PPARD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)3.96980827
2bundle of His cell to Purkinje myocyte communication (GO:0086069)3.90069703
3positive regulation of p38MAPK cascade (GO:1900745)3.76064610
4regulation of p38MAPK cascade (GO:1900744)3.70111003
5regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.67205857
6protein localization to endosome (GO:0036010)3.66868964
7positive regulation of histone deacetylation (GO:0031065)3.62814285
8epithelial cell-cell adhesion (GO:0090136)3.61821665
9cell-substrate junction assembly (GO:0007044)3.59650303
10regulation of cholesterol homeostasis (GO:2000188)3.55308351
11low-density lipoprotein particle clearance (GO:0034383)3.55116830
12regulation of integrin activation (GO:0033623)3.50553303
13apoptotic process involved in morphogenesis (GO:0060561)3.50508845
14regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.49222270
15intestinal absorption (GO:0050892)3.39716922
16plasma membrane repair (GO:0001778)3.37670382
17cytoskeletal anchoring at plasma membrane (GO:0007016)3.34890666
18intestinal cholesterol absorption (GO:0030299)3.30274507
19trophectodermal cell differentiation (GO:0001829)3.29045680
20maternal placenta development (GO:0001893)3.20716349
21apoptotic cell clearance (GO:0043277)3.20489705
22skin morphogenesis (GO:0043589)3.17596192
23barbed-end actin filament capping (GO:0051016)3.15090018
24negative regulation of cell size (GO:0045792)3.13865530
25desmosome organization (GO:0002934)3.07509374
26positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.07262255
27regulation of vitamin D biosynthetic process (GO:0060556)3.05796651
28negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.04919850
29sarcomere organization (GO:0045214)3.01528009
30adherens junction assembly (GO:0034333)2.99162889
31keratinization (GO:0031424)2.95614957
32mannose metabolic process (GO:0006013)2.94364581
33negative regulation of fatty acid transport (GO:2000192)2.93417009
34branching involved in labyrinthine layer morphogenesis (GO:0060670)2.90532365
35cell-substrate adherens junction assembly (GO:0007045)2.87915151
36focal adhesion assembly (GO:0048041)2.87915151
37NIK/NF-kappaB signaling (GO:0038061)2.87752144
38lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87566742
39regulation of tight junction assembly (GO:2000810)2.84768195
40regulation of hippo signaling (GO:0035330)2.83644295
41intestinal epithelial cell development (GO:0060576)2.82831398
42stress fiber assembly (GO:0043149)2.82820642
43response to laminar fluid shear stress (GO:0034616)2.82338091
44response to peptidoglycan (GO:0032494)2.81950045
45macrophage activation involved in immune response (GO:0002281)2.80354146
46regulation of early endosome to late endosome transport (GO:2000641)2.80271193
47negative regulation of erythrocyte differentiation (GO:0045647)2.80126510
48germinal center formation (GO:0002467)2.78367925
49regulation of T-helper 2 cell differentiation (GO:0045628)2.74469901
50negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.74027025
51growth hormone receptor signaling pathway (GO:0060396)2.69049944
52regulation of cholesterol storage (GO:0010885)2.68696348
53negative regulation of interleukin-12 production (GO:0032695)2.67569049
54negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.66826820
55endodermal cell differentiation (GO:0035987)2.66533198
56heterochromatin organization (GO:0070828)2.64663730
57regulation of water loss via skin (GO:0033561)2.61951401
58activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.58000724
59protein hydroxylation (GO:0018126)2.57381854
60regulation of extracellular matrix disassembly (GO:0010715)2.56290580
61atrioventricular valve morphogenesis (GO:0003181)2.54031764
62peptidyl-proline hydroxylation (GO:0019511)2.52147754
63NLS-bearing protein import into nucleus (GO:0006607)2.51008783
64regulation of vitamin metabolic process (GO:0030656)2.49046037
65positive regulation of protein deacetylation (GO:0090312)2.48781414
66intracellular estrogen receptor signaling pathway (GO:0030520)2.48462167
67basement membrane organization (GO:0071711)2.48171379
68positive regulation of Cdc42 GTPase activity (GO:0043089)2.48164125
69positive regulation of extracellular matrix organization (GO:1903055)2.47661627
70positive regulation of receptor recycling (GO:0001921)2.47576839
71response to muramyl dipeptide (GO:0032495)2.47237446
72protein heterotrimerization (GO:0070208)2.47073215
73apoptotic process involved in development (GO:1902742)2.46271206
74glycosphingolipid catabolic process (GO:0046479)2.44838162
754-hydroxyproline metabolic process (GO:0019471)2.44052998
76endocytic recycling (GO:0032456)2.44008256
77pinocytosis (GO:0006907)2.43733237
78positive regulation of nuclease activity (GO:0032075)2.43012710
79positive regulation of chemokine biosynthetic process (GO:0045080)2.42684099
80positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.40815323
81establishment of skin barrier (GO:0061436)2.39691776
82regulation of NFAT protein import into nucleus (GO:0051532)2.39411555
83positive regulation of cellular amide metabolic process (GO:0034250)2.38714423
84adhesion of symbiont to host (GO:0044406)2.38643505
85detection of other organism (GO:0098543)2.38216937
86intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.37373731
87modulation by symbiont of host defense response (GO:0052031)2.37188819
88modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.37188819
89modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.37188819
90positive regulation by organism of defense response of other organism involved in symbiotic interact2.37188819
91modulation by symbiont of host immune response (GO:0052553)2.37188819
92positive regulation by symbiont of host defense response (GO:0052509)2.37188819
93vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.37167395
94detection of bacterium (GO:0016045)2.37140273
95cellular response to nutrient (GO:0031670)2.36899341
96virion attachment to host cell (GO:0019062)2.36622010
97adhesion of symbiont to host cell (GO:0044650)2.36622010
98endothelial cell chemotaxis (GO:0035767)2.36005366
99activation of MAPKKK activity (GO:0000185)2.35734040
100cell adhesion mediated by integrin (GO:0033627)2.35147733
101cellular response to growth hormone stimulus (GO:0071378)2.34958098
102positive regulation of protein dephosphorylation (GO:0035307)2.33735439
103receptor catabolic process (GO:0032801)2.32185399
104signal complex assembly (GO:0007172)2.31751753
105cellular response to thyroid hormone stimulus (GO:0097067)2.31159012
106blood vessel endothelial cell migration (GO:0043534)2.30992387
107skeletal muscle adaptation (GO:0043501)2.30249591
108semaphorin-plexin signaling pathway (GO:0071526)2.30127462
109polarized epithelial cell differentiation (GO:0030859)2.30075048
110negative regulation of heart growth (GO:0061117)2.29685422
111negative regulation of cardiac muscle tissue growth (GO:0055022)2.29685422
112negative regulation of nucleotide catabolic process (GO:0030812)2.29482150
113regulation of fatty acid beta-oxidation (GO:0031998)2.28428161
114positive regulation of Rho protein signal transduction (GO:0035025)2.28259755
115modulation by symbiont of host cellular process (GO:0044068)2.27914775
116cardiac myofibril assembly (GO:0055003)2.25663971
117negative regulation of potassium ion transmembrane transport (GO:1901380)2.25019145
118negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.24886301
119negative regulation of cell killing (GO:0031342)2.24886301
120L-alpha-amino acid transmembrane transport (GO:1902475)2.24810394
121epithelial structure maintenance (GO:0010669)2.23743837
122wound healing, spreading of epidermal cells (GO:0035313)2.23186309
123regulation of membrane protein ectodomain proteolysis (GO:0051043)2.23163414
124striated muscle atrophy (GO:0014891)2.22794949
125substrate-dependent cell migration (GO:0006929)2.22664260
126positive regulation of triglyceride biosynthetic process (GO:0010867)2.20999086
127ventricular cardiac muscle cell action potential (GO:0086005)2.20901237
128regulation of podosome assembly (GO:0071801)2.20294820
129hypotonic response (GO:0006971)2.20195625
130response to fluid shear stress (GO:0034405)2.19658376
131hippo signaling (GO:0035329)2.19326414
132ectoderm development (GO:0007398)2.19291564
133actin filament bundle organization (GO:0061572)2.19287594
134actin filament bundle assembly (GO:0051017)2.19287594
135labyrinthine layer blood vessel development (GO:0060716)2.18458624
136myeloid dendritic cell differentiation (GO:0043011)2.18221297
137response to progesterone (GO:0032570)2.17979340
138positive regulation of lipid storage (GO:0010884)2.17977848
139carnitine shuttle (GO:0006853)2.17571398
140negative regulation of lipid transport (GO:0032369)2.17334225
141establishment of endothelial barrier (GO:0061028)2.17197868
142regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.17044305
143epithelial cell differentiation involved in prostate gland development (GO:0060742)2.16290575
144sodium ion export (GO:0071436)2.15458465
145glycolipid catabolic process (GO:0019377)2.15450487
146cortical actin cytoskeleton organization (GO:0030866)2.15268435
147regulation of nuclease activity (GO:0032069)2.15121802
148embryonic placenta development (GO:0001892)2.15094465
149hepatocyte apoptotic process (GO:0097284)2.15085680
150cell migration involved in sprouting angiogenesis (GO:0002042)2.14938588
151positive regulation of blood vessel endothelial cell migration (GO:0043536)2.14526898
152regulation of leukocyte degranulation (GO:0043300)2.14253977
153detection of external biotic stimulus (GO:0098581)2.13977307
154cell-cell junction maintenance (GO:0045217)2.12690001
155regulation of type I interferon-mediated signaling pathway (GO:0060338)2.11724984
156positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.11560096
157regulation of macrophage chemotaxis (GO:0010758)2.09656550
158Golgi transport vesicle coating (GO:0048200)2.08757041
159COPI coating of Golgi vesicle (GO:0048205)2.08757041
160regulation of mononuclear cell migration (GO:0071675)2.08577311
161regulation of chemokine biosynthetic process (GO:0045073)2.08007212
162surfactant homeostasis (GO:0043129)2.07703087
163* decidualization (GO:0046697)2.07565326
164regulation of apoptotic process involved in morphogenesis (GO:1902337)2.06158944
165response to acidic pH (GO:0010447)2.06027083
166regulation of extracellular matrix organization (GO:1903053)2.05390109
167positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.05040993
168response to magnesium ion (GO:0032026)2.03706331
169detection of molecule of bacterial origin (GO:0032490)2.02430293
170regulation of transforming growth factor beta1 production (GO:0032908)2.02229649
171regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.01877563
172response to manganese ion (GO:0010042)2.01622656
173negative regulation of cytokine production involved in immune response (GO:0002719)2.01430952

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.24243890
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.37914612
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.50437851
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.34624452
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.29518086
6MYC_22102868_ChIP-Seq_BL_Human2.25460649
7ELK3_25401928_ChIP-Seq_HUVEC_Human2.23970750
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.16134083
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.14705652
10RACK7_27058665_Chip-Seq_MCF-7_Human2.11797706
11ZNF263_19887448_ChIP-Seq_K562_Human2.07467583
12KDM2B_26808549_Chip-Seq_DND41_Human2.07176397
13KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.01534183
14LXR_22292898_ChIP-Seq_THP-1_Human1.98515179
15VDR_21846776_ChIP-Seq_THP-1_Human1.98219253
16TCF7_22412390_ChIP-Seq_EML_Mouse1.97709267
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.97010352
18HIF1A_21447827_ChIP-Seq_MCF-7_Human1.96253095
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.92091511
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.89491539
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89053686
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.88901580
23ATF3_27146783_Chip-Seq_COLON_Human1.84989739
24CLOCK_20551151_ChIP-Seq_293T_Human1.73130076
25* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71165270
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70259831
27CDX2_20551321_ChIP-Seq_CACO-2_Human1.70182288
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69782806
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.65995009
30KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.65732329
31P300_27058665_Chip-Seq_ZR-75-30cells_Human1.65250218
32RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.63244210
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62118392
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59511379
35KDM2B_26808549_Chip-Seq_K562_Human1.59319244
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57122607
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.56366813
38GATA6_25053715_ChIP-Seq_YYC3_Human1.54615486
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53427538
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52429629
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.51390281
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49664300
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47410766
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.47274665
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46965575
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45684303
47ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.45585312
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.45553755
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.44358281
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.43828680
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43439812
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43272450
53IRF8_27001747_Chip-Seq_BMDM_Mouse1.41928296
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41817974
55* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.40278803
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.39009357
57CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38531296
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36505350
59MAF_26560356_Chip-Seq_TH1_Human1.34042799
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32546910
61* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32054178
62* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31207774
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30956376
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.30655485
65CREB1_26743006_Chip-Seq_LNCaP_Human1.30241661
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30188461
67* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29775781
68* NCOR1_26117541_ChIP-Seq_K562_Human1.29344412
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29253801
70NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27098787
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26288468
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26260656
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25983018
74ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24412594
75* GATA2_21666600_ChIP-Seq_HMVEC_Human1.23869657
76VDR_24763502_ChIP-Seq_THP-1_Human1.23136868
77UTX_26944678_Chip-Seq_JUKART_Human1.23083854
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22477079
79* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22432004
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22113090
81* RXR_22158963_ChIP-Seq_LIVER_Mouse1.22043425
82ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21063864
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.20421835
84* TBX20_22080862_ChIP-Seq_HEART_Mouse1.20326437
85* TBX20_22328084_ChIP-Seq_HEART_Mouse1.20326437
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16768033
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16370820
88* LXR_22158963_ChIP-Seq_LIVER_Mouse1.16060596
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15754432
90TP53_22127205_ChIP-Seq_IMR90_Human1.14969167
91SMC4_20622854_ChIP-Seq_HELA_Human1.14327213
92NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14065013
93GATA1_19941826_ChIP-Seq_K562_Human1.13366905
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13118938
95* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12166843
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.11983686
97GATA1_19941827_ChIP-Seq_MEL_Mouse1.11884503
98* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11708393
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.11662843
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10606504
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09737966
102P68_20966046_ChIP-Seq_HELA_Human1.09262310
103CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08937872
104* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08794386
105SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08729015
106IRF8_21731497_ChIP-ChIP_J774_Mouse1.08026902
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07795436
108FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07394683
109NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06583036
110* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05356283
111SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04275078
112KLF5_25053715_ChIP-Seq_YYC3_Human1.03478638
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03102469
114* SPI1_23127762_ChIP-Seq_K562_Human1.02969345
115GATA4_25053715_ChIP-Seq_YYC3_Human1.02663954
116SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01957494
117SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01957494
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01400472
119SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00775071
120UBF1/2_26484160_Chip-Seq_HMECs_Human1.00340054
121SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00068476
122TET1_21451524_ChIP-Seq_MESCs_Mouse0.99965141
123FOXM1_23109430_ChIP-Seq_U2OS_Human0.99600525
124* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99329652
125* TP63_22573176_ChIP-Seq_HFKS_Human0.99224338
126STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98001165
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97063016
128SA1_27219007_Chip-Seq_ERYTHROID_Human0.96389093

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003705_abnormal_hypodermis_morpholog3.46255405
2MP0005451_abnormal_body_composition2.74887131
3MP0010234_abnormal_vibrissa_follicle2.67979708
4MP0003300_gastrointestinal_ulcer2.60948782
5MP0005076_abnormal_cell_differentiation2.55763035
6MP0003566_abnormal_cell_adhesion2.50590435
7MP0003172_abnormal_lysosome_physiology2.32449221
8MP0004264_abnormal_extraembryonic_tissu2.28052643
9MP0008438_abnormal_cutaneous_collagen2.24296442
10MP0002877_abnormal_melanocyte_morpholog2.16605975
11MP0009840_abnormal_foam_cell2.10279399
12MP0009278_abnormal_bone_marrow2.00560402
13MP0004185_abnormal_adipocyte_glucose2.00536458
14MP0001849_ear_inflammation1.93826638
15MP0001958_emphysema1.89969713
16* MP0010352_gastrointestinal_tract_polyps1.87829279
17MP0003075_altered_response_to1.82638040
18MP0001533_abnormal_skeleton_physiology1.82440020
19MP0005275_abnormal_skin_tensile1.81807281
20MP0006082_CNS_inflammation1.80410482
21MP0002998_abnormal_bone_remodeling1.76370537
22MP0003303_peritoneal_inflammation1.75981002
23MP0004084_abnormal_cardiac_muscle1.70554656
24MP0002148_abnormal_hypersensitivity_rea1.69106274
25MP0008260_abnormal_autophagy1.67731915
26MP0002796_impaired_skin_barrier1.67053029
27MP0000750_abnormal_muscle_regeneration1.64421213
28* MP0005023_abnormal_wound_healing1.63639339
29MP0002419_abnormal_innate_immunity1.63106610
30MP0003045_fibrosis1.62067116
31MP0003724_increased_susceptibility_to1.59825479
32MP0005666_abnormal_adipose_tissue1.55258244
33MP0000604_amyloidosis1.54997175
34MP0004087_abnormal_muscle_fiber1.53539747
35MP0000733_abnormal_muscle_development1.52791532
36MP0003329_amyloid_beta_deposits1.51984591
37MP0002837_dystrophic_cardiac_calcinosis1.50485556
38MP0005360_urolithiasis1.50384495
39MP0005623_abnormal_meninges_morphology1.48734824
40MP0001790_abnormal_immune_system1.46331317
41MP0005387_immune_system_phenotype1.46331317
42MP0008961_abnormal_basal_metabolism1.45835355
43* MP0003453_abnormal_keratinocyte_physiol1.42932146
44MP0009785_altered_susceptibility_to1.41593213
45MP0005409_darkened_coat_color1.41328131
46MP0000751_myopathy1.41216747
47MP0010630_abnormal_cardiac_muscle1.40977745
48MP0001666_abnormal_nutrient_absorption1.40641937
49MP0004272_abnormal_basement_membrane1.39121416
50MP0005000_abnormal_immune_tolerance1.38195223
51MP0005025_abnormal_response_to1.35689528
52MP0005166_decreased_susceptibility_to1.31771518
53MP0003091_abnormal_cell_migration1.29087885
54MP0003866_abnormal_defecation1.27932664
55MP0008004_abnormal_stomach_pH1.27347480
56MP0004510_myositis1.26640401
57* MP0004947_skin_inflammation1.23163862
58MP0003283_abnormal_digestive_organ1.22785000
59MP0005501_abnormal_skin_physiology1.21850125
60MP0000685_abnormal_immune_system1.21458513
61MP0005330_cardiomyopathy1.21359700
62MP0005257_abnormal_intraocular_pressure1.20076357
63MP0006054_spinal_hemorrhage1.18812575
64MP0000749_muscle_degeneration1.18176133
65MP0001853_heart_inflammation1.16938955
66MP0002933_joint_inflammation1.16299584
67MP0003646_muscle_fatigue1.16243713
68* MP0002060_abnormal_skin_morphology1.16187945
69MP0009333_abnormal_splenocyte_physiolog1.14893738
70MP0010307_abnormal_tumor_latency1.14413321
71MP0010155_abnormal_intestine_physiology1.13895306
72MP0005670_abnormal_white_adipose1.12911959
73MP0005164_abnormal_response_to1.12690373
74MP0002269_muscular_atrophy1.12613934
75MP0004233_abnormal_muscle_weight1.12419210
76MP0005390_skeleton_phenotype1.12068526
77MP0000678_abnormal_parathyroid_gland1.12058737
78MP0009053_abnormal_anal_canal1.10894474
79MP0003191_abnormal_cellular_cholesterol1.10844782
80* MP0005375_adipose_tissue_phenotype1.10708789
81MP0003690_abnormal_glial_cell1.09671547
82MP0009764_decreased_sensitivity_to1.08377901
83MP0004130_abnormal_muscle_cell1.07749582
84MP0002452_abnormal_antigen_presenting1.07266577
85MP0001542_abnormal_bone_strength1.06654462
86MP0010030_abnormal_orbit_morphology1.03612089
87MP0003950_abnormal_plasma_membrane1.03228045
88MP0003279_aneurysm1.02410117
89MP0005397_hematopoietic_system_phenotyp1.02172271
90MP0001545_abnormal_hematopoietic_system1.02172271
91MP0000490_abnormal_crypts_of1.02107984
92MP0000579_abnormal_nail_morphology1.01570401
93MP0002723_abnormal_immune_serum1.00338726
94MP0003448_altered_tumor_morphology0.98605901
95MP0008775_abnormal_heart_ventricle0.97686001
96MP0005464_abnormal_platelet_physiology0.97651266
97* MP0000477_abnormal_intestine_morphology0.97391477
98MP0003252_abnormal_bile_duct0.97356388
99MP0000759_abnormal_skeletal_muscle0.97158956
100MP0002925_abnormal_cardiovascular_devel0.97060052
101MP0001835_abnormal_antigen_presentation0.96591373
102MP0002106_abnormal_muscle_physiology0.96374960
103MP0005167_abnormal_blood-brain_barrier0.95877769
104* MP0002086_abnormal_extraembryonic_tissu0.95396034
105MP0005595_abnormal_vascular_smooth0.94063995
106* MP0001216_abnormal_epidermal_layer0.91614381
107MP0002139_abnormal_hepatobiliary_system0.91541926
108MP0003436_decreased_susceptibility_to0.90981943
109MP0002332_abnormal_exercise_endurance0.90825453
110MP0005165_increased_susceptibility_to0.89623458
111MP0002254_reproductive_system_inflammat0.89275413
112MP0003828_pulmonary_edema0.89122137
113MP0003221_abnormal_cardiomyocyte_apopto0.89006443
114MP0001845_abnormal_inflammatory_respons0.88704615
115MP0000249_abnormal_blood_vessel0.88666426
116MP0005385_cardiovascular_system_phenoty0.88146145
117MP0001544_abnormal_cardiovascular_syste0.88146145
118MP0001800_abnormal_humoral_immune0.86959145
119MP0002405_respiratory_system_inflammati0.86760047
120MP0001851_eye_inflammation0.86229487
121MP0000467_abnormal_esophagus_morphology0.85285984
122MP0000343_altered_response_to0.85280217
123MP0000266_abnormal_heart_morphology0.85201673
124MP0003795_abnormal_bone_structure0.85095359
125MP0000747_muscle_weakness0.84695121
126MP0005058_abnormal_lysosome_morphology0.84431766
127MP0002972_abnormal_cardiac_muscle0.83450022
128MP0004036_abnormal_muscle_relaxation0.83386625
129MP0003879_abnormal_hair_cell0.83368491
130* MP0003984_embryonic_growth_retardation0.83211931
131MP0001819_abnormal_immune_cell0.82636460
132MP0008874_decreased_physiological_sensi0.82527095
133* MP0002088_abnormal_embryonic_growth/wei0.82499611
134MP0008469_abnormal_protein_level0.82493195
135* MP0000920_abnormal_myelination0.82458828
136MP0002420_abnormal_adaptive_immunity0.81694729
137MP0002089_abnormal_postnatal_growth/wei0.81223460
138* MP0004197_abnormal_fetal_growth/weight/0.79737897
139MP0003567_abnormal_fetal_cardiomyocyte0.78609710
140MP0000462_abnormal_digestive_system0.77810588
141MP0002896_abnormal_bone_mineralization0.77490489
142MP0005377_hearing/vestibular/ear_phenot0.76760563
143MP0003878_abnormal_ear_physiology0.76760563
144MP0000858_altered_metastatic_potential0.76547303
145MP0001348_abnormal_lacrimal_gland0.76491327
146MP0001873_stomach_inflammation0.76314892
147MP0004858_abnormal_nervous_system0.76175434
148MP0006138_congestive_heart_failure0.75764490
149* MP0009931_abnormal_skin_appearance0.74882623
150MP0000767_abnormal_smooth_muscle0.74116790
151MP0001243_abnormal_dermal_layer0.72981686
152MP0001614_abnormal_blood_vessel0.72924084
153MP0005369_muscle_phenotype0.72824489

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)4.50678691
2Increased connective tissue (HP:0009025)3.86440167
3Abnormality of glycolipid metabolism (HP:0010969)3.78321745
4Abnormality of liposaccharide metabolism (HP:0010968)3.78321745
5Abnormality of glycosphingolipid metabolism (HP:0004343)3.78321745
6Cerebral aneurysm (HP:0004944)3.44149051
7Protrusio acetabuli (HP:0003179)3.34361189
8Ventricular tachycardia (HP:0004756)3.13536381
9Premature rupture of membranes (HP:0001788)3.12154407
10Dysostosis multiplex (HP:0000943)3.03684967
11Mildly elevated creatine phosphokinase (HP:0008180)3.01740920
12Neurofibrillary tangles (HP:0002185)2.95212515
13Atrophic scars (HP:0001075)2.93392635
14Obstructive sleep apnea (HP:0002870)2.92288510
15Increased cerebral lipofuscin (HP:0011813)2.92248468
16Shallow orbits (HP:0000586)2.87064535
17Hyporeflexia of lower limbs (HP:0002600)2.86060795
18Abnormality of nail color (HP:0100643)2.82275435
19Systemic lupus erythematosus (HP:0002725)2.76291115
20Flat acetabular roof (HP:0003180)2.73030446
21Muscle fiber splitting (HP:0003555)2.72642567
22Eczematoid dermatitis (HP:0000976)2.70885072
23Exercise-induced muscle cramps (HP:0003710)2.62657028
24Milia (HP:0001056)2.61210685
25Difficulty running (HP:0009046)2.59897629
26Loss of speech (HP:0002371)2.59581042
27Abnormality of polysaccharide metabolism (HP:0011012)2.57826274
28Abnormality of glycosaminoglycan metabolism (HP:0004371)2.57826274
29Abnormality of mucopolysaccharide metabolism (HP:0011020)2.57826274
30Difficulty climbing stairs (HP:0003551)2.57739654
31Upper limb amyotrophy (HP:0009129)2.54618172
32Distal upper limb amyotrophy (HP:0007149)2.54618172
33Ankle contracture (HP:0006466)2.52039154
34Polycythemia (HP:0001901)2.49445119
35Type 1 muscle fiber predominance (HP:0003803)2.49271811
36Vertebral compression fractures (HP:0002953)2.49252567
37Mucopolysacchariduria (HP:0008155)2.49077656
38Urinary glycosaminoglycan excretion (HP:0003541)2.49077656
39Aneurysm (HP:0002617)2.48884133
40Increased neuronal autofluorescent lipopigment (HP:0002074)2.47199542
41Abnormality of macrophages (HP:0004311)2.46394338
42Ulnar bowing (HP:0003031)2.45806740
43Cervical subluxation (HP:0003308)2.44482834
44Genu recurvatum (HP:0002816)2.42184915
45Fragile skin (HP:0001030)2.41234715
46Cerebral inclusion bodies (HP:0100314)2.39738262
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.39433148
48Asymmetric septal hypertrophy (HP:0001670)2.36836344
49Broad metatarsal (HP:0001783)2.36635336
50Bundle branch block (HP:0011710)2.35965872
51Peritonitis (HP:0002586)2.34346792
52Mitral valve prolapse (HP:0001634)2.31002491
53Sudden death (HP:0001699)2.30099906
54Nuclear cataract (HP:0100018)2.28102383
55Thick nail (HP:0001805)2.27551191
56Broad face (HP:0000283)2.24667723
57Hand muscle atrophy (HP:0009130)2.24626056
58Spondylolisthesis (HP:0003302)2.24511332
59Autoimmune thrombocytopenia (HP:0001973)2.23873596
60Vacuolated lymphocytes (HP:0001922)2.20538595
61Thin bony cortex (HP:0002753)2.19663868
62Alopecia of scalp (HP:0002293)2.13952547
63Supranuclear gaze palsy (HP:0000605)2.13781708
64Hypoplastic ischia (HP:0003175)2.12215493
65Ileus (HP:0002595)2.11289756
66Hyperacusis (HP:0010780)2.08616918
67Aortic aneurysm (HP:0004942)2.07819850
68Interstitial pulmonary disease (HP:0006530)2.07364496
69Achilles tendon contracture (HP:0001771)2.07186565
70Lower limb amyotrophy (HP:0007210)2.05320584
71Distal lower limb amyotrophy (HP:0008944)2.04268276
72Follicular hyperkeratosis (HP:0007502)2.03572490
73Segmental peripheral demyelination/remyelination (HP:0003481)2.03539994
74Rectal prolapse (HP:0002035)2.01608056
75Lymphangioma (HP:0100764)1.99654564
76Aortic dissection (HP:0002647)1.97981986
77Pili torti (HP:0003777)1.97794705
78Vascular tortuosity (HP:0004948)1.96987907
79Increased variability in muscle fiber diameter (HP:0003557)1.96549756
80Neuronal loss in central nervous system (HP:0002529)1.95674344
81Reticulocytosis (HP:0001923)1.93820446
82Cupped ribs (HP:0000887)1.91623519
83Abnormality of the Achilles tendon (HP:0005109)1.87686331
84Arterial tortuosity (HP:0005116)1.87355839
85Emphysema (HP:0002097)1.87237589
86Myocardial infarction (HP:0001658)1.86816308
87Mitral regurgitation (HP:0001653)1.86606505
88Amyloidosis (HP:0011034)1.86565593
89Orchitis (HP:0100796)1.86198542
90Myoglobinuria (HP:0002913)1.85341523
91Bladder diverticulum (HP:0000015)1.85240810
92Recurrent bacterial skin infections (HP:0005406)1.85075964
93Scapular winging (HP:0003691)1.85030237
94Spinal rigidity (HP:0003306)1.83793238
95Abnormality of skeletal muscle fiber size (HP:0012084)1.83594169
96Natal tooth (HP:0000695)1.83564258
97Hyperparathyroidism (HP:0000843)1.82087324
98Dilatation of the ascending aorta (HP:0005111)1.81656877
99Increased density of long bones (HP:0006392)1.81375597
100Centrally nucleated skeletal muscle fibers (HP:0003687)1.80847362
101J-shaped sella turcica (HP:0002680)1.78632359
102Exercise-induced myalgia (HP:0003738)1.78339748
103Malnutrition (HP:0004395)1.77462532
104Hydroxyprolinuria (HP:0003080)1.76957640
105Abnormality of proline metabolism (HP:0010907)1.76957640
106Disproportionate tall stature (HP:0001519)1.76788376
107Joint stiffness (HP:0001387)1.76747638
108EMG: myopathic abnormalities (HP:0003458)1.76443774
109Palmoplantar hyperkeratosis (HP:0000972)1.76361363
110Glomerulonephritis (HP:0000099)1.75601476
111Urethral obstruction (HP:0000796)1.75395112
112Dysmetric saccades (HP:0000641)1.75107357
113Blue sclerae (HP:0000592)1.74912801
114Apathy (HP:0000741)1.74407827
115Abnormality of the gastric mucosa (HP:0004295)1.72645693
116Pustule (HP:0200039)1.72432441
117Myositis (HP:0100614)1.72134603
118Abnormal atrioventricular conduction (HP:0005150)1.71872501
119Generalized amyotrophy (HP:0003700)1.71329612
120Hemorrhage of the eye (HP:0011885)1.70287175
121Abnormality of the ischium (HP:0003174)1.70227900
122Metaphyseal cupping (HP:0003021)1.70194787
123Subaortic stenosis (HP:0001682)1.69770550
124Abnormality of the left ventricular outflow tract (HP:0011103)1.69770550
125Nail dystrophy (HP:0008404)1.69432810
126Mesangial abnormality (HP:0001966)1.69112668
127Hyperextensible skin (HP:0000974)1.68575340
128Abnormality of the distal phalanx of the thumb (HP:0009617)1.68408032
129Frequent falls (HP:0002359)1.68097450
130Increased IgE level (HP:0003212)1.67994502
131Axonal loss (HP:0003447)1.64818540
132Bowed forearm bones (HP:0003956)1.64137562
133Bowing of the arm (HP:0006488)1.64137562
134Distal lower limb muscle weakness (HP:0009053)1.63880944
135Bone pain (HP:0002653)1.63611741
136Myopathic facies (HP:0002058)1.63422788
137Deep venous thrombosis (HP:0002625)1.63249164
138Diminished motivation (HP:0000745)1.62594441
139Neonatal short-limb short stature (HP:0008921)1.62529585
140Abdominal distention (HP:0003270)1.62095421
141Esophageal varix (HP:0002040)1.61999345
142Stridor (HP:0010307)1.61724332
143Turricephaly (HP:0000262)1.61399216
144Parakeratosis (HP:0001036)1.61360503
145Abnormality of the acetabulum (HP:0003170)1.60636407
146Slender build (HP:0001533)1.60454434
147Hamartoma of the eye (HP:0010568)1.58480178
148Ventricular arrhythmia (HP:0004308)1.57635252
149Abnormality of the 1st metacarpal (HP:0010009)1.57277669
150Plantar hyperkeratosis (HP:0007556)1.57051603
151Lipoatrophy (HP:0100578)1.56930977
152Rhabdomyolysis (HP:0003201)1.56079961
153Enlarged penis (HP:0000040)1.56006996
154Heart block (HP:0012722)1.55657598
155Round ear (HP:0100830)1.54184487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.65874564
2IRAK33.68820323
3ERN13.54978341
4PKN23.38426831
5MAP3K102.87174247
6PRPF4B2.76159438
7CDK122.68285777
8TTN2.61291615
9RIPK12.47609991
10EEF2K2.35963557
11ICK2.10997291
12TAOK22.07105027
13PTK62.06257087
14BMX2.00298101
15LATS11.99056654
16DDR21.95570006
17PDGFRA1.80105868
18MAP3K131.78708495
19SIK11.73063929
20EPHB11.69120594
21DMPK1.65164888
22STK101.64753387
23MAP3K141.60030636
24EPHA21.59810632
25TAOK11.57667940
26SMG11.52682474
27LRRK21.41740696
28BLK1.41354213
29NME21.41062578
30PRKG21.36571350
31RIPK41.34492647
32PAK41.32280511
33MST1R1.28778483
34PTK21.28416912
35CAMK1D1.27206344
36MOS1.27042751
37TESK11.25173755
38LMTK21.23075074
39ALK1.18087937
40MARK21.16267145
41MAP3K111.13154078
42MTOR1.12297654
43IRAK41.10070745
44SIK31.09933297
45MAP4K11.05281388
46LATS21.04420284
47MAP3K31.02196068
48STK381.01900178
49FRK1.01641926
50MAP3K70.97029122
51MAP3K60.96820881
52CAMK1G0.96374718
53GRK60.95841104
54PAK20.93846525
55NTRK10.93523427
56JAK30.92508567
57MAP2K30.91188919
58TGFBR20.88693044
59EPHB20.88536830
60MAPKAPK30.87357490
61CDK60.86925972
62RPS6KB20.86632349
63MAP2K20.85250623
64FGR0.85204214
65PDGFRB0.84427163
66STK30.82629440
67TYRO30.81851845
68MET0.81845623
69ARAF0.80558187
70KSR20.80087184
71SIK20.79138675
72GRK70.79036991
73CSK0.78829853
74MAP3K80.76217331
75TBK10.74255846
76MAP3K10.71335846
77FGFR40.69078681
78CDC42BPA0.68275592
79IRAK20.67848796
80NEK10.67798299
81MATK0.67300281
82MAPK70.67246099
83NEK90.66328487
84HIPK20.65294224
85TRPM70.63401852
86MAP2K60.62213138
87MST40.61945588
88ABL20.61609380
89PRKD10.60456033
90CAMKK10.59408342
91RET0.59395509
92MAPK120.59391998
93PDK10.59084285
94TYK20.58402332
95PRKD20.58320033
96PRKAA20.57891078
97RPS6KA10.57657357
98DYRK1B0.57569106
99IKBKB0.57550944
100FER0.57120134
101CHUK0.56815448
102ILK0.56508111
103PIK3CA0.54948928
104MAP3K20.53724247
105PIM10.51952223
106TAOK30.51149813
107MAPK110.50910276
108JAK10.50799769
109IKBKE0.50608985
110RPS6KA40.50377211
111SCYL20.50296298
112RPS6KL10.50291836
113RPS6KC10.50291836
114PRKD30.49751850
115JAK20.49245893
116MAPKAPK20.49096426
117PAK60.47902587
118SGK30.47825034
119PIM20.47546082
120PRKAA10.47331404
121GSK3A0.46288597
122RPS6KA60.46048533
123FLT30.45587408
124MAP2K10.45292266
125FGFR30.43259659
126MAP3K90.43195241
127LIMK10.42792521
128PDPK10.41781380
129PAK30.40468192
130CSF1R0.39808531
131FGFR10.39696902
132HCK0.39115306
133IRAK10.38925984
134CDK40.38707999
135RPS6KA20.38689638
136TNK20.38301782
137MAPK40.38284730
138AKT20.37213261
139ZAP700.36580028
140PRKCH0.35392290

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.67444564
2Fat digestion and absorption_Homo sapiens_hsa049752.20366890
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92206240
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.76617745
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75258513
6Bladder cancer_Homo sapiens_hsa052191.70471222
7Chronic myeloid leukemia_Homo sapiens_hsa052201.70283158
8Galactose metabolism_Homo sapiens_hsa000521.59119844
9Adherens junction_Homo sapiens_hsa045201.55911896
10mTOR signaling pathway_Homo sapiens_hsa041501.53907382
11Proteoglycans in cancer_Homo sapiens_hsa052051.50465147
12Focal adhesion_Homo sapiens_hsa045101.47325630
13Pertussis_Homo sapiens_hsa051331.43641514
14Prion diseases_Homo sapiens_hsa050201.43027110
15Mineral absorption_Homo sapiens_hsa049781.41576945
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.41093789
17Malaria_Homo sapiens_hsa051441.40809315
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40581778
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38461478
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.38388022
21Protein digestion and absorption_Homo sapiens_hsa049741.38349844
22Amoebiasis_Homo sapiens_hsa051461.37302145
23Insulin resistance_Homo sapiens_hsa049311.37141502
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36999323
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.34925572
26Lysine degradation_Homo sapiens_hsa003101.34167297
27Staphylococcus aureus infection_Homo sapiens_hsa051501.32249232
28Dilated cardiomyopathy_Homo sapiens_hsa054141.32093073
29Small cell lung cancer_Homo sapiens_hsa052221.30931971
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.27572593
31ECM-receptor interaction_Homo sapiens_hsa045121.26561076
32Fructose and mannose metabolism_Homo sapiens_hsa000511.25096657
33Caffeine metabolism_Homo sapiens_hsa002321.24887228
34VEGF signaling pathway_Homo sapiens_hsa043701.23884708
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.21693010
36GnRH signaling pathway_Homo sapiens_hsa049121.20450842
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20012466
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15431828
39* Acute myeloid leukemia_Homo sapiens_hsa052211.12746596
40Viral myocarditis_Homo sapiens_hsa054161.11647729
41Nitrogen metabolism_Homo sapiens_hsa009101.09966798
42Toxoplasmosis_Homo sapiens_hsa051451.09756754
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08558280
44Renin-angiotensin system_Homo sapiens_hsa046141.07799384
45Pancreatic cancer_Homo sapiens_hsa052121.06715801
46Bile secretion_Homo sapiens_hsa049761.06128495
47Osteoclast differentiation_Homo sapiens_hsa043801.05951090
48Notch signaling pathway_Homo sapiens_hsa043301.05875400
49HIF-1 signaling pathway_Homo sapiens_hsa040661.05833432
50Phospholipase D signaling pathway_Homo sapiens_hsa040721.05555957
51Dorso-ventral axis formation_Homo sapiens_hsa043201.05385459
52MicroRNAs in cancer_Homo sapiens_hsa052061.05231933
53Influenza A_Homo sapiens_hsa051641.03056255
54Renal cell carcinoma_Homo sapiens_hsa052111.02702781
55Starch and sucrose metabolism_Homo sapiens_hsa005001.02165750
56Hepatitis C_Homo sapiens_hsa051601.02107235
57Endometrial cancer_Homo sapiens_hsa052131.01947174
58Adipocytokine signaling pathway_Homo sapiens_hsa049201.01835041
59NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01606043
60Non-small cell lung cancer_Homo sapiens_hsa052231.00001107
61Rheumatoid arthritis_Homo sapiens_hsa053230.99554553
62Tight junction_Homo sapiens_hsa045300.99526233
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97709630
64Leishmaniasis_Homo sapiens_hsa051400.96497557
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94420557
66Insulin signaling pathway_Homo sapiens_hsa049100.94323846
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91439496
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91385812
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90181043
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89103592
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.88626544
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87499432
73Chemokine signaling pathway_Homo sapiens_hsa040620.87257299
74Type II diabetes mellitus_Homo sapiens_hsa049300.87159998
75AMPK signaling pathway_Homo sapiens_hsa041520.86554866
76Thyroid cancer_Homo sapiens_hsa052160.85636563
77Phagosome_Homo sapiens_hsa041450.85542543
78Glioma_Homo sapiens_hsa052140.85214275
79African trypanosomiasis_Homo sapiens_hsa051430.84768076
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84662654
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.82936118
82Apoptosis_Homo sapiens_hsa042100.82802535
83B cell receptor signaling pathway_Homo sapiens_hsa046620.81279577
84Prolactin signaling pathway_Homo sapiens_hsa049170.81094921
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80648163
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80110288
87TNF signaling pathway_Homo sapiens_hsa046680.79799969
88Carbon metabolism_Homo sapiens_hsa012000.78220365
89Vibrio cholerae infection_Homo sapiens_hsa051100.77187875
90Arginine biosynthesis_Homo sapiens_hsa002200.76063451
91ErbB signaling pathway_Homo sapiens_hsa040120.75108166
92T cell receptor signaling pathway_Homo sapiens_hsa046600.74804240
93Complement and coagulation cascades_Homo sapiens_hsa046100.74205781
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73886790
95Sphingolipid metabolism_Homo sapiens_hsa006000.73799978
96Hippo signaling pathway_Homo sapiens_hsa043900.73630679
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73459670
98Salmonella infection_Homo sapiens_hsa051320.73149746
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72964233
100Platelet activation_Homo sapiens_hsa046110.71146998
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70938037
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.70825357
103Fatty acid biosynthesis_Homo sapiens_hsa000610.70437594
104Prostate cancer_Homo sapiens_hsa052150.69509317
105Shigellosis_Homo sapiens_hsa051310.66529586
106Estrogen signaling pathway_Homo sapiens_hsa049150.66365425
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65919906
108Biosynthesis of amino acids_Homo sapiens_hsa012300.65763223
109MAPK signaling pathway_Homo sapiens_hsa040100.64834790
110Measles_Homo sapiens_hsa051620.64613841
111Choline metabolism in cancer_Homo sapiens_hsa052310.64577701
112* PPAR signaling pathway_Homo sapiens_hsa033200.64286331
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64155009
114Tuberculosis_Homo sapiens_hsa051520.64094860
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62964943
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62306535
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61797348
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61328071
119Hematopoietic cell lineage_Homo sapiens_hsa046400.59612792
120Hepatitis B_Homo sapiens_hsa051610.59212199
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59166313
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58798403
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58393390
124Endocytosis_Homo sapiens_hsa041440.57998232
125FoxO signaling pathway_Homo sapiens_hsa040680.57997068
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57773499
127Glycerolipid metabolism_Homo sapiens_hsa005610.57256765
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.56741361
129Sulfur metabolism_Homo sapiens_hsa009200.56106879
130Fatty acid degradation_Homo sapiens_hsa000710.55441768
131Long-term potentiation_Homo sapiens_hsa047200.55371941
132Allograft rejection_Homo sapiens_hsa053300.54106417
133Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53052848
134Colorectal cancer_Homo sapiens_hsa052100.53040866
135Legionellosis_Homo sapiens_hsa051340.52899017
136Lysosome_Homo sapiens_hsa041420.52194427
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52166445
138Rap1 signaling pathway_Homo sapiens_hsa040150.51873042
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49857718

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