

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative regulation of transcription regulatory region DNA binding (GO:2000678) | 8.88208498 |
| 2 | erythrocyte development (GO:0048821) | 8.74828196 |
| 3 | adenine nucleotide transport (GO:0051503) | 8.72318058 |
| 4 | purine ribonucleotide transport (GO:0015868) | 8.71841164 |
| 5 | response to thyroid hormone (GO:0097066) | 8.14733810 |
| 6 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 8.11537201 |
| 7 | negative regulation of bone mineralization (GO:0030502) | 8.05722670 |
| 8 | mitochondrial calcium ion transport (GO:0006851) | 7.57979772 |
| 9 | platelet formation (GO:0030220) | 7.16946084 |
| 10 | negative regulation of biomineral tissue development (GO:0070168) | 7.15717993 |
| 11 | purine nucleotide transport (GO:0015865) | 6.80989763 |
| 12 | positive regulation of erythrocyte differentiation (GO:0045648) | 6.70649239 |
| 13 | positive regulation of insulin receptor signaling pathway (GO:0046628) | 6.67281575 |
| 14 | regulation of osteoblast proliferation (GO:0033688) | 6.53889003 |
| 15 | negative regulation of gluconeogenesis (GO:0045721) | 6.49174089 |
| 16 | embryonic hemopoiesis (GO:0035162) | 6.17844251 |
| 17 | respiratory chain complex IV assembly (GO:0008535) | 6.08817879 |
| 18 | negative regulation of JAK-STAT cascade (GO:0046426) | 5.89421880 |
| 19 | negative regulation of mast cell activation (GO:0033004) | 5.83981646 |
| 20 | negative regulation of anoikis (GO:2000811) | 5.56999918 |
| 21 | oxidative phosphorylation (GO:0006119) | 5.36838354 |
| 22 | regulation of transcription regulatory region DNA binding (GO:2000677) | 5.30986750 |
| 23 | regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358) | 5.30333331 |
| 24 | negative regulation of protein localization to cell surface (GO:2000009) | 5.17427477 |
| 25 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 5.10176250 |
| 26 | cytochrome complex assembly (GO:0017004) | 5.02798405 |
| 27 | nucleoside transport (GO:0015858) | 4.84956195 |
| 28 | positive regulation of cellular response to insulin stimulus (GO:1900078) | 4.80569923 |
| 29 | protein targeting to vacuole (GO:0006623) | 4.80496701 |
| 30 | protein targeting to lysosome (GO:0006622) | 4.80496701 |
| 31 | establishment of protein localization to vacuole (GO:0072666) | 4.80496701 |
| 32 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 4.76774330 |
| 33 | urinary tract smooth muscle contraction (GO:0014848) | 4.64919753 |
| 34 | mitochondrial calcium ion homeostasis (GO:0051560) | 4.63911362 |
| 35 | positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357 | 4.61492047 |
| 36 | regulation of anoikis (GO:2000209) | 4.44820760 |
| 37 | rRNA modification (GO:0000154) | 4.35798073 |
| 38 | myeloid cell development (GO:0061515) | 4.35563624 |
| 39 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.33453138 |
| 40 | NADH dehydrogenase complex assembly (GO:0010257) | 4.33453138 |
| 41 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.33453138 |
| 42 | monoubiquitinated protein deubiquitination (GO:0035520) | 4.32241727 |
| 43 | regulation of glycoprotein biosynthetic process (GO:0010559) | 4.28919692 |
| 44 | dendritic cell differentiation (GO:0097028) | 4.25832446 |
| 45 | positive regulation of cell cycle checkpoint (GO:1901978) | 4.17543350 |
| 46 | regulation of coenzyme metabolic process (GO:0051196) | 4.16034775 |
| 47 | regulation of cofactor metabolic process (GO:0051193) | 4.16034775 |
| 48 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001240) | 3.99532185 |
| 49 | negative regulation of signal transduction in absence of ligand (GO:1901099) | 3.99532185 |
| 50 | centriole replication (GO:0007099) | 3.91701561 |
| 51 | regulation of sulfur metabolic process (GO:0042762) | 3.88047495 |
| 52 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 3.83540214 |
| 53 | regulation of erythrocyte differentiation (GO:0045646) | 3.82988670 |
| 54 | intestinal absorption (GO:0050892) | 3.59886342 |
| 55 | centrosome duplication (GO:0051298) | 3.49154932 |
| 56 | regulation of glycoprotein metabolic process (GO:1903018) | 3.45109204 |
| 57 | aerobic respiration (GO:0009060) | 3.44016987 |
| 58 | mitotic cell cycle arrest (GO:0071850) | 3.41304090 |
| 59 | nucleotide transport (GO:0006862) | 3.34801103 |
| 60 | negative regulation of receptor-mediated endocytosis (GO:0048261) | 3.28870966 |
| 61 | sleep (GO:0030431) | 3.27585631 |
| 62 | tonic smooth muscle contraction (GO:0014820) | 3.26638254 |
| 63 | regulation of cardioblast proliferation (GO:0003264) | 3.26426876 |
| 64 | regulation of secondary heart field cardioblast proliferation (GO:0003266) | 3.26426876 |
| 65 | protein localization to lysosome (GO:0061462) | 3.25824609 |
| 66 | protein localization to vacuole (GO:0072665) | 3.25824609 |
| 67 | negative regulation of DNA binding (GO:0043392) | 3.22642421 |
| 68 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.20884946 |
| 69 | single strand break repair (GO:0000012) | 3.15785156 |
| 70 | histone H4-K16 acetylation (GO:0043984) | 3.15017871 |
| 71 | regulation of DNA methylation (GO:0044030) | 3.14908036 |
| 72 | platelet aggregation (GO:0070527) | 3.14616270 |
| 73 | sulfate transmembrane transport (GO:1902358) | 3.08179740 |
| 74 | negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948) | 3.06226159 |
| 75 | histone H4-K5 acetylation (GO:0043981) | 3.03687872 |
| 76 | histone H4-K8 acetylation (GO:0043982) | 3.03687872 |
| 77 | protein complex biogenesis (GO:0070271) | 3.02217025 |
| 78 | artery smooth muscle contraction (GO:0014824) | 3.01726483 |
| 79 | muscle organ morphogenesis (GO:0048644) | 3.00334413 |
| 80 | negative regulation of translational initiation (GO:0045947) | 2.98769073 |
| 81 | detection of temperature stimulus involved in sensory perception (GO:0050961) | 2.93976358 |
| 82 | detection of temperature stimulus involved in sensory perception of pain (GO:0050965) | 2.93976358 |
| 83 | outer ear morphogenesis (GO:0042473) | 2.91698718 |
| 84 | RNA localization (GO:0006403) | 2.88383287 |
| 85 | regulation of phospholipid biosynthetic process (GO:0071071) | 2.85218573 |
| 86 | snRNA transcription (GO:0009301) | 2.84947495 |
| 87 | mitotic sister chromatid cohesion (GO:0007064) | 2.84836044 |
| 88 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.81216260 |
| 89 | negative regulation of DNA replication (GO:0008156) | 2.77872597 |
| 90 | ribosome biogenesis (GO:0042254) | 2.73604833 |
| 91 | erythrocyte differentiation (GO:0030218) | 2.73323953 |
| 92 | DNA strand renaturation (GO:0000733) | 2.68259200 |
| 93 | sulfate transport (GO:0008272) | 2.67486327 |
| 94 | coronary vasculature morphogenesis (GO:0060977) | 2.67082909 |
| 95 | centriole assembly (GO:0098534) | 2.65564374 |
| 96 | positive regulation of osteoblast proliferation (GO:0033690) | 15.3648900 |
| 97 | cellular response to thyroid hormone stimulus (GO:0097067) | 11.4196031 |
| 98 | granulocyte differentiation (GO:0030851) | 10.4864055 |
| 99 | nuclear envelope reassembly (GO:0031468) | 10.2409632 |
| 100 | mitotic nuclear envelope reassembly (GO:0007084) | 10.2409632 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | GATA1_22025678_ChIP-Seq_K562_Human | 8.56185248 |
| 2 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 5.65424878 |
| 3 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 5.13154463 |
| 4 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.79545232 |
| 5 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 3.04200788 |
| 6 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 2.74699446 |
| 7 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.62666314 |
| 8 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.36057765 |
| 9 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.27055189 |
| 10 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 2.23400839 |
| 11 | GATA1_19941826_ChIP-Seq_K562_Human | 2.08693822 |
| 12 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.06945333 |
| 13 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.00448464 |
| 14 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.97881316 |
| 15 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.87637587 |
| 16 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.81502149 |
| 17 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.78351970 |
| 18 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 1.77703020 |
| 19 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.71326414 |
| 20 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.59934557 |
| 21 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.57574579 |
| 22 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.51032043 |
| 23 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.47367378 |
| 24 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.46050777 |
| 25 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.45422027 |
| 26 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.41547425 |
| 27 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.33338749 |
| 28 | SPI1_23127762_ChIP-Seq_K562_Human | 1.32933206 |
| 29 | ELF5_23300383_ChIP-Seq_T47D_Human | 1.32082218 |
| 30 | AR_25329375_ChIP-Seq_VCAP_Human | 1.29948110 |
| 31 | EWS_26573619_Chip-Seq_HEK293_Human | 1.28051113 |
| 32 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.27571984 |
| 33 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.27532496 |
| 34 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.25356896 |
| 35 | P68_20966046_ChIP-Seq_HELA_Human | 1.23316287 |
| 36 | GATA2_19941826_ChIP-Seq_K562_Human | 1.21518840 |
| 37 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.21383134 |
| 38 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.19124660 |
| 39 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.17604517 |
| 40 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.15669543 |
| 41 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 1.15477690 |
| 42 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.14727973 |
| 43 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.12463337 |
| 44 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.12385436 |
| 45 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.11639476 |
| 46 | EOMES_21245162_ChIP-Seq_HESCs_Human | 1.10764826 |
| 47 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.09404042 |
| 48 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.09404042 |
| 49 | CJUN_26792858_Chip-Seq_BT549_Human | 1.08122049 |
| 50 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.07970686 |
| 51 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.07906150 |
| 52 | FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.06412183 |
| 53 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.04563793 |
| 54 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 1.03153992 |
| 55 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 1.01018220 |
| 56 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.00597054 |
| 57 | TP53_16413492_ChIP-PET_HCT116_Human | 1.00006151 |
| 58 | NFI_21473784_ChIP-Seq_ESCs_Mouse | 0.99514232 |
| 59 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.99331888 |
| 60 | P300_19829295_ChIP-Seq_ESCs_Human | 0.98743913 |
| 61 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.98117501 |
| 62 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.98094569 |
| 63 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.97602262 |
| 64 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.97200426 |
| 65 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 0.95805264 |
| 66 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.94955097 |
| 67 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.94826125 |
| 68 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.94259549 |
| 69 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.94000424 |
| 70 | MAF_26560356_Chip-Seq_TH2_Human | 0.93628590 |
| 71 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.93133837 |
| 72 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.91963106 |
| 73 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.91660733 |
| 74 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 0.91072526 |
| 75 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.89606733 |
| 76 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.87729384 |
| 77 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.87110202 |
| 78 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.86122192 |
| 79 | GATA3_26560356_Chip-Seq_TH2_Human | 0.85438511 |
| 80 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.85104192 |
| 81 | P300_27268052_Chip-Seq_Bcells_Human | 0.85042551 |
| 82 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.84934186 |
| 83 | SMAD4_21741376_ChIP-Seq_ESCs_Human | 0.83496542 |
| 84 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.83373898 |
| 85 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.82569844 |
| 86 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 0.82526805 |
| 87 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.82108885 |
| 88 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.82077150 |
| 89 | POU3F1_26484290_ChIP-Seq_ESCss_Mouse | 0.81961158 |
| 90 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.81649674 |
| 91 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.81359830 |
| 92 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.81345022 |
| 93 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.81016619 |
| 94 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.80568465 |
| 95 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.80255960 |
| 96 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.79716055 |
| 97 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.79381855 |
| 98 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.79335196 |
| 99 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 0.79214007 |
| 100 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.79099645 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001661_extended_life_span | 6.87841112 |
| 2 | MP0001545_abnormal_hematopoietic_system | 4.67604551 |
| 3 | MP0005397_hematopoietic_system_phenotyp | 4.67604551 |
| 4 | MP0005360_urolithiasis | 4.14366364 |
| 5 | MP0003950_abnormal_plasma_membrane | 3.74308160 |
| 6 | MP0005171_absent_coat_pigmentation | 3.43684972 |
| 7 | MP0008872_abnormal_physiological_respon | 3.15041726 |
| 8 | MP0010386_abnormal_urinary_bladder | 2.22312858 |
| 9 | MP0003300_gastrointestinal_ulcer | 2.17630689 |
| 10 | MP0003111_abnormal_nucleus_morphology | 2.13799011 |
| 11 | MP0003787_abnormal_imprinting | 2.06155923 |
| 12 | MP0002132_abnormal_respiratory_system | 11.3927413 |
| 13 | MP0006036_abnormal_mitochondrial_physio | 1.82419128 |
| 14 | MP0002736_abnormal_nociception_after | 1.80629263 |
| 15 | MP0008057_abnormal_DNA_replication | 1.80393345 |
| 16 | MP0004147_increased_porphyrin_level | 1.75155627 |
| 17 | MP0000372_irregular_coat_pigmentation | 1.72700216 |
| 18 | MP0008438_abnormal_cutaneous_collagen | 1.62594908 |
| 19 | MP0000747_muscle_weakness | 1.56354062 |
| 20 | MP0005636_abnormal_mineral_homeostasis | 1.43079356 |
| 21 | MP0003693_abnormal_embryo_hatching | 1.41237866 |
| 22 | MP0005503_abnormal_tendon_morphology | 1.33546439 |
| 23 | MP0004782_abnormal_surfactant_physiolog | 1.32652387 |
| 24 | MP0008961_abnormal_basal_metabolism | 1.29056395 |
| 25 | MP0004885_abnormal_endolymph | 1.26575248 |
| 26 | MP0003453_abnormal_keratinocyte_physiol | 1.25380857 |
| 27 | MP0002234_abnormal_pharynx_morphology | 1.17618221 |
| 28 | MP0002133_abnormal_respiratory_system | 1.17258272 |
| 29 | MP0005388_respiratory_system_phenotype | 1.17258272 |
| 30 | MP0001697_abnormal_embryo_size | 1.15764956 |
| 31 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.15193737 |
| 32 | MP0010352_gastrointestinal_tract_polyps | 1.10690903 |
| 33 | MP0005501_abnormal_skin_physiology | 1.06978678 |
| 34 | MP0001764_abnormal_homeostasis | 1.06930692 |
| 35 | MP0005023_abnormal_wound_healing | 1.06512364 |
| 36 | MP0008770_decreased_survivor_rate | 1.05433425 |
| 37 | MP0010368_abnormal_lymphatic_system | 1.04352629 |
| 38 | MP0000569_abnormal_digit_pigmentation | 1.02651323 |
| 39 | MP0010094_abnormal_chromosome_stability | 0.95992999 |
| 40 | MP0000767_abnormal_smooth_muscle | 0.93991067 |
| 41 | MP0009672_abnormal_birth_weight | 0.90646167 |
| 42 | MP0006292_abnormal_olfactory_placode | 0.89179485 |
| 43 | MP0005174_abnormal_tail_pigmentation | 0.86907847 |
| 44 | MP0001968_abnormal_touch/_nociception | 0.86476847 |
| 45 | MP0001879_abnormal_lymphatic_vessel | 0.86383494 |
| 46 | MP0005275_abnormal_skin_tensile | 0.85057210 |
| 47 | MP0006138_congestive_heart_failure | 0.84043859 |
| 48 | MP0000538_abnormal_urinary_bladder | 0.81415908 |
| 49 | MP0000427_abnormal_hair_cycle | 0.77812869 |
| 50 | MP0003942_abnormal_urinary_system | 0.77181917 |
| 51 | MP0000313_abnormal_cell_death | 0.76711672 |
| 52 | MP0001243_abnormal_dermal_layer | 0.75834791 |
| 53 | MP0000678_abnormal_parathyroid_gland | 0.75358542 |
| 54 | MP0001853_heart_inflammation | 0.74798123 |
| 55 | MP0008875_abnormal_xenobiotic_pharmacok | 0.70761904 |
| 56 | MP0001542_abnormal_bone_strength | 0.69665886 |
| 57 | MP0004484_altered_response_of | 0.68993940 |
| 58 | MP0009115_abnormal_fat_cell | 0.66723699 |
| 59 | MP0002111_abnormal_tail_morphology | 0.64966206 |
| 60 | MP0003828_pulmonary_edema | 0.64677007 |
| 61 | MP0008874_decreased_physiological_sensi | 0.61648660 |
| 62 | MP0005083_abnormal_biliary_tract | 0.60183249 |
| 63 | MP0000003_abnormal_adipose_tissue | 0.60158326 |
| 64 | MP0004134_abnormal_chest_morphology | 0.59800514 |
| 65 | MP0004043_abnormal_pH_regulation | 0.59748114 |
| 66 | MP0000685_abnormal_immune_system | 0.57923043 |
| 67 | MP0009931_abnormal_skin_appearance | 0.56769013 |
| 68 | MP0003137_abnormal_impulse_conducting | 0.55875153 |
| 69 | MP0003718_maternal_effect | 0.54941273 |
| 70 | MP0004197_abnormal_fetal_growth/weight/ | 0.54501886 |
| 71 | MP0002177_abnormal_outer_ear | 0.51237418 |
| 72 | MP0009703_decreased_birth_body | 0.50825392 |
| 73 | MP0000703_abnormal_thymus_morphology | 0.50113554 |
| 74 | MP0009333_abnormal_splenocyte_physiolog | 0.50096631 |
| 75 | MP0009697_abnormal_copulation | 0.48920847 |
| 76 | MP0000681_abnormal_thyroid_gland | 0.46022070 |
| 77 | MP0001849_ear_inflammation | 0.45659637 |
| 78 | MP0002722_abnormal_immune_system | 0.44639381 |
| 79 | MP0010630_abnormal_cardiac_muscle | 0.44388999 |
| 80 | MP0002160_abnormal_reproductive_system | 0.44304031 |
| 81 | MP0000015_abnormal_ear_pigmentation | 0.43883862 |
| 82 | MP0003795_abnormal_bone_structure | 0.43382024 |
| 83 | MP0010769_abnormal_survival | 0.42996113 |
| 84 | MP0002933_joint_inflammation | 0.42822520 |
| 85 | MP0003755_abnormal_palate_morphology | 0.42314954 |
| 86 | MP0010771_integument_phenotype | 0.41988066 |
| 87 | MP0003077_abnormal_cell_cycle | 0.41569135 |
| 88 | MP0002249_abnormal_larynx_morphology | 0.41026997 |
| 89 | MP0003385_abnormal_body_wall | 0.40846240 |
| 90 | MP0010768_mortality/aging | 0.40343521 |
| 91 | MP0008932_abnormal_embryonic_tissue | 0.39774740 |
| 92 | MP0003763_abnormal_thymus_physiology | 0.39007290 |
| 93 | MP0000049_abnormal_middle_ear | 0.38127492 |
| 94 | MP0005220_abnormal_exocrine_pancreas | 0.38097360 |
| 95 | MP0004811_abnormal_neuron_physiology | 0.36559646 |
| 96 | MP0005395_other_phenotype | 0.36382712 |
| 97 | MP0002114_abnormal_axial_skeleton | 0.35646041 |
| 98 | MP0004270_analgesia | 0.34527287 |
| 99 | MP0000266_abnormal_heart_morphology | 0.34399828 |
| 100 | MP0010770_preweaning_lethality | 0.33912157 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acanthocytosis (HP:0001927) | 9.40066347 |
| 2 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 7.78494216 |
| 3 | Petechiae (HP:0000967) | 7.33709854 |
| 4 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 7.06496912 |
| 5 | Broad palm (HP:0001169) | 6.75046643 |
| 6 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 6.62048161 |
| 7 | Short 5th finger (HP:0009237) | 6.38756336 |
| 8 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 6.08653762 |
| 9 | Aplasia/Hypoplasia of the 5th finger (HP:0006262) | 5.91341981 |
| 10 | Protruding tongue (HP:0010808) | 5.77874919 |
| 11 | Hypoplastic iliac wings (HP:0002866) | 5.68832463 |
| 12 | Polycythemia (HP:0001901) | 5.43537913 |
| 13 | Complete atrioventricular canal defect (HP:0001674) | 5.13172071 |
| 14 | Brushfield spots (HP:0001088) | 4.95943269 |
| 15 | Poikilocytosis (HP:0004447) | 4.84148696 |
| 16 | Abnormal platelet function (HP:0011869) | 4.68265514 |
| 17 | Impaired platelet aggregation (HP:0003540) | 4.68265514 |
| 18 | Reticulocytosis (HP:0001923) | 4.63575775 |
| 19 | Abnormality of dental color (HP:0011073) | 4.53093147 |
| 20 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 4.49944942 |
| 21 | Prolonged bleeding time (HP:0003010) | 4.03954355 |
| 22 | Atrioventricular canal defect (HP:0006695) | 3.92780879 |
| 23 | Short middle phalanx of finger (HP:0005819) | 3.89037956 |
| 24 | Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843) | 3.54205448 |
| 25 | Deep palmar crease (HP:0006191) | 3.49828173 |
| 26 | Hepatocellular necrosis (HP:0001404) | 3.45164685 |
| 27 | Abnormality of reticulocytes (HP:0004312) | 3.33823683 |
| 28 | Hypoplastic ilia (HP:0000946) | 3.22422660 |
| 29 | Hyperinsulinemic hypoglycemia (HP:0000825) | 3.16769530 |
| 30 | Abnormality of the wing of the ilium (HP:0011867) | 3.10566439 |
| 31 | Microtia (HP:0008551) | 3.06585567 |
| 32 | Facial hemangioma (HP:0000329) | 2.99221962 |
| 33 | Small intestinal stenosis (HP:0012848) | 2.99088466 |
| 34 | Duodenal stenosis (HP:0100867) | 2.99088466 |
| 35 | Abnormality of the middle phalanges of the hand (HP:0009833) | 2.91221020 |
| 36 | Testicular atrophy (HP:0000029) | 2.65116928 |
| 37 | Abnormality of the renal collecting system (HP:0004742) | 2.61157245 |
| 38 | Duplicated collecting system (HP:0000081) | 2.60926068 |
| 39 | Acute necrotizing encephalopathy (HP:0006965) | 2.57211059 |
| 40 | Hepatic necrosis (HP:0002605) | 2.57143055 |
| 41 | Abnormality of the acetabulum (HP:0003170) | 2.56220462 |
| 42 | Mitochondrial inheritance (HP:0001427) | 2.49271970 |
| 43 | Increased CSF lactate (HP:0002490) | 2.44166379 |
| 44 | Abnormality of the duodenum (HP:0002246) | 2.41925166 |
| 45 | Nonimmune hydrops fetalis (HP:0001790) | 2.38523328 |
| 46 | Type I transferrin isoform profile (HP:0003642) | 2.34786438 |
| 47 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.34695235 |
| 48 | Abnormality of alanine metabolism (HP:0010916) | 2.34695235 |
| 49 | Hyperalaninemia (HP:0003348) | 2.34695235 |
| 50 | Macroglossia (HP:0000158) | 2.31024963 |
| 51 | Anal atresia (HP:0002023) | 2.26270873 |
| 52 | Thickened nuchal skin fold (HP:0000474) | 2.26045682 |
| 53 | Progressive macrocephaly (HP:0004481) | 2.21887466 |
| 54 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.17669666 |
| 55 | Overlapping toe (HP:0001845) | 2.12833433 |
| 56 | Delayed puberty (HP:0000823) | 2.08932607 |
| 57 | Rectal prolapse (HP:0002035) | 2.05156434 |
| 58 | Ulnar deviation of the wrist (HP:0003049) | 2.04180951 |
| 59 | CNS demyelination (HP:0007305) | 2.03926557 |
| 60 | Short middle phalanx of the 5th finger (HP:0004220) | 12.5309253 |
| 61 | Acute encephalopathy (HP:0006846) | 1.99818986 |
| 62 | Microglossia (HP:0000171) | 1.98695458 |
| 63 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.95399292 |
| 64 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.95399292 |
| 65 | Abnormal protein glycosylation (HP:0012346) | 1.95399292 |
| 66 | Abnormal glycosylation (HP:0012345) | 1.95399292 |
| 67 | Broad alveolar ridges (HP:0000187) | 1.95370854 |
| 68 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.86232307 |
| 69 | Cutaneous photosensitivity (HP:0000992) | 1.79653993 |
| 70 | Macrocytic anemia (HP:0001972) | 1.78820580 |
| 71 | Synostosis involving the elbow (HP:0003938) | 1.78174608 |
| 72 | Humeroradial synostosis (HP:0003041) | 1.78174608 |
| 73 | Short palm (HP:0004279) | 1.75285892 |
| 74 | Pallor (HP:0000980) | 1.74492133 |
| 75 | Abnormal number of erythroid precursors (HP:0012131) | 1.69318935 |
| 76 | Neutropenia (HP:0001875) | 1.68378166 |
| 77 | Respiratory failure (HP:0002878) | 1.62801450 |
| 78 | Joint laxity (HP:0001388) | 1.61680260 |
| 79 | Anteriorly placed anus (HP:0001545) | 1.61118517 |
| 80 | Hirsutism (HP:0001007) | 1.57429008 |
| 81 | Chromsome breakage (HP:0040012) | 1.55620137 |
| 82 | Heterotopia (HP:0002282) | 1.54283834 |
| 83 | Cerebral edema (HP:0002181) | 1.52600332 |
| 84 | Broad ribs (HP:0000885) | 1.51008808 |
| 85 | Brachycephaly (HP:0000248) | 1.46195540 |
| 86 | Abnormality of cochlea (HP:0000375) | 1.46137902 |
| 87 | Epistaxis (HP:0000421) | 1.42536958 |
| 88 | Abnormality of DNA repair (HP:0003254) | 1.41646366 |
| 89 | Sparse lateral eyebrow (HP:0005338) | 1.40919143 |
| 90 | Nasolacrimal duct obstruction (HP:0000579) | 1.39048750 |
| 91 | Increased number of teeth (HP:0011069) | 1.38838728 |
| 92 | Short palpebral fissure (HP:0012745) | 1.38699659 |
| 93 | Mesomelia (HP:0003027) | 1.38125459 |
| 94 | Abnormality of homocysteine metabolism (HP:0010919) | 1.37342727 |
| 95 | Homocystinuria (HP:0002156) | 1.37342727 |
| 96 | Wide nose (HP:0000445) | 1.36352307 |
| 97 | Emotional lability (HP:0000712) | 1.35116577 |
| 98 | Abnormality of the alveolar ridges (HP:0006477) | 1.33992752 |
| 99 | Abnormality of the humerus (HP:0003063) | 1.33220101 |
| 100 | Rough bone trabeculation (HP:0100670) | 1.30578709 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PDK2 | 8.46397023 |
| 2 | CDK12 | 8.23746101 |
| 3 | ERN1 | 5.35002295 |
| 4 | AKT3 | 4.41298266 |
| 5 | CDK8 | 4.10081358 |
| 6 | EEF2K | 2.96018750 |
| 7 | EPHA3 | 2.19877107 |
| 8 | OXSR1 | 2.04270831 |
| 9 | MAP3K10 | 1.99172517 |
| 10 | MAPKAPK3 | 1.68085655 |
| 11 | STK39 | 1.66874404 |
| 12 | DMPK | 1.63110612 |
| 13 | SIK2 | 1.53021120 |
| 14 | TRPM7 | 1.52970580 |
| 15 | FRK | 1.47387875 |
| 16 | MST4 | 1.44085150 |
| 17 | MYLK | 1.41883107 |
| 18 | EPHB1 | 1.30371052 |
| 19 | FGFR4 | 1.29972359 |
| 20 | STK4 | 1.27488181 |
| 21 | MKNK2 | 1.21221873 |
| 22 | PRKD1 | 1.18965842 |
| 23 | NUAK1 | 1.17515643 |
| 24 | ACVR1B | 1.16958465 |
| 25 | MAPKAPK5 | 1.15465226 |
| 26 | WNK4 | 1.02627129 |
| 27 | PRKCI | 0.87162500 |
| 28 | BRD4 | 0.82650573 |
| 29 | FGFR3 | 0.81234160 |
| 30 | PDPK1 | 0.71592142 |
| 31 | RPS6KB2 | 0.69094693 |
| 32 | NLK | 0.66011019 |
| 33 | MAP3K7 | 0.63780215 |
| 34 | ALK | 0.57193472 |
| 35 | FGFR2 | 0.56291592 |
| 36 | FER | 0.53511824 |
| 37 | NEK2 | 0.52890624 |
| 38 | AKT1 | 0.50004477 |
| 39 | PAK3 | 0.48703458 |
| 40 | IRAK1 | 0.48006424 |
| 41 | MTOR | 0.47644147 |
| 42 | BRAF | 0.46479448 |
| 43 | BRSK2 | 0.45080877 |
| 44 | TRIB3 | 0.45020712 |
| 45 | ADRBK2 | 0.42367911 |
| 46 | ERBB4 | 0.41753471 |
| 47 | MARK2 | 0.38697356 |
| 48 | CHEK2 | 0.38041657 |
| 49 | MKNK1 | 0.36202921 |
| 50 | MAPK3 | 0.34469642 |
| 51 | CDK7 | 0.32759211 |
| 52 | PDK1 | 0.32622735 |
| 53 | BMPR1B | 0.31862825 |
| 54 | AURKB | 0.31259214 |
| 55 | CHEK1 | 0.31039511 |
| 56 | MAPK13 | 0.30600865 |
| 57 | PRKCE | 0.29047938 |
| 58 | PRKG2 | 0.27524518 |
| 59 | CDK4 | 0.27195335 |
| 60 | PRKCG | 0.26030818 |
| 61 | MAPK1 | 0.24763816 |
| 62 | PRKCZ | 0.24747477 |
| 63 | MAPK12 | 0.22444745 |
| 64 | RPS6KA1 | 0.21143124 |
| 65 | FLT3 | 0.20087568 |
| 66 | ADRBK1 | 0.18772952 |
| 67 | MAPK15 | 0.17830404 |
| 68 | LMTK2 | 0.16965972 |
| 69 | GRK1 | 0.16389311 |
| 70 | ROCK1 | 0.16148120 |
| 71 | ATR | 0.15960314 |
| 72 | MAPK14 | 0.15881622 |
| 73 | PDGFRB | 0.15812341 |
| 74 | DDR2 | 0.15278202 |
| 75 | MAPK4 | 0.14817629 |
| 76 | PAK2 | 0.13520442 |
| 77 | RET | 0.13219406 |
| 78 | PTK2 | 0.13128815 |
| 79 | RIPK4 | 0.12373378 |
| 80 | ILK | 0.11833284 |
| 81 | BUB1 | 0.11671928 |
| 82 | TESK2 | 0.11551385 |
| 83 | CHUK | 0.10825173 |
| 84 | MAPKAPK2 | 0.10714875 |
| 85 | RPS6KA5 | 0.10518959 |
| 86 | DAPK3 | 0.10509570 |
| 87 | PRKCA | 0.10453895 |
| 88 | PIK3CG | 0.10295918 |
| 89 | RAF1 | 0.09857666 |
| 90 | JAK2 | 0.09468495 |
| 91 | CAMKK2 | 0.09099962 |
| 92 | BCKDK | 0.08913743 |
| 93 | MELK | 0.08601511 |
| 94 | PIM1 | 0.07874974 |
| 95 | IRAK4 | 0.07419028 |
| 96 | CSNK1E | 0.06402294 |
| 97 | NTRK3 | 0.06226187 |
| 98 | KIT | 0.05984663 |
| 99 | OBSCN | 0.05447213 |
| 100 | BLK | 0.05217571 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 5.39298005 |
| 2 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 3.88499416 |
| 3 | Selenocompound metabolism_Homo sapiens_hsa00450 | 3.41804646 |
| 4 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 3.22096786 |
| 5 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 2.96329952 |
| 6 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 2.85498451 |
| 7 | Basal transcription factors_Homo sapiens_hsa03022 | 2.84362703 |
| 8 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.71357353 |
| 9 | Taste transduction_Homo sapiens_hsa04742 | 2.65233853 |
| 10 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.63693260 |
| 11 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 2.29029591 |
| 12 | Salmonella infection_Homo sapiens_hsa05132 | 2.28828019 |
| 13 | p53 signaling pathway_Homo sapiens_hsa04115 | 2.24980940 |
| 14 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 2.06523319 |
| 15 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.64561649 |
| 16 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.62943040 |
| 17 | RNA degradation_Homo sapiens_hsa03018 | 1.59562237 |
| 18 | Lysine degradation_Homo sapiens_hsa00310 | 1.51314251 |
| 19 | Mineral absorption_Homo sapiens_hsa04978 | 1.47208552 |
| 20 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.42582092 |
| 21 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.36787687 |
| 22 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.31497859 |
| 23 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.28441187 |
| 24 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.26685477 |
| 25 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.25007624 |
| 26 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.17816566 |
| 27 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.14296639 |
| 28 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.11866747 |
| 29 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.08629293 |
| 30 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.08117594 |
| 31 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.06005910 |
| 32 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.04563667 |
| 33 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.04239414 |
| 34 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.03325850 |
| 35 | Cell cycle_Homo sapiens_hsa04110 | 1.01430124 |
| 36 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.00097896 |
| 37 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.97113334 |
| 38 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.85339719 |
| 39 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.82552744 |
| 40 | Protein export_Homo sapiens_hsa03060 | 0.78741779 |
| 41 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.76478629 |
| 42 | RNA transport_Homo sapiens_hsa03013 | 0.74958509 |
| 43 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.73500072 |
| 44 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.69108868 |
| 45 | Gap junction_Homo sapiens_hsa04540 | 0.68811201 |
| 46 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.65867099 |
| 47 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.65352784 |
| 48 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.64590428 |
| 49 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.63714335 |
| 50 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.61017888 |
| 51 | Bladder cancer_Homo sapiens_hsa05219 | 0.60302269 |
| 52 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.59946147 |
| 53 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.59616757 |
| 54 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.58311470 |
| 55 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.55546607 |
| 56 | Apoptosis_Homo sapiens_hsa04210 | 0.54203490 |
| 57 | Hepatitis B_Homo sapiens_hsa05161 | 0.49939255 |
| 58 | Alcoholism_Homo sapiens_hsa05034 | 0.49420819 |
| 59 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.49375334 |
| 60 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.47231620 |
| 61 | Other glycan degradation_Homo sapiens_hsa00511 | 0.47172036 |
| 62 | Spliceosome_Homo sapiens_hsa03040 | 0.46691808 |
| 63 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.46127797 |
| 64 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.44501512 |
| 65 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.44361551 |
| 66 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.44304444 |
| 67 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.44191798 |
| 68 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.43284151 |
| 69 | Insulin resistance_Homo sapiens_hsa04931 | 0.42762996 |
| 70 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.42700360 |
| 71 | Legionellosis_Homo sapiens_hsa05134 | 0.41682433 |
| 72 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.41351936 |
| 73 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.41241424 |
| 74 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.39412896 |
| 75 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.38655312 |
| 76 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.37806920 |
| 77 | Phagosome_Homo sapiens_hsa04145 | 0.37803744 |
| 78 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.37229732 |
| 79 | GABAergic synapse_Homo sapiens_hsa04727 | 0.35917076 |
| 80 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.35771467 |
| 81 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.35560276 |
| 82 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.35531332 |
| 83 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.34045358 |
| 84 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.33858196 |
| 85 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.32977446 |
| 86 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.32369791 |
| 87 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.31673913 |
| 88 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.31017600 |
| 89 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.29775098 |
| 90 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.28741176 |
| 91 | Insulin secretion_Homo sapiens_hsa04911 | 0.28127441 |
| 92 | Melanoma_Homo sapiens_hsa05218 | 0.27334665 |
| 93 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.27278239 |
| 94 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.27251577 |
| 95 | Carbon metabolism_Homo sapiens_hsa01200 | 0.26612985 |
| 96 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.26401022 |
| 97 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.26098019 |
| 98 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.25323545 |
| 99 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.24861715 |
| 100 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.23028505 |

