PPARGC1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.78308049
2actin-mediated cell contraction (GO:0070252)5.49986087
3regulation of skeletal muscle contraction (GO:0014819)4.93707093
4melanin biosynthetic process (GO:0042438)4.90351744
5regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.80757237
6cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.76643317
7regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.68050004
8melanin metabolic process (GO:0006582)4.45323072
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.41455285
10cell communication by electrical coupling (GO:0010644)4.40098914
11tricarboxylic acid cycle (GO:0006099)4.39016014
12actomyosin structure organization (GO:0031032)4.28204262
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.24791720
14secondary metabolite biosynthetic process (GO:0044550)4.21170431
15regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.05571529
16actin filament-based movement (GO:0030048)4.02485065
17regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.01995007
18membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.95293687
19negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.93247922
20cell communication involved in cardiac conduction (GO:0086065)3.91300994
21cardiac myofibril assembly (GO:0055003)3.90805993
22fatty acid transmembrane transport (GO:1902001)3.86135238
23skeletal muscle adaptation (GO:0043501)3.85827390
24skeletal muscle contraction (GO:0003009)3.84485249
25regulation of membrane repolarization (GO:0060306)3.83334275
26positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.83159065
27cardiac muscle contraction (GO:0060048)3.80447780
28negative regulation of potassium ion transmembrane transport (GO:1901380)3.69573688
29creatine metabolic process (GO:0006600)3.69539130
30regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.68858840
31regulation of cell communication by electrical coupling (GO:0010649)3.67439081
32vocalization behavior (GO:0071625)3.67254046
33regulation of acyl-CoA biosynthetic process (GO:0050812)3.67090590
34response to inactivity (GO:0014854)3.64303255
35regulation of actin filament-based movement (GO:1903115)3.62519266
36ventricular cardiac muscle cell action potential (GO:0086005)3.55157354
37regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.53787935
38positive regulation of potassium ion transmembrane transport (GO:1901381)3.53042408
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.52315372
40response to mercury ion (GO:0046689)3.51533071
41sarcomere organization (GO:0045214)3.43906996
42carnitine transmembrane transport (GO:1902603)3.41872789
43muscle contraction (GO:0006936)3.41071177
44cellular potassium ion homeostasis (GO:0030007)3.39535177
45mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.37960818
46regulation of cofactor metabolic process (GO:0051193)3.37499476
47regulation of coenzyme metabolic process (GO:0051196)3.37499476
48muscle hypertrophy (GO:0014896)3.35442190
49* response to muscle activity (GO:0014850)3.35402876
50ATP synthesis coupled proton transport (GO:0015986)3.35061873
51energy coupled proton transport, down electrochemical gradient (GO:0015985)3.35061873
52regulation of relaxation of muscle (GO:1901077)3.33363991
53sodium ion export (GO:0071436)3.31715596
54carnitine transport (GO:0015879)3.31507951
55amino-acid betaine transport (GO:0015838)3.31507951
56cardiac muscle tissue morphogenesis (GO:0055008)3.31228108
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.28631782
58L-phenylalanine catabolic process (GO:0006559)3.28631782
59myofibril assembly (GO:0030239)3.27468926
60regulation of short-term neuronal synaptic plasticity (GO:0048172)3.27087139
61cardiac muscle cell development (GO:0055013)3.26754348
62relaxation of cardiac muscle (GO:0055119)3.26414809
63* respiratory electron transport chain (GO:0022904)3.26184212
64membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.25882378
65succinate metabolic process (GO:0006105)3.25470899
66sarcoplasmic reticulum calcium ion transport (GO:0070296)3.23382518
67locomotory exploration behavior (GO:0035641)3.22605175
68muscle tissue morphogenesis (GO:0060415)3.22033638
69regulation of cardiac muscle cell contraction (GO:0086004)3.21698333
70detection of calcium ion (GO:0005513)3.21121792
71ketone body metabolic process (GO:1902224)3.19044610
72* electron transport chain (GO:0022900)3.17130248
73cardiac muscle cell action potential (GO:0086001)3.16845801
74potassium ion import (GO:0010107)3.16810084
75glycogen catabolic process (GO:0005980)3.16510992
76membrane repolarization (GO:0086009)3.14577406
77NADH metabolic process (GO:0006734)3.13602220
78striated muscle atrophy (GO:0014891)3.13315659
79cardiac conduction (GO:0061337)3.12941560
80positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.12037061
81regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.09926413
82membrane repolarization during action potential (GO:0086011)3.09591451
83muscle system process (GO:0003012)3.08575438
84regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.06903004
85cardiac muscle hypertrophy (GO:0003300)3.06409115
86regulation of heart rate by cardiac conduction (GO:0086091)3.06352052
87striated muscle adaptation (GO:0014888)3.06225184
88cardiac muscle cell action potential involved in contraction (GO:0086002)3.05183677
89erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.03897052
90L-phenylalanine metabolic process (GO:0006558)3.03897052
91muscle cell cellular homeostasis (GO:0046716)3.03419871
92cardiac cell development (GO:0055006)3.02084565
93relaxation of muscle (GO:0090075)3.01928399
94regulation of lipoprotein metabolic process (GO:0050746)3.01551300
95regulation of the force of heart contraction (GO:0002026)3.01090767
96ionotropic glutamate receptor signaling pathway (GO:0035235)3.00686557
97positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.99132992
98regulation of potassium ion transmembrane transport (GO:1901379)2.98970682
99synaptic vesicle exocytosis (GO:0016079)2.98551631
100striated muscle contraction (GO:0006941)2.98387291
101tyrosine metabolic process (GO:0006570)2.97757962
1022-oxoglutarate metabolic process (GO:0006103)2.97318539
103glucan catabolic process (GO:0009251)2.97029729
104gamma-aminobutyric acid transport (GO:0015812)2.96971955
105glutamate receptor signaling pathway (GO:0007215)2.96498748
106regulation of striated muscle contraction (GO:0006942)2.96241264
107regulation of protein activation cascade (GO:2000257)2.96027947
108striated muscle hypertrophy (GO:0014897)2.94326435
109proline transport (GO:0015824)2.92313220
110regulation of cardiac muscle contraction (GO:0055117)2.92086481
111regulation of complement activation (GO:0030449)2.92081928
112adult heart development (GO:0007512)2.91774804
113regulation of potassium ion transmembrane transporter activity (GO:1901016)2.90396547
114neuron cell-cell adhesion (GO:0007158)2.87695103
115quaternary ammonium group transport (GO:0015697)2.87175178
116glutamate secretion (GO:0014047)2.84514729
117muscle atrophy (GO:0014889)2.83057826
118regulation of calcium ion transmembrane transporter activity (GO:1901019)2.82717655
119regulation of calcium ion transmembrane transport (GO:1903169)2.82717655
120* regulation of glutamate receptor signaling pathway (GO:1900449)2.82283996
121heart contraction (GO:0060047)2.81188634
122heart process (GO:0003015)2.81188634
123negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79751370
124neuronal action potential propagation (GO:0019227)2.79323656
125calcium-mediated signaling using intracellular calcium source (GO:0035584)2.79254965
126cellular polysaccharide catabolic process (GO:0044247)2.77829258
127oxaloacetate metabolic process (GO:0006107)2.77763339
128synaptic vesicle docking involved in exocytosis (GO:0016081)2.77733667
129alanine transport (GO:0032328)2.77234104
130carnitine shuttle (GO:0006853)2.76417554
131positive regulation of potassium ion transport (GO:0043268)2.76176917
132G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75506366
133striatum development (GO:0021756)2.75012736
134neurotransmitter-gated ion channel clustering (GO:0072578)2.73508398
135dicarboxylic acid biosynthetic process (GO:0043650)2.73219127
136regulation of sarcomere organization (GO:0060297)2.72914042
137negative regulation of calcium ion transmembrane transport (GO:1903170)2.72833580
138negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.72833580
139negative regulation of cytosolic calcium ion concentration (GO:0051481)2.72643264
140regulation of sulfur metabolic process (GO:0042762)2.70020748
141protein localization to synapse (GO:0035418)2.69724582
142* regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.69680307
143muscle filament sliding (GO:0030049)2.69475967
144actin-myosin filament sliding (GO:0033275)2.69475967
145multicellular organismal signaling (GO:0035637)2.68696868
146adrenergic receptor signaling pathway (GO:0071875)2.68032709
147muscle fiber development (GO:0048747)2.67542579
148cardiac muscle adaptation (GO:0014887)2.66681828
149cardiac muscle hypertrophy in response to stress (GO:0014898)2.66681828
150muscle hypertrophy in response to stress (GO:0003299)2.66681828
151membrane depolarization during action potential (GO:0086010)2.64497655
152synaptic vesicle maturation (GO:0016188)2.64385437
153negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.62927760
154neurotransmitter secretion (GO:0007269)2.62202713
155positive regulation of sodium ion transport (GO:0010765)2.60935595
156regulation of heart rate (GO:0002027)2.60720414
157positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.60356476

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.90740882
2GBX2_23144817_ChIP-Seq_PC3_Human3.44749976
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69904740
4* ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.64896592
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62034577
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42223929
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23293579
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23293579
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19205026
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16575210
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11882637
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11474661
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.04570027
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04461379
15ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.04112341
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00485670
17EP300_21415370_ChIP-Seq_HL-1_Mouse2.00149786
18DROSHA_22980978_ChIP-Seq_HELA_Human1.97472708
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97090394
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.95709400
21* RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92966889
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.90980879
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90454968
24AR_21572438_ChIP-Seq_LNCaP_Human1.89201635
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87781499
26TAF15_26573619_Chip-Seq_HEK293_Human1.80110620
27REST_21632747_ChIP-Seq_MESCs_Mouse1.77539086
28* EZH2_27294783_Chip-Seq_ESCs_Mouse1.75900827
29SMAD4_21799915_ChIP-Seq_A2780_Human1.74004127
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.73906360
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72566803
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72522280
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68844806
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.68622753
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68028565
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.66834836
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.66802664
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.62425995
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61727767
40* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61355910
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.56805565
42* P300_19829295_ChIP-Seq_ESCs_Human1.54376760
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52728661
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52072963
45* RXR_22158963_ChIP-Seq_LIVER_Mouse1.51088308
46TBX20_22080862_ChIP-Seq_HEART_Mouse1.48835738
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.46358737
48* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46255211
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45808090
50BCAT_22108803_ChIP-Seq_LS180_Human1.42294709
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42118879
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40889720
53* SMAD3_21741376_ChIP-Seq_EPCs_Human1.40811168
54IGF1R_20145208_ChIP-Seq_DFB_Human1.39781177
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.39622043
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39206956
57VDR_22108803_ChIP-Seq_LS180_Human1.37786678
58ZNF274_21170338_ChIP-Seq_K562_Hela1.37200248
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.36983801
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.36841564
61* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35339500
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.33883521
63* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32504583
64AR_25329375_ChIP-Seq_VCAP_Human1.29981160
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28940053
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28842460
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27969178
68CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26706125
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26671050
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.26323813
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25817949
72* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25003285
73* FOXA2_19822575_ChIP-Seq_HepG2_Human1.24183199
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23509902
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23046596
76PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22551466
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.22061811
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21597966
79* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20708685
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.20575716
81STAT3_23295773_ChIP-Seq_U87_Human1.19916218
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19890392
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19890392
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19734960
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18640040
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18097871
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18087344
88* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18051632
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.17585064
90OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16754780
91CBP_20019798_ChIP-Seq_JUKART_Human1.16534985
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16534985
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16450856
94CJUN_26792858_Chip-Seq_BT549_Human1.15409474
95* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15134996
96AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15037073
97GATA1_22025678_ChIP-Seq_K562_Human1.14795338
98FUS_26573619_Chip-Seq_HEK293_Human1.13552157
99AHR_22903824_ChIP-Seq_MCF-7_Human1.13023644
100SOX2_19829295_ChIP-Seq_ESCs_Human1.11458995
101NANOG_19829295_ChIP-Seq_ESCs_Human1.11458995
102P53_22387025_ChIP-Seq_ESCs_Mouse1.11170935
103* AR_19668381_ChIP-Seq_PC3_Human1.10286078
104* TCF4_23295773_ChIP-Seq_U87_Human1.09983935
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09927824
106TP53_16413492_ChIP-PET_HCT116_Human1.08349024
107ER_23166858_ChIP-Seq_MCF-7_Human1.07961665
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07819015
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07000305
110RING1B_27294783_Chip-Seq_ESCs_Mouse1.06371679
111CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06308011
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06131978
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06131978
114SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05867825
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05826936
116CDX2_22108803_ChIP-Seq_LS180_Human1.05612967
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05120380
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05032693
119TCF4_18268006_ChIP-ChIP_LS174T_Human1.04786230
120IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03391587
121SMAD3_21741376_ChIP-Seq_HESCs_Human1.03338466
122SMAD4_21741376_ChIP-Seq_HESCs_Human1.03300127
123MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.02600822
124TP53_18474530_ChIP-ChIP_U2OS_Human1.02421605
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.01797315
126* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01300288
127KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01054061
128HTT_18923047_ChIP-ChIP_STHdh_Human1.00288486
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00199722
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99320100
131* RUNX2_22187159_ChIP-Seq_PCA_Human0.98115189
132TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97983036
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.95969988
134RXR_22108803_ChIP-Seq_LS180_Human0.95569468
135MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94997459
136ERG_21242973_ChIP-ChIP_JURKAT_Human0.94142044
137* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93917733
138TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92606664
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92563544
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92230708
141BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90850396
142P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89748202
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.88657307
144E2F1_18555785_Chip-Seq_ESCs_Mouse0.88366985
145TBX20_22328084_ChIP-Seq_HEART_Mouse0.87768828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.19959687
2MP0004215_abnormal_myocardial_fiber3.65894666
3MP0004859_abnormal_synaptic_plasticity3.45678023
4MP0000751_myopathy3.34743542
5MP0004084_abnormal_cardiac_muscle3.22954279
6MP0003880_abnormal_central_pattern2.86666271
7MP0004036_abnormal_muscle_relaxation2.57669566
8MP0003635_abnormal_synaptic_transmissio2.53293078
9* MP0003646_muscle_fatigue2.48876031
10MP0003137_abnormal_impulse_conducting2.37895498
11MP0005408_hypopigmentation2.36718460
12MP0005330_cardiomyopathy2.33683725
13MP0000749_muscle_degeneration2.29922924
14MP0009745_abnormal_behavioral_response2.29290007
15* MP0009046_muscle_twitch2.24646048
16MP0005670_abnormal_white_adipose2.23568506
17MP0003195_calcinosis2.23563803
18MP0004270_analgesia2.16235006
19* MP0002972_abnormal_cardiac_muscle2.11207581
20* MP0002064_seizures2.01378828
21MP0002063_abnormal_learning/memory/cond2.01200763
22MP0004145_abnormal_muscle_electrophysio1.97631138
23MP0004130_abnormal_muscle_cell1.96308094
24* MP0004484_altered_response_of1.94100662
25MP0008775_abnormal_heart_ventricle1.92901668
26* MP0005620_abnormal_muscle_contractility1.89827547
27MP0004043_abnormal_pH_regulation1.87562426
28* MP0004085_abnormal_heartbeat1.86993598
29* MP0001486_abnormal_startle_reflex1.85192820
30* MP0002572_abnormal_emotion/affect_behav1.82030341
31MP0002272_abnormal_nervous_system1.77543840
32MP0001440_abnormal_grooming_behavior1.75631515
33MP0003136_yellow_coat_color1.72636964
34MP0005085_abnormal_gallbladder_physiolo1.70192061
35MP0005171_absent_coat_pigmentation1.67754681
36* MP0004087_abnormal_muscle_fiber1.65993565
37MP0001968_abnormal_touch/_nociception1.65805203
38MP0005423_abnormal_somatic_nervous1.62526035
39MP0002139_abnormal_hepatobiliary_system1.56660392
40MP0001501_abnormal_sleep_pattern1.52985496
41MP0002734_abnormal_mechanical_nocicepti1.50584217
42MP0009780_abnormal_chondrocyte_physiolo1.47274424
43MP0001984_abnormal_olfaction1.46354791
44* MP0002067_abnormal_sensory_capabilities1.45009319
45* MP0006138_congestive_heart_failure1.43169262
46* MP0005385_cardiovascular_system_phenoty1.42862654
47* MP0001544_abnormal_cardiovascular_syste1.42862654
48MP0002822_catalepsy1.42722700
49MP0005646_abnormal_pituitary_gland1.37956092
50MP0002735_abnormal_chemical_nociception1.36958852
51MP0005551_abnormal_eye_electrophysiolog1.35254080
52MP0005187_abnormal_penis_morphology1.32545862
53MP0005075_abnormal_melanosome_morpholog1.32373469
54MP0002736_abnormal_nociception_after1.31375635
55* MP0005386_behavior/neurological_phenoty1.31302608
56* MP0004924_abnormal_behavior1.31302608
57MP0008569_lethality_at_weaning1.29721915
58* MP0002106_abnormal_muscle_physiology1.29023058
59MP0004885_abnormal_endolymph1.28747588
60MP0000569_abnormal_digit_pigmentation1.25536391
61MP0004381_abnormal_hair_follicle1.24699471
62MP0010630_abnormal_cardiac_muscle1.22396006
63MP0003045_fibrosis1.21262786
64MP0005365_abnormal_bile_salt1.20840180
65MP0003878_abnormal_ear_physiology1.20446447
66MP0005377_hearing/vestibular/ear_phenot1.20446447
67MP0000747_muscle_weakness1.20423851
68MP0001661_extended_life_span1.18022959
69MP0002557_abnormal_social/conspecific_i1.16615752
70MP0000371_diluted_coat_color1.15766546
71MP0002332_abnormal_exercise_endurance1.14440897
72* MP0006036_abnormal_mitochondrial_physio1.13833955
73MP0002909_abnormal_adrenal_gland1.12410786
74MP0001324_abnormal_eye_pigmentation1.12318340
75MP0002269_muscular_atrophy1.11694354
76MP0004510_myositis1.11512688
77MP0006276_abnormal_autonomic_nervous1.10986412
78* MP0005369_muscle_phenotype1.10855875
79MP0003329_amyloid_beta_deposits1.06746013
80MP0005409_darkened_coat_color1.06422804
81MP0005248_abnormal_Harderian_gland1.06401573
82MP0006035_abnormal_mitochondrial_morpho1.06193177
83MP0001970_abnormal_pain_threshold1.06087544
84MP0002095_abnormal_skin_pigmentation1.05376957
85MP0005451_abnormal_body_composition1.04660392
86MP0000778_abnormal_nervous_system1.03867096
87MP0000750_abnormal_muscle_regeneration1.03806086
88MP0010329_abnormal_lipoprotein_level1.03148440
89MP0002127_abnormal_cardiovascular_syste1.02708958
90MP0001485_abnormal_pinna_reflex1.00634729
91MP0002108_abnormal_muscle_morphology0.99794864
92MP0002877_abnormal_melanocyte_morpholog0.99694193
93MP0002733_abnormal_thermal_nociception0.99687348
94MP0000015_abnormal_ear_pigmentation0.99415239
95MP0004858_abnormal_nervous_system0.98676226
96MP0003252_abnormal_bile_duct0.97513606
97MP0002184_abnormal_innervation0.96731011
98* MP0005535_abnormal_body_temperature0.96635034
99MP0003950_abnormal_plasma_membrane0.95460222
100MP0001529_abnormal_vocalization0.94960194
101MP0002102_abnormal_ear_morphology0.94077636
102* MP0000759_abnormal_skeletal_muscle0.93597859
103MP0002876_abnormal_thyroid_physiology0.93301378
104* MP0002066_abnormal_motor_capabilities/c0.93092458
105MP0005266_abnormal_metabolism0.92866108
106MP0003879_abnormal_hair_cell0.92300813
107MP0001502_abnormal_circadian_rhythm0.92080784
108MP0000230_abnormal_systemic_arterial0.90663310
109MP0005253_abnormal_eye_physiology0.87399551
110MP0000372_irregular_coat_pigmentation0.86885258
111MP0003221_abnormal_cardiomyocyte_apopto0.86761685
112* MP0002882_abnormal_neuron_morphology0.84212217
113* MP0004142_abnormal_muscle_tone0.84183590
114MP0003633_abnormal_nervous_system0.83728019
115MP0005332_abnormal_amino_acid0.83369923
116MP0002638_abnormal_pupillary_reflex0.82791170
117MP0002938_white_spotting0.82456689
118* MP0002229_neurodegeneration0.81875513
119MP0008875_abnormal_xenobiotic_pharmacok0.80370532
120* MP0002971_abnormal_brown_adipose0.80342876
121MP0000013_abnormal_adipose_tissue0.79366864
122MP0003122_maternal_imprinting0.77756946
123MP0001756_abnormal_urination0.77453075
124MP0002090_abnormal_vision0.77321194
125MP0003690_abnormal_glial_cell0.77226755
126MP0005174_abnormal_tail_pigmentation0.76401055
127MP0004147_increased_porphyrin_level0.74767834
128MP0001963_abnormal_hearing_physiology0.71522629
129MP0000733_abnormal_muscle_development0.70390826
130MP0004811_abnormal_neuron_physiology0.70142962
131MP0002075_abnormal_coat/hair_pigmentati0.70005554
132MP0005666_abnormal_adipose_tissue0.67899158
133MP0005360_urolithiasis0.67116193
134MP0000955_abnormal_spinal_cord0.66890779
135* MP0004233_abnormal_muscle_weight0.66472798
136MP0003868_abnormal_feces_composition0.66411139
137* MP0002118_abnormal_lipid_homeostasis0.61967338
138MP0002168_other_aberrant_phenotype0.60761381
139MP0000003_abnormal_adipose_tissue0.58902790
140MP0010368_abnormal_lymphatic_system0.58667179
141MP0005257_abnormal_intraocular_pressure0.57809343

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.41477053
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.10868477
3Nemaline bodies (HP:0003798)7.05346087
4Sudden death (HP:0001699)5.30517285
5Type 1 muscle fiber predominance (HP:0003803)5.09097133
6Focal motor seizures (HP:0011153)4.82313066
7Atrial fibrillation (HP:0005110)4.42308993
8Syncope (HP:0001279)4.41510276
9Exercise-induced myalgia (HP:0003738)4.29725367
10Primary atrial arrhythmia (HP:0001692)4.16412565
11Calf muscle hypertrophy (HP:0008981)3.98981204
12Supraventricular tachycardia (HP:0004755)3.95515287
13Prolonged QT interval (HP:0001657)3.90412812
14Supraventricular arrhythmia (HP:0005115)3.83240868
15Muscle hypertrophy of the lower extremities (HP:0008968)3.71144235
16Exercise-induced muscle cramps (HP:0003710)3.61616150
17Abnormality of the calf musculature (HP:0001430)3.61051143
18Distal arthrogryposis (HP:0005684)3.48254622
19Ventricular tachycardia (HP:0004756)3.47479166
20Myoglobinuria (HP:0002913)3.41943005
21Neck muscle weakness (HP:0000467)3.37623692
22Pheochromocytoma (HP:0002666)3.37239643
23Frequent falls (HP:0002359)3.35359156
24Rimmed vacuoles (HP:0003805)3.29928791
25Acute necrotizing encephalopathy (HP:0006965)3.27815945
26Abnormal mitochondria in muscle tissue (HP:0008316)3.27793822
27Ventricular fibrillation (HP:0001663)3.24486131
28Hyperventilation (HP:0002883)3.23291203
29Ventricular arrhythmia (HP:0004308)3.17406641
30Focal seizures (HP:0007359)3.15854714
31Febrile seizures (HP:0002373)3.05396893
32Bundle branch block (HP:0011710)3.05154466
33Myopathic facies (HP:0002058)3.03750708
34Abnormal EKG (HP:0003115)2.98650607
35Epileptic encephalopathy (HP:0200134)2.97740437
36Palpitations (HP:0001962)2.96795856
37Neuroendocrine neoplasm (HP:0100634)2.94624301
38Progressive macrocephaly (HP:0004481)2.93699127
39Acute encephalopathy (HP:0006846)2.92061860
40Round ear (HP:0100830)2.88227784
41Lipoatrophy (HP:0100578)2.86393186
42Myokymia (HP:0002411)2.85399107
43Ketoacidosis (HP:0001993)2.82900261
44Left ventricular hypertrophy (HP:0001712)2.81999944
45Atonic seizures (HP:0010819)2.78699449
46Centrally nucleated skeletal muscle fibers (HP:0003687)2.78313963
47Right ventricular cardiomyopathy (HP:0011663)2.78220835
48Aplasia/Hypoplasia of the macula (HP:0008059)2.76578659
49EMG: neuropathic changes (HP:0003445)2.69492548
50Central scotoma (HP:0000603)2.66850917
51Distal lower limb muscle weakness (HP:0009053)2.65885777
52Heart block (HP:0012722)2.63352434
53Hyperkalemia (HP:0002153)2.59945273
54Areflexia of lower limbs (HP:0002522)2.58642445
55Mitochondrial inheritance (HP:0001427)2.57628073
56Generalized tonic-clonic seizures (HP:0002069)2.56660016
57Aplasia/Hypoplasia affecting the retina (HP:0008061)2.54833217
58Aplasia/Hypoplasia of the fovea (HP:0008060)2.54673781
59Hypoplasia of the fovea (HP:0007750)2.54673781
60Subaortic stenosis (HP:0001682)2.53708089
61Abnormality of the left ventricular outflow tract (HP:0011103)2.53708089
62Absence seizures (HP:0002121)2.50249530
63Visual hallucinations (HP:0002367)2.49880838
64Hepatic necrosis (HP:0002605)2.49100835
65Complement deficiency (HP:0004431)2.46900014
66Blue irides (HP:0000635)2.44951089
67Dilated cardiomyopathy (HP:0001644)2.44884885
68Generalized muscle weakness (HP:0003324)2.43228308
69Muscle fiber splitting (HP:0003555)2.42936484
70Cerebral edema (HP:0002181)2.41981318
71Increased CSF lactate (HP:0002490)2.40320609
72EMG: myopathic abnormalities (HP:0003458)2.38024343
73Atrioventricular block (HP:0001678)2.37883685
74Increased connective tissue (HP:0009025)2.37465522
75Abnormal atrioventricular conduction (HP:0005150)2.36028200
76Abnormality of the fovea (HP:0000493)2.35072139
77Dysmetric saccades (HP:0000641)2.34203996
78Progressive inability to walk (HP:0002505)2.30738988
79Progressive cerebellar ataxia (HP:0002073)2.30182087
80Hepatocellular necrosis (HP:0001404)2.28055536
81Abnormality of aromatic amino acid family metabolism (HP:0004338)2.26485448
82Dysdiadochokinesis (HP:0002075)2.25494833
83Broad-based gait (HP:0002136)2.24445180
84Deep venous thrombosis (HP:0002625)2.24431426
85Asymmetric septal hypertrophy (HP:0001670)2.23342655
86Hyporeflexia of lower limbs (HP:0002600)2.22498156
87Prolonged partial thromboplastin time (HP:0003645)2.22073509
88Ragged-red muscle fibers (HP:0003200)2.20246026
89Dialeptic seizures (HP:0011146)2.19557088
90Ulnar deviation of the wrist (HP:0003049)2.19080833
91Abnormality of alanine metabolism (HP:0010916)2.18735357
92Hyperalaninemia (HP:0003348)2.18735357
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18735357
94Anxiety (HP:0000739)2.17712209
95Absent phalangeal crease (HP:0006109)2.17223115
96Ocular albinism (HP:0001107)2.17118992
97Scapular winging (HP:0003691)2.16663039
98Abnormality of skeletal muscle fiber size (HP:0012084)2.15286468
99Hypoplastic left heart (HP:0004383)2.14856695
100Proximal amyotrophy (HP:0007126)2.13960144
101Athetosis (HP:0002305)2.13545481
102Muscle stiffness (HP:0003552)2.11594430
103Conjunctival hamartoma (HP:0100780)2.08423794
104Lactic acidosis (HP:0003128)2.05810036
105Increased serum pyruvate (HP:0003542)2.05599174
106Abnormality of glycolysis (HP:0004366)2.05599174
107Hypobetalipoproteinemia (HP:0003563)2.05304516
108Optic disc pallor (HP:0000543)2.05026333
109Ketosis (HP:0001946)2.04577917
110Abnormality of potassium homeostasis (HP:0011042)2.03452546
111Gowers sign (HP:0003391)2.00762624
112Gaze-evoked nystagmus (HP:0000640)2.00434715
113Myotonia (HP:0002486)1.99100416
114Increased variability in muscle fiber diameter (HP:0003557)1.96455990
115Hypoalphalipoproteinemia (HP:0003233)1.94795809
116Abnormal social behavior (HP:0012433)1.94653782
117Impaired social interactions (HP:0000735)1.94653782
118Abnormality of the foot musculature (HP:0001436)1.93653749
119Iris hypopigmentation (HP:0007730)1.93441972
120Hypoglycemic coma (HP:0001325)1.91988427
121Rhabdomyolysis (HP:0003201)1.91612508
122Poor eye contact (HP:0000817)1.90293131
123Abnormal finger flexion creases (HP:0006143)1.89130548
124Exercise intolerance (HP:0003546)1.88599328
125Action tremor (HP:0002345)1.88179293
126Hypolipoproteinemia (HP:0010981)1.87814797
127Hypokalemia (HP:0002900)1.84715342
128Status epilepticus (HP:0002133)1.84172232
129Dicarboxylic aciduria (HP:0003215)1.84080404
130Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84080404
131Increased circulating renin level (HP:0000848)1.83995750
132Hamartoma of the eye (HP:0010568)1.83793277
133Tinnitus (HP:0000360)1.82376155
134Metabolic alkalosis (HP:0200114)1.81963147
135Vascular calcification (HP:0004934)1.81020193
136Increased intramyocellular lipid droplets (HP:0012240)1.80847251
137Increased muscle lipid content (HP:0009058)1.80273752
138Hyperactive renin-angiotensin system (HP:0000841)1.80239901
139Respiratory failure (HP:0002878)1.80192639
140White forelock (HP:0002211)1.80153358
141Abnormality of fatty-acid metabolism (HP:0004359)1.79636366
142Scotoma (HP:0000575)1.79467474
143Foot dorsiflexor weakness (HP:0009027)1.79256458
144Abnormality of monocarboxylic acid metabolism (HP:0010996)1.77961806
145Malignant hyperthermia (HP:0002047)1.77485357
146Difficulty running (HP:0009046)1.76609149
147Truncal ataxia (HP:0002078)1.76251161
148Hyperglycinuria (HP:0003108)1.74986776
149Hypokalemic alkalosis (HP:0001949)1.74286881
150Epidermoid cyst (HP:0200040)1.73170179
151Muscular dystrophy (HP:0003560)1.72788733
152Neoplasm of the adrenal gland (HP:0100631)1.72014244
153Calcaneovalgus deformity (HP:0001848)1.71758081
154Abnormality of complement system (HP:0005339)1.70323012
155Joint hemorrhage (HP:0005261)1.69527405
156Patchy hypopigmentation of hair (HP:0011365)1.66681888
157Generalized hypopigmentation of hair (HP:0011358)1.65427245
158Generalized hypopigmentation (HP:0007513)1.63324371

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK23.10214620
2LATS13.05782484
3PHKG12.95986168
4PHKG22.95986168
5EPHA42.95198668
6NTRK32.83823728
7MUSK2.70352124
8OBSCN2.61608530
9MAP3K42.57586029
10MAP2K72.46010282
11PDK32.43304164
12PDK42.43304164
13FRK2.39654710
14CASK2.07258533
15MYLK1.94780221
16TNIK1.93552617
17WNK41.86947580
18PIK3CG1.84728323
19MAP2K41.80084220
20MAP3K91.74241812
21MARK11.71181690
22STK241.65980986
23ACVR1B1.61578512
24NTRK21.57704089
25PINK11.51353850
26MINK11.49768702
27DMPK1.46079069
28SGK21.43859488
29PRKD31.42463354
30ERBB31.37507103
31PIK3CA1.36573305
32TRPM71.36188652
33PDK21.32028704
34TTN1.28849959
35STK391.27437845
36OXSR11.27428166
37STK381.24478121
38BMPR1B1.24027115
39CAMK2A1.23359124
40PAK31.23334914
41SGK4941.21809451
42SGK2231.21809451
43PAK61.17447515
44INSRR1.16542223
45CAMK2D1.15584608
46* PRKAA21.15437899
47MAP3K121.14531860
48SGK31.12432713
49GRK71.08014134
50WNK31.07721869
51MAPK131.04918924
52PRPF4B1.00198452
53WNK10.98868604
54MAP3K70.98232521
55PLK20.96171227
56DAPK20.94623146
57MAPK120.94292378
58PRKCE0.92309818
59PTK2B0.91759008
60CDK50.91086104
61KSR10.90102718
62AKT30.87330980
63CAMK10.86448524
64NLK0.86290710
65NME10.85362139
66WEE10.85083701
67PRKCG0.84443464
68EPHA30.83216396
69PNCK0.82099392
70NEK10.81744795
71BCKDK0.81683207
72STK38L0.80828971
73KSR20.80393104
74NEK90.78952147
75SGK10.75911152
76MAPKAPK30.74510808
77GRK50.73260376
78FGFR30.72787436
79CDC42BPA0.72297877
80MARK30.72213364
81ROCK10.71701013
82NTRK10.70971282
83CAMK2B0.70814787
84SIK20.70099591
85CAMK2G0.69600293
86CAMKK10.68183527
87TRIB30.67548247
88MST1R0.66898799
89RIPK40.66222067
90PRKAA10.66185761
91TIE10.64767371
92MET0.64555805
93PRKG10.63256084
94CAMK40.62623368
95MAPK70.60963105
96MAP2K10.58930732
97CAMK1G0.58288543
98PRKCH0.57163448
99PKN10.55641300
100PDPK10.55207091
101STK30.54105211
102* PRKACA0.54000315
103PDK10.53071988
104STK110.52562238
105CCNB10.51177611
106MAP3K50.50940991
107PKN20.50282755
108PRKD10.49396062
109CAMKK20.49322131
110UHMK10.48304443
111MAP3K20.48112816
112LATS20.48092015
113MAP3K60.48079738
114RET0.47329175
115FER0.46875247
116PRKACG0.46526621
117NEK60.46203279
118CSNK1A1L0.45570166
119BMPR20.43132433
120ROCK20.43071111
121ERBB40.43065579
122RPS6KA30.42253995
123DYRK1A0.41675102
124PRKACB0.41179002
125EEF2K0.40880332
126ILK0.40656642
127LIMK10.40579364
128TGFBR20.40044560
129MAPK40.38444146
130FGFR20.37267710
131EIF2AK30.34428304
132MAPK100.34290209
133FGFR10.28880901
134BRD40.28346409
135RIPK10.27500023

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.62934285
2Cardiac muscle contraction_Homo sapiens_hsa042602.86928926
3Nicotine addiction_Homo sapiens_hsa050332.47112692
4Oxidative phosphorylation_Homo sapiens_hsa001902.43465455
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.34382262
6Propanoate metabolism_Homo sapiens_hsa006402.21967901
7Parkinsons disease_Homo sapiens_hsa050122.16393963
8Phenylalanine metabolism_Homo sapiens_hsa003602.02741582
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99269780
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.94418644
11Dilated cardiomyopathy_Homo sapiens_hsa054141.87477518
12Alzheimers disease_Homo sapiens_hsa050101.86861982
13GABAergic synapse_Homo sapiens_hsa047271.83300485
14Complement and coagulation cascades_Homo sapiens_hsa046101.79995355
15Histidine metabolism_Homo sapiens_hsa003401.77407266
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77375190
17Circadian entrainment_Homo sapiens_hsa047131.74851538
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.74629341
19Olfactory transduction_Homo sapiens_hsa047401.71366167
20Butanoate metabolism_Homo sapiens_hsa006501.68060222
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66533996
22Fatty acid degradation_Homo sapiens_hsa000711.66363787
23Arginine and proline metabolism_Homo sapiens_hsa003301.64939281
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62898906
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.60730737
26Glutamatergic synapse_Homo sapiens_hsa047241.60008419
27Fatty acid metabolism_Homo sapiens_hsa012121.58044165
28Morphine addiction_Homo sapiens_hsa050321.57900731
29Nitrogen metabolism_Homo sapiens_hsa009101.56903483
30Synaptic vesicle cycle_Homo sapiens_hsa047211.55007028
31Salivary secretion_Homo sapiens_hsa049701.49431674
32Gastric acid secretion_Homo sapiens_hsa049711.47945282
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47844471
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46978405
35Long-term potentiation_Homo sapiens_hsa047201.45718526
36Pyruvate metabolism_Homo sapiens_hsa006201.40394422
37Insulin secretion_Homo sapiens_hsa049111.39320324
38Calcium signaling pathway_Homo sapiens_hsa040201.38391582
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36977853
40Huntingtons disease_Homo sapiens_hsa050161.35230271
41Amphetamine addiction_Homo sapiens_hsa050311.32124802
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.32011774
43Taste transduction_Homo sapiens_hsa047421.31465294
44Carbon metabolism_Homo sapiens_hsa012001.30344765
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.27786902
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27534279
47Renin secretion_Homo sapiens_hsa049241.22958516
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22501779
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21982508
50Phototransduction_Homo sapiens_hsa047441.20060386
51Dopaminergic synapse_Homo sapiens_hsa047281.15358343
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10744177
53Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10575974
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08248832
55Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07777600
56Oxytocin signaling pathway_Homo sapiens_hsa049211.07646770
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07045091
58Chemical carcinogenesis_Homo sapiens_hsa052041.05735470
59Retinol metabolism_Homo sapiens_hsa008301.04626366
60Collecting duct acid secretion_Homo sapiens_hsa049661.04377235
61Fatty acid biosynthesis_Homo sapiens_hsa000611.04300520
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03989811
63Cholinergic synapse_Homo sapiens_hsa047251.02357752
64ABC transporters_Homo sapiens_hsa020100.99185969
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.97759366
66Serotonergic synapse_Homo sapiens_hsa047260.97567097
67cAMP signaling pathway_Homo sapiens_hsa040240.95501169
68Bile secretion_Homo sapiens_hsa049760.94829937
69Fatty acid elongation_Homo sapiens_hsa000620.93841625
70PPAR signaling pathway_Homo sapiens_hsa033200.90336100
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89218302
72Arginine biosynthesis_Homo sapiens_hsa002200.88775578
73Long-term depression_Homo sapiens_hsa047300.86331611
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82937313
75* Glucagon signaling pathway_Homo sapiens_hsa049220.82197012
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81482922
77Linoleic acid metabolism_Homo sapiens_hsa005910.78768284
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78543904
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78471073
80Cocaine addiction_Homo sapiens_hsa050300.74456383
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73781148
82Type II diabetes mellitus_Homo sapiens_hsa049300.70255948
83GnRH signaling pathway_Homo sapiens_hsa049120.69874018
84Gap junction_Homo sapiens_hsa045400.68776036
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.68571164
86Pancreatic secretion_Homo sapiens_hsa049720.64812126
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64064927
88Starch and sucrose metabolism_Homo sapiens_hsa005000.63688413
89Melanogenesis_Homo sapiens_hsa049160.62450278
90Circadian rhythm_Homo sapiens_hsa047100.62136493
91Fat digestion and absorption_Homo sapiens_hsa049750.57804035
92Dorso-ventral axis formation_Homo sapiens_hsa043200.57743604
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.56165088
94Tight junction_Homo sapiens_hsa045300.55584828
95Pentose phosphate pathway_Homo sapiens_hsa000300.55173202
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55067582
97beta-Alanine metabolism_Homo sapiens_hsa004100.54603039
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54029269
99Sulfur metabolism_Homo sapiens_hsa009200.53897742
100Caffeine metabolism_Homo sapiens_hsa002320.53844322
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.51708126
102Ovarian steroidogenesis_Homo sapiens_hsa049130.51370615
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51070369
104* AMPK signaling pathway_Homo sapiens_hsa041520.49153529
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48387126
106Peroxisome_Homo sapiens_hsa041460.48279261
107Thyroid hormone synthesis_Homo sapiens_hsa049180.47857289
108Mineral absorption_Homo sapiens_hsa049780.46198388
109* Insulin signaling pathway_Homo sapiens_hsa049100.45588337
110Biosynthesis of amino acids_Homo sapiens_hsa012300.45291287
111Tryptophan metabolism_Homo sapiens_hsa003800.44919837
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44734718
113Estrogen signaling pathway_Homo sapiens_hsa049150.44344460
114Vitamin digestion and absorption_Homo sapiens_hsa049770.44012320
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.43928688
116Lysine degradation_Homo sapiens_hsa003100.43750014
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41777105
118Sphingolipid metabolism_Homo sapiens_hsa006000.40671131
119Axon guidance_Homo sapiens_hsa043600.39108514
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38344339
121Vibrio cholerae infection_Homo sapiens_hsa051100.37697436
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36091710
123ErbB signaling pathway_Homo sapiens_hsa040120.34535535
124Vitamin B6 metabolism_Homo sapiens_hsa007500.33374290
125Glycerolipid metabolism_Homo sapiens_hsa005610.32687511
126* Insulin resistance_Homo sapiens_hsa049310.31810093
127* Adipocytokine signaling pathway_Homo sapiens_hsa049200.31390533
128Fructose and mannose metabolism_Homo sapiens_hsa000510.28477910
129Tyrosine metabolism_Homo sapiens_hsa003500.27903944
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.27728080
131Glioma_Homo sapiens_hsa052140.26362398

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