POU4F2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority of breast cancers, resulting in accelerated tumor growth. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1metanephric mesenchyme development (GO:0072075)8.65205287
2generation of neurons (GO:0048699)8.59799691
3kidney mesenchyme development (GO:0072074)7.83255971
4cell migration in hindbrain (GO:0021535)7.17517388
5myoblast migration (GO:0051451)6.52804827
6neuron cell-cell adhesion (GO:0007158)6.25470862
7peripheral nervous system neuron development (GO:0048935)6.23777665
8detection of temperature stimulus (GO:0016048)6.19726756
9positive regulation of gastrulation (GO:2000543)6.11497063
10negative regulation of microtubule polymerization (GO:0031115)5.89483931
11segment specification (GO:0007379)5.86737854
12cranial nerve morphogenesis (GO:0021602)5.53521492
13enteric nervous system development (GO:0048484)5.47492018
14exogenous drug catabolic process (GO:0042738)5.31449945
15cranial nerve development (GO:0021545)5.25395233
16proximal/distal pattern formation (GO:0009954)5.22426823
17limb development (GO:0060173)5.11591022
18appendage development (GO:0048736)5.11591022
19regulation of respiratory gaseous exchange by neurological system process (GO:0002087)5.06103075
20neuron fate specification (GO:0048665)5.04747257
21negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.75396363
22detection of temperature stimulus involved in sensory perception (GO:0050961)4.71604989
23detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.71604989
24planar cell polarity pathway involved in neural tube closure (GO:0090179)4.65083366
25head development (GO:0060322)4.63234824
26arginine catabolic process (GO:0006527)4.59884523
27positive regulation of embryonic development (GO:0040019)4.55216786
28negative regulation of calcium ion transport into cytosol (GO:0010523)4.52250107
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.50801853
30negative regulation of catenin import into nucleus (GO:0035414)4.46551262
31positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)4.34865573
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.32280680
33energy coupled proton transport, down electrochemical gradient (GO:0015985)4.31860976
34ATP synthesis coupled proton transport (GO:0015986)4.31860976
35regulation of secondary heart field cardioblast proliferation (GO:0003266)4.29243788
36regulation of cardioblast proliferation (GO:0003264)4.29243788
37sympathetic nervous system development (GO:0048485)4.27650085
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.25129964
39negative regulation of striated muscle cell apoptotic process (GO:0010664)4.21757881
40neuron projection extension involved in neuron projection guidance (GO:1902284)4.20582820
41axon extension involved in axon guidance (GO:0048846)4.20582820
42synaptic transmission, cholinergic (GO:0007271)4.19895577
43nephron tubule formation (GO:0072079)4.16928169
44regulation of respiratory gaseous exchange (GO:0043576)4.09328411
45innervation (GO:0060384)4.06515294
46regulation of respiratory system process (GO:0044065)4.06028686
47G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.02864110
48drug catabolic process (GO:0042737)3.99835927
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.98790236
50cell differentiation involved in metanephros development (GO:0072202)3.97291967
51organ induction (GO:0001759)3.96172024
52regulation of cardioblast differentiation (GO:0051890)3.95341726
53positive regulation of mesonephros development (GO:0061213)3.90473057
54positive regulation of transcription regulatory region DNA binding (GO:2000679)3.90008965
55neurogenesis (GO:0022008)3.89750562
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.87426488
57presynaptic membrane organization (GO:0097090)3.85628669
58central nervous system myelination (GO:0022010)3.85239591
59axon ensheathment in central nervous system (GO:0032291)3.85239591
60axonal fasciculation (GO:0007413)3.80425220
61regulation of short-term neuronal synaptic plasticity (GO:0048172)3.76001138
62embryonic retina morphogenesis in camera-type eye (GO:0060059)3.74598792
63positive regulation of cell size (GO:0045793)3.63270020
64regulation of synapse assembly (GO:0051963)3.63149966
65positive regulation of dendritic spine morphogenesis (GO:0061003)3.63102928
66urogenital system development (GO:0001655)3.60698583
67somite development (GO:0061053)3.60412096
68nerve development (GO:0021675)3.59892117
69* retinal ganglion cell axon guidance (GO:0031290)3.59224993
70embryonic skeletal joint morphogenesis (GO:0060272)3.58742000
71cochlea morphogenesis (GO:0090103)3.57809768
72suckling behavior (GO:0001967)3.56784474
73glomerulus development (GO:0032835)3.54289950
74ganglion development (GO:0061548)3.53567081
75muscle cell proliferation (GO:0033002)3.52224429
76regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.52059191
77regulation of transforming growth factor beta2 production (GO:0032909)3.51958869
78proline transport (GO:0015824)3.50881731
79regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.50608459
80establishment of integrated proviral latency (GO:0075713)3.49798634
81pharyngeal system development (GO:0060037)3.48645420
82positive regulation of vesicle fusion (GO:0031340)3.46093934
83regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.43959543
84synaptic vesicle maturation (GO:0016188)3.43501775
85coronary vasculature morphogenesis (GO:0060977)3.43211610
86sequestering of actin monomers (GO:0042989)3.42024954
87forelimb morphogenesis (GO:0035136)3.40292648
88negative regulation of axon guidance (GO:1902668)3.37856751
89regulation of heart morphogenesis (GO:2000826)3.37043869
90neuronal action potential propagation (GO:0019227)3.35131592
91protein neddylation (GO:0045116)3.34831028
92negative regulation of dendrite morphogenesis (GO:0050774)3.34097763
93chaperone-mediated protein transport (GO:0072321)3.30972028
94hindlimb morphogenesis (GO:0035137)3.29501374
95cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.27791320
96neuronal ion channel clustering (GO:0045161)3.26925524
97regulation of organ formation (GO:0003156)3.26797145
98substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.23298307
99substrate-independent telencephalic tangential migration (GO:0021826)3.23298307
100nephron tubule morphogenesis (GO:0072078)3.22786781
101nephron epithelium morphogenesis (GO:0072088)3.22786781
102respiratory electron transport chain (GO:0022904)3.21499631
103mesenchyme morphogenesis (GO:0072132)3.20974037
104regulation of cardiac muscle cell apoptotic process (GO:0010665)3.20764928
105negative regulation of axon extension involved in axon guidance (GO:0048843)3.19914544
106membrane budding (GO:0006900)3.18967638
107regulation of striated muscle cell apoptotic process (GO:0010662)3.18846118
108layer formation in cerebral cortex (GO:0021819)3.17884214
109regulation of mesonephros development (GO:0061217)3.17578553
110glomerular filtration (GO:0003094)3.15001597
111electron transport chain (GO:0022900)3.14693792
112embryonic digestive tract development (GO:0048566)3.14543392
113cell-cell signaling involved in cell fate commitment (GO:0045168)3.14344783
114aorta morphogenesis (GO:0035909)3.13615324
115positive regulation of odontogenesis (GO:0042482)3.10915818
116cardiac muscle cell proliferation (GO:0060038)3.07839857
117embryonic body morphogenesis (GO:0010172)3.06053144
118negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.05508458
119pyrimidine nucleobase catabolic process (GO:0006208)3.05222837
120cerebellar Purkinje cell differentiation (GO:0021702)3.04579474
121developmental induction (GO:0031128)3.04059456
122regulation of microtubule polymerization (GO:0031113)3.02499435
123regulation of synaptic vesicle exocytosis (GO:2000300)3.01435886
124artery smooth muscle contraction (GO:0014824)2.99851179
125negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.99703402
126central nervous system projection neuron axonogenesis (GO:0021952)2.99175961
127neuromuscular synaptic transmission (GO:0007274)2.99054354
128protein polyglutamylation (GO:0018095)2.95823755
129nucleobase catabolic process (GO:0046113)2.95329289
130Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.94712350
131positive regulation of guanylate cyclase activity (GO:0031284)2.93973442
132membrane depolarization during action potential (GO:0086010)2.93966358
133positive regulation of glomerulus development (GO:0090193)2.92625701
134retina layer formation (GO:0010842)2.92519392
135neurotransmitter biosynthetic process (GO:0042136)2.91494874
136negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.91380300
137potassium ion export (GO:0071435)2.90045763
138neurofilament cytoskeleton organization (GO:0060052)2.89572018
139neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.89513538
140regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.88872200
141glandular epithelial cell development (GO:0002068)2.88751292
142thyroid gland development (GO:0030878)2.88045807
143ectodermal placode formation (GO:0060788)2.87810360
144positive regulation of T cell apoptotic process (GO:0070234)2.87637665
145apical protein localization (GO:0045176)2.86603741
146positive regulation of synapse assembly (GO:0051965)2.84507613
147embryonic forelimb morphogenesis (GO:0035115)2.84395384
148negative regulation of cell fate commitment (GO:0010454)2.84020667
149embryonic skeletal system morphogenesis (GO:0048704)2.83756068
150retinal cone cell development (GO:0046549)2.82957270
151positive regulation of kidney development (GO:0090184)2.82404302
152negative regulation of embryonic development (GO:0045992)2.82067114
153dopamine biosynthetic process (GO:0042416)2.79875653
154calcium-mediated signaling using intracellular calcium source (GO:0035584)2.79696572
155negative regulation of kidney development (GO:0090185)2.79152795
156regulation of synapse organization (GO:0050807)2.78552446
157regulation of establishment of planar polarity (GO:0090175)2.77800323
158axon cargo transport (GO:0008088)2.77334622
159microtubule depolymerization (GO:0007019)2.76912692
160neuron recognition (GO:0008038)2.76839677
161dendritic spine morphogenesis (GO:0060997)2.76354093
162pattern specification involved in kidney development (GO:0061004)2.76245536
163synaptic vesicle exocytosis (GO:0016079)2.75728581
164arginine metabolic process (GO:0006525)2.75713241
165positive regulation of synaptic transmission, GABAergic (GO:0032230)2.75286523
166microtubule bundle formation (GO:0001578)2.75066694
167negative regulation of Ras GTPase activity (GO:0034261)2.74984361
168muscle cell migration (GO:0014812)2.74402632
169sensory perception of pain (GO:0019233)2.74402094
170vocalization behavior (GO:0071625)2.71989303
171tongue development (GO:0043586)2.71873873
172protein localization to synapse (GO:0035418)2.70309860
173negative regulation of heart rate (GO:0010459)2.69844829
174neuronal action potential (GO:0019228)2.69749573
175response to gravity (GO:0009629)2.66127634
176viral transcription (GO:0019083)2.65676652
177establishment of mitochondrion localization (GO:0051654)2.64810648
178cell communication involved in cardiac conduction (GO:0086065)2.64747955
179regulation of guanylate cyclase activity (GO:0031282)2.62978113
180cellular response to prostaglandin stimulus (GO:0071379)2.61743281
181establishment of viral latency (GO:0019043)2.61694429
182membrane assembly (GO:0071709)2.61348706
183eating behavior (GO:0042755)2.60520436
184positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.59701110
185regulation of dopamine secretion (GO:0014059)2.59088745
186glutamate secretion (GO:0014047)2.58382557
187regulation of protein heterodimerization activity (GO:0043497)2.55941648
188positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.54704562
189establishment of protein localization to mitochondrial membrane (GO:0090151)2.53240020
190positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.53011397
191response to water (GO:0009415)2.51033272
192translational termination (GO:0006415)2.51028168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.79407320
2CBX2_27304074_Chip-Seq_ESCs_Mouse3.76253216
3EZH2_22144423_ChIP-Seq_EOC_Human3.64518190
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.17440621
5* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.94529700
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65991907
7* EZH2_27304074_Chip-Seq_ESCs_Mouse2.64952087
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.62673902
9ZNF263_19887448_ChIP-Seq_K562_Human2.59778776
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.59481554
11* REST_21632747_ChIP-Seq_MESCs_Mouse2.59104818
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.55022985
13* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.48545554
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47065424
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47065424
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.45716592
17* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.44340280
18* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43292963
19FUS_26573619_Chip-Seq_HEK293_Human2.36311364
20* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.31655024
21IGF1R_20145208_ChIP-Seq_DFB_Human2.29814889
22ERG_21242973_ChIP-ChIP_JURKAT_Human2.26516219
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.24533743
24* REST_18959480_ChIP-ChIP_MESCs_Mouse2.23900441
25* EZH2_27294783_Chip-Seq_ESCs_Mouse2.23034793
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21157886
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19117696
28* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16905503
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14526325
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12827401
31ZNF274_21170338_ChIP-Seq_K562_Hela2.11761279
32ZFP281_18757296_ChIP-ChIP_E14_Mouse2.11281826
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.05988983
34TP63_19390658_ChIP-ChIP_HaCaT_Human2.04048913
35* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.03640654
36SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.01419355
37ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.96785202
38* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.96513777
39* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95921838
40* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.93477494
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.91677869
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.90890725
43* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89567403
44* RNF2_27304074_Chip-Seq_ESCs_Mouse1.87485464
45SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.86003753
46* TP53_20018659_ChIP-ChIP_R1E_Mouse1.84619989
47* RING1B_27294783_Chip-Seq_NPCs_Mouse1.80974556
48* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80203862
49* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78092747
50RNF2_27304074_Chip-Seq_NSC_Mouse1.75817617
51RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.74279585
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72950962
53KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.71506349
54* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69564022
55NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.67436212
56NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.66217913
57* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63939978
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59686070
59* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58804038
60* EED_16625203_ChIP-ChIP_MESCs_Mouse1.58343183
61P300_19829295_ChIP-Seq_ESCs_Human1.58317296
62* RING1B_27294783_Chip-Seq_ESCs_Mouse1.53680841
63OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.53597597
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.53426368
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52726005
66HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51902211
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.49933227
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43942053
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43942053
70* CTCF_27219007_Chip-Seq_Bcells_Human1.43298245
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42755605
72NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.41541034
73SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.41145173
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40329648
75GBX2_23144817_ChIP-Seq_PC3_Human1.38422540
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36806358
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.36326492
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35603017
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.35448308
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.35172566
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.35172566
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.35172566
83KDM2B_26808549_Chip-Seq_K562_Human1.34092187
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32894677
85DROSHA_22980978_ChIP-Seq_HELA_Human1.32878429
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32659552
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30376508
88MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30076886
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28110372
90TAF15_26573619_Chip-Seq_HEK293_Human1.27879004
91MYC_18555785_ChIP-Seq_MESCs_Mouse1.27465412
92ISL1_27105846_Chip-Seq_CPCs_Mouse1.26992668
93SMAD4_21799915_ChIP-Seq_A2780_Human1.26763487
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26417764
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.21525065
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21185062
97NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.21000644
98SOX9_26525672_Chip-Seq_HEART_Mouse1.20516819
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20329333
100CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.16881312
101AR_25329375_ChIP-Seq_VCAP_Human1.16168918
102TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15561953
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14703263
104TET1_21490601_ChIP-Seq_MESCs_Mouse1.14432148
105PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.14163391
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13772955
107* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12975622
108SOX2_16153702_ChIP-ChIP_HESCs_Human1.11987474
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09541520
110CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08456810
111* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08081757
112POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.07666934
113VDR_22108803_ChIP-Seq_LS180_Human1.07600098
114ELK4_26923725_Chip-Seq_MESODERM_Mouse1.06986493
115EWS_26573619_Chip-Seq_HEK293_Human1.05142460
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05096248
117IRF1_19129219_ChIP-ChIP_H3396_Human1.03945576
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03117182
119POU5F1_16518401_ChIP-PET_MESCs_Mouse1.02029457
120TBL1_22424771_ChIP-Seq_293T_Human1.00970105
121KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00850472
122SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00631903
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99681031
124TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.99439378
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98967514
126* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98847154
127* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97869777
128FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97220830
129* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96128373
130OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95631767
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95294862
132AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94036125
133AHR_22903824_ChIP-Seq_MCF-7_Human0.93924487
134SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93793531
135TAL1_26923725_Chip-Seq_HPCs_Mouse0.93305718
136WT1_19549856_ChIP-ChIP_CCG9911_Human0.93275209
137TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93268872
138SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93058017
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92238505
140HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92055767
141SOX2_21211035_ChIP-Seq_LN229_Gbm0.91952224
142YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91807516
143TP63_17297297_ChIP-ChIP_HaCaT_Human0.91393771
144CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91271990
145* RUNX2_22187159_ChIP-Seq_PCA_Human0.90872042
146SA1_27219007_Chip-Seq_ERYTHROID_Human0.89641839
147POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89444942
148EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88265543
149PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87254865
150* STAT3_23295773_ChIP-Seq_U87_Human0.86771694
151TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86743326
152EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82701862
153TBX3_20139965_ChIP-Seq_ESCs_Mouse0.82424731
154TBX3_20139965_ChIP-Seq_MESCs_Mouse0.82407067
155CBP_20019798_ChIP-Seq_JUKART_Human0.82031725

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception3.90023413
2MP0010030_abnormal_orbit_morphology3.85544087
3MP0004858_abnormal_nervous_system3.82294391
4MP0002653_abnormal_ependyma_morphology3.73821608
5MP0002735_abnormal_chemical_nociception3.72180187
6MP0005423_abnormal_somatic_nervous3.39723036
7MP0002736_abnormal_nociception_after3.36675989
8MP0003880_abnormal_central_pattern3.32014005
9MP0004270_analgesia3.12296403
10MP0002733_abnormal_thermal_nociception3.09150591
11MP0006276_abnormal_autonomic_nervous3.06364687
12MP0002751_abnormal_autonomic_nervous3.04758306
13MP0004859_abnormal_synaptic_plasticity2.97896334
14MP0003878_abnormal_ear_physiology2.87912200
15MP0005377_hearing/vestibular/ear_phenot2.87912200
16MP0002734_abnormal_mechanical_nocicepti2.82955961
17* MP0002184_abnormal_innervation2.74144878
18MP0001970_abnormal_pain_threshold2.68126911
19MP0001299_abnormal_eye_distance/2.65966265
20MP0009379_abnormal_foot_pigmentation2.62193554
21MP0005503_abnormal_tendon_morphology2.58163835
22MP0002638_abnormal_pupillary_reflex2.52455476
23MP0005248_abnormal_Harderian_gland2.51093139
24MP0005645_abnormal_hypothalamus_physiol2.50723589
25MP0001346_abnormal_lacrimal_gland2.45926027
26MP0004133_heterotaxia2.42271494
27MP0002932_abnormal_joint_morphology2.28145295
28MP0003635_abnormal_synaptic_transmissio2.20942997
29MP0002102_abnormal_ear_morphology2.13385068
30* MP0000778_abnormal_nervous_system2.10799975
31MP0003385_abnormal_body_wall1.96049956
32MP0002233_abnormal_nose_morphology1.95399650
33MP0000955_abnormal_spinal_cord1.90593323
34MP0003938_abnormal_ear_development1.88963683
35MP0006292_abnormal_olfactory_placode1.87588659
36MP0003755_abnormal_palate_morphology1.86957376
37MP0000733_abnormal_muscle_development1.84708067
38MP0001440_abnormal_grooming_behavior1.83730086
39MP0003115_abnormal_respiratory_system1.79513684
40MP0000613_abnormal_salivary_gland1.75757913
41MP0000538_abnormal_urinary_bladder1.75085126
42MP0001529_abnormal_vocalization1.71785844
43MP0003890_abnormal_embryonic-extraembry1.69814211
44* MP0001502_abnormal_circadian_rhythm1.68573386
45MP0001879_abnormal_lymphatic_vessel1.67201366
46MP0002272_abnormal_nervous_system1.63568629
47MP0002116_abnormal_craniofacial_bone1.63502440
48MP0001177_atelectasis1.63169715
49* MP0006072_abnormal_retinal_apoptosis1.61116802
50MP0002063_abnormal_learning/memory/cond1.55749802
51MP0009053_abnormal_anal_canal1.55173886
52MP0000026_abnormal_inner_ear1.53803895
53MP0004233_abnormal_muscle_weight1.53293353
54* MP0004811_abnormal_neuron_physiology1.52924266
55MP0009745_abnormal_behavioral_response1.48623262
56MP0003122_maternal_imprinting1.45158241
57MP0000631_abnormal_neuroendocrine_gland1.43922081
58MP0000534_abnormal_ureter_morphology1.43011495
59* MP0002882_abnormal_neuron_morphology1.41498064
60MP0003646_muscle_fatigue1.41079665
61MP0002572_abnormal_emotion/affect_behav1.40695192
62MP0010386_abnormal_urinary_bladder1.39050998
63MP0002067_abnormal_sensory_capabilities1.39048144
64MP0009250_abnormal_appendicular_skeleto1.38105274
65MP0004883_abnormal_blood_vessel1.37612490
66MP0005499_abnormal_olfactory_system1.34047660
67MP0005394_taste/olfaction_phenotype1.34047660
68MP0003136_yellow_coat_color1.32262641
69* MP0002752_abnormal_somatic_nervous1.31734665
70MP0002277_abnormal_respiratory_mucosa1.31410186
71MP0002822_catalepsy1.28185710
72MP0002064_seizures1.27541919
73MP0003935_abnormal_craniofacial_develop1.27306957
74MP0008789_abnormal_olfactory_epithelium1.24063023
75MP0005508_abnormal_skeleton_morphology1.23121324
76MP0000428_abnormal_craniofacial_morphol1.22324776
77MP0002114_abnormal_axial_skeleton1.22172377
78MP0002396_abnormal_hematopoietic_system1.21965907
79MP0003942_abnormal_urinary_system1.19752320
80MP0002109_abnormal_limb_morphology1.18201374
81* MP0005391_vision/eye_phenotype1.18166269
82MP0002127_abnormal_cardiovascular_syste1.17883665
83MP0009046_muscle_twitch1.17812880
84MP0001501_abnormal_sleep_pattern1.17571386
85MP0003123_paternal_imprinting1.17521460
86MP0001984_abnormal_olfaction1.15175837
87MP0005187_abnormal_penis_morphology1.14900680
88MP0001486_abnormal_startle_reflex1.14648615
89MP0002697_abnormal_eye_size1.13372951
90MP0003567_abnormal_fetal_cardiomyocyte1.12029807
91MP0000516_abnormal_urinary_system1.11763204
92MP0005367_renal/urinary_system_phenotyp1.11763204
93* MP0001963_abnormal_hearing_physiology1.10993961
94MP0001188_hyperpigmentation1.10213829
95MP0000566_synostosis1.09230288
96MP0000762_abnormal_tongue_morphology1.07430585
97MP0001986_abnormal_taste_sensitivity1.05229188
98MP0003787_abnormal_imprinting1.04667112
99MP0002249_abnormal_larynx_morphology1.03354782
100* MP0004742_abnormal_vestibular_system1.02999194
101MP0002557_abnormal_social/conspecific_i1.00912951
102MP0002160_abnormal_reproductive_system1.00491405
103MP0001664_abnormal_digestion1.00463912
104MP0003119_abnormal_digestive_system0.98943043
105MP0005083_abnormal_biliary_tract0.98814298
106* MP0005551_abnormal_eye_electrophysiolog0.96700019
107MP0001348_abnormal_lacrimal_gland0.96491630
108MP0002066_abnormal_motor_capabilities/c0.92276505
109MP0001943_abnormal_respiration0.92208549
110* MP0002152_abnormal_brain_morphology0.90944684
111MP0004134_abnormal_chest_morphology0.90623206
112MP0002111_abnormal_tail_morphology0.89511057
113MP0000751_myopathy0.87020736
114MP0003315_abnormal_perineum_morphology0.86910434
115MP0001293_anophthalmia0.86663659
116MP0002081_perinatal_lethality0.86007905
117MP0003861_abnormal_nervous_system0.84442807
118MP0000537_abnormal_urethra_morphology0.84127969
119MP0002089_abnormal_postnatal_growth/wei0.83889709
120MP0002177_abnormal_outer_ear0.82789387
121MP0001270_distended_abdomen0.81892368
122MP0004885_abnormal_endolymph0.80824035
123MP0000432_abnormal_head_morphology0.79029441
124MP0002085_abnormal_embryonic_tissue0.78655315
125* MP0005253_abnormal_eye_physiology0.77514521
126* MP0001286_abnormal_eye_development0.77283654
127MP0003959_abnormal_lean_body0.75882393
128MP0008961_abnormal_basal_metabolism0.74957119
129MP0001340_abnormal_eyelid_morphology0.74782239
130MP0003718_maternal_effect0.74592245
131MP0002909_abnormal_adrenal_gland0.74075283
132MP0000049_abnormal_middle_ear0.73397761
133MP0003937_abnormal_limbs/digits/tail_de0.73221406
134MP0001485_abnormal_pinna_reflex0.72068694
135MP0002938_white_spotting0.71921433
136* MP0005197_abnormal_uvea_morphology0.70830500
137MP0002069_abnormal_eating/drinking_beha0.70693768
138MP0006138_congestive_heart_failure0.70478813
139MP0004084_abnormal_cardiac_muscle0.70338926
140MP0003283_abnormal_digestive_organ0.69952726
141MP0008874_decreased_physiological_sensi0.68857596
142MP0002234_abnormal_pharynx_morphology0.68490574
143MP0008775_abnormal_heart_ventricle0.67515317
144MP0003868_abnormal_feces_composition0.66383433
145* MP0005195_abnormal_posterior_eye0.65808194
146MP0003879_abnormal_hair_cell0.64828599
147MP0008932_abnormal_embryonic_tissue0.63714658
148MP0008872_abnormal_physiological_respon0.63607247
149MP0005623_abnormal_meninges_morphology0.62767079
150MP0003137_abnormal_impulse_conducting0.61977966
151MP0008877_abnormal_DNA_methylation0.60636083
152MP0003121_genomic_imprinting0.60065403
153MP0004085_abnormal_heartbeat0.59088316
154MP0000681_abnormal_thyroid_gland0.58955910
155* MP0003634_abnormal_glial_cell0.58894812

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.65863469
2Pheochromocytoma (HP:0002666)6.02705050
3Calcaneovalgus deformity (HP:0001848)5.60624550
4Lip pit (HP:0100267)5.27808108
5Neuroendocrine neoplasm (HP:0100634)5.21772381
6Deformed tarsal bones (HP:0008119)4.86574439
7Hypercortisolism (HP:0001578)4.82330293
8Failure to thrive in infancy (HP:0001531)4.51910878
9Abnormal hemoglobin (HP:0011902)4.10890581
10Termporal pattern (HP:0011008)4.05630030
11Insidious onset (HP:0003587)4.05630030
12Myotonia (HP:0002486)3.98178433
13Abnormality of the 4th metacarpal (HP:0010012)3.92738548
14High anterior hairline (HP:0009890)3.90872388
15Abnormality of the calcaneus (HP:0008364)3.89824883
16Midline defect of the nose (HP:0004122)3.73919843
17Ulnar claw (HP:0001178)3.62418344
18Amblyopia (HP:0000646)3.61380091
19Neoplasm of the peripheral nervous system (HP:0100007)3.56286682
20Agitation (HP:0000713)3.55083374
21Hypoventilation (HP:0002791)3.53911964
22Hemorrhage of the eye (HP:0011885)3.51248670
23Facial shape deformation (HP:0011334)3.40250305
24Potter facies (HP:0002009)3.40250305
25Hepatoblastoma (HP:0002884)3.29832459
26Postural tremor (HP:0002174)3.15690988
27Progressive cerebellar ataxia (HP:0002073)3.13822587
28Abnormality of the parathyroid morphology (HP:0011766)3.06531027
29Short 4th metacarpal (HP:0010044)3.04110295
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.04110295
31Hyperparathyroidism (HP:0000843)2.98776204
32Arterial tortuosity (HP:0005116)2.97475350
33Abnormality of calcium-phosphate metabolism (HP:0100530)2.87952601
34Morphological abnormality of the middle ear (HP:0008609)2.87883077
35Neuroblastic tumors (HP:0004376)2.87341709
36Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.87341709
37Neuroblastoma (HP:0003006)2.87341709
38Primitive neuroectodermal tumor (HP:0030065)2.87341709
39Abnormality of the vocal cords (HP:0008777)2.84622272
40Abnormal pancreas size (HP:0012094)2.83382835
41Action tremor (HP:0002345)2.80429309
42Testicular neoplasm (HP:0010788)2.77471768
43Exotropia (HP:0000577)2.76434166
44Cerebral hemorrhage (HP:0001342)2.75723566
45Abnormality of the corticospinal tract (HP:0002492)2.72878617
46Acute necrotizing encephalopathy (HP:0006965)2.70649356
47Abnormality of the anterior chamber (HP:0000593)2.70417654
48Retinal dysplasia (HP:0007973)2.68472594
49Limb dystonia (HP:0002451)2.68469729
50Hypoplasia of the brainstem (HP:0002365)2.67988396
51Aplasia/Hypoplasia of the brainstem (HP:0007362)2.67988396
52Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.66741145
53Bifid tongue (HP:0010297)2.64763188
54Periauricular skin pits (HP:0100277)2.63842666
55Preauricular pit (HP:0004467)2.63842666
56Hyperthyroidism (HP:0000836)2.62585488
57Premature rupture of membranes (HP:0001788)2.52797688
58Anophthalmia (HP:0000528)2.51097083
59Buphthalmos (HP:0000557)2.49817768
60Cortical dysplasia (HP:0002539)2.49117070
61Vascular tortuosity (HP:0004948)2.48981889
62Foot dorsiflexor weakness (HP:0009027)2.48224340
63Hypoplastic ischia (HP:0003175)2.47747111
64Overlapping toe (HP:0001845)2.47419154
65Febrile seizures (HP:0002373)2.45182943
66Aortic dissection (HP:0002647)2.43790385
67Abnormality of the labia minora (HP:0012880)2.42886122
68Visual hallucinations (HP:0002367)2.42804860
69Partial agenesis of the corpus callosum (HP:0001338)2.42597429
70Morphological abnormality of the pyramidal tract (HP:0002062)2.41361829
71Progressive macrocephaly (HP:0004481)2.39842647
72Abnormality of the pubic bones (HP:0003172)2.37450442
73Mitral valve prolapse (HP:0001634)2.36809061
74Focal seizures (HP:0007359)2.36742913
75Atrioventricular block (HP:0001678)2.34356385
76Esotropia (HP:0000565)2.32833295
77Ankle clonus (HP:0011448)2.29005379
78Abnormality of the ischium (HP:0003174)2.28693873
79Absent eyebrow (HP:0002223)2.23495153
80Generalized hypotonia (HP:0001290)2.23396785
81Urinary urgency (HP:0000012)2.22581298
82Enlarged penis (HP:0000040)2.22375431
83Restlessness (HP:0000711)2.21826665
84Bicornuate uterus (HP:0000813)2.20514480
85Atrioventricular canal defect (HP:0006695)2.19878299
86Abnormality of the foot musculature (HP:0001436)2.19691042
87Infantile muscular hypotonia (HP:0008947)2.19566937
88Vitreoretinal degeneration (HP:0000655)2.17816923
89Patellar aplasia (HP:0006443)2.16973631
90Retinal detachment (HP:0000541)2.16875472
91Focal motor seizures (HP:0011153)2.14067651
92Aplasia/Hypoplasia of the lens (HP:0008063)2.13825310
93Hammertoe (HP:0001765)2.11504784
94Abnormal mitochondria in muscle tissue (HP:0008316)2.11066753
95Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.11031583
96Cutaneous finger syndactyly (HP:0010554)2.10833030
97Poor suck (HP:0002033)2.10460615
98Optic nerve hypoplasia (HP:0000609)2.09568886
99Thyroid carcinoma (HP:0002890)2.09322583
100Impaired pain sensation (HP:0007328)2.09177604
101Abnormality of pain sensation (HP:0010832)2.09177604
102Iris coloboma (HP:0000612)2.09012962
103Type II lissencephaly (HP:0007260)2.06974887
104Intestinal polyposis (HP:0200008)2.05435158
105Bell-shaped thorax (HP:0001591)2.03734282
106Omphalocele (HP:0001539)2.03725527
107Acute encephalopathy (HP:0006846)2.03419696
108Bilateral microphthalmos (HP:0007633)2.03164626
109Atonic seizures (HP:0010819)2.02938809
110Skin pits (HP:0100276)2.02853183
111Megalencephaly (HP:0001355)2.00098016
112Adrenal overactivity (HP:0002717)2.00054257
113Overgrowth (HP:0001548)1.99621807
114Narrow nasal bridge (HP:0000446)1.97328604
115Abnormality of the lower motor neuron (HP:0002366)1.95695436
116Intestinal atresia (HP:0011100)1.94342037
117Abnormality of midbrain morphology (HP:0002418)1.92919149
118Molar tooth sign on MRI (HP:0002419)1.92919149
119Congenital diaphragmatic hernia (HP:0000776)1.92087182
120Sensory axonal neuropathy (HP:0003390)1.91804847
121Sclerocornea (HP:0000647)1.91339506
122Shawl scrotum (HP:0000049)1.91333435
123Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90414141
124Keratoconus (HP:0000563)1.89679023
125Increased corneal curvature (HP:0100692)1.89679023
126Mitochondrial inheritance (HP:0001427)1.87768934
127Submucous cleft hard palate (HP:0000176)1.86804840
128Intestinal polyp (HP:0005266)1.86554018
129Aplasia/Hypoplasia of the patella (HP:0006498)1.85647745
130Anencephaly (HP:0002323)1.85010015
131Impaired vibration sensation in the lower limbs (HP:0002166)1.84835720
132Spastic gait (HP:0002064)1.84671874
133Occipital encephalocele (HP:0002085)1.84364360
134Bony spicule pigmentary retinopathy (HP:0007737)1.83993776
135Deep palmar crease (HP:0006191)1.82747794
136Preaxial hand polydactyly (HP:0001177)1.82701632
137Truncal ataxia (HP:0002078)1.82645871
138Esophageal atresia (HP:0002032)1.81814563
139Neuroectodermal neoplasm (HP:0030061)1.80901297
140Neuroepithelial neoplasm (HP:0030063)1.80901297
141Nervous tissue neoplasm (HP:0030060)1.80901297
142Cubitus valgus (HP:0002967)1.80825928
143Cutaneous syndactyly (HP:0012725)1.80305641
144Congenital glaucoma (HP:0001087)1.80208772
145Prolonged QT interval (HP:0001657)1.79649737
146Specific learning disability (HP:0001328)1.79494568
147Highly arched eyebrow (HP:0002553)1.79243016
148Sacral dimple (HP:0000960)1.78274310
149Abnormality of the intervertebral disk (HP:0005108)1.78094973
150Hypercalcemia (HP:0003072)1.77702503
151Urinary bladder sphincter dysfunction (HP:0002839)1.77536483
152Postaxial foot polydactyly (HP:0001830)1.77390559
153Pendular nystagmus (HP:0012043)1.77344608
154Genu recurvatum (HP:0002816)1.77308695
155Goiter (HP:0000853)1.77114293
156Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75458409
157Adenoma sebaceum (HP:0009720)1.75239270
158Angiofibromas (HP:0010615)1.75239270
159Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74901898
160Atresia of the external auditory canal (HP:0000413)1.74891362
161Severe visual impairment (HP:0001141)1.73912731
162Neonatal respiratory distress (HP:0002643)1.73828532
163Sprengel anomaly (HP:0000912)1.72924551
164Chronic hepatic failure (HP:0100626)1.72729991
165Genital tract atresia (HP:0001827)1.72691504
166Hypoplastic left heart (HP:0004383)1.72288879
167Bladder diverticulum (HP:0000015)1.72208549
168Generalized tonic-clonic seizures (HP:0002069)1.72099856
169Neoplasm of the thyroid gland (HP:0100031)1.71761133
170Neoplasm of the adrenal cortex (HP:0100641)1.71243944
171Spondylolisthesis (HP:0003302)1.70930454
172Hydroureter (HP:0000072)1.70807648
173Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70148783
174Abnormality of the aortic arch (HP:0012303)1.69116318
175Short 5th finger (HP:0009237)1.68779751
176Cerebral edema (HP:0002181)1.68743011
177Epiphyseal dysplasia (HP:0002656)1.68585748
178Absence seizures (HP:0002121)1.68120325
179Broad nasal tip (HP:0000455)1.67412976
180Severe Myopia (HP:0011003)1.67128072
181Nephronophthisis (HP:0000090)1.65694414
182Lissencephaly (HP:0001339)1.64021361
183Preauricular skin tag (HP:0000384)1.63444207
184Adrenal hypoplasia (HP:0000835)1.63418018
185Renovascular hypertension (HP:0100817)1.63343361
186Non-midline cleft lip (HP:0100335)1.62236468
187Renal hypoplasia (HP:0000089)1.61087544
188Oligodactyly (hands) (HP:0001180)1.60691584
189Skin tags (HP:0010609)1.60277101
190Chorioretinal coloboma (HP:0000567)1.59595696
191Multicystic kidney dysplasia (HP:0000003)1.59154935
192Short middle phalanx of the 5th finger (HP:0004220)1.59027771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK24.62087299
2MAP3K94.18525980
3GRK54.07859945
4MKNK13.34375295
5ERBB33.11870662
6LATS13.03492076
7ALK3.03435682
8MARK12.98405610
9MAPK132.69122286
10ARAF2.56283337
11UHMK12.44430739
12NEK12.40189365
13MAPKAPK32.34458356
14PIM22.32741094
15LIMK12.31625565
16LATS22.28710119
17MINK12.22918014
18NTRK32.22897903
19NME22.21347081
20NTRK11.92113536
21KSR21.87442473
22MAP3K21.84318659
23WNK11.84066983
24RET1.73133350
25EEF2K1.72665729
26PAK61.57135098
27DYRK21.56496462
28TRPM71.51290654
29STK38L1.50088509
30BRD41.45145917
31DAPK21.41404670
32TLK11.41217828
33MAP3K41.35099108
34SGK21.34990556
35EPHB21.33543449
36PHKG21.30124442
37PHKG11.30124442
38RPS6KA21.29768144
39CDK141.24119038
40PTK21.19826410
41NTRK21.17581817
42STK381.16764380
43NME11.13926082
44ZAK1.12317051
45PKN11.07543353
46DYRK31.05933337
47ADRBK21.05732473
48VRK11.04349053
49ADRBK11.03714096
50LMTK21.02945886
51STK31.02616390
52BCR1.02338260
53RPS6KC11.00528908
54RPS6KL11.00528908
55CDK181.00082242
56CDK150.99032032
57DAPK10.98749243
58HIPK20.98573010
59MAP2K20.96804341
60CAMK40.95729394
61CSNK1G30.93639495
62MET0.92104429
63CDK11A0.92072138
64SGK4940.91878437
65SGK2230.91878437
66AKT30.89797869
67SIK20.88276831
68MAP2K70.86134422
69RPS6KB20.85356440
70TSSK60.85234854
71STK40.85200216
72MAP3K60.84927580
73MAP4K20.84833864
74FLT30.84430297
75PLK40.83649626
76ERBB20.83473566
77MAP2K40.82197160
78MOS0.79747943
79MAP3K120.79389759
80CAMK1G0.79090047
81FER0.78806336
82CASK0.78788764
83CDK190.75169398
84NEK20.73233895
85CSNK1G20.73131455
86RPS6KA60.71355187
87CDK50.70263884
88ICK0.70060576
89CSNK1A1L0.69425548
90BMPR1B0.69262877
91MAP3K70.67843107
92MAPK150.67521806
93TESK10.66911905
94GRK10.65028473
95BRAF0.61967657
96IRAK10.61514338
97EPHA40.60262135
98CSNK1D0.59153884
99PASK0.58329559
100PNCK0.57687849
101KSR10.57359592
102PLK20.56986577
103MAP2K10.56552069
104DAPK30.55955048
105PDGFRA0.54463421
106PINK10.53884272
107MAPK120.51727615
108ERBB40.51137506
109MAPK40.50387067
110YES10.50278515
111PRKCG0.49306162
112SRPK10.49177957
113CDK30.48978938
114FGR0.48958958
115MARK20.48820630
116TAOK10.48807941
117PRKACA0.48503203
118CAMK10.48197905
119RAF10.47355496
120DYRK1B0.47253952
121CDK70.46161935
122CLK10.45362227
123CAMK2A0.44556048
124GSK3A0.44448110
125CSNK1E0.44345308
126PAK30.44149676
127DDR20.40526775
128TGFBR10.40253957
129PLK30.39501623
130PRKG10.39273170
131MAPKAPK50.39193385
132DYRK1A0.39138904
133CAMKK10.38746628
134TNIK0.38698989
135INSRR0.38612055
136AURKA0.38563710
137IRAK20.38396395
138PRKACG0.37116458
139PRKG20.35796951
140STK110.35603958
141MAP3K50.35472338
142MAPK90.35060053
143CSNK1G10.33195315
144CDK20.33007233
145PKN20.32491655
146SGK30.32343175
147STK390.32248061
148PRKCZ0.32230520
149PAK10.32077012
150PRKCB0.31982306
151MAPK80.31635554
152ATM0.29755719

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.08069245
2Basal cell carcinoma_Homo sapiens_hsa052173.95175828
3Parkinsons disease_Homo sapiens_hsa050123.90193419
4Alzheimers disease_Homo sapiens_hsa050103.10073241
5Synaptic vesicle cycle_Homo sapiens_hsa047212.97976973
6Huntingtons disease_Homo sapiens_hsa050162.86770429
7Cardiac muscle contraction_Homo sapiens_hsa042602.86752690
8Wnt signaling pathway_Homo sapiens_hsa043102.79139358
9Nicotine addiction_Homo sapiens_hsa050332.52654405
10Ribosome_Homo sapiens_hsa030102.44125774
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.32648151
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.21699051
13Phototransduction_Homo sapiens_hsa047442.11525255
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.03919026
15Arginine biosynthesis_Homo sapiens_hsa002202.02809527
16Circadian rhythm_Homo sapiens_hsa047101.80085334
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77562085
18Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.77395005
19Olfactory transduction_Homo sapiens_hsa047401.69282658
20Notch signaling pathway_Homo sapiens_hsa043301.66802004
21Thyroid cancer_Homo sapiens_hsa052161.66598331
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.66531089
23Taste transduction_Homo sapiens_hsa047421.57431112
24Circadian entrainment_Homo sapiens_hsa047131.50022370
25Cholinergic synapse_Homo sapiens_hsa047251.49645993
26Collecting duct acid secretion_Homo sapiens_hsa049661.48370096
27MicroRNAs in cancer_Homo sapiens_hsa052061.47422617
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.46476782
29Selenocompound metabolism_Homo sapiens_hsa004501.44867749
30Glutamatergic synapse_Homo sapiens_hsa047241.44647796
31Salivary secretion_Homo sapiens_hsa049701.42570782
32Long-term depression_Homo sapiens_hsa047301.40182531
33Steroid biosynthesis_Homo sapiens_hsa001001.37373898
34Gap junction_Homo sapiens_hsa045401.37010587
35Dopaminergic synapse_Homo sapiens_hsa047281.36290504
36Chronic myeloid leukemia_Homo sapiens_hsa052201.35413788
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29423598
38Non-small cell lung cancer_Homo sapiens_hsa052231.28713222
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28697116
40Long-term potentiation_Homo sapiens_hsa047201.27235403
41Insulin secretion_Homo sapiens_hsa049111.24629562
42Ether lipid metabolism_Homo sapiens_hsa005651.24530571
43TGF-beta signaling pathway_Homo sapiens_hsa043501.24003182
44Pathways in cancer_Homo sapiens_hsa052001.23211309
45GABAergic synapse_Homo sapiens_hsa047271.21634781
46Axon guidance_Homo sapiens_hsa043601.21058116
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18242431
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17845536
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13969648
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13079596
51Pancreatic cancer_Homo sapiens_hsa052121.12762228
52Alcoholism_Homo sapiens_hsa050341.10197216
53Central carbon metabolism in cancer_Homo sapiens_hsa052301.07360095
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04769215
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04716277
56Morphine addiction_Homo sapiens_hsa050320.99989975
57Proteasome_Homo sapiens_hsa030500.99471382
58Serotonergic synapse_Homo sapiens_hsa047260.98295824
59Amphetamine addiction_Homo sapiens_hsa050310.97491961
60Oocyte meiosis_Homo sapiens_hsa041140.96993436
61Basal transcription factors_Homo sapiens_hsa030220.94105442
62Butanoate metabolism_Homo sapiens_hsa006500.93562988
63Vibrio cholerae infection_Homo sapiens_hsa051100.93112622
64Dorso-ventral axis formation_Homo sapiens_hsa043200.91469355
65Cell cycle_Homo sapiens_hsa041100.90437336
66Lysine degradation_Homo sapiens_hsa003100.89428794
67mRNA surveillance pathway_Homo sapiens_hsa030150.89299190
68GnRH signaling pathway_Homo sapiens_hsa049120.88811684
69cAMP signaling pathway_Homo sapiens_hsa040240.88083774
70Glioma_Homo sapiens_hsa052140.87889388
71Bladder cancer_Homo sapiens_hsa052190.85762364
72Melanoma_Homo sapiens_hsa052180.85528057
73Oxytocin signaling pathway_Homo sapiens_hsa049210.83713299
74Renin secretion_Homo sapiens_hsa049240.82939045
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81719408
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81309628
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80692795
78Protein digestion and absorption_Homo sapiens_hsa049740.78149625
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76695421
80Sulfur metabolism_Homo sapiens_hsa009200.73652341
81Sulfur relay system_Homo sapiens_hsa041220.72800252
82ErbB signaling pathway_Homo sapiens_hsa040120.72391785
83Proteoglycans in cancer_Homo sapiens_hsa052050.72027790
84Linoleic acid metabolism_Homo sapiens_hsa005910.70523275
85Estrogen signaling pathway_Homo sapiens_hsa049150.70008516
86Cocaine addiction_Homo sapiens_hsa050300.67609439
87Prolactin signaling pathway_Homo sapiens_hsa049170.65019645
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62988690
89FoxO signaling pathway_Homo sapiens_hsa040680.62631610
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.62440127
91Melanogenesis_Homo sapiens_hsa049160.62162141
92Insulin signaling pathway_Homo sapiens_hsa049100.62156925
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62092192
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61282323
95Colorectal cancer_Homo sapiens_hsa052100.60576655
96Spliceosome_Homo sapiens_hsa030400.60277805
97Phagosome_Homo sapiens_hsa041450.59422092
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59184980
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58982035
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58613789
101RNA polymerase_Homo sapiens_hsa030200.57670911
102Systemic lupus erythematosus_Homo sapiens_hsa053220.56277325
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56197767
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55261432
105Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54629097
106Gastric acid secretion_Homo sapiens_hsa049710.53617312
107VEGF signaling pathway_Homo sapiens_hsa043700.52361731
108Fructose and mannose metabolism_Homo sapiens_hsa000510.49278292
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48557326
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47740645
111Arginine and proline metabolism_Homo sapiens_hsa003300.47609202
112Fanconi anemia pathway_Homo sapiens_hsa034600.47477414
113Renal cell carcinoma_Homo sapiens_hsa052110.47147248
114mTOR signaling pathway_Homo sapiens_hsa041500.47121003
115Endometrial cancer_Homo sapiens_hsa052130.46941446
116Calcium signaling pathway_Homo sapiens_hsa040200.46936405
117Biosynthesis of amino acids_Homo sapiens_hsa012300.46635803
118Rap1 signaling pathway_Homo sapiens_hsa040150.44853771
119ECM-receptor interaction_Homo sapiens_hsa045120.44166357
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44041927
121RNA degradation_Homo sapiens_hsa030180.43005300
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42481371
123Prostate cancer_Homo sapiens_hsa052150.41642480
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40284397
125Endocytosis_Homo sapiens_hsa041440.40115065
126Hippo signaling pathway_Homo sapiens_hsa043900.39745547
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.39733495
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39688565
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38200698
130Bile secretion_Homo sapiens_hsa049760.37306604
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36903779
132Dilated cardiomyopathy_Homo sapiens_hsa054140.34645534
133Hedgehog signaling pathway_Homo sapiens_hsa043400.34171534
134Type II diabetes mellitus_Homo sapiens_hsa049300.33408117
135MAPK signaling pathway_Homo sapiens_hsa040100.32459349
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.32135798
137Glucagon signaling pathway_Homo sapiens_hsa049220.30747801
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.30444998
139Pyruvate metabolism_Homo sapiens_hsa006200.25763571
140Prion diseases_Homo sapiens_hsa050200.25745133
141Ras signaling pathway_Homo sapiens_hsa040140.25039159

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »