POU5F2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.47342368
2fusion of sperm to egg plasma membrane (GO:0007342)7.70813762
3sperm motility (GO:0030317)7.46150677
4acrosome reaction (GO:0007340)7.13430123
5piRNA metabolic process (GO:0034587)7.10926058
6axonemal dynein complex assembly (GO:0070286)6.60649674
7sperm-egg recognition (GO:0035036)6.60601091
8multicellular organism reproduction (GO:0032504)6.43761490
9motile cilium assembly (GO:0044458)6.37170940
10acrosome assembly (GO:0001675)6.32233651
11binding of sperm to zona pellucida (GO:0007339)6.11024471
12male meiosis (GO:0007140)6.10875985
13cell-cell recognition (GO:0009988)6.08945239
14neutrophil activation involved in immune response (GO:0002283)5.99381348
15plasma membrane fusion (GO:0045026)5.88189922
16epithelial cilium movement (GO:0003351)5.46936790
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.44967360
18spermatid development (GO:0007286)5.14953461
19positive regulation of prostaglandin secretion (GO:0032308)5.05013417
20reproduction (GO:0000003)4.91369779
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.88051951
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.88051951
23cilium movement (GO:0003341)4.71480004
24DNA methylation involved in gamete generation (GO:0043046)4.59161669
25synaptonemal complex organization (GO:0070193)4.53430187
26sodium-independent organic anion transport (GO:0043252)4.51068623
27regulation of prostaglandin secretion (GO:0032306)4.39516712
28tryptophan catabolic process (GO:0006569)4.35882249
29indole-containing compound catabolic process (GO:0042436)4.35882249
30indolalkylamine catabolic process (GO:0046218)4.35882249
31antigen processing and presentation of endogenous antigen (GO:0019883)4.35412364
32positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.31310880
33single fertilization (GO:0007338)4.28279622
34positive regulation of icosanoid secretion (GO:0032305)4.15232108
35detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.14451862
36synaptonemal complex assembly (GO:0007130)4.14090185
37neural tube formation (GO:0001841)4.14059950
38cell wall macromolecule metabolic process (GO:0044036)4.09056914
39cell wall macromolecule catabolic process (GO:0016998)4.09056914
40positive regulation of gamma-delta T cell activation (GO:0046645)4.08237136
41kynurenine metabolic process (GO:0070189)4.05716115
42behavioral response to nicotine (GO:0035095)4.05057807
43indolalkylamine metabolic process (GO:0006586)4.04751307
44sperm capacitation (GO:0048240)4.02935194
45male meiosis I (GO:0007141)4.00636499
46protein K11-linked deubiquitination (GO:0035871)3.84656130
47regulation of cilium movement (GO:0003352)3.77303419
48photoreceptor cell maintenance (GO:0045494)3.72896458
49tryptophan metabolic process (GO:0006568)3.68528734
50L-fucose catabolic process (GO:0042355)3.65271868
51fucose catabolic process (GO:0019317)3.65271868
52L-fucose metabolic process (GO:0042354)3.65271868
53meiotic cell cycle (GO:0051321)3.63649414
54detection of light stimulus involved in sensory perception (GO:0050962)3.60994440
55detection of light stimulus involved in visual perception (GO:0050908)3.60994440
56organic cation transport (GO:0015695)3.58988351
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.58110362
58signal peptide processing (GO:0006465)3.56211618
59establishment of protein localization to Golgi (GO:0072600)3.55909364
60positive regulation of natural killer cell differentiation (GO:0032825)3.53814643
61neutrophil activation (GO:0042119)3.53281881
62fertilization (GO:0009566)3.47329416
63meiotic nuclear division (GO:0007126)3.45709312
64calcium ion-dependent exocytosis (GO:0017156)3.40570920
65ribosomal small subunit assembly (GO:0000028)3.39150868
66prenylation (GO:0097354)3.35969570
67protein prenylation (GO:0018342)3.35969570
68cellular ketone body metabolic process (GO:0046950)3.33843191
69negative regulation of inclusion body assembly (GO:0090084)3.28662364
70regulation of icosanoid secretion (GO:0032303)3.27405872
71positive regulation of fatty acid transport (GO:2000193)3.26779205
72spermatogenesis (GO:0007283)3.25740838
73male gamete generation (GO:0048232)3.24365008
74positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.23510368
75meiosis I (GO:0007127)3.22509207
76leukocyte degranulation (GO:0043299)3.20198634
77monoubiquitinated protein deubiquitination (GO:0035520)3.14068805
78DNA double-strand break processing (GO:0000729)3.13000951
79positive regulation of developmental pigmentation (GO:0048087)3.12132524
80mitotic sister chromatid cohesion (GO:0007064)3.11895030
81mast cell activation (GO:0045576)3.11385536
82retinal cone cell development (GO:0046549)3.09707083
83granulocyte activation (GO:0036230)3.09293676
84ventricular system development (GO:0021591)3.04705741
85ketone body metabolic process (GO:1902224)3.03594528
86response to pheromone (GO:0019236)3.02923982
87reflex (GO:0060004)3.01990692
88positive regulation of protein homodimerization activity (GO:0090073)3.01619700
89cellular response to interferon-beta (GO:0035458)2.99413752
90DNA deamination (GO:0045006)2.97766927
91regulation of defense response to virus by host (GO:0050691)2.96835479
92cilium morphogenesis (GO:0060271)2.96194877
93gamete generation (GO:0007276)2.95854332
94cellular response to exogenous dsRNA (GO:0071360)2.93767860
95positive regulation of interleukin-17 production (GO:0032740)2.93077954
96regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.92698116
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.87446434
98protein localization to cilium (GO:0061512)2.87221011
99regulation of hippo signaling (GO:0035330)2.87071643
100rRNA catabolic process (GO:0016075)2.85456828
101seminiferous tubule development (GO:0072520)2.85130508
102cilium organization (GO:0044782)2.85010359
103reciprocal meiotic recombination (GO:0007131)2.84518098
104reciprocal DNA recombination (GO:0035825)2.84518098
105interleukin-1-mediated signaling pathway (GO:0070498)2.83779389
106positive regulation of macrophage activation (GO:0043032)2.83730327
107indole-containing compound metabolic process (GO:0042430)2.82396380
108negative regulation of mast cell activation (GO:0033004)2.81426577
109cellular process involved in reproduction in multicellular organism (GO:0022412)2.81318747
110regulation of pigment cell differentiation (GO:0050932)2.81149997
111chromosome organization involved in meiosis (GO:0070192)2.81071279
112negative regulation of erythrocyte differentiation (GO:0045647)2.80958700
113response to interferon-beta (GO:0035456)2.80224557
114double-strand break repair via homologous recombination (GO:0000724)2.80131585
115protein K48-linked deubiquitination (GO:0071108)2.79904975
116benzene-containing compound metabolic process (GO:0042537)2.79578927
117replication fork processing (GO:0031297)2.79461346
118regulation of sarcomere organization (GO:0060297)2.78655033
119recombinational repair (GO:0000725)2.78466415
120antigen processing and presentation via MHC class Ib (GO:0002475)2.78466148
121GTP biosynthetic process (GO:0006183)2.78442042
122Peyers patch development (GO:0048541)2.77978750
123mucosal-associated lymphoid tissue development (GO:0048537)2.77978750
124nonmotile primary cilium assembly (GO:0035058)2.77572414
125protein targeting to Golgi (GO:0000042)2.76802096
126myeloid cell activation involved in immune response (GO:0002275)2.76203069
127auditory receptor cell stereocilium organization (GO:0060088)2.75303847
128natural killer cell mediated immunity (GO:0002228)2.74883988
129natural killer cell mediated cytotoxicity (GO:0042267)2.74883988
130histone H2A acetylation (GO:0043968)2.74643281
131cilium assembly (GO:0042384)2.73138596
132cellular biogenic amine catabolic process (GO:0042402)2.72810638
133amine catabolic process (GO:0009310)2.72810638
134cell recognition (GO:0008037)2.72706455
135valine metabolic process (GO:0006573)2.72342056
136positive regulation of oligodendrocyte differentiation (GO:0048714)2.71631875
137RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.71355279
138regulation of glucokinase activity (GO:0033131)2.71017219
139regulation of hexokinase activity (GO:1903299)2.71017219
140response to type I interferon (GO:0034340)2.70649782
141negative regulation of translation, ncRNA-mediated (GO:0040033)2.70019666
142regulation of translation, ncRNA-mediated (GO:0045974)2.70019666
143negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.70019666
144detection of mechanical stimulus involved in sensory perception (GO:0050974)2.70004771
145polyol catabolic process (GO:0046174)2.69366829
146germ cell development (GO:0007281)2.68353511
147lactate metabolic process (GO:0006089)2.67529299
148genitalia morphogenesis (GO:0035112)2.66947924
149respiratory chain complex IV assembly (GO:0008535)2.66591218
150negative regulation of viral genome replication (GO:0045071)2.66440149
151behavioral response to ethanol (GO:0048149)2.65796603
152oxidative demethylation (GO:0070989)2.65484661
153photoreceptor cell development (GO:0042461)2.64544706
154platelet dense granule organization (GO:0060155)2.63083799
155nucleoside diphosphate phosphorylation (GO:0006165)2.62374870
156microtubule anchoring (GO:0034453)2.62246588
157regulation of meiosis I (GO:0060631)2.62225925
158positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.61607808
159UDP-N-acetylglucosamine metabolic process (GO:0006047)2.61480491
160regulation of RIG-I signaling pathway (GO:0039535)2.61241414
161sulfation (GO:0051923)2.61179417
162gamma-aminobutyric acid transport (GO:0015812)2.59525775
163positive regulation of B cell differentiation (GO:0045579)2.59461734
164centriole replication (GO:0007099)2.59230501
165preassembly of GPI anchor in ER membrane (GO:0016254)2.58403173
166NAD biosynthetic process (GO:0009435)2.58211330
167kidney morphogenesis (GO:0060993)2.57013238
168tachykinin receptor signaling pathway (GO:0007217)2.56339671
169positive regulation of fatty acid biosynthetic process (GO:0045723)2.55609381
170type I interferon signaling pathway (GO:0060337)2.55547159
171cellular response to type I interferon (GO:0071357)2.55547159
172axoneme assembly (GO:0035082)2.55243348
173regulation of action potential (GO:0098900)2.53325856
174regulation of macrophage derived foam cell differentiation (GO:0010743)2.53129426
175DNA demethylation (GO:0080111)2.53003736
176negative regulation of DNA-dependent DNA replication (GO:2000104)2.52981738
177amino acid salvage (GO:0043102)2.52803540
178L-methionine salvage (GO:0071267)2.52803540
179L-methionine biosynthetic process (GO:0071265)2.52803540
180positive regulation of defense response to virus by host (GO:0002230)2.50483307
181thyroid hormone metabolic process (GO:0042403)2.49899601
182G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49492794
183intraciliary transport (GO:0042073)2.48263808
184protein localization to Golgi apparatus (GO:0034067)2.46542047
185retrograde transport, vesicle recycling within Golgi (GO:0000301)2.45603973
186inner ear receptor stereocilium organization (GO:0060122)2.44124665
187C4-dicarboxylate transport (GO:0015740)2.43897066
188embryonic epithelial tube formation (GO:0001838)2.43798701
189negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43712517
190protein K63-linked deubiquitination (GO:0070536)2.43399600

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.22324539
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.82292008
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.12444778
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.07187822
5GBX2_23144817_ChIP-Seq_PC3_Human3.36111292
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.20011394
7ZNF274_21170338_ChIP-Seq_K562_Hela3.10423756
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.06631461
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.91855218
10IGF1R_20145208_ChIP-Seq_DFB_Human2.85085227
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.82118534
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.69751799
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.58808830
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56016042
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.40254741
16VDR_22108803_ChIP-Seq_LS180_Human2.35303266
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.30873463
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22731844
19EWS_26573619_Chip-Seq_HEK293_Human2.22229445
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.20786587
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.20585562
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18521146
23P300_19829295_ChIP-Seq_ESCs_Human2.14545348
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.09928969
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.09358855
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.01146046
27SCL_19346495_ChIP-Seq_HPC-7_Human1.99926697
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.94433453
29TAF15_26573619_Chip-Seq_HEK293_Human1.93709157
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92780161
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92496693
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89192228
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.89100385
34EZH2_22144423_ChIP-Seq_EOC_Human1.82934541
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.80782825
36SMAD4_21799915_ChIP-Seq_A2780_Human1.80644700
37PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.80405981
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.77362637
39STAT3_23295773_ChIP-Seq_U87_Human1.77024098
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72324421
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.69890821
42GATA1_26923725_Chip-Seq_HPCs_Mouse1.69249839
43* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65716268
44BCAT_22108803_ChIP-Seq_LS180_Human1.65637360
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.64455563
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.63702007
47SPI1_23547873_ChIP-Seq_NB4_Human1.62748105
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62742912
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60806664
50TCF4_23295773_ChIP-Seq_U87_Human1.59905955
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57183727
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.56826229
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56580661
54* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55977364
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54942797
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54672215
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.53305401
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49685036
59AR_25329375_ChIP-Seq_VCAP_Human1.48455091
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47353928
61PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47311212
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47115973
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.45481915
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44635959
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43994586
66* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41126938
67* TCF4_22108803_ChIP-Seq_LS180_Human1.40380160
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.40049952
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39565907
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38796635
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38712452
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38404337
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36922698
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.31753760
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.30808133
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.30663894
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30332277
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30213083
79TP53_22573176_ChIP-Seq_HFKS_Human1.29855427
80RUNX2_22187159_ChIP-Seq_PCA_Human1.28870880
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.28450454
82AR_21572438_ChIP-Seq_LNCaP_Human1.27407237
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26488813
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.25805361
85MYB_26560356_Chip-Seq_TH2_Human1.25042379
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24975964
87IRF1_19129219_ChIP-ChIP_H3396_Human1.24971133
88NANOG_19829295_ChIP-Seq_ESCs_Human1.24527124
89SOX2_19829295_ChIP-Seq_ESCs_Human1.24527124
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.23709714
91TP53_16413492_ChIP-PET_HCT116_Human1.22274413
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22128162
93CDX2_22108803_ChIP-Seq_LS180_Human1.21833256
94ER_23166858_ChIP-Seq_MCF-7_Human1.21686603
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20620961
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20381514
97NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20217931
98VDR_24787735_ChIP-Seq_THP-1_Human1.20003384
99FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19175474
100OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17919038
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.16571549
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.15811632
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15546223
104GATA3_21867929_ChIP-Seq_TH1_Mouse1.15126180
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13358789
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13358789
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13038262
108SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13006329
109P53_22387025_ChIP-Seq_ESCs_Mouse1.12871218
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11061907
111VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10179013
112* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09801190
113* FOXA1_25329375_ChIP-Seq_VCAP_Human1.09801190
114NANOG_18555785_Chip-Seq_ESCs_Mouse1.09779262
115RUNX1_22412390_ChIP-Seq_EML_Mouse1.09288557
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08505539
117HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08085570
118ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08063610
119CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07451151
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07439200
121WDR5_24793694_ChIP-Seq_LNCAP_Human1.06650721
122RUNX1_27457419_Chip-Seq_LIVER_Mouse1.06647583
123KLF4_18555785_Chip-Seq_ESCs_Mouse1.05326287
124VDR_24763502_ChIP-Seq_THP-1_Human1.05178703
125* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05168860
126VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05061457
127STAT3_18555785_Chip-Seq_ESCs_Mouse1.04486753
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04291838
129SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03753871
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03392812
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03310727
132SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03201125
133MYB_26560356_Chip-Seq_TH1_Human1.02055098
134POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01955634
135SOX2_18555785_Chip-Seq_ESCs_Mouse1.01414526
136ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99629866
137SOX2_21211035_ChIP-Seq_LN229_Gbm0.97848109
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.96897294
139P300_18555785_Chip-Seq_ESCs_Mouse0.95806952
140PU1_27457419_Chip-Seq_LIVER_Mouse0.94319719
141NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93713380
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93689554
143FUS_26573619_Chip-Seq_HEK293_Human0.93640371
144OCT4_18555785_Chip-Seq_ESCs_Mouse0.93449690
145CTCF_18555785_Chip-Seq_ESCs_Mouse0.92520009
146EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91987805
147SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90894477
148ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90370690
149GATA3_26560356_Chip-Seq_TH2_Human0.90276119
150RUNX_20019798_ChIP-Seq_JUKART_Human0.90171276
151ETS1_22383799_ChIP-Seq_G1ME_Mouse0.89711743
152IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87904288
153CBP_20019798_ChIP-Seq_JUKART_Human0.87904288
154EZH2_27294783_Chip-Seq_NPCs_Mouse0.87475209
155SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87193952
156ESRRB_18555785_Chip-Seq_ESCs_Mouse0.86574385
157GATA3_27048872_Chip-Seq_THYMUS_Human0.85896910
158KDM2B_26808549_Chip-Seq_REH_Human0.85071339
159ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84784023
160NMYC_18555785_Chip-Seq_ESCs_Mouse0.84689481
161STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.84671826
162TDRD3_21172665_ChIP-Seq_MCF-7_Human0.84267521
163CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84174330
164BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83982359
165SMAD1_18555785_Chip-Seq_ESCs_Mouse0.83131712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.50016013
2MP0001835_abnormal_antigen_presentation3.93503763
3MP0008877_abnormal_DNA_methylation3.74865479
4MP0008057_abnormal_DNA_replication3.10511785
5MP0003724_increased_susceptibility_to3.07954328
6* MP0003698_abnormal_male_reproductive2.68143698
7MP0005551_abnormal_eye_electrophysiolog2.63414655
8MP0000685_abnormal_immune_system2.61999171
9MP0009278_abnormal_bone_marrow2.48022145
10MP0001929_abnormal_gametogenesis2.46326215
11MP0002102_abnormal_ear_morphology2.42508172
12MP0009785_altered_susceptibility_to2.41253606
13MP0005397_hematopoietic_system_phenotyp2.34840749
14MP0001545_abnormal_hematopoietic_system2.34840749
15MP0002419_abnormal_innate_immunity2.28350394
16MP0005025_abnormal_response_to2.23565056
17MP0002148_abnormal_hypersensitivity_rea2.23353896
18MP0001790_abnormal_immune_system2.22201689
19MP0005387_immune_system_phenotype2.22201689
20MP0003787_abnormal_imprinting2.21699041
21MP0001501_abnormal_sleep_pattern2.15391010
22MP0001968_abnormal_touch/_nociception2.14943846
23MP0000372_irregular_coat_pigmentation2.14707144
24MP0004742_abnormal_vestibular_system2.14651095
25MP0005671_abnormal_response_to2.10085759
26MP0006072_abnormal_retinal_apoptosis2.09661616
27MP0005253_abnormal_eye_physiology2.08005022
28MP0000427_abnormal_hair_cycle2.06385701
29MP0005174_abnormal_tail_pigmentation2.03034646
30MP0003646_muscle_fatigue1.97939466
31MP0002736_abnormal_nociception_after1.95568769
32MP0005379_endocrine/exocrine_gland_phen1.94424054
33MP0002723_abnormal_immune_serum1.90531268
34MP0005000_abnormal_immune_tolerance1.90490109
35MP0004043_abnormal_pH_regulation1.88870481
36MP0004147_increased_porphyrin_level1.87680673
37MP0002452_abnormal_antigen_presenting1.85833569
38MP0001819_abnormal_immune_cell1.84227897
39MP0002837_dystrophic_cardiac_calcinosis1.82862881
40MP0002420_abnormal_adaptive_immunity1.82755376
41MP0001800_abnormal_humoral_immune1.81587158
42MP0002638_abnormal_pupillary_reflex1.76711334
43MP0003183_abnormal_peptide_metabolism1.73987567
44MP0001348_abnormal_lacrimal_gland1.69154400
45MP0003136_yellow_coat_color1.64203791
46MP0003436_decreased_susceptibility_to1.62662093
47MP0003763_abnormal_thymus_physiology1.58375465
48MP0002210_abnormal_sex_determination1.56827682
49MP0002938_white_spotting1.54912767
50MP0002398_abnormal_bone_marrow1.52650044
51MP0005645_abnormal_hypothalamus_physiol1.51067578
52MP0004808_abnormal_hematopoietic_stem1.48400745
53MP0000569_abnormal_digit_pigmentation1.48258056
54MP0008875_abnormal_xenobiotic_pharmacok1.46891205
55MP0001486_abnormal_startle_reflex1.44845519
56MP0002166_altered_tumor_susceptibility1.42746770
57MP0002735_abnormal_chemical_nociception1.41548610
58MP0000716_abnormal_immune_system1.40410054
59MP0004142_abnormal_muscle_tone1.39288569
60MP0005075_abnormal_melanosome_morpholog1.30429493
61MP0002653_abnormal_ependyma_morphology1.28898753
62MP0001485_abnormal_pinna_reflex1.28205221
63MP0003252_abnormal_bile_duct1.27985914
64MP0001853_heart_inflammation1.27700891
65MP0006276_abnormal_autonomic_nervous1.26695262
66* MP0002161_abnormal_fertility/fecundity1.26528666
67MP0006292_abnormal_olfactory_placode1.24055809
68MP0002928_abnormal_bile_duct1.23816304
69MP0009046_muscle_twitch1.22644417
70MP0009764_decreased_sensitivity_to1.22213050
71MP0003866_abnormal_defecation1.20036723
72MP0001145_abnormal_male_reproductive1.19801021
73MP0005670_abnormal_white_adipose1.19532620
74MP0004145_abnormal_muscle_electrophysio1.19001469
75MP0000703_abnormal_thymus_morphology1.17783045
76MP0003880_abnormal_central_pattern1.17648153
77MP0000631_abnormal_neuroendocrine_gland1.16974047
78MP0002405_respiratory_system_inflammati1.15413883
79MP0005386_behavior/neurological_phenoty1.13767094
80MP0004924_abnormal_behavior1.13767094
81MP0002429_abnormal_blood_cell1.12728824
82MP0004215_abnormal_myocardial_fiber1.12328200
83MP0000689_abnormal_spleen_morphology1.11940285
84MP0002722_abnormal_immune_system1.11551398
85MP0002277_abnormal_respiratory_mucosa1.10645995
86MP0005409_darkened_coat_color1.05571566
87MP0000015_abnormal_ear_pigmentation1.05211384
88MP0004381_abnormal_hair_follicle1.02765406
89MP0008058_abnormal_DNA_repair1.02075550
90MP0005389_reproductive_system_phenotype1.00508585
91MP0000920_abnormal_myelination1.00402857
92MP0001970_abnormal_pain_threshold1.00352557
93MP0002572_abnormal_emotion/affect_behav1.00275107
94MP0005195_abnormal_posterior_eye0.99889632
95MP0001845_abnormal_inflammatory_respons0.99844464
96MP0000465_gastrointestinal_hemorrhage0.99801496
97MP0002234_abnormal_pharynx_morphology0.96122194
98MP0001764_abnormal_homeostasis0.95739143
99MP0008872_abnormal_physiological_respon0.95610998
100MP0002138_abnormal_hepatobiliary_system0.95251182
101MP0005085_abnormal_gallbladder_physiolo0.95071897
102MP0002067_abnormal_sensory_capabilities0.94552877
103MP0003121_genomic_imprinting0.93507690
104MP0002006_tumorigenesis0.93377695
105MP0000653_abnormal_sex_gland0.93192705
106MP0006054_spinal_hemorrhage0.92276779
107MP0010155_abnormal_intestine_physiology0.92149917
108MP0005167_abnormal_blood-brain_barrier0.91836671
109MP0002229_neurodegeneration0.91192148
110MP0009745_abnormal_behavioral_response0.91029865
111MP0001324_abnormal_eye_pigmentation0.90519083
112MP0002557_abnormal_social/conspecific_i0.90477699
113MP0005464_abnormal_platelet_physiology0.90270733
114MP0000538_abnormal_urinary_bladder0.89210638
115MP0005084_abnormal_gallbladder_morpholo0.89067088
116MP0002272_abnormal_nervous_system0.88582006
117MP0000230_abnormal_systemic_arterial0.88567177
118MP0002751_abnormal_autonomic_nervous0.88229058
119MP0000647_abnormal_sebaceous_gland0.87974107
120MP0002733_abnormal_thermal_nociception0.87370196
121MP0008469_abnormal_protein_level0.83780590
122MP0010678_abnormal_skin_adnexa0.83164975
123MP0002877_abnormal_melanocyte_morpholog0.82702957
124MP0005646_abnormal_pituitary_gland0.81953547
125MP0003950_abnormal_plasma_membrane0.81662664
126MP0004133_heterotaxia0.80061392
127MP0010386_abnormal_urinary_bladder0.79534981
128MP0006082_CNS_inflammation0.79030294
129MP0002095_abnormal_skin_pigmentation0.78250884
130MP0002064_seizures0.78101393
131MP0008995_early_reproductive_senescence0.77702673
132MP0002734_abnormal_mechanical_nocicepti0.77191294
133MP0003890_abnormal_embryonic-extraembry0.76847192
134MP0001873_stomach_inflammation0.76280878
135MP0001533_abnormal_skeleton_physiology0.76112193
136MP0003718_maternal_effect0.75519124
137MP0003635_abnormal_synaptic_transmissio0.75399571
138MP0003045_fibrosis0.75256169
139MP0003878_abnormal_ear_physiology0.75153218
140MP0005377_hearing/vestibular/ear_phenot0.75153218
141MP0000858_altered_metastatic_potential0.74751426
142MP0002168_other_aberrant_phenotype0.74252895
143MP0001919_abnormal_reproductive_system0.73878286
144MP0005171_absent_coat_pigmentation0.72812227
145MP0008775_abnormal_heart_ventricle0.72386553
146MP0002090_abnormal_vision0.72274846
147MP0005166_decreased_susceptibility_to0.71917181
148MP0002752_abnormal_somatic_nervous0.71474961
149MP0001851_eye_inflammation0.71463947
150MP0009763_increased_sensitivity_to0.70566505
151MP0001984_abnormal_olfaction0.70487257
152MP0002163_abnormal_gland_morphology0.69968180
153MP0004134_abnormal_chest_morphology0.69640820
154MP0002876_abnormal_thyroid_physiology0.69560249
155MP0003195_calcinosis0.67039755
156MP0001765_abnormal_ion_homeostasis0.66954415
157MP0000383_abnormal_hair_follicle0.65402341
158MP0001986_abnormal_taste_sensitivity0.64915692
159MP0005310_abnormal_salivary_gland0.64576981
160MP0002693_abnormal_pancreas_physiology0.63571924
161MP0002160_abnormal_reproductive_system0.63231553
162MP0003191_abnormal_cellular_cholesterol0.61794077
163MP0008007_abnormal_cellular_replicative0.61687144
164MP0003186_abnormal_redox_activity0.60251950
165MP0004270_analgesia0.54418283
166MP0004885_abnormal_endolymph0.52850498
167MP0004947_skin_inflammation0.52313299
168MP0010094_abnormal_chromosome_stability0.51040436

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.94072355
2Absent/shortened dynein arms (HP:0200106)8.40657146
3Dynein arm defect of respiratory motile cilia (HP:0012255)8.40657146
4Abnormal respiratory motile cilium physiology (HP:0012261)6.04699196
5Abnormal respiratory epithelium morphology (HP:0012253)5.83508016
6Abnormal respiratory motile cilium morphology (HP:0005938)5.83508016
7Nasal polyposis (HP:0100582)5.76339284
8Rhinitis (HP:0012384)5.27370978
9Abnormal ciliary motility (HP:0012262)5.06627302
10Abnormality of the nasal mucosa (HP:0000433)4.81061193
11Pancreatic cysts (HP:0001737)4.67146551
12Pancreatic fibrosis (HP:0100732)4.23326369
13True hermaphroditism (HP:0010459)4.14553058
14Chronic bronchitis (HP:0004469)4.09767529
15Bronchitis (HP:0012387)3.95327132
16Recurrent bronchitis (HP:0002837)3.85700200
17Hyperventilation (HP:0002883)3.83438429
18Bronchiectasis (HP:0002110)3.80759611
19Molar tooth sign on MRI (HP:0002419)3.72209773
20Chronic otitis media (HP:0000389)3.64108187
21Infertility (HP:0000789)3.60553367
22Recurrent abscess formation (HP:0002722)3.52606242
23Gaze-evoked nystagmus (HP:0000640)3.48000536
24Nephronophthisis (HP:0000090)3.39454484
25Recurrent bacterial skin infections (HP:0005406)3.39174347
26Congenital stationary night blindness (HP:0007642)3.38673527
27Thrombocytosis (HP:0001894)3.27402683
28Chronic sinusitis (HP:0011109)3.11840601
29Nonprogressive disorder (HP:0003680)3.01686879
30Elevated erythrocyte sedimentation rate (HP:0003565)2.98420748
31Attenuation of retinal blood vessels (HP:0007843)2.97340625
32Chronic hepatic failure (HP:0100626)2.96398933
33Recurrent sinusitis (HP:0011108)2.92693100
34Cystic liver disease (HP:0006706)2.84197823
35Gait imbalance (HP:0002141)2.75541251
36Congenital primary aphakia (HP:0007707)2.74865844
37Genetic anticipation (HP:0003743)2.73740391
38Eczematoid dermatitis (HP:0000976)2.71212366
39Type II lissencephaly (HP:0007260)2.67497192
40Abolished electroretinogram (ERG) (HP:0000550)2.67479041
41Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.66408205
42Fair hair (HP:0002286)2.64903625
43Abnormality of the renal cortex (HP:0011035)2.64023795
44Inability to walk (HP:0002540)2.62415502
45Recurrent otitis media (HP:0000403)2.61795607
46Fatigue (HP:0012378)2.58819590
47Absent speech (HP:0001344)2.57227468
48Progressive cerebellar ataxia (HP:0002073)2.56408917
49Abnormality of the renal medulla (HP:0100957)2.56099378
50Poor head control (HP:0002421)2.54967835
51Absent frontal sinuses (HP:0002688)2.50872412
52Hypergammaglobulinemia (HP:0010702)2.50468584
53Nephrogenic diabetes insipidus (HP:0009806)2.46069161
54Stomach cancer (HP:0012126)2.45353440
55Microvesicular hepatic steatosis (HP:0001414)2.44394198
56Aplasia/Hypoplasia of the tongue (HP:0010295)2.43287349
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.42468472
58Vacuolated lymphocytes (HP:0001922)2.39902906
59Weak cry (HP:0001612)2.36649688
60Congenital hepatic fibrosis (HP:0002612)2.36526790
61Genital tract atresia (HP:0001827)2.34894348
62Febrile seizures (HP:0002373)2.32353168
63Furrowed tongue (HP:0000221)2.31260188
64Keratoconus (HP:0000563)2.31232820
65Increased corneal curvature (HP:0100692)2.31232820
66Recurrent gram-negative bacterial infections (HP:0005420)2.30961308
67Gonadotropin excess (HP:0000837)2.30942778
68Polydipsia (HP:0001959)2.30313835
69Abnormal drinking behavior (HP:0030082)2.30313835
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29516891
71Abnormality of alanine metabolism (HP:0010916)2.29516891
72Hyperalaninemia (HP:0003348)2.29516891
73Broad-based gait (HP:0002136)2.29305485
74Centrally nucleated skeletal muscle fibers (HP:0003687)2.28019628
75Widely spaced teeth (HP:0000687)2.25831665
76Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.24739095
77Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23383273
78Autoimmune thrombocytopenia (HP:0001973)2.22180819
79Increased IgM level (HP:0003496)2.22062310
80Congenital sensorineural hearing impairment (HP:0008527)2.21849868
81Vaginal atresia (HP:0000148)2.21044531
82Abnormal rod and cone electroretinograms (HP:0008323)2.16082449
83Sclerocornea (HP:0000647)2.15349284
84Clumsiness (HP:0002312)2.14161801
85Cerebellar dysplasia (HP:0007033)2.12041564
86Male pseudohermaphroditism (HP:0000037)2.11566607
87Postaxial foot polydactyly (HP:0001830)2.09359018
88Myositis (HP:0100614)2.09140581
89Abnormality of the vasculature of the conjunctiva (HP:0008054)2.08724798
90Bulbar palsy (HP:0001283)2.07971510
91Bony spicule pigmentary retinopathy (HP:0007737)2.07824945
92Constricted visual fields (HP:0001133)2.07729967
93Generalized hypopigmentation of hair (HP:0011358)2.06943983
94Poor coordination (HP:0002370)2.06704920
95Hypothermia (HP:0002045)2.05724119
96Recurrent fungal infections (HP:0002841)2.05682024
97Renal cortical cysts (HP:0000803)2.04184398
98Abnormal delayed hypersensitivity skin test (HP:0002963)2.01393814
99Decreased central vision (HP:0007663)2.00953803
100Abnormality of macrophages (HP:0004311)1.99583084
101Volvulus (HP:0002580)1.98983447
102High pitched voice (HP:0001620)1.98307725
103Anhidrosis (HP:0000970)1.96733665
104Gingivitis (HP:0000230)1.95554026
105Abnormality of cells of the erythroid lineage (HP:0012130)1.94477138
106Large for gestational age (HP:0001520)1.94315338
107Neoplasm of the tracheobronchial system (HP:0100552)1.94197017
108Tubular atrophy (HP:0000092)1.94146261
109Anencephaly (HP:0002323)1.93513720
110Methylmalonic acidemia (HP:0002912)1.91921087
111Lissencephaly (HP:0001339)1.89493367
112Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87196369
113Tubulointerstitial abnormality (HP:0001969)1.87173986
114Mediastinal lymphadenopathy (HP:0100721)1.86895182
115Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86861238
11611 pairs of ribs (HP:0000878)1.86152877
117Intestinal atresia (HP:0011100)1.85740511
118Asplenia (HP:0001746)1.84824688
119Astigmatism (HP:0000483)1.83720676
120Vasculitis (HP:0002633)1.83327499
121Polyuria (HP:0000103)1.82410964
122Chronic obstructive pulmonary disease (HP:0006510)1.80802877
123Obstructive lung disease (HP:0006536)1.80802877
124Hemiparesis (HP:0001269)1.80525649
125Abnormality of the frontal sinuses (HP:0002687)1.80189087
126Exertional dyspnea (HP:0002875)1.79320924
127Tubulointerstitial nephritis (HP:0001970)1.78808877
128Decreased circulating renin level (HP:0003351)1.78461257
129Medial flaring of the eyebrow (HP:0010747)1.78222700
130Abnormal number of erythroid precursors (HP:0012131)1.78129987
131Recurrent viral infections (HP:0004429)1.77735272
132Bile duct proliferation (HP:0001408)1.77202589
133Abnormal biliary tract physiology (HP:0012439)1.77202589
134Postaxial hand polydactyly (HP:0001162)1.77143946
135Chorioretinal atrophy (HP:0000533)1.76494505
136Focal seizures (HP:0007359)1.76070085
137Clubbing of toes (HP:0100760)1.76001071
138Recurrent skin infections (HP:0001581)1.75694344
139Abnormal hair whorl (HP:0010721)1.75028926
140Bell-shaped thorax (HP:0001591)1.74884459
141Small hand (HP:0200055)1.74474493
142Acute myeloid leukemia (HP:0004808)1.73664842
143J-shaped sella turcica (HP:0002680)1.72517354
144Aplasia/Hypoplasia of the uvula (HP:0010293)1.72015660
145Dialeptic seizures (HP:0011146)1.71357948
146Impaired proprioception (HP:0010831)1.71240241
147Deformed sella turcica (HP:0002681)1.70463421
148Facial diplegia (HP:0001349)1.70346764
149Progressive inability to walk (HP:0002505)1.70298132
150Abnormality of macular pigmentation (HP:0008002)1.69614266
151Ketoacidosis (HP:0001993)1.68838569
152Congenital, generalized hypertrichosis (HP:0004540)1.68317578
153Hypoplasia of the pons (HP:0012110)1.67708310
154Retinitis pigmentosa (HP:0000510)1.67435966
155Short foot (HP:0001773)1.67228675
156Abnormal spermatogenesis (HP:0008669)1.66371215
157White forelock (HP:0002211)1.66290758
158Focal motor seizures (HP:0011153)1.65189926
159Pendular nystagmus (HP:0012043)1.65068034
160Leukocytosis (HP:0001974)1.64787138
161Hypoplasia of the thymus (HP:0000778)1.64193955
162Conjunctival telangiectasia (HP:0000524)1.63965125
163Drooling (HP:0002307)1.63433087
164Patchy hypopigmentation of hair (HP:0011365)1.61266496
165Optic neuritis (HP:0100653)1.61076989
166Retrobulbar optic neuritis (HP:0100654)1.61076989
167Stomatitis (HP:0010280)1.58188043
168Alveolar cell carcinoma (HP:0006519)1.58113057
169Poikiloderma (HP:0001029)1.56935670
170Amyotrophic lateral sclerosis (HP:0007354)1.54893403
171Neutropenia (HP:0001875)1.53866730
172Recurrent pneumonia (HP:0006532)1.52800421
173Abnormality of T cell physiology (HP:0011840)1.51231337
174Thyroiditis (HP:0100646)1.51150397
175Aplasia/Hypoplasia of the spleen (HP:0010451)1.51101441
176Hypoproteinemia (HP:0003075)1.49053946
177Cellulitis (HP:0100658)1.48767522
178Protruding tongue (HP:0010808)1.48116403
179Abnormality of the pons (HP:0007361)1.47552107
180Abnormality of midbrain morphology (HP:0002418)1.46718524

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.67552959
2MAP2K74.97397158
3MAP3K44.87761669
4PDK34.11145343
5PDK44.11145343
6STK163.83015214
7CDK33.06548902
8MAP4K22.99460420
9ACVR1B2.96382329
10NUAK12.63007515
11MUSK2.57865859
12ADRBK22.35127801
13WNK32.33394896
14TESK12.30577314
15PDK22.28483466
16MAP2K42.26511447
17MAP4K12.25715255
18RIPK42.10876060
19MAP3K142.02949595
20PNCK2.01506598
21ZAK2.01222710
22MAPK131.99274338
23CAMK1G1.96954094
24PIK3CG1.95887447
25KIT1.79353756
26GRK11.75246051
27NEK11.65616019
28CASK1.64282019
29PINK11.62283070
30TXK1.59081745
31CCNB11.58244495
32TRIM281.57751149
33INSRR1.52649056
34STK391.51179624
35IRAK41.50400713
36WNK41.50305888
37MAPK151.42756052
38MKNK21.42619081
39TNIK1.41872005
40CAMK1D1.41648680
41OXSR11.40780106
42TBK11.34581108
43AKT31.30118404
44MAP3K131.29546406
45EIF2AK31.24138034
46PLK21.21604451
47CAMKK21.15573911
48BTK1.15103703
49PTK2B1.14714397
50PAK31.11630565
51ICK1.10401394
52TAOK31.10381210
53IKBKE1.07980508
54ERBB31.07612839
55BRSK21.06460340
56PIK3CA1.05483698
57VRK11.04737400
58TEC1.04470873
59TYK21.00990955
60JAK30.99090243
61PRKD30.98677450
62TRPM70.97620365
63STK38L0.96901155
64NEK20.96245822
65ADRBK10.96000186
66TLK10.93505598
67TGFBR10.89580548
68NTRK30.89033741
69LATS10.88711055
70FGFR20.86812503
71IKBKB0.85262662
72FES0.80737087
73PIM20.80105478
74PLK40.77983866
75PLK30.76186259
76SYK0.75687569
77EIF2AK20.75218935
78MKNK10.74308115
79MST40.73904585
80PBK0.73362759
81FER0.72381731
82MYLK0.68734819
83LCK0.68398329
84ZAP700.68388394
85BCKDK0.68149137
86NLK0.66431487
87CDK190.65776984
88EPHA30.63911594
89WNK10.63698736
90BCR0.63605929
91PASK0.58700164
92MAPKAPK50.58530932
93CSF1R0.57540923
94BMPR20.57405412
95PRKCG0.56214910
96MAP2K60.55758564
97ARAF0.55023076
98RET0.54633151
99STK40.54404849
100SGK20.53491960
101CSNK1G20.52639377
102CLK10.52471805
103CSNK1G10.50803482
104BMPR1B0.49763701
105YES10.49677368
106LYN0.49529058
107OBSCN0.48778669
108MARK10.47656125
109NME20.47214335
110CDK80.46927283
111HCK0.46168070
112DAPK10.45917302
113ATR0.45288450
114PKN10.44816872
115WEE10.44810990
116PIM10.44193089
117STK30.44169715
118ITK0.43914293
119BLK0.43386164
120DYRK1B0.43317145
121PRKAA20.42511891
122PHKG10.41226151
123PHKG20.41226151
124CSK0.41184541
125IRAK10.40990267
126CSNK1D0.40723133
127CAMK2A0.40177351
128TIE10.39689558
129CDK40.39632619
130DYRK30.39226936
131CSNK1G30.38678791
132BRD40.38542764
133FLT30.38215141
134STK380.37202613
135ATM0.34624682
136PRKACA0.34505984
137MARK30.33540727
138PRKG10.33164556
139EPHA40.33032959
140IGF1R0.32855730
141RPS6KA40.32676525
142STK110.32644869
143NTRK20.32627034
144CSNK1A10.30450898
145CAMK10.30269699
146DYRK1A0.29721707
147CSNK1A1L0.29281324
148PRKACB0.29099909
149ERBB20.28864454
150PRKCE0.28126814
151RPS6KA50.27813411
152GRK70.27061468
153PRKD20.25600764
154MATK0.25450309
155PRKCQ0.25325009
156JAK10.25050055
157HIPK20.24913085
158IRAK30.24559398
159DAPK20.24407138
160PRKCD0.23994800
161JAK20.23864627
162SIK30.23300253
163RPS6KB20.21486415
164TNK20.20351336
165RPS6KB10.20111099
166BUB10.19796275
167MST1R0.19664598
168CHUK0.19043094

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.76869944
2Phototransduction_Homo sapiens_hsa047442.71275913
3Butanoate metabolism_Homo sapiens_hsa006502.56508736
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40491245
5Nitrogen metabolism_Homo sapiens_hsa009102.37689994
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.30472025
7Allograft rejection_Homo sapiens_hsa053302.12224149
8Tryptophan metabolism_Homo sapiens_hsa003802.06671311
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.05614083
10Nicotine addiction_Homo sapiens_hsa050332.04332460
11Measles_Homo sapiens_hsa051622.02208061
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97881712
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94919704
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.84409613
15Antigen processing and presentation_Homo sapiens_hsa046121.82485602
16Fanconi anemia pathway_Homo sapiens_hsa034601.82270921
17Primary immunodeficiency_Homo sapiens_hsa053401.79515453
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78535314
19Herpes simplex infection_Homo sapiens_hsa051681.76119356
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.74494683
21Selenocompound metabolism_Homo sapiens_hsa004501.72975274
22Pertussis_Homo sapiens_hsa051331.72927688
23Dorso-ventral axis formation_Homo sapiens_hsa043201.71203642
24Osteoclast differentiation_Homo sapiens_hsa043801.69969628
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68173524
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.66635810
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.65360164
28Autoimmune thyroid disease_Homo sapiens_hsa053201.65200731
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.64284315
30Graft-versus-host disease_Homo sapiens_hsa053321.64200925
31B cell receptor signaling pathway_Homo sapiens_hsa046621.62547313
32Influenza A_Homo sapiens_hsa051641.59887436
33Rheumatoid arthritis_Homo sapiens_hsa053231.55035828
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.53397119
35Basal transcription factors_Homo sapiens_hsa030221.52713209
36Type I diabetes mellitus_Homo sapiens_hsa049401.47844755
37Non-homologous end-joining_Homo sapiens_hsa034501.44108150
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40372594
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39151960
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.38511275
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35795229
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33298895
43Olfactory transduction_Homo sapiens_hsa047401.32578313
44Homologous recombination_Homo sapiens_hsa034401.31550762
45ABC transporters_Homo sapiens_hsa020101.24967753
46Renin secretion_Homo sapiens_hsa049241.22510742
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22399456
48Tuberculosis_Homo sapiens_hsa051521.20974748
49Leishmaniasis_Homo sapiens_hsa051401.20366933
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18842156
51RNA degradation_Homo sapiens_hsa030181.18363678
52Chemical carcinogenesis_Homo sapiens_hsa052041.17121738
53Hematopoietic cell lineage_Homo sapiens_hsa046401.15594578
54Legionellosis_Homo sapiens_hsa051341.14710162
55T cell receptor signaling pathway_Homo sapiens_hsa046601.14215814
56Hepatitis B_Homo sapiens_hsa051611.13734996
57Shigellosis_Homo sapiens_hsa051311.13595187
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13243376
59Pentose phosphate pathway_Homo sapiens_hsa000301.10895047
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10254572
61Salmonella infection_Homo sapiens_hsa051321.09132268
62Retinol metabolism_Homo sapiens_hsa008301.08730407
63Huntingtons disease_Homo sapiens_hsa050161.08128115
64Ribosome_Homo sapiens_hsa030101.07901938
65RNA polymerase_Homo sapiens_hsa030201.07239238
66DNA replication_Homo sapiens_hsa030301.04464454
67Asthma_Homo sapiens_hsa053101.02531485
68Morphine addiction_Homo sapiens_hsa050321.01564830
69Serotonergic synapse_Homo sapiens_hsa047261.00307645
70Salivary secretion_Homo sapiens_hsa049701.00150327
71Circadian entrainment_Homo sapiens_hsa047130.99975125
72Peroxisome_Homo sapiens_hsa041460.99279879
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.98711810
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97644568
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97554413
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97544955
77One carbon pool by folate_Homo sapiens_hsa006700.96650034
78Arachidonic acid metabolism_Homo sapiens_hsa005900.96047563
79Vitamin B6 metabolism_Homo sapiens_hsa007500.95830263
80Protein export_Homo sapiens_hsa030600.95386762
81Histidine metabolism_Homo sapiens_hsa003400.94987255
82Malaria_Homo sapiens_hsa051440.93934191
83beta-Alanine metabolism_Homo sapiens_hsa004100.91806892
84Regulation of autophagy_Homo sapiens_hsa041400.91243219
85Proteasome_Homo sapiens_hsa030500.91008252
86Other glycan degradation_Homo sapiens_hsa005110.90775935
87GABAergic synapse_Homo sapiens_hsa047270.88524235
88Pyruvate metabolism_Homo sapiens_hsa006200.88475445
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87683718
90Ether lipid metabolism_Homo sapiens_hsa005650.85618267
91Mismatch repair_Homo sapiens_hsa034300.85198624
92Sphingolipid metabolism_Homo sapiens_hsa006000.85163268
93TNF signaling pathway_Homo sapiens_hsa046680.85060874
94Circadian rhythm_Homo sapiens_hsa047100.84397300
95Purine metabolism_Homo sapiens_hsa002300.81951577
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81484788
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80438434
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79551724
99Toxoplasmosis_Homo sapiens_hsa051450.79212895
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.78311418
101Ovarian steroidogenesis_Homo sapiens_hsa049130.78309008
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77433330
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77239403
104Type II diabetes mellitus_Homo sapiens_hsa049300.76809244
105Apoptosis_Homo sapiens_hsa042100.76767040
106Phagosome_Homo sapiens_hsa041450.74690563
107Staphylococcus aureus infection_Homo sapiens_hsa051500.74473284
108Propanoate metabolism_Homo sapiens_hsa006400.73008154
109Alzheimers disease_Homo sapiens_hsa050100.72533848
110Viral myocarditis_Homo sapiens_hsa054160.71659647
111Calcium signaling pathway_Homo sapiens_hsa040200.70444026
112African trypanosomiasis_Homo sapiens_hsa051430.69888263
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69429702
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69269772
115Folate biosynthesis_Homo sapiens_hsa007900.68543210
116Epstein-Barr virus infection_Homo sapiens_hsa051690.67875354
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66631795
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.65863359
119Lysosome_Homo sapiens_hsa041420.65625316
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65595752
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.64957174
122Lysine degradation_Homo sapiens_hsa003100.63697290
123Glycerolipid metabolism_Homo sapiens_hsa005610.62385242
124Linoleic acid metabolism_Homo sapiens_hsa005910.61644724
125Hepatitis C_Homo sapiens_hsa051600.61560748
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61176409
127Fatty acid degradation_Homo sapiens_hsa000710.60505043
128Insulin secretion_Homo sapiens_hsa049110.59073938
129cAMP signaling pathway_Homo sapiens_hsa040240.58771261
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.57864353
131Caffeine metabolism_Homo sapiens_hsa002320.57685191
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.56896950
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56785326
134Glutamatergic synapse_Homo sapiens_hsa047240.56421293
135Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56034325
136Dopaminergic synapse_Homo sapiens_hsa047280.55650739
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53644684
138Collecting duct acid secretion_Homo sapiens_hsa049660.53256890
139Long-term depression_Homo sapiens_hsa047300.53035162
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52400855
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.52162433
142Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52103130
143Acute myeloid leukemia_Homo sapiens_hsa052210.51036074
144Systemic lupus erythematosus_Homo sapiens_hsa053220.51018847
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50093859
146Chemokine signaling pathway_Homo sapiens_hsa040620.49757255
147Taste transduction_Homo sapiens_hsa047420.49154202
148PPAR signaling pathway_Homo sapiens_hsa033200.48942247
149Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48891813
150Amphetamine addiction_Homo sapiens_hsa050310.47810585
151Oxidative phosphorylation_Homo sapiens_hsa001900.46923288
152Metabolic pathways_Homo sapiens_hsa011000.41776590
153Cholinergic synapse_Homo sapiens_hsa047250.38896912
154Nucleotide excision repair_Homo sapiens_hsa034200.38412542
155Fatty acid metabolism_Homo sapiens_hsa012120.36930416
156Fat digestion and absorption_Homo sapiens_hsa049750.35093241
157Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34734717
158Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31185679
159Oxytocin signaling pathway_Homo sapiens_hsa049210.29153419
160Mineral absorption_Homo sapiens_hsa049780.27834747
161Cocaine addiction_Homo sapiens_hsa050300.26544536

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