Rank | Gene Set | Z-score |
---|---|---|
1 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 6.68260807 |
2 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 6.68260807 |
3 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 6.68260807 |
4 | modulation by symbiont of host immune response (GO:0052553) | 6.68260807 |
5 | positive regulation by symbiont of host defense response (GO:0052509) | 6.68260807 |
6 | modulation by symbiont of host defense response (GO:0052031) | 6.68260807 |
7 | neutrophil activation involved in immune response (GO:0002283) | 6.22814152 |
8 | response to peptidoglycan (GO:0032494) | 5.79978470 |
9 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 5.79268508 |
10 | negative regulation of cell killing (GO:0031342) | 5.79268508 |
11 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 5.76865114 |
12 | cellular extravasation (GO:0045123) | 5.63182743 |
13 | detection of molecule of bacterial origin (GO:0032490) | 5.49864416 |
14 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.44102577 |
15 | negative regulation of interleukin-12 production (GO:0032695) | 5.39421145 |
16 | detection of other organism (GO:0098543) | 5.32871288 |
17 | macrophage activation involved in immune response (GO:0002281) | 5.28757906 |
18 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.25870174 |
19 | neutrophil activation (GO:0042119) | 5.03633099 |
20 | detection of external biotic stimulus (GO:0098581) | 4.85632276 |
21 | detection of bacterium (GO:0016045) | 4.82314576 |
22 | respiratory burst (GO:0045730) | 4.81567140 |
23 | granulocyte activation (GO:0036230) | 4.63903493 |
24 | regulation of interferon-beta biosynthetic process (GO:0045357) | 4.54776361 |
25 | leukocyte migration involved in inflammatory response (GO:0002523) | 4.53502371 |
26 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.52261815 |
27 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.37027361 |
28 | detection of biotic stimulus (GO:0009595) | 4.28830675 |
29 | response to muramyl dipeptide (GO:0032495) | 4.28819138 |
30 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.28537205 |
31 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 4.27168534 |
32 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 4.26384104 |
33 | response to host immune response (GO:0052572) | 4.26384104 |
34 | regulation of gamma-delta T cell activation (GO:0046643) | 4.12640859 |
35 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 4.10025700 |
36 | regulation of mast cell degranulation (GO:0043304) | 4.06431325 |
37 | macrophage activation (GO:0042116) | 4.03807443 |
38 | leukocyte aggregation (GO:0070486) | 4.02455409 |
39 | immunoglobulin mediated immune response (GO:0016064) | 3.99400745 |
40 | myeloid cell activation involved in immune response (GO:0002275) | 3.98423734 |
41 | microglial cell activation (GO:0001774) | 3.98190446 |
42 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.95802717 |
43 | regulation of nitric-oxide synthase biosynthetic process (GO:0051769) | 3.93507987 |
44 | neutrophil mediated immunity (GO:0002446) | 3.93233871 |
45 | germinal center formation (GO:0002467) | 3.86386551 |
46 | regulation of T-helper 2 cell differentiation (GO:0045628) | 3.84859458 |
47 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.84683450 |
48 | response to host (GO:0075136) | 3.84683450 |
49 | response to host defenses (GO:0052200) | 3.84683450 |
50 | positive regulation of mast cell activation (GO:0033005) | 3.81036682 |
51 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.77156977 |
52 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 3.72384926 |
53 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.71174994 |
54 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.67028440 |
55 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.66059274 |
56 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 3.61199650 |
57 | negative regulation of T-helper cell differentiation (GO:0045623) | 3.61199650 |
58 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 3.60410366 |
59 | regulation of mast cell activation (GO:0033003) | 3.53915621 |
60 | leukocyte degranulation (GO:0043299) | 3.52648219 |
61 | neutrophil chemotaxis (GO:0030593) | 3.50947273 |
62 | regulation of leukocyte degranulation (GO:0043300) | 3.50473257 |
63 | defense response to protozoan (GO:0042832) | 3.47679042 |
64 | positive regulation of mast cell degranulation (GO:0043306) | 3.42475456 |
65 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.42475456 |
66 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 3.42085615 |
67 | neutrophil migration (GO:1990266) | 3.41902356 |
68 | negative regulation of T cell mediated immunity (GO:0002710) | 3.40623208 |
69 | B cell mediated immunity (GO:0019724) | 3.40035372 |
70 | response to interleukin-15 (GO:0070672) | 3.38895472 |
71 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 3.36114953 |
72 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.34018626 |
73 | negative regulation of interleukin-1 production (GO:0032692) | 3.32555429 |
74 | negative regulation of type 2 immune response (GO:0002829) | 3.31459315 |
75 | negative regulation of toll-like receptor signaling pathway (GO:0034122) | 3.26454875 |
76 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 3.23735300 |
77 | positive regulation of cellular amide metabolic process (GO:0034250) | 3.22458275 |
78 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.20422400 |
79 | myeloid leukocyte mediated immunity (GO:0002444) | 3.20143625 |
80 | negative regulation of interleukin-6 production (GO:0032715) | 3.16431547 |
81 | negative regulation of interleukin-1 beta production (GO:0032691) | 3.16301915 |
82 | T-helper 1 type immune response (GO:0042088) | 3.15364517 |
83 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.14774422 |
84 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 3.10035987 |
85 | negative regulation of cytokine production involved in immune response (GO:0002719) | 3.09050255 |
86 | negative regulation of alpha-beta T cell activation (GO:0046636) | 3.08088570 |
87 | regulation of regulated secretory pathway (GO:1903305) | 3.06772853 |
88 | response to protozoan (GO:0001562) | 3.05290511 |
89 | negative regulation of phagocytosis (GO:0050765) | 3.03908909 |
90 | regulation of tolerance induction (GO:0002643) | 3.03856723 |
91 | myeloid leukocyte activation (GO:0002274) | 3.03309789 |
92 | regulation of B cell differentiation (GO:0045577) | 2.99408396 |
93 | positive regulation of interferon-alpha production (GO:0032727) | 2.99381562 |
94 | negative regulation of immunoglobulin mediated immune response (GO:0002890) | 2.94782862 |
95 | negative regulation of B cell mediated immunity (GO:0002713) | 2.94782862 |
96 | regulation of interleukin-6 biosynthetic process (GO:0045408) | 2.93589290 |
97 | regulation of toll-like receptor signaling pathway (GO:0034121) | 2.92072465 |
98 | cellular response to interleukin-15 (GO:0071350) | 2.91175710 |
99 | regulation of macrophage cytokine production (GO:0010935) | 2.91059541 |
100 | granulocyte chemotaxis (GO:0071621) | 2.90658336 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 5.21531983 |
2 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.44850104 |
3 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.40824380 |
4 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.72741467 |
5 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.39587227 |
6 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.38085221 |
7 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 3.36554694 |
8 | SPI1_23547873_ChIP-Seq_NB4_Human | 3.10208442 |
9 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 3.08440200 |
10 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.95494562 |
11 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.95277037 |
12 | VDR_24763502_ChIP-Seq_THP-1_Human | 2.76485294 |
13 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.75128414 |
14 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.74606604 |
15 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.65493810 |
16 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.61283167 |
17 | SPI1_23127762_ChIP-Seq_K562_Human | 2.58914709 |
18 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.42751220 |
19 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 2.39749210 |
20 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.38965425 |
21 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.36987991 |
22 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.31913018 |
23 | MYC_22102868_ChIP-Seq_BL_Human | 2.27618865 |
24 | MAF_26560356_Chip-Seq_TH1_Human | 2.25991975 |
25 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.23902978 |
26 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.20334792 |
27 | MYB_26560356_Chip-Seq_TH2_Human | 2.09744795 |
28 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.09453585 |
29 | UTX_26944678_Chip-Seq_JUKART_Human | 2.08916274 |
30 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 2.06486792 |
31 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.99373719 |
32 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.98348159 |
33 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.93647494 |
34 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.93047414 |
35 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.92690528 |
36 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.92690528 |
37 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.92690528 |
38 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.90658554 |
39 | MYB_26560356_Chip-Seq_TH1_Human | 1.89879412 |
40 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.87384113 |
41 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.82462809 |
42 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.80681417 |
43 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.80637782 |
44 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.77406693 |
45 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.74982932 |
46 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.73009420 |
47 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.71578475 |
48 | MAF_26560356_Chip-Seq_TH2_Human | 1.70848070 |
49 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.68005924 |
50 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.63158438 |
51 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.58613971 |
52 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.57507075 |
53 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.57504176 |
54 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.57330916 |
55 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.54381207 |
56 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.53267698 |
57 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.50788829 |
58 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.49869556 |
59 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.47661879 |
60 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.46931522 |
61 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.41332248 |
62 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.39492713 |
63 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.38924075 |
64 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.38374787 |
65 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.32959132 |
66 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.32113359 |
67 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.31733857 |
68 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.31698190 |
69 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.31007619 |
70 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.28392054 |
71 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.27889603 |
72 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.27238345 |
73 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.26482952 |
74 | GATA3_26560356_Chip-Seq_TH2_Human | 1.22021891 |
75 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.18870486 |
76 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.18213388 |
77 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.17204298 |
78 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.17120936 |
79 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.12101526 |
80 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.11985488 |
81 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.08150955 |
82 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.03197522 |
83 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.02213368 |
84 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.99032990 |
85 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.93720167 |
86 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.93092894 |
87 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.92910348 |
88 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.90781794 |
89 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.90489009 |
90 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.90250033 |
91 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.87366020 |
92 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.87106709 |
93 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.85388579 |
94 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.84822982 |
95 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.82959308 |
96 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.82462581 |
97 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.78190031 |
98 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.78070512 |
99 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.76792936 |
100 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.76753496 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003724_increased_susceptibility_to | 5.43935136 |
2 | MP0003303_peritoneal_inflammation | 4.59734222 |
3 | MP0003436_decreased_susceptibility_to | 4.41987012 |
4 | MP0002419_abnormal_innate_immunity | 3.36028187 |
5 | MP0001835_abnormal_antigen_presentation | 3.34567032 |
6 | MP0005025_abnormal_response_to | 2.76358849 |
7 | MP0005000_abnormal_immune_tolerance | 2.68491362 |
8 | MP0001800_abnormal_humoral_immune | 2.65980487 |
9 | MP0005671_abnormal_response_to | 2.62132652 |
10 | MP0009785_altered_susceptibility_to | 2.61174315 |
11 | MP0000685_abnormal_immune_system | 2.59226845 |
12 | MP0006082_CNS_inflammation | 2.58431110 |
13 | MP0005387_immune_system_phenotype | 2.56657660 |
14 | MP0001790_abnormal_immune_system | 2.56657660 |
15 | MP0009278_abnormal_bone_marrow | 2.55782809 |
16 | MP0002723_abnormal_immune_serum | 2.49158284 |
17 | MP0002452_abnormal_antigen_presenting | 2.46800259 |
18 | MP0002420_abnormal_adaptive_immunity | 2.43423783 |
19 | MP0001819_abnormal_immune_cell | 2.41360972 |
20 | MP0008260_abnormal_autophagy | 2.39185193 |
21 | MP0001533_abnormal_skeleton_physiology | 2.36341658 |
22 | MP0002148_abnormal_hypersensitivity_rea | 2.35407918 |
23 | MP0003191_abnormal_cellular_cholesterol | 2.17012544 |
24 | MP0003300_gastrointestinal_ulcer | 2.05700533 |
25 | MP0002132_abnormal_respiratory_system | 2.02774901 |
26 | MP0003828_pulmonary_edema | 2.00021882 |
27 | MP0002405_respiratory_system_inflammati | 1.97462490 |
28 | MP0009764_decreased_sensitivity_to | 1.91140561 |
29 | MP0005464_abnormal_platelet_physiology | 1.86740215 |
30 | MP0002277_abnormal_respiratory_mucosa | 1.80542316 |
31 | MP0002398_abnormal_bone_marrow | 1.79707129 |
32 | MP0000716_abnormal_immune_system | 1.78092514 |
33 | MP0008004_abnormal_stomach_pH | 1.75352659 |
34 | MP0004510_myositis | 1.69528571 |
35 | MP0001845_abnormal_inflammatory_respons | 1.69141644 |
36 | MP0003172_abnormal_lysosome_physiology | 1.68039568 |
37 | MP0002396_abnormal_hematopoietic_system | 1.66997920 |
38 | MP0010155_abnormal_intestine_physiology | 1.64817959 |
39 | MP0004947_skin_inflammation | 1.63342157 |
40 | MP0003763_abnormal_thymus_physiology | 1.58674501 |
41 | MP0003075_altered_response_to | 1.57444420 |
42 | MP0000858_altered_metastatic_potential | 1.53780008 |
43 | MP0001545_abnormal_hematopoietic_system | 1.50158831 |
44 | MP0005397_hematopoietic_system_phenotyp | 1.50158831 |
45 | MP0000465_gastrointestinal_hemorrhage | 1.50021628 |
46 | MP0002722_abnormal_immune_system | 1.46013813 |
47 | MP0002998_abnormal_bone_remodeling | 1.45454849 |
48 | MP0005451_abnormal_body_composition | 1.44129464 |
49 | MP0002254_reproductive_system_inflammat | 1.43630969 |
50 | MP0000689_abnormal_spleen_morphology | 1.43016417 |
51 | MP0008469_abnormal_protein_level | 1.41426658 |
52 | MP0002429_abnormal_blood_cell | 1.41370026 |
53 | MP0005310_abnormal_salivary_gland | 1.39484935 |
54 | MP0009333_abnormal_splenocyte_physiolog | 1.27168897 |
55 | MP0004883_abnormal_blood_vessel | 1.23827166 |
56 | MP0000703_abnormal_thymus_morphology | 1.23802431 |
57 | MP0003866_abnormal_defecation | 1.15971349 |
58 | MP0001853_heart_inflammation | 1.13703225 |
59 | MP0001851_eye_inflammation | 1.13274669 |
60 | MP0003448_altered_tumor_morphology | 1.11646910 |
61 | MP0005166_decreased_susceptibility_to | 1.08972133 |
62 | MP0004381_abnormal_hair_follicle | 1.07825986 |
63 | MP0000343_altered_response_to | 1.07640705 |
64 | MP0003690_abnormal_glial_cell | 1.00400341 |
65 | MP0003221_abnormal_cardiomyocyte_apopto | 1.00221989 |
66 | MP0005164_abnormal_response_to | 0.99025844 |
67 | MP0003878_abnormal_ear_physiology | 0.97282924 |
68 | MP0005377_hearing/vestibular/ear_phenot | 0.97282924 |
69 | MP0005058_abnormal_lysosome_morphology | 0.97140545 |
70 | MP0004808_abnormal_hematopoietic_stem | 0.95528059 |
71 | MP0005390_skeleton_phenotype | 0.93339838 |
72 | MP0002332_abnormal_exercise_endurance | 0.89633654 |
73 | MP0001663_abnormal_digestive_system | 0.84306695 |
74 | MP0009763_increased_sensitivity_to | 0.83023245 |
75 | MP0009765_abnormal_xenobiotic_induced | 0.82953518 |
76 | MP0000490_abnormal_crypts_of | 0.76446284 |
77 | MP0003183_abnormal_peptide_metabolism | 0.75353187 |
78 | MP0005167_abnormal_blood-brain_barrier | 0.72041747 |
79 | MP0005076_abnormal_cell_differentiation | 0.71966252 |
80 | MP0003705_abnormal_hypodermis_morpholog | 0.69360551 |
81 | MP0003806_abnormal_nucleotide_metabolis | 0.66815276 |
82 | MP0005319_abnormal_enzyme/_coenzyme | 0.64534914 |
83 | MP0001986_abnormal_taste_sensitivity | 0.63543541 |
84 | MP0002138_abnormal_hepatobiliary_system | 0.62220863 |
85 | MP0002133_abnormal_respiratory_system | 0.61880391 |
86 | MP0005388_respiratory_system_phenotype | 0.61880391 |
87 | MP0003646_muscle_fatigue | 0.61106040 |
88 | MP0003795_abnormal_bone_structure | 0.60742636 |
89 | MP0008874_decreased_physiological_sensi | 0.59491332 |
90 | MP0003656_abnormal_erythrocyte_physiolo | 0.59223438 |
91 | MP0002166_altered_tumor_susceptibility | 0.58361688 |
92 | MP0000604_amyloidosis | 0.57808259 |
93 | MP0005075_abnormal_melanosome_morpholog | 0.55415903 |
94 | MP0006035_abnormal_mitochondrial_morpho | 0.52589985 |
95 | MP0000470_abnormal_stomach_morphology | 0.51697127 |
96 | MP0000750_abnormal_muscle_regeneration | 0.50454035 |
97 | MP0003453_abnormal_keratinocyte_physiol | 0.50198043 |
98 | MP0010352_gastrointestinal_tract_polyps | 0.49099274 |
99 | MP0001915_intracranial_hemorrhage | 0.48702563 |
100 | MP0003566_abnormal_cell_adhesion | 0.47490657 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Eczematoid dermatitis (HP:0000976) | 6.50845621 |
2 | Myositis (HP:0100614) | 6.34170572 |
3 | Orchitis (HP:0100796) | 6.32331200 |
4 | Recurrent bacterial skin infections (HP:0005406) | 6.30657033 |
5 | Recurrent abscess formation (HP:0002722) | 6.25527074 |
6 | Retrobulbar optic neuritis (HP:0100654) | 6.15084067 |
7 | Optic neuritis (HP:0100653) | 6.15084067 |
8 | Abnormality of macrophages (HP:0004311) | 5.69819020 |
9 | Stomatitis (HP:0010280) | 5.18988370 |
10 | Recurrent gram-negative bacterial infections (HP:0005420) | 5.07373528 |
11 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.72036045 |
12 | Gastrointestinal infarctions (HP:0005244) | 4.54496660 |
13 | Keratoconjunctivitis sicca (HP:0001097) | 4.42396284 |
14 | Spontaneous hematomas (HP:0007420) | 4.39874389 |
15 | Recurrent skin infections (HP:0001581) | 4.32809671 |
16 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 4.29739811 |
17 | Recurrent fungal infections (HP:0002841) | 4.17350653 |
18 | Recurrent cutaneous fungal infections (HP:0011370) | 4.14785459 |
19 | Chronic mucocutaneous candidiasis (HP:0002728) | 4.14785459 |
20 | Encephalitis (HP:0002383) | 4.11572092 |
21 | Mediastinal lymphadenopathy (HP:0100721) | 4.09803476 |
22 | Meningitis (HP:0001287) | 4.06301801 |
23 | Keratoconjunctivitis (HP:0001096) | 4.04206629 |
24 | Chronic obstructive pulmonary disease (HP:0006510) | 3.97018816 |
25 | Obstructive lung disease (HP:0006536) | 3.97018816 |
26 | Vasculitis (HP:0002633) | 3.50833528 |
27 | Peritonitis (HP:0002586) | 3.49103283 |
28 | Increased IgE level (HP:0003212) | 3.46491417 |
29 | Urticaria (HP:0001025) | 3.45236282 |
30 | Hemoptysis (HP:0002105) | 3.42447170 |
31 | Episodic fever (HP:0001954) | 3.40684047 |
32 | Gingivitis (HP:0000230) | 3.37580793 |
33 | Amyloidosis (HP:0011034) | 3.34148774 |
34 | Anorexia (HP:0002039) | 3.23650880 |
35 | Chest pain (HP:0100749) | 3.21937325 |
36 | Arterial thrombosis (HP:0004420) | 2.98293602 |
37 | Prolonged bleeding time (HP:0003010) | 2.91173637 |
38 | Pulmonary embolism (HP:0002204) | 2.88124006 |
39 | Pulmonary infiltrates (HP:0002113) | 2.84881937 |
40 | Leukocytosis (HP:0001974) | 2.83256049 |
41 | Cellulitis (HP:0100658) | 2.77849187 |
42 | Increased IgM level (HP:0003496) | 2.77594089 |
43 | Inflammation of the large intestine (HP:0002037) | 2.71553046 |
44 | Gangrene (HP:0100758) | 2.68571127 |
45 | Abnormality of the peritoneum (HP:0002585) | 2.64882427 |
46 | Gastrointestinal inflammation (HP:0004386) | 2.60224649 |
47 | Segmental peripheral demyelination/remyelination (HP:0003481) | 2.60058650 |
48 | T lymphocytopenia (HP:0005403) | 2.59107846 |
49 | Panhypogammaglobulinemia (HP:0003139) | 2.57882419 |
50 | Premature loss of primary teeth (HP:0006323) | 2.57103111 |
51 | Abnormality of T cell number (HP:0011839) | 2.55347306 |
52 | Gingival bleeding (HP:0000225) | 2.49756265 |
53 | Epistaxis (HP:0000421) | 2.47639838 |
54 | Recurrent viral infections (HP:0004429) | 2.46017066 |
55 | Abnormality of the endocardium (HP:0004306) | 2.43665721 |
56 | Pustule (HP:0200039) | 2.43633996 |
57 | Abnormality of the pleura (HP:0002103) | 2.36877980 |
58 | Abnormality of T cells (HP:0002843) | 2.36735506 |
59 | Hypochromic anemia (HP:0001931) | 2.36036981 |
60 | Keratitis (HP:0000491) | 2.32986792 |
61 | Hepatosplenomegaly (HP:0001433) | 2.32146800 |
62 | Osteomyelitis (HP:0002754) | 2.26113067 |
63 | Glomerulopathy (HP:0100820) | 2.20086497 |
64 | Increased cerebral lipofuscin (HP:0011813) | 2.16834027 |
65 | Colitis (HP:0002583) | 2.16522074 |
66 | Loss of speech (HP:0002371) | 2.15019390 |
67 | Petechiae (HP:0000967) | 2.14903290 |
68 | Abnormality of T cell physiology (HP:0011840) | 2.14317535 |
69 | Hypochromic microcytic anemia (HP:0004840) | 2.11998557 |
70 | Polyneuropathy (HP:0001271) | 2.11704929 |
71 | Granulocytopenia (HP:0001913) | 2.10926502 |
72 | Sepsis (HP:0100806) | 2.10786349 |
73 | Metaphyseal cupping (HP:0003021) | 2.08635632 |
74 | Lymphopenia (HP:0001888) | 2.07566293 |
75 | Microcytic anemia (HP:0001935) | 2.05784906 |
76 | Disinhibition (HP:0000734) | 2.03265442 |
77 | Viral hepatitis (HP:0006562) | 1.99859313 |
78 | Vertigo (HP:0002321) | 1.99194667 |
79 | Hypergammaglobulinemia (HP:0010702) | 1.95830865 |
80 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 1.95615706 |
81 | Thrombophlebitis (HP:0004418) | 1.94267937 |
82 | Acute hepatic failure (HP:0006554) | 1.91757480 |
83 | Skin ulcer (HP:0200042) | 1.89318598 |
84 | Acne (HP:0001061) | 1.89016219 |
85 | Amaurosis fugax (HP:0100576) | 1.85710064 |
86 | Increased serum ferritin (HP:0003281) | 1.82839128 |
87 | Hematochezia (HP:0002573) | 1.81111745 |
88 | Agnosia (HP:0010524) | 1.79050820 |
89 | Slow saccadic eye movements (HP:0000514) | 1.78487861 |
90 | Abnormal platelet volume (HP:0011876) | 1.78297130 |
91 | Autoimmune thrombocytopenia (HP:0001973) | 1.78258508 |
92 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.78022564 |
93 | Progressive external ophthalmoplegia (HP:0000590) | 1.77646046 |
94 | Abnormality of the pericardium (HP:0001697) | 1.77383745 |
95 | Purpura (HP:0000979) | 1.77024130 |
96 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.76918046 |
97 | Recurrent lower respiratory tract infections (HP:0002783) | 1.75953707 |
98 | Respiratory difficulties (HP:0002880) | 1.75506087 |
99 | Skin rash (HP:0000988) | 1.74833641 |
100 | Hypermelanotic macule (HP:0001034) | 1.74434837 |
Rank | Gene Set | Z-score |
---|---|---|
1 | RIPK4 | 5.04543114 |
2 | IRAK4 | 3.95096673 |
3 | BLK | 3.30057847 |
4 | MAP4K1 | 3.19972962 |
5 | MAP2K3 | 3.08908296 |
6 | CSK | 2.82846883 |
7 | TYK2 | 2.78397818 |
8 | ERN1 | 2.66393268 |
9 | EPHB1 | 2.34041542 |
10 | FES | 2.20608465 |
11 | TNK2 | 2.15439433 |
12 | ZAP70 | 2.14367501 |
13 | PRPF4B | 2.08630524 |
14 | TAOK1 | 2.06880126 |
15 | FGR | 2.05902292 |
16 | IRAK1 | 1.97535056 |
17 | MAP3K14 | 1.90442480 |
18 | GRK6 | 1.88356763 |
19 | MAP3K11 | 1.77695528 |
20 | IRAK2 | 1.75736814 |
21 | JAK3 | 1.71775509 |
22 | TXK | 1.70952691 |
23 | MAP3K3 | 1.63450915 |
24 | HCK | 1.63084998 |
25 | TESK2 | 1.61059704 |
26 | CDK19 | 1.60959855 |
27 | YES1 | 1.56023410 |
28 | JAK2 | 1.50599884 |
29 | IKBKE | 1.49522626 |
30 | BTK | 1.47365946 |
31 | MATK | 1.42746667 |
32 | SYK | 1.30533027 |
33 | KSR2 | 1.28759256 |
34 | MAP3K1 | 1.27523449 |
35 | LYN | 1.26879679 |
36 | MAP3K6 | 1.23837471 |
37 | TBK1 | 1.22114880 |
38 | SIK3 | 1.09466554 |
39 | MAP3K13 | 1.06553042 |
40 | KIT | 1.02457040 |
41 | LCK | 1.02042064 |
42 | TAOK2 | 0.98207161 |
43 | CSF1R | 0.94064240 |
44 | GRK7 | 0.93477687 |
45 | NLK | 0.91783931 |
46 | STK10 | 0.88284321 |
47 | MARK3 | 0.88244366 |
48 | PTK6 | 0.86607085 |
49 | ALK | 0.86374217 |
50 | MARK2 | 0.81055698 |
51 | MAP3K5 | 0.80731995 |
52 | IKBKB | 0.80083334 |
53 | JAK1 | 0.79951681 |
54 | STK24 | 0.78009302 |
55 | MAP2K4 | 0.72986424 |
56 | ACVR1B | 0.70912620 |
57 | TAOK3 | 0.68904654 |
58 | DYRK3 | 0.67737612 |
59 | ITK | 0.67213821 |
60 | CDC42BPA | 0.67192404 |
61 | TGFBR2 | 0.65925145 |
62 | TEC | 0.65198793 |
63 | SMG1 | 0.63832003 |
64 | STK11 | 0.63689133 |
65 | PRKD2 | 0.63035627 |
66 | WNK1 | 0.62258542 |
67 | PDK1 | 0.62210533 |
68 | MAP3K2 | 0.58763699 |
69 | BMPR2 | 0.58638963 |
70 | PDPK1 | 0.57935668 |
71 | FYN | 0.57704520 |
72 | IRAK3 | 0.56699062 |
73 | MAPK7 | 0.53325934 |
74 | MAP3K7 | 0.52620260 |
75 | DAPK2 | 0.48718586 |
76 | DYRK1B | 0.48648003 |
77 | RPS6KL1 | 0.47794198 |
78 | RPS6KC1 | 0.47794198 |
79 | SIK2 | 0.46891402 |
80 | PRKG2 | 0.46306525 |
81 | PIK3CG | 0.45540985 |
82 | SGK3 | 0.43586212 |
83 | MAPK12 | 0.41894667 |
84 | RPS6KA1 | 0.39827805 |
85 | RPS6KA6 | 0.39235372 |
86 | SIK1 | 0.36389957 |
87 | CDK4 | 0.36183785 |
88 | SGK2 | 0.36139675 |
89 | PIM1 | 0.35661504 |
90 | PASK | 0.35536823 |
91 | BRD4 | 0.33941206 |
92 | PAK4 | 0.33228974 |
93 | PRKCQ | 0.32954780 |
94 | CAMK1D | 0.32450385 |
95 | MAPKAPK2 | 0.32346024 |
96 | LRRK2 | 0.32309610 |
97 | FGFR3 | 0.32176740 |
98 | MAP3K8 | 0.31741072 |
99 | FGFR4 | 0.31721243 |
100 | MAP2K2 | 0.31402750 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Osteoclast differentiation_Homo sapiens_hsa04380 | 3.39957136 |
2 | Leishmaniasis_Homo sapiens_hsa05140 | 3.29197549 |
3 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 3.06530420 |
4 | Tuberculosis_Homo sapiens_hsa05152 | 2.54160061 |
5 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.51443401 |
6 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.28328162 |
7 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 2.23246373 |
8 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.20026640 |
9 | Legionellosis_Homo sapiens_hsa05134 | 2.19790649 |
10 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.03496928 |
11 | Malaria_Homo sapiens_hsa05144 | 2.01259259 |
12 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.97503353 |
13 | Allograft rejection_Homo sapiens_hsa05330 | 1.89675483 |
14 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.85099882 |
15 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.83481076 |
16 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.81867645 |
17 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.79591118 |
18 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.78099298 |
19 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.76581700 |
20 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.72159152 |
21 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.67490817 |
22 | Influenza A_Homo sapiens_hsa05164 | 1.65814096 |
23 | Measles_Homo sapiens_hsa05162 | 1.64508919 |
24 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.63062198 |
25 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.58598073 |
26 | Phagosome_Homo sapiens_hsa04145 | 1.54256535 |
27 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.53054424 |
28 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.51804668 |
29 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.36775816 |
30 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.36240680 |
31 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.35952255 |
32 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.35289621 |
33 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.34342566 |
34 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.33726674 |
35 | Viral myocarditis_Homo sapiens_hsa05416 | 1.32611650 |
36 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.28511838 |
37 | Hepatitis B_Homo sapiens_hsa05161 | 1.26832058 |
38 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.22022291 |
39 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.21741261 |
40 | Salmonella infection_Homo sapiens_hsa05132 | 1.19658404 |
41 | Pertussis_Homo sapiens_hsa05133 | 1.19146997 |
42 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.17900209 |
43 | Shigellosis_Homo sapiens_hsa05131 | 1.14478175 |
44 | Hepatitis C_Homo sapiens_hsa05160 | 1.09306033 |
45 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.05868325 |
46 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.05271114 |
47 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.03309327 |
48 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.01408268 |
49 | Platelet activation_Homo sapiens_hsa04611 | 0.98838590 |
50 | Apoptosis_Homo sapiens_hsa04210 | 0.97128232 |
51 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.93936617 |
52 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.93171964 |
53 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.92196682 |
54 | Lysosome_Homo sapiens_hsa04142 | 0.91640936 |
55 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.91391038 |
56 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.90161908 |
57 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.88316446 |
58 | Other glycan degradation_Homo sapiens_hsa00511 | 0.87905678 |
59 | Asthma_Homo sapiens_hsa05310 | 0.87600397 |
60 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.86164953 |
61 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.85172893 |
62 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.84491441 |
63 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.80381608 |
64 | Amoebiasis_Homo sapiens_hsa05146 | 0.78860497 |
65 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.76457965 |
66 | Endocytosis_Homo sapiens_hsa04144 | 0.75442495 |
67 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.71417380 |
68 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.69282215 |
69 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.68570302 |
70 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.67743310 |
71 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.65703420 |
72 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.64576475 |
73 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.63552395 |
74 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.62618001 |
75 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.62275976 |
76 | Colorectal cancer_Homo sapiens_hsa05210 | 0.61136447 |
77 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.59738072 |
78 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.59084477 |
79 | HTLV-I infection_Homo sapiens_hsa05166 | 0.57840183 |
80 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.55882545 |
81 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.55757621 |
82 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.54448966 |
83 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.54257261 |
84 | Endometrial cancer_Homo sapiens_hsa05213 | 0.54023793 |
85 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.52151621 |
86 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.49614173 |
87 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.49353961 |
88 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.49055785 |
89 | Bladder cancer_Homo sapiens_hsa05219 | 0.48623066 |
90 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.48029743 |
91 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.47059608 |
92 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.46913912 |
93 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.44184959 |
94 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.44048648 |
95 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.43071696 |
96 | Prostate cancer_Homo sapiens_hsa05215 | 0.42618153 |
97 | Insulin resistance_Homo sapiens_hsa04931 | 0.41728876 |
98 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.40900441 |
99 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.40374049 |
100 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.38560045 |