PPARG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)8.54390396
2* regulation of sequestering of triglyceride (GO:0010889)7.81532023
3triglyceride catabolic process (GO:0019433)6.41208947
4* brown fat cell differentiation (GO:0050873)6.24004806
5branching involved in labyrinthine layer morphogenesis (GO:0060670)6.14905462
6valine metabolic process (GO:0006573)5.88953578
7acylglycerol catabolic process (GO:0046464)5.81451762
8neutral lipid catabolic process (GO:0046461)5.81451762
9positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)5.49978366
10fatty acid transmembrane transport (GO:1902001)5.48074678
11biotin metabolic process (GO:0006768)5.41136390
12regulation of tight junction assembly (GO:2000810)5.34364835
13positive regulation of fatty acid beta-oxidation (GO:0032000)5.20550782
14* white fat cell differentiation (GO:0050872)5.12014836
15positive regulation of glomerulus development (GO:0090193)5.05249508
16regulation of receptor binding (GO:1900120)5.02879250
17* regulation of cholesterol storage (GO:0010885)5.00904950
18fatty acid beta-oxidation (GO:0006635)4.98421552
19carnitine shuttle (GO:0006853)4.88595146
20triglyceride biosynthetic process (GO:0019432)4.62627119
21lipid storage (GO:0019915)4.62177053
22lipid particle organization (GO:0034389)4.62149960
23positive regulation of lipid storage (GO:0010884)4.56937682
24regulation of gonadotropin secretion (GO:0032276)4.53719447
25acylglycerol biosynthetic process (GO:0046463)4.44315806
26neutral lipid biosynthetic process (GO:0046460)4.44315806
27branched-chain amino acid catabolic process (GO:0009083)4.28583576
28serine family amino acid catabolic process (GO:0009071)4.28254238
29fatty acid catabolic process (GO:0009062)4.26105380
30* fatty acid oxidation (GO:0019395)4.25413474
31glycerolipid catabolic process (GO:0046503)4.24016291
32* positive regulation of fatty acid oxidation (GO:0046321)4.21000329
33branched-chain amino acid metabolic process (GO:0009081)4.19552855
34plasma lipoprotein particle clearance (GO:0034381)4.19037761
35* lipid oxidation (GO:0034440)4.17201767
36regulation of fatty acid beta-oxidation (GO:0031998)4.15085455
37regulation of glomerulus development (GO:0090192)4.05081024
38* regulation of fatty acid oxidation (GO:0046320)4.03856964
39positive regulation of lipid catabolic process (GO:0050996)4.03218554
40* negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.02457976
41negative regulation of protein autophosphorylation (GO:0031953)4.01434592
42regulation of triglyceride catabolic process (GO:0010896)4.00184246
43alpha-linolenic acid metabolic process (GO:0036109)3.99206972
44carnitine transmembrane transport (GO:1902603)3.93014267
45regulation of plasminogen activation (GO:0010755)3.92654768
46NADH metabolic process (GO:0006734)3.90302910
47diacylglycerol metabolic process (GO:0046339)3.86264671
48tricarboxylic acid cycle (GO:0006099)3.84377521
49regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.82591970
50peroxisome fission (GO:0016559)3.82213660
51acyl-CoA biosynthetic process (GO:0071616)3.79729270
52thioester biosynthetic process (GO:0035384)3.79729270
53wound healing, spreading of epidermal cells (GO:0035313)3.78542425
54triglyceride metabolic process (GO:0006641)3.74063332
55fatty-acyl-CoA biosynthetic process (GO:0046949)3.74057651
56transcytosis (GO:0045056)3.68815800
57amino-acid betaine transport (GO:0015838)3.61897421
58carnitine transport (GO:0015879)3.61897421
59retinol metabolic process (GO:0042572)3.59553232
60fatty-acyl-CoA metabolic process (GO:0035337)3.57387445
61* regulation of macrophage derived foam cell differentiation (GO:0010743)3.54950645
62spindle assembly involved in mitosis (GO:0090307)3.53929792
63acylglycerol metabolic process (GO:0006639)3.52537842
64tricarboxylic acid metabolic process (GO:0072350)3.52336715
65long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.51536205
66mitochondrion morphogenesis (GO:0070584)3.51532127
67protein heterotrimerization (GO:0070208)3.48982135
68neutral lipid metabolic process (GO:0006638)3.46609395
69acetyl-CoA metabolic process (GO:0006084)3.45313966
70glycerol metabolic process (GO:0006071)3.42568381
71negative regulation of kidney development (GO:0090185)3.41570516
72long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.41251824
73* regulation of lipid storage (GO:0010883)3.40211207
74regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.39446122
75primary alcohol metabolic process (GO:0034308)3.39346016
76triglyceride homeostasis (GO:0070328)3.38646201
77acylglycerol homeostasis (GO:0055090)3.38646201
78coenzyme A biosynthetic process (GO:0015937)3.37611840
79NADPH regeneration (GO:0006740)3.37567467
80regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.37235921
81positive regulation of triglyceride metabolic process (GO:0090208)3.35693058
82pentose-phosphate shunt (GO:0006098)3.35161639
83fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.33183526
84* positive regulation of fatty acid metabolic process (GO:0045923)3.32522390
85monocarboxylic acid catabolic process (GO:0072329)3.31016054
86positive regulation of cholesterol transport (GO:0032376)3.30219427
87positive regulation of sterol transport (GO:0032373)3.30219427
88intracellular lipid transport (GO:0032365)3.29901820
89retina vasculature morphogenesis in camera-type eye (GO:0061299)3.29299988
90flavonoid metabolic process (GO:0009812)3.27784052
91regulation of triglyceride metabolic process (GO:0090207)3.26276925
92aminoglycoside antibiotic metabolic process (GO:0030647)3.24741195
93* negative regulation of lipid storage (GO:0010888)3.24694774
94positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.24218265
95positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.23854865
96sulfur amino acid catabolic process (GO:0000098)3.20482781
97carnitine metabolic process (GO:0009437)3.19338972
98ethanol oxidation (GO:0006069)3.18612991
99negative regulation of macrophage differentiation (GO:0045650)3.18090395
100desmosome organization (GO:0002934)3.17588136
101regulation of triglyceride biosynthetic process (GO:0010866)3.17191669
102positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.14752133
103triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.14484428
104vascular endothelial growth factor signaling pathway (GO:0038084)3.14130831
105apoptotic cell clearance (GO:0043277)3.13850553
106negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.13005496
107mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.11344575
108mitochondrial respiratory chain complex I assembly (GO:0032981)3.11344575
109NADH dehydrogenase complex assembly (GO:0010257)3.11344575
110negative regulation of granulocyte differentiation (GO:0030853)3.11274693
111negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.10336571
112succinate metabolic process (GO:0006105)3.08531987
113positive regulation of cholesterol efflux (GO:0010875)3.07181325
114complement activation, alternative pathway (GO:0006957)3.07130239
115fatty acid homeostasis (GO:0055089)3.06747285
116regulation of lipid catabolic process (GO:0050994)3.03817537
117phagocytosis, recognition (GO:0006910)3.03734950
118positive regulation of glycolytic process (GO:0045821)3.02968593
119prostate gland growth (GO:0060736)3.00962577
120alditol metabolic process (GO:0019400)2.99405065
121somite development (GO:0061053)2.98946671
122regulation of acyl-CoA biosynthetic process (GO:0050812)2.97369894
123positive regulation of triglyceride lipase activity (GO:0061365)2.96593283
124positive regulation of lipoprotein lipase activity (GO:0051006)2.96593283
125homocysteine metabolic process (GO:0050667)2.96048978
126negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.94104433
127cellular lipid catabolic process (GO:0044242)2.93790190
128positive regulation of cellular response to insulin stimulus (GO:1900078)2.93686930
129epoxygenase P450 pathway (GO:0019373)2.93346379
130growth hormone receptor signaling pathway (GO:0060396)2.92662823
131negative regulation of lipase activity (GO:0060192)2.89433974
132mitochondrial fusion (GO:0008053)2.88752765
1332-oxoglutarate metabolic process (GO:0006103)2.88104594
134positive regulation of glucose import (GO:0046326)2.87467880
135negative regulation of cartilage development (GO:0061037)2.86543160
136regulation of cell proliferation involved in kidney development (GO:1901722)2.85550855
137regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.85506549
138phosphatidic acid biosynthetic process (GO:0006654)2.84573156
139phosphatidic acid metabolic process (GO:0046473)2.84573156
140phospholipid homeostasis (GO:0055091)2.83892635
141myelination in peripheral nervous system (GO:0022011)2.82663901
142peripheral nervous system axon ensheathment (GO:0032292)2.82663901
143regulation of coenzyme metabolic process (GO:0051196)2.80674135
144regulation of cofactor metabolic process (GO:0051193)2.80674135
145cell differentiation involved in embryonic placenta development (GO:0060706)2.78652459
146negative regulation of phagocytosis (GO:0050765)2.77811108
147daunorubicin metabolic process (GO:0044597)2.74581934
148polyketide metabolic process (GO:0030638)2.74581934
149doxorubicin metabolic process (GO:0044598)2.74581934
150positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.73789025
151negative regulation of cardiac muscle tissue development (GO:0055026)2.73457959
152* cellular response to lithium ion (GO:0071285)2.69456796
153regulation of energy homeostasis (GO:2000505)2.69443120
154negative regulation of heart growth (GO:0061117)2.69285024
155negative regulation of cardiac muscle tissue growth (GO:0055022)2.69285024
156folic acid-containing compound biosynthetic process (GO:0009396)2.69020756
157positive regulation of triglyceride biosynthetic process (GO:0010867)2.67959124
158negative regulation of nitric-oxide synthase activity (GO:0051001)2.67597758
159regulation of vitamin metabolic process (GO:0030656)2.67238605
160L-ascorbic acid metabolic process (GO:0019852)2.66885218
161epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.66303651
162response to nitrosative stress (GO:0051409)2.66173017

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human6.03777373
2TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse5.63290646
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.20250476
4CLOCK_20551151_ChIP-Seq_293T_Human4.05083542
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.56089576
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.26367653
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.19369665
8* LXR_22158963_ChIP-Seq_LIVER_Mouse3.13874917
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.94144696
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84631575
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.36987278
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.32464500
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.29700380
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.21128004
15* PPARG_19300518_ChIP-PET_3T3-L1_Mouse11.8115703
16PPAR_26484153_Chip-Seq_NCI-H1993_Human1.96718468
17* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.96102070
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95847215
19* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.89701426
20* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.81723098
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78413856
22SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.71729965
23* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.69640800
24GATA1_22025678_ChIP-Seq_K562_Human1.65882042
25* AHR_22903824_ChIP-Seq_MCF-7_Human1.65013911
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64295444
27STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.63197231
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54747829
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52781312
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.51302566
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51071691
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.50889915
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50106116
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48430545
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47718580
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47708164
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44640178
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.44298647
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44137036
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44137036
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.43399321
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38943280
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.37565450
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.35522846
45TP53_20018659_ChIP-ChIP_R1E_Mouse1.33330701
46PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.32947851
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30756258
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27535062
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26222097
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25637586
51VDR_24787735_ChIP-Seq_THP-1_Human1.24125348
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23348274
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23251520
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23251520
55* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22213839
56* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21825944
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21096663
58* SOX2_20726797_ChIP-Seq_SW620_Human1.20905167
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.20848499
60* CJUN_26792858_Chip-Seq_BT549_Human1.20199619
61* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19882516
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.17469061
63MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15763184
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15573047
65SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14991154
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14572177
67* TBX20_22328084_ChIP-Seq_HEART_Mouse1.14530707
68* TBX20_22080862_ChIP-Seq_HEART_Mouse1.14530707
69RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12415373
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12221024
71SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12197270
72STAT1_20625510_ChIP-Seq_HELA_Human1.10589102
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10172894
74* GATA6_25053715_ChIP-Seq_YYC3_Human1.09604224
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09431266
76BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08462613
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08233659
78LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07862152
79RXR_22108803_ChIP-Seq_LS180_Human1.06472250
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06384989
81TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.06286050
82CDX2_20551321_ChIP-Seq_CACO-2_Human1.04678555
83IRF8_21731497_ChIP-ChIP_J774_Mouse1.03118127
84TP53_22127205_ChIP-Seq_IMR90_Human1.02984723
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.01753025
86* ARNT_22903824_ChIP-Seq_MCF-7_Human0.99549796
87UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99385455
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99113999
89* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97652473
90SMAD_19615063_ChIP-ChIP_OVARY_Human0.97364985
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97136765
92YY1_22570637_ChIP-Seq_MALME-3M_Human0.96073086
93GATA4_25053715_ChIP-Seq_YYC3_Human0.94095946
94ELK3_25401928_ChIP-Seq_HUVEC_Human0.93378953
95ESR1_21235772_ChIP-Seq_MCF-7_Human0.93108314
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92697179
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92639613
98* FOXA2_19822575_ChIP-Seq_HepG2_Human0.92018787
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90191787
100RUNX_20019798_ChIP-Seq_JUKART_Human0.89752698
101P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88538281
102JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88445070
103ZNF263_19887448_ChIP-Seq_K562_Human0.87848696
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87356220
105ATF3_27146783_Chip-Seq_COLON_Human0.87348810
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87142516
107FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86830301
108IRF8_27001747_Chip-Seq_BMDM_Mouse0.86103985
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85377871
110SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.84767960
111RACK7_27058665_Chip-Seq_MCF-7_Human0.84577445
112P68_20966046_ChIP-Seq_HELA_Human0.84515664
113* HNF4A_19822575_ChIP-Seq_HepG2_Human0.83846013
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.83594489
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.83594489
116* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82970873
117P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82853767
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82373622
119* CDX2_22108803_ChIP-Seq_LS180_Human0.81448902
120* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81419327
121SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81145074
122GATA3_24758297_ChIP-Seq_MCF-7_Human0.81050510
123TDRD3_21172665_ChIP-Seq_MCF-7_Human0.81006929
124GATA1_19941826_ChIP-Seq_K562_Human0.80612449
125* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80332800
126STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.80151624
127GATA2_19941826_ChIP-Seq_K562_Human0.79956372
128FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79693034
129ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79394632
130* EP300_21415370_ChIP-Seq_HL-1_Mouse0.78299469
131GBX2_23144817_ChIP-Seq_PC3_Human0.77968119
132* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.77818114
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.76579515
134* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.76329862
135ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.75975361
136KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.73382704
137FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71386643
138SPI1_23127762_ChIP-Seq_K562_Human0.70239356

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005670_abnormal_white_adipose5.47867636
2* MP0005666_abnormal_adipose_tissue4.65011062
3* MP0004130_abnormal_muscle_cell4.41181359
4MP0008438_abnormal_cutaneous_collagen3.96150122
5* MP0004185_abnormal_adipocyte_glucose3.75407706
6* MP0005375_adipose_tissue_phenotype3.51816978
7MP0000516_abnormal_urinary_system3.37944126
8MP0005367_renal/urinary_system_phenotyp3.37944126
9MP0010329_abnormal_lipoprotein_level3.19297718
10MP0003191_abnormal_cellular_cholesterol2.93190857
11* MP0002971_abnormal_brown_adipose2.89767344
12MP0005646_abnormal_pituitary_gland2.87653327
13MP0009053_abnormal_anal_canal2.80355506
14MP0003315_abnormal_perineum_morphology2.70726067
15MP0003705_abnormal_hypodermis_morpholog2.41031213
16MP0002837_dystrophic_cardiac_calcinosis2.37717336
17MP0005275_abnormal_skin_tensile2.29659978
18MP0002118_abnormal_lipid_homeostasis2.20096802
19* MP0009115_abnormal_fat_cell2.18152241
20* MP0005334_abnormal_fat_pad2.16353358
21* MP0000003_abnormal_adipose_tissue2.13371890
22MP0005365_abnormal_bile_salt2.13282010
23MP0001849_ear_inflammation2.10516273
24MP0002139_abnormal_hepatobiliary_system2.08473824
25MP0004272_abnormal_basement_membrane2.00909533
26MP0000537_abnormal_urethra_morphology1.88088258
27MP0005360_urolithiasis1.83006016
28* MP0000013_abnormal_adipose_tissue1.81998337
29* MP0002970_abnormal_white_adipose1.79863231
30MP0005058_abnormal_lysosome_morphology1.78552381
31MP0000609_abnormal_liver_physiology1.74985950
32MP0002138_abnormal_hepatobiliary_system1.73322020
33MP0005535_abnormal_body_temperature1.72566903
34MP0003011_delayed_dark_adaptation1.70556901
35MP0000343_altered_response_to1.63622617
36MP0001879_abnormal_lymphatic_vessel1.60412366
37MP0002876_abnormal_thyroid_physiology1.59611760
38MP0004782_abnormal_surfactant_physiolog1.59227798
39MP0005448_abnormal_energy_balance1.51289071
40MP0001485_abnormal_pinna_reflex1.48791240
41MP0000049_abnormal_middle_ear1.46735620
42MP0000467_abnormal_esophagus_morphology1.43597092
43MP0008775_abnormal_heart_ventricle1.41964420
44MP0003186_abnormal_redox_activity1.41110390
45* MP0003724_increased_susceptibility_to1.38554548
46MP0001881_abnormal_mammary_gland1.37265237
47MP0003566_abnormal_cell_adhesion1.36528593
48MP0003300_gastrointestinal_ulcer1.36311555
49MP0003828_pulmonary_edema1.35382963
50MP0003690_abnormal_glial_cell1.33805514
51MP0003959_abnormal_lean_body1.33380739
52MP0005647_abnormal_sex_gland1.31813818
53MP0005167_abnormal_blood-brain_barrier1.27918724
54MP0003646_muscle_fatigue1.25258612
55* MP0002078_abnormal_glucose_homeostasis1.23322035
56MP0000534_abnormal_ureter_morphology1.19116901
57MP0006054_spinal_hemorrhage1.18459218
58MP0001764_abnormal_homeostasis1.17232904
59MP0005584_abnormal_enzyme/coenzyme_acti1.15320444
60MP0005085_abnormal_gallbladder_physiolo1.11065865
61MP0010368_abnormal_lymphatic_system1.10160009
62MP0002796_impaired_skin_barrier1.09778232
63MP0002160_abnormal_reproductive_system1.09511062
64MP0003879_abnormal_hair_cell1.06739370
65MP0003045_fibrosis1.05140767
66MP0002896_abnormal_bone_mineralization1.04924939
67MP0006138_congestive_heart_failure1.03084623
68MP0005385_cardiovascular_system_phenoty1.02736596
69MP0001544_abnormal_cardiovascular_syste1.02736596
70MP0008875_abnormal_xenobiotic_pharmacok1.02519689
71MP0008872_abnormal_physiological_respon1.02423670
72MP0009840_abnormal_foam_cell1.01306196
73MP0005332_abnormal_amino_acid1.00892445
74* MP0005319_abnormal_enzyme/_coenzyme1.00838478
75MP0003283_abnormal_digestive_organ1.00654271
76MP0008004_abnormal_stomach_pH0.97224254
77* MP0005452_abnormal_adipose_tissue0.97128756
78MP0006036_abnormal_mitochondrial_physio0.96954591
79MP0002108_abnormal_muscle_morphology0.96531810
80MP0008961_abnormal_basal_metabolism0.95684506
81MP0009643_abnormal_urine_homeostasis0.92966448
82MP0003950_abnormal_plasma_membrane0.92863952
83MP0002166_altered_tumor_susceptibility0.92429649
84* MP0005164_abnormal_response_to0.92197851
85MP0003221_abnormal_cardiomyocyte_apopto0.91772458
86MP0002282_abnormal_trachea_morphology0.91063109
87MP0001756_abnormal_urination0.90768166
88MP0009763_increased_sensitivity_to0.90753706
89MP0000249_abnormal_blood_vessel0.90296139
90MP0003868_abnormal_feces_composition0.89744208
91* MP0002060_abnormal_skin_morphology0.89630712
92MP0000678_abnormal_parathyroid_gland0.89382662
93MP0009780_abnormal_chondrocyte_physiolo0.88456064
94MP0000163_abnormal_cartilage_morphology0.86969674
95MP0002332_abnormal_exercise_endurance0.86428466
96MP0000681_abnormal_thyroid_gland0.86205268
97MP0003252_abnormal_bile_duct0.83648469
98MP0002998_abnormal_bone_remodeling0.83026132
99MP0003937_abnormal_limbs/digits/tail_de0.82158980
100MP0005257_abnormal_intraocular_pressure0.81712970
101MP0002254_reproductive_system_inflammat0.81630573
102MP0003806_abnormal_nucleotide_metabolis0.81388607
103MP0003119_abnormal_digestive_system0.80579271
104* MP0001533_abnormal_skeleton_physiology0.80093954
105MP0000750_abnormal_muscle_regeneration0.80045289
106MP0003942_abnormal_urinary_system0.79239965
107MP0005620_abnormal_muscle_contractility0.77101212
108MP0005503_abnormal_tendon_morphology0.76686158
109MP0003693_abnormal_embryo_hatching0.76117915
110MP0002877_abnormal_melanocyte_morpholog0.75316459
111MP0004858_abnormal_nervous_system0.75009993
112MP0003448_altered_tumor_morphology0.73894106
113MP0010234_abnormal_vibrissa_follicle0.72663963
114MP0003279_aneurysm0.72286944
115MP0001666_abnormal_nutrient_absorption0.71902923
116MP0004233_abnormal_muscle_weight0.70807479
117* MP0000598_abnormal_liver_morphology0.70785932
118MP0004019_abnormal_vitamin_homeostasis0.70693691
119MP0002972_abnormal_cardiac_muscle0.69971397
120* MP0004087_abnormal_muscle_fiber0.69867727
121MP0009384_cardiac_valve_regurgitation0.69135220
122MP0001851_eye_inflammation0.68985044
123MP0002909_abnormal_adrenal_gland0.68959098
124MP0000858_altered_metastatic_potential0.68237132
125MP0000767_abnormal_smooth_muscle0.67741143
126MP0002006_tumorigenesis0.67614346
127MP0002135_abnormal_kidney_morphology0.67198690
128MP0002168_other_aberrant_phenotype0.67180103
129MP0003436_decreased_susceptibility_to0.67094143
130* MP0000627_abnormal_mammary_gland0.65292817
131MP0000383_abnormal_hair_follicle0.65289775
132MP0005595_abnormal_vascular_smooth0.64540340
133MP0001727_abnormal_embryo_implantation0.63810463
134MP0002136_abnormal_kidney_physiology0.63793169
135MP0002115_abnormal_skeleton_extremities0.63598932
136MP0002295_abnormal_pulmonary_circulatio0.63564903
137MP0005330_cardiomyopathy0.63254752
138MP0004043_abnormal_pH_regulation0.63103817
139MP0003303_peritoneal_inflammation0.62280157
140* MP0003953_abnormal_hormone_level0.61867739
141MP0001958_emphysema0.60068321
142* MP0001661_extended_life_span0.59572830
143MP0009250_abnormal_appendicular_skeleto0.58654308
144MP0003453_abnormal_keratinocyte_physiol0.58547748
145MP0001873_stomach_inflammation0.58167197
146MP0000477_abnormal_intestine_morphology0.57908403
147MP0001440_abnormal_grooming_behavior0.55808180

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)7.56963407
2Short 1st metacarpal (HP:0010034)7.56963407
3Abnormality of the 1st metacarpal (HP:0010009)7.04631393
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.83439202
5Abnormality of alanine metabolism (HP:0010916)5.83439202
6Hyperalaninemia (HP:0003348)5.83439202
7Stenosis of the external auditory canal (HP:0000402)5.32662707
8Fused cervical vertebrae (HP:0002949)5.22237051
9Short phalanx of the thumb (HP:0009660)5.04081696
10Hypoglycemic coma (HP:0001325)4.77206265
11Hyperglycinuria (HP:0003108)4.52352424
12Congenital sensorineural hearing impairment (HP:0008527)4.40577005
13Abnormality of fatty-acid metabolism (HP:0004359)4.27255018
14* Acanthosis nigricans (HP:0000956)4.24199628
15* Oligomenorrhea (HP:0000876)4.13016643
16Nausea (HP:0002018)4.08124363
17* Hypertriglyceridemia (HP:0002155)3.98117395
18Myoglobinuria (HP:0002913)3.90975841
19Ectopic kidney (HP:0000086)3.82222416
20Abnormality of the renal collecting system (HP:0004742)3.79047875
21Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.74031460
22Abnormality of glycine metabolism (HP:0010895)3.72478673
23Abnormality of serine family amino acid metabolism (HP:0010894)3.72478673
24Aplasia/Hypoplasia of the hallux (HP:0008362)3.68597622
25Hyperlipoproteinemia (HP:0010980)3.67977261
26Xanthomatosis (HP:0000991)3.62511886
27Myocardial infarction (HP:0001658)3.60071320
28Abnormality of dicarboxylic acid metabolism (HP:0010995)3.58781410
29Dicarboxylic aciduria (HP:0003215)3.58781410
30Carpal bone hypoplasia (HP:0001498)3.56268044
31Duplicated collecting system (HP:0000081)3.52566221
32Short humerus (HP:0005792)3.49043366
33Rhabdomyolysis (HP:0003201)3.45161239
34Epidermoid cyst (HP:0200040)3.44648351
35Bone cyst (HP:0012062)3.41186873
36Abnormality of the distal phalanges of the toes (HP:0010182)3.41085616
37Complement deficiency (HP:0004431)3.39299621
38Hydroxyprolinuria (HP:0003080)3.36120868
39Abnormality of proline metabolism (HP:0010907)3.36120868
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32661113
41Increased connective tissue (HP:0009025)3.21139216
42Increased muscle lipid content (HP:0009058)3.20966391
43Abnormality of the nasal septum (HP:0000419)3.20429233
44Abnormality of the proximal phalanges of the hand (HP:0009834)3.18737543
45Generalized aminoaciduria (HP:0002909)3.11004966
46Hyperammonemia (HP:0001987)3.10745553
47Ketoacidosis (HP:0001993)3.10227034
48Absent thumb (HP:0009777)3.09509930
49Aplasia/hypoplasia of the humerus (HP:0006507)3.09152224
50Ketosis (HP:0001946)3.04114437
51Vaginal fistula (HP:0004320)3.00303990
52Difficulty running (HP:0009046)2.97172299
53Rectal fistula (HP:0100590)2.91698450
54Rectovaginal fistula (HP:0000143)2.91698450
55Hemorrhage of the eye (HP:0011885)2.91263962
56Right ventricular cardiomyopathy (HP:0011663)2.90107532
57Ankle contracture (HP:0006466)2.87028319
58Abnormality of pyrimidine metabolism (HP:0004353)2.83180460
59Cerebral aneurysm (HP:0004944)2.82940898
60Synostosis of carpal bones (HP:0005048)2.80084172
61Pendular nystagmus (HP:0012043)2.76667368
62Abnormal cartilage morphology (HP:0002763)2.75392338
63Hypercholesterolemia (HP:0003124)2.75149203
64Skin nodule (HP:0200036)2.72087951
65Abnormality of the costochondral junction (HP:0000919)2.70348763
66Intestinal fistula (HP:0100819)2.67149175
67Abnormality of carpal bone ossification (HP:0006257)2.65152772
68Ureteral duplication (HP:0000073)2.60718092
69Abnormality of complement system (HP:0005339)2.59181861
70Long foot (HP:0001833)2.57495898
71Paralysis (HP:0003470)2.55282140
72Broad metatarsal (HP:0001783)2.51500481
73Increased variability in muscle fiber diameter (HP:0003557)2.50849090
74Premature rupture of membranes (HP:0001788)2.49300463
75Pigmentary retinal degeneration (HP:0001146)2.47387248
76Follicular hyperkeratosis (HP:0007502)2.46582512
77Aplasia/Hypoplasia involving the musculature (HP:0001460)2.45883648
78Pancreatitis (HP:0001733)2.45466164
79Cupped ribs (HP:0000887)2.35227137
80Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34898409
81Abnormality of glycolipid metabolism (HP:0010969)2.34518120
82Abnormality of liposaccharide metabolism (HP:0010968)2.34518120
83Abnormality of glycosphingolipid metabolism (HP:0004343)2.34518120
84Conjunctival hamartoma (HP:0100780)2.33989988
85Ileus (HP:0002595)2.33638255
86Hepatic necrosis (HP:0002605)2.32783967
87Hyperglycinemia (HP:0002154)2.31799704
88Spinal rigidity (HP:0003306)2.31611580
89Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.31182353
90Flat acetabular roof (HP:0003180)2.29926849
91Growth hormone excess (HP:0000845)2.29249611
92Aortic dissection (HP:0002647)2.26817415
93Type 1 muscle fiber predominance (HP:0003803)2.26378375
94Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.25497023
95Aortic aneurysm (HP:0004942)2.24882437
96Autoimmune thrombocytopenia (HP:0001973)2.23307955
97Multiple enchondromatosis (HP:0005701)2.21390106
98Abnormality of glutamine family amino acid metabolism (HP:0010902)2.20971128
99Renal cortical cysts (HP:0000803)2.20694834
100Abnormality of the middle phalanges of the toes (HP:0010183)2.20650704
101Humeroradial synostosis (HP:0003041)2.20499118
102Synostosis involving the elbow (HP:0003938)2.20499118
103Tetraparesis (HP:0002273)2.18342802
104Absent radius (HP:0003974)2.18199540
105Conjugated hyperbilirubinemia (HP:0002908)2.16977586
106* Insulin-resistant diabetes mellitus (HP:0000831)2.16226989
107Horseshoe kidney (HP:0000085)2.14496199
108Chromsome breakage (HP:0040012)2.13672523
109Chorioretinal atrophy (HP:0000533)2.13540365
110Abnormality of DNA repair (HP:0003254)2.12185445
111Subcapsular cataract (HP:0000523)2.10844610
112Metabolic acidosis (HP:0001942)2.10468782
113Abnormality of skeletal muscle fiber size (HP:0012084)2.10451898
114* Insulin resistance (HP:0000855)2.09818715
115Muscle stiffness (HP:0003552)2.09134881
116Deep venous thrombosis (HP:0002625)2.07061800
117Carpal synostosis (HP:0009702)2.06605842
118Vertebral compression fractures (HP:0002953)2.04359233
119Aplasia involving forearm bones (HP:0009822)2.04172596
120Absent forearm bone (HP:0003953)2.04172596
121Facial diplegia (HP:0001349)2.03620156
122Protrusio acetabuli (HP:0003179)2.03205447
123Large hands (HP:0001176)2.02967019
124Short thumb (HP:0009778)2.02617305
125Palpitations (HP:0001962)2.02017258
126Proximal tubulopathy (HP:0000114)2.01654671
127* Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.00500597
128Axonal loss (HP:0003447)1.99397829
129Lipoatrophy (HP:0100578)1.98536488
130Abnormality of serum amino acid levels (HP:0003112)1.96177757
131Osteomalacia (HP:0002749)1.95392768
132Multiple lipomas (HP:0001012)1.95076365
133Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93730924
134Prominent supraorbital ridges (HP:0000336)1.92475648
135Absent toe (HP:0010760)1.91985721
136Abnormal tarsal ossification (HP:0008369)1.91483512
137Abnormal ossification of hand bones (HP:0005921)1.91417180
138Slender build (HP:0001533)1.90963840
139Neoplasm of the adrenal gland (HP:0100631)1.90711111
140Hyporeflexia of lower limbs (HP:0002600)1.89611967
141Hypoplastic ischia (HP:0003175)1.88189583
142Vomiting (HP:0002013)1.84257318
143Symphalangism affecting the phalanges of the hand (HP:0009773)1.84225433
144Abnormal hand bone ossification (HP:0010660)1.84217146
145Reticulocytopenia (HP:0001896)1.83514348
146Increased cerebral lipofuscin (HP:0011813)1.83380088
147Anal stenosis (HP:0002025)1.83048325
148Increased serum pyruvate (HP:0003542)1.82510867
149Abnormality of the humerus (HP:0003063)1.82467992
150Rickets (HP:0002748)1.81749665
151Aneurysm (HP:0002617)1.81074022
152Neonatal death (HP:0003811)1.81045808
153Ovoid vertebral bodies (HP:0003300)1.80960890
154Lethargy (HP:0001254)1.80718692
155Cortical dysplasia (HP:0002539)1.79955377
156Nonimmune hydrops fetalis (HP:0001790)1.79771629
157Hypergonadotropic hypogonadism (HP:0000815)1.79281875
158Synostosis involving bones of the hand (HP:0004278)1.78968332
159Abnormality of the upper arm (HP:0001454)1.76138638
160Vertebral fusion (HP:0002948)1.75640000
161Esophageal varix (HP:0002040)1.75507774
162Choanal stenosis (HP:0000452)1.75267815
163Cervical subluxation (HP:0003308)1.75096701
164Systemic lupus erythematosus (HP:0002725)1.74881974
165Keratoconus (HP:0000563)1.73629637
166Increased corneal curvature (HP:0100692)1.73629637
167Abnormality of the ischium (HP:0003174)1.73613863
168Methylmalonic aciduria (HP:0012120)1.68775019
169Accelerated skeletal maturation (HP:0005616)1.68385682
170Dysostosis multiplex (HP:0000943)1.68225765
171Hematochezia (HP:0002573)1.68161085
172Renal tubular acidosis (HP:0001947)1.68090777
173Vacuolated lymphocytes (HP:0001922)1.67505950
174Short hallux (HP:0010109)1.66203930
175Cerebral edema (HP:0002181)1.66191399
176Polycythemia (HP:0001901)1.64192925
177Lymphangioma (HP:0100764)1.64173078
178Increased mean platelet volume (HP:0011877)1.63528077
179Ventricular tachycardia (HP:0004756)1.61995826

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.72774952
2MST1R4.48525980
3CAMK1D4.45994773
4EPHA24.10022002
5BCKDK3.52866457
6SIK13.38282531
7ERN13.21355198
8CAMK1G3.02811833
9KDR3.00112392
10PIK3CA2.94509704
11GRK12.91431819
12ACVR1B2.49135290
13PDK32.38528427
14PDK42.38528427
15TIE12.06915642
16RIPK12.05352157
17PDK22.04005715
18CDK82.01491533
19MET1.89580454
20WNK41.85439683
21PKN21.85053297
22STK391.82603995
23FRK1.82384455
24TGFBR21.80500793
25KSR21.63445915
26PAK41.55579860
27LMTK21.54891302
28NME21.47465243
29PDGFRA1.40082517
30MAP3K21.39159067
31JAK11.34885346
32PRKAA21.31055908
33TTN1.28733052
34EPHB21.23459957
35INSRR1.19387061
36ADRBK21.15282778
37FGFR31.14545563
38LATS11.11517835
39DDR21.10736798
40RPS6KB21.08842748
41RET1.05018160
42AKT31.03757397
43CDK61.01415347
44NEK90.99969556
45JAK20.98994782
46ADRBK10.98260396
47FGFR40.92685232
48CAMK10.91515040
49JAK30.91465774
50DMPK0.90489779
51PTK60.89773656
52FLT30.87573611
53PRKG20.86550183
54MYLK0.86005676
55SGK30.85890085
56PDPK10.83783834
57CAMKK20.78819795
58PLK20.76293421
59PHKG20.75551608
60PHKG10.75551608
61FGFR20.73070931
62GRK50.72837524
63PDGFRB0.72468077
64MAP3K30.71281979
65TBK10.68979343
66ICK0.67777427
67EPHB10.67539066
68MAP2K20.67384789
69PDK10.66886376
70PRKAA10.66195572
71IGF1R0.66117447
72PRKCI0.66058386
73STK240.65395786
74FER0.64953770
75LATS20.64235549
76SGK4940.63882747
77SGK2230.63882747
78PRKD20.63268058
79GSK3A0.63189869
80ABL20.61253047
81PRKCH0.61006085
82FGR0.60970777
83MAP2K30.60117618
84* MAP2K10.59391026
85TRPM70.58816704
86IRAK30.58209067
87CSNK1A10.58033756
88TESK10.57006493
89PTK2B0.56703182
90PIM20.55779626
91LRRK20.55672310
92TAOK30.53255948
93SGK20.51795781
94MAPK110.51614539
95PRKCE0.51225754
96CSK0.50788492
97MAP3K10.50246500
98AURKA0.50236770
99MTOR0.48967317
100BMX0.48697576
101STK30.48069026
102BMPR20.47622594
103MAP3K60.47358102
104MAPKAPK30.47169626
105TYK20.46455824
106ARAF0.45078718
107DAPK30.44695348
108PRKD10.44600496
109PAK20.43622972
110PRKACG0.43284904
111ERBB40.42971835
112CAMK2D0.42724336
113NTRK10.42586013
114KIT0.42298486
115EPHA30.41931104
116NME10.41741399
117PRKCD0.41604296
118CAMK2G0.41232785
119INSR0.41226577
120NUAK10.40942137
121MAPK120.40733285
122STK100.40412587
123RPS6KB10.40128462
124MAPK40.39104043
125ILK0.38569687
126FGFR10.37455161
127IRAK10.36962299
128PRKD30.36840658
129CAMK2B0.36611443
130MOS0.34163496
131ABL10.33740362
132SRC0.33014357
133GRK70.32778127
134CSF1R0.31405064
135STK380.30469339
136TGFBR10.29048695
137DAPK20.28220944
138PIK3CG0.27348378
139RPS6KA60.27033878
140CDK40.26786002
141TEC0.26429138
142PTK20.26387067
143DYRK30.26219999
144STK38L0.25757425
145PAK10.25695301
146PLK40.25102152

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006404.20596039
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.98612234
3* PPAR signaling pathway_Homo sapiens_hsa033203.92977822
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.60110393
5Fatty acid degradation_Homo sapiens_hsa000713.44578328
6Fatty acid metabolism_Homo sapiens_hsa012123.44083914
7Fatty acid biosynthesis_Homo sapiens_hsa000613.42972223
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.93441560
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.75565641
10Glycerolipid metabolism_Homo sapiens_hsa005612.39889380
11Pyruvate metabolism_Homo sapiens_hsa006202.04427696
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.03356267
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.02278391
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.89728897
15Carbon metabolism_Homo sapiens_hsa012001.88050638
16Caffeine metabolism_Homo sapiens_hsa002321.84323018
17beta-Alanine metabolism_Homo sapiens_hsa004101.83453684
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.80803368
19Fat digestion and absorption_Homo sapiens_hsa049751.71496366
20Other glycan degradation_Homo sapiens_hsa005111.61251809
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57265918
22Peroxisome_Homo sapiens_hsa041461.54359939
23Butanoate metabolism_Homo sapiens_hsa006501.53309549
24Sulfur metabolism_Homo sapiens_hsa009201.51704880
25Fatty acid elongation_Homo sapiens_hsa000621.49724944
26Nitrogen metabolism_Homo sapiens_hsa009101.47227081
27One carbon pool by folate_Homo sapiens_hsa006701.38779604
28Tryptophan metabolism_Homo sapiens_hsa003801.35566098
29Collecting duct acid secretion_Homo sapiens_hsa049661.35453113
30Staphylococcus aureus infection_Homo sapiens_hsa051501.29033245
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28307373
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26140673
33* AMPK signaling pathway_Homo sapiens_hsa041521.20829449
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.16907845
35Selenocompound metabolism_Homo sapiens_hsa004501.15995660
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.15472722
37Insulin resistance_Homo sapiens_hsa049311.13458619
38Complement and coagulation cascades_Homo sapiens_hsa046101.08507719
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08431435
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03891868
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00561916
42Primary bile acid biosynthesis_Homo sapiens_hsa001200.98799371
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98727653
44Phenylalanine metabolism_Homo sapiens_hsa003600.97398914
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95916005
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94224240
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91278394
48Insulin signaling pathway_Homo sapiens_hsa049100.86948230
49Starch and sucrose metabolism_Homo sapiens_hsa005000.85922030
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81391186
51Arginine biosynthesis_Homo sapiens_hsa002200.78792327
52Pentose phosphate pathway_Homo sapiens_hsa000300.77892940
53ECM-receptor interaction_Homo sapiens_hsa045120.74509640
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74068282
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73249587
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72176456
57Tyrosine metabolism_Homo sapiens_hsa003500.69719019
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69484282
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67370859
60Malaria_Homo sapiens_hsa051440.65770868
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.65410371
62Arginine and proline metabolism_Homo sapiens_hsa003300.64595844
63Bile secretion_Homo sapiens_hsa049760.63894785
64Chemical carcinogenesis_Homo sapiens_hsa052040.63592282
65Folate biosynthesis_Homo sapiens_hsa007900.62121723
66Glucagon signaling pathway_Homo sapiens_hsa049220.61545757
67ABC transporters_Homo sapiens_hsa020100.60622154
68Lysosome_Homo sapiens_hsa041420.58512282
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.53342978
70Type II diabetes mellitus_Homo sapiens_hsa049300.53236233
71Lysine degradation_Homo sapiens_hsa003100.51310122
72Focal adhesion_Homo sapiens_hsa045100.51105588
73Biosynthesis of amino acids_Homo sapiens_hsa012300.50790554
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50478480
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48161983
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.47739402
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46992166
78Sulfur relay system_Homo sapiens_hsa041220.46562923
79Ether lipid metabolism_Homo sapiens_hsa005650.46290823
80Protein digestion and absorption_Homo sapiens_hsa049740.45223122
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43521251
82Ovarian steroidogenesis_Homo sapiens_hsa049130.42656152
83Retinol metabolism_Homo sapiens_hsa008300.40799866
84Arachidonic acid metabolism_Homo sapiens_hsa005900.39498447
85HIF-1 signaling pathway_Homo sapiens_hsa040660.38021768
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37672074
87* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36735272
88Histidine metabolism_Homo sapiens_hsa003400.36010101
89Mineral absorption_Homo sapiens_hsa049780.35936783
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35768063
91Galactose metabolism_Homo sapiens_hsa000520.32142076
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32110654
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.31681829
94Toxoplasmosis_Homo sapiens_hsa051450.31671346
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31182418
96Proteoglycans in cancer_Homo sapiens_hsa052050.30899889
97Amoebiasis_Homo sapiens_hsa051460.30081222
98Renin secretion_Homo sapiens_hsa049240.28617018
99Vitamin B6 metabolism_Homo sapiens_hsa007500.28263529
100N-Glycan biosynthesis_Homo sapiens_hsa005100.26812590
101Sphingolipid metabolism_Homo sapiens_hsa006000.26633525
102Fructose and mannose metabolism_Homo sapiens_hsa000510.26385677
103Acute myeloid leukemia_Homo sapiens_hsa052210.24190640
104Hepatitis C_Homo sapiens_hsa051600.23793199
105Renin-angiotensin system_Homo sapiens_hsa046140.23589644
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23187877
107Glutathione metabolism_Homo sapiens_hsa004800.23139831
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.23051397
109Bladder cancer_Homo sapiens_hsa052190.22373049
110Pertussis_Homo sapiens_hsa051330.22345618
111Basal cell carcinoma_Homo sapiens_hsa052170.20846023
112Vitamin digestion and absorption_Homo sapiens_hsa049770.20410100
113Linoleic acid metabolism_Homo sapiens_hsa005910.20139098
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20081405
115Pancreatic cancer_Homo sapiens_hsa052120.19134907
116Platelet activation_Homo sapiens_hsa046110.18903979
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18894671
118Metabolic pathways_Homo sapiens_hsa011000.18232545
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18129999
120Morphine addiction_Homo sapiens_hsa050320.17143848
121Steroid biosynthesis_Homo sapiens_hsa001000.17130907
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.16680731
123* Osteoclast differentiation_Homo sapiens_hsa043800.16266622
124mTOR signaling pathway_Homo sapiens_hsa041500.16182144
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16030774
126Chronic myeloid leukemia_Homo sapiens_hsa052200.15711877
127Tuberculosis_Homo sapiens_hsa051520.15620431
128TGF-beta signaling pathway_Homo sapiens_hsa043500.14179953
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.13636409
130Adherens junction_Homo sapiens_hsa045200.13575767
131African trypanosomiasis_Homo sapiens_hsa051430.13340703
132Dorso-ventral axis formation_Homo sapiens_hsa043200.11994149

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »