PPATP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.36407577
2translational termination (GO:0006415)7.11354901
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.93727894
4SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.40882580
5cotranslational protein targeting to membrane (GO:0006613)6.36369456
6ribosomal small subunit assembly (GO:0000028)6.34536359
7ATP synthesis coupled proton transport (GO:0015986)6.24897159
8energy coupled proton transport, down electrochemical gradient (GO:0015985)6.24897159
9protein targeting to ER (GO:0045047)6.20947178
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.94192794
11translational elongation (GO:0006414)5.84948035
12protein localization to endoplasmic reticulum (GO:0070972)5.80557059
13establishment of protein localization to mitochondrial membrane (GO:0090151)5.71246525
14cellular protein complex disassembly (GO:0043624)5.62414420
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.61678431
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.24254941
17viral life cycle (GO:0019058)5.17333155
18respiratory electron transport chain (GO:0022904)5.12706682
19electron transport chain (GO:0022900)5.01276523
20translational initiation (GO:0006413)4.94805992
21protein complex disassembly (GO:0043241)4.85595420
22maturation of SSU-rRNA (GO:0030490)4.73283432
23macromolecular complex disassembly (GO:0032984)4.61218798
24protein neddylation (GO:0045116)4.51630959
25ribosomal small subunit biogenesis (GO:0042274)4.48387342
26ribosomal large subunit biogenesis (GO:0042273)4.33344844
27thalamus development (GO:0021794)4.26549456
28protein targeting to membrane (GO:0006612)4.10835429
29regulation of mitochondrial translation (GO:0070129)4.08602471
30somite development (GO:0061053)4.05190823
31chaperone-mediated protein transport (GO:0072321)3.99107996
32translation (GO:0006412)3.98618154
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.91264587
34NADH dehydrogenase complex assembly (GO:0010257)3.91264587
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.91264587
36nuclear-transcribed mRNA catabolic process (GO:0000956)3.88928316
37protein complex biogenesis (GO:0070271)3.86351405
38mitochondrial respiratory chain complex assembly (GO:0033108)3.84292427
39inner mitochondrial membrane organization (GO:0007007)3.78314009
40ATP biosynthetic process (GO:0006754)3.65705759
41mRNA catabolic process (GO:0006402)3.64872774
42oxidative phosphorylation (GO:0006119)3.63958184
43aldehyde catabolic process (GO:0046185)3.57406452
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54025772
45regulation of oxidative phosphorylation (GO:0002082)3.48386352
46spliceosomal complex assembly (GO:0000245)3.48286290
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.47877669
48CENP-A containing nucleosome assembly (GO:0034080)3.41210500
49regulation of non-canonical Wnt signaling pathway (GO:2000050)3.40372429
50purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.37565710
51purine nucleoside triphosphate biosynthetic process (GO:0009145)3.36116270
52transcription elongation from RNA polymerase III promoter (GO:0006385)3.35332810
53termination of RNA polymerase III transcription (GO:0006386)3.35332810
54hydrogen ion transmembrane transport (GO:1902600)3.33133394
55chromatin remodeling at centromere (GO:0031055)3.31744263
56protein K6-linked ubiquitination (GO:0085020)3.30747371
57ether metabolic process (GO:0018904)3.25294640
58RNA catabolic process (GO:0006401)3.23545363
59regulation of cilium movement (GO:0003352)3.20197456
60spliceosomal snRNP assembly (GO:0000387)3.15754935
61serine family amino acid catabolic process (GO:0009071)3.10147389
62germ cell migration (GO:0008354)3.08332891
63proteasome assembly (GO:0043248)3.01965244
64positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.01225720
65purine nucleobase biosynthetic process (GO:0009113)3.00103260
66urogenital system development (GO:0001655)2.98739028
67proton transport (GO:0015992)2.98231642
68establishment of integrated proviral latency (GO:0075713)2.96585234
69intracellular protein transmembrane import (GO:0044743)2.93644779
70regulation of glucocorticoid secretion (GO:2000849)2.91913417
71positive regulation of calcium ion import (GO:0090280)2.91909622
72histone exchange (GO:0043486)2.91008026
73positive regulation of monocyte chemotaxis (GO:0090026)2.90780926
74retinal rod cell development (GO:0046548)2.90650005
75hydrogen transport (GO:0006818)2.90347183
76dopamine transport (GO:0015872)2.89232272
77cellular respiration (GO:0045333)2.88554138
78ribonucleoside triphosphate biosynthetic process (GO:0009201)2.83592449
79sequestering of actin monomers (GO:0042989)2.82661302
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.82129822
81regulation of appetite (GO:0032098)2.79690298
82establishment of protein localization to membrane (GO:0090150)2.77879397
83multicellular organismal aging (GO:0010259)2.74685228
84aerobic respiration (GO:0009060)2.74366583
85nonmotile primary cilium assembly (GO:0035058)2.74096966
86midbrain development (GO:0030901)2.72350762
87organelle disassembly (GO:1903008)2.70218880
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.70181152
89protein targeting (GO:0006605)2.69598734
90otic vesicle formation (GO:0030916)2.69098311
91regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.68448462
92cullin deneddylation (GO:0010388)2.68336846
93establishment of protein localization to organelle (GO:0072594)2.67366752
94DNA ligation (GO:0006266)2.67127640
95primitive streak formation (GO:0090009)2.66206435
96glucocorticoid biosynthetic process (GO:0006704)2.66178790
97negative regulation of ligase activity (GO:0051352)2.65675085
98negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.65675085
99DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.64721006
100estrogen biosynthetic process (GO:0006703)2.64550803

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EST1_17652178_ChIP-ChIP_JURKAT_Human4.31316989
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.19776842
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.87470671
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.67470916
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.45687735
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.13420144
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.00785768
8CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.84849875
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.73043583
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.67267633
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.61375727
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43921160
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43183374
14ELK1_19687146_ChIP-ChIP_HELA_Human2.40094727
15ZNF274_21170338_ChIP-Seq_K562_Hela2.28834155
16VDR_22108803_ChIP-Seq_LS180_Human2.19358397
17POU5F1_16153702_ChIP-ChIP_HESCs_Human2.10575579
18FUS_26573619_Chip-Seq_HEK293_Human2.04973866
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99866071
20VDR_23849224_ChIP-Seq_CD4+_Human1.95530679
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.91269278
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85002148
23EWS_26573619_Chip-Seq_HEK293_Human1.83692460
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81835523
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81642342
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79395524
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77257673
28TTF2_22483619_ChIP-Seq_HELA_Human1.76679206
29MYC_18940864_ChIP-ChIP_HL60_Human1.70474948
30FOXP3_21729870_ChIP-Seq_TREG_Human1.69934604
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.69447500
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69223207
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65695533
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63881909
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.59960425
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59750944
37XRN2_22483619_ChIP-Seq_HELA_Human1.58494385
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56946632
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55497762
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55386271
41P300_19829295_ChIP-Seq_ESCs_Human1.54802569
42E2F7_22180533_ChIP-Seq_HELA_Human1.54380780
43EZH2_22144423_ChIP-Seq_EOC_Human1.52777750
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50926247
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.50526614
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.46722437
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45311480
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.43537262
49SOX2_16153702_ChIP-ChIP_HESCs_Human1.41795880
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40574323
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39956567
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39954618
53TAF15_26573619_Chip-Seq_HEK293_Human1.38432075
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.37287906
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36624698
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34946098
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27957543
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25218252
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.22389791
60RNF2_27304074_Chip-Seq_NSC_Mouse1.21799915
61AR_21909140_ChIP-Seq_LNCAP_Human1.20602954
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19091434
63DCP1A_22483619_ChIP-Seq_HELA_Human1.18179634
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.16758794
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16093699
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10522880
67HTT_18923047_ChIP-ChIP_STHdh_Human1.10476885
68FOXM1_23109430_ChIP-Seq_U2OS_Human1.08474436
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06712619
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04625929
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02979109
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02837865
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.02091734
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98614591
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95809108
76BCAT_22108803_ChIP-Seq_LS180_Human0.93600734
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93510722
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93510722
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92839740
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92691014
81TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91175996
82PIAS1_25552417_ChIP-Seq_VCAP_Human0.90499599
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90053662
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89774445
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88882686
86SMAD3_21741376_ChIP-Seq_EPCs_Human0.88238771
87HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87595417
88GBX2_23144817_ChIP-Seq_PC3_Human0.86923916
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86473809
90FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85148238
91FOXA1_25329375_ChIP-Seq_VCAP_Human0.85148238
92TP53_22573176_ChIP-Seq_HFKS_Human0.84414368
93EZH2_27304074_Chip-Seq_ESCs_Mouse0.83647293
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.82666533
95NANOG_19829295_ChIP-Seq_ESCs_Human0.82579122
96SOX2_19829295_ChIP-Seq_ESCs_Human0.82579122
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81856945
98SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80620714
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80423836
100ERG_20517297_ChIP-Seq_VCAP_Human0.80001216

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.67147581
2MP0009379_abnormal_foot_pigmentation4.55981633
3MP0006292_abnormal_olfactory_placode4.03890810
4MP0003283_abnormal_digestive_organ3.50134873
5MP0000372_irregular_coat_pigmentation3.20764263
6MP0003011_delayed_dark_adaptation3.09952923
7MP0001529_abnormal_vocalization2.79635242
8MP0006072_abnormal_retinal_apoptosis2.63784393
9MP0002102_abnormal_ear_morphology2.59747099
10MP0003718_maternal_effect2.57520200
11MP0002736_abnormal_nociception_after2.23569868
12MP0003880_abnormal_central_pattern2.18120475
13MP0003806_abnormal_nucleotide_metabolis2.10796917
14MP0003186_abnormal_redox_activity2.03029694
15MP0005253_abnormal_eye_physiology1.97491997
16MP0002638_abnormal_pupillary_reflex1.94945288
17MP0001968_abnormal_touch/_nociception1.87071479
18MP0003567_abnormal_fetal_cardiomyocyte1.79578695
19MP0004142_abnormal_muscle_tone1.78852424
20MP0008995_early_reproductive_senescence1.75451037
21MP0002277_abnormal_respiratory_mucosa1.74431329
22MP0002938_white_spotting1.73737105
23MP0001919_abnormal_reproductive_system1.69007575
24MP0001905_abnormal_dopamine_level1.66329360
25MP0005187_abnormal_penis_morphology1.64478197
26MP0003890_abnormal_embryonic-extraembry1.64009953
27MP0001293_anophthalmia1.63516216
28MP0005646_abnormal_pituitary_gland1.60421528
29MP0001485_abnormal_pinna_reflex1.60349748
30MP0002822_catalepsy1.54134303
31MP0001984_abnormal_olfaction1.48031471
32MP0005551_abnormal_eye_electrophysiolog1.43384187
33MP0003693_abnormal_embryo_hatching1.41283957
34MP0005171_absent_coat_pigmentation1.41116107
35MP0003122_maternal_imprinting1.39466517
36MP0003938_abnormal_ear_development1.38893208
37MP0010030_abnormal_orbit_morphology1.37999767
38MP0002837_dystrophic_cardiac_calcinosis1.35560808
39MP0009278_abnormal_bone_marrow1.30173216
40MP0000049_abnormal_middle_ear1.29588211
41MP0006035_abnormal_mitochondrial_morpho1.28127081
42MP0005389_reproductive_system_phenotype1.28113369
43MP0004742_abnormal_vestibular_system1.27726271
44MP0003786_premature_aging1.24980855
45MP0002095_abnormal_skin_pigmentation1.22589551
46MP0005503_abnormal_tendon_morphology1.21840209
47MP0002233_abnormal_nose_morphology1.20598462
48MP0002282_abnormal_trachea_morphology1.19994988
49MP0000778_abnormal_nervous_system1.17992905
50MP0002090_abnormal_vision1.16722107
51MP0003121_genomic_imprinting1.15395367
52MP0001727_abnormal_embryo_implantation1.15081211
53MP0000569_abnormal_digit_pigmentation1.13981946
54MP0005386_behavior/neurological_phenoty1.13412920
55MP0004924_abnormal_behavior1.13412920
56MP0004134_abnormal_chest_morphology1.12804003
57MP0008875_abnormal_xenobiotic_pharmacok1.10176257
58MP0005391_vision/eye_phenotype1.08354766
59MP0002234_abnormal_pharynx_morphology1.06486418
60MP0000647_abnormal_sebaceous_gland1.05350339
61MP0000749_muscle_degeneration1.04132896
62MP0003315_abnormal_perineum_morphology1.01476131
63MP0005075_abnormal_melanosome_morpholog1.00988150
64MP0008058_abnormal_DNA_repair0.99373247
65MP0003937_abnormal_limbs/digits/tail_de0.97836824
66MP0001764_abnormal_homeostasis0.96862490
67MP0002108_abnormal_muscle_morphology0.95235118
68MP0009046_muscle_twitch0.94489720
69MP0000631_abnormal_neuroendocrine_gland0.93599980
70MP0001963_abnormal_hearing_physiology0.93458244
71MP0005408_hypopigmentation0.93133331
72MP0002557_abnormal_social/conspecific_i0.92293746
73MP0005645_abnormal_hypothalamus_physiol0.91700806
74MP0009697_abnormal_copulation0.91475038
75MP0010094_abnormal_chromosome_stability0.90818860
76MP0001324_abnormal_eye_pigmentation0.89837272
77MP0000026_abnormal_inner_ear0.88090319
78MP0001286_abnormal_eye_development0.87738190
79MP0001502_abnormal_circadian_rhythm0.85283824
80MP0005410_abnormal_fertilization0.84458373
81MP0008932_abnormal_embryonic_tissue0.82195101
82MP0008789_abnormal_olfactory_epithelium0.81646858
83MP0003137_abnormal_impulse_conducting0.80282300
84MP0009745_abnormal_behavioral_response0.78657912
85MP0005195_abnormal_posterior_eye0.78258223
86MP0002111_abnormal_tail_morphology0.77289299
87MP0002751_abnormal_autonomic_nervous0.76758349
88MP0002752_abnormal_somatic_nervous0.75660448
89MP0006276_abnormal_autonomic_nervous0.75239925
90MP0002067_abnormal_sensory_capabilities0.73980872
91MP0000566_synostosis0.73109514
92MP0008872_abnormal_physiological_respon0.72246118
93MP0001486_abnormal_startle_reflex0.71956622
94MP0004885_abnormal_endolymph0.71159938
95MP0008877_abnormal_DNA_methylation0.71059920
96MP0002697_abnormal_eye_size0.70807428
97MP0005636_abnormal_mineral_homeostasis0.70716073
98MP0002184_abnormal_innervation0.68400666
99MP0005395_other_phenotype0.64413388
100MP0002572_abnormal_emotion/affect_behav0.63528198

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.15290499
2Acute necrotizing encephalopathy (HP:0006965)5.08352510
3Abnormal number of erythroid precursors (HP:0012131)4.97648845
4Increased hepatocellular lipid droplets (HP:0006565)4.84120631
5Abnormality of cells of the erythroid lineage (HP:0012130)4.81899269
6Mitochondrial inheritance (HP:0001427)4.58714815
7Acute encephalopathy (HP:0006846)4.38795421
8Lipid accumulation in hepatocytes (HP:0006561)4.38649206
9Progressive macrocephaly (HP:0004481)4.26040896
10Abnormal mitochondria in muscle tissue (HP:0008316)4.24232735
11Hepatocellular necrosis (HP:0001404)4.08812721
12Increased CSF lactate (HP:0002490)3.86138736
13Congenital, generalized hypertrichosis (HP:0004540)3.85367762
14Hypothermia (HP:0002045)3.82463341
15Hepatic necrosis (HP:0002605)3.80649530
16Septo-optic dysplasia (HP:0100842)3.72516460
17Macrocytic anemia (HP:0001972)3.64634491
18Renal Fanconi syndrome (HP:0001994)3.62378435
19Cerebral edema (HP:0002181)3.47102875
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.19522278
21Degeneration of anterior horn cells (HP:0002398)3.08798107
22Abnormality of the anterior horn cell (HP:0006802)3.08798107
23Exertional dyspnea (HP:0002875)3.03355670
24Decreased circulating renin level (HP:0003351)2.93736895
25Respiratory difficulties (HP:0002880)2.78246672
26Hyperglycinemia (HP:0002154)2.70526105
27Partial duplication of thumb phalanx (HP:0009944)2.67352081
28Chromsome breakage (HP:0040012)2.57890847
29Absent thumb (HP:0009777)2.56421089
30Pallor (HP:0000980)2.56117918
31Hyperglycinuria (HP:0003108)2.52174900
32Leukodystrophy (HP:0002415)2.50180962
33Molar tooth sign on MRI (HP:0002419)2.49282725
34Abnormality of midbrain morphology (HP:0002418)2.49282725
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43803282
36Triphalangeal thumb (HP:0001199)2.36714355
37Congenital stationary night blindness (HP:0007642)2.36621598
38Rectovaginal fistula (HP:0000143)2.36010413
39Rectal fistula (HP:0100590)2.36010413
40Optic disc pallor (HP:0000543)2.31676790
41Colon cancer (HP:0003003)2.29995950
42Increased intramyocellular lipid droplets (HP:0012240)2.29123587
43Abnormality of renal resorption (HP:0011038)2.29010175
44Abnormality of the labia minora (HP:0012880)2.23608868
45Absent septum pellucidum (HP:0001331)2.22546651
46Increased serum lactate (HP:0002151)2.21654833
47Spinal muscular atrophy (HP:0007269)2.21333429
48Partial duplication of the phalanx of hand (HP:0009999)2.19080577
49Meckel diverticulum (HP:0002245)2.17119085
50Respiratory failure (HP:0002878)2.16715859
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.16694553
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.16553018
53Exercise intolerance (HP:0003546)2.15747267
54Duplication of thumb phalanx (HP:0009942)2.14869196
55Keratoconus (HP:0000563)2.14034262
56Increased corneal curvature (HP:0100692)2.14034262
57Hyperactive renin-angiotensin system (HP:0000841)2.13430769
583-Methylglutaconic aciduria (HP:0003535)2.09274853
59Abnormal pupillary function (HP:0007686)2.08180189
60Lactic acidosis (HP:0003128)2.06667899
61Abnormality of the ileum (HP:0001549)2.06460081
62Cleft eyelid (HP:0000625)2.05119587
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99530742
64Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99530742
65Lethargy (HP:0001254)1.98931421
66Abnormality of the septum pellucidum (HP:0007375)1.97059147
67Hyperphosphaturia (HP:0003109)1.95764981
68Glycosuria (HP:0003076)1.95582213
69Abnormality of urine glucose concentration (HP:0011016)1.95582213
70Chronic bronchitis (HP:0004469)1.94939909
71Generalized aminoaciduria (HP:0002909)1.94805434
72Medial flaring of the eyebrow (HP:0010747)1.94341897
73Hypokalemic alkalosis (HP:0001949)1.92459532
74Maternal diabetes (HP:0009800)1.91649049
75Methylmalonic acidemia (HP:0002912)1.88608087
76Abnormality of chromosome stability (HP:0003220)1.88491149
77Increased muscle lipid content (HP:0009058)1.87994150
78Vaginal fistula (HP:0004320)1.86811991
79Aplastic anemia (HP:0001915)1.85961604
80Myokymia (HP:0002411)1.85601120
81Woolly hair (HP:0002224)1.81997620
82Growth hormone deficiency (HP:0000824)1.80575077
83Abnormality of glycine metabolism (HP:0010895)1.80260950
84Abnormality of serine family amino acid metabolism (HP:0010894)1.80260950
85Limb dystonia (HP:0002451)1.79495369
86Abnormality of methionine metabolism (HP:0010901)1.79249980
87Aplasia/Hypoplasia of the patella (HP:0006498)1.78098099
88Intestinal fistula (HP:0100819)1.77308780
89Optic nerve hypoplasia (HP:0000609)1.75480694
90Aplasia/Hypoplasia of the sacrum (HP:0008517)1.74884206
91Patellar aplasia (HP:0006443)1.73850938
92Atrophy/Degeneration involving motor neurons (HP:0007373)1.71903484
93Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70209514
94Abnormality of the carotid arteries (HP:0005344)1.69916844
95X-linked dominant inheritance (HP:0001423)1.66881094
96Delayed CNS myelination (HP:0002188)1.65151133
97Disproportionate short-trunk short stature (HP:0003521)1.65074099
98Sclerocornea (HP:0000647)1.64964314
99Abnormal ciliary motility (HP:0012262)1.64603344
100Confusion (HP:0001289)1.64184334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.83811179
2MST43.34988321
3VRK13.06703712
4BUB12.96240733
5WNK32.51124242
6PLK32.33417806
7SRPK12.23467941
8NUAK12.21564292
9NME12.17487323
10EPHA42.08681846
11TLK12.06544153
12CASK1.95123258
13DAPK21.92883350
14BCKDK1.88668455
15WEE11.82911628
16ZAK1.80880937
17BMPR1B1.77561680
18TGFBR11.73574692
19CDC71.72188743
20TAF11.65810304
21DYRK21.64899652
22DMPK1.60775949
23PNCK1.55943944
24PASK1.46350825
25LIMK11.36319097
26FRK1.33832936
27EPHB21.31438383
28TNIK1.28259985
29CDK31.27508367
30MAPK151.27003203
31PRKCG1.21665388
32MKNK11.19208249
33CHEK21.17417665
34MKNK21.15423851
35PINK11.15190398
36TYRO31.12079598
37TGFBR21.10290164
38CDK81.06451243
39INSRR1.02622943
40GRK10.95250958
41PLK40.93816167
42UHMK10.93714003
43NEK10.87884892
44AURKB0.85936654
45ADRBK20.83149806
46TXK0.81288034
47PLK20.80747358
48PTK2B0.79397349
49ILK0.78570482
50MAPK130.76203310
51PLK10.75803825
52PKN10.68831776
53PBK0.67943599
54CSNK2A10.67208338
55TTK0.65085005
56ADRBK10.64675902
57CSNK2A20.64218463
58GRK70.63486524
59AURKA0.62610657
60MAP4K20.62072753
61STK160.61449394
62DAPK30.61394838
63MAP2K60.61325470
64FGFR20.58880665
65NEK20.58589167
66WNK40.57331756
67PRKG10.54655351
68BRSK20.54218030
69STK240.53597615
70MARK10.52706477
71GRK50.52645888
72RPS6KA50.52220300
73TESK10.52014125
74TSSK60.51807175
75PDK20.51323875
76OBSCN0.51211220
77STK40.50910583
78IRAK20.50351830
79IRAK10.50172248
80RPS6KA60.49471408
81CAMK2A0.48821893
82PRKACB0.48173963
83DYRK1B0.48114187
84ACVR1B0.47258255
85CDK190.47185712
86TNK20.47033123
87PRKCE0.45239412
88RPS6KC10.45167196
89RPS6KL10.45167196
90CCNB10.45108536
91OXSR10.44522203
92CSNK1E0.43673416
93PAK30.40562894
94STK38L0.40167747
95STK390.40030372
96PRKACA0.39647457
97ARAF0.39476095
98YES10.39095623
99ATM0.38719150
100CDK11A0.37329166

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.68525803
2Oxidative phosphorylation_Homo sapiens_hsa001905.01671841
3Parkinsons disease_Homo sapiens_hsa050124.28412345
4Proteasome_Homo sapiens_hsa030503.72675904
5Alzheimers disease_Homo sapiens_hsa050103.14740600
6Huntingtons disease_Homo sapiens_hsa050162.96025105
7Protein export_Homo sapiens_hsa030602.76169428
8RNA polymerase_Homo sapiens_hsa030202.72691615
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.66549081
10Homologous recombination_Homo sapiens_hsa034402.42314133
11Cardiac muscle contraction_Homo sapiens_hsa042602.21690202
12Mismatch repair_Homo sapiens_hsa034301.96181933
13Folate biosynthesis_Homo sapiens_hsa007901.95858697
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87360348
15Spliceosome_Homo sapiens_hsa030401.78412923
16DNA replication_Homo sapiens_hsa030301.75279897
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.73275702
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65010300
19Non-homologous end-joining_Homo sapiens_hsa034501.56958401
20RNA degradation_Homo sapiens_hsa030181.33633092
21Nucleotide excision repair_Homo sapiens_hsa034201.30899490
22Basal transcription factors_Homo sapiens_hsa030221.30834418
23Tyrosine metabolism_Homo sapiens_hsa003501.20397442
24Base excision repair_Homo sapiens_hsa034101.17452190
25Fanconi anemia pathway_Homo sapiens_hsa034601.15347443
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13780873
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13510831
28Sulfur relay system_Homo sapiens_hsa041221.06925829
29Pyrimidine metabolism_Homo sapiens_hsa002401.05007827
30Histidine metabolism_Homo sapiens_hsa003401.02275687
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01169611
32Tryptophan metabolism_Homo sapiens_hsa003801.00202213
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97624829
34Purine metabolism_Homo sapiens_hsa002300.95675093
35Cysteine and methionine metabolism_Homo sapiens_hsa002700.95004501
36Maturity onset diabetes of the young_Homo sapiens_hsa049500.94466533
37One carbon pool by folate_Homo sapiens_hsa006700.92792332
38RNA transport_Homo sapiens_hsa030130.90039965
39Pyruvate metabolism_Homo sapiens_hsa006200.86936325
40Taste transduction_Homo sapiens_hsa047420.84157528
41Propanoate metabolism_Homo sapiens_hsa006400.83060869
42Linoleic acid metabolism_Homo sapiens_hsa005910.81693394
43Phenylalanine metabolism_Homo sapiens_hsa003600.80739165
44Metabolic pathways_Homo sapiens_hsa011000.75709456
45Phototransduction_Homo sapiens_hsa047440.73006126
46Olfactory transduction_Homo sapiens_hsa047400.72468097
47Glutathione metabolism_Homo sapiens_hsa004800.72019655
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70971938
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70966499
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70514294
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67851391
52Basal cell carcinoma_Homo sapiens_hsa052170.67127103
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66230659
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65327735
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56947789
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56221247
57Steroid biosynthesis_Homo sapiens_hsa001000.55834473
58Arachidonic acid metabolism_Homo sapiens_hsa005900.54408774
59Retinol metabolism_Homo sapiens_hsa008300.54367124
60Nitrogen metabolism_Homo sapiens_hsa009100.52725920
61Butanoate metabolism_Homo sapiens_hsa006500.52499062
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51989893
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51212571
64Chemical carcinogenesis_Homo sapiens_hsa052040.49896423
65Caffeine metabolism_Homo sapiens_hsa002320.48862094
66Nicotine addiction_Homo sapiens_hsa050330.46377922
67Arginine and proline metabolism_Homo sapiens_hsa003300.45822679
68Rheumatoid arthritis_Homo sapiens_hsa053230.44503327
69Cell cycle_Homo sapiens_hsa041100.43640373
70Sulfur metabolism_Homo sapiens_hsa009200.43227949
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43087410
72Collecting duct acid secretion_Homo sapiens_hsa049660.41622913
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40894156
74Vitamin digestion and absorption_Homo sapiens_hsa049770.40679455
75Selenocompound metabolism_Homo sapiens_hsa004500.39966261
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.39517459
77Systemic lupus erythematosus_Homo sapiens_hsa053220.37497967
78beta-Alanine metabolism_Homo sapiens_hsa004100.35594871
79Peroxisome_Homo sapiens_hsa041460.33875819
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32541027
81Hedgehog signaling pathway_Homo sapiens_hsa043400.31912989
82GABAergic synapse_Homo sapiens_hsa047270.31206763
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.29483206
84Fat digestion and absorption_Homo sapiens_hsa049750.28528266
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28505365
86Fatty acid degradation_Homo sapiens_hsa000710.27218674
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26356887
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25174711
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.24891435
90Primary immunodeficiency_Homo sapiens_hsa053400.21942435
91Alcoholism_Homo sapiens_hsa050340.21733893
92Arginine biosynthesis_Homo sapiens_hsa002200.19311723
93Asthma_Homo sapiens_hsa053100.18958873
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.17153377
95Morphine addiction_Homo sapiens_hsa050320.16581713
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.16262519
97mRNA surveillance pathway_Homo sapiens_hsa030150.16125221
98TGF-beta signaling pathway_Homo sapiens_hsa043500.14757186
99Circadian entrainment_Homo sapiens_hsa047130.14426396
100Ether lipid metabolism_Homo sapiens_hsa005650.14084425

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