ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein K11-linked deubiquitination (GO:0035871)	6.34644760
2	regulation of germinal center formation (GO:0002634)	5.49567688
3	secondary heart field specification (GO:0003139)	5.44328879
4	heart field specification (GO:0003128)	5.44328879
5	regulation of timing of cell differentiation (GO:0048505)	5.06799080
6	protein-cofactor linkage (GO:0018065)	4.82347432
7	exocrine pancreas development (GO:0031017)	4.77752371
8	DNA double-strand break processing (GO:0000729)	4.71866234
9	regulation of telomere maintenance via telomerase (GO:0032210)	4.71406347
10	positive regulation of cardiac muscle cell differentiation (GO:2000727)	4.68015622
11	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.66586528
12	hindbrain development (GO:0030902)	4.46680313
13	regulation of development, heterochronic (GO:0040034)	4.45375384
14	acrosome reaction (GO:0007340)	4.42761870
15	opioid receptor signaling pathway (GO:0038003)	4.33590180
16	neuron recognition (GO:0008038)	4.27931057
17	negative chemotaxis (GO:0050919)	4.25178187
18	presynaptic membrane organization (GO:0097090)	4.19441955
19	central nervous system projection neuron axonogenesis (GO:0021952)	4.19433379
20	nerve growth factor signaling pathway (GO:0038180)	4.04596598
21	specification of organ identity (GO:0010092)	3.99159666
22	lung secretory cell differentiation (GO:0061140)	3.93472451
23	negative regulation of microtubule polymerization (GO:0031115)	3.93254043
24	positive regulation of CREB transcription factor activity (GO:0032793)	3.91169082
25	dentate gyrus development (GO:0021542)	3.81541539
26	regulation of telomere maintenance (GO:0032204)	3.81392709
27	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.79040849
28	inositol phosphate catabolic process (GO:0071545)	3.63448831
29	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.57255230
30	seminiferous tubule development (GO:0072520)	3.55429500
31	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	3.55163069
32	central nervous system neuron axonogenesis (GO:0021955)	3.52414095
33	telomere maintenance via telomerase (GO:0007004)	3.50832492
34	centriole replication (GO:0007099)	3.50681061
35	neuron remodeling (GO:0016322)	3.49825905
36	viral mRNA export from host cell nucleus (GO:0046784)	3.38896769
37	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.33008941
38	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.33008941
39	long term synaptic depression (GO:0060292)	3.28374669
40	cardiac left ventricle morphogenesis (GO:0003214)	3.27139892
41	regulation of platelet aggregation (GO:0090330)	3.21192544
42	negative regulation of axon extension (GO:0030517)	3.19481247
43	negative regulation of telomere maintenance (GO:0032205)	3.19101914
44	mitochondrial genome maintenance (GO:0000002)	3.18811871
45	regulation of protein glycosylation (GO:0060049)	3.17012904
46	regulation of collateral sprouting (GO:0048670)	3.13714758
47	long-chain fatty acid biosynthetic process (GO:0042759)	3.12874347
48	nucleobase biosynthetic process (GO:0046112)	3.11141543
49	positive regulation of protein homodimerization activity (GO:0090073)	3.10235625
50	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.10079343
51	ventricular trabecula myocardium morphogenesis (GO:0003222)	3.09401478
52	morphogenesis of an endothelium (GO:0003159)	3.07206027
53	endothelial tube morphogenesis (GO:0061154)	3.07206027
54	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.06750053
55	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.06750053
56	NADH dehydrogenase complex assembly (GO:0010257)	3.06750053
57	polyol catabolic process (GO:0046174)	3.06650763
58	neural tube formation (GO:0001841)	3.01344086
59	olfactory bulb development (GO:0021772)	3.01245985
60	DNA deamination (GO:0045006)	3.00824619
61	microtubule depolymerization (GO:0007019)	3.00751847
62	heparin biosynthetic process (GO:0030210)	2.99524068
63	heparin metabolic process (GO:0030202)	2.99524068
64	replicative senescence (GO:0090399)	2.97720478
65	spinal cord motor neuron differentiation (GO:0021522)	2.96218292
66	lung epithelial cell differentiation (GO:0060487)	2.93705689
67	pyrimidine nucleobase catabolic process (GO:0006208)	2.92548306
68	negative regulation of B cell proliferation (GO:0030889)	2.92477029
69	regulation of clathrin-mediated endocytosis (GO:2000369)	2.90517582
70	neuron maturation (GO:0042551)	2.90039903
71	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.88628958
72	positive regulation of cell fate commitment (GO:0010455)	2.86101458
73	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.79841276
74	dendrite morphogenesis (GO:0048813)	2.77301085
75	microtubule nucleation (GO:0007020)	2.76877378
76	GMP metabolic process (GO:0046037)	2.75402482
77	mRNA splice site selection (GO:0006376)	2.75398357
78	negative regulation of meiotic cell cycle (GO:0051447)	2.74963287
79	microtubule polymerization or depolymerization (GO:0031109)	2.72796596
80	cerebellum development (GO:0021549)	2.70829166
81	response to amphetamine (GO:0001975)	2.69924475
82	protein localization to synapse (GO:0035418)	2.68972117
83	lung cell differentiation (GO:0060479)	2.68644878
84	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	2.68412345
85	presynaptic membrane assembly (GO:0097105)	2.65763257
86	L-fucose catabolic process (GO:0042355)	2.65270143
87	fucose catabolic process (GO:0019317)	2.65270143
88	L-fucose metabolic process (GO:0042354)	2.65270143
89	response to misfolded protein (GO:0051788)	2.63987841
90	negative regulation of mRNA processing (GO:0050686)	2.63534551
91	B cell homeostasis (GO:0001782)	2.63400176
92	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	2.62986013
93	mitochondrial respiratory chain complex assembly (GO:0033108)	2.62209052
94	negative regulation of dendrite development (GO:2000171)	2.62091034
95	purine nucleobase biosynthetic process (GO:0009113)	2.61742922
96	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.61719785
97	negative regulation of T-helper cell differentiation (GO:0045623)	2.61719785
98	rRNA catabolic process (GO:0016075)	2.58413622
99	protein localization to chromosome (GO:0034502)	2.54126327
100	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.52882511

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.89325224
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.83597561
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.44631658
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.32247805
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.17532287
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.99992271
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.78107649
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.64090048
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.54431898
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.51920974
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.42422606
12	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.35810563
13	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.33604946
14	FUS_26573619_Chip-Seq_HEK293_Human	2.25002036
15	AR_21572438_ChIP-Seq_LNCaP_Human	2.16306393
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.11807650
17	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.09694387
18	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.09694387
19	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.05922280
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.91639062
21	EWS_26573619_Chip-Seq_HEK293_Human	1.90797319
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.79459999
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.69719133
24	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.68387017
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.67796981
26	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.64102834
27	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.63435503
28	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.62780536
29	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.62380562
30	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.62151398
31	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.58545586
32	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.57545714
33	P300_19829295_ChIP-Seq_ESCs_Human	1.56658345
34	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.56574461
35	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.54361453
36	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.50844875
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.49754110
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48871734
39	AR_25329375_ChIP-Seq_VCAP_Human	1.46815270
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.46338034
41	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.38104306
42	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.37652639
43	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.37317047
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.35551783
45	VDR_22108803_ChIP-Seq_LS180_Human	1.35185284
46	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.34359160
47	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.31849115
48	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.31788197
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.31616933
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.31410758
51	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.30823237
52	REST_21632747_ChIP-Seq_MESCs_Mouse	1.28228984
53	ER_23166858_ChIP-Seq_MCF-7_Human	1.28056278
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.26047345
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25102123
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.25102123
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.24768468
58	TCF4_23295773_ChIP-Seq_U87_Human	1.24270098
59	GATA3_26560356_Chip-Seq_TH2_Human	1.20942741
60	TP53_18474530_ChIP-ChIP_U2OS_Human	1.18602760
61	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.17922784
62	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16333065
63	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14842335
64	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.12868437
65	CIITA_25753668_ChIP-Seq_RAJI_Human	1.12849783
66	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.10966897
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10732166
68	TP53_16413492_ChIP-PET_HCT116_Human	1.10546801
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09678005
70	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.09649149
71	RNF2_27304074_Chip-Seq_NSC_Mouse	1.08750981
72	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.08017373
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06115165
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06115165
75	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.05207508
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04755559
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04493499
78	TCF4_22108803_ChIP-Seq_LS180_Human	1.04134300
79	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03344715
80	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01005984
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99857183
82	JUN_21703547_ChIP-Seq_K562_Human	0.99095039
83	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.98480550
84	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.97748204
85	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.97332365
86	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.97303931
87	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.96905697
88	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96671478
89	STAT3_23295773_ChIP-Seq_U87_Human	0.96621239
90	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.95291704
91	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.94103105
92	KDM2B_26808549_Chip-Seq_REH_Human	0.93716505
93	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.93509454
94	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.93306663
95	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.93010984
96	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.91967872
97	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.91435264
98	P53_22387025_ChIP-Seq_ESCs_Mouse	0.91056910
99	RUNX2_22187159_ChIP-Seq_PCA_Human	0.89133866
100	SMAD4_21799915_ChIP-Seq_A2780_Human	0.88295767

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.17498992
2	MP0008877_abnormal_DNA_methylation	3.70751426
3	MP0003880_abnormal_central_pattern	3.61809239
4	MP0005423_abnormal_somatic_nervous	3.47654044
5	MP0003806_abnormal_nucleotide_metabolis	2.95943836
6	MP0001986_abnormal_taste_sensitivity	2.91108427
7	MP0002396_abnormal_hematopoietic_system	2.90245635
8	MP0003787_abnormal_imprinting	2.85061846
9	MP0000372_irregular_coat_pigmentation	2.84248192
10	MP0006072_abnormal_retinal_apoptosis	2.77536237
11	MP0000778_abnormal_nervous_system	2.66291400
12	MP0006292_abnormal_olfactory_placode	2.63003697
13	MP0000015_abnormal_ear_pigmentation	2.60961568
14	MP0003656_abnormal_erythrocyte_physiolo	2.57959639
15	MP0005084_abnormal_gallbladder_morpholo	2.33639516
16	MP0008789_abnormal_olfactory_epithelium	2.31412268
17	MP0008057_abnormal_DNA_replication	2.26043981
18	MP0004270_analgesia	2.21599666
19	MP0003718_maternal_effect	2.14061052
20	MP0005174_abnormal_tail_pigmentation	1.89547447
21	MP0005499_abnormal_olfactory_system	1.86460135
22	MP0005394_taste/olfaction_phenotype	1.86460135
23	MP0010094_abnormal_chromosome_stability	1.81152341
24	MP0002653_abnormal_ependyma_morphology	1.80231491
25	MP0005171_absent_coat_pigmentation	1.77478534
26	MP0001501_abnormal_sleep_pattern	1.76025899
27	MP0000371_diluted_coat_color	1.68319537
28	MP0008872_abnormal_physiological_respon	1.65154197
29	MP0003635_abnormal_synaptic_transmissio	1.63629975
30	MP0005551_abnormal_eye_electrophysiolog	1.58243863
31	MP0005360_urolithiasis	1.56929656
32	MP0002138_abnormal_hepatobiliary_system	1.56152337
33	MP0003567_abnormal_fetal_cardiomyocyte	1.53635788
34	MP0001177_atelectasis	1.46556892
35	MP0005253_abnormal_eye_physiology	1.42800583
36	MP0004130_abnormal_muscle_cell	1.40528735
37	MP0001790_abnormal_immune_system	1.23347220
38	MP0005387_immune_system_phenotype	1.23347220
39	MP0001800_abnormal_humoral_immune	1.19968241
40	MP0001968_abnormal_touch/_nociception	1.15591435
41	MP0001486_abnormal_startle_reflex	1.12319243
42	MP0002063_abnormal_learning/memory/cond	1.10743204
43	MP0009697_abnormal_copulation	1.09480738
44	MP0008058_abnormal_DNA_repair	1.07022823
45	MP0002184_abnormal_innervation	1.05000343
46	MP0002734_abnormal_mechanical_nocicepti	1.04140321
47	MP0001664_abnormal_digestion	1.03344463
48	MP0006276_abnormal_autonomic_nervous	0.99951140
49	MP0002095_abnormal_skin_pigmentation	0.94237114
50	MP0000685_abnormal_immune_system	0.91878739
51	MP0000465_gastrointestinal_hemorrhage	0.90953599
52	MP0002102_abnormal_ear_morphology	0.90871335
53	MP0005220_abnormal_exocrine_pancreas	0.90201500
54	MP0001188_hyperpigmentation	0.90168287
55	MP0002735_abnormal_chemical_nociception	0.88787779
56	MP0001835_abnormal_antigen_presentation	0.87006822
57	MP0009745_abnormal_behavioral_response	0.86336917
58	MP0003303_peritoneal_inflammation	0.85453677
59	MP0002160_abnormal_reproductive_system	0.84852115
60	MP0000955_abnormal_spinal_cord	0.84760859
61	MP0002098_abnormal_vibrissa_morphology	0.83352035
62	MP0003121_genomic_imprinting	0.83070160
63	MP0002067_abnormal_sensory_capabilities	0.82063817
64	MP0002928_abnormal_bile_duct	0.81612717
65	MP0003724_increased_susceptibility_to	0.81144947
66	MP0005389_reproductive_system_phenotype	0.80473142
67	MP0002751_abnormal_autonomic_nervous	0.80093973
68	MP0002272_abnormal_nervous_system	0.80010166
69	MP0005503_abnormal_tendon_morphology	0.78364402
70	MP0008875_abnormal_xenobiotic_pharmacok	0.77890002
71	MP0002752_abnormal_somatic_nervous	0.77790939
72	MP0002733_abnormal_thermal_nociception	0.76157286
73	MP0009053_abnormal_anal_canal	0.76021465
74	MP0002075_abnormal_coat/hair_pigmentati	0.75012486
75	MP0002736_abnormal_nociception_after	0.73793017
76	MP0001919_abnormal_reproductive_system	0.73712956
77	MP0003633_abnormal_nervous_system	0.73299999
78	MP0001765_abnormal_ion_homeostasis	0.72757695
79	MP0001186_pigmentation_phenotype	0.72714455
80	MP0001663_abnormal_digestive_system	0.72611964
81	MP0005381_digestive/alimentary_phenotyp	0.71825181
82	MP0000631_abnormal_neuroendocrine_gland	0.71653501
83	MP0002882_abnormal_neuron_morphology	0.71599867
84	MP0000534_abnormal_ureter_morphology	0.71374731
85	MP0005386_behavior/neurological_phenoty	0.70807601
86	MP0004924_abnormal_behavior	0.70807601
87	MP0000490_abnormal_crypts_of	0.70393575
88	MP0003861_abnormal_nervous_system	0.69671585
89	MP0008569_lethality_at_weaning	0.69279150
90	MP0000689_abnormal_spleen_morphology	0.67884835
91	MP0001545_abnormal_hematopoietic_system	0.67858443
92	MP0005397_hematopoietic_system_phenotyp	0.67858443
93	MP0003315_abnormal_perineum_morphology	0.65535120
94	MP0002234_abnormal_pharynx_morphology	0.65143313
95	MP0002723_abnormal_immune_serum	0.65056580
96	MP0010386_abnormal_urinary_bladder	0.63976571
97	MP0003890_abnormal_embryonic-extraembry	0.63882534
98	MP0009384_cardiac_valve_regurgitation	0.63067331
99	MP0000462_abnormal_digestive_system	0.62778247
100	MP0002452_abnormal_antigen_presenting	0.60741229

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Short chin (HP:0000331)	5.13477252
2	Focal motor seizures (HP:0011153)	5.12107160
3	Chromsome breakage (HP:0040012)	4.78590449
4	Metaphyseal dysplasia (HP:0100255)	3.70189532
5	Abnormality of chromosome stability (HP:0003220)	3.63841702
6	Focal seizures (HP:0007359)	3.43135986
7	Pancreatic fibrosis (HP:0100732)	3.37112325
8	Exotropia (HP:0000577)	3.31502938
9	Short tibia (HP:0005736)	3.11533566
10	Ependymoma (HP:0002888)	3.10532827
11	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.08233647
12	Long clavicles (HP:0000890)	3.06974059
13	Protruding tongue (HP:0010808)	3.06443456
14	Retinal dysplasia (HP:0007973)	2.85588001
15	Adactyly (HP:0009776)	2.84668639
16	Thyroiditis (HP:0100646)	2.75782093
17	Tubulointerstitial nephritis (HP:0001970)	2.73608991
18	Hyperventilation (HP:0002883)	2.71490553
19	Generalized hypopigmentation of hair (HP:0011358)	2.70818926
20	Severe combined immunodeficiency (HP:0004430)	2.70430189
21	Limb hypertonia (HP:0002509)	2.66305367
22	Epileptic encephalopathy (HP:0200134)	2.64616478
23	Generalized tonic-clonic seizures (HP:0002069)	2.59316171
24	Visual hallucinations (HP:0002367)	2.59295005
25	Pancreatic cysts (HP:0001737)	2.54123598
26	Choroideremia (HP:0001139)	2.53399445
27	Molar tooth sign on MRI (HP:0002419)	2.51835170
28	Abnormality of midbrain morphology (HP:0002418)	2.51835170
29	Abnormal biliary tract physiology (HP:0012439)	2.50391768
30	Bile duct proliferation (HP:0001408)	2.50391768
31	Drooling (HP:0002307)	2.48513380
32	High anterior hairline (HP:0009890)	2.47231697
33	Dialeptic seizures (HP:0011146)	2.45180809
34	Generalized myoclonic seizures (HP:0002123)	2.43708238
35	Volvulus (HP:0002580)	2.41738569
36	Microvesicular hepatic steatosis (HP:0001414)	2.41238931
37	Excessive salivation (HP:0003781)	2.40343448
38	Neonatal respiratory distress (HP:0002643)	2.37573762
39	Decreased subcutaneous fat (HP:0001002)	2.35649722
40	Colon cancer (HP:0003003)	2.34184281
41	11 pairs of ribs (HP:0000878)	2.33879141
42	Hypothermia (HP:0002045)	2.31169550
43	Abnormality of lateral ventricle (HP:0030047)	2.28631165
44	Febrile seizures (HP:0002373)	2.27032698
45	Status epilepticus (HP:0002133)	2.26900830
46	Abnormality of chromosome segregation (HP:0002916)	2.25762811
47	Neoplasm of the heart (HP:0100544)	2.25682145
48	Lymphangioma (HP:0100764)	2.25372443
49	Pigmentary retinal degeneration (HP:0001146)	2.25310431
50	Combined immunodeficiency (HP:0005387)	2.24511166
51	Genital tract atresia (HP:0001827)	2.24487478
52	Abnormality of the labia minora (HP:0012880)	2.23057201
53	Pachygyria (HP:0001302)	2.19983764
54	Tented upper lip vermilion (HP:0010804)	2.19412237
55	Fair hair (HP:0002286)	2.19365452
56	Congenital stationary night blindness (HP:0007642)	2.17336341
57	Short 1st metacarpal (HP:0010034)	2.15394223
58	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.15394223
59	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.14857783
60	Megalencephaly (HP:0001355)	2.13970435
61	Broad-based gait (HP:0002136)	2.13386238
62	Chronic hepatic failure (HP:0100626)	2.12792974
63	Optic nerve hypoplasia (HP:0000609)	2.11932133
64	Gastrointestinal stroma tumor (HP:0100723)	2.10413055
65	Abolished electroretinogram (ERG) (HP:0000550)	2.08534134
66	Absent speech (HP:0001344)	2.08399635
67	Prominent nose (HP:0000448)	2.07331233
68	Renal hypoplasia (HP:0000089)	2.07279301
69	Facial hemangioma (HP:0000329)	2.06518611
70	3-Methylglutaconic aciduria (HP:0003535)	2.05865542
71	Microglossia (HP:0000171)	2.04761872
72	Short palpebral fissure (HP:0012745)	2.00245443
73	Dyschromatopsia (HP:0007641)	1.98811465
74	Spontaneous hematomas (HP:0007420)	1.98485629
75	Skull defect (HP:0001362)	1.96680832
76	Impaired social interactions (HP:0000735)	1.96654206
77	Abnormal social behavior (HP:0012433)	1.96654206
78	Abnormality of the 1st metacarpal (HP:0010009)	1.93029701
79	Broad alveolar ridges (HP:0000187)	1.92794028
80	Acute necrotizing encephalopathy (HP:0006965)	1.92318650
81	Horseshoe kidney (HP:0000085)	1.91395799
82	Broad ribs (HP:0000885)	1.90981298
83	Clubbing of toes (HP:0100760)	1.90536628
84	True hermaphroditism (HP:0010459)	1.90110995
85	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.88445970
86	Short 4th metacarpal (HP:0010044)	1.88445970
87	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.87101321
88	Spinal muscular atrophy (HP:0007269)	1.85407958
89	Aplastic anemia (HP:0001915)	1.85196018
90	Poor eye contact (HP:0000817)	1.84866837
91	Lymphopenia (HP:0001888)	1.84666798
92	Hypochromic microcytic anemia (HP:0004840)	1.84034394
93	Oligodactyly (hands) (HP:0001180)	1.83394238
94	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.82885754
95	Hemoptysis (HP:0002105)	1.82383580
96	Recurrent sinusitis (HP:0011108)	1.79668328
97	Abnormality of the astrocytes (HP:0100707)	1.79367975
98	Astrocytoma (HP:0009592)	1.79367975
99	Hypoplastic iliac wings (HP:0002866)	1.79162304
100	Abnormality of salivation (HP:0100755)	1.78942204

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	5.01293758
2	CLK1	4.66900459
3	MAPK13	4.34161819
4	CCNB1	4.15957313
5	FRK	2.43007255
6	TAOK3	2.33670170
7	TNK2	2.31869737
8	CAMKK2	2.30694466
9	NTRK3	2.11932185
10	EPHA4	1.96763113
11	PINK1	1.93922641
12	TRIM28	1.91637498
13	SIK2	1.89900706
14	IRAK2	1.85329672
15	GRK6	1.80636063
16	BCR	1.79307975
17	SRPK1	1.75230759
18	UHMK1	1.62260917
19	RPS6KA4	1.54218769
20	CAMK4	1.52056200
21	PRKD3	1.49213071
22	IRAK1	1.47308130
23	ERBB3	1.46960921
24	CDK3	1.42169084
25	VRK1	1.31617658
26	DYRK2	1.28371741
27	SYK	1.26566541
28	STK16	1.19524995
29	PRKCZ	1.13548934
30	DYRK3	1.08778343
31	MAP3K10	1.00514335
32	CAMK1D	0.97261518
33	STK38	0.93346228
34	NUAK1	0.92530896
35	MAPK4	0.91629266
36	ADRBK2	0.90864890
37	PKN1	0.84683650
38	CDC7	0.83476898
39	PRKCE	0.83284667
40	GRK1	0.83179408
41	BTK	0.82246912
42	PRKD2	0.77850161
43	MINK1	0.77254239
44	BLK	0.73339653
45	CAMKK1	0.71385738
46	SGK2	0.70120953
47	YES1	0.69651584
48	CSNK1A1	0.68544500
49	MAP4K1	0.67061521
50	PRKD1	0.66555333
51	STK11	0.64034122
52	PRKCH	0.63736303
53	PLK2	0.63224251
54	NEK2	0.63066254
55	TYK2	0.62930804
56	TAOK1	0.62075368
57	AURKB	0.61079086
58	PLK3	0.60121322
59	CSF1R	0.59697429
60	PRKCB	0.58088259
61	BUB1	0.56747886
62	ATR	0.55138550
63	PDK1	0.54984959
64	BMPR2	0.54753963
65	RIPK4	0.53864224
66	HIPK2	0.53268894
67	VRK2	0.53239594
68	CAMK2B	0.53150588
69	RPS6KA6	0.52737721
70	MAPK7	0.51704480
71	MKNK2	0.50495497
72	NTRK2	0.49962890
73	MAP3K2	0.49076939
74	EPHA3	0.48218948
75	LYN	0.47921478
76	DAPK2	0.47565026
77	MAPKAPK2	0.47518619
78	ROCK1	0.45213658
79	SGK1	0.44903171
80	ILK	0.44439256
81	TXK	0.43915671
82	RPS6KL1	0.43529693
83	RPS6KC1	0.43529693
84	CASK	0.42188611
85	PLK4	0.41575064
86	PAK3	0.40818399
87	ROCK2	0.38984872
88	CAMK2A	0.36537912
89	FES	0.36243844
90	INSRR	0.35912155
91	MAPK8	0.34968696
92	ATM	0.33539619
93	PIK3CG	0.33426517
94	PLK1	0.32878234
95	PRKCQ	0.32565216
96	MAP2K2	0.32435172
97	BRSK2	0.31625277
98	SGK223	0.30590545
99	SGK494	0.30590545
100	PRKACA	0.29851988

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	4.93228314
2	Non-homologous end-joining_Homo sapiens_hsa03450	4.73371355
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.75583858
4	Homologous recombination_Homo sapiens_hsa03440	2.48340771
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.47344411
6	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.38607562
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.13432159
8	Asthma_Homo sapiens_hsa05310	2.02163080
9	Nicotine addiction_Homo sapiens_hsa05033	1.94717617
10	RNA polymerase_Homo sapiens_hsa03020	1.77259481
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.77050366
12	Steroid biosynthesis_Homo sapiens_hsa00100	1.76994800
13	Primary immunodeficiency_Homo sapiens_hsa05340	1.73625834
14	Phototransduction_Homo sapiens_hsa04744	1.68047642
15	Long-term depression_Homo sapiens_hsa04730	1.63674843
16	Glutamatergic synapse_Homo sapiens_hsa04724	1.60668361
17	Circadian entrainment_Homo sapiens_hsa04713	1.60590526
18	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.52735028
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.49818746
20	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.49151734
21	Axon guidance_Homo sapiens_hsa04360	1.44185580
22	Allograft rejection_Homo sapiens_hsa05330	1.43882356
23	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.42534662
24	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.41793566
25	Graft-versus-host disease_Homo sapiens_hsa05332	1.39758244
26	Taste transduction_Homo sapiens_hsa04742	1.36287936
27	Amphetamine addiction_Homo sapiens_hsa05031	1.34645348
28	Fatty acid elongation_Homo sapiens_hsa00062	1.32258040
29	Morphine addiction_Homo sapiens_hsa05032	1.31088528
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.26750426
31	One carbon pool by folate_Homo sapiens_hsa00670	1.22710107
32	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.19560523
33	DNA replication_Homo sapiens_hsa03030	1.18413641
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17578006
35	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.17531699
36	GABAergic synapse_Homo sapiens_hsa04727	1.16441761
37	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.11590131
38	Fatty acid metabolism_Homo sapiens_hsa01212	1.09125666
39	Cocaine addiction_Homo sapiens_hsa05030	1.08699808
40	RNA degradation_Homo sapiens_hsa03018	1.06441970
41	Renin secretion_Homo sapiens_hsa04924	1.03320550
42	Proteasome_Homo sapiens_hsa03050	0.98733241
43	Propanoate metabolism_Homo sapiens_hsa00640	0.94693726
44	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.93618842
45	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.87070765
46	Type I diabetes mellitus_Homo sapiens_hsa04940	0.80324462
47	Parkinsons disease_Homo sapiens_hsa05012	0.79909585
48	Salivary secretion_Homo sapiens_hsa04970	0.76070750
49	Olfactory transduction_Homo sapiens_hsa04740	0.75955308
50	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.75569679
51	Serotonergic synapse_Homo sapiens_hsa04726	0.74989874
52	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.74765555
53	Long-term potentiation_Homo sapiens_hsa04720	0.72844347
54	African trypanosomiasis_Homo sapiens_hsa05143	0.71762282
55	Pyrimidine metabolism_Homo sapiens_hsa00240	0.70146502
56	RNA transport_Homo sapiens_hsa03013	0.69635652
57	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.67971683
58	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.67410686
59	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.67095860
60	Antigen processing and presentation_Homo sapiens_hsa04612	0.65870649
61	Spliceosome_Homo sapiens_hsa03040	0.65653577
62	Cholinergic synapse_Homo sapiens_hsa04725	0.63232395
63	Calcium signaling pathway_Homo sapiens_hsa04020	0.62151326
64	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.61741906
65	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.59221582
66	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.58303165
67	mTOR signaling pathway_Homo sapiens_hsa04150	0.56056801
68	Dopaminergic synapse_Homo sapiens_hsa04728	0.55135482
69	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.54801529
70	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.53552522
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.49509094
72	Linoleic acid metabolism_Homo sapiens_hsa00591	0.48481920
73	Wnt signaling pathway_Homo sapiens_hsa04310	0.47486876
74	Gap junction_Homo sapiens_hsa04540	0.47321923
75	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.46270992
76	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.45861373
77	Insulin secretion_Homo sapiens_hsa04911	0.45452793
78	Purine metabolism_Homo sapiens_hsa00230	0.45126692
79	Gastric acid secretion_Homo sapiens_hsa04971	0.42727838
80	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.41324434
81	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.41199171
82	Caffeine metabolism_Homo sapiens_hsa00232	0.40484418
83	Alzheimers disease_Homo sapiens_hsa05010	0.40298425
84	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.39611692
85	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.38800370
86	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.38318051
87	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.37508725
88	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.37248443
89	Oocyte meiosis_Homo sapiens_hsa04114	0.36346491
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.35604481
91	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.34538117
92	Oxidative phosphorylation_Homo sapiens_hsa00190	0.31765649
93	Mismatch repair_Homo sapiens_hsa03430	0.31700082
94	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.31092302
95	Base excision repair_Homo sapiens_hsa03410	0.30370162
96	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.29788892
97	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.29329368
98	Rheumatoid arthritis_Homo sapiens_hsa05323	0.26654984
99	Ras signaling pathway_Homo sapiens_hsa04014	0.25830731
100	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.24099633

POU5F1P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »