PPAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* nucleobase biosynthetic process (GO:0046112)4.92110886
2mitotic metaphase plate congression (GO:0007080)4.88810085
3DNA replication initiation (GO:0006270)4.86776471
4DNA replication checkpoint (GO:0000076)4.80350508
5establishment of integrated proviral latency (GO:0075713)4.76949908
6* purine nucleobase biosynthetic process (GO:0009113)4.61458155
7DNA strand elongation involved in DNA replication (GO:0006271)4.58757790
8ribosome assembly (GO:0042255)4.52843642
9protein localization to kinetochore (GO:0034501)4.47545784
10nuclear pore organization (GO:0006999)4.46607300
11DNA strand elongation (GO:0022616)4.37283469
12ribosome biogenesis (GO:0042254)4.35120141
13DNA unwinding involved in DNA replication (GO:0006268)4.29171114
14formation of translation preinitiation complex (GO:0001731)4.24601895
15telomere maintenance via semi-conservative replication (GO:0032201)4.22498997
16mitotic nuclear envelope disassembly (GO:0007077)4.19784723
17metaphase plate congression (GO:0051310)4.18954738
18nuclear pore complex assembly (GO:0051292)4.18822033
19folic acid-containing compound biosynthetic process (GO:0009396)4.15306273
20maturation of SSU-rRNA (GO:0030490)4.10128651
21DNA replication-dependent nucleosome assembly (GO:0006335)3.98910740
22DNA replication-dependent nucleosome organization (GO:0034723)3.98910740
23regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.95666823
24chromatin remodeling at centromere (GO:0031055)3.94351670
25CENP-A containing nucleosome assembly (GO:0034080)3.93349921
26membrane disassembly (GO:0030397)3.89579730
27nuclear envelope disassembly (GO:0051081)3.89579730
28mitotic sister chromatid cohesion (GO:0007064)3.88645975
29regulation of spindle organization (GO:0090224)3.88199262
30DNA double-strand break processing (GO:0000729)3.87845113
31telomere maintenance via recombination (GO:0000722)3.86319363
32folic acid metabolic process (GO:0046655)3.80493276
33protein localization to chromosome, centromeric region (GO:0071459)3.77629384
34ribonucleoprotein complex biogenesis (GO:0022613)3.73117863
35mitotic recombination (GO:0006312)3.70842786
36* IMP biosynthetic process (GO:0006188)3.68701149
37DNA replication-independent nucleosome organization (GO:0034724)3.68190275
38DNA replication-independent nucleosome assembly (GO:0006336)3.68190275
39regulation of centriole replication (GO:0046599)3.66936891
40non-recombinational repair (GO:0000726)3.63836320
41double-strand break repair via nonhomologous end joining (GO:0006303)3.63836320
42DNA ligation (GO:0006266)3.63389847
43establishment of viral latency (GO:0019043)3.57118185
44rRNA processing (GO:0006364)3.53686940
45DNA deamination (GO:0045006)3.53211046
46telomere maintenance via telomere lengthening (GO:0010833)3.53076383
47kinetochore organization (GO:0051383)3.48965050
48establishment of chromosome localization (GO:0051303)3.48257894
49positive regulation of chromosome segregation (GO:0051984)3.47954385
50histone exchange (GO:0043486)3.45349450
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.44050388
52rRNA metabolic process (GO:0016072)3.43973567
53spliceosomal snRNP assembly (GO:0000387)3.43610859
54rRNA modification (GO:0000154)3.43261341
55DNA topological change (GO:0006265)3.40341991
56ribosomal large subunit biogenesis (GO:0042273)3.38401988
57attachment of spindle microtubules to kinetochore (GO:0008608)3.32631157
58mitotic chromosome condensation (GO:0007076)3.31897283
59L-serine metabolic process (GO:0006563)3.31634208
60negative regulation of DNA-dependent DNA replication (GO:2000104)3.30993578
61proteasome assembly (GO:0043248)3.27939003
62pore complex assembly (GO:0046931)3.26693229
63mitotic sister chromatid segregation (GO:0000070)3.26503942
64replication fork processing (GO:0031297)3.26073593
65kinetochore assembly (GO:0051382)3.24302921
66regulation of sister chromatid segregation (GO:0033045)3.24025054
67regulation of mitotic sister chromatid separation (GO:0010965)3.24025054
68regulation of mitotic sister chromatid segregation (GO:0033047)3.24025054
69maturation of 5.8S rRNA (GO:0000460)3.23100577
70* IMP metabolic process (GO:0046040)3.22773496
71pseudouridine synthesis (GO:0001522)3.22378223
72DNA catabolic process, exonucleolytic (GO:0000738)3.20835451
73regulation of mitotic spindle organization (GO:0060236)3.19517415
74nucleotide-excision repair, DNA gap filling (GO:0006297)3.18486753
75ribosomal small subunit assembly (GO:0000028)3.18084098
76spindle checkpoint (GO:0031577)3.17930520
77regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.16980944
78regulation of mitotic spindle checkpoint (GO:1903504)3.16980944
79heterochromatin organization (GO:0070828)3.14597510
80protein K6-linked ubiquitination (GO:0085020)3.14209116
81regulation of nuclear cell cycle DNA replication (GO:0033262)3.11374090
82mitotic G2/M transition checkpoint (GO:0044818)3.11123421
83regulation of chromosome segregation (GO:0051983)3.10995388
84negative regulation of chromosome segregation (GO:0051985)3.09824163
85transcription-coupled nucleotide-excision repair (GO:0006283)3.09778492
86somatic diversification of immune receptors via somatic mutation (GO:0002566)3.08972206
87somatic hypermutation of immunoglobulin genes (GO:0016446)3.08972206
88tRNA aminoacylation for protein translation (GO:0006418)3.08295329
89ATP-dependent chromatin remodeling (GO:0043044)3.08009270
90DNA duplex unwinding (GO:0032508)3.07864130
91DNA geometric change (GO:0032392)3.07062969
92negative regulation of mitotic sister chromatid separation (GO:2000816)3.06386540
93negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06386540
94negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06386540
95negative regulation of sister chromatid segregation (GO:0033046)3.06386540
96nuclear envelope organization (GO:0006998)3.06170063
97termination of RNA polymerase I transcription (GO:0006363)3.06156483
98amino acid activation (GO:0043038)3.06062056
99tRNA aminoacylation (GO:0043039)3.06062056
100DNA damage response, detection of DNA damage (GO:0042769)3.04776795
101meiotic chromosome segregation (GO:0045132)3.04113638
102regulation of mitotic metaphase/anaphase transition (GO:0030071)3.03914127
103DNA strand renaturation (GO:0000733)3.03826950
104transcription elongation from RNA polymerase I promoter (GO:0006362)3.03455968
105mitotic spindle checkpoint (GO:0071174)3.03317205
106spindle assembly checkpoint (GO:0071173)3.02448732
107negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01964317
108regulation of centrosome cycle (GO:0046605)3.01029093
109mitotic spindle assembly checkpoint (GO:0007094)3.00835609
110mitochondrial RNA metabolic process (GO:0000959)2.98795521
111protein complex localization (GO:0031503)2.98616247
112chromatin assembly or disassembly (GO:0006333)2.97836046
113regulation of double-strand break repair via homologous recombination (GO:0010569)2.96711176
114pre-miRNA processing (GO:0031054)2.96295507
115transcription from RNA polymerase I promoter (GO:0006360)2.96186626
116negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96111301
117regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.96030361
118termination of RNA polymerase II transcription (GO:0006369)2.95951069
119sister chromatid segregation (GO:0000819)2.95823256
120protein localization to chromosome (GO:0034502)2.95817732
121regulation of helicase activity (GO:0051095)2.95330894
122transcription elongation from RNA polymerase III promoter (GO:0006385)2.95186103
123termination of RNA polymerase III transcription (GO:0006386)2.95186103
124anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94673519
125* cell cycle G1/S phase transition (GO:0044843)2.93962612
126* G1/S transition of mitotic cell cycle (GO:0000082)2.93962612
127translational initiation (GO:0006413)2.92848552
128chromosome segregation (GO:0007059)2.91102356
129negative regulation of mitosis (GO:0045839)2.89547581
130maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88990529
131regulation of translational termination (GO:0006449)2.88866138
132regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85858375
133telomere organization (GO:0032200)2.85591954
134telomere maintenance (GO:0000723)2.85294149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.86838733
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.36443575
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.84346855
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.71589187
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45005564
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26396648
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.05863374
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04812089
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92105764
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.89820271
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.86300875
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82568156
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.82402900
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80621816
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76178588
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46274674
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43970841
18AR_21909140_ChIP-Seq_LNCAP_Human2.37402722
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25026050
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24757103
21VDR_23849224_ChIP-Seq_CD4+_Human2.24369354
22XRN2_22483619_ChIP-Seq_HELA_Human2.24245006
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14918565
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09245027
25* E2F1_21310950_ChIP-Seq_MCF-7_Human2.04960892
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02112872
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01160982
28FOXP3_21729870_ChIP-Seq_TREG_Human1.95400062
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94760386
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.92866080
31GABP_19822575_ChIP-Seq_HepG2_Human1.89417041
32DCP1A_22483619_ChIP-Seq_HELA_Human1.88436067
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88358684
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88106660
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.80483646
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75390815
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72062544
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71143533
39TTF2_22483619_ChIP-Seq_HELA_Human1.70249869
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64284995
41ELK1_19687146_ChIP-ChIP_HELA_Human1.64233874
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62095150
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59625673
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58660486
45KDM5A_27292631_Chip-Seq_BREAST_Human1.53106488
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53099597
47EWS_26573619_Chip-Seq_HEK293_Human1.50728549
48CIITA_25753668_ChIP-Seq_RAJI_Human1.47741212
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.43781419
50MYC_22102868_ChIP-Seq_BL_Human1.40704091
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40299171
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40154147
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39086928
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38791554
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38686162
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37221184
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37156707
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37071460
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34812125
60NANOG_16153702_ChIP-ChIP_HESCs_Human1.33595016
61FUS_26573619_Chip-Seq_HEK293_Human1.30581188
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.30427766
63* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29527482
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29351076
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28589359
66SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28174964
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.26861680
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25351560
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25186014
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23332758
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18345179
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17436793
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.17390116
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14175895
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13002189
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.12654187
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11373678
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10018451
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09824086
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09096254
81TFEB_21752829_ChIP-Seq_HELA_Human1.08377243
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07121420
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06392531
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.06298676
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01253231
86ZNF274_21170338_ChIP-Seq_K562_Hela1.01020215
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00845900
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99510293
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97636847
90SOX17_20123909_ChIP-Seq_XEN_Mouse0.97582111
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96127423
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95977293
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.94529735
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94118375
95MYC_18940864_ChIP-ChIP_HL60_Human0.93306589
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92767639
97VDR_22108803_ChIP-Seq_LS180_Human0.90412925
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90085985
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88401393
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.86386808
101TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85943388
102NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85522777
103IGF1R_20145208_ChIP-Seq_DFB_Human0.84972712
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84158577
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83374340
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83374340
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83374340
108HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82238108
109IRF1_19129219_ChIP-ChIP_H3396_Human0.81250747
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81036872
111FLI1_27457419_Chip-Seq_LIVER_Mouse0.80732717
112POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80163632
113NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79049257
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78162022
115ZNF263_19887448_ChIP-Seq_K562_Human0.77551395
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75848409
117HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.75222107
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.72583829
119CHD1_26751641_Chip-Seq_LNCaP_Human0.70274905
120ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70151967

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.90101431
2MP0010094_abnormal_chromosome_stability4.83208604
3MP0003111_abnormal_nucleus_morphology4.71132194
4MP0004957_abnormal_blastocyst_morpholog4.67993374
5MP0008057_abnormal_DNA_replication4.45586341
6MP0003077_abnormal_cell_cycle4.11174012
7MP0008058_abnormal_DNA_repair3.60259444
8MP0003123_paternal_imprinting2.93082875
9MP0008007_abnormal_cellular_replicative2.72388107
10MP0001730_embryonic_growth_arrest2.67880424
11MP0008932_abnormal_embryonic_tissue2.62904542
12MP0008877_abnormal_DNA_methylation2.52315046
13MP0000350_abnormal_cell_proliferation2.34151649
14MP0002396_abnormal_hematopoietic_system2.31712162
15MP0003786_premature_aging2.24120301
16MP0010307_abnormal_tumor_latency2.23290098
17MP0003718_maternal_effect2.12397123
18MP0005380_embryogenesis_phenotype2.04221498
19MP0001672_abnormal_embryogenesis/_devel2.04221498
20MP0010352_gastrointestinal_tract_polyps2.03997665
21MP0003806_abnormal_nucleotide_metabolis1.99323506
22MP0001697_abnormal_embryo_size1.88122128
23MP0003984_embryonic_growth_retardation1.85751238
24MP0002088_abnormal_embryonic_growth/wei1.80980617
25MP0002080_prenatal_lethality1.73430602
26MP0002938_white_spotting1.60541790
27MP0002085_abnormal_embryonic_tissue1.59457341
28MP0002086_abnormal_extraembryonic_tissu1.58428565
29MP0003567_abnormal_fetal_cardiomyocyte1.57714413
30MP0002084_abnormal_developmental_patter1.56904437
31MP0000490_abnormal_crypts_of1.47714836
32MP0004197_abnormal_fetal_growth/weight/1.47704847
33MP0003890_abnormal_embryonic-extraembry1.43704978
34MP0000313_abnormal_cell_death1.43147716
35MP0001529_abnormal_vocalization1.43010226
36MP0003121_genomic_imprinting1.39583496
37MP0002697_abnormal_eye_size1.34752696
38MP0002210_abnormal_sex_determination1.34402196
39MP0002019_abnormal_tumor_incidence1.33095667
40MP0004808_abnormal_hematopoietic_stem1.29588036
41MP0001188_hyperpigmentation1.29529229
42MP0001293_anophthalmia1.22901889
43MP0006072_abnormal_retinal_apoptosis1.22786531
44MP0001145_abnormal_male_reproductive1.21187832
45MP0009333_abnormal_splenocyte_physiolog1.19461368
46MP0006292_abnormal_olfactory_placode1.17646545
47MP0009672_abnormal_birth_weight1.16450018
48MP0008789_abnormal_olfactory_epithelium1.14773769
49MP0002233_abnormal_nose_morphology1.14092142
50MP0003221_abnormal_cardiomyocyte_apopto1.12983738
51MP0003315_abnormal_perineum_morphology1.08093015
52MP0001929_abnormal_gametogenesis1.07236970
53MP0005076_abnormal_cell_differentiation1.06927720
54MP0000653_abnormal_sex_gland1.05400740
55MP0005394_taste/olfaction_phenotype1.01447120
56MP0005499_abnormal_olfactory_system1.01447120
57MP0004264_abnormal_extraembryonic_tissu1.01437245
58MP0003119_abnormal_digestive_system1.01188918
59MP0002160_abnormal_reproductive_system0.97902191
60MP0005397_hematopoietic_system_phenotyp0.97648100
61MP0001545_abnormal_hematopoietic_system0.97648100
62MP0000647_abnormal_sebaceous_gland0.95212241
63MP0000358_abnormal_cell_content/0.95110362
64MP0002102_abnormal_ear_morphology0.95028415
65MP0003136_yellow_coat_color0.93225736
66MP0002234_abnormal_pharynx_morphology0.89226714
67MP0003861_abnormal_nervous_system0.88655221
68MP0000703_abnormal_thymus_morphology0.87735374
69MP0000579_abnormal_nail_morphology0.87534276
70MP0000049_abnormal_middle_ear0.86683965
71MP0005384_cellular_phenotype0.84400262
72MP0002751_abnormal_autonomic_nervous0.84001537
73MP0003186_abnormal_redox_activity0.82086584
74MP0001119_abnormal_female_reproductive0.82082159
75MP0009703_decreased_birth_body0.81503171
76MP0005389_reproductive_system_phenotype0.80715738
77MP0001177_atelectasis0.80701865
78MP0002009_preneoplasia0.79831773
79MP0003755_abnormal_palate_morphology0.79032566
80MP0005391_vision/eye_phenotype0.77986245
81MP0003937_abnormal_limbs/digits/tail_de0.77727241
82MP0005621_abnormal_cell_physiology0.77372051
83MP0000537_abnormal_urethra_morphology0.77041012
84MP0003698_abnormal_male_reproductive0.76132568
85MP0002722_abnormal_immune_system0.76044863
86MP0006036_abnormal_mitochondrial_physio0.75742291
87MP0002877_abnormal_melanocyte_morpholog0.75053284
88MP0002254_reproductive_system_inflammat0.74528992
89MP0003763_abnormal_thymus_physiology0.73476850
90MP0002111_abnormal_tail_morphology0.72977481
91MP0000689_abnormal_spleen_morphology0.72772649
92MP0005187_abnormal_penis_morphology0.72005580
93MP0000566_synostosis0.70823069
94MP0000428_abnormal_craniofacial_morphol0.70091281
95MP0003941_abnormal_skin_development0.69798105
96MP0002398_abnormal_bone_marrow0.69058045
97MP0010030_abnormal_orbit_morphology0.68096621
98MP0003385_abnormal_body_wall0.67729840
99MP0003935_abnormal_craniofacial_develop0.66836533
100MP0002736_abnormal_nociception_after0.66423935
101MP0001346_abnormal_lacrimal_gland0.65963218
102MP0005253_abnormal_eye_physiology0.65617237
103MP0000631_abnormal_neuroendocrine_gland0.65463248
104MP0000372_irregular_coat_pigmentation0.64792236
105MP0005266_abnormal_metabolism0.64180081
106MP0001661_extended_life_span0.63933578
107MP0002132_abnormal_respiratory_system0.63881624
108MP0001299_abnormal_eye_distance/0.63838710
109MP0006054_spinal_hemorrhage0.63734881
110MP0000432_abnormal_head_morphology0.63663949
111MP0009053_abnormal_anal_canal0.63228137
112MP0001764_abnormal_homeostasis0.63153541
113MP0008995_early_reproductive_senescence0.62028622
114MP0002092_abnormal_eye_morphology0.61997346
115MP0006035_abnormal_mitochondrial_morpho0.60112790
116MP0002090_abnormal_vision0.59788379
117MP0004147_increased_porphyrin_level0.59749197
118MP0003699_abnormal_female_reproductive0.59167906
119MP0001915_intracranial_hemorrhage0.58467998
120MP0005395_other_phenotype0.58350057
121MP0001286_abnormal_eye_development0.57052492
122MP0004084_abnormal_cardiac_muscle0.55677346
123MP0002429_abnormal_blood_cell0.54894229
124MP0008260_abnormal_autophagy0.53154904
125MP0009697_abnormal_copulation0.52216375
126MP0000477_abnormal_intestine_morphology0.52215975
127MP0003936_abnormal_reproductive_system0.50442395
128MP0000598_abnormal_liver_morphology0.50041400
129MP0002269_muscular_atrophy0.49095427
130MP0002127_abnormal_cardiovascular_syste0.48572214
131MP0001919_abnormal_reproductive_system0.48451747
132MP0004133_heterotaxia0.48446541
133MP0003878_abnormal_ear_physiology0.48299455
134MP0005377_hearing/vestibular/ear_phenot0.48299455
135MP0000627_abnormal_mammary_gland0.47730075
136MP0002161_abnormal_fertility/fecundity0.47505684

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.33536890
2Breast hypoplasia (HP:0003187)4.64814811
3Carpal bone hypoplasia (HP:0001498)3.86687525
4Chromsome breakage (HP:0040012)3.76996571
5Patellar aplasia (HP:0006443)3.70906605
6Impulsivity (HP:0100710)3.62310624
7Oral leukoplakia (HP:0002745)3.62309779
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.52115379
9Aplasia/Hypoplasia of the patella (HP:0006498)3.49891097
10Ependymoma (HP:0002888)3.47380531
11Degeneration of anterior horn cells (HP:0002398)3.39098663
12Abnormality of the anterior horn cell (HP:0006802)3.39098663
13Abnormality of chromosome stability (HP:0003220)3.35540418
14Colon cancer (HP:0003003)3.35536195
15Rough bone trabeculation (HP:0100670)3.30559578
16Cerebral hypomyelination (HP:0006808)3.29160065
17Abnormality of the labia minora (HP:0012880)3.25921714
18Reticulocytopenia (HP:0001896)3.23287743
19Abnormality of the preputium (HP:0100587)3.17456683
20Meckel diverticulum (HP:0002245)3.15625619
21Abnormality of cells of the erythroid lineage (HP:0012130)3.12600537
22Medulloblastoma (HP:0002885)3.12250742
23Abnormal number of erythroid precursors (HP:0012131)3.04585113
24Abnormality of the ileum (HP:0001549)2.96979920
25Selective tooth agenesis (HP:0001592)2.94989859
26Aplastic anemia (HP:0001915)2.87547502
27Nephroblastoma (Wilms tumor) (HP:0002667)2.87450617
28Absent radius (HP:0003974)2.85458721
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.82912158
30Embryonal renal neoplasm (HP:0011794)2.81497103
31Rhabdomyosarcoma (HP:0002859)2.70384363
32Agnosia (HP:0010524)2.70172552
33Multiple enchondromatosis (HP:0005701)2.68267425
34Myelodysplasia (HP:0002863)2.67111290
35Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.65132569
36Absent forearm bone (HP:0003953)2.64309978
37Aplasia involving forearm bones (HP:0009822)2.64309978
38Absent thumb (HP:0009777)2.64192232
39Abnormality of methionine metabolism (HP:0010901)2.61322524
40Bone marrow hypocellularity (HP:0005528)2.53063155
41Neoplasm of the pancreas (HP:0002894)2.52326941
42Volvulus (HP:0002580)2.51087789
43Macrocytic anemia (HP:0001972)2.48851641
44Microretrognathia (HP:0000308)2.48771582
45Duodenal stenosis (HP:0100867)2.45595216
46Small intestinal stenosis (HP:0012848)2.45595216
47Megaloblastic anemia (HP:0001889)2.42046651
48Facial hemangioma (HP:0000329)2.41449277
49Cortical dysplasia (HP:0002539)2.41281893
50Increased hepatocellular lipid droplets (HP:0006565)2.41172409
51Horseshoe kidney (HP:0000085)2.40962940
52Premature graying of hair (HP:0002216)2.40905523
53Secondary amenorrhea (HP:0000869)2.40842008
54Abnormal trabecular bone morphology (HP:0100671)2.39198613
55Abnormal spermatogenesis (HP:0008669)2.36756989
56Increased nuchal translucency (HP:0010880)2.34053097
57Progressive muscle weakness (HP:0003323)2.31192760
5811 pairs of ribs (HP:0000878)2.30306492
59Premature ovarian failure (HP:0008209)2.29880892
60Supernumerary spleens (HP:0009799)2.28075763
61Sloping forehead (HP:0000340)2.24789277
62Microvesicular hepatic steatosis (HP:0001414)2.23140195
63Squamous cell carcinoma (HP:0002860)2.22494638
64Abnormality of glycolysis (HP:0004366)2.21648644
65Pancreatic islet-cell hyperplasia (HP:0004510)2.21554255
66Atresia of the external auditory canal (HP:0000413)2.20639960
67Cellular immunodeficiency (HP:0005374)2.20578190
68Basal cell carcinoma (HP:0002671)2.19840902
69Trismus (HP:0000211)2.16861088
70Abnormality of pyrimidine metabolism (HP:0004353)2.16362745
71Ureteral duplication (HP:0000073)2.15785516
72Methylmalonic acidemia (HP:0002912)2.14629176
73Glioma (HP:0009733)2.12672867
74Entropion (HP:0000621)2.12240284
75Abnormality of serum amino acid levels (HP:0003112)2.12135084
76Lipid accumulation in hepatocytes (HP:0006561)2.12111001
77Hypoplasia of the capital femoral epiphysis (HP:0003090)2.11844112
78Prominent nose (HP:0000448)2.10966456
79CNS hypomyelination (HP:0003429)2.10947427
80Increased serum pyruvate (HP:0003542)2.10897837
81Hyperglycinemia (HP:0002154)2.10779768
82Abnormality of the duodenum (HP:0002246)2.09944167
83Proximal placement of thumb (HP:0009623)2.07102807
84Clubbing of toes (HP:0100760)2.07035931
85Irregular epiphyses (HP:0010582)2.06426418
86Deviation of the thumb (HP:0009603)2.03010967
87Abnormality of homocysteine metabolism (HP:0010919)2.02758531
88Homocystinuria (HP:0002156)2.02758531
89Abnormality of the astrocytes (HP:0100707)2.01797932
90Astrocytoma (HP:0009592)2.01797932
91Cafe-au-lait spot (HP:0000957)2.01677749
92Bifid tongue (HP:0010297)2.01625262
93Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01523859
94Tracheoesophageal fistula (HP:0002575)2.01176088
95Abnormal number of incisors (HP:0011064)2.00009266
96Atrophy/Degeneration involving motor neurons (HP:0007373)1.99871585
97Slender long bone (HP:0003100)1.98447100
98Acute encephalopathy (HP:0006846)1.98081387
99Ectopic kidney (HP:0000086)1.96763314
100Biliary tract neoplasm (HP:0100574)1.96321437
101Neoplasm of the colon (HP:0100273)1.96285335
102Missing ribs (HP:0000921)1.94899556
103Aplasia/hypoplasia of the humerus (HP:0006507)1.93156126
104Amaurosis fugax (HP:0100576)1.91208077
105Pallor (HP:0000980)1.91189423
106Spastic diplegia (HP:0001264)1.91137462
107Septo-optic dysplasia (HP:0100842)1.90706582
108Choanal atresia (HP:0000453)1.90270977
109Acute necrotizing encephalopathy (HP:0006965)1.90002847
110Abnormal biliary tract morphology (HP:0012440)1.89231910
111Neoplasm of the oral cavity (HP:0100649)1.88983489
112Facial cleft (HP:0002006)1.88728476
113Glossoptosis (HP:0000162)1.86216609
114Abnormal lung lobation (HP:0002101)1.85624484
115Short thumb (HP:0009778)1.85581749
116Triphalangeal thumb (HP:0001199)1.84586179
117Abnormality of glycine metabolism (HP:0010895)1.84389413
118Abnormality of serine family amino acid metabolism (HP:0010894)1.84389413
119Abnormality of the carotid arteries (HP:0005344)1.83481182
120Neoplasm of striated muscle (HP:0009728)1.82610368
121Lymphoma (HP:0002665)1.81139277
122Abnormality of cochlea (HP:0000375)1.79641310
123Breast aplasia (HP:0100783)1.79265929
124Spinal muscular atrophy (HP:0007269)1.78951628
125Postnatal microcephaly (HP:0005484)1.78915276
126Cleft eyelid (HP:0000625)1.78080729
127Aplasia/Hypoplasia of the sternum (HP:0006714)1.77637897
128Pelvic girdle muscle weakness (HP:0003749)1.76757867
129Pancytopenia (HP:0001876)1.76469323
130Esophageal atresia (HP:0002032)1.76081697
131Hypoplasia of the radius (HP:0002984)1.75807941
132Abnormality of sulfur amino acid metabolism (HP:0004339)1.74216065
133Cerebral edema (HP:0002181)1.73327922
134Increased CSF lactate (HP:0002490)1.73030693
135Hypoplastic pelvis (HP:0008839)1.72335381
136Neoplasm of the adrenal gland (HP:0100631)1.71713068
137Abnormality of the septum pellucidum (HP:0007375)1.70045478
138Type I transferrin isoform profile (HP:0003642)1.69834748
139Intestinal atresia (HP:0011100)1.69389686
140Stenosis of the external auditory canal (HP:0000402)1.69140694
141Aplasia/Hypoplasia of the sacrum (HP:0008517)1.67090912
142Increased serum lactate (HP:0002151)1.65188909
143Embryonal neoplasm (HP:0002898)1.65071663
144Abnormal mitochondria in muscle tissue (HP:0008316)1.64218718
145Progressive external ophthalmoplegia (HP:0000590)1.63820968
146Arteriovenous malformation (HP:0100026)1.62168336
147Hyperglycinuria (HP:0003108)1.61817286
148Ovarian neoplasm (HP:0100615)1.60939141
149Neoplasm of the adrenal cortex (HP:0100641)1.60890336
150Preaxial hand polydactyly (HP:0001177)1.60729824
151Rectal fistula (HP:0100590)1.58954028
152Rectovaginal fistula (HP:0000143)1.58954028
153Abnormality of alanine metabolism (HP:0010916)1.58851066
154Hyperalaninemia (HP:0003348)1.58851066
155Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.58851066
156Hypoplasia of the pons (HP:0012110)1.57558532
157Bilateral microphthalmos (HP:0007633)1.56992343
158Methylmalonic aciduria (HP:0012120)1.55889631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.96028971
2BUB14.36439419
3CDC74.00885073
4EIF2AK13.36641385
5BRSK23.10840356
6PBK3.03191118
7TSSK62.74875879
8SRPK12.70740478
9NEK22.69509492
10VRK22.58615618
11ACVR1B2.56636728
12EIF2AK32.40029974
13TTK2.32332131
14NEK12.28418495
15PLK42.24308915
16PLK12.12260230
17PLK31.91435007
18EPHA21.86263927
19TAF11.82397743
20NUAK11.81637386
21BRSK11.80871177
22STK161.79762410
23MKNK11.77105809
24TNIK1.76692096
25VRK11.74464932
26PASK1.71285203
27WNK31.71254787
28AURKB1.69279707
29CDK71.66433390
30DYRK31.64698802
31NME21.64047810
32TRIM281.63903321
33CDK121.63619435
34ATR1.62297607
35MKNK21.60748044
36CHEK21.49663146
37ZAK1.46721802
38TLK11.42876691
39RPS6KA41.41995923
40RPS6KB21.39146511
41CDK41.34195609
42CHEK11.32460376
43MAP3K81.29802951
44BMPR1B1.23856112
45AURKA1.22133253
46CCNB11.16721857
47SCYL21.15487446
48TESK21.13357757
49FLT31.08778866
50BCR1.06361967
51STK40.97129874
52STK100.96729382
53STK30.96587432
54ATM0.95475555
55STK38L0.94986119
56AKT30.94247813
57PNCK0.93152547
58CDK20.91775175
59PIM10.89396915
60ALK0.88114089
61ERBB30.85815342
62EEF2K0.85650806
63PLK20.80720474
64CSNK1G10.79735422
65TGFBR10.76343106
66PAK40.75355352
67MELK0.75166168
68CSNK2A20.74411529
69BRD40.72845145
70LATS20.70605486
71PKN20.70341881
72CDK10.65767040
73CSNK2A10.65751239
74STK240.65382607
75PRKCI0.62594986
76ERBB40.61446845
77EIF2AK20.60544653
78PDK40.57871420
79PDK30.57871420
80CLK10.57201405
81MAP2K30.57047233
82PAK10.54199041
83CDK80.53413166
84CDK60.53196972
85DYRK20.52808729
86PIM20.51764265
87MAP3K40.51719578
88CDK30.50721857
89BCKDK0.50346236
90MAP3K100.47074892
91CSNK1E0.46969004
92YES10.46803063
93RPS6KA50.44068349
94CSNK1A1L0.43988417
95MARK30.43605723
96CSNK1G20.42869490
97MTOR0.41558788
98BRAF0.41410056
99MAP3K30.38299609
100IRAK30.37702409
101PRKDC0.35415994
102STK390.35042192
103SMG10.34779198
104LATS10.32738723
105MST40.32491546
106MET0.31056827
107AKT20.30059794
108MAP4K20.29225357
109MAP3K50.28641648
110KDR0.28018302
111FGFR20.26986320
112MAPK140.26275008
113NME10.25323104
114FGFR10.23608396
115PDK20.23333853
116LRRK20.23309120
117TAOK20.23307712
118CDK180.22848697
119CSNK1D0.22727543
120NLK0.22681803
121DAPK10.22615617
122MAP4K10.21632815
123TEC0.21489185
124MAPKAPK50.21125476
125MST1R0.21021310
126OXSR10.20929319
127RAF10.20569824
128RPS6KB10.19823741
129PAK20.17497055
130CSNK1G30.16164089
131MAP3K110.15113967

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.70036358
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.33953486
3Mismatch repair_Homo sapiens_hsa034304.05991549
4RNA polymerase_Homo sapiens_hsa030203.61952263
5RNA transport_Homo sapiens_hsa030133.39675495
6Spliceosome_Homo sapiens_hsa030403.14432842
7Proteasome_Homo sapiens_hsa030502.97427832
8Homologous recombination_Homo sapiens_hsa034402.91590449
9One carbon pool by folate_Homo sapiens_hsa006702.86775094
10Cell cycle_Homo sapiens_hsa041102.82552044
11Nucleotide excision repair_Homo sapiens_hsa034202.77243644
12Ribosome_Homo sapiens_hsa030102.69095136
13Base excision repair_Homo sapiens_hsa034102.65109384
14Pyrimidine metabolism_Homo sapiens_hsa002402.56264844
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.53354833
16Fanconi anemia pathway_Homo sapiens_hsa034602.18761570
17Basal transcription factors_Homo sapiens_hsa030222.05769141
18Non-homologous end-joining_Homo sapiens_hsa034502.04235510
19Vitamin B6 metabolism_Homo sapiens_hsa007501.92856185
20RNA degradation_Homo sapiens_hsa030181.84241338
21mRNA surveillance pathway_Homo sapiens_hsa030151.73388692
22p53 signaling pathway_Homo sapiens_hsa041151.60573588
23Propanoate metabolism_Homo sapiens_hsa006401.58100208
24Steroid biosynthesis_Homo sapiens_hsa001001.51928091
25Folate biosynthesis_Homo sapiens_hsa007901.45432850
26* Purine metabolism_Homo sapiens_hsa002301.38535254
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37107650
28Selenocompound metabolism_Homo sapiens_hsa004501.36041172
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.25026167
30Biosynthesis of amino acids_Homo sapiens_hsa012301.21141163
31Pentose phosphate pathway_Homo sapiens_hsa000301.18585173
32Epstein-Barr virus infection_Homo sapiens_hsa051691.15162799
33Parkinsons disease_Homo sapiens_hsa050121.12888076
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12607312
35Systemic lupus erythematosus_Homo sapiens_hsa053221.11070635
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.09426322
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08493540
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07841881
39Oxidative phosphorylation_Homo sapiens_hsa001901.05509860
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01888041
41Oocyte meiosis_Homo sapiens_hsa041140.95894836
42Protein export_Homo sapiens_hsa030600.95162660
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.91310567
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90617911
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89741170
46Viral carcinogenesis_Homo sapiens_hsa052030.89538454
47Fatty acid elongation_Homo sapiens_hsa000620.89522052
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89355643
49Antigen processing and presentation_Homo sapiens_hsa046120.81482161
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76409516
51Herpes simplex infection_Homo sapiens_hsa051680.76354741
52Sulfur relay system_Homo sapiens_hsa041220.74950208
53Carbon metabolism_Homo sapiens_hsa012000.73548506
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71123988
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69545726
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64169958
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61714738
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60607711
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59760564
60Thyroid cancer_Homo sapiens_hsa052160.58342349
61HTLV-I infection_Homo sapiens_hsa051660.54439355
62Glutathione metabolism_Homo sapiens_hsa004800.50906743
63Butanoate metabolism_Homo sapiens_hsa006500.50574708
64Alzheimers disease_Homo sapiens_hsa050100.49270364
65Fructose and mannose metabolism_Homo sapiens_hsa000510.48617489
66Regulation of autophagy_Homo sapiens_hsa041400.46728817
67Fatty acid metabolism_Homo sapiens_hsa012120.45138274
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44719495
69Small cell lung cancer_Homo sapiens_hsa052220.44689661
70MicroRNAs in cancer_Homo sapiens_hsa052060.42947874
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.42344835
72Hedgehog signaling pathway_Homo sapiens_hsa043400.41607366
73Wnt signaling pathway_Homo sapiens_hsa043100.40541778
74Legionellosis_Homo sapiens_hsa051340.39052056
75Galactose metabolism_Homo sapiens_hsa000520.38680165
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36547199
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34745268
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34286801
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34102100
80Vitamin digestion and absorption_Homo sapiens_hsa049770.33668225
81N-Glycan biosynthesis_Homo sapiens_hsa005100.31725670
82* Metabolic pathways_Homo sapiens_hsa011000.31398233
83Huntingtons disease_Homo sapiens_hsa050160.28739061
84Adherens junction_Homo sapiens_hsa045200.28131499
85Alcoholism_Homo sapiens_hsa050340.27016789
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26892005
87Peroxisome_Homo sapiens_hsa041460.26722823
88TGF-beta signaling pathway_Homo sapiens_hsa043500.24687479
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22793851
90Arginine and proline metabolism_Homo sapiens_hsa003300.22623610
91Sulfur metabolism_Homo sapiens_hsa009200.22285500
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21484300
93Hippo signaling pathway_Homo sapiens_hsa043900.20161940
94beta-Alanine metabolism_Homo sapiens_hsa004100.18475870
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.17635530
96* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17162103
97mTOR signaling pathway_Homo sapiens_hsa041500.16934777
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16930465
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16451123
100Apoptosis_Homo sapiens_hsa042100.16400366
101Renin-angiotensin system_Homo sapiens_hsa046140.15947208
102Tight junction_Homo sapiens_hsa045300.15310202
103Hepatitis B_Homo sapiens_hsa051610.14460245
104HIF-1 signaling pathway_Homo sapiens_hsa040660.14169002
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.13276160
106Fatty acid degradation_Homo sapiens_hsa000710.12811473
107Lysine degradation_Homo sapiens_hsa003100.11351363
108Measles_Homo sapiens_hsa051620.10886756
109Arginine biosynthesis_Homo sapiens_hsa002200.09379983
110Phototransduction_Homo sapiens_hsa047440.08404776
111FoxO signaling pathway_Homo sapiens_hsa040680.08164021
112Nitrogen metabolism_Homo sapiens_hsa009100.07986006
113Colorectal cancer_Homo sapiens_hsa052100.07703112
114Influenza A_Homo sapiens_hsa051640.07168611
115Melanoma_Homo sapiens_hsa052180.07145712
116Prostate cancer_Homo sapiens_hsa052150.06650854
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.06484410
118Primary immunodeficiency_Homo sapiens_hsa053400.05366792
119Basal cell carcinoma_Homo sapiens_hsa052170.05077934
120Olfactory transduction_Homo sapiens_hsa047400.04989102
121Pathways in cancer_Homo sapiens_hsa052000.04909760
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.04792663
123Fatty acid biosynthesis_Homo sapiens_hsa000610.03987529
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.03959667
125Bladder cancer_Homo sapiens_hsa052190.03943524
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.03634217
127Linoleic acid metabolism_Homo sapiens_hsa00591-0.0079350
128Pyruvate metabolism_Homo sapiens_hsa00620-0.0076233
129NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0027553
130Circadian rhythm_Homo sapiens_hsa04710-0.0008912

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