POU5F1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-serine metabolic process (GO:0006563)5.98082905
2* regulation of gene silencing by RNA (GO:0060966)5.46901801
3* regulation of posttranscriptional gene silencing (GO:0060147)5.46901801
4* regulation of gene silencing by miRNA (GO:0060964)5.46901801
5L-alpha-amino acid transmembrane transport (GO:1902475)5.03257354
6folic acid-containing compound biosynthetic process (GO:0009396)4.98363683
7nuclear pore organization (GO:0006999)4.69586430
8establishment of viral latency (GO:0019043)4.61965154
9DNA replication-dependent nucleosome organization (GO:0034723)4.59147603
10DNA replication-dependent nucleosome assembly (GO:0006335)4.59147603
11nucleobase biosynthetic process (GO:0046112)4.57290659
12protein localization to kinetochore (GO:0034501)4.41056276
13mitotic metaphase plate congression (GO:0007080)4.32876139
14DNA replication initiation (GO:0006270)4.32640291
15DNA unwinding involved in DNA replication (GO:0006268)4.30870549
16formation of translation preinitiation complex (GO:0001731)4.29731716
17IMP biosynthetic process (GO:0006188)4.28249846
18nuclear pore complex assembly (GO:0051292)4.28187662
19regulation of helicase activity (GO:0051095)4.27665829
20purine nucleobase biosynthetic process (GO:0009113)4.21367705
21lung-associated mesenchyme development (GO:0060484)4.19742736
22cellular protein complex localization (GO:0034629)4.12847797
23pre-miRNA processing (GO:0031054)4.11023054
24ribosome assembly (GO:0042255)4.10553948
25mitotic nuclear envelope disassembly (GO:0007077)4.08589889
26somatic diversification of immune receptors via somatic mutation (GO:0002566)4.08488028
27somatic hypermutation of immunoglobulin genes (GO:0016446)4.08488028
28paraxial mesoderm development (GO:0048339)4.07297286
29maturation of SSU-rRNA (GO:0030490)4.00380784
30mitotic sister chromatid segregation (GO:0000070)3.91917806
31regulation of translational fidelity (GO:0006450)3.89563130
32establishment of apical/basal cell polarity (GO:0035089)3.88963806
33negative regulation of androgen receptor signaling pathway (GO:0060766)3.83409166
34nuclear envelope disassembly (GO:0051081)3.81673485
35membrane disassembly (GO:0030397)3.81673485
36heterochromatin organization (GO:0070828)3.79709834
37DNA strand elongation involved in DNA replication (GO:0006271)3.79443942
38negative regulation of histone methylation (GO:0031061)3.76056416
39regulation of histone H3-K9 methylation (GO:0051570)3.75599681
40ribosome biogenesis (GO:0042254)3.75197482
41* positive regulation of SMAD protein import into nucleus (GO:0060391)3.70881674
42IMP metabolic process (GO:0046040)3.69704790
43serine family amino acid biosynthetic process (GO:0009070)3.68304956
44histone arginine methylation (GO:0034969)3.65734936
45regulation of stem cell maintenance (GO:2000036)3.65410620
46metaphase plate congression (GO:0051310)3.64765842
47convergent extension (GO:0060026)3.64732261
48determination of adult lifespan (GO:0008340)3.64587241
49regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.63652193
50protein localization to chromosome, centromeric region (GO:0071459)3.63464998
51DNA strand elongation (GO:0022616)3.58403348
52regulation of translational termination (GO:0006449)3.50673438
53peptidyl-arginine omega-N-methylation (GO:0035247)3.50103478
54ribonucleoprotein complex biogenesis (GO:0022613)3.48400031
55* regulation of cell fate specification (GO:0042659)3.48395995
56regulation of spindle organization (GO:0090224)3.47708089
57positive regulation of chromosome segregation (GO:0051984)3.46359293
58regulation of hippo signaling (GO:0035330)3.45883856
59protein K6-linked ubiquitination (GO:0085020)3.45763076
60DNA duplex unwinding (GO:0032508)3.45098457
61DNA geometric change (GO:0032392)3.45026541
62nodal signaling pathway (GO:0038092)3.44736794
63negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.44446944
64nucleosome disassembly (GO:0006337)3.44206401
65protein-DNA complex disassembly (GO:0032986)3.44206401
66negative regulation of translation, ncRNA-mediated (GO:0040033)3.43567063
67regulation of translation, ncRNA-mediated (GO:0045974)3.43567063
68negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.43567063
69ribosomal large subunit biogenesis (GO:0042273)3.42821318
70anterior/posterior axis specification, embryo (GO:0008595)3.42727659
71sister chromatid segregation (GO:0000819)3.41533331
72regulation of mitotic spindle organization (GO:0060236)3.41271927
73notochord development (GO:0030903)3.36558250
74regulation of telomere maintenance via telomerase (GO:0032210)3.35989363
75establishment or maintenance of monopolar cell polarity (GO:0061339)3.30077369
76establishment of monopolar cell polarity (GO:0061162)3.30077369
77viral transcription (GO:0019083)3.26697881
78translational termination (GO:0006415)3.26385470
79pore complex assembly (GO:0046931)3.26320202
80translational initiation (GO:0006413)3.23902436
81mitotic sister chromatid cohesion (GO:0007064)3.22010923
82DNA replication checkpoint (GO:0000076)3.21217787
83telomere maintenance via semi-conservative replication (GO:0032201)3.19624854
84negative regulation of cell fate specification (GO:0009996)3.17574059
85histone H2A monoubiquitination (GO:0035518)3.17019889
86folic acid metabolic process (GO:0046655)3.16761384
87protein complex localization (GO:0031503)3.15283711
88ribosomal small subunit biogenesis (GO:0042274)3.14909864
89ribosomal small subunit assembly (GO:0000028)3.14619948
90establishment of chromosome localization (GO:0051303)3.14187531
91single strand break repair (GO:0000012)3.13523726
92regulation of centrosome cycle (GO:0046605)3.13256086
93CENP-A containing nucleosome assembly (GO:0034080)3.12961298
94positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.12021064
95positive regulation of cell cycle G2/M phase transition (GO:1902751)3.12021064
96histone H4-K12 acetylation (GO:0043983)3.11883502
97ATP-dependent chromatin remodeling (GO:0043044)3.11744132
98rRNA processing (GO:0006364)3.10834511
99negative regulation of cell fate commitment (GO:0010454)3.09387507
100DNA replication-independent nucleosome organization (GO:0034724)3.08071070
101DNA replication-independent nucleosome assembly (GO:0006336)3.08071070
102translational elongation (GO:0006414)3.06695844
103chaperone-mediated protein complex assembly (GO:0051131)3.04410335
104polarized epithelial cell differentiation (GO:0030859)3.04214033
105* regulation of gene silencing (GO:0060968)3.03814348
106rRNA metabolic process (GO:0016072)3.01417160
107negative regulation of mRNA processing (GO:0050686)3.01018793
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00875338
109chromatin remodeling at centromere (GO:0031055)2.99326746
110mitotic chromosome condensation (GO:0007076)2.98702591
111regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.97605284
112nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.97419748
113negative regulation of chromosome segregation (GO:0051985)2.96884838
114negative regulation of telomerase activity (GO:0051974)2.96493234
115regulation of chromosome segregation (GO:0051983)2.96167764
116peptidyl-arginine methylation (GO:0018216)2.95935947
117peptidyl-arginine N-methylation (GO:0035246)2.95935947
118regulation of nuclear cell cycle DNA replication (GO:0033262)2.95670334
119nuclear envelope organization (GO:0006998)2.95570160
120lysine metabolic process (GO:0006553)2.94571748
121lysine catabolic process (GO:0006554)2.94571748
122negative regulation of RNA splicing (GO:0033119)2.94228576
123spliceosomal snRNP assembly (GO:0000387)2.94155044
124chromatin assembly (GO:0031497)2.93101173
125glycine metabolic process (GO:0006544)2.92351598
126ncRNA catabolic process (GO:0034661)2.90494344
127tetrahydrofolate metabolic process (GO:0046653)2.90362213
128regulation of sister chromatid cohesion (GO:0007063)2.88920171
129telomere maintenance via telomere lengthening (GO:0010833)2.88662214
130negative regulation of mRNA metabolic process (GO:1903312)2.87171792
131planar cell polarity pathway involved in neural tube closure (GO:0090179)2.86906916
132serine family amino acid catabolic process (GO:0009071)2.86809470
133cell migration involved in gastrulation (GO:0042074)2.86730945
134pteridine-containing compound biosynthetic process (GO:0042559)2.86404712
135homocysteine metabolic process (GO:0050667)2.86339891
136histone exchange (GO:0043486)2.85923661
137glomerular visceral epithelial cell development (GO:0072015)2.85341658
138spliceosomal tri-snRNP complex assembly (GO:0000244)2.84359903
139chromatin assembly or disassembly (GO:0006333)2.83153358
140negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81282782
141negative regulation of sister chromatid segregation (GO:0033046)2.81282782
142negative regulation of mitotic sister chromatid separation (GO:2000816)2.81282782
143negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81282782
144spindle assembly involved in mitosis (GO:0090307)2.80526632
145establishment of integrated proviral latency (GO:0075713)2.80334265
146non-recombinational repair (GO:0000726)2.79934349

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.55052647
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.11639293
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.90127979
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.46102292
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.46102292
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.46102292
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.36833351
8POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.04025812
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02355981
10* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.01091771
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.89176597
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74691450
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66506974
14* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.53703582
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.53221571
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49382814
17* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.40298534
18* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.28295348
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22256630
20POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.14927267
21* SOX2_16153702_ChIP-ChIP_HESCs_Human2.13810465
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13607594
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.10697090
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.08455194
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06656140
26* STAT3_1855785_ChIP-Seq_MESCs_Mouse2.05894092
27* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.02554884
28XRN2_22483619_ChIP-Seq_HELA_Human2.02183469
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02041406
30* NANOG_16153702_ChIP-ChIP_HESCs_Human2.00566759
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.93447692
32* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.92952450
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90803717
34* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.90626429
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88659629
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88470507
37* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.88463935
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87808396
39* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.87751746
40* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.85424202
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79710454
42* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79167606
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78962045
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76512536
45* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.74134394
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.71723063
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68762784
48AR_21909140_ChIP-Seq_LNCAP_Human1.68318552
49* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.68249712
50* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.65362660
51ZNF263_19887448_ChIP-Seq_K562_Human1.63220613
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62311235
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.61569411
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60129408
55* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.59197797
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.58163746
57* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.54507396
58* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.50891202
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49737620
60TTF2_22483619_ChIP-Seq_HELA_Human1.45202224
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.45029632
62* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45018124
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44242986
64VDR_23849224_ChIP-Seq_CD4+_Human1.42752123
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41728681
66* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40116469
67* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.39683100
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.39218475
69* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38345382
70* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.38045510
71* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.38006142
72* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.37845321
73* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.36808497
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.35481600
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34021446
76DCP1A_22483619_ChIP-Seq_HELA_Human1.33097851
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30964786
78MYC_22102868_ChIP-Seq_BL_Human1.30660925
79GABP_19822575_ChIP-Seq_HepG2_Human1.30384228
80* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28915324
81FOXP3_21729870_ChIP-Seq_TREG_Human1.28330959
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27108767
83* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26442697
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26298074
85KDM5A_27292631_Chip-Seq_BREAST_Human1.24635705
86* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.21530917
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21224149
88* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.19820818
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13870090
90CIITA_25753668_ChIP-Seq_RAJI_Human1.11742623
91TP63_17297297_ChIP-ChIP_HaCaT_Human1.11615064
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07963910
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06272086
94TFEB_21752829_ChIP-Seq_HELA_Human1.06117887
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04670420
96* KAP1_27257070_Chip-Seq_ESCs_Mouse1.04110766
97PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03645988
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02808370
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02589314
100* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02082514
101* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01800162
102HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01618043
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01139197
104* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99416300
105* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98589204
106ERG_21242973_ChIP-ChIP_JURKAT_Human0.97435290
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.97017860
108* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94512569
109ELK1_19687146_ChIP-ChIP_HELA_Human0.92042921
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91114218
111TP63_19390658_ChIP-ChIP_HaCaT_Human0.90736697
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89918274
113IRF1_19129219_ChIP-ChIP_H3396_Human0.88958739
114* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.86945960
115EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86372523
116* NANOG_16518401_ChIP-PET_MESCs_Mouse0.86257129
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84050144
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82817784
119* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82757852

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat7.19698157
2MP0003693_abnormal_embryo_hatching4.30161937
3MP0003111_abnormal_nucleus_morphology4.28526625
4* MP0004957_abnormal_blastocyst_morpholog4.12332584
5MP0010094_abnormal_chromosome_stability4.01952024
6MP0003077_abnormal_cell_cycle3.58938316
7MP0008057_abnormal_DNA_replication3.31821093
8MP0002653_abnormal_ependyma_morphology3.29564225
9MP0003806_abnormal_nucleotide_metabolis3.25056755
10MP0010352_gastrointestinal_tract_polyps2.75438250
11MP0003941_abnormal_skin_development2.74753971
12MP0004133_heterotaxia2.69015265
13MP0008058_abnormal_DNA_repair2.65942109
14MP0001730_embryonic_growth_arrest2.58839473
15MP0003136_yellow_coat_color2.41257109
16MP0003123_paternal_imprinting2.39487960
17MP0000350_abnormal_cell_proliferation2.35717956
18MP0008932_abnormal_embryonic_tissue2.34254001
19MP0008007_abnormal_cellular_replicative2.20224005
20MP0010307_abnormal_tumor_latency2.16315115
21MP0002084_abnormal_developmental_patter2.12956048
22MP0001672_abnormal_embryogenesis/_devel2.09097859
23MP0005380_embryogenesis_phenotype2.09097859
24* MP0002085_abnormal_embryonic_tissue2.04116089
25MP0001697_abnormal_embryo_size1.92163886
26MP0003890_abnormal_embryonic-extraembry1.87687140
27MP0003718_maternal_effect1.83394415
28MP0002086_abnormal_extraembryonic_tissu1.81892644
29MP0003984_embryonic_growth_retardation1.79277421
30MP0003119_abnormal_digestive_system1.79028339
31MP0004197_abnormal_fetal_growth/weight/1.78988429
32MP0002088_abnormal_embryonic_growth/wei1.75940157
33MP0005076_abnormal_cell_differentiation1.73585495
34MP0001293_anophthalmia1.72762599
35* MP0002080_prenatal_lethality1.72294872
36MP0010030_abnormal_orbit_morphology1.71748980
37MP0003786_premature_aging1.71319046
38MP0001849_ear_inflammation1.71085740
39MP0003283_abnormal_digestive_organ1.69812203
40MP0008877_abnormal_DNA_methylation1.68750258
41MP0000566_synostosis1.55714236
42MP0010234_abnormal_vibrissa_follicle1.52523649
43MP0003705_abnormal_hypodermis_morpholog1.49641121
44MP0003121_genomic_imprinting1.31545160
45MP0003566_abnormal_cell_adhesion1.28680186
46MP0003878_abnormal_ear_physiology1.28135440
47MP0005377_hearing/vestibular/ear_phenot1.28135440
48MP0000537_abnormal_urethra_morphology1.25649304
49MP0001299_abnormal_eye_distance/1.24813673
50MP0000049_abnormal_middle_ear1.20130904
51MP0005501_abnormal_skin_physiology1.19737840
52MP0009278_abnormal_bone_marrow1.19717838
53MP0003567_abnormal_fetal_cardiomyocyte1.17076732
54MP0000313_abnormal_cell_death1.16827261
55MP0002210_abnormal_sex_determination1.11493491
56MP0001188_hyperpigmentation1.10993018
57MP0006292_abnormal_olfactory_placode1.10599864
58MP0002111_abnormal_tail_morphology1.09377778
59MP0001145_abnormal_male_reproductive1.09324552
60MP0002796_impaired_skin_barrier1.08962348
61MP0001661_extended_life_span1.08201984
62MP0002089_abnormal_postnatal_growth/wei1.04071583
63MP0002019_abnormal_tumor_incidence1.03791974
64MP0000490_abnormal_crypts_of1.03022693
65MP0000467_abnormal_esophagus_morphology1.01815712
66MP0002697_abnormal_eye_size1.00392544
67MP0003937_abnormal_limbs/digits/tail_de0.99952854
68MP0004264_abnormal_extraembryonic_tissu0.99292136
69MP0005623_abnormal_meninges_morphology0.97531443
70MP0009053_abnormal_anal_canal0.97378719
71MP0003787_abnormal_imprinting0.96431093
72MP0000579_abnormal_nail_morphology0.95638618
73MP0005266_abnormal_metabolism0.95330549
74MP0002249_abnormal_larynx_morphology0.94518175
75MP0001286_abnormal_eye_development0.94497105
76MP0002163_abnormal_gland_morphology0.92885603
77MP0000358_abnormal_cell_content/0.92530671
78MP0004858_abnormal_nervous_system0.91807213
79MP0003861_abnormal_nervous_system0.91218050
80MP0001915_intracranial_hemorrhage0.89128341
81MP0005367_renal/urinary_system_phenotyp0.88246004
82MP0000516_abnormal_urinary_system0.88246004
83MP0002092_abnormal_eye_morphology0.88057253
84MP0003315_abnormal_perineum_morphology0.87602085
85MP0004185_abnormal_adipocyte_glucose0.86975663
86MP0002877_abnormal_melanocyte_morpholog0.86566558
87MP0000653_abnormal_sex_gland0.85511300
88MP0005023_abnormal_wound_healing0.85456041
89MP0001929_abnormal_gametogenesis0.84227135
90MP0009672_abnormal_birth_weight0.82587498
91MP0006035_abnormal_mitochondrial_morpho0.82305336
92MP0005384_cellular_phenotype0.81923414
93MP0002233_abnormal_nose_morphology0.81501423
94MP0003115_abnormal_respiratory_system0.79555493
95MP0009703_decreased_birth_body0.79385334
96MP0002160_abnormal_reproductive_system0.78706268
97MP0005621_abnormal_cell_physiology0.78515871
98MP0003950_abnormal_plasma_membrane0.78033136
99MP0000432_abnormal_head_morphology0.77614353
100MP0000762_abnormal_tongue_morphology0.74720627
101MP0005257_abnormal_intraocular_pressure0.74539578
102MP0004233_abnormal_muscle_weight0.73438732
103MP0001177_atelectasis0.71411054
104MP0010630_abnormal_cardiac_muscle0.71092010
105MP0008770_decreased_survivor_rate0.70379435
106MP0003936_abnormal_reproductive_system0.70227179
107MP0003453_abnormal_keratinocyte_physiol0.69113602
108MP0002396_abnormal_hematopoietic_system0.67849472
109MP0001348_abnormal_lacrimal_gland0.67691920
110MP0002938_white_spotting0.67425178
111MP0004272_abnormal_basement_membrane0.67025066
112MP0002090_abnormal_vision0.66505601
113MP0002081_perinatal_lethality0.64531541
114MP0005395_other_phenotype0.64471690
115MP0000858_altered_metastatic_potential0.63383523
116MP0002925_abnormal_cardiovascular_devel0.62933438
117MP0002127_abnormal_cardiovascular_syste0.62692089
118MP0003755_abnormal_palate_morphology0.62446650
119MP0003942_abnormal_urinary_system0.61480172
120MP0000428_abnormal_craniofacial_morphol0.61386718
121MP0005389_reproductive_system_phenotype0.61268499
122MP0000462_abnormal_digestive_system0.61153505
123MP0002269_muscular_atrophy0.61013953
124MP0009697_abnormal_copulation0.60959639
125MP0000477_abnormal_intestine_morphology0.60168083
126MP0003935_abnormal_craniofacial_develop0.59149378
127MP0003186_abnormal_redox_activity0.58078139
128MP0003938_abnormal_ear_development0.57372038
129MP0000678_abnormal_parathyroid_gland0.56407085
130MP0005379_endocrine/exocrine_gland_phen0.55813980
131MP0003699_abnormal_female_reproductive0.55600082
132MP0003122_maternal_imprinting0.55579611
133MP0001346_abnormal_lacrimal_gland0.55173521

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.87008106
2Astrocytoma (HP:0009592)4.47769170
3Abnormality of the astrocytes (HP:0100707)4.47769170
4Hepatoblastoma (HP:0002884)4.46372879
5Abnormality of the labia minora (HP:0012880)4.22319470
6Esophageal atresia (HP:0002032)3.84727096
7Breast hypoplasia (HP:0003187)3.82682990
8Medulloblastoma (HP:0002885)3.80675470
9Agnosia (HP:0010524)3.76816167
10Choanal stenosis (HP:0000452)3.70125243
11Missing ribs (HP:0000921)3.69385519
12Glioma (HP:0009733)3.68046247
13Birth length less than 3rd percentile (HP:0003561)3.63770287
14Rib fusion (HP:0000902)3.63130148
15Colon cancer (HP:0003003)3.62218887
16Absent radius (HP:0003974)3.58001378
17Neoplasm of the oral cavity (HP:0100649)3.54961663
18Cortical dysplasia (HP:0002539)3.50605373
19Supernumerary spleens (HP:0009799)3.41904937
20Absent forearm bone (HP:0003953)3.36611867
21Aplasia involving forearm bones (HP:0009822)3.36611867
22Bilateral microphthalmos (HP:0007633)3.33411234
23Nephroblastoma (Wilms tumor) (HP:0002667)3.29797351
24Rhabdomyosarcoma (HP:0002859)3.26271307
25Selective tooth agenesis (HP:0001592)3.26041503
26Aplasia/hypoplasia of the humerus (HP:0006507)3.24303466
27Embryonal renal neoplasm (HP:0011794)3.06114480
28Reticulocytopenia (HP:0001896)3.04108755
29Abnormality of abdominal situs (HP:0011620)3.03595755
30Abdominal situs inversus (HP:0003363)3.03595755
31Chromosomal breakage induced by crosslinking agents (HP:0003221)3.01336951
32Short humerus (HP:0005792)3.00311356
33Carpal bone hypoplasia (HP:0001498)2.96805827
34Chromsome breakage (HP:0040012)2.96730563
35Hyperglycinuria (HP:0003108)2.85299622
36Chronic bronchitis (HP:0004469)2.81452171
37Patellar aplasia (HP:0006443)2.80247626
38Impulsivity (HP:0100710)2.73969297
39Neoplasm of striated muscle (HP:0009728)2.69792406
40Biliary tract neoplasm (HP:0100574)2.69555853
41Turricephaly (HP:0000262)2.68888838
42Rough bone trabeculation (HP:0100670)2.68186822
43Oral leukoplakia (HP:0002745)2.65580447
44Vertebral clefting (HP:0008428)2.65471935
45Gastrointestinal atresia (HP:0002589)2.65454745
46Abnormality of the salivary glands (HP:0010286)2.60953483
47Abnormal lung lobation (HP:0002101)2.59932635
48Hyperglycinemia (HP:0002154)2.59188434
49Aplasia/Hypoplasia of the patella (HP:0006498)2.58682674
50Skull defect (HP:0001362)2.58158036
51Absent thumb (HP:0009777)2.57922679
52Shawl scrotum (HP:0000049)2.55865410
53Spastic diplegia (HP:0001264)2.55024967
54Cerebral hypomyelination (HP:0006808)2.52315070
55Short hallux (HP:0010109)2.50416779
56Maternal diabetes (HP:0009800)2.49772593
57Bronchomalacia (HP:0002780)2.47178440
58Neoplasm of the pancreas (HP:0002894)2.45851675
59Basal cell carcinoma (HP:0002671)2.45079893
60Supernumerary bones of the axial skeleton (HP:0009144)2.42962134
61Abnormal number of incisors (HP:0011064)2.42683057
62Increased nuchal translucency (HP:0010880)2.39668944
63Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.38952870
64Aplasia/Hypoplasia of the hallux (HP:0008362)2.38437153
65Supernumerary ribs (HP:0005815)2.37243050
66Neoplasm of the adrenal cortex (HP:0100641)2.34410107
67Abnormality of glycine metabolism (HP:0010895)2.33823349
68Abnormality of serine family amino acid metabolism (HP:0010894)2.33823349
69Abnormality of homocysteine metabolism (HP:0010919)2.33494433
70Homocystinuria (HP:0002156)2.33494433
71Meckel diverticulum (HP:0002245)2.31783905
72Abnormality of the ileum (HP:0001549)2.28048979
73Partial duplication of thumb phalanx (HP:0009944)2.27498081
74Aplasia involving bones of the extremities (HP:0009825)2.26770645
75Aplasia involving bones of the upper limbs (HP:0009823)2.26770645
76Aplasia of the phalanges of the hand (HP:0009802)2.26770645
77Premature ovarian failure (HP:0008209)2.26553098
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.25335248
79Asplenia (HP:0001746)2.24371275
80Degeneration of anterior horn cells (HP:0002398)2.23315634
81Abnormality of the anterior horn cell (HP:0006802)2.23315634
82Trismus (HP:0000211)2.23304278
83Hypoglycemic seizures (HP:0002173)2.22291432
84Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.21655926
85Vertebral hypoplasia (HP:0008417)2.21655926
86Vaginal fistula (HP:0004320)2.21183051
87Deviation of the thumb (HP:0009603)2.18991477
88Proximal placement of thumb (HP:0009623)2.18571757
89Duplication of thumb phalanx (HP:0009942)2.17068641
90Shallow orbits (HP:0000586)2.14979748
91Shoulder girdle muscle weakness (HP:0003547)2.14703219
92Multiple enchondromatosis (HP:0005701)2.14564413
93Hemivertebrae (HP:0002937)2.14483566
94Tracheoesophageal fistula (HP:0002575)2.14277652
95Myelomeningocele (HP:0002475)2.14148414
96Abnormality of chromosome stability (HP:0003220)2.12774643
97Cutaneous syndactyly (HP:0012725)2.12417916
98Embryonal neoplasm (HP:0002898)2.09941022
99Rectal fistula (HP:0100590)2.09149705
100Rectovaginal fistula (HP:0000143)2.09149705
101Stenosis of the external auditory canal (HP:0000402)2.09134323
102Dysmetric saccades (HP:0000641)2.08930665
103Angiofibromas (HP:0010615)2.08930045
104Adenoma sebaceum (HP:0009720)2.08930045
105Broad thumb (HP:0011304)2.08586031
106Gastrointestinal carcinoma (HP:0002672)2.08480641
107Malignant gastrointestinal tract tumors (HP:0006749)2.08480641
108Abnormality of the preputium (HP:0100587)2.08378356
109Breast aplasia (HP:0100783)2.08148722
110Abnormality of the septum pellucidum (HP:0007375)2.07901124
111Humeroradial synostosis (HP:0003041)2.07567086
112Synostosis involving the elbow (HP:0003938)2.07567086
113Amaurosis fugax (HP:0100576)2.05964735
114Aplasia/Hypoplasia of the sternum (HP:0006714)2.04726307
115Vertebral fusion (HP:0002948)2.04505554
116Uterine neoplasm (HP:0010784)2.04248842
117Duodenal stenosis (HP:0100867)2.04107053
118Small intestinal stenosis (HP:0012848)2.04107053
119Abnormality of the lower motor neuron (HP:0002366)2.03557715
120Coronal craniosynostosis (HP:0004440)2.01571433
121Absent eyebrow (HP:0002223)2.01525212
122Duplicated collecting system (HP:0000081)2.01191506
123Generalized hypotonia (HP:0001290)2.00842119
124Overriding aorta (HP:0002623)2.00641047
125Horseshoe kidney (HP:0000085)1.99888248
126Aplasia/Hypoplasia of the spleen (HP:0010451)1.99730678
127Septo-optic dysplasia (HP:0100842)1.99563141
128Spinal muscular atrophy (HP:0007269)1.99476976
129Abnormality of cells of the erythroid lineage (HP:0012130)1.99148023
130Abnormality of the lacrimal duct (HP:0011481)1.97663049
131Absent septum pellucidum (HP:0001331)1.97090418
132Absent eyelashes (HP:0000561)1.95986641
133Intestinal fistula (HP:0100819)1.95919837
134Abnormality of pyrimidine metabolism (HP:0004353)1.95753441
135Pseudobulbar signs (HP:0002200)1.95165946
136Neoplasm of the colon (HP:0100273)1.93034115
137Anophthalmia (HP:0000528)1.93001839
138Atresia of the external auditory canal (HP:0000413)1.92036418
13911 pairs of ribs (HP:0000878)1.91742577
140Aqueductal stenosis (HP:0002410)1.89947402
141Cafe-au-lait spot (HP:0000957)1.89525633
142Aplasia/Hypoplasia of the breasts (HP:0010311)1.88865399
143Abnormal trabecular bone morphology (HP:0100671)1.88589307
144Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.87949948
145Metaphyseal cupping (HP:0003021)1.87937768
146Abnormality of the duodenum (HP:0002246)1.86207871
147Broad metatarsal (HP:0001783)1.85802411
148Fused cervical vertebrae (HP:0002949)1.85133396
149Squamous cell carcinoma (HP:0002860)1.84742780
150Preaxial foot polydactyly (HP:0001841)1.84028717
151Partial duplication of the phalanx of hand (HP:0009999)1.83541367
152Delayed puberty (HP:0000823)1.83134084
153Clitoromegaly (HP:0000057)1.82819800
154High anterior hairline (HP:0009890)1.81931869
155Bifid tongue (HP:0010297)1.81761827
156Facial cleft (HP:0002006)1.80344037
157Arnold-Chiari malformation (HP:0002308)1.79667520
158Ectopic kidney (HP:0000086)1.79130049
159Leiomyosarcoma (HP:0100243)1.78989194
160Uterine leiomyosarcoma (HP:0002891)1.78989194
161Progressive external ophthalmoplegia (HP:0000590)1.78979212
162Abnormality of the middle phalanges of the toes (HP:0010183)1.76668229

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.46088024
2BUB14.18529364
3WEE13.95107456
4CDK193.49835328
5NEK13.32091374
6SMG13.29432942
7CDC73.29286080
8CDK123.18697254
9TAF12.87848510
10TTK2.86433840
11TSSK62.79478736
12RPS6KB22.67981130
13EEF2K2.66457274
14VRK22.65106599
15NEK22.49495914
16PNCK2.04213554
17PLK11.91195238
18CDK71.90514958
19PASK1.87606242
20LATS21.75650008
21FGFR21.66592677
22AKT31.65840217
23SRPK11.60999810
24CHEK21.52556041
25MAPKAPK31.51080484
26PAK41.49621915
27PLK31.45343434
28TESK21.43667408
29EIF2AK11.42950280
30MAP3K81.41519398
31ALK1.40957181
32CAMK1D1.40839125
33AURKB1.40631754
34ATR1.40159255
35TLK11.39006458
36AURKA1.38282015
37CHEK11.36513482
38CDK41.35282788
39TNIK1.31252789
40FGFR41.30646548
41FLT31.29912762
42CAMK1G1.29589347
43STK241.29094870
44BRD41.24544832
45KDR1.17549208
46DYRK31.15575825
47STK38L1.13549809
48PRKCI1.03391027
49CDK21.00211557
50ICK0.99226563
51MET0.98048393
52PKN20.97222308
53ACVR1B0.96720481
54STK100.94861378
55MTOR0.94782845
56VRK10.94750269
57NME20.90036585
58ATM0.89813434
59LATS10.88199643
60PDK30.86770327
61PDK40.86770327
62PLK40.85153291
63ZAK0.84510002
64MKNK10.83905892
65BRSK20.82098079
66TGFBR10.79065796
67SCYL20.78841503
68STK40.78802266
69ERBB40.78314954
70CDK60.78217672
71NTRK10.77383833
72CSNK1E0.77049654
73MAP3K90.76398816
74CSNK1G10.75583966
75CSNK2A20.75247654
76PAK10.71677307
77EIF2AK30.71485474
78DMPK0.70593982
79MAP3K100.70553168
80OXSR10.70538498
81PDK20.70534987
82AKT20.68419445
83PIM20.67995287
84CDK10.67564674
85KSR20.64429857
86PRKG20.64166844
87MKNK20.63104458
88CSNK1D0.61937297
89MELK0.61628960
90PDGFRA0.60199233
91TIE10.59345128
92BCKDK0.57478994
93DYRK20.57394470
94BRAF0.56499268
95TTN0.56338123
96RAF10.55650278
97PAK20.54912415
98NUAK10.54387915
99DAPK10.54124141
100TYRO30.53813162
101EIF2AK20.52649986
102CSNK1G20.52225469
103EGFR0.52196150
104NME10.52126018
105CSNK2A10.50198646
106BRSK10.49745674
107FGFR10.47619185
108BMX0.47091046
109NLK0.46003247
110PTK20.44731171
111PRKDC0.42926272
112CDK11A0.41487507
113STK30.40451110
114MST40.40133482
115* PIM10.39727430
116CSNK1G30.38998760
117LRRK20.37602787
118GRK60.36439529
119DYRK1A0.36219238
120CDK150.35277845
121FGR0.34844732
122PAK60.34745085
123RPS6KA40.34469333
124MAPK140.34455247
125MAPK90.33680230
126PBK0.33374852
127YES10.33194682
128CDK180.32529296
129GSK3B0.32034529
130STK160.31696822
131AKT10.30248814
132MAP2K20.30115289
133RPS6KA10.29190802
134* MAPK10.28872821
135DDR20.27740481
136RPS6KA50.27080311
137MAPK100.25919987

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.43990141
2DNA replication_Homo sapiens_hsa030304.26002185
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.09531181
4One carbon pool by folate_Homo sapiens_hsa006703.61205480
5RNA transport_Homo sapiens_hsa030133.50031727
6Spliceosome_Homo sapiens_hsa030403.31307914
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.21478345
8Ribosome_Homo sapiens_hsa030103.05668854
9RNA polymerase_Homo sapiens_hsa030203.04371091
10Nucleotide excision repair_Homo sapiens_hsa034202.72884308
11Cell cycle_Homo sapiens_hsa041102.59526103
12Base excision repair_Homo sapiens_hsa034102.59211873
13Homologous recombination_Homo sapiens_hsa034402.58898460
14Proteasome_Homo sapiens_hsa030502.46963487
15Fanconi anemia pathway_Homo sapiens_hsa034602.04543994
16Pyrimidine metabolism_Homo sapiens_hsa002401.98307297
17mRNA surveillance pathway_Homo sapiens_hsa030151.97400500
18p53 signaling pathway_Homo sapiens_hsa041151.77152764
19RNA degradation_Homo sapiens_hsa030181.76428581
20Non-homologous end-joining_Homo sapiens_hsa034501.68582203
21Basal transcription factors_Homo sapiens_hsa030221.67651215
22Biosynthesis of amino acids_Homo sapiens_hsa012301.64719707
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58034828
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38247104
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28308936
26Steroid biosynthesis_Homo sapiens_hsa001001.28093013
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.24950155
28* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19203060
29Selenocompound metabolism_Homo sapiens_hsa004501.17766822
30Hippo signaling pathway_Homo sapiens_hsa043901.15621942
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.14002713
32Oocyte meiosis_Homo sapiens_hsa041141.13885398
33Purine metabolism_Homo sapiens_hsa002301.04512868
34Systemic lupus erythematosus_Homo sapiens_hsa053221.03316018
35Epstein-Barr virus infection_Homo sapiens_hsa051691.03034093
36Fructose and mannose metabolism_Homo sapiens_hsa000510.99848860
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97178726
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96442004
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94746151
40Viral carcinogenesis_Homo sapiens_hsa052030.94694223
41Folate biosynthesis_Homo sapiens_hsa007900.92374161
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91898791
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91106981
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91008539
45Carbon metabolism_Homo sapiens_hsa012000.90295273
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89143083
47Pentose phosphate pathway_Homo sapiens_hsa000300.87657745
48Basal cell carcinoma_Homo sapiens_hsa052170.87050076
49Bladder cancer_Homo sapiens_hsa052190.85846205
50MicroRNAs in cancer_Homo sapiens_hsa052060.85341605
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82827872
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.82004157
53Vitamin B6 metabolism_Homo sapiens_hsa007500.80603966
54TGF-beta signaling pathway_Homo sapiens_hsa043500.77538860
55Thyroid cancer_Homo sapiens_hsa052160.70211756
56Tight junction_Homo sapiens_hsa045300.68343093
57Notch signaling pathway_Homo sapiens_hsa043300.67532055
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.67012312
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66944281
60mTOR signaling pathway_Homo sapiens_hsa041500.66450177
61Hedgehog signaling pathway_Homo sapiens_hsa043400.66101766
62Small cell lung cancer_Homo sapiens_hsa052220.64900928
63Adherens junction_Homo sapiens_hsa045200.62893179
64HTLV-I infection_Homo sapiens_hsa051660.59549874
65Glutathione metabolism_Homo sapiens_hsa004800.56787109
66Vitamin digestion and absorption_Homo sapiens_hsa049770.54878245
67Fatty acid elongation_Homo sapiens_hsa000620.52796874
68Sulfur relay system_Homo sapiens_hsa041220.51115279
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49792499
70Arginine and proline metabolism_Homo sapiens_hsa003300.49599348
71Colorectal cancer_Homo sapiens_hsa052100.49318340
72HIF-1 signaling pathway_Homo sapiens_hsa040660.46094753
73Nitrogen metabolism_Homo sapiens_hsa009100.44217212
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42570814
75Antigen processing and presentation_Homo sapiens_hsa046120.40230149
76Herpes simplex infection_Homo sapiens_hsa051680.39233775
77Pathways in cancer_Homo sapiens_hsa052000.38850012
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38116948
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36827584
80Galactose metabolism_Homo sapiens_hsa000520.35968418
81Alcoholism_Homo sapiens_hsa050340.35198578
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34611934
83Fatty acid metabolism_Homo sapiens_hsa012120.34283701
84Melanogenesis_Homo sapiens_hsa049160.32182154
85Lysine degradation_Homo sapiens_hsa003100.31426537
86Renin-angiotensin system_Homo sapiens_hsa046140.31253305
87Propanoate metabolism_Homo sapiens_hsa006400.31251226
88Melanoma_Homo sapiens_hsa052180.30628784
89Wnt signaling pathway_Homo sapiens_hsa043100.30532329
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30020839
91Rap1 signaling pathway_Homo sapiens_hsa040150.28901001
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28793806
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28135348
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27156311
95Axon guidance_Homo sapiens_hsa043600.26626224
96Insulin signaling pathway_Homo sapiens_hsa049100.26543998
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25371323
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22455192
99Huntingtons disease_Homo sapiens_hsa050160.20968925
100Apoptosis_Homo sapiens_hsa042100.20008115
101Pyruvate metabolism_Homo sapiens_hsa006200.18033205
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17749377
103N-Glycan biosynthesis_Homo sapiens_hsa005100.17597914
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17193790
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16864789
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.15742091
107Prion diseases_Homo sapiens_hsa050200.13902007
108Proteoglycans in cancer_Homo sapiens_hsa052050.13853621
109Legionellosis_Homo sapiens_hsa051340.13075956
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12975612
111Prostate cancer_Homo sapiens_hsa052150.12370616
112Metabolic pathways_Homo sapiens_hsa011000.11251130
113Arginine biosynthesis_Homo sapiens_hsa002200.10404285
114Chronic myeloid leukemia_Homo sapiens_hsa052200.09864618
115AMPK signaling pathway_Homo sapiens_hsa041520.09421293
116ECM-receptor interaction_Homo sapiens_hsa045120.09419704
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09395630
118Endometrial cancer_Homo sapiens_hsa052130.09377460
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09252431
120Renal cell carcinoma_Homo sapiens_hsa052110.06756266
121Glucagon signaling pathway_Homo sapiens_hsa049220.05103386

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