POU6F1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.05584948
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.79987650
3vocalization behavior (GO:0071625)5.73231315
4locomotory exploration behavior (GO:0035641)5.73085981
5synaptic vesicle maturation (GO:0016188)5.39939098
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.35926276
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.01064056
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.97183267
9regulation of glutamate receptor signaling pathway (GO:1900449)4.93275804
10glutamate secretion (GO:0014047)4.86423098
11regulation of synaptic vesicle exocytosis (GO:2000300)4.83205603
12synaptic vesicle exocytosis (GO:0016079)4.72447929
13neuron cell-cell adhesion (GO:0007158)4.70772566
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.67855519
15protein localization to synapse (GO:0035418)4.58310111
16regulation of synaptic vesicle transport (GO:1902803)4.29845525
17dendritic spine morphogenesis (GO:0060997)4.28564851
18regulation of synapse structural plasticity (GO:0051823)4.27044805
19regulation of neuronal synaptic plasticity (GO:0048168)4.26966991
20exploration behavior (GO:0035640)4.24177909
21layer formation in cerebral cortex (GO:0021819)4.16142504
22neurotransmitter secretion (GO:0007269)4.15446959
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.11197272
24synaptic transmission, glutamatergic (GO:0035249)4.10673957
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.06046273
26positive regulation of synapse maturation (GO:0090129)4.03869094
27neurotransmitter-gated ion channel clustering (GO:0072578)4.00994955
28cerebellar granule cell differentiation (GO:0021707)3.99726510
29glutamate receptor signaling pathway (GO:0007215)3.94616425
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.78548087
31positive regulation of membrane potential (GO:0045838)3.74415983
32neuron-neuron synaptic transmission (GO:0007270)3.72180219
33axon ensheathment in central nervous system (GO:0032291)3.70649831
34central nervous system myelination (GO:0022010)3.70649831
35synaptic vesicle endocytosis (GO:0048488)3.69682132
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.68484142
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.63830730
38neuronal action potential propagation (GO:0019227)3.59486489
39long-term memory (GO:0007616)3.58301210
40regulation of dendritic spine morphogenesis (GO:0061001)3.57811042
41gamma-aminobutyric acid transport (GO:0015812)3.56482747
42cerebellar Purkinje cell differentiation (GO:0021702)3.52298251
43neuron recognition (GO:0008038)3.52276826
44prepulse inhibition (GO:0060134)3.52269984
45proline transport (GO:0015824)3.51181178
46cellular potassium ion homeostasis (GO:0030007)3.50934783
47positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.49384724
48axonal fasciculation (GO:0007413)3.48203125
49regulation of postsynaptic membrane potential (GO:0060078)3.48160855
50postsynaptic membrane organization (GO:0001941)3.45383460
51potassium ion import (GO:0010107)3.43953011
52cell migration in hindbrain (GO:0021535)3.42556030
53dendrite morphogenesis (GO:0048813)3.35764366
54regulation of synaptic plasticity (GO:0048167)3.35693838
55sodium ion export (GO:0071436)3.31039612
56neuromuscular process controlling balance (GO:0050885)3.30025152
57positive regulation of synaptic transmission, GABAergic (GO:0032230)3.29311645
58amino acid import (GO:0043090)3.28174147
59regulation of voltage-gated calcium channel activity (GO:1901385)3.27182469
60neurotransmitter transport (GO:0006836)3.26791544
61regulation of neurotransmitter secretion (GO:0046928)3.24391138
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.23517166
63G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.22657104
64activation of protein kinase A activity (GO:0034199)3.20648779
65negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18642639
66central nervous system projection neuron axonogenesis (GO:0021952)3.18288890
67regulation of synapse maturation (GO:0090128)3.17786693
68positive regulation of dendritic spine morphogenesis (GO:0061003)3.13686756
69membrane depolarization during action potential (GO:0086010)3.12563599
70cell communication by electrical coupling (GO:0010644)3.12048929
71startle response (GO:0001964)3.11710221
72long-term synaptic potentiation (GO:0060291)3.10712089
73auditory behavior (GO:0031223)3.10409535
74neuromuscular synaptic transmission (GO:0007274)3.08663404
75presynaptic membrane assembly (GO:0097105)3.06858197
76regulation of ARF protein signal transduction (GO:0032012)3.06043376
77regulation of neurotransmitter levels (GO:0001505)3.05885064
78calcium ion-dependent exocytosis (GO:0017156)3.05411426
79neurotransmitter uptake (GO:0001504)3.04163888
80presynaptic membrane organization (GO:0097090)3.03651115
81membrane depolarization (GO:0051899)3.03627276
82detection of calcium ion (GO:0005513)3.03443360
83membrane hyperpolarization (GO:0060081)3.02779782
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02580166
85synaptic transmission (GO:0007268)3.01532162
86regulation of dendritic spine development (GO:0060998)2.99549797
87mechanosensory behavior (GO:0007638)2.98545338
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97864805
89potassium ion homeostasis (GO:0055075)2.96190973
90neuromuscular process controlling posture (GO:0050884)2.95374597
91dendritic spine organization (GO:0097061)2.95330156
92innervation (GO:0060384)2.94971610
93regulation of neurotransmitter transport (GO:0051588)2.94190578
94positive regulation of neurotransmitter secretion (GO:0001956)2.93240753
95neuronal ion channel clustering (GO:0045161)2.92543057
96glycosphingolipid biosynthetic process (GO:0006688)2.91946011
97response to auditory stimulus (GO:0010996)2.91825480
98positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.91706323
99acidic amino acid transport (GO:0015800)2.88797617
100learning (GO:0007612)2.86756111
101regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.86483234
102establishment of mitochondrion localization (GO:0051654)2.84750600
103regulation of vesicle fusion (GO:0031338)2.84073904
104transmission of nerve impulse (GO:0019226)2.83929350
105positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.83670396
106glycine transport (GO:0015816)2.83343084
107synapse assembly (GO:0007416)2.83332207
108positive regulation of neurotransmitter transport (GO:0051590)2.83030289
109L-amino acid import (GO:0043092)2.81677689
110negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.81364190
111intraspecies interaction between organisms (GO:0051703)2.79174900
112social behavior (GO:0035176)2.79174900
113cellular potassium ion transport (GO:0071804)2.78939544
114potassium ion transmembrane transport (GO:0071805)2.78939544
115G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.78493479
116positive regulation of dendritic spine development (GO:0060999)2.78063217
117positive regulation of synaptic transmission (GO:0050806)2.77440044
118synaptic vesicle transport (GO:0048489)2.77387985
119establishment of synaptic vesicle localization (GO:0097480)2.77387985
120regulation of synaptic transmission (GO:0050804)2.75145681
121nerve growth factor signaling pathway (GO:0038180)2.74752308
122gamma-aminobutyric acid signaling pathway (GO:0007214)2.74746273
123glial cell proliferation (GO:0014009)2.73099762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.78733465
2GBX2_23144817_ChIP-Seq_PC3_Human2.71500117
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66094169
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65597629
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.65078284
6REST_21632747_ChIP-Seq_MESCs_Mouse2.64186013
7DROSHA_22980978_ChIP-Seq_HELA_Human2.59418630
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52864454
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39393719
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39393719
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.36318329
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33329916
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30013812
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29189157
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17364013
16* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15153977
17* EZH2_27294783_Chip-Seq_ESCs_Mouse2.14451204
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14063529
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.13987538
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.13551197
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.10199963
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09841195
23* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07617213
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90406413
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83609684
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81863032
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80362838
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.78048110
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73186823
30AR_21572438_ChIP-Seq_LNCaP_Human1.72906305
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71039449
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64209688
33* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63628976
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.58648330
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49630348
36SMAD4_21799915_ChIP-Seq_A2780_Human1.49126319
37* KDM2B_26808549_Chip-Seq_K562_Human1.40919931
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39500338
39* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37550245
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.36018125
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29206222
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27265239
43SOX2_21211035_ChIP-Seq_LN229_Gbm1.23126471
44WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22813400
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22366384
46* AR_19668381_ChIP-Seq_PC3_Human1.22190328
47EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21585755
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21150295
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19241434
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.19066597
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18656114
52* RING1B_27294783_Chip-Seq_NPCs_Mouse1.14126824
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13347722
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.12627158
55ZNF274_21170338_ChIP-Seq_K562_Hela1.12293324
56P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12079665
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11584184
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11419848
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11419848
60ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10586960
61AHR_22903824_ChIP-Seq_MCF-7_Human1.09696133
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09408347
63AR_25329375_ChIP-Seq_VCAP_Human1.09259348
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.09030102
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.08131231
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08076785
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08066210
68MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07918323
69STAT3_23295773_ChIP-Seq_U87_Human1.07247786
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06284420
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05478161
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03946678
73TCF4_23295773_ChIP-Seq_U87_Human1.03643289
74ELK4_26923725_Chip-Seq_MESODERM_Mouse1.02455630
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00915388
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98539482
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98212137
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98132763
79IGF1R_20145208_ChIP-Seq_DFB_Human0.98030477
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97767891
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96915984
82P300_19829295_ChIP-Seq_ESCs_Human0.96572485
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95748647
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94808611
85KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94240147
86SMAD3_21741376_ChIP-Seq_ESCs_Human0.93526776
87YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93312371
88TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92967224
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92814968
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92767092
91SMAD4_21741376_ChIP-Seq_HESCs_Human0.91880634
92FLI1_21867929_ChIP-Seq_TH2_Mouse0.91516357
93TAF15_26573619_Chip-Seq_HEK293_Human0.91236378
94CTCF_27219007_Chip-Seq_Bcells_Human0.90507066
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90260985
96TP53_16413492_ChIP-PET_HCT116_Human0.90102137
97TET1_21490601_ChIP-Seq_MESCs_Mouse0.89998029
98RNF2_27304074_Chip-Seq_NSC_Mouse0.89326127
99RUNX2_22187159_ChIP-Seq_PCA_Human0.89320754
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88488577
101PRDM14_20953172_ChIP-Seq_ESCs_Human0.88373138
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87952713
103RXR_22108803_ChIP-Seq_LS180_Human0.87747652
104KLF4_19829295_ChIP-Seq_ESCs_Human0.87269365
105SMAD3_21741376_ChIP-Seq_HESCs_Human0.87042420
106STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86382251
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86153547
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85792046
109WDR5_24793694_ChIP-Seq_LNCAP_Human0.85472021
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85122639
111* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84867250
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84576525
113KDM2B_26808549_Chip-Seq_REH_Human0.84189380
114OCT4_19829295_ChIP-Seq_ESCs_Human0.83807144
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.83731206
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82772900
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82742578
118TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82742379
119VDR_22108803_ChIP-Seq_LS180_Human0.82404026
120LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81709185
121BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81546213

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.91138888
2MP0003880_abnormal_central_pattern4.50688132
3MP0003635_abnormal_synaptic_transmissio4.19148202
4MP0004270_analgesia3.62925420
5MP0002063_abnormal_learning/memory/cond3.36565162
6MP0009745_abnormal_behavioral_response3.25775011
7MP0005423_abnormal_somatic_nervous3.10316926
8MP0002064_seizures3.03146760
9MP0009046_muscle_twitch2.95750564
10MP0002822_catalepsy2.91985068
11MP0002572_abnormal_emotion/affect_behav2.69864149
12MP0001968_abnormal_touch/_nociception2.67205383
13MP0001486_abnormal_startle_reflex2.54172296
14MP0002734_abnormal_mechanical_nocicepti2.34555253
15MP0002272_abnormal_nervous_system2.27637467
16MP0009780_abnormal_chondrocyte_physiolo2.22308069
17MP0000778_abnormal_nervous_system2.19999023
18MP0004858_abnormal_nervous_system2.05578557
19MP0002736_abnormal_nociception_after2.02948562
20MP0001501_abnormal_sleep_pattern2.01795935
21MP0008569_lethality_at_weaning2.01474572
22MP0004811_abnormal_neuron_physiology1.95191717
23MP0003787_abnormal_imprinting1.90622405
24MP0002184_abnormal_innervation1.88201679
25MP0002735_abnormal_chemical_nociception1.85476763
26MP0002557_abnormal_social/conspecific_i1.81835636
27MP0001984_abnormal_olfaction1.80574189
28MP0002067_abnormal_sensory_capabilities1.79360385
29MP0001440_abnormal_grooming_behavior1.78383282
30MP0000569_abnormal_digit_pigmentation1.73943435
31MP0001986_abnormal_taste_sensitivity1.71378138
32MP0002733_abnormal_thermal_nociception1.69554807
33MP0004885_abnormal_endolymph1.68156504
34MP0001970_abnormal_pain_threshold1.67440663
35MP0002909_abnormal_adrenal_gland1.65397521
36MP0005646_abnormal_pituitary_gland1.63588605
37MP0003329_amyloid_beta_deposits1.60159824
38MP0000955_abnormal_spinal_cord1.58474101
39MP0003879_abnormal_hair_cell1.53234289
40MP0004924_abnormal_behavior1.50304621
41MP0005386_behavior/neurological_phenoty1.50304621
42MP0008961_abnormal_basal_metabolism1.49354350
43MP0002882_abnormal_neuron_morphology1.45221905
44MP0001502_abnormal_circadian_rhythm1.39955167
45MP0002066_abnormal_motor_capabilities/c1.34884610
46MP0005409_darkened_coat_color1.28031541
47MP0005410_abnormal_fertilization1.27218837
48MP0002152_abnormal_brain_morphology1.25983287
49MP0003633_abnormal_nervous_system1.25707672
50MP0002653_abnormal_ependyma_morphology1.23323651
51MP0006276_abnormal_autonomic_nervous1.22622119
52MP0004043_abnormal_pH_regulation1.11424312
53MP0003631_nervous_system_phenotype1.07020475
54MP0005551_abnormal_eye_electrophysiolog1.06973691
55MP0006292_abnormal_olfactory_placode1.06048163
56MP0004130_abnormal_muscle_cell1.04497830
57MP0000751_myopathy1.03428399
58MP0005394_taste/olfaction_phenotype1.03220267
59MP0005499_abnormal_olfactory_system1.03220267
60MP0001177_atelectasis1.02843484
61MP0001485_abnormal_pinna_reflex0.98848152
62MP0004142_abnormal_muscle_tone0.98723317
63MP0002069_abnormal_eating/drinking_beha0.94455058
64MP0005645_abnormal_hypothalamus_physiol0.91218714
65MP0001188_hyperpigmentation0.90190699
66MP0002638_abnormal_pupillary_reflex0.89280735
67MP0002837_dystrophic_cardiac_calcinosis0.86095477
68MP0004742_abnormal_vestibular_system0.85182640
69MP0000631_abnormal_neuroendocrine_gland0.84273223
70MP0004085_abnormal_heartbeat0.84136951
71MP0005623_abnormal_meninges_morphology0.81810063
72MP0002234_abnormal_pharynx_morphology0.81716510
73MP0002229_neurodegeneration0.79836412
74MP0003861_abnormal_nervous_system0.79029614
75MP0004147_increased_porphyrin_level0.78765935
76MP0003698_abnormal_male_reproductive0.78695407
77MP0003632_abnormal_nervous_system0.77744133
78MP0005535_abnormal_body_temperature0.77428688
79MP0003137_abnormal_impulse_conducting0.77209746
80MP0003045_fibrosis0.75524919
81MP0008874_decreased_physiological_sensi0.75267812
82MP0003075_altered_response_to0.74919483
83MP0003646_muscle_fatigue0.74841268
84MP0002752_abnormal_somatic_nervous0.74048420
85MP0008872_abnormal_physiological_respon0.72469028
86MP0003634_abnormal_glial_cell0.72453482
87MP0000026_abnormal_inner_ear0.72370074
88MP0005670_abnormal_white_adipose0.71204053
89MP0005253_abnormal_eye_physiology0.68029109
90MP0004233_abnormal_muscle_weight0.66110189
91MP0004145_abnormal_muscle_electrophysio0.65104939
92MP0003690_abnormal_glial_cell0.64661801
93MP0002090_abnormal_vision0.64490539
94MP0001529_abnormal_vocalization0.64012918
95MP0001963_abnormal_hearing_physiology0.63970649
96MP0003283_abnormal_digestive_organ0.62050737
97MP0003122_maternal_imprinting0.61614647
98MP0010769_abnormal_survival0.61008108
99MP0001943_abnormal_respiration0.60108896
100MP0001905_abnormal_dopamine_level0.59665785
101MP0005174_abnormal_tail_pigmentation0.59633042
102MP0010768_mortality/aging0.57503482
103MP0000015_abnormal_ear_pigmentation0.57452446
104MP0002082_postnatal_lethality0.57015038
105MP0010770_preweaning_lethality0.57015038
106MP0003121_genomic_imprinting0.57000812
107MP0000920_abnormal_myelination0.55860940
108MP0001299_abnormal_eye_distance/0.55762483
109MP0000604_amyloidosis0.55493873
110MP0002876_abnormal_thyroid_physiology0.55347308
111MP0008877_abnormal_DNA_methylation0.54536038
112MP0004215_abnormal_myocardial_fiber0.51360863
113MP0005167_abnormal_blood-brain_barrier0.50418196
114MP0001348_abnormal_lacrimal_gland0.49961533
115MP0004484_altered_response_of0.49352556

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.95077758
2Myokymia (HP:0002411)5.49436350
3Focal seizures (HP:0007359)4.74753126
4Visual hallucinations (HP:0002367)4.29144261
5Epileptic encephalopathy (HP:0200134)4.26105777
6Progressive cerebellar ataxia (HP:0002073)4.17645081
7Febrile seizures (HP:0002373)4.10562208
8Hyperacusis (HP:0010780)3.50510475
9Atonic seizures (HP:0010819)3.45578027
10Elfin facies (HP:0004428)3.41000360
11Poor eye contact (HP:0000817)3.36899260
12Limb dystonia (HP:0002451)3.34859312
13Abnormality of the lower motor neuron (HP:0002366)3.34134970
14Insomnia (HP:0100785)3.33563173
15Broad-based gait (HP:0002136)3.33107446
16Bundle branch block (HP:0011710)3.30805550
17Action tremor (HP:0002345)3.27506163
18Abnormal social behavior (HP:0012433)3.25226492
19Impaired social interactions (HP:0000735)3.25226492
20Ankle clonus (HP:0011448)3.24890004
21Hyperventilation (HP:0002883)3.22338494
22Gaze-evoked nystagmus (HP:0000640)3.14926064
23Impaired vibration sensation in the lower limbs (HP:0002166)3.11556087
24Absence seizures (HP:0002121)3.04413198
25Truncal ataxia (HP:0002078)3.01839887
26Obstructive sleep apnea (HP:0002870)2.98452446
27Urinary bladder sphincter dysfunction (HP:0002839)2.95378648
28Supranuclear gaze palsy (HP:0000605)2.95195427
29Overriding aorta (HP:0002623)2.87245559
30Genetic anticipation (HP:0003743)2.82412062
31Renovascular hypertension (HP:0100817)2.78929836
32Urinary urgency (HP:0000012)2.77382287
33Dialeptic seizures (HP:0011146)2.74506146
34Generalized tonic-clonic seizures (HP:0002069)2.73228091
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.72789765
36Absent/shortened dynein arms (HP:0200106)2.72789765
37Impaired smooth pursuit (HP:0007772)2.70314201
38Abnormality of ocular smooth pursuit (HP:0000617)2.69100522
39Postural instability (HP:0002172)2.63991890
40Cerebral hypomyelination (HP:0006808)2.61260823
41Abnormal eating behavior (HP:0100738)2.59682214
42Depression (HP:0000716)2.59470788
43Pointed chin (HP:0000307)2.59126174
44Amblyopia (HP:0000646)2.56917164
45Stereotypic behavior (HP:0000733)2.55908601
46Delusions (HP:0000746)2.54253877
47Dysdiadochokinesis (HP:0002075)2.44044648
48Flat cornea (HP:0007720)2.43295644
49Dysmetria (HP:0001310)2.41837613
50Sleep apnea (HP:0010535)2.41646949
51Hemiparesis (HP:0001269)2.39014333
52Congenital stationary night blindness (HP:0007642)2.36925697
53Hemiplegia (HP:0002301)2.32467923
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.31112116
55Excessive salivation (HP:0003781)2.30268900
56Drooling (HP:0002307)2.30268900
57Intention tremor (HP:0002080)2.29558778
58Ventricular fibrillation (HP:0001663)2.26533709
59Neurofibrillary tangles (HP:0002185)2.23963974
60Type II lissencephaly (HP:0007260)2.22571563
61Spastic gait (HP:0002064)2.22398947
62Mutism (HP:0002300)2.21777400
63Akinesia (HP:0002304)2.21643090
64Lissencephaly (HP:0001339)2.20732065
65Dysmetric saccades (HP:0000641)2.20444967
66Progressive inability to walk (HP:0002505)2.19431119
67Renal duplication (HP:0000075)2.18785397
68Megalencephaly (HP:0001355)2.14353275
69Anxiety (HP:0000739)2.14304328
70Clonus (HP:0002169)2.14074362
71Lower limb muscle weakness (HP:0007340)2.07832594
72Tetraplegia (HP:0002445)2.04568766
73Torticollis (HP:0000473)2.04258714
74Impaired vibratory sensation (HP:0002495)2.04230996
75Abnormal EKG (HP:0003115)2.02032461
76Abnormal respiratory motile cilium physiology (HP:0012261)2.01481306
77Polydipsia (HP:0001959)2.01135533
78Abnormal drinking behavior (HP:0030082)2.01135533
79Absent speech (HP:0001344)2.00714121
80Lower limb amyotrophy (HP:0007210)2.00452772
81Craniofacial dystonia (HP:0012179)2.00186778
82Inability to walk (HP:0002540)1.99517383
83Spastic tetraparesis (HP:0001285)1.97991725
84Amyotrophic lateral sclerosis (HP:0007354)1.97882002
85Prolonged QT interval (HP:0001657)1.96858130
86Obsessive-compulsive behavior (HP:0000722)1.96476019
87Protruding tongue (HP:0010808)1.96056020
88Fetal akinesia sequence (HP:0001989)1.95815601
89Increased circulating renin level (HP:0000848)1.93702216
90Epileptiform EEG discharges (HP:0011182)1.93456353
91Rapidly progressive (HP:0003678)1.91580706
92Split foot (HP:0001839)1.91097371
93Nephronophthisis (HP:0000090)1.90057888
94Bradykinesia (HP:0002067)1.89565579
95Intellectual disability, severe (HP:0010864)1.89507219
96Papilledema (HP:0001085)1.88775152
97Diplopia (HP:0000651)1.87892929
98Abnormality of binocular vision (HP:0011514)1.87892929
99Annular pancreas (HP:0001734)1.87524806
100Open mouth (HP:0000194)1.86298384
101Buphthalmos (HP:0000557)1.86280425
102EEG with generalized epileptiform discharges (HP:0011198)1.86210439
103Status epilepticus (HP:0002133)1.85825544
104Gait imbalance (HP:0002141)1.84126834
105Focal dystonia (HP:0004373)1.83241327
106Gait ataxia (HP:0002066)1.82252533
107Bowel diverticulosis (HP:0005222)1.82194222
108Abnormality of the diencephalon (HP:0010662)1.81920862
109Peripheral hypomyelination (HP:0007182)1.81327940
110Heart block (HP:0012722)1.79523386
111Hypsarrhythmia (HP:0002521)1.79019703
112Abnormality of the corticospinal tract (HP:0002492)1.78704766
113Aplasia/Hypoplasia of the brainstem (HP:0007362)1.78331026
114Hypoplasia of the brainstem (HP:0002365)1.78331026
115Thickened helices (HP:0000391)1.78289136
116Polyphagia (HP:0002591)1.77645061
117Autism (HP:0000717)1.77404590
118Polygenic inheritance (HP:0010982)1.77388753
119Hypokalemic alkalosis (HP:0001949)1.77348138
120CNS hypomyelination (HP:0003429)1.76245361
121Pheochromocytoma (HP:0002666)1.75560986
122Widely spaced teeth (HP:0000687)1.74139336
123Progressive microcephaly (HP:0000253)1.74104632
124Intellectual disability, profound (HP:0002187)1.73864943
125Retinal dysplasia (HP:0007973)1.73797003
126Anosmia (HP:0000458)1.72876417
127Spastic tetraplegia (HP:0002510)1.71188303
128Morphological abnormality of the pyramidal tract (HP:0002062)1.69123804
129Abnormal respiratory motile cilium morphology (HP:0005938)1.68726106
130Abnormal respiratory epithelium morphology (HP:0012253)1.68726106
131Optic nerve hypoplasia (HP:0000609)1.67561982
132Rhinitis (HP:0012384)1.67027993
133Megalocornea (HP:0000485)1.67017323
134Hypoplasia of the corpus callosum (HP:0002079)1.65893603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.43962511
2MAP3K94.12136321
3NTRK33.82161988
4MARK13.44741962
5MAP3K42.81304082
6DAPK22.81071802
7PRKD32.79214517
8PAK62.47875502
9MAP2K72.25850892
10NTRK22.25343838
11MINK12.21664878
12CAMKK12.06131930
13SIK22.05595313
14STK381.88730503
15TYRO31.65056638
16RIPK41.61402675
17MAP2K41.54797484
18PRPF4B1.54080306
19KSR11.47648420
20PDK31.40101579
21PDK41.40101579
22CDK51.39091459
23TAOK11.35566389
24KSR21.34733745
25DAPK11.29955703
26MAP3K21.26827198
27SGK31.23382133
28PRKCH1.23329774
29SGK21.13988588
30SGK4941.11127903
31SGK2231.11127903
32NTRK11.10939894
33STK111.10909577
34FES1.09146277
35PRKCG1.08938032
36MAPK131.07546728
37CASK1.05073874
38PKN11.04521647
39PNCK1.02756141
40FRK1.00757043
41ALK0.97028020
42UHMK10.95453998
43PINK10.94499175
44PTK2B0.94496703
45MAP4K20.94293839
46CAMK1G0.92693253
47ICK0.92465417
48PHKG10.91723916
49PHKG20.91723916
50RET0.90558739
51CAMK10.89384161
52MARK20.88879368
53PLK20.88007409
54ADRBK20.82520504
55TNIK0.81941342
56DYRK1A0.80028825
57FGFR20.79133311
58RIPK10.77086814
59GRK50.76810684
60MAP2K60.76187688
61PDK10.73641175
62OXSR10.72790112
63CAMKK20.71444988
64SGK10.69777282
65TAOK30.69177283
66OBSCN0.67523485
67LMTK20.66996743
68TRIB30.66529983
69CAMK2A0.66359563
70PDK20.66345142
71MAP3K70.64163211
72MAP3K130.63875683
73NEK60.63770731
74CDK190.60457006
75CDK180.60058712
76CDK150.59989064
77CCNB10.59794086
78PAK30.59074364
79PRKD20.59028874
80CAMK40.58640313
81PRKCZ0.58187062
82MAPK100.57863494
83PDPK10.57578549
84LATS20.56761790
85PDGFRB0.56697350
86CAMK2G0.56200926
87WNK30.55794356
88CSNK1G20.55302522
89AKT30.53988450
90SIK30.52329373
91PIK3CG0.52190139
92BRSK10.51570438
93CDK11A0.51568442
94RPS6KA30.50949520
95TNK20.50390698
96MAP3K120.50362821
97MAPK70.49320498
98INSRR0.48967723
99CAMK2B0.48655356
100CDK30.48325473
101CDC42BPA0.48319960
102DMPK0.48058887
103CDK140.47855096
104GRK10.46772839
105DYRK1B0.46698381
106FYN0.46691731
107TXK0.45507005
108MAP3K100.45265287
109BRD40.44849231
110EPHA30.44735312
111MAPK80.44015290
112WNK10.43327974
113ROCK10.42705951
114MAPK120.42061355
115BMPR1B0.40765967
116PRKAA10.40498709
117MAPK150.39523088
118HCK0.39333862
119RPS6KA20.38528333
120PDGFRA0.36315562
121PRKG10.36164758
122PRKACA0.35962258
123CAMK2D0.35183795
124PRKCE0.34677630
125PRKCB0.32920811
126GSK3B0.30617227
127DDR20.29362121
128MAP3K10.28657109

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.16208296
2Synaptic vesicle cycle_Homo sapiens_hsa047212.75359516
3Olfactory transduction_Homo sapiens_hsa047402.63954802
4Circadian entrainment_Homo sapiens_hsa047132.46963697
5Glutamatergic synapse_Homo sapiens_hsa047242.41350012
6Long-term potentiation_Homo sapiens_hsa047202.36104921
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30663567
8GABAergic synapse_Homo sapiens_hsa047272.25606710
9Morphine addiction_Homo sapiens_hsa050322.23539085
10Amphetamine addiction_Homo sapiens_hsa050312.22706667
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96367446
12Dopaminergic synapse_Homo sapiens_hsa047281.89965760
13Salivary secretion_Homo sapiens_hsa049701.89728340
14Gastric acid secretion_Homo sapiens_hsa049711.85779499
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85679306
16Insulin secretion_Homo sapiens_hsa049111.82313197
17Cholinergic synapse_Homo sapiens_hsa047251.79883171
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68211934
19Oxytocin signaling pathway_Homo sapiens_hsa049211.66768527
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65633952
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60391458
22Renin secretion_Homo sapiens_hsa049241.58338026
23Taste transduction_Homo sapiens_hsa047421.55349063
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.46400911
25Cocaine addiction_Homo sapiens_hsa050301.45981970
26Calcium signaling pathway_Homo sapiens_hsa040201.45303064
27Type II diabetes mellitus_Homo sapiens_hsa049301.43307722
28GnRH signaling pathway_Homo sapiens_hsa049121.37858653
29Long-term depression_Homo sapiens_hsa047301.35284741
30Glioma_Homo sapiens_hsa052141.30605874
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30069859
32ErbB signaling pathway_Homo sapiens_hsa040121.29983749
33Serotonergic synapse_Homo sapiens_hsa047261.27864697
34Gap junction_Homo sapiens_hsa045401.25521981
35cAMP signaling pathway_Homo sapiens_hsa040241.24501978
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24357241
37Axon guidance_Homo sapiens_hsa043601.22032882
38Estrogen signaling pathway_Homo sapiens_hsa049151.20353017
39Dorso-ventral axis formation_Homo sapiens_hsa043201.18291533
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12645920
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08326263
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01506224
43VEGF signaling pathway_Homo sapiens_hsa043700.98158758
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97241417
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.97099288
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96731481
47Regulation of autophagy_Homo sapiens_hsa041400.94882573
48Melanogenesis_Homo sapiens_hsa049160.94328136
49Endometrial cancer_Homo sapiens_hsa052130.93792165
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92778259
51Nitrogen metabolism_Homo sapiens_hsa009100.92575540
52Choline metabolism in cancer_Homo sapiens_hsa052310.91086687
53Phototransduction_Homo sapiens_hsa047440.89543152
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.86922598
55MAPK signaling pathway_Homo sapiens_hsa040100.84999070
56Collecting duct acid secretion_Homo sapiens_hsa049660.81158354
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80829708
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.80176144
59mTOR signaling pathway_Homo sapiens_hsa041500.79928553
60Inositol phosphate metabolism_Homo sapiens_hsa005620.79557908
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77688099
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77285493
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76951351
64Non-small cell lung cancer_Homo sapiens_hsa052230.76225164
65Dilated cardiomyopathy_Homo sapiens_hsa054140.75634371
66Glucagon signaling pathway_Homo sapiens_hsa049220.75385707
67Circadian rhythm_Homo sapiens_hsa047100.74250284
68Renal cell carcinoma_Homo sapiens_hsa052110.71293189
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71122871
70Oocyte meiosis_Homo sapiens_hsa041140.71016909
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69403140
72Rap1 signaling pathway_Homo sapiens_hsa040150.69324408
73Pancreatic secretion_Homo sapiens_hsa049720.67659089
74T cell receptor signaling pathway_Homo sapiens_hsa046600.66606931
75Ether lipid metabolism_Homo sapiens_hsa005650.65367272
76Insulin signaling pathway_Homo sapiens_hsa049100.64206905
77Thyroid hormone synthesis_Homo sapiens_hsa049180.63154471
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61880164
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61575700
80Wnt signaling pathway_Homo sapiens_hsa043100.61454507
81Ras signaling pathway_Homo sapiens_hsa040140.60203464
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59287899
83Colorectal cancer_Homo sapiens_hsa052100.57927458
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56897931
85Endocytosis_Homo sapiens_hsa041440.55403490
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54462029
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54313987
88Butanoate metabolism_Homo sapiens_hsa006500.53327018
89Linoleic acid metabolism_Homo sapiens_hsa005910.53015442
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52653870
91Cardiac muscle contraction_Homo sapiens_hsa042600.52166132
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52164945
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.50837473
94Ovarian steroidogenesis_Homo sapiens_hsa049130.50067821
95Vitamin B6 metabolism_Homo sapiens_hsa007500.49824177
96B cell receptor signaling pathway_Homo sapiens_hsa046620.49612406
97Chemokine signaling pathway_Homo sapiens_hsa040620.49609630
98Prolactin signaling pathway_Homo sapiens_hsa049170.49515896
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46689549
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44661431
101ABC transporters_Homo sapiens_hsa020100.43058977
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41371521
103Bile secretion_Homo sapiens_hsa049760.40078067
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39121847
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.38925737
106Chronic myeloid leukemia_Homo sapiens_hsa052200.37687155
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35514016
108Histidine metabolism_Homo sapiens_hsa003400.34355514
109AMPK signaling pathway_Homo sapiens_hsa041520.33074494
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.32879695
111FoxO signaling pathway_Homo sapiens_hsa040680.32726294
112Arginine and proline metabolism_Homo sapiens_hsa003300.32715698
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32382929
114beta-Alanine metabolism_Homo sapiens_hsa004100.27664032
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27249328
116Glycerolipid metabolism_Homo sapiens_hsa005610.26983860
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23790192
118Hedgehog signaling pathway_Homo sapiens_hsa043400.22824100

Most similar genes based on co-expression Upload to Enrichr

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