PP2D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tachykinin receptor signaling pathway (GO:0007217)7.26757741
2axon ensheathment in central nervous system (GO:0032291)7.10572826
3central nervous system myelination (GO:0022010)7.10572826
4presynaptic membrane assembly (GO:0097105)5.70484056
5Notch signaling involved in heart development (GO:0061314)5.07848051
6presynaptic membrane organization (GO:0097090)5.07439441
7blood vessel maturation (GO:0001955)4.92568989
8endothelium development (GO:0003158)4.82849996
9fatty acid elongation (GO:0030497)4.50852246
10regulation of germinal center formation (GO:0002634)4.37896813
11establishment of protein localization to Golgi (GO:0072600)4.36994669
12negative regulation of smooth muscle cell differentiation (GO:0051151)4.25328852
13protein targeting to Golgi (GO:0000042)4.22474143
14single strand break repair (GO:0000012)4.15151711
15lymphangiogenesis (GO:0001946)4.07304046
16positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.02333196
17retrograde transport, vesicle recycling within Golgi (GO:0000301)3.99649027
18long-chain fatty acid biosynthetic process (GO:0042759)3.97361772
19histone H3-K4 trimethylation (GO:0080182)3.96208610
20nuclear pore complex assembly (GO:0051292)3.92825548
21regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.92130985
22limb bud formation (GO:0060174)3.87958900
23protein K11-linked deubiquitination (GO:0035871)3.85257714
24epithelial cilium movement (GO:0003351)3.80306330
25short-term memory (GO:0007614)3.79293223
26neuron cell-cell adhesion (GO:0007158)3.78757502
27postsynaptic membrane organization (GO:0001941)3.74931214
28negative regulation of execution phase of apoptosis (GO:1900118)3.69424608
29regulation of interferon-beta biosynthetic process (GO:0045357)3.69112356
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.65454401
31negative regulation of neurotransmitter transport (GO:0051589)3.64669777
32myelination (GO:0042552)3.64465163
33ensheathment of neurons (GO:0007272)3.60742744
34axon ensheathment (GO:0008366)3.60742744
35protein prenylation (GO:0018342)3.54160444
36prenylation (GO:0097354)3.54160444
37regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.51875797
38ribosomal small subunit biogenesis (GO:0042274)3.50000545
39transcytosis (GO:0045056)3.41031876
40negative regulation of neurotransmitter secretion (GO:0046929)3.40694335
41positive regulation of digestive system process (GO:0060456)3.37404106
42microglial cell activation (GO:0001774)3.33863916
43negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.33721207
44negative regulation of T-helper cell differentiation (GO:0045623)3.33721207
45photoreceptor cell differentiation (GO:0046530)3.31647957
46eye photoreceptor cell differentiation (GO:0001754)3.31647957
47positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.26401642
48cilium movement (GO:0003341)3.25897382
49neuronal action potential propagation (GO:0019227)3.25606094
50detection of molecule of bacterial origin (GO:0032490)3.23661749
51cellular response to ethanol (GO:0071361)3.23048218
52GTP biosynthetic process (GO:0006183)3.20270071
53regulation of interleukin-8 biosynthetic process (GO:0045414)3.19566049
54RNA destabilization (GO:0050779)3.18536742
55endothelial tube morphogenesis (GO:0061154)3.18405704
56morphogenesis of an endothelium (GO:0003159)3.18405704
57heart trabecula morphogenesis (GO:0061384)3.16052694
58positive regulation of synapse assembly (GO:0051965)3.15464014
59cerebral cortex radially oriented cell migration (GO:0021799)3.15187802
60nuclear pore organization (GO:0006999)3.14928979
61protein neddylation (GO:0045116)3.12745471
62mRNA transcription (GO:0009299)3.12437462
63regulation of collateral sprouting (GO:0048670)3.11396913
64spermatid nucleus differentiation (GO:0007289)3.11024760
65ventricular trabecula myocardium morphogenesis (GO:0003222)3.10737149
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.10197460
67oligodendrocyte differentiation (GO:0048709)3.09919314
68modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.09430982
69positive regulation by organism of defense response of other organism involved in symbiotic interact3.09430982
70modulation by symbiont of host immune response (GO:0052553)3.09430982
71positive regulation by symbiont of host defense response (GO:0052509)3.09430982
72modulation by symbiont of host defense response (GO:0052031)3.09430982
73modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.09430982
74pore complex assembly (GO:0046931)3.07725125
75glucosamine-containing compound catabolic process (GO:1901072)3.06494190
76neural tube formation (GO:0001841)3.05213433
77sulfation (GO:0051923)3.02946085
78magnesium ion transport (GO:0015693)3.02047304
79cell wall macromolecule catabolic process (GO:0016998)3.01865146
80histone mRNA catabolic process (GO:0071044)2.99352002
81negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.98530720
82clathrin coat assembly (GO:0048268)2.98355816
83cochlea development (GO:0090102)2.95626952
84mRNA transcription from RNA polymerase II promoter (GO:0042789)2.95123300
85negative regulation of translation, ncRNA-mediated (GO:0040033)2.95114078
86regulation of translation, ncRNA-mediated (GO:0045974)2.95114078
87negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.95114078
88regulation of pigment cell differentiation (GO:0050932)2.94123677
89acrosome reaction (GO:0007340)2.91030804
90sphingoid metabolic process (GO:0046519)2.89162766
91nuclear envelope reassembly (GO:0031468)2.88535977
92mitotic nuclear envelope reassembly (GO:0007084)2.88535977
93positive regulation of cellular amine metabolic process (GO:0033240)2.88077900
94viral transcription (GO:0019083)2.88028855
95L-ascorbic acid metabolic process (GO:0019852)2.86971376
96lateral sprouting from an epithelium (GO:0060601)2.85797806
97cotranslational protein targeting to membrane (GO:0006613)2.85555284
98positive regulation of toll-like receptor signaling pathway (GO:0034123)2.84959056
99negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.83665177
100dopamine biosynthetic process (GO:0042416)2.82323732
101cardiac left ventricle morphogenesis (GO:0003214)2.81593709
102heart valve formation (GO:0003188)2.81159403
103protein localization to Golgi apparatus (GO:0034067)2.80756816
104ventricular system development (GO:0021591)2.80413637
105protein targeting to ER (GO:0045047)2.79412249
106energy coupled proton transport, down electrochemical gradient (GO:0015985)2.78199470
107ATP synthesis coupled proton transport (GO:0015986)2.78199470
108membrane assembly (GO:0071709)2.77154845
109respiratory electron transport chain (GO:0022904)2.76755445
110translational termination (GO:0006415)2.76154660
111neuron remodeling (GO:0016322)2.75759306
112regulation of gamma-delta T cell activation (GO:0046643)2.75735937
113monoubiquitinated protein deubiquitination (GO:0035520)2.75382852
114sperm motility (GO:0030317)2.74886980
115response to methylmercury (GO:0051597)2.74803682
116positive regulation of gamma-delta T cell activation (GO:0046645)2.74582871
117cellular response to glucose starvation (GO:0042149)2.74528978
118establishment of protein localization to endoplasmic reticulum (GO:0072599)2.74079038
119otic vesicle formation (GO:0030916)2.73794113
120negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.72744138
121mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.72108212
122negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.72074504
123negative regulation of interleukin-1 beta production (GO:0032691)2.70887808
124substantia nigra development (GO:0021762)2.70218351
125electron transport chain (GO:0022900)2.69507339
126epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69442045
127macrophage activation involved in immune response (GO:0002281)2.68677338
128SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.68649758
129macrophage activation (GO:0042116)2.67951557
130acrosome assembly (GO:0001675)2.67689805
131negative regulation of glycoprotein biosynthetic process (GO:0010561)2.67681479
132cilium or flagellum-dependent cell motility (GO:0001539)2.67327907
133axonemal dynein complex assembly (GO:0070286)2.66744400
134protein localization to endoplasmic reticulum (GO:0070972)2.66435439
135positive regulation of triglyceride lipase activity (GO:0061365)2.63772339
136positive regulation of lipoprotein lipase activity (GO:0051006)2.63772339
137fusion of sperm to egg plasma membrane (GO:0007342)2.63619214
138multicellular organism reproduction (GO:0032504)2.63612021
139nonmotile primary cilium assembly (GO:0035058)2.62102174
140trabecula morphogenesis (GO:0061383)2.61649236
141histone H2A ubiquitination (GO:0033522)2.59690618
142response to histamine (GO:0034776)2.59685941
143cellular extravasation (GO:0045123)2.58850416
144positive regulation of meiotic cell cycle (GO:0051446)2.58268931
145regulation of protein kinase C signaling (GO:0090036)2.57811789
146response to redox state (GO:0051775)2.57165480
147lymph vessel development (GO:0001945)2.57006080
148regulation of catecholamine metabolic process (GO:0042069)2.56790062
149regulation of dopamine metabolic process (GO:0042053)2.56790062
150positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.55711282
151regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.55711282
152diol metabolic process (GO:0034311)2.55345663
153intra-Golgi vesicle-mediated transport (GO:0006891)2.55260316
154negative regulation of synaptic transmission, GABAergic (GO:0032229)2.54270287
155keratinocyte development (GO:0003334)2.53868677
156megakaryocyte development (GO:0035855)2.53374030
157organ growth (GO:0035265)2.52147541
158negative regulation of B cell proliferation (GO:0030889)2.51610345
159NAD biosynthetic process (GO:0009435)2.51367551
160GPI anchor biosynthetic process (GO:0006506)2.51083112
161negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.50972014
162negative regulation of Rho protein signal transduction (GO:0035024)2.50719186
163positive regulation of oligodendrocyte differentiation (GO:0048714)2.49841709
164peptidyl-lysine trimethylation (GO:0018023)2.49325277
165cAMP catabolic process (GO:0006198)2.48125804
166definitive hemopoiesis (GO:0060216)2.46396073
167activated T cell proliferation (GO:0050798)2.46240311
168import into cell (GO:0098657)2.46209052
169transmission of nerve impulse (GO:0019226)2.45872807
170neuronal ion channel clustering (GO:0045161)2.43694658
171amino acid import (GO:0043090)2.43145626
172phosphatidylserine acyl-chain remodeling (GO:0036150)2.42865365
173negative regulation of protein localization to cell surface (GO:2000009)2.42730187
174positive regulation of meiosis (GO:0045836)2.42612439
175negative regulation of NF-kappaB import into nucleus (GO:0042347)2.42404022
176endothelial cell differentiation (GO:0045446)2.41561860
177regulation of interleukin-12 biosynthetic process (GO:0045075)2.41165319
178negative regulation of adaptive immune response (GO:0002820)2.40709966
179protein K63-linked deubiquitination (GO:0070536)2.40408542
180protein localization to cilium (GO:0061512)2.40273588
181atrial cardiac muscle cell action potential (GO:0086014)2.40002720
182cellular response to arsenic-containing substance (GO:0071243)2.39641776
183negative regulation of inclusion body assembly (GO:0090084)2.38898258
184UTP biosynthetic process (GO:0006228)2.38282272
185developmental pigmentation (GO:0048066)2.37433916
186protein heterotetramerization (GO:0051290)2.37403880
187regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.36639674
188signal peptide processing (GO:0006465)2.34355199
189glycerophospholipid catabolic process (GO:0046475)2.34174898
190gamma-aminobutyric acid signaling pathway (GO:0007214)2.33424309
191nucleotide transmembrane transport (GO:1901679)2.33131278
192termination of RNA polymerase III transcription (GO:0006386)2.32453172
193transcription elongation from RNA polymerase III promoter (GO:0006385)2.32453172
194positive regulation of cell fate commitment (GO:0010455)2.31953583

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.66779402
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.62757248
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.34553660
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.13767800
5TAF15_26573619_Chip-Seq_HEK293_Human3.02852037
6GBX2_23144817_ChIP-Seq_PC3_Human3.02819601
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.91781626
8VDR_22108803_ChIP-Seq_LS180_Human2.91135810
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.61769169
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57261588
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.49518041
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44241470
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.43191400
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34847283
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30756448
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.30708273
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.22988602
18RUNX_20019798_ChIP-Seq_JUKART_Human2.21407556
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.21261878
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09005743
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.04756040
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.03606462
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.03551750
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.02219888
25ER_23166858_ChIP-Seq_MCF-7_Human2.01981917
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01589169
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00473481
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99411820
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.97724453
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.97724453
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.97724453
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.92638617
33VDR_24787735_ChIP-Seq_THP-1_Human1.90807250
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88276372
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88232458
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.87451198
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86954053
38FUS_26573619_Chip-Seq_HEK293_Human1.86799803
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84961494
40CBP_20019798_ChIP-Seq_JUKART_Human1.83959291
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.83959291
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81173036
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.80982967
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79375800
45P300_19829295_ChIP-Seq_ESCs_Human1.78185256
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73904407
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70236766
48IGF1R_20145208_ChIP-Seq_DFB_Human1.67951050
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66622722
50RNF2_27304074_Chip-Seq_NSC_Mouse1.65347797
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.63100712
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.61331527
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61073309
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.59843368
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.59202893
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58606514
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58606514
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58028520
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57298546
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57245012
61AR_21572438_ChIP-Seq_LNCaP_Human1.56977975
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56364214
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55825761
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54449646
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.53833495
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53214278
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53030627
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51887669
69P53_22387025_ChIP-Seq_ESCs_Mouse1.50884268
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.50000389
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48738296
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47355580
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47220950
74CMYC_18555785_Chip-Seq_ESCs_Mouse1.46281440
75P300_18555785_Chip-Seq_ESCs_Mouse1.46017362
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.45971980
77STAT3_23295773_ChIP-Seq_U87_Human1.45662553
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45429876
79TCF4_22108803_ChIP-Seq_LS180_Human1.45195989
80SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44539305
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44428292
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44428292
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44145976
84EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.42627987
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42525915
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.42244805
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.41834100
88MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41612850
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.38286875
90FOXM1_26456572_ChIP-Seq_MCF-7_Human1.37509748
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36933690
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36699851
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.35351387
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.34017155
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33078713
96IRF8_27001747_Chip-Seq_BMDM_Mouse1.31546594
97RNF2_27304074_Chip-Seq_ESCs_Mouse1.31339376
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.30159526
99WT1_19549856_ChIP-ChIP_CCG9911_Human1.29479520
100STAT3_18555785_Chip-Seq_ESCs_Mouse1.29359023
101TAL1_26923725_Chip-Seq_HPCs_Mouse1.29051314
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28361521
103CDX2_22108803_ChIP-Seq_LS180_Human1.27322034
104NMYC_18555785_Chip-Seq_ESCs_Mouse1.27297910
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25068790
106RUNX1_27457419_Chip-Seq_LIVER_Mouse1.24898546
107BCAT_22108803_ChIP-Seq_LS180_Human1.24576584
108TCF4_23295773_ChIP-Seq_U87_Human1.23048891
109SOX2_18555785_Chip-Seq_ESCs_Mouse1.23044513
110TP53_18474530_ChIP-ChIP_U2OS_Human1.22905073
111MYB_26560356_Chip-Seq_TH2_Human1.22894124
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21848393
113RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21408780
114SMAD4_21799915_ChIP-Seq_A2780_Human1.20249522
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19391955
116KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19177969
117JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17713940
118AHR_22903824_ChIP-Seq_MCF-7_Human1.17646434
119NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17266427
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17266427
121KLF4_18555785_Chip-Seq_ESCs_Mouse1.17083883
122SMAD1_18555785_Chip-Seq_ESCs_Mouse1.16045255
123EWS_26573619_Chip-Seq_HEK293_Human1.15873965
124CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15165938
125OCT4_18555785_Chip-Seq_ESCs_Mouse1.15120246
126SMRT_27268052_Chip-Seq_Bcells_Human1.14807862
127RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14571584
128AR_25329375_ChIP-Seq_VCAP_Human1.14269046
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13930537
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13895820
131TRIM28_21343339_ChIP-Seq_HEK293_Human1.12846974
132PRDM14_20953172_ChIP-Seq_ESCs_Human1.12526847
133CRX_20693478_ChIP-Seq_RETINA_Mouse1.12203889
134TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11456747
135POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10995301
136KDM2B_26808549_Chip-Seq_REH_Human1.10939763
137GATA3_26560356_Chip-Seq_TH2_Human1.10900895
138BP1_19119308_ChIP-ChIP_Hs578T_Human1.10866053
139OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09371300
140IRF8_22096565_ChIP-ChIP_GC-B_Human1.07958555
141STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07639255
142ZFX_18555785_Chip-Seq_ESCs_Mouse1.07629871
143PU1_27457419_Chip-Seq_LIVER_Mouse1.07376764
144IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06315810
145RXR_22108803_ChIP-Seq_LS180_Human1.06037195
146MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04831749
147GATA3_27048872_Chip-Seq_THYMUS_Human1.03670550
148GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03375144
149CTCF_18555785_Chip-Seq_ESCs_Mouse1.02184840
150CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02104753
151IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02102911
152RUNX2_22187159_ChIP-Seq_PCA_Human1.02086932
153KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01576566
154ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01281088
155ZNF274_21170338_ChIP-Seq_K562_Hela1.00397064
156EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99873515
157CJUN_26792858_Chip-Seq_BT549_Human0.99704167
158GATA1_19941826_ChIP-Seq_K562_Human0.99516084

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.06501673
2MP0003880_abnormal_central_pattern4.87227343
3MP0003136_yellow_coat_color4.32967246
4MP0004381_abnormal_hair_follicle3.58713065
5MP0002138_abnormal_hepatobiliary_system3.36186094
6MP0001879_abnormal_lymphatic_vessel3.31450324
7MP0008057_abnormal_DNA_replication3.25282262
8MP0008260_abnormal_autophagy2.95576977
9MP0000569_abnormal_digit_pigmentation2.82184160
10MP0002102_abnormal_ear_morphology2.78953390
11MP0001188_hyperpigmentation2.76984777
12MP0000920_abnormal_myelination2.67446392
13MP0005410_abnormal_fertilization2.66980773
14MP0010368_abnormal_lymphatic_system2.65952446
15MP0006054_spinal_hemorrhage2.60320531
16MP0005409_darkened_coat_color2.54319833
17MP0008877_abnormal_DNA_methylation2.53320136
18MP0004742_abnormal_vestibular_system2.53035941
19MP0000465_gastrointestinal_hemorrhage2.31955392
20MP0003724_increased_susceptibility_to2.22371551
21MP0006276_abnormal_autonomic_nervous2.15792463
22MP0004484_altered_response_of2.11526254
23MP0008004_abnormal_stomach_pH2.09689438
24MP0001905_abnormal_dopamine_level2.07861533
25MP0000566_synostosis2.00923871
26MP0003787_abnormal_imprinting1.92951255
27MP0001529_abnormal_vocalization1.91532270
28MP0000516_abnormal_urinary_system1.90043506
29MP0005367_renal/urinary_system_phenotyp1.90043506
30MP0004142_abnormal_muscle_tone1.87974984
31MP0002332_abnormal_exercise_endurance1.80988917
32MP0005671_abnormal_response_to1.78955495
33MP0001486_abnormal_startle_reflex1.78486111
34MP0005171_absent_coat_pigmentation1.77429045
35MP0002272_abnormal_nervous_system1.69676591
36MP0000778_abnormal_nervous_system1.69081230
37MP0001346_abnormal_lacrimal_gland1.66391281
38MP0001800_abnormal_humoral_immune1.61985035
39MP0003950_abnormal_plasma_membrane1.60039553
40MP0002796_impaired_skin_barrier1.53993045
41MP0000015_abnormal_ear_pigmentation1.51782835
42MP0001485_abnormal_pinna_reflex1.48002409
43MP0001835_abnormal_antigen_presentation1.47783802
44MP0002064_seizures1.46967273
45MP0003938_abnormal_ear_development1.44745440
46MP0005379_endocrine/exocrine_gland_phen1.43483930
47MP0009745_abnormal_behavioral_response1.43235440
48MP0000013_abnormal_adipose_tissue1.42427912
49MP0009046_muscle_twitch1.42141047
50MP0008961_abnormal_basal_metabolism1.40939320
51MP0005423_abnormal_somatic_nervous1.40924285
52MP0000372_irregular_coat_pigmentation1.40737740
53MP0002723_abnormal_immune_serum1.40182284
54MP0002938_white_spotting1.40147719
55MP0001440_abnormal_grooming_behavior1.39526239
56MP0003763_abnormal_thymus_physiology1.39381995
57MP0002572_abnormal_emotion/affect_behav1.38902605
58MP0004270_analgesia1.37770240
59MP0004883_abnormal_blood_vessel1.36995427
60MP0009250_abnormal_appendicular_skeleto1.36408665
61MP0003656_abnormal_erythrocyte_physiolo1.35900334
62MP0002166_altered_tumor_susceptibility1.33764216
63MP0005551_abnormal_eye_electrophysiolog1.32456061
64MP0005647_abnormal_sex_gland1.32302013
65MP0002419_abnormal_innate_immunity1.31984079
66MP0001968_abnormal_touch/_nociception1.29702132
67MP0002452_abnormal_antigen_presenting1.29487224
68MP0001853_heart_inflammation1.28592449
69MP0002277_abnormal_respiratory_mucosa1.28378866
70MP0000383_abnormal_hair_follicle1.28077894
71MP0002653_abnormal_ependyma_morphology1.27967787
72MP0002009_preneoplasia1.26700899
73MP0005310_abnormal_salivary_gland1.25414322
74MP0002163_abnormal_gland_morphology1.25215280
75MP0002067_abnormal_sensory_capabilities1.23953107
76MP0000647_abnormal_sebaceous_gland1.23151338
77MP0002398_abnormal_bone_marrow1.22261559
78MP0001986_abnormal_taste_sensitivity1.21785651
79MP0004233_abnormal_muscle_weight1.21478280
80MP0003941_abnormal_skin_development1.20904350
81MP0002734_abnormal_mechanical_nocicepti1.19332278
82MP0002420_abnormal_adaptive_immunity1.18988744
83MP0003635_abnormal_synaptic_transmissio1.17890333
84MP0002405_respiratory_system_inflammati1.15703185
85MP0001819_abnormal_immune_cell1.15354616
86MP0003300_gastrointestinal_ulcer1.15135609
87MP0005174_abnormal_tail_pigmentation1.13202119
88MP0004510_myositis1.12624691
89MP0005645_abnormal_hypothalamus_physiol1.12594839
90MP0003221_abnormal_cardiomyocyte_apopto1.12507538
91MP0003191_abnormal_cellular_cholesterol1.12002965
92MP0009764_decreased_sensitivity_to1.11622004
93MP0000026_abnormal_inner_ear1.11120023
94MP0005167_abnormal_blood-brain_barrier1.11091994
95MP0002638_abnormal_pupillary_reflex1.10138231
96MP0000767_abnormal_smooth_muscle1.08407077
97MP0003436_decreased_susceptibility_to1.08295638
98MP0000762_abnormal_tongue_morphology1.06898031
99MP0001545_abnormal_hematopoietic_system1.06774123
100MP0005397_hematopoietic_system_phenotyp1.06774123
101MP0006072_abnormal_retinal_apoptosis1.05662308
102MP0005075_abnormal_melanosome_morpholog1.05559698
103MP0000689_abnormal_spleen_morphology1.05050739
104MP0001501_abnormal_sleep_pattern1.04635829
105MP0006292_abnormal_olfactory_placode1.04356538
106MP0010352_gastrointestinal_tract_polyps1.03818486
107MP0002132_abnormal_respiratory_system1.02332416
108MP0000371_diluted_coat_color1.01996788
109MP0000716_abnormal_immune_system1.01782491
110MP0001970_abnormal_pain_threshold1.01207415
111MP0000249_abnormal_blood_vessel0.99937326
112MP0002063_abnormal_learning/memory/cond0.99913878
113MP0005000_abnormal_immune_tolerance0.99046479
114MP0009785_altered_susceptibility_to0.98268144
115MP0001963_abnormal_hearing_physiology0.97284372
116MP0001299_abnormal_eye_distance/0.97177144
117MP0003690_abnormal_glial_cell0.95731430
118MP0005248_abnormal_Harderian_gland0.95072046
119MP0009115_abnormal_fat_cell0.94888360
120MP0001340_abnormal_eyelid_morphology0.94530701
121MP0003937_abnormal_limbs/digits/tail_de0.94118329
122MP0002127_abnormal_cardiovascular_syste0.93964446
123MP0008058_abnormal_DNA_repair0.93588252
124MP0005501_abnormal_skin_physiology0.93354957
125MP0002229_neurodegeneration0.92987555
126MP0003634_abnormal_glial_cell0.91578282
127MP0001929_abnormal_gametogenesis0.90891609
128MP0010678_abnormal_skin_adnexa0.90819796
129MP0002722_abnormal_immune_system0.90443558
130MP0003943_abnormal_hepatobiliary_system0.89977568
131MP0004043_abnormal_pH_regulation0.89508209
132MP0001542_abnormal_bone_strength0.88585693
133MP0002177_abnormal_outer_ear0.88508717
134MP0000631_abnormal_neuroendocrine_gland0.88443399
135MP0002736_abnormal_nociception_after0.88382617
136MP0002752_abnormal_somatic_nervous0.87980932
137MP0005164_abnormal_response_to0.87716729
138MP0002882_abnormal_neuron_morphology0.87363735
139MP0002733_abnormal_thermal_nociception0.86844359
140MP0003698_abnormal_male_reproductive0.86546118
141MP0002557_abnormal_social/conspecific_i0.84887120
142MP0003303_peritoneal_inflammation0.84818712
143MP0003195_calcinosis0.84623075
144MP0002282_abnormal_trachea_morphology0.82856322
145MP0004185_abnormal_adipocyte_glucose0.81918330
146MP0005266_abnormal_metabolism0.81813225
147MP0010386_abnormal_urinary_bladder0.81398891
148MP0002168_other_aberrant_phenotype0.80970983
149MP0000703_abnormal_thymus_morphology0.80758773
150MP0003646_muscle_fatigue0.80736708
151MP0000613_abnormal_salivary_gland0.80703003
152MP0002735_abnormal_chemical_nociception0.79847879
153MP0004145_abnormal_muscle_electrophysio0.79795008
154MP0002429_abnormal_blood_cell0.79148104
155MP0000579_abnormal_nail_morphology0.79140767
156MP0004885_abnormal_endolymph0.77932092
157MP0002909_abnormal_adrenal_gland0.77681274
158MP0002184_abnormal_innervation0.77027186
159MP0005623_abnormal_meninges_morphology0.76401754
160MP0002095_abnormal_skin_pigmentation0.75829764
161MP0003011_delayed_dark_adaptation0.74821732
162MP0003045_fibrosis0.74745225
163MP0003091_abnormal_cell_migration0.74448674
164MP0003828_pulmonary_edema0.74072572
165MP0000049_abnormal_middle_ear0.73961353
166MP0002066_abnormal_motor_capabilities/c0.73813108
167MP0004147_increased_porphyrin_level0.73720177
168MP0001348_abnormal_lacrimal_gland0.73092690
169MP0002928_abnormal_bile_duct0.72934098
170MP0010771_integument_phenotype0.72907804
171MP0005253_abnormal_eye_physiology0.71662251
172MP0000462_abnormal_digestive_system0.71614741
173MP0002148_abnormal_hypersensitivity_rea0.71565017
174MP0001851_eye_inflammation0.71104655
175MP0000377_abnormal_hair_follicle0.71019999
176MP0005025_abnormal_response_to0.69840429
177MP0001502_abnormal_circadian_rhythm0.69451962
178MP0004947_skin_inflammation0.68993989
179MP0002006_tumorigenesis0.66432160
180MP0001533_abnormal_skeleton_physiology0.66362861
181MP0009765_abnormal_xenobiotic_induced0.62576233
182MP0002877_abnormal_melanocyte_morpholog0.62201201
183MP0005448_abnormal_energy_balance0.61252983
184MP0009703_decreased_birth_body0.60822348

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.86429675
2Parakeratosis (HP:0001036)4.71023794
3Abnormality of macular pigmentation (HP:0008002)4.52915402
4Dynein arm defect of respiratory motile cilia (HP:0012255)3.89195045
5Absent/shortened dynein arms (HP:0200106)3.89195045
6Congenital ichthyosiform erythroderma (HP:0007431)3.83251649
7Attenuation of retinal blood vessels (HP:0007843)3.71924454
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.63437723
9Concave nail (HP:0001598)3.51705270
10Decreased central vision (HP:0007663)3.42786730
11Colitis (HP:0002583)3.38305699
12Spontaneous hematomas (HP:0007420)3.34033901
13Renal Fanconi syndrome (HP:0001994)3.19377682
14Neurofibrillary tangles (HP:0002185)3.19222128
15Adactyly (HP:0009776)3.14263500
16Dyschromatopsia (HP:0007641)3.08982456
17Abnormal respiratory epithelium morphology (HP:0012253)3.08046223
18Abnormal respiratory motile cilium morphology (HP:0005938)3.08046223
19Abnormal ciliary motility (HP:0012262)3.06928333
20Abnormal respiratory motile cilium physiology (HP:0012261)3.01995274
21Acute necrotizing encephalopathy (HP:0006965)2.98167017
22Dyskinesia (HP:0100660)2.96860569
23Sensory axonal neuropathy (HP:0003390)2.96212337
24Curly hair (HP:0002212)2.95810616
25Hematochezia (HP:0002573)2.91115975
263-Methylglutaconic aciduria (HP:0003535)2.82820205
27Optic neuritis (HP:0100653)2.82085396
28Retrobulbar optic neuritis (HP:0100654)2.82085396
29Progressive macrocephaly (HP:0004481)2.80287018
30Congenital sensorineural hearing impairment (HP:0008527)2.79115671
31Conical tooth (HP:0000698)2.75703837
32Abnormal pupillary function (HP:0007686)2.74866939
33Episodic fever (HP:0001954)2.72534327
34Macular degeneration (HP:0000608)2.72007919
35Erythroderma (HP:0001019)2.71336135
36Choroideremia (HP:0001139)2.69620646
37Mitochondrial inheritance (HP:0001427)2.69516818
38Increased hepatocellular lipid droplets (HP:0006565)2.69196201
39Fragile nails (HP:0001808)2.67864448
40Peripheral hypomyelination (HP:0007182)2.62947966
41Abnormality of secondary sexual hair (HP:0009888)2.62153348
42Abnormality of the axillary hair (HP:0100134)2.62153348
43Abnormality of binocular vision (HP:0011514)2.60966602
44Diplopia (HP:0000651)2.60966602
45Esophageal varix (HP:0002040)2.58219324
46Split foot (HP:0001839)2.54872438
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.54188020
48Broad alveolar ridges (HP:0000187)2.53080445
49Portal hypertension (HP:0001409)2.52863862
50Recurrent bacterial skin infections (HP:0005406)2.52474325
51Hypophosphatemic rickets (HP:0004912)2.50777130
52Abnormality of renal resorption (HP:0011038)2.50145716
53Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.45519952
54Degeneration of the lateral corticospinal tracts (HP:0002314)2.45519952
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43670612
56Aplasia of the phalanges of the hand (HP:0009802)2.39021484
57Aplasia involving bones of the extremities (HP:0009825)2.39021484
58Aplasia involving bones of the upper limbs (HP:0009823)2.39021484
59Papillary thyroid carcinoma (HP:0002895)2.36905266
60Inflammation of the large intestine (HP:0002037)2.36573273
61Recurrent abscess formation (HP:0002722)2.36009280
62Abnormal hair whorl (HP:0010721)2.35909089
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35348784
64Neoplasm of the tracheobronchial system (HP:0100552)2.34556368
65Optic disc pallor (HP:0000543)2.32342183
66Alveolar cell carcinoma (HP:0006519)2.32094893
67Macrocytic anemia (HP:0001972)2.31137801
68Cupped ear (HP:0000378)2.31114448
69Retinal dysplasia (HP:0007973)2.30196986
70Acute encephalopathy (HP:0006846)2.29878005
71Stomach cancer (HP:0012126)2.29326864
72Abnormal mitochondria in muscle tissue (HP:0008316)2.28442895
73Alacrima (HP:0000522)2.27223610
74Prostate neoplasm (HP:0100787)2.23781662
75Conjunctival telangiectasia (HP:0000524)2.23209704
76Abnormality of the vasculature of the conjunctiva (HP:0008054)2.22854570
77Abnormality of the hepatic vasculature (HP:0006707)2.21472425
78Rhinitis (HP:0012384)2.21455358
79Medial flaring of the eyebrow (HP:0010747)2.21263479
80Bony spicule pigmentary retinopathy (HP:0007737)2.20927673
81Poikiloderma (HP:0001029)2.19776149
82Abnormality of the septum pellucidum (HP:0007375)2.19751186
83Chronic hepatic failure (HP:0100626)2.19038523
84Hyperkalemia (HP:0002153)2.17847201
85Absent eyebrow (HP:0002223)2.13519196
86Orchitis (HP:0100796)2.12891541
87Spastic paraplegia (HP:0001258)2.10088920
88Recurrent pneumonia (HP:0006532)2.09554809
89Abdominal situs inversus (HP:0003363)2.09488227
90Abnormality of abdominal situs (HP:0011620)2.09488227
91Adrenal hypoplasia (HP:0000835)2.09210847
92Absent septum pellucidum (HP:0001331)2.08865792
93Widely spaced teeth (HP:0000687)2.08577828
94Synostosis involving the elbow (HP:0003938)2.07481061
95Humeroradial synostosis (HP:0003041)2.07481061
96Thickened helices (HP:0000391)2.07189746
97Lipid accumulation in hepatocytes (HP:0006561)2.07050813
98Septo-optic dysplasia (HP:0100842)2.06101287
99Brittle hair (HP:0002299)2.05689127
100Abnormal hemoglobin (HP:0011902)2.05570035
101Depressed nasal tip (HP:0000437)2.03792190
102Keratoconjunctivitis sicca (HP:0001097)2.03634617
103Nasolacrimal duct obstruction (HP:0000579)2.01810586
104Hepatocellular necrosis (HP:0001404)1.99897140
105Upper limb muscle weakness (HP:0003484)1.99666346
106Keratoconjunctivitis (HP:0001096)1.99227340
107Hypokalemic alkalosis (HP:0001949)1.98824533
108Birth length less than 3rd percentile (HP:0003561)1.98654479
109Thyroid carcinoma (HP:0002890)1.98348662
110Submucous cleft hard palate (HP:0000176)1.97617696
111Gastrointestinal inflammation (HP:0004386)1.96942777
112Abnormality of macrophages (HP:0004311)1.96878880
113Chorioretinal atrophy (HP:0000533)1.95919351
114Paraplegia (HP:0010550)1.95539692
115Hypothermia (HP:0002045)1.93797494
116Chin dimple (HP:0010751)1.93659693
117Vacuolated lymphocytes (HP:0001922)1.93423829
118Abnormality of dental color (HP:0011073)1.93388668
119Hemiparesis (HP:0001269)1.92771383
120Anhidrosis (HP:0000970)1.92693367
121Leukodystrophy (HP:0002415)1.91525956
122Progressive inability to walk (HP:0002505)1.91469019
123Cerebral inclusion bodies (HP:0100314)1.90269302
124Cone-rod dystrophy (HP:0000548)1.89740337
125Increased CSF lactate (HP:0002490)1.89045589
126Obstructive sleep apnea (HP:0002870)1.89044732
127Vertebral arch anomaly (HP:0008438)1.88345203
128Abnormality of the aortic arch (HP:0012303)1.88116047
129Decreased subcutaneous fat (HP:0001002)1.86846025
130Abnormality of molar morphology (HP:0011070)1.86396940
131Abnormality of molar (HP:0011077)1.86396940
132Abolished electroretinogram (ERG) (HP:0000550)1.82892718
133Stomatitis (HP:0010280)1.82652583
134Tented upper lip vermilion (HP:0010804)1.82435704
135Decreased lacrimation (HP:0000633)1.82366214
136Slow saccadic eye movements (HP:0000514)1.82163793
137Morphological abnormality of the pyramidal tract (HP:0002062)1.80677076
138Abnormal biliary tract morphology (HP:0012440)1.79846221
139Aplasia/Hypoplasia of the lens (HP:0008063)1.79825882
140Hypoplastic pelvis (HP:0008839)1.79778834
141Vaginal atresia (HP:0000148)1.79684913
142Sleep apnea (HP:0010535)1.79507626
143Biliary tract neoplasm (HP:0100574)1.78356326
144Arthropathy (HP:0003040)1.78071367
145Congenital malformation of the right heart (HP:0011723)1.77816278
146Double outlet right ventricle (HP:0001719)1.77816278
147Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77351081
148Recurrent sinusitis (HP:0011108)1.76301944
149Myositis (HP:0100614)1.76259527
150Tubulointerstitial nephritis (HP:0001970)1.75945569
151Striae distensae (HP:0001065)1.74921760
152Genital tract atresia (HP:0001827)1.74733307
153Myelomeningocele (HP:0002475)1.73948511
154Premature rupture of membranes (HP:0001788)1.73782648
155Entropion (HP:0000621)1.73666491
156Abnormality of the phalanges of the 2nd finger (HP:0009541)1.72633853
157Subacute progressive viral hepatitis (HP:0006572)1.72325198
158Aplasia/hypoplasia of the uterus (HP:0008684)1.72055026
159Autoimmune hemolytic anemia (HP:0001890)1.71545182
160Keratitis (HP:0000491)1.71524208
161Fair hair (HP:0002286)1.70867059
162Focal motor seizures (HP:0011153)1.70848419
163Abnormal sex determination (HP:0012244)1.69879337
164Sex reversal (HP:0012245)1.69879337
165Patchy hypopigmentation of hair (HP:0011365)1.69046874
166Exertional dyspnea (HP:0002875)1.68943074
167Autoamputation (HP:0001218)1.68777293
168White forelock (HP:0002211)1.68452710
169Paralysis (HP:0003470)1.68359124
170Spontaneous abortion (HP:0005268)1.68242410
171Horizontal nystagmus (HP:0000666)1.68061442
172Microcytic anemia (HP:0001935)1.68021566
173Cerebral hemorrhage (HP:0001342)1.68002344
174Gait imbalance (HP:0002141)1.67694267
175Hypoparathyroidism (HP:0000829)1.67394710
176Progressive cerebellar ataxia (HP:0002073)1.67243275
177Basal cell carcinoma (HP:0002671)1.67170846
178Eczematoid dermatitis (HP:0000976)1.67111204
179Genetic anticipation (HP:0003743)1.66172804
180Scanning speech (HP:0002168)1.65985012
181Megalencephaly (HP:0001355)1.65934702
182Partial duplication of the phalanx of hand (HP:0009999)1.65079691
183Drooling (HP:0002307)1.64993916
184Cutis marmorata (HP:0000965)1.64801012
185Abnormality of the prostate (HP:0008775)1.64308589
186Hemoptysis (HP:0002105)1.63776103
187Thyroiditis (HP:0100646)1.63713069
188Excessive salivation (HP:0003781)1.63509451
189Aplasia/Hypoplasia of the earlobes (HP:0009906)1.63045211
190Hypoplasia of the iris (HP:0007676)1.61685512

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.83694421
2FRK4.28759059
3STK394.09927646
4EPHB23.17682893
5PLK43.05622944
6TLK12.90332690
7PBK2.89527676
8BRD42.71147065
9OXSR12.65424069
10IRAK22.62839401
11TNIK2.52947106
12PRKD32.33003098
13MST42.31797427
14TEC2.19598701
15FES2.18947471
16PNCK2.16617122
17IRAK12.15424257
18SIK32.03452957
19STK162.02323840
20WNK41.99783196
21BMPR1B1.98651044
22MKNK21.96791813
23CAMKK21.72879141
24IKBKE1.71513815
25BCR1.70735760
26MARK31.70056409
27MAPKAPK51.69721777
28PKN11.60630010
29MAPK151.54100184
30CDK121.53651606
31CDK191.52504247
32IRAK41.40129342
33EPHB11.38779568
34NME11.37353740
35TGFBR21.36963737
36MAP4K21.33050696
37BTK1.32190879
38NME21.29450005
39ITK1.28524140
40CAMK2B1.24164041
41FGR1.24162770
42BLK1.24159452
43TIE11.21399998
44FER1.20753916
45TAOK31.20346170
46MET1.18809423
47MAP3K41.16510145
48DYRK21.12349001
49MKNK11.12187503
50RIPK41.10241339
51MST1R1.10218384
52CAMK1D1.08785304
53EPHA41.08568243
54GRK71.08545266
55ICK1.07930416
56CLK11.07206300
57IKBKB1.07034539
58BMPR21.01537753
59UHMK11.01210913
60MATK1.01206483
61TAOK10.99525186
62CAMK1G0.98896672
63CAMK2D0.96680481
64MAP3K120.95635369
65CAMK2A0.94488956
66WEE10.94205346
67IRAK30.92740246
68STK240.92053315
69YES10.91793505
70ADRBK20.91192095
71ACVR1B0.91016218
72EIF2AK10.89969428
73JAK10.88992228
74LIMK10.88688086
75PAK30.87830880
76BRAF0.85490083
77NEK60.84702533
78MAP3K30.82682634
79CHUK0.82439866
80VRK10.82006414
81STK38L0.80985575
82PRKCE0.79581914
83WNK10.78696391
84MAP2K70.78673358
85EIF2AK30.77608968
86PRPF4B0.77301127
87CSNK1G30.76233033
88KIT0.76094413
89CSNK1G10.75932545
90MAPK70.75165075
91AKT30.72616921
92DYRK1A0.72293203
93PIK3CG0.71690866
94SGK20.70228256
95NLK0.69202242
96BRSK20.69151593
97PIK3CA0.68844343
98NTRK30.68212547
99BUB10.66059958
100TSSK60.64544518
101SRPK10.64173439
102PRKD20.63481342
103NUAK10.63413969
104CDK30.63095938
105CAMK40.63073048
106FGFR20.62959273
107STK110.62787431
108DYRK30.62648110
109RPS6KA50.61532398
110ERBB30.61416917
111TYK20.61287170
112DMPK0.59456739
113ABL20.59397747
114ROCK20.59342061
115PLK20.58947194
116MAPK130.58833234
117GRK60.57761915
118PRKCQ0.57306384
119CAMK2G0.56793740
120NTRK20.55632463
121SYK0.55588493
122CSK0.55305805
123MAP3K140.55168030
124STK380.54332489
125PINK10.53123199
126ADRBK10.52402598
127GRK50.51011749
128MUSK0.50349597
129CDK140.49217661
130STK30.48987955
131NTRK10.48417820
132CSNK1A1L0.47522150
133MAP2K30.47436770
134MAP4K10.46518774
135HCK0.46344600
136JAK20.46156310
137PDK20.43437082
138MINK10.43432128
139HIPK20.43399404
140SIK20.43195332
141TBK10.42917842
142MARK10.42705691
143LCK0.42575431
144TESK20.42571850
145GRK10.42195222
146TRPM70.41841607
147PRKG10.41749939
148CDK50.40753030
149MAP3K10.40717872
150CDK90.39638928
151CSNK1G20.39160200
152MAP2K20.39008390
153INSRR0.38575699
154LATS10.38237140
155EIF2AK20.37414184
156EPHA30.37279196
157TXK0.34901981
158PRKACA0.34381850
159ATM0.33344548
160PTK2B0.32840730
161DYRK1B0.32681115
162STK100.32088809
163ABL10.31885090
164GSK3A0.31782677
165MAP2K40.31761321

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.72194827
2Protein export_Homo sapiens_hsa030603.70284355
3Ribosome_Homo sapiens_hsa030102.85029260
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.78888369
5Ether lipid metabolism_Homo sapiens_hsa005652.66571606
6Parkinsons disease_Homo sapiens_hsa050122.63914350
7Alzheimers disease_Homo sapiens_hsa050102.29771954
8Steroid biosynthesis_Homo sapiens_hsa001002.17022454
9Fatty acid elongation_Homo sapiens_hsa000622.14892641
10Sphingolipid metabolism_Homo sapiens_hsa006002.08626759
11Dorso-ventral axis formation_Homo sapiens_hsa043202.01904985
12Huntingtons disease_Homo sapiens_hsa050161.97109097
13RNA polymerase_Homo sapiens_hsa030201.96608657
14Linoleic acid metabolism_Homo sapiens_hsa005911.96224007
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.94775333
16Legionellosis_Homo sapiens_hsa051341.92358120
17Collecting duct acid secretion_Homo sapiens_hsa049661.91400244
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.89766491
19Osteoclast differentiation_Homo sapiens_hsa043801.87446523
20Nicotine addiction_Homo sapiens_hsa050331.71643834
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70681224
22Serotonergic synapse_Homo sapiens_hsa047261.68435951
23Regulation of autophagy_Homo sapiens_hsa041401.67888227
24Basal transcription factors_Homo sapiens_hsa030221.65026477
25B cell receptor signaling pathway_Homo sapiens_hsa046621.61401872
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.60319769
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58837661
28Long-term depression_Homo sapiens_hsa047301.57114558
29TNF signaling pathway_Homo sapiens_hsa046681.51375352
30Arachidonic acid metabolism_Homo sapiens_hsa005901.48162189
31Rheumatoid arthritis_Homo sapiens_hsa053231.48076224
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.48062100
33Leishmaniasis_Homo sapiens_hsa051401.46062510
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43635263
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41356536
36Phototransduction_Homo sapiens_hsa047441.40294615
37Axon guidance_Homo sapiens_hsa043601.40176605
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.37744770
39Vibrio cholerae infection_Homo sapiens_hsa051101.36970129
40Circadian rhythm_Homo sapiens_hsa047101.36811485
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34804079
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34393087
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34108070
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31313882
45T cell receptor signaling pathway_Homo sapiens_hsa046601.30220899
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.28524296
47Sulfur metabolism_Homo sapiens_hsa009201.28141180
48Vitamin B6 metabolism_Homo sapiens_hsa007501.27463728
49Influenza A_Homo sapiens_hsa051641.25406895
50Cardiac muscle contraction_Homo sapiens_hsa042601.25160154
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24625322
52Tuberculosis_Homo sapiens_hsa051521.23320042
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23002173
54Non-homologous end-joining_Homo sapiens_hsa034501.19748885
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18337795
56Measles_Homo sapiens_hsa051621.17729838
57Glutamatergic synapse_Homo sapiens_hsa047241.17004354
58NF-kappa B signaling pathway_Homo sapiens_hsa040641.12821060
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10263748
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.09358022
61FoxO signaling pathway_Homo sapiens_hsa040681.09166521
62Hepatitis B_Homo sapiens_hsa051611.08807552
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05714173
64Prolactin signaling pathway_Homo sapiens_hsa049171.05005145
65Graft-versus-host disease_Homo sapiens_hsa053321.03455253
66Caffeine metabolism_Homo sapiens_hsa002321.01552342
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99333893
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97345864
69Amphetamine addiction_Homo sapiens_hsa050310.95353506
70Estrogen signaling pathway_Homo sapiens_hsa049150.93472327
71Morphine addiction_Homo sapiens_hsa050320.92912360
72Taste transduction_Homo sapiens_hsa047420.91707995
73Cocaine addiction_Homo sapiens_hsa050300.90278400
74Olfactory transduction_Homo sapiens_hsa047400.89275247
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.88361014
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87915548
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87204222
78GABAergic synapse_Homo sapiens_hsa047270.85393471
79Primary immunodeficiency_Homo sapiens_hsa053400.84477647
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83844027
81Autoimmune thyroid disease_Homo sapiens_hsa053200.83572170
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81349853
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80951418
84Phagosome_Homo sapiens_hsa041450.80807901
85Acute myeloid leukemia_Homo sapiens_hsa052210.80180149
86Ras signaling pathway_Homo sapiens_hsa040140.77730594
87Type I diabetes mellitus_Homo sapiens_hsa049400.77600698
88Malaria_Homo sapiens_hsa051440.77453888
89mRNA surveillance pathway_Homo sapiens_hsa030150.76513647
90Pancreatic cancer_Homo sapiens_hsa052120.76331772
91Dopaminergic synapse_Homo sapiens_hsa047280.74640904
92Toxoplasmosis_Homo sapiens_hsa051450.74311078
93Colorectal cancer_Homo sapiens_hsa052100.73591687
94Fatty acid biosynthesis_Homo sapiens_hsa000610.73500313
95MAPK signaling pathway_Homo sapiens_hsa040100.73072601
96Renal cell carcinoma_Homo sapiens_hsa052110.72853768
97Herpes simplex infection_Homo sapiens_hsa051680.71787996
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69995473
99Chemokine signaling pathway_Homo sapiens_hsa040620.69514755
100Long-term potentiation_Homo sapiens_hsa047200.68748150
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.68243443
102Pertussis_Homo sapiens_hsa051330.67518552
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.67304449
104VEGF signaling pathway_Homo sapiens_hsa043700.67297756
105HIF-1 signaling pathway_Homo sapiens_hsa040660.67096682
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66471792
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63979164
108Renin secretion_Homo sapiens_hsa049240.63330347
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62189203
110Synaptic vesicle cycle_Homo sapiens_hsa047210.61861435
111Histidine metabolism_Homo sapiens_hsa003400.60927041
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.58142398
113Homologous recombination_Homo sapiens_hsa034400.57936963
114MicroRNAs in cancer_Homo sapiens_hsa052060.55597468
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55110972
116Insulin resistance_Homo sapiens_hsa049310.55020615
117Prostate cancer_Homo sapiens_hsa052150.54947768
118HTLV-I infection_Homo sapiens_hsa051660.54503052
119Viral carcinogenesis_Homo sapiens_hsa052030.53434227
120Apoptosis_Homo sapiens_hsa042100.53037727
121Staphylococcus aureus infection_Homo sapiens_hsa051500.52248203
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52110688
123Hepatitis C_Homo sapiens_hsa051600.51819273
124Cholinergic synapse_Homo sapiens_hsa047250.51430719
125Proteasome_Homo sapiens_hsa030500.51007432
126Asthma_Homo sapiens_hsa053100.50840431
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.50155140
128Notch signaling pathway_Homo sapiens_hsa043300.49800916
129Thyroid hormone synthesis_Homo sapiens_hsa049180.49378212
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48914009
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48754668
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48203370
133Salivary secretion_Homo sapiens_hsa049700.48138275
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.47627433
135Maturity onset diabetes of the young_Homo sapiens_hsa049500.46625921
136Allograft rejection_Homo sapiens_hsa053300.46303183
137Melanogenesis_Homo sapiens_hsa049160.46287713
138Mineral absorption_Homo sapiens_hsa049780.44742458
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44502073
140Circadian entrainment_Homo sapiens_hsa047130.43487905
141Pancreatic secretion_Homo sapiens_hsa049720.43392624
142Wnt signaling pathway_Homo sapiens_hsa043100.42764506
143Nucleotide excision repair_Homo sapiens_hsa034200.42520994
144Hematopoietic cell lineage_Homo sapiens_hsa046400.42242569
145ErbB signaling pathway_Homo sapiens_hsa040120.42066572
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41780731
147Choline metabolism in cancer_Homo sapiens_hsa052310.41380308
148African trypanosomiasis_Homo sapiens_hsa051430.41067007
149Calcium signaling pathway_Homo sapiens_hsa040200.40251804
150Ovarian steroidogenesis_Homo sapiens_hsa049130.39469195
151Metabolic pathways_Homo sapiens_hsa011000.38894787
152Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38701990
153Fanconi anemia pathway_Homo sapiens_hsa034600.37794974
154cAMP signaling pathway_Homo sapiens_hsa040240.37339703
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.37272332
156Other glycan degradation_Homo sapiens_hsa005110.35615258
157Gastric acid secretion_Homo sapiens_hsa049710.33637138
158Alcoholism_Homo sapiens_hsa050340.32597051
159Hedgehog signaling pathway_Homo sapiens_hsa043400.31538021
160Tight junction_Homo sapiens_hsa045300.30893485
161NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30271510
162Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29174751
163Melanoma_Homo sapiens_hsa052180.27545305
164Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27341089
165Salmonella infection_Homo sapiens_hsa051320.26374654

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