POU3F1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.44418605
2central nervous system myelination (GO:0022010)6.44418605
3pyrimidine nucleobase catabolic process (GO:0006208)5.28791403
4presynaptic membrane assembly (GO:0097105)5.06232523
5neuron cell-cell adhesion (GO:0007158)5.00683656
6presynaptic membrane organization (GO:0097090)4.94535800
7viral transcription (GO:0019083)4.86915252
8long-chain fatty acid biosynthetic process (GO:0042759)4.76340057
9neuronal action potential propagation (GO:0019227)4.69690961
10translational termination (GO:0006415)4.65428940
11dendritic spine morphogenesis (GO:0060997)4.33920395
12lateral sprouting from an epithelium (GO:0060601)4.24580691
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.20983489
14positive regulation of gastrulation (GO:2000543)4.20259641
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.20111843
16postsynaptic membrane organization (GO:0001941)4.16567602
17protein localization to synapse (GO:0035418)4.16379031
18regulation of posttranscriptional gene silencing (GO:0060147)4.14494273
19regulation of gene silencing by miRNA (GO:0060964)4.14494273
20regulation of gene silencing by RNA (GO:0060966)4.14494273
21transmission of nerve impulse (GO:0019226)4.09951181
22negative regulation of neurotransmitter transport (GO:0051589)4.05910506
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.02258484
24* axon ensheathment (GO:0008366)3.99861015
25* ensheathment of neurons (GO:0007272)3.99861015
26fatty acid elongation (GO:0030497)3.97922424
27chaperone-mediated protein transport (GO:0072321)3.97066399
28regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.96787817
29* myelination (GO:0042552)3.95998468
30paraxial mesoderm development (GO:0048339)3.93030066
31nucleobase catabolic process (GO:0046113)3.88626970
32glutamate receptor signaling pathway (GO:0007215)3.88381784
33dendritic spine organization (GO:0097061)3.85670575
34negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.84502078
35vocalization behavior (GO:0071625)3.81110746
36cotranslational protein targeting to membrane (GO:0006613)3.77509139
37cerebral cortex radially oriented cell migration (GO:0021799)3.76494675
38SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.76119744
39neuron recognition (GO:0008038)3.75034130
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.74631479
41heterochromatin organization (GO:0070828)3.72776591
42translational elongation (GO:0006414)3.69104575
43protein targeting to ER (GO:0045047)3.68167899
44nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.67489997
45ribosomal small subunit assembly (GO:0000028)3.60717939
46negative regulation of neurotransmitter secretion (GO:0046929)3.59902739
47cellular protein complex disassembly (GO:0043624)3.58636481
48establishment of protein localization to endoplasmic reticulum (GO:0072599)3.55347108
49energy coupled proton transport, down electrochemical gradient (GO:0015985)3.54954878
50ATP synthesis coupled proton transport (GO:0015986)3.54954878
51maturation of SSU-rRNA (GO:0030490)3.53254930
52limb bud formation (GO:0060174)3.50625214
53thalamus development (GO:0021794)3.50475993
54ephrin receptor signaling pathway (GO:0048013)3.47798353
55planar cell polarity pathway involved in neural tube closure (GO:0090179)3.47386569
56viral life cycle (GO:0019058)3.44751416
57spinal cord development (GO:0021510)3.42586704
58synaptic transmission, glutamatergic (GO:0035249)3.39550998
59protein localization to endoplasmic reticulum (GO:0070972)3.33811974
60protein complex disassembly (GO:0043241)3.32601237
61ovulation cycle (GO:0042698)3.31952893
62adult walking behavior (GO:0007628)3.30518580
63neuron-neuron synaptic transmission (GO:0007270)3.30449181
64regulation of long-term neuronal synaptic plasticity (GO:0048169)3.29289897
65axonal fasciculation (GO:0007413)3.29273162
66forebrain neuron differentiation (GO:0021879)3.28370151
67L-amino acid import (GO:0043092)3.28019108
68regulation of glutamate secretion (GO:0014048)3.27779094
69behavioral response to nicotine (GO:0035095)3.27727294
70convergent extension (GO:0060026)3.26960351
71establishment of mitochondrion localization (GO:0051654)3.25123773
72oligodendrocyte differentiation (GO:0048709)3.24124680
73regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.22916157
74regulation of dendritic spine morphogenesis (GO:0061001)3.22786749
75regulation of neuronal synaptic plasticity (GO:0048168)3.21532262
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.19213800
77synaptic vesicle maturation (GO:0016188)3.18725426
78positive regulation of dendritic spine development (GO:0060999)3.17531061
79regulation of glutamate receptor signaling pathway (GO:1900449)3.17335136
80dopaminergic neuron differentiation (GO:0071542)3.16362572
81ribosomal small subunit biogenesis (GO:0042274)3.15275805
82keratinocyte development (GO:0003334)3.14640285
83primitive streak formation (GO:0090009)3.14630327
84synaptic vesicle exocytosis (GO:0016079)3.13921835
85macromolecular complex disassembly (GO:0032984)3.12629386
86neuronal ion channel clustering (GO:0045161)3.12481024
87positive regulation of membrane potential (GO:0045838)3.11113123
88establishment of tissue polarity (GO:0007164)3.11023727
89establishment of planar polarity (GO:0001736)3.11023727
90exploration behavior (GO:0035640)3.10583850
91urogenital system development (GO:0001655)3.07958380
92gamma-aminobutyric acid signaling pathway (GO:0007214)3.07042477
93central nervous system projection neuron axonogenesis (GO:0021952)3.06852103
94translational initiation (GO:0006413)3.06240485
95regulation of excitatory postsynaptic membrane potential (GO:0060079)3.06009974
96synaptic transmission, dopaminergic (GO:0001963)3.04156264
97pre-miRNA processing (GO:0031054)3.04043615
98regulation of collateral sprouting (GO:0048670)3.02150440
99regulation of dendritic spine development (GO:0060998)3.01915424
100negative regulation of axon extension (GO:0030517)2.99496389
101regulation of short-term neuronal synaptic plasticity (GO:0048172)2.98238702
102locomotory exploration behavior (GO:0035641)2.97667535
103apical protein localization (GO:0045176)2.97351793
104DNA damage response, detection of DNA damage (GO:0042769)2.96737869
105regulation of dopamine metabolic process (GO:0042053)2.94252734
106regulation of catecholamine metabolic process (GO:0042069)2.94252734
107short-term memory (GO:0007614)2.94109143
108positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.93278036
109positive regulation of synapse assembly (GO:0051965)2.92577486
110central nervous system neuron axonogenesis (GO:0021955)2.90719637
111regulation of translation, ncRNA-mediated (GO:0045974)2.90657257
112negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.90657257
113negative regulation of translation, ncRNA-mediated (GO:0040033)2.90657257
114G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.90633561
115protein neddylation (GO:0045116)2.90457612
116establishment of integrated proviral latency (GO:0075713)2.89414426
117sequestering of actin monomers (GO:0042989)2.88346152
118midbrain development (GO:0030901)2.85218070
119mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.85098480
120regulation of axon regeneration (GO:0048679)2.84382719
121regulation of neuron projection regeneration (GO:0070570)2.84382719
122somite development (GO:0061053)2.83605580
123somatic stem cell division (GO:0048103)2.83495617
124negative regulation of axonogenesis (GO:0050771)2.83478268
125retinal ganglion cell axon guidance (GO:0031290)2.83059407
126learning (GO:0007612)2.82639035
127mesenchymal to epithelial transition (GO:0060231)2.82498006
128regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.82335846
129positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.81976348
130regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.81331316
131long-term memory (GO:0007616)2.81005053
132layer formation in cerebral cortex (GO:0021819)2.79530341
133auditory behavior (GO:0031223)2.79166388
134cell migration in hindbrain (GO:0021535)2.79083319
135negative regulation of protein localization to cell surface (GO:2000009)2.78418281
136regulation of postsynaptic membrane potential (GO:0060078)2.77830025
137G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77735620
138substantia nigra development (GO:0021762)2.76918063
139regulation of pigment cell differentiation (GO:0050932)2.76601167
140cellular component maintenance (GO:0043954)2.76272888
141mitochondrion transport along microtubule (GO:0047497)2.75573938
142establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.75573938
143positive regulation of neurotransmitter secretion (GO:0001956)2.75280966
144cell proliferation in forebrain (GO:0021846)2.73045713
145negative regulation of synaptic transmission, GABAergic (GO:0032229)2.72522377
146post-anal tail morphogenesis (GO:0036342)2.72089828
147dendrite development (GO:0016358)2.71353922
148phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.70180889
149regulation of synaptic plasticity (GO:0048167)2.69959291
150respiratory electron transport chain (GO:0022904)2.69304092
151positive regulation of meiotic cell cycle (GO:0051446)2.69214157
152kidney morphogenesis (GO:0060993)2.68859064
153desmosome organization (GO:0002934)2.68101623
154substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.67711657
155substrate-independent telencephalic tangential migration (GO:0021826)2.67711657
156mechanosensory behavior (GO:0007638)2.67216004
157membrane assembly (GO:0071709)2.67131160
158neurotransmitter-gated ion channel clustering (GO:0072578)2.67039470
159associative learning (GO:0008306)2.65438294
160negative regulation of amino acid transport (GO:0051956)2.65365658
161keratinization (GO:0031424)2.64820782
162outer ear morphogenesis (GO:0042473)2.64551472
163regulation of vesicle fusion (GO:0031338)2.63990691
164regulation of non-canonical Wnt signaling pathway (GO:2000050)2.63470545
165electron transport chain (GO:0022900)2.62055587
166regulation of synaptic vesicle exocytosis (GO:2000300)2.61162976
167mating behavior (GO:0007617)2.60765544
168amino acid import (GO:0043090)2.60525881
169neuronal stem cell maintenance (GO:0097150)2.60451088
170lung-associated mesenchyme development (GO:0060484)2.59307505
171neurofilament cytoskeleton organization (GO:0060052)2.58568420
172cranial nerve development (GO:0021545)2.56549062
173embryonic body morphogenesis (GO:0010172)2.56189448
174chemosensory behavior (GO:0007635)2.55793704
175neuron remodeling (GO:0016322)2.55474869
176G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.55102504
177long-term synaptic potentiation (GO:0060291)2.54667153
178nuclear-transcribed mRNA catabolic process (GO:0000956)2.54058450
179positive regulation of RNA splicing (GO:0033120)2.53738342
180Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.51093055
181head development (GO:0060322)2.49150217
182protein targeting to membrane (GO:0006612)2.47752169

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.80620510
2* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.72200832
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.55918759
4GBX2_23144817_ChIP-Seq_PC3_Human3.53913779
5* EZH2_27304074_Chip-Seq_ESCs_Mouse3.19935765
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.19466554
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11110500
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10500608
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.87587312
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.87587312
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.85574442
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.84768611
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66025306
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65205626
15* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.63968125
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.63412466
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.59508226
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51678845
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40226264
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.39981772
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38513611
22SOX2_16153702_ChIP-ChIP_HESCs_Human2.26109699
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.10673796
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.10384466
25* REST_21632747_ChIP-Seq_MESCs_Mouse2.08687165
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.07469541
27* RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.07277422
28TAF15_26573619_Chip-Seq_HEK293_Human2.05772577
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.98347683
30* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96887991
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.89161785
32* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87942342
33AR_21572438_ChIP-Seq_LNCaP_Human1.85016765
34SOX2_18555785_ChIP-Seq_MESCs_Mouse1.83654568
35* CBX2_27304074_Chip-Seq_ESCs_Mouse1.83200493
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81651855
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.81330814
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80439784
39VDR_22108803_ChIP-Seq_LS180_Human1.72229405
40FUS_26573619_Chip-Seq_HEK293_Human1.71563443
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.66978161
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66520212
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.61581356
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.60221697
45RNF2_27304074_Chip-Seq_NSC_Mouse1.59805127
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56477489
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.55591086
48DROSHA_22980978_ChIP-Seq_HELA_Human1.53478289
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51579774
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50387078
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49882046
52* RING1B_27294783_Chip-Seq_NPCs_Mouse1.49129888
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48950241
54* RING1B_27294783_Chip-Seq_ESCs_Mouse1.48768848
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48736993
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47366997
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45341121
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45341121
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43253765
60NANOG_16153702_ChIP-ChIP_HESCs_Human1.37864145
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.34206711
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32194183
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31954043
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.31636687
65* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30406232
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30004680
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29755729
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28727187
69* P300_19829295_ChIP-Seq_ESCs_Human1.28238091
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25402825
71IRF1_19129219_ChIP-ChIP_H3396_Human1.24224965
72XRN2_22483619_ChIP-Seq_HELA_Human1.23389591
73* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22722112
74MYC_18940864_ChIP-ChIP_HL60_Human1.22212199
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22005458
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21281505
77MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21046932
78POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.19185859
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17114330
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15575186
81* TP53_20018659_ChIP-ChIP_R1E_Mouse1.14774100
82E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13460253
83TTF2_22483619_ChIP-Seq_HELA_Human1.12098333
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11211182
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08872495
86ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08386762
87ZNF274_21170338_ChIP-Seq_K562_Hela1.08241520
88* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08098565
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07508629
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06933191
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06816452
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06168535
93FOXM1_23109430_ChIP-Seq_U2OS_Human1.06049682
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04722202
95SMAD4_21799915_ChIP-Seq_A2780_Human1.03298295
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03252719
97GABP_17652178_ChIP-ChIP_JURKAT_Human1.02950512
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.02309009
99* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01419105
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01179338
101KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01179338
102KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01179338
103POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01070610
104GATA1_26923725_Chip-Seq_HPCs_Mouse1.00840185
105NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00692261
106* CTCF_27219007_Chip-Seq_Bcells_Human1.00110851
107TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00109392
108SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98153084
109TP53_18474530_ChIP-ChIP_U2OS_Human0.98065432
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97670145
111TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97463235
112* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97011994
113KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96596887
114LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96406885
115* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94361958
116POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93574195
117ISL1_27105846_Chip-Seq_CPCs_Mouse0.93325221
118ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93190577
119PIAS1_25552417_ChIP-Seq_VCAP_Human0.92908922
120TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92766599
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91954023
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91933711
123OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91668420
124IGF1R_20145208_ChIP-Seq_DFB_Human0.91415549
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89954484
126NANOG_18555785_Chip-Seq_ESCs_Mouse0.88860327
127P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86790797
128* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85367185
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85359581
130TP53_16413492_ChIP-PET_HCT116_Human0.83103031
131VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83028398
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82905894
133* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82540340
134EWS_26573619_Chip-Seq_HEK293_Human0.81533197
135CMYC_18555785_Chip-Seq_ESCs_Mouse0.81498899
136* JUN_21703547_ChIP-Seq_K562_Human0.81226370
137DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81075505
138* RUNX2_22187159_ChIP-Seq_PCA_Human0.80823435
139TAL1_26923725_Chip-Seq_HPCs_Mouse0.80810624
140ER_23166858_ChIP-Seq_MCF-7_Human0.80241529
141WT1_19549856_ChIP-ChIP_CCG9911_Human0.80035625
142SOX9_26525672_Chip-Seq_HEART_Mouse0.79031182
143* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79028377
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.78646781
145* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.76863756
146SMAD3_21741376_ChIP-Seq_HESCs_Human0.76732904

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.56893263
2MP0004859_abnormal_synaptic_plasticity4.42547538
3MP0004270_analgesia3.57295952
4MP0005409_darkened_coat_color3.26833228
5MP0003136_yellow_coat_color3.03848075
6MP0003635_abnormal_synaptic_transmissio3.00291204
7MP0001486_abnormal_startle_reflex2.66020357
8MP0009745_abnormal_behavioral_response2.61899909
9MP0002272_abnormal_nervous_system2.49677565
10MP0002063_abnormal_learning/memory/cond2.46043649
11MP0004381_abnormal_hair_follicle2.41763244
12* MP0000920_abnormal_myelination2.41053492
13MP0001529_abnormal_vocalization2.38162470
14MP0002064_seizures2.35341548
15MP0000778_abnormal_nervous_system2.34171812
16MP0001968_abnormal_touch/_nociception2.16858600
17MP0003890_abnormal_embryonic-extraembry2.16163541
18MP0001188_hyperpigmentation2.15945373
19MP0009379_abnormal_foot_pigmentation2.10782214
20MP0005423_abnormal_somatic_nervous2.10741235
21MP0002572_abnormal_emotion/affect_behav2.10468421
22MP0002938_white_spotting2.03736686
23MP0003329_amyloid_beta_deposits2.00826882
24MP0001905_abnormal_dopamine_level1.99202534
25MP0001293_anophthalmia1.98955229
26MP0003122_maternal_imprinting1.95977265
27MP0002734_abnormal_mechanical_nocicepti1.94389441
28MP0010030_abnormal_orbit_morphology1.93496592
29MP0006292_abnormal_olfactory_placode1.89417514
30MP0003878_abnormal_ear_physiology1.87910989
31MP0005377_hearing/vestibular/ear_phenot1.87910989
32MP0009046_muscle_twitch1.84364234
33MP0004142_abnormal_muscle_tone1.79963962
34MP0002796_impaired_skin_barrier1.77734811
35MP0000537_abnormal_urethra_morphology1.72966402
36MP0002736_abnormal_nociception_after1.72593597
37MP0004742_abnormal_vestibular_system1.71474055
38MP0000383_abnormal_hair_follicle1.67829693
39MP0003938_abnormal_ear_development1.64689256
40MP0002184_abnormal_innervation1.62880507
41MP0002733_abnormal_thermal_nociception1.55090507
42MP0004885_abnormal_endolymph1.54599769
43MP0003121_genomic_imprinting1.52538850
44MP0008569_lethality_at_weaning1.51618157
45MP0010678_abnormal_skin_adnexa1.49705895
46MP0001970_abnormal_pain_threshold1.49056401
47MP0002067_abnormal_sensory_capabilities1.48346602
48MP0001440_abnormal_grooming_behavior1.47779925
49MP0002697_abnormal_eye_size1.47382686
50MP0000955_abnormal_spinal_cord1.46856510
51* MP0002882_abnormal_neuron_morphology1.46500106
52MP0003567_abnormal_fetal_cardiomyocyte1.43634681
53MP0002822_catalepsy1.42185189
54MP0001286_abnormal_eye_development1.41195278
55MP0009053_abnormal_anal_canal1.41184595
56MP0001299_abnormal_eye_distance/1.40574832
57MP0003787_abnormal_imprinting1.37774125
58MP0002557_abnormal_social/conspecific_i1.35374831
59MP0001501_abnormal_sleep_pattern1.33915467
60MP0005187_abnormal_penis_morphology1.33707199
61MP0002735_abnormal_chemical_nociception1.30744039
62MP0002653_abnormal_ependyma_morphology1.30043072
63MP0001485_abnormal_pinna_reflex1.29075640
64MP0000579_abnormal_nail_morphology1.28348064
65MP0003123_paternal_imprinting1.26721714
66MP0000647_abnormal_sebaceous_gland1.23553584
67MP0006276_abnormal_autonomic_nervous1.22593657
68MP0003632_abnormal_nervous_system1.22195326
69* MP0003634_abnormal_glial_cell1.21918756
70MP0000566_synostosis1.20997315
71MP0005171_absent_coat_pigmentation1.20627229
72MP0005394_taste/olfaction_phenotype1.20509460
73MP0005499_abnormal_olfactory_system1.20509460
74MP0000467_abnormal_esophagus_morphology1.20092102
75* MP0002752_abnormal_somatic_nervous1.19165401
76MP0004924_abnormal_behavior1.18945856
77MP0005386_behavior/neurological_phenoty1.18945856
78MP0001346_abnormal_lacrimal_gland1.18435082
79* MP0002066_abnormal_motor_capabilities/c1.17729151
80MP0004811_abnormal_neuron_physiology1.16942452
81MP0000631_abnormal_neuroendocrine_gland1.15728105
82MP0003011_delayed_dark_adaptation1.13941002
83MP0008995_early_reproductive_senescence1.13749754
84MP0000762_abnormal_tongue_morphology1.13453221
85MP0002751_abnormal_autonomic_nervous1.11096971
86MP0009672_abnormal_birth_weight1.10610482
87MP0000026_abnormal_inner_ear1.09384809
88MP0001963_abnormal_hearing_physiology1.09336319
89MP0002102_abnormal_ear_morphology1.09284905
90MP0008789_abnormal_olfactory_epithelium1.08971356
91* MP0002152_abnormal_brain_morphology1.08587069
92MP0002229_neurodegeneration1.08044141
93MP0004145_abnormal_muscle_electrophysio1.05455335
94MP0002233_abnormal_nose_morphology1.05145648
95MP0005501_abnormal_skin_physiology1.04107591
96MP0003385_abnormal_body_wall1.03621924
97MP0003941_abnormal_skin_development1.02584457
98MP0002234_abnormal_pharynx_morphology1.00981736
99MP0002095_abnormal_skin_pigmentation0.98623144
100MP0003942_abnormal_urinary_system0.98054090
101MP0001984_abnormal_olfaction0.97640154
102MP0003861_abnormal_nervous_system0.97277080
103MP0003283_abnormal_digestive_organ0.97018764
104MP0003690_abnormal_glial_cell0.95925988
105MP0005174_abnormal_tail_pigmentation0.94612223
106MP0003315_abnormal_perineum_morphology0.93344169
107MP0003755_abnormal_palate_morphology0.91449934
108MP0008877_abnormal_DNA_methylation0.91308542
109MP0003631_nervous_system_phenotype0.89756169
110MP0000372_irregular_coat_pigmentation0.88723012
111MP0006072_abnormal_retinal_apoptosis0.87423841
112MP0010771_integument_phenotype0.87171414
113MP0002111_abnormal_tail_morphology0.86862407
114* MP0002081_perinatal_lethality0.85890233
115MP0002092_abnormal_eye_morphology0.85457998
116MP0003718_maternal_effect0.85050743
117MP0002277_abnormal_respiratory_mucosa0.82896008
118MP0004134_abnormal_chest_morphology0.82225226
119MP0002249_abnormal_larynx_morphology0.82176328
120MP0001340_abnormal_eyelid_morphology0.81114424
121MP0000049_abnormal_middle_ear0.81079711
122MP0000462_abnormal_digestive_system0.80805724
123MP0005391_vision/eye_phenotype0.80700239
124MP0008932_abnormal_embryonic_tissue0.77513016
125MP0005551_abnormal_eye_electrophysiolog0.77491284
126MP0005645_abnormal_hypothalamus_physiol0.76427943
127MP0002085_abnormal_embryonic_tissue0.76294911
128MP0001348_abnormal_lacrimal_gland0.72280939
129MP0004858_abnormal_nervous_system0.71185209
130MP0001177_atelectasis0.71046868
131MP0004133_heterotaxia0.69621770
132MP0002177_abnormal_outer_ear0.68663053
133MP0003879_abnormal_hair_cell0.67016581
134MP0008874_decreased_physiological_sensi0.66808810
135MP0001502_abnormal_circadian_rhythm0.66460365
136MP0003119_abnormal_digestive_system0.65777996
137MP0003937_abnormal_limbs/digits/tail_de0.63621766
138MP0000427_abnormal_hair_cycle0.63016684
139MP0000604_amyloidosis0.62865372
140MP0005410_abnormal_fertilization0.62727440
141MP0005195_abnormal_posterior_eye0.62153230

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.80534784
2Parakeratosis (HP:0001036)4.67949405
3Myokymia (HP:0002411)4.65252551
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.36058015
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.36058015
6Neurofibrillary tangles (HP:0002185)4.12200683
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.67104939
8Cerebral inclusion bodies (HP:0100314)3.64570066
9Action tremor (HP:0002345)3.62184564
10Reticulocytopenia (HP:0001896)3.55209683
11Abnormality of the corticospinal tract (HP:0002492)3.51815288
12Sensory axonal neuropathy (HP:0003390)3.17929931
13Partial duplication of the phalanx of hand (HP:0009999)3.17444009
14Peripheral hypomyelination (HP:0007182)3.11739530
15Focal seizures (HP:0007359)3.05034743
16Atonic seizures (HP:0010819)2.96098403
17Septo-optic dysplasia (HP:0100842)2.95278805
18Supranuclear gaze palsy (HP:0000605)2.94939640
19Termporal pattern (HP:0011008)2.89091011
20Insidious onset (HP:0003587)2.89091011
21Maternal diabetes (HP:0009800)2.87449364
22Abnormality of cells of the erythroid lineage (HP:0012130)2.85435186
23Ulnar claw (HP:0001178)2.82980820
24Absent septum pellucidum (HP:0001331)2.79951734
25Abnormality of the labia minora (HP:0012880)2.78793675
26Fragile nails (HP:0001808)2.78249914
27Esophageal atresia (HP:0002032)2.77296733
28Anophthalmia (HP:0000528)2.76761322
29Dysmetria (HP:0001310)2.74777872
30Concave nail (HP:0001598)2.72496466
31Broad-based gait (HP:0002136)2.70236563
32Bilateral microphthalmos (HP:0007633)2.69955040
33Abnormal number of erythroid precursors (HP:0012131)2.65349746
34Alacrima (HP:0000522)2.64988177
35Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.57641821
36Congenital ichthyosiform erythroderma (HP:0007431)2.56669586
37Intestinal atresia (HP:0011100)2.50279447
38High anterior hairline (HP:0009890)2.49184332
39Abnormality of the septum pellucidum (HP:0007375)2.49043596
40Rib fusion (HP:0000902)2.48705656
41Hepatoblastoma (HP:0002884)2.46074090
42Thickened helices (HP:0000391)2.45370865
43Retinal dysplasia (HP:0007973)2.44714374
44Colon cancer (HP:0003003)2.43095000
45Megalencephaly (HP:0001355)2.42885981
46Epileptic encephalopathy (HP:0200134)2.41740949
47Macrocytic anemia (HP:0001972)2.37943326
48Hemiparesis (HP:0001269)2.36830607
49Ankle clonus (HP:0011448)2.35155839
50Growth hormone deficiency (HP:0000824)2.32466670
51Spastic gait (HP:0002064)2.27625388
52Progressive cerebellar ataxia (HP:0002073)2.26799127
53Abnormal number of incisors (HP:0011064)2.25284931
54Visual hallucinations (HP:0002367)2.25078115
55Aqueductal stenosis (HP:0002410)2.24556284
56Hypoplastic pelvis (HP:0008839)2.18802898
57Split foot (HP:0001839)2.18111917
58Decreased lacrimation (HP:0000633)2.18030727
59Chin dimple (HP:0010751)2.17617463
60Cupped ear (HP:0000378)2.17405017
61Dialeptic seizures (HP:0011146)2.15749955
62Hypotrichosis (HP:0001006)2.13431398
63Abnormality of the axillary hair (HP:0100134)2.13295839
64Abnormality of secondary sexual hair (HP:0009888)2.13295839
65Labial hypoplasia (HP:0000066)2.12670040
66Sleep apnea (HP:0010535)2.12235276
67Obstructive sleep apnea (HP:0002870)2.12204015
68Abnormal sex determination (HP:0012244)2.11968241
69Sex reversal (HP:0012245)2.11968241
70Short 4th metacarpal (HP:0010044)2.11878154
71Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.11878154
72Hyperventilation (HP:0002883)2.11421538
73Increased hepatocellular lipid droplets (HP:0006565)2.10218421
74Abnormality of the lacrimal duct (HP:0011481)2.10148518
75Flat occiput (HP:0005469)2.09661486
76Bowel incontinence (HP:0002607)2.09480071
77Hemivertebrae (HP:0002937)2.08926941
78Onion bulb formation (HP:0003383)2.08871950
79Diplopia (HP:0000651)2.07703109
80Abnormality of binocular vision (HP:0011514)2.07703109
81Abnormality of the middle phalanges of the toes (HP:0010183)2.07499015
82Limb dystonia (HP:0002451)2.06297430
83Erythroderma (HP:0001019)2.06292769
84Delusions (HP:0000746)2.06016871
85Anomalous pulmonary venous return (HP:0010772)2.05914259
86Trigonocephaly (HP:0000243)2.05557264
87Anencephaly (HP:0002323)2.04164414
88Hypogonadotrophic hypogonadism (HP:0000044)2.03749672
89Akinesia (HP:0002304)2.03709600
90Coronal craniosynostosis (HP:0004440)2.03689727
91Hypoplastic female external genitalia (HP:0012815)2.02806054
92Anosmia (HP:0000458)2.01652783
93Cerebral hypomyelination (HP:0006808)2.01494695
94Pancreatic fibrosis (HP:0100732)2.01183798
95Intention tremor (HP:0002080)2.00855487
96Broad thumb (HP:0011304)1.99512278
97Asplenia (HP:0001746)1.98585936
98Humeroradial synostosis (HP:0003041)1.98552191
99Synostosis involving the elbow (HP:0003938)1.98552191
100Gaze-evoked nystagmus (HP:0000640)1.98443037
101Optic nerve hypoplasia (HP:0000609)1.97389956
102Steppage gait (HP:0003376)1.97313393
103Abnormality of the parietal bone (HP:0002696)1.97158357
104Breast aplasia (HP:0100783)1.97126716
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.96902495
106Duplication of thumb phalanx (HP:0009942)1.95097846
107Shawl scrotum (HP:0000049)1.93496362
108Triphalangeal thumb (HP:0001199)1.93227838
109Cutaneous syndactyly (HP:0012725)1.93053660
110Abnormal large intestine physiology (HP:0012700)1.92232210
111Anxiety (HP:0000739)1.91838911
112Scanning speech (HP:0002168)1.91080571
113Febrile seizures (HP:0002373)1.90337396
114Aplasia/Hypoplasia of the breasts (HP:0010311)1.88963298
115Cortical dysplasia (HP:0002539)1.87759461
116Dysdiadochokinesis (HP:0002075)1.87755285
117Amblyopia (HP:0000646)1.87692298
118Absent speech (HP:0001344)1.87510510
119Morphological abnormality of the middle ear (HP:0008609)1.87492008
120Absence seizures (HP:0002121)1.87065986
121Abnormality of the nasolacrimal system (HP:0000614)1.87048608
122Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86992991
123Oligodactyly (hands) (HP:0001180)1.86774971
124Stenosis of the external auditory canal (HP:0000402)1.86300950
125Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.85312616
126Renal hypoplasia (HP:0000089)1.85072296
127Conical tooth (HP:0000698)1.83404117
128Dynein arm defect of respiratory motile cilia (HP:0012255)1.82170562
129Absent/shortened dynein arms (HP:0200106)1.82170562
130Hyperglycinemia (HP:0002154)1.81882696
131Short hallux (HP:0010109)1.81873030
132Midline defect of the nose (HP:0004122)1.81019667
133Abnormality of the intervertebral disk (HP:0005108)1.80812569
134Nasolacrimal duct obstruction (HP:0000579)1.79538801
135Pallor (HP:0000980)1.79366716
136Abnormality of the 4th metacarpal (HP:0010012)1.78284483
137Segmental peripheral demyelination/remyelination (HP:0003481)1.78063960
138Pendular nystagmus (HP:0012043)1.76906176
139Septate vagina (HP:0001153)1.76637000
140Aplasia/Hypoplasia of the hallux (HP:0008362)1.75679714
141Cutaneous finger syndactyly (HP:0010554)1.74786124
142Partial agenesis of the corpus callosum (HP:0001338)1.74374651
143Preaxial foot polydactyly (HP:0001841)1.73977072
144Abnormality of hair growth rate (HP:0011363)1.73654275
145Slow-growing hair (HP:0002217)1.73654275
146Aplasia/Hypoplasia of the spleen (HP:0010451)1.73628390
147Leukodystrophy (HP:0002415)1.73349725
148Aplasia involving bones of the upper limbs (HP:0009823)1.73254672
149Aplasia of the phalanges of the hand (HP:0009802)1.73254672
150Aplasia involving bones of the extremities (HP:0009825)1.73254672
151Abnormality of the pulmonary veins (HP:0011718)1.72859084
152Sclerocornea (HP:0000647)1.72815566
153Patellar aplasia (HP:0006443)1.72214926
154Overfolded helix (HP:0000396)1.71017551
155Lipid accumulation in hepatocytes (HP:0006561)1.69444050
156Excessive salivation (HP:0003781)1.69270325
157Drooling (HP:0002307)1.69270325
158Oligodactyly (HP:0012165)1.69127473
159Abnormal auditory evoked potentials (HP:0006958)1.68953967
160Gastrointestinal atresia (HP:0002589)1.68667404
161Abnormality of the phalanges of the 5th finger (HP:0004213)1.68128208
162Hypoplastic labia majora (HP:0000059)1.66670541
163Mutism (HP:0002300)1.65123904
164Preaxial hand polydactyly (HP:0001177)1.64266056
165Gastroesophageal reflux (HP:0002020)1.63998337
166Abnormality of magnesium homeostasis (HP:0004921)1.63510362
167Nonprogressive disorder (HP:0003680)1.63232779
168Abnormality of the antihelix (HP:0009738)1.61745352
169Vertebral fusion (HP:0002948)1.61651674
170Acute necrotizing encephalopathy (HP:0006965)1.60933730
171Supernumerary ribs (HP:0005815)1.60615565
172Omphalocele (HP:0001539)1.60350784
173Partial duplication of thumb phalanx (HP:0009944)1.60213088
174Chorioretinal coloboma (HP:0000567)1.59597864
175Morphological abnormality of the inner ear (HP:0011390)1.59282726
176Primary amenorrhea (HP:0000786)1.58453703
177Broad phalanges of the hand (HP:0009768)1.58000487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.54295600
2TNIK3.57825950
3CASK3.27376216
4STK393.16761470
5VRK22.75433917
6CDK192.71701272
7MARK12.59962112
8OXSR12.56734095
9RIPK42.33492870
10PRPF4B2.30541192
11PNCK2.29886260
12TAF12.27717042
13NTRK32.17096178
14CDC72.14427425
15WNK31.96792607
16MKNK21.94966248
17DYRK31.89661920
18PBK1.87003154
19BUB11.83798410
20MAP3K101.82389167
21MUSK1.79037945
22MAP3K91.72802995
23MKNK11.68130313
24BCR1.64646289
25UHMK11.63189464
26FGR1.58241777
27PKN11.56432085
28BRD41.56127732
29MINK11.56013114
30VRK11.44050891
31MAP2K71.43151963
32PASK1.39210740
33CAMK2B1.37799123
34MAPKAPK51.37660766
35DYRK21.37237334
36CDK51.27684759
37NTRK11.24171058
38BMPR21.22964569
39CSNK1G31.20840777
40PLK21.20196572
41TNK21.19257912
42NME11.16967489
43MAPK131.16131215
44PAK61.16103794
45FES1.15597797
46EPHB11.11960567
47STK241.11011851
48GRK51.10478483
49CDK121.09714867
50DYRK1B1.07999988
51WEE11.07217204
52CAMK2A1.07064861
53NTRK21.06129969
54CLK11.05247650
55MAP3K41.04718103
56CSNK1G21.02867261
57ADRBK20.99170345
58CAMK1G0.98885318
59LATS20.96644850
60WNK40.94869969
61CSNK1A1L0.94234314
62SGK4940.93739212
63SGK2230.93739212
64DYRK1A0.93030110
65IRAK20.92382604
66FGFR10.91666817
67GRK70.91499978
68NEK60.91044711
69MET0.90813110
70CDK140.90571850
71MAP3K120.90558758
72CSNK1G10.89014893
73TLK10.88494119
74ROCK20.86670448
75MARK20.86581490
76ARAF0.85972619
77NEK20.85970756
78KSR20.85474823
79CDK150.84112660
80CAMK1D0.83547773
81ZAK0.83069513
82TRIM280.82778852
83CDK180.81791216
84CDK11A0.80193241
85STK110.78150739
86TGFBR10.78125031
87PHKG10.76801090
88PHKG20.76801090
89LIMK10.75037693
90PTK2B0.74484247
91PINK10.74474683
92TTK0.74251181
93TYRO30.73448780
94DAPK20.71129734
95KSR10.71125655
96CAMK2D0.70487774
97PRKD20.66875913
98SIK20.65675000
99PRKCG0.65352404
100PLK30.64699340
101CAMK10.63911749
102ERBB20.63668994
103BMPR1B0.62787436
104ALK0.60841324
105MAP2K40.53726655
106MAP3K130.53331468
107ADRBK10.53299126
108STK160.52597983
109CAMK2G0.52174931
110PRKCE0.50930168
111FYN0.50654902
112ICK0.50292329
113PAK30.49656867
114CHUK0.49480063
115MAP3K110.48819813
116STK40.48544975
117CDK20.47885071
118MAP3K20.47675104
119MATK0.46713632
120SGK20.46546135
121FER0.46480603
122CHEK20.45929998
123PLK10.44624170
124PLK40.44416844
125ABL20.44329063
126DAPK30.44271317
127EPHB20.42018807
128AURKA0.41616343
129CSNK1E0.41266514
130CSNK1D0.41139046
131FGFR20.41031820
132NUAK10.40153708
133PRKDC0.37823704
134CSNK1A10.37677351
135RPS6KA50.37468911
136PRKCQ0.37066075
137GSK3B0.36640046
138MAPK90.36406470
139IRAK10.36340167
140ATR0.34592276
141CDK10.34230039
142PRKCZ0.33850862
143RAF10.33452370
144PRKACA0.32885538
145SRPK10.32825837
146EIF2AK20.32799532
147LATS10.32071777
148ATM0.31727608
149BRAF0.30791865
150MAPK140.30132153
151AURKB0.29789547
152AKT10.28792901

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.25072559
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.60428495
3Glutamatergic synapse_Homo sapiens_hsa047242.58586983
4Long-term potentiation_Homo sapiens_hsa047202.41991439
5Axon guidance_Homo sapiens_hsa043602.36532136
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30648890
7Serotonergic synapse_Homo sapiens_hsa047262.18398202
8Long-term depression_Homo sapiens_hsa047302.13742020
9Circadian entrainment_Homo sapiens_hsa047132.10186864
10Morphine addiction_Homo sapiens_hsa050322.03172605
11Oxidative phosphorylation_Homo sapiens_hsa001901.93709347
12Amphetamine addiction_Homo sapiens_hsa050311.92991411
13GABAergic synapse_Homo sapiens_hsa047271.89432206
14Salivary secretion_Homo sapiens_hsa049701.84006604
15Dopaminergic synapse_Homo sapiens_hsa047281.80096390
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.74984431
17Olfactory transduction_Homo sapiens_hsa047401.74307331
18Mismatch repair_Homo sapiens_hsa034301.72611406
19Phototransduction_Homo sapiens_hsa047441.72540968
20Alzheimers disease_Homo sapiens_hsa050101.65786314
21Ether lipid metabolism_Homo sapiens_hsa005651.63417942
22Synaptic vesicle cycle_Homo sapiens_hsa047211.59458972
23Ribosome_Homo sapiens_hsa030101.58383296
24Protein export_Homo sapiens_hsa030601.53238927
25Cholinergic synapse_Homo sapiens_hsa047251.49795548
26Steroid biosynthesis_Homo sapiens_hsa001001.48606455
27Renin secretion_Homo sapiens_hsa049241.48283946
28Parkinsons disease_Homo sapiens_hsa050121.46585879
29Calcium signaling pathway_Homo sapiens_hsa040201.44216268
30Fatty acid elongation_Homo sapiens_hsa000621.43206411
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.43020421
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42274598
33Gap junction_Homo sapiens_hsa045401.39528851
34Melanogenesis_Homo sapiens_hsa049161.36558328
35Homologous recombination_Homo sapiens_hsa034401.35760943
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34161825
37Taste transduction_Homo sapiens_hsa047421.33514208
38Gastric acid secretion_Homo sapiens_hsa049711.33490444
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32414213
40DNA replication_Homo sapiens_hsa030301.31249567
41Cocaine addiction_Homo sapiens_hsa050301.28306313
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23984651
43Oxytocin signaling pathway_Homo sapiens_hsa049211.23920063
44mRNA surveillance pathway_Homo sapiens_hsa030151.18886592
45GnRH signaling pathway_Homo sapiens_hsa049121.18469596
46Basal transcription factors_Homo sapiens_hsa030221.17401061
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17066237
48Sphingolipid metabolism_Homo sapiens_hsa006001.15335948
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13824965
50RNA degradation_Homo sapiens_hsa030181.13736500
51Huntingtons disease_Homo sapiens_hsa050161.12975770
52Cardiac muscle contraction_Homo sapiens_hsa042601.10294226
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07820864
54Non-homologous end-joining_Homo sapiens_hsa034501.06535818
55Proteasome_Homo sapiens_hsa030501.06207944
56ErbB signaling pathway_Homo sapiens_hsa040121.06002386
57Hedgehog signaling pathway_Homo sapiens_hsa043401.01816779
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01557585
59Wnt signaling pathway_Homo sapiens_hsa043100.98642005
60RNA transport_Homo sapiens_hsa030130.98296589
61Ras signaling pathway_Homo sapiens_hsa040140.97696696
62Alcoholism_Homo sapiens_hsa050340.96741986
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.96414670
64Basal cell carcinoma_Homo sapiens_hsa052170.94442274
65Collecting duct acid secretion_Homo sapiens_hsa049660.92089876
66RNA polymerase_Homo sapiens_hsa030200.90970999
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90320829
68cAMP signaling pathway_Homo sapiens_hsa040240.87811960
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85973354
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85647068
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85505701
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.84578897
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82228351
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.81110993
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80870067
76Notch signaling pathway_Homo sapiens_hsa043300.80734584
77Cell cycle_Homo sapiens_hsa041100.80159120
78Choline metabolism in cancer_Homo sapiens_hsa052310.77910785
79Linoleic acid metabolism_Homo sapiens_hsa005910.76479916
80Insulin secretion_Homo sapiens_hsa049110.76401119
81VEGF signaling pathway_Homo sapiens_hsa043700.76399821
82Glioma_Homo sapiens_hsa052140.75857573
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74847900
84Tight junction_Homo sapiens_hsa045300.73768702
85Renal cell carcinoma_Homo sapiens_hsa052110.73650154
86Oocyte meiosis_Homo sapiens_hsa041140.73260664
87African trypanosomiasis_Homo sapiens_hsa051430.72837372
88Pancreatic secretion_Homo sapiens_hsa049720.70552744
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70496523
90Base excision repair_Homo sapiens_hsa034100.68410635
91Nucleotide excision repair_Homo sapiens_hsa034200.68078978
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67676208
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.66744751
94Dorso-ventral axis formation_Homo sapiens_hsa043200.66345208
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63761119
96MAPK signaling pathway_Homo sapiens_hsa040100.62973763
97Systemic lupus erythematosus_Homo sapiens_hsa053220.62506009
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61957533
99Estrogen signaling pathway_Homo sapiens_hsa049150.61776976
100MicroRNAs in cancer_Homo sapiens_hsa052060.57277465
101Rap1 signaling pathway_Homo sapiens_hsa040150.57241632
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55437843
103Pyruvate metabolism_Homo sapiens_hsa006200.55274236
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55196027
105Fanconi anemia pathway_Homo sapiens_hsa034600.54068768
106Vibrio cholerae infection_Homo sapiens_hsa051100.53750219
107Spliceosome_Homo sapiens_hsa030400.53443127
108Folate biosynthesis_Homo sapiens_hsa007900.52632412
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52247725
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51625893
111Purine metabolism_Homo sapiens_hsa002300.51125191
112Arachidonic acid metabolism_Homo sapiens_hsa005900.50824394
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50006411
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49664942
115One carbon pool by folate_Homo sapiens_hsa006700.49057297
116TGF-beta signaling pathway_Homo sapiens_hsa043500.47254071
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45882486
118Pyrimidine metabolism_Homo sapiens_hsa002400.45743786
119Tyrosine metabolism_Homo sapiens_hsa003500.45674627
120Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45282122
121Hippo signaling pathway_Homo sapiens_hsa043900.43747250
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43514276
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43196995
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42741428
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42664424
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41977016
127Adherens junction_Homo sapiens_hsa045200.38822489
128Pathways in cancer_Homo sapiens_hsa052000.37664723
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36246538
130Ovarian steroidogenesis_Homo sapiens_hsa049130.35883216
131Colorectal cancer_Homo sapiens_hsa052100.35615001
132p53 signaling pathway_Homo sapiens_hsa041150.35470328
133Metabolic pathways_Homo sapiens_hsa011000.34184633
134Vitamin digestion and absorption_Homo sapiens_hsa049770.33722750
135Melanoma_Homo sapiens_hsa052180.30139124
136Endocytosis_Homo sapiens_hsa041440.29599074
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28372333
138Prion diseases_Homo sapiens_hsa050200.28104695
139Chemokine signaling pathway_Homo sapiens_hsa040620.27322237
140Sulfur relay system_Homo sapiens_hsa041220.26888266
141Thyroid cancer_Homo sapiens_hsa052160.26534292
142Cysteine and methionine metabolism_Homo sapiens_hsa002700.23871697

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