PPA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.50372702
2folic acid-containing compound biosynthetic process (GO:0009396)4.42725726
3purine nucleobase biosynthetic process (GO:0009113)4.34110962
4nucleobase biosynthetic process (GO:0046112)4.32936153
5formation of translation preinitiation complex (GO:0001731)4.05602104
6regulation of mitochondrial translation (GO:0070129)3.91489805
7ATP synthesis coupled proton transport (GO:0015986)3.87701423
8energy coupled proton transport, down electrochemical gradient (GO:0015985)3.87701423
9glycine metabolic process (GO:0006544)3.80468234
10establishment of protein localization to mitochondrial membrane (GO:0090151)3.78389610
11folic acid metabolic process (GO:0046655)3.71882868
12serine family amino acid biosynthetic process (GO:0009070)3.70040078
13CENP-A containing nucleosome assembly (GO:0034080)3.66814454
14cellular glucuronidation (GO:0052695)3.65855553
15chromatin remodeling at centromere (GO:0031055)3.65643602
16IMP biosynthetic process (GO:0006188)3.61594731
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55318571
18protein targeting to mitochondrion (GO:0006626)3.52552337
19tetrahydrofolate metabolic process (GO:0046653)3.51295755
20ribosome biogenesis (GO:0042254)3.48259835
21proteasome assembly (GO:0043248)3.44699890
22chaperone-mediated protein transport (GO:0072321)3.43704728
23ribosomal small subunit biogenesis (GO:0042274)3.42978816
24maturation of 5.8S rRNA (GO:0000460)3.42372647
25ribosome assembly (GO:0042255)3.37190095
26nucleotide-sugar biosynthetic process (GO:0009226)3.36856002
27pteridine-containing compound biosynthetic process (GO:0042559)3.36484219
28respiratory electron transport chain (GO:0022904)3.35313708
29DNA strand elongation involved in DNA replication (GO:0006271)3.35017800
30translation (GO:0006412)3.34113339
31telomere maintenance via recombination (GO:0000722)3.33577028
32cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.31957626
33signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.31022788
34signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.31022788
35signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.31022788
36positive regulation of ligase activity (GO:0051351)3.29332716
37glucuronate metabolic process (GO:0019585)3.29312090
38uronic acid metabolic process (GO:0006063)3.29312090
39protein localization to mitochondrion (GO:0070585)3.28483073
40electron transport chain (GO:0022900)3.28055047
41rRNA metabolic process (GO:0016072)3.26538836
42signal transduction involved in DNA damage checkpoint (GO:0072422)3.25093000
43signal transduction involved in DNA integrity checkpoint (GO:0072401)3.25093000
44deoxyribose phosphate biosynthetic process (GO:0046385)3.23915210
452-deoxyribonucleotide biosynthetic process (GO:0009265)3.23915210
46DNA replication initiation (GO:0006270)3.23508786
47L-serine metabolic process (GO:0006563)3.23478083
48cellular component biogenesis (GO:0044085)3.22971309
49serine family amino acid metabolic process (GO:0009069)3.22793171
50maturation of SSU-rRNA (GO:0030490)3.22244997
51one-carbon metabolic process (GO:0006730)3.22146882
52establishment of protein localization to mitochondrion (GO:0072655)3.21880466
53mitotic recombination (GO:0006312)3.21596735
54signal transduction involved in cell cycle checkpoint (GO:0072395)3.21393147
55DNA strand elongation (GO:0022616)3.20566537
56mitochondrial RNA metabolic process (GO:0000959)3.19787304
57notochord development (GO:0030903)3.19563687
58SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19297837
59DNA damage response, detection of DNA damage (GO:0042769)3.17930450
60cysteine metabolic process (GO:0006534)3.16793651
61cullin deneddylation (GO:0010388)3.16550528
62translational initiation (GO:0006413)3.15919057
63cotranslational protein targeting to membrane (GO:0006613)3.14136713
64regulation of ubiquitin-protein transferase activity (GO:0051438)3.13933676
65erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.12944556
66L-phenylalanine metabolic process (GO:0006558)3.12944556
67IMP metabolic process (GO:0046040)3.12845233
68folic acid-containing compound metabolic process (GO:0006760)3.12314865
69protein deneddylation (GO:0000338)3.12225867
70cartilage condensation (GO:0001502)3.11834129
71cell aggregation (GO:0098743)3.11834129
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.11711070
73proline biosynthetic process (GO:0006561)3.11385141
74pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.11318671
75ribosomal small subunit assembly (GO:0000028)3.09970760
76transcription from mitochondrial promoter (GO:0006390)3.09774563
77protein targeting to ER (GO:0045047)3.08362231
78translational termination (GO:0006415)3.06988475
79DNA unwinding involved in DNA replication (GO:0006268)3.06770302
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.06734357
81ribonucleoprotein complex biogenesis (GO:0022613)3.06594129
82DNA deamination (GO:0045006)3.06401080
83viral transcription (GO:0019083)3.04805807
84serine family amino acid catabolic process (GO:0009071)3.04378092
85transcription elongation from RNA polymerase III promoter (GO:0006385)3.03833153
86termination of RNA polymerase III transcription (GO:0006386)3.03833153
87aldehyde catabolic process (GO:0046185)3.03671458
88DNA catabolic process, exonucleolytic (GO:0000738)3.03556304
89mitochondrial respiratory chain complex assembly (GO:0033108)3.03466510
90ribosomal large subunit biogenesis (GO:0042273)3.02656430
91regulation of ligase activity (GO:0051340)3.02111207
92rRNA modification (GO:0000154)3.02082600
93L-phenylalanine catabolic process (GO:0006559)3.01982585
94erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.01982585
95regulation of cellular amino acid metabolic process (GO:0006521)3.01600595
96establishment of protein localization to endoplasmic reticulum (GO:0072599)3.01593465
97deoxyribonucleotide biosynthetic process (GO:0009263)3.01593078
98mitochondrial respiratory chain complex I assembly (GO:0032981)2.96774384
99NADH dehydrogenase complex assembly (GO:0010257)2.96774384
100mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96774384
101protein localization to endoplasmic reticulum (GO:0070972)2.96676963
102telomere maintenance via semi-conservative replication (GO:0032201)2.95930671
103histone exchange (GO:0043486)2.95279204
104positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94064800
105respiratory chain complex IV assembly (GO:0008535)2.93136201
106sulfur amino acid catabolic process (GO:0000098)2.93075886
107nucleoside salvage (GO:0043174)2.92447003
108pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.91128808
109guanosine-containing compound biosynthetic process (GO:1901070)2.90922625
110spliceosomal snRNP assembly (GO:0000387)2.89810648
111protein complex biogenesis (GO:0070271)2.89792596
112regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89518811
113exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.88523428
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86459366
115establishment of integrated proviral latency (GO:0075713)2.85665733
116triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.85489756
117DNA replication checkpoint (GO:0000076)2.84289679
118nucleobase-containing small molecule interconversion (GO:0015949)2.83987269
119oxidative phosphorylation (GO:0006119)2.82152236
120regulation of translational termination (GO:0006449)2.80075539
121pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.79966715
122UMP biosynthetic process (GO:0006222)2.79966715
123pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.79966715
124UMP metabolic process (GO:0046049)2.79966715
125aromatic amino acid family catabolic process (GO:0009074)2.79323605
126pteridine-containing compound metabolic process (GO:0042558)2.77927507
127urea cycle (GO:0000050)2.77076403
128urea metabolic process (GO:0019627)2.77076403
129nucleoside diphosphate biosynthetic process (GO:0009133)2.76746800
130pseudouridine synthesis (GO:0001522)2.74791941
131glyoxylate metabolic process (GO:0046487)2.74411665
132mitotic metaphase plate congression (GO:0007080)2.73319342
133* tRNA aminoacylation for protein translation (GO:0006418)2.73237695
134sulfur amino acid biosynthetic process (GO:0000097)2.72770718
135negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72735443
136negative regulation of ligase activity (GO:0051352)2.72735443
137chaperone-mediated protein complex assembly (GO:0051131)2.71391113
138* amino acid activation (GO:0043038)2.69268226
139* tRNA aminoacylation (GO:0043039)2.69268226
140mitotic nuclear envelope disassembly (GO:0007077)2.68577049
141AMP metabolic process (GO:0046033)2.67837367
142DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.67257932
143rRNA processing (GO:0006364)2.65663864
144kynurenine metabolic process (GO:0070189)2.64415341
145tryptophan catabolic process (GO:0006569)2.63098775
146indole-containing compound catabolic process (GO:0042436)2.63098775
147indolalkylamine catabolic process (GO:0046218)2.63098775
148signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.62464612
149intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.62464612
150positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.60681370
151L-methionine salvage (GO:0071267)2.60262831
152L-methionine biosynthetic process (GO:0071265)2.60262831
153amino acid salvage (GO:0043102)2.60262831
154oxaloacetate metabolic process (GO:0006107)2.59691209

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.52949695
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.89609523
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.11197768
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.83574959
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.57442322
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.33178674
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.17484354
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17440618
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.07906867
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.04654145
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.01363203
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.97737581
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.95846579
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.55333905
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53558642
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.50195942
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42754754
18E2F1_18555785_ChIP-Seq_MESCs_Mouse2.39568782
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.34311551
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32669396
21AR_21909140_ChIP-Seq_LNCAP_Human2.31393731
22XRN2_22483619_ChIP-Seq_HELA_Human2.27173923
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24919724
24DCP1A_22483619_ChIP-Seq_HELA_Human2.21849507
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.19186480
26RXR_22158963_ChIP-Seq_LIVER_Mouse2.12239227
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.07957475
28VDR_23849224_ChIP-Seq_CD4+_Human2.06423968
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.99751435
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96567761
31PPARA_22158963_ChIP-Seq_LIVER_Mouse1.96377753
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94153186
33* GABP_19822575_ChIP-Seq_HepG2_Human1.92184621
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87686476
35* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86618116
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84680015
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83816512
38FOXP3_21729870_ChIP-Seq_TREG_Human1.79731209
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78918270
40TTF2_22483619_ChIP-Seq_HELA_Human1.75750704
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70430306
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.67503971
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.66535743
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66230998
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61739205
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.61694219
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61375864
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60635722
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.60571379
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.60190879
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.59875830
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58205227
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55417074
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50220136
55ELK1_19687146_ChIP-ChIP_HELA_Human1.49878834
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46297390
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42715350
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41637699
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40276999
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39598680
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35450139
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34697281
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30231784
64LXR_22158963_ChIP-Seq_LIVER_Mouse1.25794229
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24625373
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24304450
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21005091
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19902550
69KDM5A_27292631_Chip-Seq_BREAST_Human1.18283940
70MYC_18940864_ChIP-ChIP_HL60_Human1.16542429
71* ELK1_22589737_ChIP-Seq_MCF10A_Human1.13717311
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09379305
73EWS_26573619_Chip-Seq_HEK293_Human1.07836700
74CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07835090
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06826880
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05671741
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05593001
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04374980
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03845220
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02724670
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01297242
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01148234
83OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00836666
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00740241
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00337212
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99230484
87FUS_26573619_Chip-Seq_HEK293_Human0.99129247
88HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96744166
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94818299
90TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94193946
91SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93347486
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.93254679
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92940744
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92484654
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91765703
96ZNF263_19887448_ChIP-Seq_K562_Human0.90664673
97SALL1_21062744_ChIP-ChIP_HESCs_Human0.88715826
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.88196481
99IGF1R_20145208_ChIP-Seq_DFB_Human0.87867952
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86689122
101TFEB_21752829_ChIP-Seq_HELA_Human0.86364715
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85892426
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85087901
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.84565743
105* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84040280
106* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82213487
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82182122
108CLOCK_20551151_ChIP-Seq_293T_Human0.81736573
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81011369
110ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80433731
111SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.78542858
112* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76606903
113NANOG_16153702_ChIP-ChIP_HESCs_Human0.75552808
114ELF5_23300383_ChIP-Seq_T47D_Human0.74845675
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.74366375
116IRF1_19129219_ChIP-ChIP_H3396_Human0.72828098
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.72597472
118CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.71897272
119* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.69229255
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.68991642
121CIITA_25753668_ChIP-Seq_RAJI_Human0.68494077
122HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.68145837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.75809449
2MP0002139_abnormal_hepatobiliary_system4.97839697
3MP0005360_urolithiasis4.40711910
4MP0003693_abnormal_embryo_hatching3.74952970
5MP0005085_abnormal_gallbladder_physiolo3.68537622
6MP0005365_abnormal_bile_salt3.33330961
7MP0003123_paternal_imprinting3.01888157
8MP0004957_abnormal_blastocyst_morpholog2.94776100
9MP0008875_abnormal_xenobiotic_pharmacok2.81961547
10MP0003646_muscle_fatigue2.74129607
11MP0009697_abnormal_copulation2.49477243
12MP0010094_abnormal_chromosome_stability2.39420839
13MP0003186_abnormal_redox_activity2.37186180
14MP0002282_abnormal_trachea_morphology2.20098207
15MP0004147_increased_porphyrin_level2.13525160
16MP0008058_abnormal_DNA_repair2.09042590
17MP0003111_abnormal_nucleus_morphology2.02711694
18MP0003077_abnormal_cell_cycle1.96585244
19MP0001764_abnormal_homeostasis1.96072915
20MP0003718_maternal_effect1.95551565
21MP0001529_abnormal_vocalization1.91467655
22MP0010329_abnormal_lipoprotein_level1.88677830
23MP0004134_abnormal_chest_morphology1.84538644
24MP0002163_abnormal_gland_morphology1.71466823
25MP0003656_abnormal_erythrocyte_physiolo1.67488161
26MP0002933_joint_inflammation1.58202442
27MP0005332_abnormal_amino_acid1.56765602
28MP0003195_calcinosis1.56564169
29MP0000163_abnormal_cartilage_morphology1.55771838
30MP0009840_abnormal_foam_cell1.54274248
31MP0003283_abnormal_digestive_organ1.53580462
32MP0005083_abnormal_biliary_tract1.52937718
33MP0008057_abnormal_DNA_replication1.52550039
34MP0001666_abnormal_nutrient_absorption1.51725775
35MP0008007_abnormal_cellular_replicative1.51436668
36MP0006036_abnormal_mitochondrial_physio1.50213425
37MP0008995_early_reproductive_senescence1.48552684
38MP0005379_endocrine/exocrine_gland_phen1.48376258
39MP0005319_abnormal_enzyme/_coenzyme1.46344705
40MP0008877_abnormal_DNA_methylation1.46297908
41MP0010352_gastrointestinal_tract_polyps1.41002330
42MP0008932_abnormal_embryonic_tissue1.40912297
43MP0003567_abnormal_fetal_cardiomyocyte1.40207269
44MP0010030_abnormal_orbit_morphology1.39196264
45MP0001730_embryonic_growth_arrest1.38543556
46MP0006292_abnormal_olfactory_placode1.37022855
47MP0006035_abnormal_mitochondrial_morpho1.29106319
48MP0006072_abnormal_retinal_apoptosis1.28387202
49MP0003252_abnormal_bile_duct1.28295930
50MP0009053_abnormal_anal_canal1.27960350
51MP0005266_abnormal_metabolism1.26193701
52MP0002089_abnormal_postnatal_growth/wei1.24995040
53MP0003705_abnormal_hypodermis_morpholog1.23233250
54MP0009250_abnormal_appendicular_skeleto1.22684388
55MP0001929_abnormal_gametogenesis1.21279207
56MP0003011_delayed_dark_adaptation1.17038552
57MP0010234_abnormal_vibrissa_follicle1.16639683
58MP0005645_abnormal_hypothalamus_physiol1.16343754
59MP0004197_abnormal_fetal_growth/weight/1.15807894
60MP0000350_abnormal_cell_proliferation1.14375459
61MP0001727_abnormal_embryo_implantation1.14113370
62MP0002115_abnormal_skeleton_extremities1.13575172
63MP0000609_abnormal_liver_physiology1.13486453
64MP0000647_abnormal_sebaceous_gland1.12148912
65MP0003786_premature_aging1.11155035
66MP0000313_abnormal_cell_death1.10924561
67MP0002234_abnormal_pharynx_morphology1.10025327
68MP0002102_abnormal_ear_morphology1.09771391
69MP0003119_abnormal_digestive_system1.07940651
70MP0001188_hyperpigmentation1.07285223
71MP0000537_abnormal_urethra_morphology1.06743819
72MP0002160_abnormal_reproductive_system1.04178475
73MP0001661_extended_life_span1.02893453
74MP0005187_abnormal_penis_morphology1.02528627
75MP0005376_homeostasis/metabolism_phenot1.00812078
76MP0003890_abnormal_embryonic-extraembry1.00522553
77MP0003315_abnormal_perineum_morphology1.00416366
78MP0002837_dystrophic_cardiac_calcinosis0.99395831
79MP0001881_abnormal_mammary_gland0.96287051
80MP0002111_abnormal_tail_morphology0.95959594
81MP0004782_abnormal_surfactant_physiolog0.95259391
82MP0002113_abnormal_skeleton_development0.94467626
83MP0000762_abnormal_tongue_morphology0.93774391
84MP0003941_abnormal_skin_development0.90423394
85MP0002938_white_spotting0.89738274
86MP0002736_abnormal_nociception_after0.89542916
87MP0005503_abnormal_tendon_morphology0.89230331
88MP0002084_abnormal_developmental_patter0.88877713
89MP0001542_abnormal_bone_strength0.88672397
90MP0000598_abnormal_liver_morphology0.87824555
91MP0001697_abnormal_embryo_size0.87309771
92MP0000678_abnormal_parathyroid_gland0.86441201
93MP0001672_abnormal_embryogenesis/_devel0.84791305
94MP0005380_embryogenesis_phenotype0.84791305
95MP0004019_abnormal_vitamin_homeostasis0.84651127
96MP0003221_abnormal_cardiomyocyte_apopto0.83962362
97MP0005646_abnormal_pituitary_gland0.83210576
98MP0010307_abnormal_tumor_latency0.82106362
99MP0003868_abnormal_feces_composition0.81479717
100MP0000490_abnormal_crypts_of0.79775062
101MP0002080_prenatal_lethality0.78514532
102MP0009046_muscle_twitch0.78195279
103MP0005501_abnormal_skin_physiology0.78036060
104MP0002085_abnormal_embryonic_tissue0.78032473
105MP0009379_abnormal_foot_pigmentation0.77626147
106MP0003698_abnormal_male_reproductive0.75758977
107MP0000631_abnormal_neuroendocrine_gland0.74701818
108MP0003880_abnormal_central_pattern0.74595017
109MP0001119_abnormal_female_reproductive0.74570182
110MP0003984_embryonic_growth_retardation0.74539140
111MP0000358_abnormal_cell_content/0.73850182
112MP0002118_abnormal_lipid_homeostasis0.73152040
113MP0002088_abnormal_embryonic_growth/wei0.72298921
114MP0005023_abnormal_wound_healing0.72199212
115MP0003121_genomic_imprinting0.70692074
116MP0002109_abnormal_limb_morphology0.70227753
117MP0005389_reproductive_system_phenotype0.70224994
118MP0001293_anophthalmia0.69091885
119MP0000566_synostosis0.68948559
120MP0009672_abnormal_birth_weight0.68520040
121MP0002210_abnormal_sex_determination0.67350998
122MP0001986_abnormal_taste_sensitivity0.66063962
123MP0000049_abnormal_middle_ear0.65638539
124MP0005084_abnormal_gallbladder_morpholo0.64734005
125MP0008873_increased_physiological_sensi0.64253227
126MP0002896_abnormal_bone_mineralization0.63891845
127MP0005584_abnormal_enzyme/coenzyme_acti0.63588061
128MP0009765_abnormal_xenobiotic_induced0.63207973
129MP0004215_abnormal_myocardial_fiber0.62730753
130MP0005636_abnormal_mineral_homeostasis0.61995233
131MP0002009_preneoplasia0.61588286
132MP0002086_abnormal_extraembryonic_tissu0.61550671
133MP0002876_abnormal_thyroid_physiology0.61349346
134MP0003937_abnormal_limbs/digits/tail_de0.61051441
135MP0002006_tumorigenesis0.60656050
136MP0008872_abnormal_physiological_respon0.60612805
137MP0005367_renal/urinary_system_phenotyp0.60105544
138MP0000516_abnormal_urinary_system0.60105544
139MP0005670_abnormal_white_adipose0.59369932
140MP0002796_impaired_skin_barrier0.59188253
141MP0002019_abnormal_tumor_incidence0.59137852
142MP0001145_abnormal_male_reproductive0.58722995
143MP0005395_other_phenotype0.58534177
144MP0005408_hypopigmentation0.58486114
145MP0001663_abnormal_digestive_system0.58077139
146MP0000653_abnormal_sex_gland0.56993150
147MP0008789_abnormal_olfactory_epithelium0.56882260
148MP0002909_abnormal_adrenal_gland0.56326225

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)8.41570827
2Epiphyseal dysplasia (HP:0002656)6.96014137
3Vitreoretinal degeneration (HP:0000655)6.48053368
4Abnormal tarsal ossification (HP:0008369)5.93839174
5Small epiphyses (HP:0010585)5.35063537
6Cupped ribs (HP:0000887)5.30652884
7Acute necrotizing encephalopathy (HP:0006965)4.84428403
8Genu varum (HP:0002970)4.79457444
9Abnormal mitochondria in muscle tissue (HP:0008316)4.58794737
10Delayed epiphyseal ossification (HP:0002663)4.55810881
11Flat capital femoral epiphysis (HP:0003370)4.51922208
12Metaphyseal cupping (HP:0003021)4.51914308
13Flat acetabular roof (HP:0003180)4.38330888
14Abnormal foot bone ossification (HP:0010675)4.28343628
15Hypoplastic ischia (HP:0003175)4.25373427
16Increased CSF lactate (HP:0002490)4.21466190
17Progressive macrocephaly (HP:0004481)4.02778892
18Mitochondrial inheritance (HP:0001427)3.96930566
19Carpal bone hypoplasia (HP:0001498)3.94756116
20Arthropathy (HP:0003040)3.81430084
21Abnormality of the ischium (HP:0003174)3.79556814
22Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.77909850
23Abnormality of femoral epiphyses (HP:0006499)3.77909850
24Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.77833514
25Absent epiphyses (HP:0010577)3.77833514
26Increased hepatocellular lipid droplets (HP:0006565)3.69945660
27Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.69793074
28Abnormality of the vertebral endplates (HP:0005106)3.53016752
29Hepatocellular necrosis (HP:0001404)3.51240994
30Hepatic necrosis (HP:0002605)3.50142573
31Abnormality of the epiphysis of the femoral head (HP:0010574)3.47270068
32Irregular vertebral endplates (HP:0003301)3.43044343
33Lipid accumulation in hepatocytes (HP:0006561)3.42539480
34Hypobetalipoproteinemia (HP:0003563)3.38125625
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.37006195
36Abnormality of alanine metabolism (HP:0010916)3.37006195
37Hyperalaninemia (HP:0003348)3.37006195
38Microvesicular hepatic steatosis (HP:0001414)3.28720034
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.26727645
40Decreased activity of mitochondrial respiratory chain (HP:0008972)3.26727645
41Metaphyseal dysplasia (HP:0100255)3.23482975
42Abnormality of the proximal phalanges of the hand (HP:0009834)3.18915000
43Abnormality of the femoral head (HP:0003368)3.11023531
44Lactic acidosis (HP:0003128)3.10755833
45Flattened epiphyses (HP:0003071)3.09484097
46Reticulocytopenia (HP:0001896)3.06363298
47Short femoral neck (HP:0100864)3.05081061
48Mild short stature (HP:0003502)3.00030053
49Metaphyseal irregularity (HP:0003025)2.97910059
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.87256246
513-Methylglutaconic aciduria (HP:0003535)2.82879249
52Chromsome breakage (HP:0040012)2.81357192
53Increased intramyocellular lipid droplets (HP:0012240)2.79342420
54Abnormality of carpal bone ossification (HP:0006257)2.78877968
55Osteoarthritis (HP:0002758)2.76821274
56Neonatal short-limb short stature (HP:0008921)2.74384895
57Intrahepatic cholestasis (HP:0001406)2.73896628
58Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.72761841
59Abnormality of monocarboxylic acid metabolism (HP:0010996)2.69317947
60Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.68849817
61Macrocytic anemia (HP:0001972)2.67790606
62Glossoptosis (HP:0000162)2.61964737
63Respiratory failure (HP:0002878)2.59697296
64Coxa vara (HP:0002812)2.58084049
65Beaking of vertebral bodies (HP:0004568)2.57918389
66Leukodystrophy (HP:0002415)2.57887009
67Exercise intolerance (HP:0003546)2.57628092
68Abnormality of the preputium (HP:0100587)2.56148528
69Degeneration of anterior horn cells (HP:0002398)2.55724955
70Abnormality of the anterior horn cell (HP:0006802)2.55724955
71Type I transferrin isoform profile (HP:0003642)2.54233851
72Stillbirth (HP:0003826)2.54075132
73Vertebral clefting (HP:0008428)2.53215216
74Cerebral hypomyelination (HP:0006808)2.52686922
75Lethargy (HP:0001254)2.50965497
76Hypoglycemic coma (HP:0001325)2.49180749
77Renal Fanconi syndrome (HP:0001994)2.43101356
78Abnormal cartilage morphology (HP:0002763)2.41703724
79Reduced antithrombin III activity (HP:0001976)2.34733858
80Protuberant abdomen (HP:0001538)2.33965824
81Meckel diverticulum (HP:0002245)2.33109443
82Abnormal vertebral ossification (HP:0100569)2.32067669
83Increased muscle lipid content (HP:0009058)2.31186014
84Abnormality of the phalanges of the 2nd finger (HP:0009541)2.27040939
85Platyspondyly (HP:0000926)2.26734537
86Abnormality of aromatic amino acid family metabolism (HP:0004338)2.26577456
87Aplasia/Hypoplasia of the uvula (HP:0010293)2.25076889
88Abnormality of chromosome stability (HP:0003220)2.22880633
89Abnormality of pyrimidine metabolism (HP:0004353)2.22064766
90Abnormality of the ileum (HP:0001549)2.21298554
91Hypolipoproteinemia (HP:0010981)2.20607490
92Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20409310
93CNS demyelination (HP:0007305)2.19156959
94Birth length less than 3rd percentile (HP:0003561)2.18379177
95Abnormality of cells of the erythroid lineage (HP:0012130)2.14029623
96Abnormal protein glycosylation (HP:0012346)2.13594430
97Abnormal glycosylation (HP:0012345)2.13594430
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13594430
99Abnormal protein N-linked glycosylation (HP:0012347)2.13594430
100Abnormality of methionine metabolism (HP:0010901)2.11382205
101Methylmalonic acidemia (HP:0002912)2.11047151
102Enlarged epiphyses (HP:0010580)2.10141123
103Abnormal ossification of hand bones (HP:0005921)2.09319392
104Optic disc pallor (HP:0000543)2.09247354
105Abnormal hand bone ossification (HP:0010660)2.07851433
106Respiratory difficulties (HP:0002880)2.07691363
107Aplasia/hypoplasia of the femur (HP:0005613)2.06880379
108Oral leukoplakia (HP:0002745)2.06605324
109Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.05434289
110Colon cancer (HP:0003003)2.04704756
111Increased serum pyruvate (HP:0003542)2.04088737
112Abnormality of glycolysis (HP:0004366)2.04088737
113Abnormality of the labia minora (HP:0012880)2.04019295
114Pancytopenia (HP:0001876)2.04015590
115Gout (HP:0001997)2.03714837
116Abnormality of the pubic bones (HP:0003172)2.03671768
117Spinal cord compression (HP:0002176)2.03088028
118Hypoplasia of the capital femoral epiphysis (HP:0003090)2.02961897
119Waddling gait (HP:0002515)2.02711038
120Posterior subcapsular cataract (HP:0007787)2.00926790
121Abnormal number of erythroid precursors (HP:0012131)2.00797403
122Methylmalonic aciduria (HP:0012120)1.97838297
123Testicular atrophy (HP:0000029)1.97009999
124Thoracolumbar scoliosis (HP:0002944)1.94397545
125Glycosuria (HP:0003076)1.91447654
126Abnormality of urine glucose concentration (HP:0011016)1.91447654
127Hyperglycinemia (HP:0002154)1.91447506
128Postnatal microcephaly (HP:0005484)1.90932056
129Barrel-shaped chest (HP:0001552)1.90607171
130Microretrognathia (HP:0000308)1.90606294
131Megaloblastic anemia (HP:0001889)1.89544391
132Ovoid vertebral bodies (HP:0003300)1.89421407
133Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89417056
134Mesomelia (HP:0003027)1.88535156
135Fibular hypoplasia (HP:0003038)1.86985038
136Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85817633
137CNS hypomyelination (HP:0003429)1.85511961
138Cerebral edema (HP:0002181)1.85359733
139Abnormality of serine family amino acid metabolism (HP:0010894)1.84856092
140Abnormality of glycine metabolism (HP:0010895)1.84856092
141Abnormality of glutamine family amino acid metabolism (HP:0010902)1.84716712
142Abnormality of sulfur amino acid metabolism (HP:0004339)1.84714101
143Horseshoe kidney (HP:0000085)1.84188191
144Hypokinesia (HP:0002375)1.83176655
145Hyperammonemia (HP:0001987)1.83069135
146Duodenal stenosis (HP:0100867)1.81892266
147Small intestinal stenosis (HP:0012848)1.81892266
148Hyperinsulinemic hypoglycemia (HP:0000825)1.81711927
149Aplastic anemia (HP:0001915)1.80935956
150Limited elbow extension (HP:0001377)1.80327600
151Secondary amenorrhea (HP:0000869)1.79972055
152Triphalangeal thumb (HP:0001199)1.79412911
153Hyperglycinuria (HP:0003108)1.79068988
154Exertional dyspnea (HP:0002875)1.78001348
155Neoplasm of the adrenal gland (HP:0100631)1.77815169
156Dicarboxylic aciduria (HP:0003215)1.77724433
157Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77724433
158Long clavicles (HP:0000890)1.77331631
159Abnormal lung lobation (HP:0002101)1.76365124
160Nausea (HP:0002018)1.75891388
161Abnormality of the vitreous humor (HP:0004327)1.75597607
162Multiple enchondromatosis (HP:0005701)1.75537252
163Aplasia/hypoplasia of the uterus (HP:0008684)1.75072496
164Rough bone trabeculation (HP:0100670)1.74770978
165Abnormality of the phalanges of the 5th finger (HP:0004213)1.74477651
166Generalized aminoaciduria (HP:0002909)1.74158898
167Xanthomatosis (HP:0000991)1.73767215
168Fat malabsorption (HP:0002630)1.72846034
169Vertebral hypoplasia (HP:0008417)1.72626977
170Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.72626977
171Deep venous thrombosis (HP:0002625)1.71301283
172Acute encephalopathy (HP:0006846)1.71276393
173Thin ribs (HP:0000883)1.70727661
174Prolonged partial thromboplastin time (HP:0003645)1.70157580
175Abnormality of incisor morphology (HP:0011063)1.69675781
176Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.69307409
177Palpitations (HP:0001962)1.69058043
178Emotional lability (HP:0000712)1.68808125
179Pallor (HP:0000980)1.68791682
180Cervical subluxation (HP:0003308)1.68417171
181Abnormality of serum amino acid levels (HP:0003112)1.67704767
182Lumbar hyperlordosis (HP:0002938)1.65102153
183Hypoglycemic seizures (HP:0002173)1.64514614
184Neoplasm of the colon (HP:0100273)1.63756618
185Short ribs (HP:0000773)1.62463916
186Abnormality of the acetabulum (HP:0003170)1.61271626
187Abnormality of the 2nd finger (HP:0004100)1.59338404
188Increased serum lactate (HP:0002151)1.58764428

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.01198133
2BUB13.73121282
3BCKDK3.31944405
4STK38L3.21318090
5NME13.04249404
6WEE12.84879725
7CDC72.78673101
8MAP3K32.78509298
9NEK12.53704392
10EIF2AK32.53446729
11SRPK12.46269557
12NME22.41355673
13STK162.14944549
14TSSK62.00245202
15VRK21.94325524
16PLK41.93073141
17PBK1.92992187
18TRIM281.92398042
19MAP3K121.79023119
20DDR21.74711838
21PRKG21.73478677
22STK241.72338566
23TTK1.65117045
24PLK31.63925337
25ACVR1B1.61904298
26EPHA21.54793809
27BRSK21.52172433
28RPS6KB21.51520451
29MST41.49345523
30PLK11.46910553
31MKNK11.44608597
32RPS6KA41.42182496
33CDK191.41158505
34TESK21.41143611
35MAP3K111.41127750
36MKNK21.36994894
37TESK11.29731236
38PASK1.28782392
39AURKB1.26646040
40VRK11.25794405
41PIM21.24953978
42CCNB11.23683206
43BCR1.20115395
44CDK71.19082865
45AURKA1.18668179
46CSNK1G31.17979712
47AKT31.17874235
48CSNK1G11.12969795
49NEK21.11348825
50ATR1.03999784
51ERBB40.99989979
52TGFBR10.97797719
53CSNK1A1L0.94749028
54BRSK10.94267822
55MAPKAPK30.94073130
56NUAK10.93593348
57MAP3K80.92490252
58PDK20.91901722
59CSNK1G20.86759593
60WNK30.85816404
61STK390.84962102
62SCYL20.84928746
63ALK0.82371738
64PLK20.80709120
65CDK40.79864931
66MAP4K20.78747109
67EIF2AK20.78402829
68TLK10.77949542
69MAP2K70.77370375
70MAP3K40.77211821
71LATS20.76714710
72ERBB30.75411333
73PDK30.71936006
74PDK40.71936006
75LIMK10.71252150
76CSNK2A10.70141696
77LATS10.70097024
78ZAK0.69376491
79TAF10.69013933
80CSNK2A20.67679249
81CHEK20.67230429
82ABL20.66653734
83TAOK20.66302558
84BRAF0.62606631
85CHEK10.62151822
86FLT30.62049941
87RPS6KA50.61782612
88PRKCI0.61633601
89PNCK0.60820581
90OXSR10.58945435
91GRK10.57655904
92DYRK30.57635736
93STK40.55593557
94MINK10.54133134
95BMPR20.52289716
96KDR0.52127651
97NEK90.51798945
98ILK0.50824192
99MAP2K30.49934501
100PAK40.48458638
101LMTK20.47243699
102CDK120.46729596
103STK30.46158793
104CLK10.45971318
105ATM0.45929624
106RPS6KB10.44766337
107MAPKAPK50.43997813
108WNK40.43557758
109MAP3K50.42841599
110PIM10.42698888
111CDK20.41885613
112CDK80.41462209
113MST1R0.39867858
114DAPK10.38325546
115CDK140.38104455
116MELK0.37789145
117FRK0.37100469
118CSNK1E0.35930595
119DYRK20.35031776
120STK100.34153020
121CDK30.33905406
122GRK60.33657058
123CDK11A0.33315011
124PINK10.33053020
125CDK180.32590124
126AKT20.30773460
127PKN20.30544702
128BMPR1B0.29831061
129PAK10.29179462
130CSNK1A10.28768443
131CDK150.28481220
132CDK10.28034525
133CAMK2G0.27948165
134DAPK30.27924223
135MAPK40.26092318
136CDK60.25691641
137MAPK110.21461412

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.06517953
2DNA replication_Homo sapiens_hsa030302.71644627
3One carbon pool by folate_Homo sapiens_hsa006702.64637753
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49475052
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.33689614
6Mismatch repair_Homo sapiens_hsa034302.26789889
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.26088933
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12576596
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.11558624
10Ribosome_Homo sapiens_hsa030102.10896999
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.10413170
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09649354
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97129301
14Cysteine and methionine metabolism_Homo sapiens_hsa002701.92634448
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92461469
16Selenocompound metabolism_Homo sapiens_hsa004501.90270226
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.87157344
18RNA polymerase_Homo sapiens_hsa030201.85493073
19Folate biosynthesis_Homo sapiens_hsa007901.84196309
20Biosynthesis of amino acids_Homo sapiens_hsa012301.82369647
21RNA transport_Homo sapiens_hsa030131.81470432
22Pyrimidine metabolism_Homo sapiens_hsa002401.81360836
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80814499
24Arginine biosynthesis_Homo sapiens_hsa002201.75213166
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72361978
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.69472884
27Spliceosome_Homo sapiens_hsa030401.62873420
28Carbon metabolism_Homo sapiens_hsa012001.56284450
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53454550
30Nucleotide excision repair_Homo sapiens_hsa034201.50865325
31Pyruvate metabolism_Homo sapiens_hsa006201.49679164
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.47705150
33Fatty acid elongation_Homo sapiens_hsa000621.45038706
34Base excision repair_Homo sapiens_hsa034101.44920672
35Sulfur metabolism_Homo sapiens_hsa009201.42029722
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36735557
37Propanoate metabolism_Homo sapiens_hsa006401.34100889
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.33264259
39Phenylalanine metabolism_Homo sapiens_hsa003601.28407557
40Tryptophan metabolism_Homo sapiens_hsa003801.26756086
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25530007
42Chemical carcinogenesis_Homo sapiens_hsa052041.25287655
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24757296
44Homologous recombination_Homo sapiens_hsa034401.24725770
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22648275
46Nitrogen metabolism_Homo sapiens_hsa009101.19237485
47Glutathione metabolism_Homo sapiens_hsa004801.16480482
48Starch and sucrose metabolism_Homo sapiens_hsa005001.14896319
49Fatty acid degradation_Homo sapiens_hsa000711.13048859
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12726244
51Peroxisome_Homo sapiens_hsa041461.10918445
52Cell cycle_Homo sapiens_hsa041101.08923954
53Tyrosine metabolism_Homo sapiens_hsa003501.07414880
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07410789
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05051637
56Protein export_Homo sapiens_hsa030601.04854463
57Parkinsons disease_Homo sapiens_hsa050121.04652602
58Sulfur relay system_Homo sapiens_hsa041221.03773154
59beta-Alanine metabolism_Homo sapiens_hsa004101.03134646
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.01743095
61Arginine and proline metabolism_Homo sapiens_hsa003301.00561627
62Complement and coagulation cascades_Homo sapiens_hsa046100.99139246
63Galactose metabolism_Homo sapiens_hsa000520.95972648
64Fructose and mannose metabolism_Homo sapiens_hsa000510.94189922
65* Oxidative phosphorylation_Homo sapiens_hsa001900.94004055
66Retinol metabolism_Homo sapiens_hsa008300.93737067
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93626235
68RNA degradation_Homo sapiens_hsa030180.92951356
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91443071
70Fat digestion and absorption_Homo sapiens_hsa049750.91414322
71Purine metabolism_Homo sapiens_hsa002300.90503174
72Non-homologous end-joining_Homo sapiens_hsa034500.89998187
73Pentose phosphate pathway_Homo sapiens_hsa000300.89904303
74Caffeine metabolism_Homo sapiens_hsa002320.88584662
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87546005
76Butanoate metabolism_Homo sapiens_hsa006500.85071267
77Huntingtons disease_Homo sapiens_hsa050160.80370919
78Steroid biosynthesis_Homo sapiens_hsa001000.77012218
79Basal transcription factors_Homo sapiens_hsa030220.75416291
80Metabolic pathways_Homo sapiens_hsa011000.74540197
81PPAR signaling pathway_Homo sapiens_hsa033200.71210703
82Histidine metabolism_Homo sapiens_hsa003400.70141820
83Protein digestion and absorption_Homo sapiens_hsa049740.68130111
84Oocyte meiosis_Homo sapiens_hsa041140.66894273
85Fatty acid metabolism_Homo sapiens_hsa012120.62116747
86Cardiac muscle contraction_Homo sapiens_hsa042600.61517309
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60510632
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59987704
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58680402
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55108157
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51153202
92Vitamin B6 metabolism_Homo sapiens_hsa007500.49330859
93Fanconi anemia pathway_Homo sapiens_hsa034600.49284777
94Vitamin digestion and absorption_Homo sapiens_hsa049770.48445631
95Systemic lupus erythematosus_Homo sapiens_hsa053220.46041426
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44314867
97Bile secretion_Homo sapiens_hsa049760.41723461
98mRNA surveillance pathway_Homo sapiens_hsa030150.39396535
99ECM-receptor interaction_Homo sapiens_hsa045120.34824396
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.34587412
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32093167
102p53 signaling pathway_Homo sapiens_hsa041150.31728493
103Alzheimers disease_Homo sapiens_hsa050100.31118277
104Alcoholism_Homo sapiens_hsa050340.28336964
105Thyroid cancer_Homo sapiens_hsa052160.27371251
106Asthma_Homo sapiens_hsa053100.26922060
107Vibrio cholerae infection_Homo sapiens_hsa051100.25559446
108Epstein-Barr virus infection_Homo sapiens_hsa051690.25254928
109N-Glycan biosynthesis_Homo sapiens_hsa005100.23233678
110Collecting duct acid secretion_Homo sapiens_hsa049660.22568488
111Regulation of autophagy_Homo sapiens_hsa041400.21852569
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.21834937
113Phototransduction_Homo sapiens_hsa047440.17489703

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