POU3F4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.60496932
2neuron fate determination (GO:0048664)4.70397564
3regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.70109709
4neuronal stem cell maintenance (GO:0097150)4.65228112
5dendritic spine morphogenesis (GO:0060997)4.51482171
6limb bud formation (GO:0060174)4.49926465
7vocalization behavior (GO:0071625)4.44928534
8central nervous system projection neuron axonogenesis (GO:0021952)4.43570561
9cerebral cortex radially oriented cell migration (GO:0021799)4.34622306
10pyrimidine nucleobase catabolic process (GO:0006208)4.34209020
11postsynaptic membrane organization (GO:0001941)4.26034405
12axonal fasciculation (GO:0007413)4.23820942
13presynaptic membrane assembly (GO:0097105)4.22719487
14neuron recognition (GO:0008038)4.20649709
15regulation of respiratory system process (GO:0044065)4.20402754
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.14343499
17glial cell proliferation (GO:0014009)4.12770020
18positive regulation of synapse assembly (GO:0051965)4.04766038
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.01911407
20central nervous system myelination (GO:0022010)3.97044286
21axon ensheathment in central nervous system (GO:0032291)3.97044286
22somite development (GO:0061053)3.91200601
23regulation of respiratory gaseous exchange (GO:0043576)3.87378682
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.85459220
25regulation of timing of cell differentiation (GO:0048505)3.80444639
26presynaptic membrane organization (GO:0097090)3.73432307
27lateral sprouting from an epithelium (GO:0060601)3.70199553
28neurotransmitter-gated ion channel clustering (GO:0072578)3.68659186
29regulation of glutamate receptor signaling pathway (GO:1900449)3.66733841
30negative regulation of oligodendrocyte differentiation (GO:0048715)3.62281831
31nonmotile primary cilium assembly (GO:0035058)3.61584124
32cell migration in hindbrain (GO:0021535)3.58912722
33negative regulation of sodium ion transport (GO:0010766)3.57291051
34regulation of development, heterochronic (GO:0040034)3.57038931
35prepulse inhibition (GO:0060134)3.51537906
36hindbrain development (GO:0030902)3.48456415
37kidney morphogenesis (GO:0060993)3.47830846
38glutamate receptor signaling pathway (GO:0007215)3.44810691
39synaptic transmission, glutamatergic (GO:0035249)3.41245499
40cell proliferation in forebrain (GO:0021846)3.38564191
41innervation (GO:0060384)3.38184142
42central nervous system neuron axonogenesis (GO:0021955)3.36756099
43positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.34923748
44positive regulation of vascular permeability (GO:0043117)3.34805124
45regulation of oligodendrocyte differentiation (GO:0048713)3.34640560
46regulation of synapse assembly (GO:0051963)3.34177556
47protein localization to synapse (GO:0035418)3.34115818
48substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.33911158
49substrate-independent telencephalic tangential migration (GO:0021826)3.33911158
50startle response (GO:0001964)3.29418827
51auditory behavior (GO:0031223)3.29137138
52otic vesicle formation (GO:0030916)3.23446514
53sequestering of actin monomers (GO:0042989)3.22388210
54dopaminergic neuron differentiation (GO:0071542)3.21478544
55positive regulation of synaptic transmission, GABAergic (GO:0032230)3.19137370
56righting reflex (GO:0060013)3.17066577
57negative regulation of axon extension (GO:0030517)3.15566650
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14710367
59response to auditory stimulus (GO:0010996)3.13341115
60gamma-aminobutyric acid transport (GO:0015812)3.12997540
61negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.10779038
62neuron-neuron synaptic transmission (GO:0007270)3.10739365
63dendrite morphogenesis (GO:0048813)3.09778051
64negative regulation of dendrite development (GO:2000171)3.08325975
65mechanosensory behavior (GO:0007638)3.05618676
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02450720
67neuroblast proliferation (GO:0007405)3.02072702
68synapse assembly (GO:0007416)3.02045623
69positive regulation of oligodendrocyte differentiation (GO:0048714)3.01259179
70retinal ganglion cell axon guidance (GO:0031290)3.00930586
71astrocyte differentiation (GO:0048708)3.00771236
72regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.00491793
73regulation of synapse structural plasticity (GO:0051823)3.00473333
74heart valve formation (GO:0003188)3.00154582
75nucleobase catabolic process (GO:0046113)2.99236263
76cranial nerve morphogenesis (GO:0021602)2.98755074
77adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.97953024
78regulation of synaptic transmission, glutamatergic (GO:0051966)2.97036312
79drinking behavior (GO:0042756)2.96409147
80calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.95335879
81spinal cord development (GO:0021510)2.95081950
82sympathetic nervous system development (GO:0048485)2.94895794
83positive regulation of amino acid transport (GO:0051957)2.93790297
84limb development (GO:0060173)2.91929339
85appendage development (GO:0048736)2.91929339
86microtubule depolymerization (GO:0007019)2.91542012
87negative regulation of synaptic transmission, GABAergic (GO:0032229)2.89531247
88hippocampus development (GO:0021766)2.89468944
89neuronal action potential propagation (GO:0019227)2.88168280
90atrial cardiac muscle cell action potential (GO:0086014)2.87695784
91transmission of nerve impulse (GO:0019226)2.85664113
92establishment of mitochondrion localization (GO:0051654)2.85645647
93behavioral response to nicotine (GO:0035095)2.84675241
94neuron migration (GO:0001764)2.84309115
95* forebrain neuron differentiation (GO:0021879)2.83994767
96neuron fate specification (GO:0048665)2.83993160
97establishment of tissue polarity (GO:0007164)2.83707497
98establishment of planar polarity (GO:0001736)2.83707497
99cerebral cortex cell migration (GO:0021795)2.83503915
100layer formation in cerebral cortex (GO:0021819)2.83397187
101G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.82998645
102positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.82022335
103cochlea development (GO:0090102)2.81381828
104locomotory exploration behavior (GO:0035641)2.80206241
105forebrain neuron development (GO:0021884)2.78976309
106midbrain development (GO:0030901)2.78868137
107cellular response to cholesterol (GO:0071397)2.78403017
108negative regulation of astrocyte differentiation (GO:0048712)2.76299127
109head development (GO:0060322)2.74915908
110regulation of synapse organization (GO:0050807)2.74852491
111response to histamine (GO:0034776)2.74324507
112negative regulation of axon guidance (GO:1902668)2.72369899
113detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.70236933
114negative regulation of gliogenesis (GO:0014014)2.69950805
115regulation of short-term neuronal synaptic plasticity (GO:0048172)2.68546297
116positive regulation of gastrulation (GO:2000543)2.67698465
117positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.67634625
118reflex (GO:0060004)2.65538796
119central nervous system neuron development (GO:0021954)2.64033071
120positive regulation of neuroblast proliferation (GO:0002052)2.63620267
121negative regulation of cytosolic calcium ion concentration (GO:0051481)2.63501003
122exploration behavior (GO:0035640)2.62614793
123negative regulation of glial cell differentiation (GO:0045686)2.62526096
124regulation of synaptic transmission, GABAergic (GO:0032228)2.62428482
125cerebellum development (GO:0021549)2.61877816
126thalamus development (GO:0021794)2.61686323
127membrane hyperpolarization (GO:0060081)2.60926642
128neural tube formation (GO:0001841)2.60866900
129dendrite development (GO:0016358)2.60234449
130behavioral response to ethanol (GO:0048149)2.59079966
131olfactory bulb development (GO:0021772)2.53292752
132smoothened signaling pathway (GO:0007224)2.52875514
133regulation of microtubule-based movement (GO:0060632)2.52433822
134neuron fate commitment (GO:0048663)2.50232179
135intraciliary transport (GO:0042073)2.49320693
136neuronal action potential (GO:0019228)2.46950357
137epithelial cilium movement (GO:0003351)2.44840054
138neural precursor cell proliferation (GO:0061351)2.42791657
139cilium assembly (GO:0042384)2.41222961
140cell differentiation in spinal cord (GO:0021515)2.41146540

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.06833360
2GBX2_23144817_ChIP-Seq_PC3_Human3.68819122
3EZH2_27304074_Chip-Seq_ESCs_Mouse3.14939183
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.13023358
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.86868768
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86542281
7* CBX2_27304074_Chip-Seq_ESCs_Mouse2.79624269
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69511372
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63825880
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63825880
11* EED_16625203_ChIP-ChIP_MESCs_Mouse2.61643779
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61390431
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59151793
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54446458
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49299848
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.41008542
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.36265854
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35100205
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25521353
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.23073520
21* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.20430650
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17360753
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06860090
24REST_21632747_ChIP-Seq_MESCs_Mouse2.04476632
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02135877
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00243512
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99332179
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99289637
29IGF1R_20145208_ChIP-Seq_DFB_Human1.96905326
30* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.95893265
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91896798
32RNF2_27304074_Chip-Seq_NSC_Mouse1.88801500
33AR_21572438_ChIP-Seq_LNCaP_Human1.81759751
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81615359
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.81223047
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78595339
37* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.70061757
38P300_19829295_ChIP-Seq_ESCs_Human1.68188681
39* EWS_26573619_Chip-Seq_HEK293_Human1.65373609
40TAF15_26573619_Chip-Seq_HEK293_Human1.60882966
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.59143801
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.52860281
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51823965
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.50545540
45DROSHA_22980978_ChIP-Seq_HELA_Human1.48238760
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44005268
47VDR_22108803_ChIP-Seq_LS180_Human1.43830625
48RING1B_27294783_Chip-Seq_NPCs_Mouse1.43665874
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.42019461
50FUS_26573619_Chip-Seq_HEK293_Human1.41917487
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40703949
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40445184
53CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40365609
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38928097
55SMAD4_21799915_ChIP-Seq_A2780_Human1.38792331
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37658009
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36994794
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36994794
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.36884662
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.35345503
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33415087
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27373052
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26729254
64* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26437004
65RARB_27405468_Chip-Seq_BRAIN_Mouse1.24491536
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23218000
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.22212876
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19980315
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18485769
70RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17614826
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17492774
72CBP_20019798_ChIP-Seq_JUKART_Human1.17492774
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15689234
74AR_25329375_ChIP-Seq_VCAP_Human1.15592671
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.13834030
76TP53_18474530_ChIP-ChIP_U2OS_Human1.13694407
77RUNX2_22187159_ChIP-Seq_PCA_Human1.13624519
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13182494
79* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12078243
80OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11667595
81* ARNT_22903824_ChIP-Seq_MCF-7_Human1.11220956
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10567250
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10547952
84SOX9_26525672_Chip-Seq_HEART_Mouse1.09913355
85* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09861924
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08956087
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07900729
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07724533
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06094251
90* SOX2_21211035_ChIP-Seq_LN229_Gbm1.05662066
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04777667
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04452011
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.03933185
94* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03436882
95ZNF274_21170338_ChIP-Seq_K562_Hela1.01951343
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01537624
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01067755
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00275306
99E2F1_18555785_Chip-Seq_ESCs_Mouse0.99993104
100IRF1_19129219_ChIP-ChIP_H3396_Human0.99936140
101RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99784612
102* AHR_22903824_ChIP-Seq_MCF-7_Human0.99224843
103STAT3_23295773_ChIP-Seq_U87_Human0.98820279
104PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96855858
105P53_22387025_ChIP-Seq_ESCs_Mouse0.96847680
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96634449
107* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96512465
108KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96290098
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96260504
110PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96216799
111* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95860656
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95798505
113ER_23166858_ChIP-Seq_MCF-7_Human0.95164608
114* AR_19668381_ChIP-Seq_PC3_Human0.94823005
115BCAT_22108803_ChIP-Seq_LS180_Human0.94122253
116* SOX2_16153702_ChIP-ChIP_HESCs_Human0.94116074
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93784136
118FLI1_27457419_Chip-Seq_LIVER_Mouse0.93496486
119CMYC_18555785_Chip-Seq_ESCs_Mouse0.93172850

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.84396907
2MP0000566_synostosis3.34248928
3MP0005423_abnormal_somatic_nervous3.08230928
4MP0006292_abnormal_olfactory_placode3.04542536
5MP0000778_abnormal_nervous_system2.84436857
6MP0004859_abnormal_synaptic_plasticity2.63775231
7MP0006276_abnormal_autonomic_nervous2.48306849
8MP0004270_analgesia2.40751363
9MP0005645_abnormal_hypothalamus_physiol2.36214243
10MP0001486_abnormal_startle_reflex2.34660639
11MP0002638_abnormal_pupillary_reflex2.33408867
12MP0003635_abnormal_synaptic_transmissio2.27369651
13MP0002063_abnormal_learning/memory/cond2.17535650
14MP0002572_abnormal_emotion/affect_behav2.14650161
15MP0009745_abnormal_behavioral_response2.10683199
16MP0003136_yellow_coat_color2.08821939
17MP0001529_abnormal_vocalization2.05601073
18MP0005646_abnormal_pituitary_gland2.02559506
19MP0002102_abnormal_ear_morphology2.00426737
20MP0004858_abnormal_nervous_system1.99933845
21MP0001188_hyperpigmentation1.94958859
22MP0002557_abnormal_social/conspecific_i1.87981456
23MP0000569_abnormal_digit_pigmentation1.87295505
24MP0002734_abnormal_mechanical_nocicepti1.84247737
25MP0002064_seizures1.81934784
26MP0003122_maternal_imprinting1.80995595
27MP0002184_abnormal_innervation1.80471099
28MP0005187_abnormal_penis_morphology1.76934403
29MP0003283_abnormal_digestive_organ1.75891231
30MP0003938_abnormal_ear_development1.75775102
31MP0002751_abnormal_autonomic_nervous1.74989511
32MP0002938_white_spotting1.73903909
33MP0001984_abnormal_olfaction1.73869157
34MP0002272_abnormal_nervous_system1.67311223
35MP0000631_abnormal_neuroendocrine_gland1.67226118
36* MP0000026_abnormal_inner_ear1.66788137
37MP0003787_abnormal_imprinting1.65146811
38MP0010030_abnormal_orbit_morphology1.64183592
39MP0002822_catalepsy1.64062882
40MP0001968_abnormal_touch/_nociception1.61940898
41MP0001502_abnormal_circadian_rhythm1.60657313
42MP0009046_muscle_twitch1.60069528
43MP0008789_abnormal_olfactory_epithelium1.56067097
44* MP0000049_abnormal_middle_ear1.55435320
45MP0002067_abnormal_sensory_capabilities1.52087417
46MP0009379_abnormal_foot_pigmentation1.48631279
47MP0002282_abnormal_trachea_morphology1.45351019
48MP0005409_darkened_coat_color1.43668782
49MP0002249_abnormal_larynx_morphology1.43425607
50MP0002735_abnormal_chemical_nociception1.41759248
51MP0005394_taste/olfaction_phenotype1.40970768
52MP0005499_abnormal_olfactory_system1.40970768
53MP0005171_absent_coat_pigmentation1.37887002
54MP0008877_abnormal_DNA_methylation1.37445598
55MP0002736_abnormal_nociception_after1.33741608
56MP0001905_abnormal_dopamine_level1.33389122
57MP0002733_abnormal_thermal_nociception1.32044605
58MP0001293_anophthalmia1.30525804
59MP0003119_abnormal_digestive_system1.29752640
60MP0000955_abnormal_spinal_cord1.29175576
61MP0010386_abnormal_urinary_bladder1.28583911
62MP0002882_abnormal_neuron_morphology1.27084671
63* MP0001963_abnormal_hearing_physiology1.26450140
64MP0003890_abnormal_embryonic-extraembry1.23180656
65MP0000647_abnormal_sebaceous_gland1.23116380
66MP0004142_abnormal_muscle_tone1.21787942
67MP0005386_behavior/neurological_phenoty1.20944108
68MP0004924_abnormal_behavior1.20944108
69MP0002152_abnormal_brain_morphology1.19759219
70MP0001970_abnormal_pain_threshold1.19531877
71MP0003937_abnormal_limbs/digits/tail_de1.18407748
72MP0005248_abnormal_Harderian_gland1.17800687
73MP0002928_abnormal_bile_duct1.17140137
74MP0005195_abnormal_posterior_eye1.14490795
75MP0005391_vision/eye_phenotype1.14291476
76MP0001440_abnormal_grooming_behavior1.13672681
77MP0003879_abnormal_hair_cell1.13307348
78MP0003861_abnormal_nervous_system1.13070919
79MP0003315_abnormal_perineum_morphology1.12502626
80MP0002653_abnormal_ependyma_morphology1.12247136
81* MP0004742_abnormal_vestibular_system1.11258478
82MP0003385_abnormal_body_wall1.09404339
83MP0005379_endocrine/exocrine_gland_phen1.08876358
84* MP0004885_abnormal_endolymph1.08277945
85MP0004811_abnormal_neuron_physiology1.04813932
86MP0002697_abnormal_eye_size1.04791173
87MP0003121_genomic_imprinting1.03818562
88MP0002752_abnormal_somatic_nervous1.02120879
89MP0003755_abnormal_palate_morphology1.02012397
90MP0003942_abnormal_urinary_system1.01280795
91MP0006072_abnormal_retinal_apoptosis1.00519079
92MP0004133_heterotaxia1.00091700
93* MP0001485_abnormal_pinna_reflex0.97617098
94* MP0002116_abnormal_craniofacial_bone0.97188918
95* MP0002066_abnormal_motor_capabilities/c0.96858026
96MP0002277_abnormal_respiratory_mucosa0.96702394
97MP0002177_abnormal_outer_ear0.92095353
98MP0000534_abnormal_ureter_morphology0.92055408
99MP0002909_abnormal_adrenal_gland0.91858275
100MP0009053_abnormal_anal_canal0.89925790
101MP0005551_abnormal_eye_electrophysiolog0.86755213
102MP0001501_abnormal_sleep_pattern0.86653383
103MP0000537_abnormal_urethra_morphology0.86573642
104MP0001299_abnormal_eye_distance/0.86299653
105MP0001986_abnormal_taste_sensitivity0.85300016
106MP0002069_abnormal_eating/drinking_beha0.85002096
107MP0001286_abnormal_eye_development0.84294290
108MP0002081_perinatal_lethality0.84198180
109MP0002234_abnormal_pharynx_morphology0.81680524
110MP0003011_delayed_dark_adaptation0.80625176
111MP0002233_abnormal_nose_morphology0.80432199
112MP0004134_abnormal_chest_morphology0.80016769
113MP0002092_abnormal_eye_morphology0.79547287
114MP0008569_lethality_at_weaning0.79534249
115MP0009250_abnormal_appendicular_skeleto0.78900568
116MP0005377_hearing/vestibular/ear_phenot0.77614317
117MP0003878_abnormal_ear_physiology0.77614317
118MP0005253_abnormal_eye_physiology0.77454030
119MP0001177_atelectasis0.75510227
120MP0002163_abnormal_gland_morphology0.75037662
121MP0003634_abnormal_glial_cell0.74586188

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)3.87766413
2Limb dystonia (HP:0002451)3.59683213
3Molar tooth sign on MRI (HP:0002419)3.35571414
4Abnormality of midbrain morphology (HP:0002418)3.35571414
5Cortical dysplasia (HP:0002539)3.31724769
6* Morphological abnormality of the middle ear (HP:0008609)3.07422944
7Septo-optic dysplasia (HP:0100842)3.04375499
8Nephronophthisis (HP:0000090)2.99463620
9Pancreatic fibrosis (HP:0100732)2.98487492
10Megalencephaly (HP:0001355)2.94229073
1111 pairs of ribs (HP:0000878)2.93467576
12Pancreatic cysts (HP:0001737)2.88162847
13Oligodactyly (hands) (HP:0001180)2.87394671
14Hyperventilation (HP:0002883)2.80735055
15Split foot (HP:0001839)2.71933078
16Pachygyria (HP:0001302)2.71600331
17Myokymia (HP:0002411)2.70859157
18Aplasia/Hypoplasia of the sternum (HP:0006714)2.67076139
19Retinal dysplasia (HP:0007973)2.66945494
20Broad-based gait (HP:0002136)2.62989087
21Abnormality of the renal medulla (HP:0100957)2.61467082
22Short 4th metacarpal (HP:0010044)2.60360606
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.60360606
24Hemiparesis (HP:0001269)2.59144587
25Febrile seizures (HP:0002373)2.56337555
26Nephrogenic diabetes insipidus (HP:0009806)2.54526894
27Type II lissencephaly (HP:0007260)2.52855934
28Epileptic encephalopathy (HP:0200134)2.45329063
29Bifid tongue (HP:0010297)2.43081492
30Tented upper lip vermilion (HP:0010804)2.42672735
31Mixed hearing impairment (HP:0000410)2.39765529
32Optic nerve hypoplasia (HP:0000609)2.37967493
33Slow-growing hair (HP:0002217)2.37395059
34Abnormality of hair growth rate (HP:0011363)2.37395059
35Focal seizures (HP:0007359)2.37089517
36Renal dysplasia (HP:0000110)2.35806330
37Volvulus (HP:0002580)2.35482655
38Bilateral microphthalmos (HP:0007633)2.35027964
39Hypoplastic iliac wings (HP:0002866)2.33592214
40Blue irides (HP:0000635)2.31123342
41Broad alveolar ridges (HP:0000187)2.30751977
42Chronic hepatic failure (HP:0100626)2.30265430
43Anencephaly (HP:0002323)2.29649605
44Anophthalmia (HP:0000528)2.29239889
45Abnormality of secondary sexual hair (HP:0009888)2.27949241
46Abnormality of the axillary hair (HP:0100134)2.27949241
47Abnormal hair whorl (HP:0010721)2.27601082
48Genital tract atresia (HP:0001827)2.25051950
49Abnormality of the aortic arch (HP:0012303)2.24582763
50Oligodactyly (HP:0012165)2.23554362
51Polyphagia (HP:0002591)2.23395692
52Protruding tongue (HP:0010808)2.21717588
53Vaginal atresia (HP:0000148)2.21572557
54Exotropia (HP:0000577)2.20094181
55Failure to thrive in infancy (HP:0001531)2.19609806
56Abnormal ciliary motility (HP:0012262)2.18926789
57Abnormal respiratory epithelium morphology (HP:0012253)2.18053905
58Abnormal respiratory motile cilium morphology (HP:0005938)2.18053905
59Sclerocornea (HP:0000647)2.17504792
60Abnormality of the 4th metacarpal (HP:0010012)2.16936894
61Esophageal atresia (HP:0002032)2.15885054
62True hermaphroditism (HP:0010459)2.15670320
63Missing ribs (HP:0000921)2.15595279
64Patellar aplasia (HP:0006443)2.15118175
65Narrow nasal bridge (HP:0000446)2.14344653
66Progressive cerebellar ataxia (HP:0002073)2.13674318
67Midline defect of the nose (HP:0004122)2.12709545
68Absent hair (HP:0002298)2.11724357
69Intestinal atresia (HP:0011100)2.11476824
70Postaxial hand polydactyly (HP:0001162)2.11456502
71Esotropia (HP:0000565)2.11113459
72Myelomeningocele (HP:0002475)2.11094278
73Lissencephaly (HP:0001339)2.10945263
74Abnormality of the intervertebral disk (HP:0005108)2.10865673
75Hepatoblastoma (HP:0002884)2.10587728
76Concave nail (HP:0001598)2.09129938
77Epileptiform EEG discharges (HP:0011182)2.08458830
78Gastrointestinal atresia (HP:0002589)2.08365044
79EEG with generalized epileptiform discharges (HP:0011198)2.06970052
80Medial flaring of the eyebrow (HP:0010747)2.06866827
81Dynein arm defect of respiratory motile cilia (HP:0012255)2.06816026
82Absent/shortened dynein arms (HP:0200106)2.06816026
83Alacrima (HP:0000522)2.06753261
84Hypsarrhythmia (HP:0002521)2.05102960
85Atelectasis (HP:0100750)2.03894093
86Drooling (HP:0002307)2.02994653
87Excessive salivation (HP:0003781)2.02994653
88Postaxial foot polydactyly (HP:0001830)2.02195399
89Gait imbalance (HP:0002141)2.01577593
90Cystic liver disease (HP:0006706)2.01315612
91Hemivertebrae (HP:0002937)2.00332572
92Renal hypoplasia (HP:0000089)2.00198633
93Aplasia involving bones of the extremities (HP:0009825)2.00136288
94Aplasia involving bones of the upper limbs (HP:0009823)2.00136288
95Aplasia of the phalanges of the hand (HP:0009802)2.00136288
96Supranuclear gaze palsy (HP:0000605)1.95735069
97Decreased lacrimation (HP:0000633)1.94638612
98Aplasia/Hypoplasia of the patella (HP:0006498)1.94380436
99Abnormality of the diencephalon (HP:0010662)1.94016115
100Growth hormone deficiency (HP:0000824)1.93371661
101Agitation (HP:0000713)1.93275076
102Inability to walk (HP:0002540)1.92806068
103Maternal diabetes (HP:0009800)1.92227102
104Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.92041358
105Rib fusion (HP:0000902)1.89916388
106Absent septum pellucidum (HP:0001331)1.89627143
107Abnormality of the labia minora (HP:0012880)1.89466085
108Abnormality of the metopic suture (HP:0005556)1.89050022
109Colon cancer (HP:0003003)1.88873138
110Abnormality of the septum pellucidum (HP:0007375)1.88657365
111Cerebellar dysplasia (HP:0007033)1.87090843
112Autism (HP:0000717)1.86583069
113Absent eyebrow (HP:0002223)1.86448692
114Sleep apnea (HP:0010535)1.86304288
115Specific learning disability (HP:0001328)1.84035477
116Narrow forehead (HP:0000341)1.83767417
117Abnormality of chromosome segregation (HP:0002916)1.83434525
118Absence seizures (HP:0002121)1.83185415
119Abnormality of the renal cortex (HP:0011035)1.83103688
120Absent speech (HP:0001344)1.81986933
121Labial hypoplasia (HP:0000066)1.81113027
122Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80252987
123Cutaneous syndactyly (HP:0012725)1.80246710
124Meningocele (HP:0002435)1.78464661
125Aplasia/Hypoplasia of the tongue (HP:0010295)1.78407168
126Degeneration of the lateral corticospinal tracts (HP:0002314)1.78222369
127Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78222369
128Cutaneous finger syndactyly (HP:0010554)1.77826872
129Abnormality of molar morphology (HP:0011070)1.77355341
130Abnormality of molar (HP:0011077)1.77355341
131Dialeptic seizures (HP:0011146)1.76846802
132Amblyopia (HP:0000646)1.76743350
133Preaxial hand polydactyly (HP:0001177)1.75977901
134Abnormality of the dental pulp (HP:0006479)1.75956346
135Hip dysplasia (HP:0001385)1.75893385
136Heterochromia iridis (HP:0001100)1.75282966
137Congenital stationary night blindness (HP:0007642)1.73859737
138Hyperthyroidism (HP:0000836)1.73773069
139Stereotypic behavior (HP:0000733)1.73469906
140Generalized tonic-clonic seizures (HP:0002069)1.72816229
141Atonic seizures (HP:0010819)1.71277170
142Occipital encephalocele (HP:0002085)1.70341080
143Neonatal short-limb short stature (HP:0008921)1.70212322
144Congenital primary aphakia (HP:0007707)1.70100527
145Scrotal hypoplasia (HP:0000046)1.69233901
146Abnormal respiratory motile cilium physiology (HP:0012261)1.68975656
147Hypoplasia of the brainstem (HP:0002365)1.68934092
148Aplasia/Hypoplasia of the brainstem (HP:0007362)1.68934092
149Abnormality of permanent molar morphology (HP:0011071)1.68858317
150Abnormality of the dental root (HP:0006486)1.68858317
151Taurodontia (HP:0000679)1.68858317
152Genetic anticipation (HP:0003743)1.68365813
153Abnormality of the ischium (HP:0003174)1.68004091
154Hypoplastic ilia (HP:0000946)1.67439751
155Aplasia/Hypoplasia of the lens (HP:0008063)1.66855748
156Gastroesophageal reflux (HP:0002020)1.65231488
157Aplasia/Hypoplasia of the fovea (HP:0008060)1.65055754
158Hypoplasia of the fovea (HP:0007750)1.65055754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.59338843
2MARK14.46635119
3MAPK133.13712620
4EPHA43.07380578
5TNIK2.94053880
6NTRK22.69728298
7MAP2K72.56994691
8WEE12.51537328
9NTRK32.47254741
10SIK32.28716305
11EPHB22.17172435
12SIK22.06632707
13TSSK62.03955639
14STK162.01034968
15MAP3K41.98200274
16DYRK21.92604595
17WNK31.78521550
18UHMK11.77825375
19PRPF4B1.71956211
20KSR11.70930482
21BMPR1B1.67401535
22ERBB31.67116784
23EPHA31.63736814
24MKNK21.62729096
25MAP4K21.58592373
26SGK21.56308711
27CDK191.46852319
28SGK2231.46175467
29SGK4941.46175467
30YES11.45354484
31WNK41.36210652
32INSRR1.30672890
33DYRK1A1.25622403
34PHKG21.20413378
35PHKG11.20413378
36MINK11.20174495
37VRK11.18653045
38ADRBK21.15454920
39SRPK11.15096336
40IRAK21.10942149
41PINK11.10854601
42TYRO31.10354309
43BCR1.08996120
44PAK61.08143526
45DYRK31.08044271
46MKNK11.06235818
47STK391.05387792
48CDK51.03343019
49PRKCG0.98729779
50CDK30.97514986
51PNCK0.97196300
52DDR20.95086390
53CCNB10.94744609
54PKN10.94263969
55DYRK1B0.91607913
56CSNK1G30.86494002
57CSNK1G20.83914823
58FRK0.81886159
59ADRBK10.79033616
60CSNK1G10.77991458
61BRD40.77219397
62NEK60.77045697
63PLK20.76301753
64DAPK20.74007983
65TGFBR10.73945679
66BMPR20.73504604
67ERBB40.73251407
68TRIM280.72980613
69PAK30.72452510
70SGK30.71795716
71MAPK150.71468682
72CSNK1A1L0.69675586
73NUAK10.69505117
74PRKD20.68219490
75MARK20.67998117
76CAMK2A0.67652685
77MAP2K40.67206814
78GRK70.66894478
79PRKCE0.66296810
80GRK10.66258393
81PRKD30.65300486
82CAMK40.63941165
83ROCK10.63797259
84CDK180.61756850
85FES0.60718835
86CAMK2B0.60510173
87LATS10.58756506
88IRAK40.58144082
89SGK10.55923484
90IRAK10.54745111
91MAPKAPK50.54380295
92NME10.53583770
93CDK150.53567667
94ERBB20.52670945
95RPS6KA20.51975698
96PRKCZ0.51499282
97FGR0.50920490
98MUSK0.47572425
99CDK11A0.46422783
100MAP3K120.46327462
101FGFR20.45547677
102CDK140.45184962
103ROCK20.45109834
104CAMK1G0.44075529
105TAOK20.43013591
106PRKACA0.41943283
107NTRK10.40091076
108PASK0.39773487
109DAPK10.39642419
110STK110.39327907
111PLK30.38690552
112RPS6KA40.38326644
113NEK20.37975690
114PRKG10.37388565
115CSNK1A10.37287564
116CAMKK20.37050866
117BRSK20.36373880
118CSNK1E0.35839770
119OXSR10.35825280
120IRAK30.35230161
121MAPK90.35183837
122BCKDK0.35173827
123PLK40.35014439
124TLK10.34917279
125AKT20.34416661
126PRKCB0.33422802
127CDC42BPA0.32530057
128MAPK80.32485838
129PRKCH0.32304055
130RPS6KB10.31824124
131CAMKK10.30757543
132MAP3K60.30059566
133PRKACB0.27429836
134AKT30.26103795

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.45664689
2Axon guidance_Homo sapiens_hsa043602.67552260
3GABAergic synapse_Homo sapiens_hsa047272.61484127
4Morphine addiction_Homo sapiens_hsa050322.48135232
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44163099
6Cocaine addiction_Homo sapiens_hsa050302.42024563
7Glutamatergic synapse_Homo sapiens_hsa047242.40092115
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.25193981
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.23704585
10Circadian entrainment_Homo sapiens_hsa047132.11417687
11Serotonergic synapse_Homo sapiens_hsa047262.07877765
12Taste transduction_Homo sapiens_hsa047422.00747926
13Dopaminergic synapse_Homo sapiens_hsa047281.98517705
14Amphetamine addiction_Homo sapiens_hsa050311.97735902
15Basal cell carcinoma_Homo sapiens_hsa052171.96884089
16Olfactory transduction_Homo sapiens_hsa047401.89967285
17Synaptic vesicle cycle_Homo sapiens_hsa047211.88651897
18Insulin secretion_Homo sapiens_hsa049111.86677824
19Hedgehog signaling pathway_Homo sapiens_hsa043401.76276238
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71305038
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71163189
22Cholinergic synapse_Homo sapiens_hsa047251.68239452
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.65600591
24Long-term depression_Homo sapiens_hsa047301.53003690
25Wnt signaling pathway_Homo sapiens_hsa043101.52230740
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.43957398
27Melanogenesis_Homo sapiens_hsa049161.42822496
28Renin secretion_Homo sapiens_hsa049241.42741949
29Oxidative phosphorylation_Homo sapiens_hsa001901.40391810
30Gap junction_Homo sapiens_hsa045401.39575327
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.38941371
32Long-term potentiation_Homo sapiens_hsa047201.35914077
33Nitrogen metabolism_Homo sapiens_hsa009101.33465339
34Parkinsons disease_Homo sapiens_hsa050121.32951385
35Calcium signaling pathway_Homo sapiens_hsa040201.32128253
36Protein export_Homo sapiens_hsa030601.24790271
37Basal transcription factors_Homo sapiens_hsa030221.24691098
38Phototransduction_Homo sapiens_hsa047441.22306390
39Alzheimers disease_Homo sapiens_hsa050101.20382566
40Cardiac muscle contraction_Homo sapiens_hsa042601.17944640
41Type I diabetes mellitus_Homo sapiens_hsa049401.17944344
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15201777
43Linoleic acid metabolism_Homo sapiens_hsa005911.13715256
44Fanconi anemia pathway_Homo sapiens_hsa034601.13170690
45Circadian rhythm_Homo sapiens_hsa047101.12961749
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12520898
47Gastric acid secretion_Homo sapiens_hsa049711.10840523
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10400319
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.10100259
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06523497
51ErbB signaling pathway_Homo sapiens_hsa040121.03448644
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03434447
53Salivary secretion_Homo sapiens_hsa049701.02338737
54Collecting duct acid secretion_Homo sapiens_hsa049660.97543528
55cAMP signaling pathway_Homo sapiens_hsa040240.97390795
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97222120
57Alcoholism_Homo sapiens_hsa050340.97173320
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96820661
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96383018
60Spliceosome_Homo sapiens_hsa030400.93559572
61Oxytocin signaling pathway_Homo sapiens_hsa049210.93320943
62Notch signaling pathway_Homo sapiens_hsa043300.92067002
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90276038
64Huntingtons disease_Homo sapiens_hsa050160.89435109
65Butanoate metabolism_Homo sapiens_hsa006500.89420748
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84574065
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84285020
68Colorectal cancer_Homo sapiens_hsa052100.78650593
69Hippo signaling pathway_Homo sapiens_hsa043900.78009161
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77086764
71GnRH signaling pathway_Homo sapiens_hsa049120.75946669
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75899602
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73714174
74Propanoate metabolism_Homo sapiens_hsa006400.73418158
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72019632
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71599716
77Melanoma_Homo sapiens_hsa052180.68938231
78Steroid biosynthesis_Homo sapiens_hsa001000.68552307
79Endometrial cancer_Homo sapiens_hsa052130.68151027
80Peroxisome_Homo sapiens_hsa041460.66874075
81Type II diabetes mellitus_Homo sapiens_hsa049300.64987193
82Ribosome_Homo sapiens_hsa030100.59573273
83beta-Alanine metabolism_Homo sapiens_hsa004100.59016932
84Rap1 signaling pathway_Homo sapiens_hsa040150.58370105
85Ras signaling pathway_Homo sapiens_hsa040140.58240362
86Dilated cardiomyopathy_Homo sapiens_hsa054140.58103217
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56518331
88MAPK signaling pathway_Homo sapiens_hsa040100.55048913
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54988107
90Ether lipid metabolism_Homo sapiens_hsa005650.53967854
91Vibrio cholerae infection_Homo sapiens_hsa051100.53691237
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53252451
93Glioma_Homo sapiens_hsa052140.53212944
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52078109
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.51856500
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.50212834
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49559602
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48216880
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47257996
100Choline metabolism in cancer_Homo sapiens_hsa052310.46881051
101Estrogen signaling pathway_Homo sapiens_hsa049150.46763383
102Oocyte meiosis_Homo sapiens_hsa041140.45706649
103Ovarian steroidogenesis_Homo sapiens_hsa049130.45576100
104Homologous recombination_Homo sapiens_hsa034400.44363176
105Regulation of autophagy_Homo sapiens_hsa041400.43174526
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42312918
107Bile secretion_Homo sapiens_hsa049760.42200532
108Fatty acid biosynthesis_Homo sapiens_hsa000610.41030479
109Selenocompound metabolism_Homo sapiens_hsa004500.41023930
110RNA degradation_Homo sapiens_hsa030180.40340468
111RNA polymerase_Homo sapiens_hsa030200.40016391
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.39509214
113Dorso-ventral axis formation_Homo sapiens_hsa043200.38289560
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36792729
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35302025
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35078848
117Phagosome_Homo sapiens_hsa041450.34243262
118ABC transporters_Homo sapiens_hsa020100.34075488
119Renal cell carcinoma_Homo sapiens_hsa052110.33002657
120mRNA surveillance pathway_Homo sapiens_hsa030150.32796442
121Caffeine metabolism_Homo sapiens_hsa002320.32684556
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32624428
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32002953
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31266266
125Nucleotide excision repair_Homo sapiens_hsa034200.30725904
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.29910466
127TGF-beta signaling pathway_Homo sapiens_hsa043500.29559410
128Lysine degradation_Homo sapiens_hsa003100.29037373
129Pathways in cancer_Homo sapiens_hsa052000.28937417
130Prion diseases_Homo sapiens_hsa050200.28891398
131African trypanosomiasis_Homo sapiens_hsa051430.28178198
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28109981

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