POU5F1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.68260807
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.68260807
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.68260807
4modulation by symbiont of host immune response (GO:0052553)6.68260807
5positive regulation by symbiont of host defense response (GO:0052509)6.68260807
6modulation by symbiont of host defense response (GO:0052031)6.68260807
7neutrophil activation involved in immune response (GO:0002283)6.22814152
8response to peptidoglycan (GO:0032494)5.79978470
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.79268508
10negative regulation of cell killing (GO:0031342)5.79268508
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.76865114
12cellular extravasation (GO:0045123)5.63182743
13detection of molecule of bacterial origin (GO:0032490)5.49864416
14positive regulation of gamma-delta T cell activation (GO:0046645)5.44102577
15negative regulation of interleukin-12 production (GO:0032695)5.39421145
16detection of other organism (GO:0098543)5.32871288
17macrophage activation involved in immune response (GO:0002281)5.28757906
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.25870174
19neutrophil activation (GO:0042119)5.03633099
20detection of external biotic stimulus (GO:0098581)4.85632276
21detection of bacterium (GO:0016045)4.82314576
22respiratory burst (GO:0045730)4.81567140
23granulocyte activation (GO:0036230)4.63903493
24regulation of interferon-beta biosynthetic process (GO:0045357)4.54776361
25leukocyte migration involved in inflammatory response (GO:0002523)4.53502371
26regulation of B cell receptor signaling pathway (GO:0050855)4.52261815
27antigen processing and presentation of endogenous antigen (GO:0019883)4.37027361
28detection of biotic stimulus (GO:0009595)4.28830675
29response to muramyl dipeptide (GO:0032495)4.28819138
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.28537205
31negative regulation of lymphocyte mediated immunity (GO:0002707)4.27168534
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.26384104
33response to host immune response (GO:0052572)4.26384104
34regulation of gamma-delta T cell activation (GO:0046643)4.12640859
35negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.10025700
36regulation of mast cell degranulation (GO:0043304)4.06431325
37macrophage activation (GO:0042116)4.03807443
38leukocyte aggregation (GO:0070486)4.02455409
39immunoglobulin mediated immune response (GO:0016064)3.99400745
40myeloid cell activation involved in immune response (GO:0002275)3.98423734
41microglial cell activation (GO:0001774)3.98190446
42production of molecular mediator involved in inflammatory response (GO:0002532)3.95802717
43regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.93507987
44neutrophil mediated immunity (GO:0002446)3.93233871
45germinal center formation (GO:0002467)3.86386551
46regulation of T-helper 2 cell differentiation (GO:0045628)3.84859458
47response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.84683450
48response to host (GO:0075136)3.84683450
49response to host defenses (GO:0052200)3.84683450
50positive regulation of mast cell activation (GO:0033005)3.81036682
51antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.77156977
52positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.72384926
53regulation of mast cell activation involved in immune response (GO:0033006)3.71174994
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.67028440
55negative regulation of leukocyte mediated immunity (GO:0002704)3.66059274
56negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.61199650
57negative regulation of T-helper cell differentiation (GO:0045623)3.61199650
58regulation of myeloid leukocyte mediated immunity (GO:0002886)3.60410366
59regulation of mast cell activation (GO:0033003)3.53915621
60leukocyte degranulation (GO:0043299)3.52648219
61neutrophil chemotaxis (GO:0030593)3.50947273
62regulation of leukocyte degranulation (GO:0043300)3.50473257
63defense response to protozoan (GO:0042832)3.47679042
64positive regulation of mast cell degranulation (GO:0043306)3.42475456
65positive regulation of mast cell activation involved in immune response (GO:0033008)3.42475456
66lipopolysaccharide-mediated signaling pathway (GO:0031663)3.42085615
67neutrophil migration (GO:1990266)3.41902356
68negative regulation of T cell mediated immunity (GO:0002710)3.40623208
69B cell mediated immunity (GO:0019724)3.40035372
70response to interleukin-15 (GO:0070672)3.38895472
71regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.36114953
72regulation of gamma-delta T cell differentiation (GO:0045586)3.34018626
73negative regulation of interleukin-1 production (GO:0032692)3.32555429
74negative regulation of type 2 immune response (GO:0002829)3.31459315
75negative regulation of toll-like receptor signaling pathway (GO:0034122)3.26454875
76positive regulation of toll-like receptor signaling pathway (GO:0034123)3.23735300
77positive regulation of cellular amide metabolic process (GO:0034250)3.22458275
78regulation of dendritic cell antigen processing and presentation (GO:0002604)3.20422400
79myeloid leukocyte mediated immunity (GO:0002444)3.20143625
80negative regulation of interleukin-6 production (GO:0032715)3.16431547
81negative regulation of interleukin-1 beta production (GO:0032691)3.16301915
82T-helper 1 type immune response (GO:0042088)3.15364517
83negative regulation of erythrocyte differentiation (GO:0045647)3.14774422
84negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.10035987
85negative regulation of cytokine production involved in immune response (GO:0002719)3.09050255
86negative regulation of alpha-beta T cell activation (GO:0046636)3.08088570
87regulation of regulated secretory pathway (GO:1903305)3.06772853
88response to protozoan (GO:0001562)3.05290511
89negative regulation of phagocytosis (GO:0050765)3.03908909
90regulation of tolerance induction (GO:0002643)3.03856723
91myeloid leukocyte activation (GO:0002274)3.03309789
92regulation of B cell differentiation (GO:0045577)2.99408396
93positive regulation of interferon-alpha production (GO:0032727)2.99381562
94negative regulation of immunoglobulin mediated immune response (GO:0002890)2.94782862
95negative regulation of B cell mediated immunity (GO:0002713)2.94782862
96regulation of interleukin-6 biosynthetic process (GO:0045408)2.93589290
97regulation of toll-like receptor signaling pathway (GO:0034121)2.92072465
98cellular response to interleukin-15 (GO:0071350)2.91175710
99regulation of macrophage cytokine production (GO:0010935)2.91059541
100granulocyte chemotaxis (GO:0071621)2.90658336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.21531983
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.44850104
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.40824380
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.72741467
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.39587227
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.38085221
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.36554694
8SPI1_23547873_ChIP-Seq_NB4_Human3.10208442
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.08440200
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.95494562
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.95277037
12VDR_24763502_ChIP-Seq_THP-1_Human2.76485294
13VDR_21846776_ChIP-Seq_THP-1_Human2.75128414
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.74606604
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.65493810
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.61283167
17SPI1_23127762_ChIP-Seq_K562_Human2.58914709
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.42751220
19RUNX1_22412390_ChIP-Seq_EML_Mouse2.39749210
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.38965425
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.36987991
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.31913018
23MYC_22102868_ChIP-Seq_BL_Human2.27618865
24MAF_26560356_Chip-Seq_TH1_Human2.25991975
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.23902978
26RUNX_20019798_ChIP-Seq_JUKART_Human2.20334792
27MYB_26560356_Chip-Seq_TH2_Human2.09744795
28STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09453585
29UTX_26944678_Chip-Seq_JUKART_Human2.08916274
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.06486792
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.99373719
32SCL_19346495_ChIP-Seq_HPC-7_Human1.98348159
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.93647494
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93047414
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.92690528
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.92690528
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.92690528
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90658554
39MYB_26560356_Chip-Seq_TH1_Human1.89879412
40TCF7_22412390_ChIP-Seq_EML_Mouse1.87384113
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.82462809
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.80681417
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80637782
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77406693
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74982932
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.73009420
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.71578475
48MAF_26560356_Chip-Seq_TH2_Human1.70848070
49VDR_24787735_ChIP-Seq_THP-1_Human1.68005924
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63158438
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.58613971
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57507075
53KDM2B_26808549_Chip-Seq_DND41_Human1.57504176
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57330916
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54381207
56PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53267698
57PU_27001747_Chip-Seq_BMDM_Mouse1.50788829
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49869556
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47661879
60GATA3_27048872_Chip-Seq_THYMUS_Human1.46931522
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41332248
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39492713
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38924075
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38374787
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32959132
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32113359
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31733857
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.31698190
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31007619
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28392054
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27889603
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.27238345
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26482952
74GATA3_26560356_Chip-Seq_TH2_Human1.22021891
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18870486
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18213388
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17204298
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17120936
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12101526
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11985488
81ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08150955
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.03197522
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02213368
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99032990
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93720167
86SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93092894
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92910348
88LXR_22292898_ChIP-Seq_THP-1_Human0.90781794
89BCL6_27268052_Chip-Seq_Bcells_Human0.90489009
90RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90250033
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87366020
92BCOR_27268052_Chip-Seq_Bcells_Human0.87106709
93NCOR1_26117541_ChIP-Seq_K562_Human0.85388579
94TFEB_21752829_ChIP-Seq_HELA_Human0.84822982
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82959308
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82462581
97EGR1_19032775_ChIP-ChIP_M12_Human0.78190031
98SPI1_20517297_ChIP-Seq_HL60_Human0.78070512
99SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.76792936
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.76753496

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.43935136
2MP0003303_peritoneal_inflammation4.59734222
3MP0003436_decreased_susceptibility_to4.41987012
4MP0002419_abnormal_innate_immunity3.36028187
5MP0001835_abnormal_antigen_presentation3.34567032
6MP0005025_abnormal_response_to2.76358849
7MP0005000_abnormal_immune_tolerance2.68491362
8MP0001800_abnormal_humoral_immune2.65980487
9MP0005671_abnormal_response_to2.62132652
10MP0009785_altered_susceptibility_to2.61174315
11MP0000685_abnormal_immune_system2.59226845
12MP0006082_CNS_inflammation2.58431110
13MP0005387_immune_system_phenotype2.56657660
14MP0001790_abnormal_immune_system2.56657660
15MP0009278_abnormal_bone_marrow2.55782809
16MP0002723_abnormal_immune_serum2.49158284
17MP0002452_abnormal_antigen_presenting2.46800259
18MP0002420_abnormal_adaptive_immunity2.43423783
19MP0001819_abnormal_immune_cell2.41360972
20MP0008260_abnormal_autophagy2.39185193
21MP0001533_abnormal_skeleton_physiology2.36341658
22MP0002148_abnormal_hypersensitivity_rea2.35407918
23MP0003191_abnormal_cellular_cholesterol2.17012544
24MP0003300_gastrointestinal_ulcer2.05700533
25MP0002132_abnormal_respiratory_system2.02774901
26MP0003828_pulmonary_edema2.00021882
27MP0002405_respiratory_system_inflammati1.97462490
28MP0009764_decreased_sensitivity_to1.91140561
29MP0005464_abnormal_platelet_physiology1.86740215
30MP0002277_abnormal_respiratory_mucosa1.80542316
31MP0002398_abnormal_bone_marrow1.79707129
32MP0000716_abnormal_immune_system1.78092514
33MP0008004_abnormal_stomach_pH1.75352659
34MP0004510_myositis1.69528571
35MP0001845_abnormal_inflammatory_respons1.69141644
36MP0003172_abnormal_lysosome_physiology1.68039568
37MP0002396_abnormal_hematopoietic_system1.66997920
38MP0010155_abnormal_intestine_physiology1.64817959
39MP0004947_skin_inflammation1.63342157
40MP0003763_abnormal_thymus_physiology1.58674501
41MP0003075_altered_response_to1.57444420
42MP0000858_altered_metastatic_potential1.53780008
43MP0001545_abnormal_hematopoietic_system1.50158831
44MP0005397_hematopoietic_system_phenotyp1.50158831
45MP0000465_gastrointestinal_hemorrhage1.50021628
46MP0002722_abnormal_immune_system1.46013813
47MP0002998_abnormal_bone_remodeling1.45454849
48MP0005451_abnormal_body_composition1.44129464
49MP0002254_reproductive_system_inflammat1.43630969
50MP0000689_abnormal_spleen_morphology1.43016417
51MP0008469_abnormal_protein_level1.41426658
52MP0002429_abnormal_blood_cell1.41370026
53MP0005310_abnormal_salivary_gland1.39484935
54MP0009333_abnormal_splenocyte_physiolog1.27168897
55MP0004883_abnormal_blood_vessel1.23827166
56MP0000703_abnormal_thymus_morphology1.23802431
57MP0003866_abnormal_defecation1.15971349
58MP0001853_heart_inflammation1.13703225
59MP0001851_eye_inflammation1.13274669
60MP0003448_altered_tumor_morphology1.11646910
61MP0005166_decreased_susceptibility_to1.08972133
62MP0004381_abnormal_hair_follicle1.07825986
63MP0000343_altered_response_to1.07640705
64MP0003690_abnormal_glial_cell1.00400341
65MP0003221_abnormal_cardiomyocyte_apopto1.00221989
66MP0005164_abnormal_response_to0.99025844
67MP0003878_abnormal_ear_physiology0.97282924
68MP0005377_hearing/vestibular/ear_phenot0.97282924
69MP0005058_abnormal_lysosome_morphology0.97140545
70MP0004808_abnormal_hematopoietic_stem0.95528059
71MP0005390_skeleton_phenotype0.93339838
72MP0002332_abnormal_exercise_endurance0.89633654
73MP0001663_abnormal_digestive_system0.84306695
74MP0009763_increased_sensitivity_to0.83023245
75MP0009765_abnormal_xenobiotic_induced0.82953518
76MP0000490_abnormal_crypts_of0.76446284
77MP0003183_abnormal_peptide_metabolism0.75353187
78MP0005167_abnormal_blood-brain_barrier0.72041747
79MP0005076_abnormal_cell_differentiation0.71966252
80MP0003705_abnormal_hypodermis_morpholog0.69360551
81MP0003806_abnormal_nucleotide_metabolis0.66815276
82MP0005319_abnormal_enzyme/_coenzyme0.64534914
83MP0001986_abnormal_taste_sensitivity0.63543541
84MP0002138_abnormal_hepatobiliary_system0.62220863
85MP0002133_abnormal_respiratory_system0.61880391
86MP0005388_respiratory_system_phenotype0.61880391
87MP0003646_muscle_fatigue0.61106040
88MP0003795_abnormal_bone_structure0.60742636
89MP0008874_decreased_physiological_sensi0.59491332
90MP0003656_abnormal_erythrocyte_physiolo0.59223438
91MP0002166_altered_tumor_susceptibility0.58361688
92MP0000604_amyloidosis0.57808259
93MP0005075_abnormal_melanosome_morpholog0.55415903
94MP0006035_abnormal_mitochondrial_morpho0.52589985
95MP0000470_abnormal_stomach_morphology0.51697127
96MP0000750_abnormal_muscle_regeneration0.50454035
97MP0003453_abnormal_keratinocyte_physiol0.50198043
98MP0010352_gastrointestinal_tract_polyps0.49099274
99MP0001915_intracranial_hemorrhage0.48702563
100MP0003566_abnormal_cell_adhesion0.47490657

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.50845621
2Myositis (HP:0100614)6.34170572
3Orchitis (HP:0100796)6.32331200
4Recurrent bacterial skin infections (HP:0005406)6.30657033
5Recurrent abscess formation (HP:0002722)6.25527074
6Retrobulbar optic neuritis (HP:0100654)6.15084067
7Optic neuritis (HP:0100653)6.15084067
8Abnormality of macrophages (HP:0004311)5.69819020
9Stomatitis (HP:0010280)5.18988370
10Recurrent gram-negative bacterial infections (HP:0005420)5.07373528
11Elevated erythrocyte sedimentation rate (HP:0003565)4.72036045
12Gastrointestinal infarctions (HP:0005244)4.54496660
13Keratoconjunctivitis sicca (HP:0001097)4.42396284
14Spontaneous hematomas (HP:0007420)4.39874389
15Recurrent skin infections (HP:0001581)4.32809671
16Abnormal delayed hypersensitivity skin test (HP:0002963)4.29739811
17Recurrent fungal infections (HP:0002841)4.17350653
18Recurrent cutaneous fungal infections (HP:0011370)4.14785459
19Chronic mucocutaneous candidiasis (HP:0002728)4.14785459
20Encephalitis (HP:0002383)4.11572092
21Mediastinal lymphadenopathy (HP:0100721)4.09803476
22Meningitis (HP:0001287)4.06301801
23Keratoconjunctivitis (HP:0001096)4.04206629
24Chronic obstructive pulmonary disease (HP:0006510)3.97018816
25Obstructive lung disease (HP:0006536)3.97018816
26Vasculitis (HP:0002633)3.50833528
27Peritonitis (HP:0002586)3.49103283
28Increased IgE level (HP:0003212)3.46491417
29Urticaria (HP:0001025)3.45236282
30Hemoptysis (HP:0002105)3.42447170
31Episodic fever (HP:0001954)3.40684047
32Gingivitis (HP:0000230)3.37580793
33Amyloidosis (HP:0011034)3.34148774
34Anorexia (HP:0002039)3.23650880
35Chest pain (HP:0100749)3.21937325
36Arterial thrombosis (HP:0004420)2.98293602
37Prolonged bleeding time (HP:0003010)2.91173637
38Pulmonary embolism (HP:0002204)2.88124006
39Pulmonary infiltrates (HP:0002113)2.84881937
40Leukocytosis (HP:0001974)2.83256049
41Cellulitis (HP:0100658)2.77849187
42Increased IgM level (HP:0003496)2.77594089
43Inflammation of the large intestine (HP:0002037)2.71553046
44Gangrene (HP:0100758)2.68571127
45Abnormality of the peritoneum (HP:0002585)2.64882427
46Gastrointestinal inflammation (HP:0004386)2.60224649
47Segmental peripheral demyelination/remyelination (HP:0003481)2.60058650
48T lymphocytopenia (HP:0005403)2.59107846
49Panhypogammaglobulinemia (HP:0003139)2.57882419
50Premature loss of primary teeth (HP:0006323)2.57103111
51Abnormality of T cell number (HP:0011839)2.55347306
52Gingival bleeding (HP:0000225)2.49756265
53Epistaxis (HP:0000421)2.47639838
54Recurrent viral infections (HP:0004429)2.46017066
55Abnormality of the endocardium (HP:0004306)2.43665721
56Pustule (HP:0200039)2.43633996
57Abnormality of the pleura (HP:0002103)2.36877980
58Abnormality of T cells (HP:0002843)2.36735506
59Hypochromic anemia (HP:0001931)2.36036981
60Keratitis (HP:0000491)2.32986792
61Hepatosplenomegaly (HP:0001433)2.32146800
62Osteomyelitis (HP:0002754)2.26113067
63Glomerulopathy (HP:0100820)2.20086497
64Increased cerebral lipofuscin (HP:0011813)2.16834027
65Colitis (HP:0002583)2.16522074
66Loss of speech (HP:0002371)2.15019390
67Petechiae (HP:0000967)2.14903290
68Abnormality of T cell physiology (HP:0011840)2.14317535
69Hypochromic microcytic anemia (HP:0004840)2.11998557
70Polyneuropathy (HP:0001271)2.11704929
71Granulocytopenia (HP:0001913)2.10926502
72Sepsis (HP:0100806)2.10786349
73Metaphyseal cupping (HP:0003021)2.08635632
74Lymphopenia (HP:0001888)2.07566293
75Microcytic anemia (HP:0001935)2.05784906
76Disinhibition (HP:0000734)2.03265442
77Viral hepatitis (HP:0006562)1.99859313
78Vertigo (HP:0002321)1.99194667
79Hypergammaglobulinemia (HP:0010702)1.95830865
80Abnormality of cells of the lymphoid lineage (HP:0012140)1.95615706
81Thrombophlebitis (HP:0004418)1.94267937
82Acute hepatic failure (HP:0006554)1.91757480
83Skin ulcer (HP:0200042)1.89318598
84Acne (HP:0001061)1.89016219
85Amaurosis fugax (HP:0100576)1.85710064
86Increased serum ferritin (HP:0003281)1.82839128
87Hematochezia (HP:0002573)1.81111745
88Agnosia (HP:0010524)1.79050820
89Slow saccadic eye movements (HP:0000514)1.78487861
90Abnormal platelet volume (HP:0011876)1.78297130
91Autoimmune thrombocytopenia (HP:0001973)1.78258508
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.78022564
93Progressive external ophthalmoplegia (HP:0000590)1.77646046
94Abnormality of the pericardium (HP:0001697)1.77383745
95Purpura (HP:0000979)1.77024130
96Increased neuronal autofluorescent lipopigment (HP:0002074)1.76918046
97Recurrent lower respiratory tract infections (HP:0002783)1.75953707
98Respiratory difficulties (HP:0002880)1.75506087
99Skin rash (HP:0000988)1.74833641
100Hypermelanotic macule (HP:0001034)1.74434837

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.04543114
2IRAK43.95096673
3BLK3.30057847
4MAP4K13.19972962
5MAP2K33.08908296
6CSK2.82846883
7TYK22.78397818
8ERN12.66393268
9EPHB12.34041542
10FES2.20608465
11TNK22.15439433
12ZAP702.14367501
13PRPF4B2.08630524
14TAOK12.06880126
15FGR2.05902292
16IRAK11.97535056
17MAP3K141.90442480
18GRK61.88356763
19MAP3K111.77695528
20IRAK21.75736814
21JAK31.71775509
22TXK1.70952691
23MAP3K31.63450915
24HCK1.63084998
25TESK21.61059704
26CDK191.60959855
27YES11.56023410
28JAK21.50599884
29IKBKE1.49522626
30BTK1.47365946
31MATK1.42746667
32SYK1.30533027
33KSR21.28759256
34MAP3K11.27523449
35LYN1.26879679
36MAP3K61.23837471
37TBK11.22114880
38SIK31.09466554
39MAP3K131.06553042
40KIT1.02457040
41LCK1.02042064
42TAOK20.98207161
43CSF1R0.94064240
44GRK70.93477687
45NLK0.91783931
46STK100.88284321
47MARK30.88244366
48PTK60.86607085
49ALK0.86374217
50MARK20.81055698
51MAP3K50.80731995
52IKBKB0.80083334
53JAK10.79951681
54STK240.78009302
55MAP2K40.72986424
56ACVR1B0.70912620
57TAOK30.68904654
58DYRK30.67737612
59ITK0.67213821
60CDC42BPA0.67192404
61TGFBR20.65925145
62TEC0.65198793
63SMG10.63832003
64STK110.63689133
65PRKD20.63035627
66WNK10.62258542
67PDK10.62210533
68MAP3K20.58763699
69BMPR20.58638963
70PDPK10.57935668
71FYN0.57704520
72IRAK30.56699062
73MAPK70.53325934
74MAP3K70.52620260
75DAPK20.48718586
76DYRK1B0.48648003
77RPS6KL10.47794198
78RPS6KC10.47794198
79SIK20.46891402
80PRKG20.46306525
81PIK3CG0.45540985
82SGK30.43586212
83MAPK120.41894667
84RPS6KA10.39827805
85RPS6KA60.39235372
86SIK10.36389957
87CDK40.36183785
88SGK20.36139675
89PIM10.35661504
90PASK0.35536823
91BRD40.33941206
92PAK40.33228974
93PRKCQ0.32954780
94CAMK1D0.32450385
95MAPKAPK20.32346024
96LRRK20.32309610
97FGFR30.32176740
98MAP3K80.31741072
99FGFR40.31721243
100MAP2K20.31402750

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043803.39957136
2Leishmaniasis_Homo sapiens_hsa051403.29197549
3Staphylococcus aureus infection_Homo sapiens_hsa051503.06530420
4Tuberculosis_Homo sapiens_hsa051522.54160061
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.51443401
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.28328162
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.23246373
8B cell receptor signaling pathway_Homo sapiens_hsa046622.20026640
9Legionellosis_Homo sapiens_hsa051342.19790649
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.03496928
11Malaria_Homo sapiens_hsa051442.01259259
12Graft-versus-host disease_Homo sapiens_hsa053321.97503353
13Allograft rejection_Homo sapiens_hsa053301.89675483
14Chemokine signaling pathway_Homo sapiens_hsa040621.85099882
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83481076
16Acute myeloid leukemia_Homo sapiens_hsa052211.81867645
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.79591118
18Hematopoietic cell lineage_Homo sapiens_hsa046401.78099298
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76581700
20Autoimmune thyroid disease_Homo sapiens_hsa053201.72159152
21Primary immunodeficiency_Homo sapiens_hsa053401.67490817
22Influenza A_Homo sapiens_hsa051641.65814096
23Measles_Homo sapiens_hsa051621.64508919
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63062198
25TNF signaling pathway_Homo sapiens_hsa046681.58598073
26Phagosome_Homo sapiens_hsa041451.54256535
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.53054424
28Toxoplasmosis_Homo sapiens_hsa051451.51804668
29Type I diabetes mellitus_Homo sapiens_hsa049401.36775816
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.36240680
31Herpes simplex infection_Homo sapiens_hsa051681.35952255
32Antigen processing and presentation_Homo sapiens_hsa046121.35289621
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.34342566
34T cell receptor signaling pathway_Homo sapiens_hsa046601.33726674
35Viral myocarditis_Homo sapiens_hsa054161.32611650
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28511838
37Hepatitis B_Homo sapiens_hsa051611.26832058
38Rheumatoid arthritis_Homo sapiens_hsa053231.22022291
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.21741261
40Salmonella infection_Homo sapiens_hsa051321.19658404
41Pertussis_Homo sapiens_hsa051331.19146997
42African trypanosomiasis_Homo sapiens_hsa051431.17900209
43Shigellosis_Homo sapiens_hsa051311.14478175
44Hepatitis C_Homo sapiens_hsa051601.09306033
45Notch signaling pathway_Homo sapiens_hsa043301.05868325
46Non-small cell lung cancer_Homo sapiens_hsa052231.05271114
47Chronic myeloid leukemia_Homo sapiens_hsa052201.03309327
48Renal cell carcinoma_Homo sapiens_hsa052111.01408268
49Platelet activation_Homo sapiens_hsa046110.98838590
50Apoptosis_Homo sapiens_hsa042100.97128232
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93936617
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93171964
53Pancreatic cancer_Homo sapiens_hsa052120.92196682
54Lysosome_Homo sapiens_hsa041420.91640936
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91391038
56Epstein-Barr virus infection_Homo sapiens_hsa051690.90161908
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88316446
58Other glycan degradation_Homo sapiens_hsa005110.87905678
59Asthma_Homo sapiens_hsa053100.87600397
60Regulation of autophagy_Homo sapiens_hsa041400.86164953
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.85172893
62Prolactin signaling pathway_Homo sapiens_hsa049170.84491441
63VEGF signaling pathway_Homo sapiens_hsa043700.80381608
64Amoebiasis_Homo sapiens_hsa051460.78860497
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76457965
66Endocytosis_Homo sapiens_hsa041440.75442495
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.71417380
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.69282215
69FoxO signaling pathway_Homo sapiens_hsa040680.68570302
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67743310
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65703420
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64576475
73Dorso-ventral axis formation_Homo sapiens_hsa043200.63552395
74HIF-1 signaling pathway_Homo sapiens_hsa040660.62618001
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.62275976
76Colorectal cancer_Homo sapiens_hsa052100.61136447
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59738072
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.59084477
79HTLV-I infection_Homo sapiens_hsa051660.57840183
80Viral carcinogenesis_Homo sapiens_hsa052030.55882545
81Type II diabetes mellitus_Homo sapiens_hsa049300.55757621
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54448966
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54257261
84Endometrial cancer_Homo sapiens_hsa052130.54023793
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52151621
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49614173
87Rap1 signaling pathway_Homo sapiens_hsa040150.49353961
88GnRH signaling pathway_Homo sapiens_hsa049120.49055785
89Bladder cancer_Homo sapiens_hsa052190.48623066
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.48029743
91Choline metabolism in cancer_Homo sapiens_hsa052310.47059608
92Collecting duct acid secretion_Homo sapiens_hsa049660.46913912
93MAPK signaling pathway_Homo sapiens_hsa040100.44184959
94Inositol phosphate metabolism_Homo sapiens_hsa005620.44048648
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43071696
96Prostate cancer_Homo sapiens_hsa052150.42618153
97Insulin resistance_Homo sapiens_hsa049310.41728876
98mTOR signaling pathway_Homo sapiens_hsa041500.40900441
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40374049
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.38560045

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