PPARA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.10111231
2L-phenylalanine catabolic process (GO:0006559)7.10111231
3L-phenylalanine metabolic process (GO:0006558)6.79348277
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.79348277
5aromatic amino acid family catabolic process (GO:0009074)6.40180813
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.11597962
7alpha-linolenic acid metabolic process (GO:0036109)5.79717369
8indole-containing compound catabolic process (GO:0042436)5.79661019
9indolalkylamine catabolic process (GO:0046218)5.79661019
10tryptophan catabolic process (GO:0006569)5.79661019
11kynurenine metabolic process (GO:0070189)5.77562331
12bile acid biosynthetic process (GO:0006699)5.70910042
13glyoxylate metabolic process (GO:0046487)5.64265749
14tryptophan metabolic process (GO:0006568)5.46958181
15urea metabolic process (GO:0019627)5.37639186
16urea cycle (GO:0000050)5.37639186
17negative regulation of fibrinolysis (GO:0051918)5.22929552
18high-density lipoprotein particle remodeling (GO:0034375)5.19652694
19cysteine metabolic process (GO:0006534)5.13102593
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.11603145
21complement activation, alternative pathway (GO:0006957)5.07946120
22peptidyl-glutamic acid carboxylation (GO:0017187)5.05707035
23protein carboxylation (GO:0018214)5.05707035
24regulation of fibrinolysis (GO:0051917)5.05611995
25sulfur amino acid catabolic process (GO:0000098)5.04636673
26regulation of protein activation cascade (GO:2000257)5.03822198
27regulation of triglyceride catabolic process (GO:0010896)4.97591396
28lysine catabolic process (GO:0006554)4.96857294
29lysine metabolic process (GO:0006553)4.96857294
30nitrogen cycle metabolic process (GO:0071941)4.94818843
31serine family amino acid catabolic process (GO:0009071)4.92022161
32bile acid metabolic process (GO:0008206)4.91087499
33amino-acid betaine metabolic process (GO:0006577)4.84536541
34exogenous drug catabolic process (GO:0042738)4.70465627
35regulation of complement activation (GO:0030449)4.69823686
36homocysteine metabolic process (GO:0050667)4.68160863
37aromatic amino acid family metabolic process (GO:0009072)4.64675619
38cellular ketone body metabolic process (GO:0046950)4.61337991
39regulation of cholesterol esterification (GO:0010872)4.60173519
40reverse cholesterol transport (GO:0043691)4.59518099
41protein-lipid complex remodeling (GO:0034368)4.56393684
42macromolecular complex remodeling (GO:0034367)4.56393684
43plasma lipoprotein particle remodeling (GO:0034369)4.56393684
44acylglycerol homeostasis (GO:0055090)4.55973045
45triglyceride homeostasis (GO:0070328)4.55973045
46alpha-amino acid catabolic process (GO:1901606)4.52824754
47tyrosine metabolic process (GO:0006570)4.48273770
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.35922930
49phospholipid efflux (GO:0033700)4.35054258
50plasma lipoprotein particle clearance (GO:0034381)4.32004546
51sulfation (GO:0051923)4.31752538
52negative regulation of sterol transport (GO:0032372)4.29025708
53negative regulation of cholesterol transport (GO:0032375)4.29025708
54bile acid and bile salt transport (GO:0015721)4.24782298
55coenzyme catabolic process (GO:0009109)4.23994110
56flavonoid metabolic process (GO:0009812)4.22290399
57cellular amino acid catabolic process (GO:0009063)4.19752342
58cellular glucuronidation (GO:0052695)4.19132664
59glycine metabolic process (GO:0006544)4.12644389
60ethanol oxidation (GO:0006069)4.12602749
61indolalkylamine metabolic process (GO:0006586)4.09926924
62glutamate metabolic process (GO:0006536)4.09475651
63acetyl-CoA metabolic process (GO:0006084)4.05978489
64short-chain fatty acid metabolic process (GO:0046459)4.04969953
65cholesterol efflux (GO:0033344)4.04238084
66cellular biogenic amine catabolic process (GO:0042402)3.99937965
67amine catabolic process (GO:0009310)3.99937965
68fatty acid beta-oxidation (GO:0006635)3.99271951
69ketone body metabolic process (GO:1902224)3.98913779
70serine family amino acid metabolic process (GO:0009069)3.96002637
71imidazole-containing compound metabolic process (GO:0052803)3.94709037
72cellular modified amino acid catabolic process (GO:0042219)3.94337713
73dicarboxylic acid biosynthetic process (GO:0043650)3.93620385
74benzene-containing compound metabolic process (GO:0042537)3.93061219
75phospholipid homeostasis (GO:0055091)3.92661806
76fatty acid oxidation (GO:0019395)3.88767050
77water-soluble vitamin biosynthetic process (GO:0042364)3.88765384
78plasma lipoprotein particle assembly (GO:0034377)3.86593246
79cell proliferation in forebrain (GO:0021846)3.86381499
80drug catabolic process (GO:0042737)3.85781377
81low-density lipoprotein particle remodeling (GO:0034374)3.85710986
82organic acid catabolic process (GO:0016054)3.85049104
83carboxylic acid catabolic process (GO:0046395)3.85049104
84lipid oxidation (GO:0034440)3.81740903
85monocarboxylic acid catabolic process (GO:0072329)3.81732467
86carnitine metabolic process (GO:0009437)3.80819075
87fatty acid catabolic process (GO:0009062)3.78910950
88serotonin metabolic process (GO:0042428)3.77530077
89negative regulation of lipase activity (GO:0060192)3.76738450
90fibrinolysis (GO:0042730)3.75643861
91arginine metabolic process (GO:0006525)3.73943750
92aspartate family amino acid catabolic process (GO:0009068)3.73574488
93cellular response to ATP (GO:0071318)3.73318253
942-oxoglutarate metabolic process (GO:0006103)3.72699123
95cholesterol homeostasis (GO:0042632)3.71952615
96uronic acid metabolic process (GO:0006063)3.71933890
97glucuronate metabolic process (GO:0019585)3.71933890
98* positive regulation of lipid catabolic process (GO:0050996)3.69827580
99regulation of bile acid biosynthetic process (GO:0070857)3.69430934
100very-low-density lipoprotein particle assembly (GO:0034379)3.67436227
101aldehyde catabolic process (GO:0046185)3.66903644
102serine family amino acid biosynthetic process (GO:0009070)3.66121904
103sterol homeostasis (GO:0055092)3.66061572
104positive regulation of triglyceride lipase activity (GO:0061365)3.65484583
105positive regulation of lipoprotein lipase activity (GO:0051006)3.65484583
106regulation of cholesterol homeostasis (GO:2000188)3.62707591
107primary amino compound metabolic process (GO:1901160)3.62391739
108cofactor catabolic process (GO:0051187)3.59832778
109blood coagulation, intrinsic pathway (GO:0007597)3.59637284
110epoxygenase P450 pathway (GO:0019373)3.59409774
111oxidative demethylation (GO:0070989)3.49497884
112gamma-aminobutyric acid transport (GO:0015812)3.46307522
113otic vesicle formation (GO:0030916)3.46259589
114indole-containing compound metabolic process (GO:0042430)3.41662433
115opsonization (GO:0008228)3.41555619
116cellular anion homeostasis (GO:0030002)3.38780821
117regulation of skeletal muscle contraction (GO:0014819)3.37528465
118membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.32078894
119negative regulation of systemic arterial blood pressure (GO:0003085)3.25302088
120response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.24275454
1213-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.20128525
122purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.20128525
123omega-hydroxylase P450 pathway (GO:0097267)3.12764370
124membrane repolarization during action potential (GO:0086011)3.12344717
125regulation of membrane repolarization (GO:0060306)3.11254470
126negative regulation of protein localization to cell surface (GO:2000009)3.04433991
127* behavioral response to nicotine (GO:0035095)3.02624889
128drug metabolic process (GO:0017144)2.97603025
129positive regulation of cardiac muscle cell differentiation (GO:2000727)2.97241398
130alkaloid metabolic process (GO:0009820)2.90234002
131* positive regulation of fatty acid oxidation (GO:0046321)2.89635845
132parturition (GO:0007567)2.83068701
133plasma membrane repair (GO:0001778)2.81634111
134regulation of action potential (GO:0098900)2.76731751
135somite development (GO:0061053)2.74731621
136response to inactivity (GO:0014854)2.74452283
137membrane depolarization during action potential (GO:0086010)2.73353778
138vitamin biosynthetic process (GO:0009110)2.72860936
139regulation of glomerulus development (GO:0090192)2.72228121
140pharyngeal system development (GO:0060037)2.64852466
141negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.58631643
142positive regulation of fatty acid transport (GO:2000193)2.57733084
143vitamin catabolic process (GO:0009111)2.53252427
144fat-soluble vitamin catabolic process (GO:0042363)2.53252427
145regulation of hippo signaling (GO:0035330)2.52179665
146response to muscle activity (GO:0014850)2.48690717
147cellular response to exogenous dsRNA (GO:0071360)2.47000234
148heme transport (GO:0015886)2.46128278
149multicellular organismal signaling (GO:0035637)2.42411845
150epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.39549126
151regulation of potassium ion transmembrane transport (GO:1901379)2.38827503
152membrane repolarization (GO:0086009)2.36397864
153neuronal action potential (GO:0019228)2.36335111
154cardiac conduction (GO:0061337)2.33827545
155positive regulation of sodium ion transmembrane transport (GO:1902307)2.32574982
156regulation of female receptivity (GO:0045924)2.32560160
157sarcomere organization (GO:0045214)2.31253586
158detection of light stimulus involved in visual perception (GO:0050908)2.30851460
159detection of light stimulus involved in sensory perception (GO:0050962)2.30851460
160sulfate transmembrane transport (GO:1902358)2.30707510
161transmission of nerve impulse (GO:0019226)2.30469898
162positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.30432555
163ethanol metabolic process (GO:0006067)2.28979432
164regulation of potassium ion transmembrane transporter activity (GO:1901016)2.28342367
165interkinetic nuclear migration (GO:0022027)2.26890395
166myofibril assembly (GO:0030239)2.26589339
167regulation of heart rate by cardiac conduction (GO:0086091)2.26243617
168lymphangiogenesis (GO:0001946)2.25892837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.11361485
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.98752814
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.55972263
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.37192809
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.79658606
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.19200938
7EZH2_22144423_ChIP-Seq_EOC_Human4.97778843
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.70168531
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.08364157
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.59406661
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72130500
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.54477441
13GBX2_23144817_ChIP-Seq_PC3_Human2.24952735
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07326321
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.04356145
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03649029
17* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4231282
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98091471
19VDR_22108803_ChIP-Seq_LS180_Human1.96681857
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87824450
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.84259379
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76981611
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76447628
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75192372
25CLOCK_20551151_ChIP-Seq_293T_Human1.73581112
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.71746081
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.71040880
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70423130
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68827003
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67687255
31FOXA2_19822575_ChIP-Seq_HepG2_Human1.65685427
32* EZH2_27294783_Chip-Seq_ESCs_Mouse1.65111543
33ZNF274_21170338_ChIP-Seq_K562_Hela1.61610812
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58256917
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53250260
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53250260
37* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52576938
38DROSHA_22980978_ChIP-Seq_HELA_Human1.48625091
39GATA1_22025678_ChIP-Seq_K562_Human1.48539964
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46627889
41* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46624581
42* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44034974
43HTT_18923047_ChIP-ChIP_STHdh_Human1.43563355
44* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41288642
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40733151
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40171262
47* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39739940
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.37910085
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37279157
50REST_21632747_ChIP-Seq_MESCs_Mouse1.35518066
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34986838
52IRF1_19129219_ChIP-ChIP_H3396_Human1.34455138
53* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33318382
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30133520
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27868015
56STAT3_23295773_ChIP-Seq_U87_Human1.26302733
57* PIAS1_25552417_ChIP-Seq_VCAP_Human1.25393840
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23838016
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23589634
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21214157
61SMAD4_21799915_ChIP-Seq_A2780_Human1.19753650
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19073282
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18786137
64ER_23166858_ChIP-Seq_MCF-7_Human1.18398745
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18208095
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17878578
67TP53_16413492_ChIP-PET_HCT116_Human1.16124064
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15304774
69* TCF4_23295773_ChIP-Seq_U87_Human1.13489643
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12732283
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12547172
72P300_19829295_ChIP-Seq_ESCs_Human1.12158026
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10603016
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10278576
75CBP_20019798_ChIP-Seq_JUKART_Human1.10278576
76CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08710987
77RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07901549
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07183089
79P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05994814
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05488002
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05488002
82IGF1R_20145208_ChIP-Seq_DFB_Human1.05415295
83RNF2_27304074_Chip-Seq_NSC_Mouse1.05348767
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04570766
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04306697
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03830755
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03144127
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.02794250
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02211091
90FUS_26573619_Chip-Seq_HEK293_Human1.01951782
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01227251
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00892905
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.00246632
94AR_25329375_ChIP-Seq_VCAP_Human0.99633815
95EP300_21415370_ChIP-Seq_HL-1_Mouse0.99071096
96SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98997533
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98563642
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.98518181
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98447011
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98208616
101FLI1_27457419_Chip-Seq_LIVER_Mouse0.98041339
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.97597360
103RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97538786
104TP53_20018659_ChIP-ChIP_R1E_Mouse0.97420110
105TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97066064
106TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96989784
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96836602
108* SOX2_21211035_ChIP-Seq_LN229_Gbm0.96805578
109PRDM14_20953172_ChIP-Seq_ESCs_Human0.96751243
110KDM2B_26808549_Chip-Seq_REH_Human0.96168616
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96008374
112RXR_22108803_ChIP-Seq_LS180_Human0.95535614
113SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94866851
114AHR_22903824_ChIP-Seq_MCF-7_Human0.93967252
115NCOR_22424771_ChIP-Seq_293T_Human0.93833583
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93537002
117TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93193626
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92063260
119ZNF263_19887448_ChIP-Seq_K562_Human0.91364631
120* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87969073
121AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87560134
122GATA4_25053715_ChIP-Seq_YYC3_Human0.85964683
123ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83881178
124ESR2_21235772_ChIP-Seq_MCF-7_Human0.79353373
125IRF8_22096565_ChIP-ChIP_GC-B_Human0.77341662
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77332786
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76546988
128AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76445985
129SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74332917
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72891682
131NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72891682
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70719832
133ESR1_20079471_ChIP-ChIP_T-47D_Human0.68501447
134NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.67379842
135KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67198813
136PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.66247923
137PPAR_26484153_Chip-Seq_NCI-H1993_Human0.65406852
138RARA_24833708_ChIP-Seq_LIVER_Mouse0.65016443
139* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64121262
140RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62565575
141CEBPB_22108803_ChIP-Seq_LS180_Human0.62249838
142EGR1_19032775_ChIP-ChIP_M12_Human0.60960163
143BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59940392
144RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59082004
145PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.58762822
146FOXA1_25552417_ChIP-Seq_VCAP_Human0.57174189
147FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.54909152
148CDX2_20551321_ChIP-Seq_CACO-2_Human0.54902286
149BCAT_22108803_ChIP-Seq_LS180_Human0.54364192
150PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54003896
151RARB_24833708_ChIP-Seq_LIVER_Mouse0.53965607
152NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.52923051
153FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52641194
154ESR1_21235772_ChIP-Seq_MCF-7_Human0.52390772
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.52371392
156CBP_21632823_ChIP-Seq_H3396_Human0.52313067
157* AR_20517297_ChIP-Seq_VCAP_Human0.49865268
158STAT3_1855785_ChIP-Seq_MESCs_Mouse0.49258551
159* TBX20_22328084_ChIP-Seq_HEART_Mouse0.49069786
160* TBX20_22080862_ChIP-Seq_HEART_Mouse0.49069786
161GATA1_19941826_ChIP-Seq_K562_Human0.48258292
162ESET_19884257_ChIP-Seq_ESCs_Mouse0.48171051
163STAT1_17558387_ChIP-Seq_HELA_Human0.48087268
164GATA2_19941826_ChIP-Seq_K562_Human0.47472484
165ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.47161331
166LXR_22292898_ChIP-Seq_THP-1_Human0.46898571
167MYC_19915707_ChIP-ChIP_AK7_Human0.45754254
168E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.45519371
169FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45400720
170GATA6_25053715_ChIP-Seq_YYC3_Human0.43887049
171TAF15_26573619_Chip-Seq_HEK293_Human0.43744313
172EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.43236476
173TAF2_19829295_ChIP-Seq_ESCs_Human0.42545752
174CDX2_22108803_ChIP-Seq_LS180_Human0.42052203
175GATA1_19941827_ChIP-Seq_MEL_Mouse0.41922197
176P53_21459846_ChIP-Seq_SAOS-2_Human0.41870530
177PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40743748
178CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40236622
179GATA3_24758297_ChIP-Seq_MCF-7_Human0.39585667
180PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.38011853
181TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.37989527
182FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.37820726
183* SOX2_20726797_ChIP-Seq_SW620_Human0.37336114
184MYC_27129775_Chip-Seq_CORNEA_Mouse0.37137211
185SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36500407
186* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.36468450
187ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.34907484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.06585396
2MP0005360_urolithiasis7.36982355
3MP0005085_abnormal_gallbladder_physiolo6.36140665
4MP0005365_abnormal_bile_salt6.11266481
5MP0008875_abnormal_xenobiotic_pharmacok4.99615671
6MP0003806_abnormal_nucleotide_metabolis4.02102826
7MP0003252_abnormal_bile_duct3.89937983
8MP0004145_abnormal_muscle_electrophysio3.78779832
9* MP0010329_abnormal_lipoprotein_level3.52057033
10MP0009840_abnormal_foam_cell3.11252003
11MP0005083_abnormal_biliary_tract3.02049659
12MP0005332_abnormal_amino_acid2.84582110
13MP0003195_calcinosis2.82146801
14MP0001666_abnormal_nutrient_absorption2.58520583
15MP0003191_abnormal_cellular_cholesterol2.23543919
16* MP0002118_abnormal_lipid_homeostasis2.20642289
17* MP0000609_abnormal_liver_physiology2.16716828
18MP0001485_abnormal_pinna_reflex2.14916586
19MP0004019_abnormal_vitamin_homeostasis2.13694536
20MP0003879_abnormal_hair_cell2.10306029
21MP0002160_abnormal_reproductive_system1.97389441
22MP0002138_abnormal_hepatobiliary_system1.88999969
23MP0005319_abnormal_enzyme/_coenzyme1.86353335
24MP0006292_abnormal_olfactory_placode1.86014525
25MP0003868_abnormal_feces_composition1.86007858
26MP0008775_abnormal_heart_ventricle1.83366102
27MP0009379_abnormal_foot_pigmentation1.73808864
28MP0005646_abnormal_pituitary_gland1.67573282
29MP0004885_abnormal_endolymph1.66522064
30MP0005584_abnormal_enzyme/coenzyme_acti1.63863813
31MP0004142_abnormal_muscle_tone1.63572139
32MP0001764_abnormal_homeostasis1.59615796
33MP0005451_abnormal_body_composition1.53934961
34MP0005670_abnormal_white_adipose1.53825027
35MP0003011_delayed_dark_adaptation1.48067467
36MP0009697_abnormal_copulation1.47785935
37MP0005551_abnormal_eye_electrophysiolog1.45764400
38MP0001440_abnormal_grooming_behavior1.32869898
39MP0002272_abnormal_nervous_system1.30813301
40MP0004134_abnormal_chest_morphology1.30563358
41MP0009643_abnormal_urine_homeostasis1.29665453
42MP0005620_abnormal_muscle_contractility1.29344372
43MP0003186_abnormal_redox_activity1.25226139
44* MP0004215_abnormal_myocardial_fiber1.24904245
45MP0005389_reproductive_system_phenotype1.24423523
46MP0000049_abnormal_middle_ear1.21794602
47MP0002106_abnormal_muscle_physiology1.21111569
48MP0002638_abnormal_pupillary_reflex1.18456802
49MP0009745_abnormal_behavioral_response1.17459340
50MP0000631_abnormal_neuroendocrine_gland1.17306991
51MP0003705_abnormal_hypodermis_morpholog1.15699593
52MP0003656_abnormal_erythrocyte_physiolo1.15055391
53MP0002733_abnormal_thermal_nociception1.13987716
54MP0002837_dystrophic_cardiac_calcinosis1.12242777
55* MP0000598_abnormal_liver_morphology1.11923783
56MP0004036_abnormal_muscle_relaxation1.11437887
57MP0000678_abnormal_parathyroid_gland1.09665540
58MP0006036_abnormal_mitochondrial_physio1.09349401
59MP0003136_yellow_coat_color1.09117925
60MP0001968_abnormal_touch/_nociception1.08787592
61MP0005647_abnormal_sex_gland1.08371212
62MP0002254_reproductive_system_inflammat1.08325689
63MP0002971_abnormal_brown_adipose1.08139051
64MP0000569_abnormal_digit_pigmentation1.06530801
65MP0010368_abnormal_lymphatic_system1.05426815
66MP0000026_abnormal_inner_ear1.04982127
67MP0004085_abnormal_heartbeat1.04842830
68MP0002064_seizures1.01781335
69MP0004084_abnormal_cardiac_muscle1.01325564
70MP0009764_decreased_sensitivity_to1.01200182
71MP0005369_muscle_phenotype1.01091200
72MP0009250_abnormal_appendicular_skeleto1.00979153
73MP0000604_amyloidosis0.99529525
74MP0002249_abnormal_larynx_morphology0.99356144
75* MP0009763_increased_sensitivity_to0.96227515
76MP0005666_abnormal_adipose_tissue0.95016982
77MP0001986_abnormal_taste_sensitivity0.94858530
78MP0001765_abnormal_ion_homeostasis0.94325141
79MP0002089_abnormal_postnatal_growth/wei0.93775406
80* MP0004130_abnormal_muscle_cell0.92132245
81MP0002734_abnormal_mechanical_nocicepti0.90905402
82MP0009046_muscle_twitch0.90898316
83MP0004484_altered_response_of0.90579664
84MP0000751_myopathy0.90366080
85MP0003950_abnormal_plasma_membrane0.90108602
86MP0005535_abnormal_body_temperature0.90000395
87* MP0002078_abnormal_glucose_homeostasis0.89366358
88MP0001970_abnormal_pain_threshold0.89269618
89MP0005636_abnormal_mineral_homeostasis0.88755762
90MP0000749_muscle_degeneration0.88471143
91MP0002653_abnormal_ependyma_morphology0.87323205
92MP0004924_abnormal_behavior0.87138092
93MP0005386_behavior/neurological_phenoty0.87138092
94MP0004133_heterotaxia0.86982478
95* MP0009642_abnormal_blood_homeostasis0.86493872
96MP0001486_abnormal_startle_reflex0.86008275
97MP0008469_abnormal_protein_level0.83332752
98MP0003137_abnormal_impulse_conducting0.81759466
99MP0005084_abnormal_gallbladder_morpholo0.81062256
100MP0002163_abnormal_gland_morphology0.80753582
101MP0001963_abnormal_hearing_physiology0.80212253
102MP0005376_homeostasis/metabolism_phenot0.79805737
103* MP0005334_abnormal_fat_pad0.78322882
104MP0004742_abnormal_vestibular_system0.77038475
105MP0005377_hearing/vestibular/ear_phenot0.76725783
106MP0003878_abnormal_ear_physiology0.76725783
107MP0002972_abnormal_cardiac_muscle0.76478686
108MP0001661_extended_life_span0.76468927
109MP0002102_abnormal_ear_morphology0.76355574
110MP0002735_abnormal_chemical_nociception0.76267639
111MP0006276_abnormal_autonomic_nervous0.75408020
112MP0005408_hypopigmentation0.73608494
113MP0005174_abnormal_tail_pigmentation0.72923101
114MP0002876_abnormal_thyroid_physiology0.72646186
115MP0005266_abnormal_metabolism0.72335881
116MP0006035_abnormal_mitochondrial_morpho0.72312264
117MP0002557_abnormal_social/conspecific_i0.72245267
118MP0009765_abnormal_xenobiotic_induced0.71331964
119MP0002938_white_spotting0.70761960
120MP0009780_abnormal_chondrocyte_physiolo0.70663906
121MP0003567_abnormal_fetal_cardiomyocyte0.69737270
122MP0002067_abnormal_sensory_capabilities0.69729886
123MP0002572_abnormal_emotion/affect_behav0.69334414
124MP0003690_abnormal_glial_cell0.68298326
125MP0003938_abnormal_ear_development0.67948317
126MP0005220_abnormal_exocrine_pancreas0.66877584
127MP0001756_abnormal_urination0.65105059
128MP0004270_analgesia0.64938087
129* MP0005448_abnormal_energy_balance0.57054621
130MP0003329_amyloid_beta_deposits0.57020598
131MP0000639_abnormal_adrenal_gland0.53376813
132MP0009115_abnormal_fat_cell0.52396476
133MP0002822_catalepsy0.51310059
134MP0009053_abnormal_anal_canal0.49865515
135MP0003724_increased_susceptibility_to0.49200812
136MP0002136_abnormal_kidney_physiology0.49011529
137MP0004185_abnormal_adipocyte_glucose0.49007713
138MP0003646_muscle_fatigue0.47229110
139MP0002970_abnormal_white_adipose0.46031233
140* MP0003953_abnormal_hormone_level0.45288529
141MP0005395_other_phenotype0.45248451
142MP0009384_cardiac_valve_regurgitation0.44374652
143MP0008874_decreased_physiological_sensi0.43211846
144MP0002928_abnormal_bile_duct0.41212026
145MP0003638_abnormal_response/metabolism_0.41115734
146MP0002796_impaired_skin_barrier0.40398004
147MP0005375_adipose_tissue_phenotype0.40348943
148MP0005464_abnormal_platelet_physiology0.39978722
149MP0008872_abnormal_physiological_respon0.39622918
150MP0004782_abnormal_surfactant_physiolog0.39334880
151MP0008873_increased_physiological_sensi0.39141513
152MP0004381_abnormal_hair_follicle0.37279614
153MP0004043_abnormal_pH_regulation0.36470734
154* MP0000230_abnormal_systemic_arterial0.36226244
155MP0005248_abnormal_Harderian_gland0.36187382
156MP0009672_abnormal_birth_weight0.35913721
157MP0002269_muscular_atrophy0.35861359
158MP0002168_other_aberrant_phenotype0.34854488
159MP0000579_abnormal_nail_morphology0.34583276
160MP0003718_maternal_effect0.33514683
161* MP0005330_cardiomyopathy0.33290537
162MP0003075_altered_response_to0.31869206
163MP0005166_decreased_susceptibility_to0.31371022
164MP0000249_abnormal_blood_vessel0.30955056
165MP0002090_abnormal_vision0.29583909
166MP0001881_abnormal_mammary_gland0.28210116
167MP0002060_abnormal_skin_morphology0.27253183
168MP0002332_abnormal_exercise_endurance0.26199748
169MP0006138_congestive_heart_failure0.25899220

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.91573239
2Intrahepatic cholestasis (HP:0001406)6.90616843
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.76085435
4Prolonged partial thromboplastin time (HP:0003645)6.11592326
5Xanthomatosis (HP:0000991)6.10114654
6Abnormality of monocarboxylic acid metabolism (HP:0010996)6.08428716
7Hypobetalipoproteinemia (HP:0003563)6.04012035
8Hyperlipoproteinemia (HP:0010980)5.28787818
9Complement deficiency (HP:0004431)4.99879416
10Hyperammonemia (HP:0001987)4.83488423
11Hypolipoproteinemia (HP:0010981)4.72472177
12Ketosis (HP:0001946)4.53207811
13Epidermoid cyst (HP:0200040)4.52813358
14Hyperglycinemia (HP:0002154)4.52220669
15Hyperglycinuria (HP:0003108)4.49915432
16Hypoglycemic coma (HP:0001325)4.43145413
17Joint hemorrhage (HP:0005261)4.42269816
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.34799475
19Abnormality of glycine metabolism (HP:0010895)4.31332174
20Abnormality of serine family amino acid metabolism (HP:0010894)4.31332174
21Hypoalphalipoproteinemia (HP:0003233)4.28150951
22Genetic anticipation (HP:0003743)4.20605607
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.19038989
24Abnormality of the common coagulation pathway (HP:0010990)4.17085121
25Abnormality of aspartate family amino acid metabolism (HP:0010899)4.00545298
26Abnormality of methionine metabolism (HP:0010901)3.95792176
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.92661506
28Abnormality of fatty-acid metabolism (HP:0004359)3.90557760
29Fat malabsorption (HP:0002630)3.88754537
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.67836417
31Abnormality of complement system (HP:0005339)3.59743967
32Conjugated hyperbilirubinemia (HP:0002908)3.57435671
33Hypercholesterolemia (HP:0003124)3.54585945
34Progressive cerebellar ataxia (HP:0002073)3.52575903
35Abnormality of the intrinsic pathway (HP:0010989)3.50404768
36Decreased circulating renin level (HP:0003351)3.49806137
37Ketoacidosis (HP:0001993)3.46237928
38Abnormality of pyrimidine metabolism (HP:0004353)3.39936473
39Hyperbilirubinemia (HP:0002904)3.23845003
40Confusion (HP:0001289)3.17427286
41Abnormality of serum amino acid levels (HP:0003112)3.17208567
42Calf muscle hypertrophy (HP:0008981)3.13982190
43Dicarboxylic aciduria (HP:0003215)3.12342399
44Abnormality of dicarboxylic acid metabolism (HP:0010995)3.12342399
45Muscle hypertrophy of the lower extremities (HP:0008968)3.11130589
46Metabolic alkalosis (HP:0200114)3.04174635
47Pancreatic cysts (HP:0001737)3.03719277
48Delayed CNS myelination (HP:0002188)3.03640206
49Abolished electroretinogram (ERG) (HP:0000550)3.02081760
50Pendular nystagmus (HP:0012043)2.99117822
51Abnormality of nucleobase metabolism (HP:0010932)2.95100890
52Metabolic acidosis (HP:0001942)2.94781020
53Decreased central vision (HP:0007663)2.91729357
54Congenital sensorineural hearing impairment (HP:0008527)2.90783556
55Skin nodule (HP:0200036)2.87746071
56Congenital stationary night blindness (HP:0007642)2.87238642
57Myocardial infarction (HP:0001658)2.86850389
58Steatorrhea (HP:0002570)2.82237824
59Lethargy (HP:0001254)2.80905166
60Hepatocellular carcinoma (HP:0001402)2.79443750
61True hermaphroditism (HP:0010459)2.77948360
62Pancreatic fibrosis (HP:0100732)2.77327218
63Keratoconus (HP:0000563)2.76717464
64Increased corneal curvature (HP:0100692)2.76717464
65Spontaneous abortion (HP:0005268)2.75088524
66Abnormality of purine metabolism (HP:0004352)2.72683099
67Cerebral edema (HP:0002181)2.72054044
68Agitation (HP:0000713)2.68178142
69Aplasia/Hypoplasia of the tibia (HP:0005772)2.66787195
70Myotonia (HP:0002486)2.64105521
71Hypochromic microcytic anemia (HP:0004840)2.63845457
72Hypoglycemic seizures (HP:0002173)2.61956681
73Acanthocytosis (HP:0001927)2.60232101
74Abnormality of the nasal septum (HP:0000419)2.59979796
75Abnormality of the renal cortex (HP:0011035)2.58002629
76Generalized aminoaciduria (HP:0002909)2.57964215
77Vascular calcification (HP:0004934)2.48556154
78Short 4th metacarpal (HP:0010044)2.48455706
79Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.48455706
80Muscle fiber inclusion bodies (HP:0100299)2.48137580
81Short femoral neck (HP:0100864)2.47011195
82Absent rod-and cone-mediated responses on ERG (HP:0007688)2.45942043
83Systemic lupus erythematosus (HP:0002725)2.45113812
84Abnormal gallbladder morphology (HP:0012437)2.44036745
85Gout (HP:0001997)2.43341372
86Cholelithiasis (HP:0001081)2.40609508
87Osteomalacia (HP:0002749)2.35032181
88Methylmalonic acidemia (HP:0002912)2.34689491
89Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.34319370
90Hyperventilation (HP:0002883)2.33750399
91Chorioretinal atrophy (HP:0000533)2.32796060
92Type 1 muscle fiber predominance (HP:0003803)2.32379784
93Cholecystitis (HP:0001082)2.31411068
94Abnormal gallbladder physiology (HP:0012438)2.31411068
95Short tibia (HP:0005736)2.31049610
96Nephronophthisis (HP:0000090)2.29943228
97Mesomelia (HP:0003027)2.29561586
98Nemaline bodies (HP:0003798)2.29247617
99Renal cortical cysts (HP:0000803)2.27599997
100Pigmentary retinal degeneration (HP:0001146)2.27347689
101Vomiting (HP:0002013)2.25508265
102Congenital, generalized hypertrichosis (HP:0004540)2.25500048
103Spastic diplegia (HP:0001264)2.25349497
104Absent phalangeal crease (HP:0006109)2.24966820
105Irritability (HP:0000737)2.24632981
106Syncope (HP:0001279)2.23945952
107Methylmalonic aciduria (HP:0012120)2.23865464
108Abnormal rod and cone electroretinograms (HP:0008323)2.23277827
109Hyperinsulinemic hypoglycemia (HP:0000825)2.22870771
110Neonatal onset (HP:0003623)2.22097215
111Hydroxyprolinuria (HP:0003080)2.21580166
112Abnormality of proline metabolism (HP:0010907)2.21580166
113Cardiovascular calcification (HP:0011915)2.21236133
114Abnormality of midbrain morphology (HP:0002418)2.21115464
115Molar tooth sign on MRI (HP:0002419)2.21115464
116Glomerulonephritis (HP:0000099)2.21044911
117Alkalosis (HP:0001948)2.20542144
118Mitral stenosis (HP:0001718)2.20519409
119Pancreatitis (HP:0001733)2.19125615
120Esophageal varix (HP:0002040)2.18105676
121Abnormality of the phalanges of the 2nd finger (HP:0009541)2.17834467
122Malnutrition (HP:0004395)2.17833656
123Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.14559725
124Sensorimotor neuropathy (HP:0007141)2.14443923
125Abnormality of renin-angiotensin system (HP:0000847)2.13299656
126Enlarged kidneys (HP:0000105)2.13256395
127Brushfield spots (HP:0001088)2.11310214
128Late onset (HP:0003584)2.11253422
129Symphalangism affecting the phalanges of the hand (HP:0009773)2.11139321
130Abnormality of the renal collecting system (HP:0004742)2.10306190
131Abnormality of the renal medulla (HP:0100957)2.08557422
132Visual hallucinations (HP:0002367)2.08366005
133Proximal tubulopathy (HP:0000114)2.07254332
134Goiter (HP:0000853)2.06188666
135Amyloidosis (HP:0011034)2.04473509
136Cystic liver disease (HP:0006706)2.03964601
137Myoglobinuria (HP:0002913)2.03701448
138Mesangial abnormality (HP:0001966)2.03489192
139Ventricular fibrillation (HP:0001663)2.03333247
140Recurrent gram-negative bacterial infections (HP:0005420)2.01222585
141Poikilocytosis (HP:0004447)2.00401483
142Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99730579
143Abnormality of alanine metabolism (HP:0010916)1.99730579
144Hyperalaninemia (HP:0003348)1.99730579
145Gingival bleeding (HP:0000225)1.99310137
146Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98934380
147Abnormality of the 4th metacarpal (HP:0010012)1.98299140
148Hemorrhage of the eye (HP:0011885)1.97868203
149Furrowed tongue (HP:0000221)1.97542546
150Abnormality of the gallbladder (HP:0005264)1.96525189
151Decreased subcutaneous fat (HP:0001002)1.96089139
152Cerebral palsy (HP:0100021)1.95508634
153Hyperglycemia (HP:0003074)1.94959481
154Hemiplegia (HP:0002301)1.93037101
155Gaze-evoked nystagmus (HP:0000640)1.92982841
156Chronic hepatic failure (HP:0100626)1.92588311
157Abnormal cartilage morphology (HP:0002763)1.92211570
158Clumsiness (HP:0002312)1.92176654
159Hypokalemia (HP:0002900)1.91856227
160Menorrhagia (HP:0000132)1.91797100
161Prolonged QT interval (HP:0001657)1.91734418
162Abnormality of binocular vision (HP:0011514)1.91507298
163Diplopia (HP:0000651)1.91507298
164Glycosuria (HP:0003076)1.90646911
165Abnormality of urine glucose concentration (HP:0011016)1.90646911
166Abnormal finger flexion creases (HP:0006143)1.90112342
167Nausea (HP:0002018)1.89892326
168Thrombophlebitis (HP:0004418)1.89217980
169Elevated hepatic transaminases (HP:0002910)1.88004643
170Tubular atrophy (HP:0000092)1.87569638
171Attenuation of retinal blood vessels (HP:0007843)1.87407527
172Abnormality of the calf musculature (HP:0001430)1.86535575
173Type II lissencephaly (HP:0007260)1.86425619
174Abnormality of potassium homeostasis (HP:0011042)1.86209263
175Radial bowing (HP:0002986)1.85646733
176Opisthotonus (HP:0002179)1.85446296
177Rickets (HP:0002748)1.84838176
178Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.84537717
179Conjunctival hamartoma (HP:0100780)1.84086294
180Increased purine levels (HP:0004368)1.82805287
181Hyperuricemia (HP:0002149)1.82805287
182Acute hepatic failure (HP:0006554)1.81918372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.14857294
2SIK14.35852814
3FGFR43.92203224
4ERN13.69997879
5INSRR3.27358715
6TLK13.06175259
7ADRBK22.92475035
8ERBB42.62163121
9TAOK32.57295090
10WNK42.55304127
11PKN22.35354282
12TRIB32.34867773
13MST1R2.09369368
14ACVR1B2.06314584
15MAP2K41.99925640
16BMPR1B1.99414583
17PRKD21.98309803
18LATS11.82824466
19MAPK111.77111953
20STK391.75734897
21FLT31.70949920
22PIK3CG1.68552372
23PDK31.52348207
24PDK41.52348207
25PRKAA21.51609174
26WNK31.48082291
27FRK1.46716939
28PINK11.46041873
29TYK21.43371622
30CAMK1D1.39383325
31NEK91.39148576
32MAPK131.38054102
33CASK1.37413184
34ABL21.36604337
35MAP3K71.26896502
36DAPK21.25735825
37PTK61.25257993
38FGFR21.22485103
39KDR1.22390820
40TIE11.19559823
41MAPKAPK31.19554992
42MUSK1.18848956
43STK38L1.13438589
44JAK21.11999695
45CAMKK21.09221785
46ADRBK11.09197672
47OXSR11.08717958
48NTRK31.08104294
49JAK11.04740831
50TXK0.98536490
51MAP2K30.98198095
52NLK0.94678231
53PRKAA10.93646473
54TBK10.91954848
55MAP4K20.91388853
56MAPKAPK50.90093354
57ERBB20.89395512
58MAPK120.87165785
59PRKCG0.86690740
60RIPK10.84716282
61MAP3K100.84608662
62MAP3K30.84264741
63PRKACG0.83638279
64MARK10.82588211
65SGK30.81768482
66NTRK20.80716137
67RPS6KA60.80526693
68MAP3K140.80148995
69PIK3CA0.79468806
70MET0.78877054
71PDK20.78292039
72PRKACA0.78180719
73CAMK10.78128714
74GRK70.77637357
75PRKCZ0.77231314
76CAMK1G0.76445451
77SGK10.75128537
78EPHA30.75054303
79EPHB10.74050800
80GRK60.71829653
81CDK60.71496559
82NUAK10.70095003
83PDPK10.69686102
84OBSCN0.69518576
85TGFBR20.67919134
86MAP3K40.67803077
87MYLK0.67576845
88CAMK2A0.67331669
89IRAK30.67285283
90DYRK20.67276404
91CAMK2G0.66996402
92SGK20.65763391
93PRKCE0.65266084
94GSK3A0.64832022
95STK110.64694940
96FGFR30.61423920
97RPS6KA20.59203140
98TYRO30.58098276
99MAP2K60.57918014
100WNK10.57552126
101MAP3K50.55039704
102MAPK70.55002740
103DYRK1B0.54795854
104CSK0.53827777
105PKN10.51338070
106LMTK20.50900459
107TRPM70.48979896
108PNCK0.48544288
109SGK2230.48511756
110SGK4940.48511756
111AKT30.47901188
112MAP2K10.47445400
113MAP3K110.47267334
114CSNK1A10.46699240
115PDK10.46675144
116GRK10.46614216
117DMPK0.46286013
118PRKCQ0.45941308
119IGF1R0.45905831
120STK160.45678704
121TGFBR10.45242079
122SIK20.44793859
123PRKG10.44447737
124RPS6KC10.43737106
125RPS6KL10.43737106
126PTK2B0.42470493
127* PRKCA0.42262295
128IKBKB0.41917006
129RET0.41851862
130MAPK150.41526056
131IKBKE0.41152403
132KIT0.41103648
133CAMK2D0.41082385
134MTOR0.39999872
135* MAPK40.39352809
136PTK20.38586648
137GRK50.38325746
138CDK40.38314125
139RPS6KA30.37925334
140CAMK40.37735017
141MAP3K60.37584673
142TTN0.37439063
143EPHB20.36882866
144PHKG10.36498096
145PHKG20.36498096
146PRKCH0.35853629
147PAK30.35520393
148RPS6KA50.34403799
149CSF1R0.33568567
150IRAK10.31402673
151PRKD10.31298562
152ICK0.31175868
153LATS20.28906079
154TAOK20.27903064
155IRAK20.27301039
156PDGFRA0.27182135

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.21861758
2Nitrogen metabolism_Homo sapiens_hsa009103.57663436
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.23508199
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18898264
5Arginine biosynthesis_Homo sapiens_hsa002202.88126717
6Fatty acid degradation_Homo sapiens_hsa000712.86715522
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.74388758
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71651303
9Tryptophan metabolism_Homo sapiens_hsa003802.67476394
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.67143707
11Complement and coagulation cascades_Homo sapiens_hsa046102.53319378
12Propanoate metabolism_Homo sapiens_hsa006402.40529163
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.35492601
14Butanoate metabolism_Homo sapiens_hsa006502.29439696
15Fatty acid metabolism_Homo sapiens_hsa012122.18367138
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16515938
17Peroxisome_Homo sapiens_hsa041462.11684699
18* PPAR signaling pathway_Homo sapiens_hsa033202.02648554
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00114861
20beta-Alanine metabolism_Homo sapiens_hsa004101.83062794
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.82644423
22Chemical carcinogenesis_Homo sapiens_hsa052041.79872859
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.78364145
24Histidine metabolism_Homo sapiens_hsa003401.78346384
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.77013759
26Caffeine metabolism_Homo sapiens_hsa002321.67963972
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67504958
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65076568
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.63987487
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62202348
31Retinol metabolism_Homo sapiens_hsa008301.61712296
32Staphylococcus aureus infection_Homo sapiens_hsa051501.59306209
33Pyruvate metabolism_Homo sapiens_hsa006201.57154116
34Fatty acid elongation_Homo sapiens_hsa000621.56353594
35Cardiac muscle contraction_Homo sapiens_hsa042601.55611754
36Phenylalanine metabolism_Homo sapiens_hsa003601.50293757
37Bile secretion_Homo sapiens_hsa049761.46913784
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44055887
39Selenocompound metabolism_Homo sapiens_hsa004501.42608491
40Phototransduction_Homo sapiens_hsa047441.37166883
41Tyrosine metabolism_Homo sapiens_hsa003501.35557484
42Carbon metabolism_Homo sapiens_hsa012001.35093054
43Starch and sucrose metabolism_Homo sapiens_hsa005001.34037481
44Sulfur metabolism_Homo sapiens_hsa009201.29437815
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29150735
46Nicotine addiction_Homo sapiens_hsa050331.24343644
47Fat digestion and absorption_Homo sapiens_hsa049751.21829416
48ABC transporters_Homo sapiens_hsa020101.20883285
49Biosynthesis of amino acids_Homo sapiens_hsa012301.19108061
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.18227487
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17074467
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14905996
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12450811
54Folate biosynthesis_Homo sapiens_hsa007901.06952273
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06506205
56Serotonergic synapse_Homo sapiens_hsa047261.02535086
57Steroid biosynthesis_Homo sapiens_hsa001001.01371671
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93982320
59Insulin secretion_Homo sapiens_hsa049110.93840948
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93271440
61Morphine addiction_Homo sapiens_hsa050320.92641153
62Arginine and proline metabolism_Homo sapiens_hsa003300.92520745
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92507211
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.92010454
65Lysine degradation_Homo sapiens_hsa003100.91210936
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89693986
67Dilated cardiomyopathy_Homo sapiens_hsa054140.89081127
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.87050497
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86825299
70Vitamin digestion and absorption_Homo sapiens_hsa049770.86270105
71Calcium signaling pathway_Homo sapiens_hsa040200.84242291
72Vitamin B6 metabolism_Homo sapiens_hsa007500.84026021
73Ether lipid metabolism_Homo sapiens_hsa005650.83605086
74Sulfur relay system_Homo sapiens_hsa041220.82419292
75Fatty acid biosynthesis_Homo sapiens_hsa000610.81876871
76Glutamatergic synapse_Homo sapiens_hsa047240.81232714
77Glycerolipid metabolism_Homo sapiens_hsa005610.78762341
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78421033
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.72506804
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71285219
81GABAergic synapse_Homo sapiens_hsa047270.70820042
82Circadian entrainment_Homo sapiens_hsa047130.69848294
83Taste transduction_Homo sapiens_hsa047420.68523240
84Renin secretion_Homo sapiens_hsa049240.66869204
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66568344
86Mineral absorption_Homo sapiens_hsa049780.64596369
87Glutathione metabolism_Homo sapiens_hsa004800.60888482
88Alzheimers disease_Homo sapiens_hsa050100.59215276
89Pentose phosphate pathway_Homo sapiens_hsa000300.58872769
90One carbon pool by folate_Homo sapiens_hsa006700.57588594
91Cholinergic synapse_Homo sapiens_hsa047250.56960360
92Olfactory transduction_Homo sapiens_hsa047400.52734866
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50506904
94Metabolic pathways_Homo sapiens_hsa011000.46944641
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.43779699
96Cocaine addiction_Homo sapiens_hsa050300.43566011
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43327350
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40806779
99Oxytocin signaling pathway_Homo sapiens_hsa049210.40063698
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38823812
101Melanoma_Homo sapiens_hsa052180.38245049
102Dorso-ventral axis formation_Homo sapiens_hsa043200.36373654
103Dopaminergic synapse_Homo sapiens_hsa047280.33000911
104Galactose metabolism_Homo sapiens_hsa000520.28580360
105* Adipocytokine signaling pathway_Homo sapiens_hsa049200.27716109
106* Insulin resistance_Homo sapiens_hsa049310.27696155
107Fructose and mannose metabolism_Homo sapiens_hsa000510.27322827
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27092592
109Prion diseases_Homo sapiens_hsa050200.26018782
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.19990428
111Linoleic acid metabolism_Homo sapiens_hsa005910.18200827
112* Glucagon signaling pathway_Homo sapiens_hsa049220.14499387
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14042409
114AMPK signaling pathway_Homo sapiens_hsa041520.13933315
115* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09328500
116Protein digestion and absorption_Homo sapiens_hsa04974-0.2411979
117Parkinsons disease_Homo sapiens_hsa05012-0.2410488
118Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2293996
119Amoebiasis_Homo sapiens_hsa05146-0.2290590
120Type II diabetes mellitus_Homo sapiens_hsa04930-0.2158790
121Oxidative phosphorylation_Homo sapiens_hsa00190-0.2144811
122Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2053941
123Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2021758
124African trypanosomiasis_Homo sapiens_hsa05143-0.1909460
125Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1821126
126Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1726780
127Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1682768
128Regulation of autophagy_Homo sapiens_hsa04140-0.1621401
129Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1584074
130Renin-angiotensin system_Homo sapiens_hsa04614-0.1521910
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1512961
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1381192
133Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1233514
134Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0479534
135Insulin signaling pathway_Homo sapiens_hsa04910-0.0037258

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