PPA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)5.68882955
2lysine catabolic process (GO:0006554)5.68882955
3L-phenylalanine metabolic process (GO:0006558)5.43317948
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.43317948
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.20797035
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.15868910
7L-phenylalanine catabolic process (GO:0006559)5.15868910
8glyoxylate metabolic process (GO:0046487)5.01220956
9proteasome assembly (GO:0043248)4.94098749
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.66887078
11ATP synthesis coupled proton transport (GO:0015986)4.66887078
12cellular ketone body metabolic process (GO:0046950)4.62320964
13tricarboxylic acid cycle (GO:0006099)4.56158082
14cysteine metabolic process (GO:0006534)4.56014499
15aromatic amino acid family catabolic process (GO:0009074)4.51462168
16oxidative phosphorylation (GO:0006119)4.49787980
17respiratory chain complex IV assembly (GO:0008535)4.48656748
18aspartate family amino acid catabolic process (GO:0009068)4.44257866
19respiratory electron transport chain (GO:0022904)4.31726171
20protein complex biogenesis (GO:0070271)4.26130522
21electron transport chain (GO:0022900)4.22017625
22amino-acid betaine metabolic process (GO:0006577)4.20493544
23CENP-A containing nucleosome assembly (GO:0034080)4.20116656
24chromatin remodeling at centromere (GO:0031055)4.19449721
25short-chain fatty acid metabolic process (GO:0046459)4.18936818
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.16749959
272-oxoglutarate metabolic process (GO:0006103)4.14077527
28serine family amino acid catabolic process (GO:0009071)4.13243124
29glycine metabolic process (GO:0006544)4.12276241
30sulfur amino acid catabolic process (GO:0000098)4.10270976
31mitochondrial respiratory chain complex assembly (GO:0033108)4.09869362
32kynurenine metabolic process (GO:0070189)4.08867389
33serine family amino acid metabolic process (GO:0009069)4.04976639
34serine family amino acid biosynthetic process (GO:0009070)4.04975010
35cytochrome complex assembly (GO:0017004)4.03423159
36ketone body metabolic process (GO:1902224)4.02960579
37fatty acid beta-oxidation (GO:0006635)4.02739075
38establishment of protein localization to mitochondrial membrane (GO:0090151)4.02574037
39indole-containing compound catabolic process (GO:0042436)3.99248603
40indolalkylamine catabolic process (GO:0046218)3.99248603
41tryptophan catabolic process (GO:0006569)3.99248603
42branched-chain amino acid catabolic process (GO:0009083)3.99245295
43drug transmembrane transport (GO:0006855)3.94997895
44carnitine metabolic process (GO:0009437)3.94669815
45DNA double-strand break processing (GO:0000729)3.90440623
46urate metabolic process (GO:0046415)3.89725991
47ethanol oxidation (GO:0006069)3.89326927
48protein neddylation (GO:0045116)3.87126165
49homocysteine metabolic process (GO:0050667)3.75834249
50fatty acid oxidation (GO:0019395)3.74724606
51branched-chain amino acid metabolic process (GO:0009081)3.74714419
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.70963645
53succinate metabolic process (GO:0006105)3.69274404
54cullin deneddylation (GO:0010388)3.68383915
55lipid oxidation (GO:0034440)3.67025568
56NADH metabolic process (GO:0006734)3.66939420
57tryptophan metabolic process (GO:0006568)3.66440848
58alpha-amino acid catabolic process (GO:1901606)3.65883365
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.64863224
60fatty acid catabolic process (GO:0009062)3.63093591
61negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.62873281
62valine metabolic process (GO:0006573)3.59511474
63fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.58297998
64tricarboxylic acid metabolic process (GO:0072350)3.56931841
65cellular amino acid catabolic process (GO:0009063)3.54678702
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.54451312
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.54451312
68acetyl-CoA metabolic process (GO:0006084)3.54372294
69positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.50113441
70drug transport (GO:0015893)3.48939869
71aromatic amino acid family metabolic process (GO:0009072)3.48108087
72regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45990249
73bile acid biosynthetic process (GO:0006699)3.44082352
74oxaloacetate metabolic process (GO:0006107)3.43776425
75DNA deamination (GO:0045006)3.41087228
76protein deneddylation (GO:0000338)3.40909049
77rRNA modification (GO:0000154)3.40128714
78monocarboxylic acid catabolic process (GO:0072329)3.39424820
79purine nucleobase biosynthetic process (GO:0009113)3.37366360
80histone exchange (GO:0043486)3.37307624
81aldehyde catabolic process (GO:0046185)3.35362253
82carboxylic acid catabolic process (GO:0046395)3.34947783
83organic acid catabolic process (GO:0016054)3.34947783
84response to mercury ion (GO:0046689)3.33102034
85triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.28441080
86regulation of cellular amino acid metabolic process (GO:0006521)3.28084194
87chaperone-mediated protein transport (GO:0072321)3.26520467
88anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24039704
89drug catabolic process (GO:0042737)3.22700183
90DNA ligation (GO:0006266)3.21705062
91negative regulation of ligase activity (GO:0051352)3.21604393
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.21604393
93DNA catabolic process, exonucleolytic (GO:0000738)3.19262078
94maturation of 5.8S rRNA (GO:0000460)3.18837079
95regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.18405002
96glutamate metabolic process (GO:0006536)3.17819493
97peptidyl-histidine modification (GO:0018202)3.16524087
98alpha-linolenic acid metabolic process (GO:0036109)3.15607060
99dicarboxylic acid metabolic process (GO:0043648)3.14268238
100ATP biosynthetic process (GO:0006754)3.14222242
101water-soluble vitamin biosynthetic process (GO:0042364)3.13885236
102urea cycle (GO:0000050)3.13326968
103urea metabolic process (GO:0019627)3.13326968
104L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.12894744
105deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.12258007
106flavonoid metabolic process (GO:0009812)3.12078952
107histone mRNA metabolic process (GO:0008334)3.11364758
108phosphate ion transmembrane transport (GO:0035435)3.09606690
109DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07996031
110telomere maintenance via semi-conservative replication (GO:0032201)3.05801757
111replication fork processing (GO:0031297)3.05546181
112pteridine-containing compound biosynthetic process (GO:0042559)3.05013679
113signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.04887870
114signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.04887870
115signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.04887870
116cellular modified amino acid catabolic process (GO:0042219)3.04803482
117pseudouridine synthesis (GO:0001522)3.04259357
118folic acid metabolic process (GO:0046655)3.03970994
119positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.03209066
120sulfur amino acid metabolic process (GO:0000096)3.03027567
121nitrogen cycle metabolic process (GO:0071941)3.01668084
122aspartate family amino acid metabolic process (GO:0009066)3.01621990
123intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.01233685
124signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.01233685
125regulation of acyl-CoA biosynthetic process (GO:0050812)3.00933133
126RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.00221131
127L-serine metabolic process (GO:0006563)2.99820647
128NADH dehydrogenase complex assembly (GO:0010257)2.98861765
129mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.98861765
130mitochondrial respiratory chain complex I assembly (GO:0032981)2.98861765
131phosphate ion transport (GO:0006817)2.98056745
132protein targeting to mitochondrion (GO:0006626)2.97842369
133regulation of mitotic spindle checkpoint (GO:1903504)2.96835569
134regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.96835569
135establishment of integrated proviral latency (GO:0075713)2.96826279
136regulation of coenzyme metabolic process (GO:0051196)2.95920003
137regulation of cofactor metabolic process (GO:0051193)2.95920003
138inner mitochondrial membrane organization (GO:0007007)2.94980880
139regulation of mitochondrial translation (GO:0070129)2.94347752
140benzene-containing compound metabolic process (GO:0042537)2.94122485
141purine nucleoside triphosphate biosynthetic process (GO:0009145)2.93606421
142DNA replication-independent nucleosome organization (GO:0034724)2.93300842
143DNA replication-independent nucleosome assembly (GO:0006336)2.93300842
144DNA damage response, detection of DNA damage (GO:0042769)2.93232102
145positive regulation of ligase activity (GO:0051351)2.91700542
146aerobic respiration (GO:0009060)2.91587985
147signal transduction involved in cell cycle checkpoint (GO:0072395)2.91499915
148nucleobase biosynthetic process (GO:0046112)2.90726612
149rRNA methylation (GO:0031167)2.90682019
150quinone biosynthetic process (GO:1901663)2.90440840
151ubiquinone biosynthetic process (GO:0006744)2.90440840
152aminoglycoside antibiotic metabolic process (GO:0030647)2.90391508
153small molecule catabolic process (GO:0044282)2.90301397
154signal transduction involved in DNA damage checkpoint (GO:0072422)2.90263867
155signal transduction involved in DNA integrity checkpoint (GO:0072401)2.90263867
156deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.89486068
157viral transcription (GO:0019083)2.88845740
158protein localization to mitochondrion (GO:0070585)2.88179604
159regulation of triglyceride catabolic process (GO:0010896)2.87938520
160quaternary ammonium group transport (GO:0015697)2.87881809
161exogenous drug catabolic process (GO:0042738)2.86859809
162somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.85034646
163isotype switching (GO:0045190)2.85034646
164somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.85034646
165GMP metabolic process (GO:0046037)2.83676278
166mannosylation (GO:0097502)2.82997198
167platelet dense granule organization (GO:0060155)2.80845821
168nucleotide-excision repair, DNA gap filling (GO:0006297)2.75718573
169establishment of protein localization to mitochondrion (GO:0072655)2.74472318
170DNA replication checkpoint (GO:0000076)2.74015116
171pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.73013049
172preassembly of GPI anchor in ER membrane (GO:0016254)2.72172283
173termination of RNA polymerase III transcription (GO:0006386)2.72088438
174transcription elongation from RNA polymerase III promoter (GO:0006385)2.72088438
175protein-cofactor linkage (GO:0018065)2.70933772
176telomere maintenance via recombination (GO:0000722)2.70524126
177GTP biosynthetic process (GO:0006183)2.70432026
178organelle disassembly (GO:1903008)2.70047041
179L-methionine salvage (GO:0071267)2.69344689
180L-methionine biosynthetic process (GO:0071265)2.69344689
181amino acid salvage (GO:0043102)2.69344689
182DNA strand elongation involved in DNA replication (GO:0006271)2.68508558
183ribosome assembly (GO:0042255)2.68131847
184intracellular protein transmembrane import (GO:0044743)2.68021314
185mitochondrial RNA metabolic process (GO:0000959)2.67344590
186ribosomal large subunit biogenesis (GO:0042273)2.67082094

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.56562147
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.79124993
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.23482319
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.10283368
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.71550983
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.57432594
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25689261
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.16868591
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.10188426
10ELK1_19687146_ChIP-ChIP_HELA_Human3.06129907
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90701719
12* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.69884825
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69456246
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.67546872
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.63055138
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54864595
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.53856333
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.53235575
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.51773479
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.48483287
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46960961
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.40136887
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.32182690
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.25729274
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12583060
26* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11922009
27* ZNF274_21170338_ChIP-Seq_K562_Hela2.07773763
28* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04013146
29E2F7_22180533_ChIP-Seq_HELA_Human2.02947641
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99777183
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98148847
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.97710684
33EWS_26573619_Chip-Seq_HEK293_Human1.96710166
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96475865
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.94598095
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.94032719
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.92521358
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.92468354
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89361625
40XRN2_22483619_ChIP-Seq_HELA_Human1.88830041
41FUS_26573619_Chip-Seq_HEK293_Human1.88221215
42IGF1R_20145208_ChIP-Seq_DFB_Human1.88139529
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.87888388
44DCP1A_22483619_ChIP-Seq_HELA_Human1.87270230
45VDR_22108803_ChIP-Seq_LS180_Human1.82625235
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77605016
47AR_21909140_ChIP-Seq_LNCAP_Human1.68246606
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63878022
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63684871
50* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59741106
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.59349978
52VDR_23849224_ChIP-Seq_CD4+_Human1.58981030
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57110942
54* GABP_19822575_ChIP-Seq_HepG2_Human1.56293897
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52636602
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52072431
57ZNF263_19887448_ChIP-Seq_K562_Human1.51949758
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47252255
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44980190
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44075763
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43754373
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.43657516
63FOXP3_21729870_ChIP-Seq_TREG_Human1.42358389
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41840624
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36558897
66* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34204231
67P300_19829295_ChIP-Seq_ESCs_Human1.33857828
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33002902
69TAF15_26573619_Chip-Seq_HEK293_Human1.31964650
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31448873
71* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30507001
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.29956544
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28226955
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23128889
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22011022
76IRF1_19129219_ChIP-ChIP_H3396_Human1.21996524
77TTF2_22483619_ChIP-Seq_HELA_Human1.21968202
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19120414
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18537860
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17809645
81* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17455432
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15162091
83KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13881795
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13548909
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12586084
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12570170
87TP53_22573176_ChIP-Seq_HFKS_Human1.12300896
88NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10473071
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10316522
90* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09953031
91POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08622961
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08461377
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08343972
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08234151
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08125564
96HTT_18923047_ChIP-ChIP_STHdh_Human1.08014857
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07849558
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07823317
99CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06330876
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.06182416
101ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05338429
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05103848
103ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03968965
104SOX2_19829295_ChIP-Seq_ESCs_Human1.03276027
105NANOG_19829295_ChIP-Seq_ESCs_Human1.03276027
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03260405
107FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02957358
108FOXA1_25329375_ChIP-Seq_VCAP_Human1.02957358
109ER_23166858_ChIP-Seq_MCF-7_Human1.02735830
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02671194
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00968884
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.00165806
113SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00111308
114MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99623655
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.98060911
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97706510
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96541433
118E2F4_17652178_ChIP-ChIP_JURKAT_Human0.96071370
119* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95769867
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93738790
121MYC_18940864_ChIP-ChIP_HL60_Human0.93546350
122IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93529524
123CBP_20019798_ChIP-Seq_JUKART_Human0.93529524
124TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93131445
125FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93024213
126AR_20517297_ChIP-Seq_VCAP_Human0.92726196
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92538523
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92295698
129SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92114043
130KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91145925
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89823027
132OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89688951
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88981011
134PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87743502
135YY1_22570637_ChIP-Seq_MALME-3M_Human0.87698027
136CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87679674
137RXRA_24833708_ChIP-Seq_LIVER_Mouse0.82437490
138FOXP1_21924763_ChIP-Seq_HESCs_Human0.80879648
139PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79635906
140GATA1_22025678_ChIP-Seq_K562_Human0.78577606
141TET1_21451524_ChIP-Seq_MESCs_Mouse0.78154231
142SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77638144
143HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77098856
144ERG_20517297_ChIP-Seq_VCAP_Human0.75027528
145* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.74813905
146KDM5A_27292631_Chip-Seq_BREAST_Human0.74669981
147ELK1_22589737_ChIP-Seq_MCF10A_Human0.72953925
148SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.70868564
149RBPJ_22232070_ChIP-Seq_NCS_Mouse0.70771327
150TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.70116374

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.52521154
2MP0005360_urolithiasis6.10860129
3MP0003806_abnormal_nucleotide_metabolis5.24357742
4MP0005085_abnormal_gallbladder_physiolo4.76909830
5MP0008875_abnormal_xenobiotic_pharmacok4.37570485
6MP0005365_abnormal_bile_salt4.28956227
7MP0008058_abnormal_DNA_repair3.64186678
8MP0010094_abnormal_chromosome_stability3.42088826
9MP0005332_abnormal_amino_acid3.27572415
10MP0006036_abnormal_mitochondrial_physio3.01815036
11MP0006072_abnormal_retinal_apoptosis2.91464407
12MP0002837_dystrophic_cardiac_calcinosis2.81495848
13MP0008057_abnormal_DNA_replication2.62424097
14MP0003786_premature_aging2.57581206
15MP0003646_muscle_fatigue2.48841053
16MP0003195_calcinosis2.42782186
17MP0000372_irregular_coat_pigmentation2.35491361
18MP0001764_abnormal_homeostasis2.31682735
19MP0010329_abnormal_lipoprotein_level2.29438577
20MP0003252_abnormal_bile_duct2.29109889
21MP0003186_abnormal_redox_activity2.27350727
22MP0004019_abnormal_vitamin_homeostasis2.27016643
23MP0004043_abnormal_pH_regulation2.13373265
24MP0008877_abnormal_DNA_methylation2.07028631
25MP0002102_abnormal_ear_morphology2.05985828
26MP0005083_abnormal_biliary_tract2.02725498
27MP0009643_abnormal_urine_homeostasis1.99938908
28MP0008789_abnormal_olfactory_epithelium1.99813964
29MP0001666_abnormal_nutrient_absorption1.92265730
30MP0005075_abnormal_melanosome_morpholog1.91728124
31MP0006035_abnormal_mitochondrial_morpho1.91271980
32MP0003011_delayed_dark_adaptation1.90373098
33MP0005319_abnormal_enzyme/_coenzyme1.87408159
34MP0004215_abnormal_myocardial_fiber1.85046270
35MP0002938_white_spotting1.82463357
36MP0005636_abnormal_mineral_homeostasis1.80221711
37MP0009840_abnormal_foam_cell1.79771137
38MP0008995_early_reproductive_senescence1.79187532
39MP0005253_abnormal_eye_physiology1.76302704
40MP0003077_abnormal_cell_cycle1.72380040
41MP0005584_abnormal_enzyme/coenzyme_acti1.72263376
42MP0002138_abnormal_hepatobiliary_system1.70113781
43MP0004084_abnormal_cardiac_muscle1.65292329
44MP0005330_cardiomyopathy1.64648415
45MP0003787_abnormal_imprinting1.60035052
46MP0003111_abnormal_nucleus_morphology1.54803879
47MP0005645_abnormal_hypothalamus_physiol1.53357996
48MP0002118_abnormal_lipid_homeostasis1.52532382
49MP0008932_abnormal_embryonic_tissue1.50299909
50MP0000516_abnormal_urinary_system1.48358668
51MP0005367_renal/urinary_system_phenotyp1.48358668
52MP0000609_abnormal_liver_physiology1.47095898
53MP0005646_abnormal_pituitary_gland1.43991904
54MP0005266_abnormal_metabolism1.41716792
55MP0003656_abnormal_erythrocyte_physiolo1.40882441
56MP0002163_abnormal_gland_morphology1.38957716
57MP0003121_genomic_imprinting1.37059275
58MP0004036_abnormal_muscle_relaxation1.33523081
59MP0000427_abnormal_hair_cycle1.32832604
60MP0008007_abnormal_cellular_replicative1.32379473
61MP0002090_abnormal_vision1.30241257
62MP0003191_abnormal_cellular_cholesterol1.28753499
63MP0003693_abnormal_embryo_hatching1.27582538
64MP0004147_increased_porphyrin_level1.27301813
65MP0006292_abnormal_olfactory_placode1.24940215
66MP0000751_myopathy1.22360764
67MP0004957_abnormal_blastocyst_morpholog1.20503683
68MP0000631_abnormal_neuroendocrine_gland1.19748929
69MP0009697_abnormal_copulation1.15451390
70MP0004133_heterotaxia1.13842526
71MP0005376_homeostasis/metabolism_phenot1.13793202
72MP0001756_abnormal_urination1.13322570
73MP0003221_abnormal_cardiomyocyte_apopto1.12875525
74MP0002269_muscular_atrophy1.12316021
75MP0001765_abnormal_ion_homeostasis1.10842121
76MP0002234_abnormal_pharynx_morphology1.10767255
77MP0000647_abnormal_sebaceous_gland1.10748451
78MP0005394_taste/olfaction_phenotype1.10133461
79MP0005499_abnormal_olfactory_system1.10133461
80MP0002095_abnormal_skin_pigmentation1.08984912
81MP0002736_abnormal_nociception_after1.07520749
82MP0003868_abnormal_feces_composition1.07298693
83MP0001984_abnormal_olfaction1.06568942
84MP0005379_endocrine/exocrine_gland_phen1.06474777
85MP0010386_abnormal_urinary_bladder1.05200692
86MP0002160_abnormal_reproductive_system1.02909878
87MP0003941_abnormal_skin_development1.01825670
88MP0005670_abnormal_white_adipose1.01424605
89MP0004130_abnormal_muscle_cell1.01029632
90MP0000383_abnormal_hair_follicle0.99614652
91MP0000747_muscle_weakness0.98353929
92MP0001929_abnormal_gametogenesis0.96497256
93MP0001293_anophthalmia0.96480592
94MP0001485_abnormal_pinna_reflex0.96290714
95MP0001727_abnormal_embryo_implantation0.95715354
96MP0002210_abnormal_sex_determination0.94704662
97MP0009046_muscle_twitch0.92947721
98MP0000598_abnormal_liver_morphology0.92355667
99MP0000653_abnormal_sex_gland0.92054636
100MP0000749_muscle_degeneration0.91877073
101MP0008775_abnormal_heart_ventricle0.91733466
102MP0005084_abnormal_gallbladder_morpholo0.91689016
103MP0003890_abnormal_embryonic-extraembry0.90769445
104MP0001661_extended_life_span0.90211144
105MP0009379_abnormal_foot_pigmentation0.89845751
106MP0005377_hearing/vestibular/ear_phenot0.88407722
107MP0003878_abnormal_ear_physiology0.88407722
108MP0003880_abnormal_central_pattern0.86690793
109MP0002751_abnormal_autonomic_nervous0.86382669
110MP0001145_abnormal_male_reproductive0.86250231
111MP0006276_abnormal_autonomic_nervous0.85968430
112MP0008872_abnormal_physiological_respon0.85953317
113MP0010678_abnormal_skin_adnexa0.84969648
114MP0005666_abnormal_adipose_tissue0.84387662
115MP0003137_abnormal_impulse_conducting0.84279008
116MP0002136_abnormal_kidney_physiology0.82200331
117MP0002277_abnormal_respiratory_mucosa0.81786451
118MP0005395_other_phenotype0.80589192
119MP0005535_abnormal_body_temperature0.80445232
120MP0002876_abnormal_thyroid_physiology0.79095524
121MP0002822_catalepsy0.77858407
122MP0005389_reproductive_system_phenotype0.77649816
123MP0002972_abnormal_cardiac_muscle0.77325226
124MP0000750_abnormal_muscle_regeneration0.77103346
125MP0004233_abnormal_muscle_weight0.76980012
126MP0009642_abnormal_blood_homeostasis0.76004945
127MP0002078_abnormal_glucose_homeostasis0.75766816
128MP0000230_abnormal_systemic_arterial0.75253200
129MP0005385_cardiovascular_system_phenoty0.74660659
130MP0001544_abnormal_cardiovascular_syste0.74660659
131MP0001119_abnormal_female_reproductive0.73766239
132MP0001853_heart_inflammation0.72937602
133MP0004142_abnormal_muscle_tone0.72304538
134MP0005165_increased_susceptibility_to0.71860368
135MP0000358_abnormal_cell_content/0.71585830
136MP0004087_abnormal_muscle_fiber0.70507717
137MP0003718_maternal_effect0.70093876
138MP0005647_abnormal_sex_gland0.69054125
139MP0002233_abnormal_nose_morphology0.67969745
140MP0005391_vision/eye_phenotype0.65196608
141MP0005410_abnormal_fertilization0.63538197
142MP0005620_abnormal_muscle_contractility0.63365737
143MP0009780_abnormal_chondrocyte_physiolo0.62807752
144MP0003937_abnormal_limbs/digits/tail_de0.61197885
145MP0001905_abnormal_dopamine_level0.60689133
146MP0005195_abnormal_posterior_eye0.59375741
147MP0005220_abnormal_exocrine_pancreas0.58125490
148MP0008469_abnormal_protein_level0.55883607
149MP0009763_increased_sensitivity_to0.54662395
150MP0001529_abnormal_vocalization0.54102839
151MP0000538_abnormal_urinary_bladder0.53044244
152MP0005451_abnormal_body_composition0.52789893
153MP0005551_abnormal_eye_electrophysiolog0.52239258
154MP0006138_congestive_heart_failure0.51231235
155MP0003638_abnormal_response/metabolism_0.51165361
156MP0002971_abnormal_brown_adipose0.50386998
157MP0010630_abnormal_cardiac_muscle0.50230208
158MP0008873_increased_physiological_sensi0.49945524
159MP0002638_abnormal_pupillary_reflex0.49795579
160MP0003567_abnormal_fetal_cardiomyocyte0.49633859
161MP0004484_altered_response_of0.48748747
162MP0005408_hypopigmentation0.47740431
163MP0005334_abnormal_fat_pad0.47175586
164MP0004145_abnormal_muscle_electrophysio0.47100405
165MP0002332_abnormal_exercise_endurance0.45070226
166MP0003315_abnormal_perineum_morphology0.44922352

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.77342195
2Acute encephalopathy (HP:0006846)4.60807315
3Hepatic necrosis (HP:0002605)4.55043626
4Abnormal mitochondria in muscle tissue (HP:0008316)4.44759899
5Acute necrotizing encephalopathy (HP:0006965)4.40734344
6Cerebral edema (HP:0002181)4.39429220
7Hyperglycinuria (HP:0003108)4.38565325
8Hyperammonemia (HP:0001987)4.16466920
9Hepatocellular necrosis (HP:0001404)4.14728280
10Dicarboxylic aciduria (HP:0003215)4.12705115
11Abnormality of dicarboxylic acid metabolism (HP:0010995)4.12705115
12Ketosis (HP:0001946)4.09565502
13Hyperglycinemia (HP:0002154)4.09529641
14Abnormality of fatty-acid metabolism (HP:0004359)4.08588339
15Abnormality of serine family amino acid metabolism (HP:0010894)4.07651616
16Abnormality of glycine metabolism (HP:0010895)4.07651616
17Mitochondrial inheritance (HP:0001427)3.87435571
18Ketoacidosis (HP:0001993)3.84469538
19Gout (HP:0001997)3.78568760
20Increased CSF lactate (HP:0002490)3.78047930
21Hypoglycemic coma (HP:0001325)3.74265409
22Intrahepatic cholestasis (HP:0001406)3.70937347
23Lethargy (HP:0001254)3.67910347
24Generalized aminoaciduria (HP:0002909)3.60180998
25Abnormality of monocarboxylic acid metabolism (HP:0010996)3.56220511
26Progressive macrocephaly (HP:0004481)3.54629056
27Lactic acidosis (HP:0003128)3.53024073
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.52256186
29Decreased activity of mitochondrial respiratory chain (HP:0008972)3.52256186
30Proximal tubulopathy (HP:0000114)3.47062000
31Delayed CNS myelination (HP:0002188)3.38026040
32Hypobetalipoproteinemia (HP:0003563)3.35224466
33Increased muscle lipid content (HP:0009058)3.26545881
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.22963691
35Abnormality of aspartate family amino acid metabolism (HP:0010899)3.19702140
36Abnormality of serum amino acid levels (HP:0003112)3.10937105
37Xanthomatosis (HP:0000991)3.10107513
38Abnormality of glycolysis (HP:0004366)3.10063851
39Increased serum pyruvate (HP:0003542)3.10063851
40Metabolic acidosis (HP:0001942)3.08719451
41Increased intramyocellular lipid droplets (HP:0012240)3.06389463
42Increased serum lactate (HP:0002151)2.98738007
43Type I transferrin isoform profile (HP:0003642)2.96418211
44Hyperuricemia (HP:0002149)2.95721172
45Increased purine levels (HP:0004368)2.95721172
46Respiratory failure (HP:0002878)2.94606602
473-Methylglutaconic aciduria (HP:0003535)2.94390863
48Methylmalonic aciduria (HP:0012120)2.91813197
49Vomiting (HP:0002013)2.90555121
50Myoglobinuria (HP:0002913)2.90128605
51Abnormality of glutamine family amino acid metabolism (HP:0010902)2.89771550
52Glycosuria (HP:0003076)2.89094795
53Abnormality of urine glucose concentration (HP:0011016)2.89094795
54Lipid accumulation in hepatocytes (HP:0006561)2.81686158
55Abnormality of purine metabolism (HP:0004352)2.75335660
56Ragged-red muscle fibers (HP:0003200)2.67896271
57Congenital, generalized hypertrichosis (HP:0004540)2.66056702
58Abnormality of methionine metabolism (HP:0010901)2.65676811
59Abnormality of nucleobase metabolism (HP:0010932)2.63383468
60Abnormality of sulfur amino acid metabolism (HP:0004339)2.60954664
61Rhabdomyolysis (HP:0003201)2.59406192
62Abnormal protein glycosylation (HP:0012346)2.58752563
63Abnormal glycosylation (HP:0012345)2.58752563
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.58752563
65Abnormal protein N-linked glycosylation (HP:0012347)2.58752563
66Hypolipoproteinemia (HP:0010981)2.58658927
67Hyperphosphaturia (HP:0003109)2.55343353
68Medial flaring of the eyebrow (HP:0010747)2.53627536
69CNS demyelination (HP:0007305)2.53031566
70Hyperlipoproteinemia (HP:0010980)2.52504385
71Exercise intolerance (HP:0003546)2.51796845
72Deep venous thrombosis (HP:0002625)2.51728932
73Prolonged partial thromboplastin time (HP:0003645)2.50506218
74Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49305586
75Pancreatic cysts (HP:0001737)2.48215712
76Exertional dyspnea (HP:0002875)2.41626862
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.40102770
78Abnormality of alanine metabolism (HP:0010916)2.40102770
79Hyperalaninemia (HP:0003348)2.40102770
80Abnormality of pyrimidine metabolism (HP:0004353)2.39479086
81Nausea (HP:0002018)2.38710319
82Colon cancer (HP:0003003)2.38141941
83Increased hepatocellular lipid droplets (HP:0006565)2.37940967
84Reduced antithrombin III activity (HP:0001976)2.37931993
85Pancreatic fibrosis (HP:0100732)2.35494281
86Palpitations (HP:0001962)2.34367107
87Neoplasm of the adrenal gland (HP:0100631)2.33326468
88Hyperbilirubinemia (HP:0002904)2.32160132
89Abnormality of midbrain morphology (HP:0002418)2.31301932
90Molar tooth sign on MRI (HP:0002419)2.31301932
91Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.27300280
92Optic disc pallor (HP:0000543)2.24891303
93Constricted visual fields (HP:0001133)2.24824272
94Abnormality of cells of the erythroid lineage (HP:0012130)2.22168883
95True hermaphroditism (HP:0010459)2.21279613
96Volvulus (HP:0002580)2.20435251
97Hypoalphalipoproteinemia (HP:0003233)2.20343654
98Abnormality of chromosome stability (HP:0003220)2.18671166
99Late onset (HP:0003584)2.17099932
100Brushfield spots (HP:0001088)2.16682603
101Abolished electroretinogram (ERG) (HP:0000550)2.15740986
102Renal Fanconi syndrome (HP:0001994)2.15307563
103Alkalosis (HP:0001948)2.13103919
104Renal cortical cysts (HP:0000803)2.12899691
105Abnormal number of erythroid precursors (HP:0012131)2.10481501
106Congenital primary aphakia (HP:0007707)2.10393621
107Abnormal gallbladder physiology (HP:0012438)2.08939560
108Cholecystitis (HP:0001082)2.08939560
109Leukodystrophy (HP:0002415)2.07122645
110Malnutrition (HP:0004395)2.07053035
111Abnormality of renal resorption (HP:0011038)2.06483532
112Abnormality of the labia minora (HP:0012880)2.05017255
113Nephronophthisis (HP:0000090)2.03308927
114Abnormality of the heme biosynthetic pathway (HP:0010472)2.02225326
115Neonatal onset (HP:0003623)2.01934436
116Abnormality of vitamin B metabolism (HP:0004340)2.01930452
117Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01418831
118Aplasia/Hypoplasia of the uvula (HP:0010293)1.99918708
119Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99912859
120Microvesicular hepatic steatosis (HP:0001414)1.99570180
121Abnormal urine phosphate concentration (HP:0012599)1.99120923
122Hyperactive renin-angiotensin system (HP:0000841)1.97821827
123Meckel diverticulum (HP:0002245)1.95546227
124Nephrogenic diabetes insipidus (HP:0009806)1.94769505
125Methylmalonic acidemia (HP:0002912)1.94639521
126Abnormality of macular pigmentation (HP:0008002)1.93855827
127Gait imbalance (HP:0002141)1.91719320
128Abnormality of the anterior horn cell (HP:0006802)1.91000149
129Degeneration of anterior horn cells (HP:0002398)1.91000149
130Hypothermia (HP:0002045)1.90806400
131Multiple enchondromatosis (HP:0005701)1.90410945
132Macrocytic anemia (HP:0001972)1.90358783
133Fat malabsorption (HP:0002630)1.89984820
134Emotional lability (HP:0000712)1.89755731
135Aplasia/hypoplasia of the uterus (HP:0008684)1.89176350
136Attenuation of retinal blood vessels (HP:0007843)1.87697908
137Hypomagnesemia (HP:0002917)1.86575897
138Abnormality of the vitamin B12 metabolism (HP:0004341)1.86150132
139Respiratory difficulties (HP:0002880)1.86149448
140Megaloblastic anemia (HP:0001889)1.84745745
141Abnormality of the preputium (HP:0100587)1.84677337
142Abnormality of the ileum (HP:0001549)1.82845179
143Abnormality of the renal cortex (HP:0011035)1.82478222
144Hyperinsulinemic hypoglycemia (HP:0000825)1.81796792
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.75589706
146Tubulointerstitial nephritis (HP:0001970)1.70991597
147Neoplasm of the adrenal cortex (HP:0100641)1.70979782
148Aplastic anemia (HP:0001915)1.69156005
149Metaphyseal dysplasia (HP:0100255)1.66849415
150Hypoglycemic seizures (HP:0002173)1.66229344
151Sclerocornea (HP:0000647)1.64968630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.64747975
2NEK13.52763612
3PDK43.49801374
4PDK33.49801374
5NME23.13535171
6VRK23.08240789
7ACVR1B2.94008857
8MAP4K22.92538108
9NUAK12.85906042
10EIF2AK12.81703021
11ZAK2.59910029
12STK162.55718035
13FRK2.53506830
14WEE12.44948396
15MST1R2.44024314
16WNK42.41001467
17TESK22.35136227
18WNK32.31481948
19MAP3K122.31340842
20BUB12.23291739
21MYLK2.20507943
22PBK2.19314101
23PLK42.15792596
24FLT32.14311202
25TRIM281.95979671
26KDR1.91579597
27PDK21.85198837
28ERBB31.84954438
29PIK3CA1.80823661
30TLK11.80464177
31MKNK11.79177919
32MKNK21.66962323
33PINK11.66356429
34NME11.66098001
35PLK31.59907746
36BCR1.50567510
37SCYL21.48669964
38TESK11.48466409
39OXSR11.45205781
40GRK11.42173473
41LMTK21.42133714
42CSNK1G31.39834164
43EIF2AK31.38732650
44DYRK31.32584202
45CDK191.32458511
46CSNK1G11.29650105
47PKN21.23837019
48CSNK1G21.22038496
49MAP3K111.11557953
50CSNK1A1L1.10905426
51TAF11.08255182
52PIK3CG1.08179045
53MAPKAPK31.07215837
54STK38L1.05161377
55ADRBK21.02633029
56BRSK21.01939936
57INSRR0.98444134
58VRK10.98065190
59STK390.97577192
60MAP3K40.96898027
61OBSCN0.92045499
62MAP2K70.91948745
63ILK0.89599753
64MAP2K40.84675875
65CCNB10.84607270
66EIF2AK20.83668001
67CDK80.82755223
68PIM20.81796861
69PLK20.79909148
70TGFBR10.79413094
71BRAF0.79409684
72ATR0.77255296
73RPS6KB20.74476757
74PHKG10.72163551
75PHKG20.72163551
76ARAF0.71603719
77LRRK20.71436850
78MAP2K20.71180942
79DAPK30.70369983
80KIT0.67258243
81MET0.67154086
82AURKA0.67016877
83MAPK130.65610777
84KSR20.65376540
85SRPK10.65325407
86PASK0.65120527
87PAK40.65063178
88LIMK10.64985064
89MST40.64632005
90CASK0.60709943
91RPS6KA50.57750304
92MAP3K80.57736028
93PRKCE0.56734252
94CHEK20.55544813
95ATM0.55304314
96AURKB0.55111494
97DYRK20.55067501
98SIK10.54543003
99MAP2K10.53671278
100GRK60.52596725
101ABL20.51486099
102TTN0.49708275
103STK30.48932894
104MAPK110.48573858
105NEK20.48007532
106MAP3K50.47373206
107CAMK2G0.47337741
108TNIK0.46945085
109BMPR20.46720953
110MAP2K30.46205722
111PRKCI0.45745745
112CDC70.45381407
113RAF10.44897837
114CSNK2A20.44839819
115TAOK30.44814813
116MAPKAPK50.44536958
117DAPK10.44509607
118TSSK60.41618923
119ERN10.41472471
120CSNK2A10.40684260
121PLK10.40490845
122CSNK1A10.40369418
123CAMK2D0.40297308
124TIE10.39783807
125PRKCG0.39043757
126TTK0.37626886
127MAP2K60.37330294
128AKT20.35773913
129MAP3K20.29828608
130MUSK0.29404049
131TEC0.29119684
132RPS6KA40.28907297
133BRSK10.28852602
134MAP3K70.28120010
135CDK30.27989998
136IKBKB0.27942019
137NEK90.27908828
138CDK70.27781365
139PRKAA20.27271460
140PRKG20.27248730
141PRKACG0.26470883
142ADRBK10.26468665
143BMPR1B0.25905855
144MAPK40.25783844

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.03510730
2Propanoate metabolism_Homo sapiens_hsa006403.00763930
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.96351877
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.75461490
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.73409024
6Fatty acid degradation_Homo sapiens_hsa000712.72984235
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.44616082
8* Oxidative phosphorylation_Homo sapiens_hsa001902.43787221
9Pyruvate metabolism_Homo sapiens_hsa006202.41055397
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.36461002
11Butanoate metabolism_Homo sapiens_hsa006502.30311640
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.26437292
13Parkinsons disease_Homo sapiens_hsa050122.25741319
14Carbon metabolism_Homo sapiens_hsa012002.20591635
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14115820
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.07233671
17Tryptophan metabolism_Homo sapiens_hsa003802.00338698
18Non-homologous end-joining_Homo sapiens_hsa034501.95305776
19Peroxisome_Homo sapiens_hsa041461.94116113
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85433388
21Arginine biosynthesis_Homo sapiens_hsa002201.85327937
22Nitrogen metabolism_Homo sapiens_hsa009101.84949952
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84211329
24Fatty acid metabolism_Homo sapiens_hsa012121.83287693
25Ribosome_Homo sapiens_hsa030101.82665446
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79563169
27Fanconi anemia pathway_Homo sapiens_hsa034601.78198257
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.77871169
29Biosynthesis of amino acids_Homo sapiens_hsa012301.74559796
30Basal transcription factors_Homo sapiens_hsa030221.72189652
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.68944205
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.66308325
33Folate biosynthesis_Homo sapiens_hsa007901.61573070
34beta-Alanine metabolism_Homo sapiens_hsa004101.55790077
35Sulfur metabolism_Homo sapiens_hsa009201.55437820
36Sulfur relay system_Homo sapiens_hsa041221.54523804
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.50936632
38Huntingtons disease_Homo sapiens_hsa050161.50404758
39Selenocompound metabolism_Homo sapiens_hsa004501.47757947
40Alzheimers disease_Homo sapiens_hsa050101.45068462
41Proteasome_Homo sapiens_hsa030501.41829117
42Fatty acid elongation_Homo sapiens_hsa000621.40743939
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40162742
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.39973829
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35765047
46PPAR signaling pathway_Homo sapiens_hsa033201.29898094
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25468558
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25079100
49Pentose phosphate pathway_Homo sapiens_hsa000301.22226867
50Chemical carcinogenesis_Homo sapiens_hsa052041.21395861
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16698600
52Glutathione metabolism_Homo sapiens_hsa004801.15828251
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11862242
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11334375
55Phenylalanine metabolism_Homo sapiens_hsa003601.11227804
56Histidine metabolism_Homo sapiens_hsa003401.11029603
57Cardiac muscle contraction_Homo sapiens_hsa042601.08710755
58DNA replication_Homo sapiens_hsa030301.08651649
59Arginine and proline metabolism_Homo sapiens_hsa003301.05606872
60Caffeine metabolism_Homo sapiens_hsa002321.05591017
61One carbon pool by folate_Homo sapiens_hsa006701.04724306
62Tyrosine metabolism_Homo sapiens_hsa003501.02425545
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99809724
64Starch and sucrose metabolism_Homo sapiens_hsa005000.98999031
65Bile secretion_Homo sapiens_hsa049760.96624183
66Pyrimidine metabolism_Homo sapiens_hsa002400.94049038
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.93566386
68Retinol metabolism_Homo sapiens_hsa008300.93395090
69Metabolic pathways_Homo sapiens_hsa011000.85851547
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85712839
71Cell cycle_Homo sapiens_hsa041100.81179020
72Complement and coagulation cascades_Homo sapiens_hsa046100.80649092
73Fructose and mannose metabolism_Homo sapiens_hsa000510.80144923
74Asthma_Homo sapiens_hsa053100.77672077
75Mismatch repair_Homo sapiens_hsa034300.75921320
76RNA polymerase_Homo sapiens_hsa030200.72552923
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66271317
78N-Glycan biosynthesis_Homo sapiens_hsa005100.64246863
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62224797
80Fat digestion and absorption_Homo sapiens_hsa049750.59850719
81Galactose metabolism_Homo sapiens_hsa000520.56033725
82Regulation of autophagy_Homo sapiens_hsa041400.55788305
83Glycerolipid metabolism_Homo sapiens_hsa005610.55724160
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.55295607
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54371038
86Vitamin digestion and absorption_Homo sapiens_hsa049770.53612565
87Linoleic acid metabolism_Homo sapiens_hsa005910.49548872
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46130125
89Oocyte meiosis_Homo sapiens_hsa041140.44331839
90Arachidonic acid metabolism_Homo sapiens_hsa005900.44201161
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41900138
92Lysine degradation_Homo sapiens_hsa003100.39082810
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39004610
94Purine metabolism_Homo sapiens_hsa002300.38301583
95Vitamin B6 metabolism_Homo sapiens_hsa007500.38154349
96ABC transporters_Homo sapiens_hsa020100.37785074
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37467426
98p53 signaling pathway_Homo sapiens_hsa041150.36702448
99Nucleotide excision repair_Homo sapiens_hsa034200.36187800
100Protein export_Homo sapiens_hsa030600.34658132
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.33391974
102Ether lipid metabolism_Homo sapiens_hsa005650.32190910
103Spliceosome_Homo sapiens_hsa030400.31591942
104Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30249057
105Homologous recombination_Homo sapiens_hsa034400.28576164
106Type I diabetes mellitus_Homo sapiens_hsa049400.28568684
107Base excision repair_Homo sapiens_hsa034100.25996964
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25553213
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24685877
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22751799
111RNA transport_Homo sapiens_hsa030130.21786740
112Glucagon signaling pathway_Homo sapiens_hsa049220.20974437
113Steroid biosynthesis_Homo sapiens_hsa001000.20703743
114Fatty acid biosynthesis_Homo sapiens_hsa000610.13512498
115Phototransduction_Homo sapiens_hsa047440.08191739
116Thyroid cancer_Homo sapiens_hsa052160.08044895
117Mineral absorption_Homo sapiens_hsa049780.04238159
118RNA degradation_Homo sapiens_hsa030180.03833379
119Systemic lupus erythematosus_Homo sapiens_hsa053220.03645144
120Renin-angiotensin system_Homo sapiens_hsa046140.02863273
121Collecting duct acid secretion_Homo sapiens_hsa049660.02822659
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.02274151

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