
43regulation of ruffle assembly (GO:1900027)4.31734174
44cardiac right ventricle morphogenesis (GO:0003215)4.19964897
45regulation of chemokine secretion (GO:0090196)4.14685804
46translational initiation (GO:0006413)4.11583563
47ribosomal large subunit biogenesis (GO:0042273)4.08268651
48cornea development in camera-type eye (GO:0061303)4.00377806
49long-chain fatty acid biosynthetic process (GO:0042759)3.99774631
50tryptophan catabolic process (GO:0006569)3.98354059
51indole-containing compound catabolic process (GO:0042436)3.98354059
52indolalkylamine catabolic process (GO:0046218)3.98354059
53negative regulation of keratinocyte proliferation (GO:0010839)3.97993406
54protein complex disassembly (GO:0043241)3.97668154
55indolalkylamine metabolic process (GO:0006586)3.92416669
56phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.91462536
57tryptophan metabolic process (GO:0006568)3.88059135
58negative regulation of cell fate commitment (GO:0010454)3.85857864
59prostaglandin biosynthetic process (GO:0001516)3.84992224
60prostanoid biosynthetic process (GO:0046457)3.84992224
61kynurenine metabolic process (GO:0070189)3.84637137
62lipoxygenase pathway (GO:0019372)3.83487332
63water-soluble vitamin biosynthetic process (GO:0042364)3.83048197
64phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.77935481
65fucose catabolic process (GO:0019317)3.71995594
66L-fucose metabolic process (GO:0042354)3.71995594
67L-fucose catabolic process (GO:0042355)3.71995594
68regulation of interleukin-8 secretion (GO:2000482)3.69861198
69macromolecular complex disassembly (GO:0032984)3.65492300
70eyelid development in camera-type eye (GO:0061029)3.64390429
71prostaglandin metabolic process (GO:0006693)3.59262319
72prostanoid metabolic process (GO:0006692)3.59262319
73cell proliferation in forebrain (GO:0021846)3.58961589
74ectoderm development (GO:0007398)3.57324646
75cellular response to ATP (GO:0071318)3.52581254
76regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.43188414
77protein targeting to membrane (GO:0006612)3.41574932
78regulation of hypersensitivity (GO:0002883)3.40757128
79G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.38618004
80regulation of female receptivity (GO:0045924)3.37726839
81phosphatidylcholine acyl-chain remodeling (GO:0036151)3.37135420
82mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36395869
83mitochondrial respiratory chain complex I assembly (GO:0032981)3.36395869
84NADH dehydrogenase complex assembly (GO:0010257)3.36395869
85negative regulation of translation, ncRNA-mediated (GO:0040033)3.35724979
86regulation of translation, ncRNA-mediated (GO:0045974)3.35724979
87negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.35724979
88protein complex biogenesis (GO:0070271)3.34870529
89otic vesicle formation (GO:0030916)3.34739308
90fatty acid elongation (GO:0030497)3.34024743
91atrioventricular valve morphogenesis (GO:0003181)3.28694131
92skin morphogenesis (GO:0043589)3.27681073
93DNA deamination (GO:0045006)3.26687298
94primary alcohol catabolic process (GO:0034310)3.25776408
95reflex (GO:0060004)3.21647887
96detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.21634072
97regulation of hippo signaling (GO:0035330)3.20666894
98mitochondrial respiratory chain complex assembly (GO:0033108)3.20240725
99negative regulation of interferon-gamma production (GO:0032689)3.13654374
100regulation of keratinocyte proliferation (GO:0010837)3.10742970
101establishment of planar polarity (GO:0001736)3.09895249
102establishment of tissue polarity (GO:0007164)3.09895249
103intermediate filament cytoskeleton organization (GO:0045104)3.06458354
104intermediate filament-based process (GO:0045103)3.02218171
105positive regulation of interleukin-4 production (GO:0032753)3.01263313
106negative regulation of systemic arterial blood pressure (GO:0003085)2.98986014
107detection of bacterium (GO:0016045)2.98185338
108platelet dense granule organization (GO:0060155)2.96734976
109inflammatory response to antigenic stimulus (GO:0002437)2.93802519
110indole-containing compound metabolic process (GO:0042430)2.93510964
111detection of light stimulus involved in sensory perception (GO:0050962)2.93340192
112detection of light stimulus involved in visual perception (GO:0050908)2.93340192
113cellular response to interferon-alpha (GO:0035457)2.91702673
114GPI anchor metabolic process (GO:0006505)2.90894440
115positive regulation of chemokine secretion (GO:0090197)2.90598816
116photoreceptor cell development (GO:0042461)2.90214507
117transmission of nerve impulse (GO:0019226)2.89058350
118cellular ketone body metabolic process (GO:0046950)2.89047075
119response to pheromone (GO:0019236)2.88307905
120gland morphogenesis (GO:0022612)2.88155199
121positive regulation of epidermal cell differentiation (GO:0045606)2.87834502
122cAMP catabolic process (GO:0006198)2.87443079
123epithelial cell-cell adhesion (GO:0090136)2.87052087
124lateral sprouting from an epithelium (GO:0060601)2.85079023
125planar cell polarity pathway involved in neural tube closure (GO:0090179)2.84912478
126phosphatidylglycerol metabolic process (GO:0046471)2.83943889
127nuclear-transcribed mRNA catabolic process (GO:0000956)2.83727638
128cilium morphogenesis (GO:0060271)2.82752456
129limb bud formation (GO:0060174)2.81126211
130photoreceptor cell maintenance (GO:0045494)2.80727846
131piRNA metabolic process (GO:0034587)2.80508086
132regulation of glomerulus development (GO:0090192)2.80256276
133positive regulation of epidermis development (GO:0045684)2.80165244
134negative regulation of kidney development (GO:0090185)2.79492227
135phosphatidylserine metabolic process (GO:0006658)2.79079995
136cell-substrate junction assembly (GO:0007044)2.79065550
137preassembly of GPI anchor in ER membrane (GO:0016254)2.78739850
138positive regulation of cAMP-mediated signaling (GO:0043950)2.77052342
139oocyte development (GO:0048599)2.76615156
140cardiolipin metabolic process (GO:0032048)2.76312183
1413-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.75790865
142purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.75790865
143mRNA catabolic process (GO:0006402)2.75036712
144negative regulation of acute inflammatory response (GO:0002674)2.74754027
145negative regulation of transcription regulatory region DNA binding (GO:2000678)2.74585384
146negative regulation of cell fate specification (GO:0009996)2.73327722
147behavioral response to ethanol (GO:0048149)2.72766629
148female mating behavior (GO:0060180)2.72306579
149ketone body metabolic process (GO:1902224)2.72161047
150mannosylation (GO:0097502)2.72056749
151amine catabolic process (GO:0009310)2.69498780
152cellular biogenic amine catabolic process (GO:0042402)2.69498780
153regulation of action potential (GO:0098900)2.69016708
154regulation of neurotransmitter uptake (GO:0051580)2.68461641
155regulation of mesoderm development (GO:2000380)2.65687904
156gamma-aminobutyric acid transport (GO:0015812)2.64014242
157G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62247036
158respiratory chain complex IV assembly (GO:0008535)2.59471210
159somite development (GO:0061053)2.56135065
160cyclic nucleotide catabolic process (GO:0009214)2.54738055
161neuronal action potential (GO:0019228)2.54704063
162dorsal/ventral axis specification (GO:0009950)2.52061073
163axoneme assembly (GO:0035082)2.50990416
164eye photoreceptor cell development (GO:0042462)2.49321588
165nephron epithelium morphogenesis (GO:0072088)2.46492772
166nephron tubule morphogenesis (GO:0072078)2.46492772
167embryonic epithelial tube formation (GO:0001838)2.45540783
168spinal cord motor neuron differentiation (GO:0021522)2.42449285
169peristalsis (GO:0030432)2.41990571
170DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.41191491
171negative regulation of telomere maintenance (GO:0032205)2.41143000
172mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.40369619
173regulation of gene silencing by RNA (GO:0060966)2.40318947
174regulation of posttranscriptional gene silencing (GO:0060147)2.40318947
175regulation of gene silencing by miRNA (GO:0060964)2.40318947
176sympathetic nervous system development (GO:0048485)2.38042396
177regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.35431403
178regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.35431403
179kidney morphogenesis (GO:0060993)2.32523261
180negative regulation of multicellular organism growth (GO:0040015)2.31806494
181signal peptide processing (GO:0006465)2.31352993
182artery development (GO:0060840)2.30940563
183adaptation of signaling pathway (GO:0023058)2.30809323
184desmosome organization (GO:0002934)14.3933178
185establishment of skin barrier (GO:0061436)11.2189512
186regulation of water loss via skin (GO:0033561)10.5926794

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.93433186
2ZNF274_21170338_ChIP-Seq_K562_Hela3.54742152
3EZH2_22144423_ChIP-Seq_EOC_Human3.39104124
4P63_26484246_Chip-Seq_KERATINOCYTES_Human3.11993452
5* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.81029624
6ZNF263_19887448_ChIP-Seq_K562_Human2.74843953
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.71589210
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.57341796
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.52013826
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47034545
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.42545008
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.40787900
13GBX2_23144817_ChIP-Seq_PC3_Human2.37265388
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31866580
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.20459854
16FUS_26573619_Chip-Seq_HEK293_Human2.17500868
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.16485211
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.11026142
19TP63_17297297_ChIP-ChIP_HaCaT_Human17.3292582
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.98362145
21SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.96277286
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.96277286
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95987174
24EWS_26573619_Chip-Seq_HEK293_Human1.95216865
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.94297015
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90462686
27P300_19829295_ChIP-Seq_ESCs_Human1.89343899
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88816966
29IGF1R_20145208_ChIP-Seq_DFB_Human1.85518589
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77195606
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75395154
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.74106634
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70827242
34ER_23166858_ChIP-Seq_MCF-7_Human1.64826482
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.62481522
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59990618
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56743067
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.56522924
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.56522924
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.56522924
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.56483157
42MYC_18940864_ChIP-ChIP_HL60_Human1.54335162
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54153162
44IRF1_19129219_ChIP-ChIP_H3396_Human1.54100976
45RUNX1_27514584_Chip-Seq_MCF-7_Human1.52148542
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.51309114
47TAF15_26573619_Chip-Seq_HEK293_Human1.48640433
48SOX2_20726797_ChIP-Seq_SW620_Human1.48588032
49* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45080248
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42076469
51AR_25329375_ChIP-Seq_VCAP_Human1.40530228
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40307884
53TCF4_22108803_ChIP-Seq_LS180_Human1.39275610
54SMAD4_21799915_ChIP-Seq_A2780_Human1.38565508
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38244542
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38244542
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.36830200
58* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36651518
59STAT3_23295773_ChIP-Seq_U87_Human1.36299722
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36040246
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.35675295
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.34876431
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33987716
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.33987716
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.33489327
66RNF2_27304074_Chip-Seq_NSC_Mouse1.33224701
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32913463
68SOX2_19829295_ChIP-Seq_ESCs_Human1.32889820
69NANOG_19829295_ChIP-Seq_ESCs_Human1.32889820
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32508805
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31811450
72EST1_17652178_ChIP-ChIP_JURKAT_Human1.31276588
73CBP_20019798_ChIP-Seq_JUKART_Human1.31182513
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31182513
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.30478740
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29755772
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29516519
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29212881
79TP63_22573176_ChIP-Seq_HFKS_Human1.27791181
80TCF4_23295773_ChIP-Seq_U87_Human1.26885689
81TP53_22573176_ChIP-Seq_HFKS_Human1.26790751
82* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.26128337
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.25990663
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24388226
85ATF3_27146783_Chip-Seq_COLON_Human1.24045937
86GATA3_24758297_ChIP-Seq_MCF-7_Human1.23529154
87BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.22777712
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22557511
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22546839
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.22016895
91KLF5_25053715_ChIP-Seq_YYC3_Human1.21684628
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.21677879
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20525762
94GATA4_25053715_ChIP-Seq_YYC3_Human1.20311645
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20165087
96GATA1_22025678_ChIP-Seq_K562_Human1.19220393
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18866237
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18775573
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18366133
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18087724
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17111136
102JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16609147
103CDX2_20551321_ChIP-Seq_CACO-2_Human1.16520506
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16138928
105GATA6_25053715_ChIP-Seq_YYC3_Human1.15813597
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15761742
107HOXB7_26014856_ChIP-Seq_BT474_Human1.14787813
108REST_21632747_ChIP-Seq_MESCs_Mouse1.14656650
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.12651856
110EZH2_27294783_Chip-Seq_NPCs_Mouse1.12595797
111AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12059286
112RACK7_27058665_Chip-Seq_MCF-7_Human1.11668860
113AR_20517297_ChIP-Seq_VCAP_Human1.10665096
114NCOR_22424771_ChIP-Seq_293T_Human1.10652782
115RUNX2_22187159_ChIP-Seq_PCA_Human1.09889625
116TP53_20018659_ChIP-ChIP_R1E_Mouse1.09649079
117TP63_23658742_ChIP-Seq_EP156T_Human1.07641320
118SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07559163
119CDX2_22108803_ChIP-Seq_LS180_Human1.06390451
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.05352193
121* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.05044658
122MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04969334
123FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04740754
124ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04679989
125* ARNT_22903824_ChIP-Seq_MCF-7_Human1.01348696
126* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01101105
127CJUN_26792858_Chip-Seq_BT549_Human1.00627222
128RNF2_27304074_Chip-Seq_ESCs_Mouse1.00537294
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00316908
130HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99726919
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.99555264
132EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99425607
133FLI1_21867929_ChIP-Seq_TH2_Mouse0.99030807
134SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98375679
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97784109
136GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97613230
137UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97588212
138* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97491899
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97016658
140ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97008848
141* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96664396
142TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96136728
143NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93508956
144PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92715117
145CEBPB_22108803_ChIP-Seq_LS180_Human0.88383449
146AR_21572438_ChIP-Seq_LNCaP_Human0.88055187
147SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87789017
148* AHR_22903824_ChIP-Seq_MCF-7_Human0.87601783
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87028342
150YY1_22570637_ChIP-Seq_MALME-3M_Human0.86574198
151UBF1/2_26484160_Chip-Seq_HMECs_Human0.85996938
152SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.85887074
153FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85673979
154NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84008619
155* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.82350432
156RXR_22108803_ChIP-Seq_LS180_Human0.81768358
157PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.81446734
158ESR1_20079471_ChIP-ChIP_T-47D_Human0.81396744
159* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81106357
160EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79542169
161SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78969434
162* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.78661418
163GATA6_21074721_ChIP-Seq_CACO-2_Human0.78643230
164POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77757728
165SA1_27219007_Chip-Seq_ERYTHROID_Human0.77515952
166* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.76888988
167VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74742520
168CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.74209654
169STAT3_1855785_ChIP-Seq_MESCs_Mouse0.70286373
170P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.70046844
171TP53_16413492_ChIP-PET_HCT116_Human0.68834859
172CTCF_20526341_ChIP-Seq_ESCs_Human0.68746315
173HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.67181768
174KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.65995652
175VDR_22108803_ChIP-Seq_LS180_Human0.65544510
176SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.64530948
177SA1_27219007_Chip-Seq_Bcells_Human0.63904502
178* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.63453823
179THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.63129581
180FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62760886
181CHD1_26751641_Chip-Seq_LNCaP_Human0.62597681
182TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.62582693
183BCOR_27268052_Chip-Seq_Bcells_Human0.62527750
184HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.62359360
185ERG_21242973_ChIP-ChIP_JURKAT_Human0.62242424
186* CTCF_27219007_Chip-Seq_Bcells_Human0.61828978
187FOXM1_26456572_ChIP-Seq_MCF-7_Human0.61350698
188BCAT_22108803_ChIP-Seq_LS180_Human0.60705736
189ELK1_22589737_ChIP-Seq_MCF10A_Human0.60357375
190CLOCK_20551151_ChIP-Seq_293T_Human0.59617357
191AR_21909140_ChIP-Seq_LNCAP_Human0.59588346
192RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.59531163

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.49769806
2MP0003941_abnormal_skin_development5.51562646
3MP0005275_abnormal_skin_tensile4.84662286
4MP0010234_abnormal_vibrissa_follicle4.84539536
5MP0002254_reproductive_system_inflammat4.76964726
6MP0005501_abnormal_skin_physiology4.42212447
7MP0002060_abnormal_skin_morphology3.69237603
8MP0004885_abnormal_endolymph3.38646476
9* MP0001216_abnormal_epidermal_layer3.29753664
10MP0004381_abnormal_hair_follicle3.20173591
11MP0006292_abnormal_olfactory_placode3.16382662
12MP0000383_abnormal_hair_follicle3.15859446
13MP0000566_synostosis3.09740267
14MP0005645_abnormal_hypothalamus_physiol3.09692782
15MP0003453_abnormal_keratinocyte_physiol3.00026605
16MP0000579_abnormal_nail_morphology2.98636347
17MP0010771_integument_phenotype2.91704325
18MP0010678_abnormal_skin_adnexa2.91283400
19MP0002098_abnormal_vibrissa_morphology2.88708046
20MP0000467_abnormal_esophagus_morphology2.76553142
21MP0003195_calcinosis2.73205506
22MP0002102_abnormal_ear_morphology2.65928868
23MP0001346_abnormal_lacrimal_gland2.54383803
24MP0000647_abnormal_sebaceous_gland2.40484262
25MP0003787_abnormal_imprinting2.37258749
26MP0008877_abnormal_DNA_methylation2.36713418
27MP0005451_abnormal_body_composition2.32958507
28MP0001986_abnormal_taste_sensitivity2.26791789
29MP0001485_abnormal_pinna_reflex2.25631970
30MP0002009_preneoplasia2.15395194
31MP0000762_abnormal_tongue_morphology2.13848517
32MP0000377_abnormal_hair_follicle2.13608424
33MP0004947_skin_inflammation2.10805659
34MP0010352_gastrointestinal_tract_polyps2.08014595
35MP0002735_abnormal_chemical_nociception2.03771878
36MP0005551_abnormal_eye_electrophysiolog2.03270256
37MP0002876_abnormal_thyroid_physiology1.99833713
38MP0009379_abnormal_foot_pigmentation1.97915911
39MP0001188_hyperpigmentation1.96978995
40MP0009046_muscle_twitch1.96461158
41MP0005646_abnormal_pituitary_gland1.94559945
42MP0003011_delayed_dark_adaptation1.92930373
43MP0002638_abnormal_pupillary_reflex1.89486990
44MP0006276_abnormal_autonomic_nervous1.88896849
45MP0004185_abnormal_adipocyte_glucose1.88827298
46MP0006072_abnormal_retinal_apoptosis1.84030009
47MP0002938_white_spotting1.82529959
48MP0008872_abnormal_physiological_respon1.82420271
49MP0003705_abnormal_hypodermis_morpholog1.81408624
50MP0000372_irregular_coat_pigmentation1.81265610
51MP0000631_abnormal_neuroendocrine_gland1.78808096
52MP0000427_abnormal_hair_cycle1.73716582
53MP0003566_abnormal_cell_adhesion1.69512808
54MP0001968_abnormal_touch/_nociception1.65910001
55MP0005174_abnormal_tail_pigmentation1.64688338
56MP0009931_abnormal_skin_appearance1.62856251
57MP0004142_abnormal_muscle_tone1.62035820
58MP0003878_abnormal_ear_physiology1.58460291
59MP0005377_hearing/vestibular/ear_phenot1.58460291
60MP0001191_abnormal_skin_condition1.58344047
61MP0009745_abnormal_behavioral_response1.52186495
62MP0003283_abnormal_digestive_organ1.42887448
63MP0010030_abnormal_orbit_morphology1.41686404
64MP0002909_abnormal_adrenal_gland1.41431854
65MP0002653_abnormal_ependyma_morphology1.35639913
66MP0005253_abnormal_eye_physiology1.33251296
67MP0000049_abnormal_middle_ear1.32276784
68MP0002160_abnormal_reproductive_system1.30247644
69MP0002733_abnormal_thermal_nociception1.29636706
70MP0000026_abnormal_inner_ear1.29275795
71MP0002272_abnormal_nervous_system1.28437962
72MP0001501_abnormal_sleep_pattern1.27440614
73MP0002736_abnormal_nociception_after1.27341177
74MP0002837_dystrophic_cardiac_calcinosis1.26895138
75MP0004133_heterotaxia1.24239147
76MP0005023_abnormal_wound_healing1.20839616
77MP0000367_abnormal_coat/_hair1.20196258
78MP0002277_abnormal_respiratory_mucosa1.19105090
79MP0002163_abnormal_gland_morphology1.18610295
80MP0005076_abnormal_cell_differentiation1.17570045
81MP0001243_abnormal_dermal_layer1.17333087
82MP0001970_abnormal_pain_threshold1.16059999
83MP0005389_reproductive_system_phenotype1.14133756
84MP0001340_abnormal_eyelid_morphology1.13424796
85MP0003646_muscle_fatigue1.12089596
86MP0001440_abnormal_grooming_behavior1.12047309
87MP0004134_abnormal_chest_morphology1.05454225
88MP0002249_abnormal_larynx_morphology1.02400362
89MP0001905_abnormal_dopamine_level1.02321198
90MP0009780_abnormal_chondrocyte_physiolo1.02066842
91MP0001984_abnormal_olfaction0.97656102
92MP0005379_endocrine/exocrine_gland_phen0.97208798
93MP0008004_abnormal_stomach_pH0.95677167
94MP0005084_abnormal_gallbladder_morpholo0.94867418
95MP0005666_abnormal_adipose_tissue0.93998350
96MP0002928_abnormal_bile_duct0.93651539
97MP0001849_ear_inflammation0.92181892
98MP0004782_abnormal_surfactant_physiolog0.90406084
99MP0005195_abnormal_posterior_eye0.89768910
100MP0003718_maternal_effect0.89039869
101MP0002557_abnormal_social/conspecific_i0.88494071
102MP0002751_abnormal_autonomic_nervous0.88033351
103MP0000465_gastrointestinal_hemorrhage0.87967001
104MP0009053_abnormal_anal_canal0.87585282
105MP0000627_abnormal_mammary_gland0.86935173
106MP0004742_abnormal_vestibular_system0.86555533
107MP0001851_eye_inflammation0.86421300
108MP0000569_abnormal_digit_pigmentation0.85707922
109MP0000538_abnormal_urinary_bladder0.85684671
110MP0002138_abnormal_hepatobiliary_system0.85654260
111MP0003880_abnormal_central_pattern0.84887578
112MP0002752_abnormal_somatic_nervous0.84287290
113MP0002006_tumorigenesis0.83389235
114MP0008875_abnormal_xenobiotic_pharmacok0.83354901
115MP0003755_abnormal_palate_morphology0.82857646
116MP0002572_abnormal_emotion/affect_behav0.82615227
117MP0003119_abnormal_digestive_system0.82529489
118MP0001486_abnormal_startle_reflex0.80104201
119MP0004145_abnormal_muscle_electrophysio0.80081546
120MP0002166_altered_tumor_susceptibility0.76724438
121MP0005499_abnormal_olfactory_system0.76717813
122MP0005394_taste/olfaction_phenotype0.76717813
123MP0002877_abnormal_melanocyte_morpholog0.74536336
124MP0002064_seizures0.73773501
125MP0002067_abnormal_sensory_capabilities0.72898768
126MP0005410_abnormal_fertilization0.72168749
127MP0002111_abnormal_tail_morphology0.71807778
128MP0001963_abnormal_hearing_physiology0.71591229
129MP0004043_abnormal_pH_regulation0.71097577
130MP0003938_abnormal_ear_development0.70096386
131MP0003136_yellow_coat_color0.69683213
132MP0004264_abnormal_extraembryonic_tissu0.67282261
133MP0002177_abnormal_outer_ear0.63468598
134MP0000613_abnormal_salivary_gland0.63138793
135MP0000470_abnormal_stomach_morphology0.62486842
136MP0001784_abnormal_fluid_regulation0.59608235
137MP0002233_abnormal_nose_morphology0.59472168
138MP0002282_abnormal_trachea_morphology0.58160160
139MP0008007_abnormal_cellular_replicative0.56678231
140MP0002234_abnormal_pharynx_morphology0.55910559
141MP0005367_renal/urinary_system_phenotyp0.55668797
142MP0000516_abnormal_urinary_system0.55668797
143MP0004272_abnormal_basement_membrane0.55513457
144MP0004019_abnormal_vitamin_homeostasis0.54570841
145MP0003191_abnormal_cellular_cholesterol0.54492374
146MP0000678_abnormal_parathyroid_gland0.53292016
147MP0004957_abnormal_blastocyst_morpholog0.50794971
148MP0003436_decreased_susceptibility_to0.49746776
149MP0005647_abnormal_sex_gland0.49226743
150MP0009384_cardiac_valve_regurgitation0.48318201
151MP0003693_abnormal_embryo_hatching0.47292951
152MP0009250_abnormal_appendicular_skeleto0.46081131
153MP0000432_abnormal_head_morphology0.44992920
154MP0003786_premature_aging0.44712095
155MP0005375_adipose_tissue_phenotype0.43777632
156MP0010155_abnormal_intestine_physiology0.43644056
157MP0001873_stomach_inflammation0.43159616
158MP0003385_abnormal_body_wall0.41751009
159MP0003950_abnormal_plasma_membrane0.41622303
160MP0000477_abnormal_intestine_morphology0.40636037
161MP0003763_abnormal_thymus_physiology0.40529542
162MP0002095_abnormal_skin_pigmentation0.39583480
163MP0003638_abnormal_response/metabolism_0.39116864
164MP0002148_abnormal_hypersensitivity_rea0.37144649
165MP0005508_abnormal_skeleton_morphology0.36971682
166MP0003936_abnormal_reproductive_system0.35917142
167MP0004858_abnormal_nervous_system0.35769044
168MP0003315_abnormal_perineum_morphology0.35027874
169MP0008789_abnormal_olfactory_epithelium0.30450207
170MP0004197_abnormal_fetal_growth/weight/0.29722942
171MP0000428_abnormal_craniofacial_morphol0.28431055
172MP0005075_abnormal_melanosome_morpholog0.28090452
173MP0001919_abnormal_reproductive_system0.27459894
174MP0003937_abnormal_limbs/digits/tail_de0.24891792

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)8.18082823
2Plantar hyperkeratosis (HP:0007556)6.49396344
3Hypotrichosis (HP:0001006)6.45303749
4Woolly hair (HP:0002224)6.01497753
5Palmoplantar hyperkeratosis (HP:0000972)5.67731561
6Right ventricular cardiomyopathy (HP:0011663)5.59959580
7Fragile nails (HP:0001808)5.43340835
8Onycholysis (HP:0001806)5.41664530
9Palmar hyperkeratosis (HP:0010765)5.39081324
10Milia (HP:0001056)5.25273959
11Congenital ichthyosiform erythroderma (HP:0007431)5.23157630
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.03729259
13Increased IgE level (HP:0003212)4.89220080
14Parakeratosis (HP:0001036)4.51056857
15Erythema (HP:0010783)4.37050956
16Pili torti (HP:0003777)4.26409252
17Erythroderma (HP:0001019)4.25012701
18Abnormality of nail color (HP:0100643)4.19857944
19True hermaphroditism (HP:0010459)4.03800716
20Popliteal pterygium (HP:0009756)3.94849906
21Abnormality of secondary sexual hair (HP:0009888)3.94361576
22Abnormality of the axillary hair (HP:0100134)3.94361576
23Pancreatic cysts (HP:0001737)3.91404855
24Conjunctival hamartoma (HP:0100780)3.90570700
25Abnormal blistering of the skin (HP:0008066)3.83464459
26Pancreatic fibrosis (HP:0100732)3.74330066
27Nail dystrophy (HP:0008404)3.73153329
28Abnormality of cells of the erythroid lineage (HP:0012130)3.71579415
29Genetic anticipation (HP:0003743)3.71132706
30Sparse scalp hair (HP:0002209)3.69752103
31Aplasia cutis congenita (HP:0001057)3.59529218
32Stenosis of the external auditory canal (HP:0000402)3.59077717
33Pendular nystagmus (HP:0012043)3.51904866
34Thick nail (HP:0001805)3.51402837
35Sparse eyelashes (HP:0000653)3.44511753
36Congenital stationary night blindness (HP:0007642)3.41274853
37Curly hair (HP:0002212)3.35201193
38Ectropion (HP:0000656)3.31407728
39Congenital, generalized hypertrichosis (HP:0004540)3.29278011
40Corneal erosion (HP:0200020)3.24835590
41Atrophic scars (HP:0001075)3.20780796
42Reticulocytopenia (HP:0001896)3.19312202
43Hypohidrosis (HP:0000966)3.14729575
44Furrowed tongue (HP:0000221)3.13231323
45Natal tooth (HP:0000695)3.11385279
46Abnormality of the salivary glands (HP:0010286)3.11221468
47Abnormal number of erythroid precursors (HP:0012131)3.09211613
48Distal lower limb muscle weakness (HP:0009053)3.08772233
49Progressive cerebellar ataxia (HP:0002073)3.00029702
50Abnormal hemoglobin (HP:0011902)2.97363653
51Abolished electroretinogram (ERG) (HP:0000550)2.97106035
52Septate vagina (HP:0001153)2.90753242
53Hypoplastic labia majora (HP:0000059)2.90672123
54Molar tooth sign on MRI (HP:0002419)2.89834854
55Abnormality of midbrain morphology (HP:0002418)2.89834854
56Ventricular tachycardia (HP:0004756)2.87610754
57Abnormality of the renal cortex (HP:0011035)2.84631771
58Nephronophthisis (HP:0000090)2.84575146
59Advanced eruption of teeth (HP:0006288)2.82064940
60Palmoplantar keratoderma (HP:0000982)2.81661097
61Acanthosis nigricans (HP:0000956)2.80441299
62Hyporeflexia of lower limbs (HP:0002600)2.79089930
63Pterygium (HP:0001059)2.74336753
64Type II lissencephaly (HP:0007260)2.73248477
65Decreased central vision (HP:0007663)2.72779355
66Gangrene (HP:0100758)2.68601105
67Abnormality of the labia majora (HP:0012881)2.66022058
68Down-sloping shoulders (HP:0200021)2.64949737
69Gaze-evoked nystagmus (HP:0000640)2.64352213
70Ridged nail (HP:0001807)2.64101786
71Increased corneal curvature (HP:0100692)2.63253294
72Keratoconus (HP:0000563)2.63253294
73Absent rod-and cone-mediated responses on ERG (HP:0007688)2.58475557
74Pruritus (HP:0000989)2.57250254
75Abnormal rod and cone electroretinograms (HP:0008323)2.53737897
76Sclerocornea (HP:0000647)2.53566551
77Cystic liver disease (HP:0006706)2.52269332
78Alopecia of scalp (HP:0002293)2.49054208
79Skin pits (HP:0100276)2.48555806
80Methylmalonic acidemia (HP:0002912)2.47963802
81Abnormal hair laboratory examination (HP:0003328)2.47557765
82Attenuation of retinal blood vessels (HP:0007843)2.45787259
83Abnormality of the renal medulla (HP:0100957)2.45124134
84Abnormality of the gastric mucosa (HP:0004295)2.44329451
85Premature ovarian failure (HP:0008209)2.41844771
86Nasolacrimal duct obstruction (HP:0000579)2.41078070
87Abnormality of the renal collecting system (HP:0004742)2.38695322
88Macrocytic anemia (HP:0001972)2.37908614
89Renal cortical cysts (HP:0000803)2.25145793
90Concave nail (HP:0001598)2.23210934
91Areflexia of lower limbs (HP:0002522)2.21639480
92Male pseudohermaphroditism (HP:0000037)2.19490918
93Tubular atrophy (HP:0000092)2.16661018
94Hyperventilation (HP:0002883)2.13348411
95Blepharitis (HP:0000498)2.12534771
96Large for gestational age (HP:0001520)2.12266986
97Optic nerve hypoplasia (HP:0000609)2.11207438
98Congenital sensorineural hearing impairment (HP:0008527)2.07678827
99Abnormality of the pons (HP:0007361)2.06934993
100Hypoplasia of the uterus (HP:0000013)2.05741835
101Duplicated collecting system (HP:0000081)2.05456499
102Hamartoma of the eye (HP:0010568)2.05245029
103Methylmalonic aciduria (HP:0012120)2.05101540
104Increased connective tissue (HP:0009025)2.04726713
105Hypothermia (HP:0002045)2.04426856
106Hypoplasia of the pons (HP:0012110)2.04389860
107Abnormality of the nasolacrimal system (HP:0000614)2.04005928
108Septo-optic dysplasia (HP:0100842)2.03916520
109Hypodontia (HP:0000668)2.02326411
110Medial flaring of the eyebrow (HP:0010747)2.01147395
111Aplasia/Hypoplasia of the tongue (HP:0010295)2.00688080
112Acute necrotizing encephalopathy (HP:0006965)1.99848821
113Trismus (HP:0000211)1.99439269
114Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98955899
115Chronic hepatic failure (HP:0100626)1.98358012
116Abnormality of DNA repair (HP:0003254)1.97702763
117Pallor (HP:0000980)1.97593196
118Aplasia/Hypoplasia of the spleen (HP:0010451)1.97208283
119Inability to walk (HP:0002540)1.96115423
120Asplenia (HP:0001746)1.95909101
1213-Methylglutaconic aciduria (HP:0003535)1.95494677
122Oligodontia (HP:0000677)1.94223155
123Hypoplasia of dental enamel (HP:0006297)1.93466767
124Aplasia/hypoplasia of the uterus (HP:0008684)1.92425113
125Cerebellar dysplasia (HP:0007033)1.92114083
126Fatigable weakness (HP:0003473)1.91982175
127Abnormality of the neuromuscular junction (HP:0003398)1.91982175
128Aplasia/Hypoplasia of the fovea (HP:0008060)1.91913281
129Hypoplasia of the fovea (HP:0007750)1.91913281
130Dry skin (HP:0000958)1.90325955
131Decreased circulating renin level (HP:0003351)1.89898821
132Abnormality of the lacrimal duct (HP:0011481)1.89035316
133Congenital hepatic fibrosis (HP:0002612)1.88124791
134Mitochondrial inheritance (HP:0001427)1.87724666
135Retinal dysplasia (HP:0007973)1.86858324
136Oral leukoplakia (HP:0002745)1.86224167
137Severe visual impairment (HP:0001141)1.85109680
138Esophageal atresia (HP:0002032)1.84637071
139Progressive macrocephaly (HP:0004481)1.83822735
140Chorioretinal atrophy (HP:0000533)1.81942215
141Small hand (HP:0200055)1.81748346
142Morphological abnormality of the middle ear (HP:0008609)1.80573534
143Abnormality of homocysteine metabolism (HP:0010919)1.79009064
144Homocystinuria (HP:0002156)1.79009064
145Anencephaly (HP:0002323)1.78403949
146Polydipsia (HP:0001959)1.78034224
147Abnormal drinking behavior (HP:0030082)1.78034224
148Severe Myopia (HP:0011003)1.77722505
149Aplasia/Hypoplasia of the uvula (HP:0010293)1.77090136
150Increased CSF lactate (HP:0002490)1.76959153
151Fragile skin (HP:0001030)1.76044087
152Dehydration (HP:0001944)1.75906208
153Anhidrosis (HP:0000970)1.73605306
154Osteolytic defects of the phalanges of the hand (HP:0009771)1.73322045
155Osteolytic defects of the hand bones (HP:0009699)1.73322045
156Abnormality of the distal phalanges of the toes (HP:0010182)1.72806643
157Absent thumb (HP:0009777)1.72106651
158Conical tooth (HP:0000698)1.71840785
159Progressive inability to walk (HP:0002505)1.70884370
160Sex reversal (HP:0012245)1.70390823
161Abnormal sex determination (HP:0012244)1.70390823
162Ventricular fibrillation (HP:0001663)1.70112306
163Aplasia/Hypoplasia of the tibia (HP:0005772)1.70026219
164Anonychia (HP:0001798)1.68146037
165Broad-based gait (HP:0002136)1.67246787
166Hepatocellular necrosis (HP:0001404)1.67171008
167Decreased electroretinogram (ERG) amplitude (HP:0000654)1.67111220
168Eczematoid dermatitis (HP:0000976)1.66954473
169Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65693250
170Bony spicule pigmentary retinopathy (HP:0007737)1.65608803
171Hyperhidrosis (HP:0000975)1.64788613
172Abnormal mitochondria in muscle tissue (HP:0008316)1.64036670
173Abnormality of the nasal septum (HP:0000419)1.62902316
174Acute encephalopathy (HP:0006846)1.62168360
175Abnormality of the fovea (HP:0000493)1.61590144
176Goiter (HP:0000853)1.61547473
177Aplasia/Hypoplasia of the patella (HP:0006498)1.61498233
178Labial hypoplasia (HP:0000066)1.59187721
179Aplasia involving bones of the extremities (HP:0009825)1.58647795
180Aplasia involving bones of the upper limbs (HP:0009823)1.58647795
181Aplasia of the phalanges of the hand (HP:0009802)1.58647795
18211 pairs of ribs (HP:0000878)1.58508983

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.03603842
2MAPKAPK34.81682923
3RPS6KB24.26065847
4MAP3K34.15940791
5BMPR1B3.90612236
6MST43.66563339
7ADRBK23.54699169
8STK242.87086315
9FER2.76086884
10MAP3K22.72513420
11FRK2.67327022
12LATS12.52327496
13ACVR1B2.50219953
14EEF2K2.45365750
15EPHA22.45320446
16TRPM72.39897998
17MAP4K22.35706984
18TEC2.28699651
19NUAK12.19090504
20ERN12.09744799
21WNK32.08346086
22PIK3CG2.05139934
23ZAK2.01635711
24INSRR1.96775181
25MAPKAPK51.90285127
26VRK21.88077809
27TLK11.85657100
28PIM21.83062565
29PINK11.77422127
30MAPK131.76293349
31NME11.73791189
32MET1.73260089
33TAF11.66777502
34ERBB31.61265214
35VRK11.52785292
36LATS21.52092791
37OXSR11.46435799
38TAOK31.38722255
39WNK41.35978628
40EIF2AK31.31895395
41PRKCE1.31045171
42CDK31.30490766
43RPS6KA41.30174939
44LRRK21.27601150
45NME21.26201795
46TAOK11.25304923
47TNIK1.23464130
48AKT31.19448603
49STK101.18811587
50STK391.18273829
51MKNK21.18067542
52EPHA31.14023223
53CSNK1G11.13954624
54PTK2B1.13208147
55STK38L1.12080582
56TYK21.11075575
57CDK61.07328496
58BLK1.06010782
59CASK1.05525349
60FGFR21.03905398
61MAP3K111.00444359
62TIE10.99327922
63DAPK20.99250518
64PRKCG0.96695523
65EPHB20.96691092
66STK30.96202885
67PRKD20.94707252
68MKNK10.93596864
69DYRK1B0.92489345
70TRIM280.90727377
71TESK10.88655704
72MAPKAPK20.88337349
73MAP3K10.85801286
74MAPK150.84613443
75MAP3K140.81262781
76CSNK1G30.79675410
77CSNK1G20.78514299
78STK160.76716186
79MAP3K40.75174386
80TTK0.71592100
81MAP2K60.70997328
82AURKB0.69077594
83KIT0.68538480
84PLK20.68050052
85PAK30.65437678
86TXK0.64220973
87PTK60.64214783
88MAP3K90.63768946
89ILK0.63354721
90RIPK10.62806607
91FGFR40.61850423
92MAP2K20.61228526
93IKBKB0.61118380
94SGK20.60736818
95MAP2K10.60634803
96CSNK1A1L0.60442637
97IRAK10.60287034
98AURKA0.59839067
99FGFR30.58330536
100PHKG20.57362916
101PHKG10.57362916
102WEE10.56662034
103BTK0.56568898
104EIF2AK20.55492193
105HIPK20.54968090
106TTN0.52719376
107PRKCI0.51631302
108CSNK1A10.51545926
109PLK30.51366409
110GRK10.51206503
111MAP3K50.50633576
112PKN10.48824626
113RPS6KA10.48566013
114CHUK0.47181760
115ERBB20.45905464
116NTRK30.45581364
117TGFBR20.45272009
118CAMK1D0.45124380
119PRKCH0.44695934
120NTRK20.44431257
121IGF1R0.43814694
122PNCK0.43655386
123BCR0.43532072
124PRKACA0.43184437
125CAMKK20.42513005
126BRSK20.41898157
127SGK2230.41427006
128SGK4940.41427006
129CDK70.41308506
130PRKAA10.39813724
131CSNK1D0.39802888
132CDK190.38605540
133PTK20.38290969
134PRKAA20.37992384
135BMX0.37795221
136PRKCA0.34156673
137RPS6KA50.33204279
138CAMK2A0.32475367
139DYRK20.32437698
140FLT30.32136599
141EPHB10.31572120
142RPS6KA20.31421727
143MAP3K70.31002206
144CDK120.30866051
145ITK0.29670033
146MAP3K60.29451516
147PRKD10.27893263
148BRAF0.27872800
149DDR20.27121100
150OBSCN0.26602518
151STK110.26325996
152MELK0.25590183
153RAF10.24607436
154GRK70.23194799
155GRK50.22599413
156FGFR10.21740335
157DMPK0.21324289
158LIMK10.21079499
159RPS6KL10.20532207
160RPS6KC10.20532207
161MOS0.19224075
162TGFBR10.18998374
163ADRBK10.18771892
164NLK0.18223412
165CSNK1E0.17977509
166CDK40.17097483
167BUB10.16607576

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.87776734
2Cyanoamino acid metabolism_Homo sapiens_hsa004605.41118702
3Linoleic acid metabolism_Homo sapiens_hsa005914.57727460
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.38076219
5Arachidonic acid metabolism_Homo sapiens_hsa005903.68773585
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.92436710
7Phototransduction_Homo sapiens_hsa047442.88891490
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.88603613
9Sphingolipid metabolism_Homo sapiens_hsa006002.72695118
10Taste transduction_Homo sapiens_hsa047422.60946028
11Ether lipid metabolism_Homo sapiens_hsa005652.47820283
12Selenocompound metabolism_Homo sapiens_hsa004502.35513360
13Oxidative phosphorylation_Homo sapiens_hsa001902.30400029
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.27702121
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22776132
16Caffeine metabolism_Homo sapiens_hsa002322.10149293
17Protein export_Homo sapiens_hsa030602.03390243
18p53 signaling pathway_Homo sapiens_hsa041152.01882936
19Histidine metabolism_Homo sapiens_hsa003401.98441635
20Tryptophan metabolism_Homo sapiens_hsa003801.92685186
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89486664
22Nicotine addiction_Homo sapiens_hsa050331.87253346
23Phenylalanine metabolism_Homo sapiens_hsa003601.87185261
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.86559970
25Basal cell carcinoma_Homo sapiens_hsa052171.82222515
26Butanoate metabolism_Homo sapiens_hsa006501.81380421
27Nitrogen metabolism_Homo sapiens_hsa009101.72620078
28Parkinsons disease_Homo sapiens_hsa050121.57291168
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.50762845
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48001077
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46591273
32Hippo signaling pathway_Homo sapiens_hsa043901.42098676
33Fanconi anemia pathway_Homo sapiens_hsa034601.40193814
34Fatty acid elongation_Homo sapiens_hsa000621.40071168
35Adherens junction_Homo sapiens_hsa045201.40048368
36Chemical carcinogenesis_Homo sapiens_hsa052041.38139082
37Tight junction_Homo sapiens_hsa045301.36785757
38Fat digestion and absorption_Homo sapiens_hsa049751.36597243
39Morphine addiction_Homo sapiens_hsa050321.36441643
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33238563
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.32492247
42Bladder cancer_Homo sapiens_hsa052191.30015169
43Basal transcription factors_Homo sapiens_hsa030221.29959897
44Hedgehog signaling pathway_Homo sapiens_hsa043401.19713901
45Retinol metabolism_Homo sapiens_hsa008301.14793933
46VEGF signaling pathway_Homo sapiens_hsa043701.14258100
47Huntingtons disease_Homo sapiens_hsa050161.10909251
48Alzheimers disease_Homo sapiens_hsa050101.09242191
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06830161
50Glycerophospholipid metabolism_Homo sapiens_hsa005641.06604945
51ECM-receptor interaction_Homo sapiens_hsa045121.05681309
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03058491
53RNA polymerase_Homo sapiens_hsa030201.02912263
54Sulfur metabolism_Homo sapiens_hsa009201.02846512
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02406222
56Thyroid cancer_Homo sapiens_hsa052161.02352415
57Olfactory transduction_Homo sapiens_hsa047401.02013469
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99338120
59Glutamatergic synapse_Homo sapiens_hsa047240.97106787
60Insulin secretion_Homo sapiens_hsa049110.96801126
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95165003
62Tyrosine metabolism_Homo sapiens_hsa003500.94650469
63Glutathione metabolism_Homo sapiens_hsa004800.94028235
64RNA degradation_Homo sapiens_hsa030180.91496688
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89368839
66Small cell lung cancer_Homo sapiens_hsa052220.88456120
67MicroRNAs in cancer_Homo sapiens_hsa052060.88039950
68Proteoglycans in cancer_Homo sapiens_hsa052050.87157494
69Peroxisome_Homo sapiens_hsa041460.86691190
70One carbon pool by folate_Homo sapiens_hsa006700.85670394
71Pancreatic secretion_Homo sapiens_hsa049720.84214915
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.82028600
73Amoebiasis_Homo sapiens_hsa051460.82014682
74TGF-beta signaling pathway_Homo sapiens_hsa043500.81231010
75Collecting duct acid secretion_Homo sapiens_hsa049660.79748591
76GABAergic synapse_Homo sapiens_hsa047270.78813663
77Glycerolipid metabolism_Homo sapiens_hsa005610.78785477
78Circadian entrainment_Homo sapiens_hsa047130.78167683
79Hepatitis C_Homo sapiens_hsa051600.75694736
80GnRH signaling pathway_Homo sapiens_hsa049120.74113034
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72801685
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72324831
83Cardiac muscle contraction_Homo sapiens_hsa042600.72290571
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.70804550
85Calcium signaling pathway_Homo sapiens_hsa040200.70281323
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70248652
87Endometrial cancer_Homo sapiens_hsa052130.68821502
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.68606096
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67408095
90Dopaminergic synapse_Homo sapiens_hsa047280.63165316
91Propanoate metabolism_Homo sapiens_hsa006400.63015800
92Axon guidance_Homo sapiens_hsa043600.62601472
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60591565
94Toxoplasmosis_Homo sapiens_hsa051450.59901115
95Salivary secretion_Homo sapiens_hsa049700.59432217
96Wnt signaling pathway_Homo sapiens_hsa043100.59027801
97Ras signaling pathway_Homo sapiens_hsa040140.57881114
98Metabolic pathways_Homo sapiens_hsa011000.57608145
99Purine metabolism_Homo sapiens_hsa002300.56959152
100Asthma_Homo sapiens_hsa053100.56634989
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56129305
102Non-homologous end-joining_Homo sapiens_hsa034500.56046660
103Melanogenesis_Homo sapiens_hsa049160.55568057
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54623225
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53144634
106Regulation of autophagy_Homo sapiens_hsa041400.53048187
107Dorso-ventral axis formation_Homo sapiens_hsa043200.52556962
108Acute myeloid leukemia_Homo sapiens_hsa052210.52282011
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.50885615
110ABC transporters_Homo sapiens_hsa020100.49160882
111Ovarian steroidogenesis_Homo sapiens_hsa049130.48989427
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47753992
113Choline metabolism in cancer_Homo sapiens_hsa052310.47458805
114beta-Alanine metabolism_Homo sapiens_hsa004100.47424800
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47381082
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45368706
117cAMP signaling pathway_Homo sapiens_hsa040240.44496244
118Primary immunodeficiency_Homo sapiens_hsa053400.44432687
119Nucleotide excision repair_Homo sapiens_hsa034200.44395833
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.44365263
121Pathways in cancer_Homo sapiens_hsa052000.43971888
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.43927954
123Systemic lupus erythematosus_Homo sapiens_hsa053220.43909760
124Proteasome_Homo sapiens_hsa030500.42792724
125Prostate cancer_Homo sapiens_hsa052150.42049701
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41651828
127Protein digestion and absorption_Homo sapiens_hsa049740.39908456
128Staphylococcus aureus infection_Homo sapiens_hsa051500.37898482
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37019275
130PPAR signaling pathway_Homo sapiens_hsa033200.36902775
131ErbB signaling pathway_Homo sapiens_hsa040120.36173649
132Pyrimidine metabolism_Homo sapiens_hsa002400.36039911
133Fatty acid degradation_Homo sapiens_hsa000710.36021566
134Renin secretion_Homo sapiens_hsa049240.35591929
135Lysine degradation_Homo sapiens_hsa003100.34470822
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34309050
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34293186
138Non-small cell lung cancer_Homo sapiens_hsa052230.32818396
139Melanoma_Homo sapiens_hsa052180.32779578
140Folate biosynthesis_Homo sapiens_hsa007900.32606170
141Renin-angiotensin system_Homo sapiens_hsa046140.31625042
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30758040
143Notch signaling pathway_Homo sapiens_hsa043300.30684825
144Fatty acid biosynthesis_Homo sapiens_hsa000610.29660156
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29169038
146HTLV-I infection_Homo sapiens_hsa051660.28798270
147Serotonergic synapse_Homo sapiens_hsa047260.27685039
148Homologous recombination_Homo sapiens_hsa034400.26433007
149FoxO signaling pathway_Homo sapiens_hsa040680.23485095
150RNA transport_Homo sapiens_hsa030130.21645411
151Long-term depression_Homo sapiens_hsa047300.20866137
152NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20631755
153Vitamin digestion and absorption_Homo sapiens_hsa049770.20227514
154Mineral absorption_Homo sapiens_hsa049780.20216798
155Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18817453
156Adipocytokine signaling pathway_Homo sapiens_hsa049200.18157492
157Apoptosis_Homo sapiens_hsa042100.18056256
158Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17784657
159Vitamin B6 metabolism_Homo sapiens_hsa007500.16896821
160Platelet activation_Homo sapiens_hsa046110.16828572
161Circadian rhythm_Homo sapiens_hsa047100.16448172
162Rap1 signaling pathway_Homo sapiens_hsa040150.16406012
163Influenza A_Homo sapiens_hsa051640.14799390
164Epstein-Barr virus infection_Homo sapiens_hsa051690.13649700

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