PPCDC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.60280348
2ribosomal small subunit assembly (GO:0000028)5.47734805
3positive regulation of gamma-delta T cell activation (GO:0046645)5.13969067
4DNA deamination (GO:0045006)4.70845600
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.49779377
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.47850502
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.47850502
8viral transcription (GO:0019083)4.33083100
9regulation of B cell receptor signaling pathway (GO:0050855)4.29245376
10regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.29013583
11positive regulation of B cell differentiation (GO:0045579)4.22002143
12antigen processing and presentation of endogenous antigen (GO:0019883)4.16077488
13translational termination (GO:0006415)4.11023514
14antigen processing and presentation via MHC class Ib (GO:0002475)4.05567863
15regulation of gamma-delta T cell differentiation (GO:0045586)4.00547721
16positive regulation by symbiont of host defense response (GO:0052509)4.00208792
17modulation by symbiont of host defense response (GO:0052031)4.00208792
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.00208792
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.00208792
20positive regulation by organism of defense response of other organism involved in symbiotic interact4.00208792
21modulation by symbiont of host immune response (GO:0052553)4.00208792
22response to peptidoglycan (GO:0032494)3.97993092
23regulation of B cell differentiation (GO:0045577)3.97541486
24positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.89390081
25translational elongation (GO:0006414)3.74990517
26ribosomal small subunit biogenesis (GO:0042274)3.72734674
27proteasome assembly (GO:0043248)3.66937565
28B cell receptor signaling pathway (GO:0050853)3.65726969
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.63930891
30regulation of gamma-delta T cell activation (GO:0046643)3.57754482
31cotranslational protein targeting to membrane (GO:0006613)3.57120406
32regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.56468533
33ribosomal large subunit biogenesis (GO:0042273)3.56130553
34positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.55961079
35protein targeting to ER (GO:0045047)3.52035363
36regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.48317417
37mature B cell differentiation involved in immune response (GO:0002313)3.39500659
38protein localization to endoplasmic reticulum (GO:0070972)3.38155584
39maturation of SSU-rRNA (GO:0030490)3.35682873
40negative regulation of interleukin-12 production (GO:0032695)3.34200775
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32010980
42establishment of protein localization to endoplasmic reticulum (GO:0072599)3.31796077
43positive thymic T cell selection (GO:0045059)3.24975634
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.23194547
45viral life cycle (GO:0019058)3.20662586
46response to interferon-beta (GO:0035456)3.19702037
47antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.18424836
48defense response to protozoan (GO:0042832)3.18195786
49mast cell activation (GO:0045576)3.16253892
50positive regulation of T cell mediated cytotoxicity (GO:0001916)3.15594085
51leukocyte aggregation (GO:0070486)3.11012913
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.05614202
53cellular protein complex disassembly (GO:0043624)3.04939951
54response to type I interferon (GO:0034340)3.04891331
55negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04118183
56negative regulation of ligase activity (GO:0051352)3.04118183
57mature B cell differentiation (GO:0002335)3.03691261
58telomere maintenance via recombination (GO:0000722)3.02604668
59cellular response to type I interferon (GO:0071357)3.02531799
60type I interferon signaling pathway (GO:0060337)3.02531799
61negative regulation of erythrocyte differentiation (GO:0045647)3.01079744
62positive regulation of chemokine secretion (GO:0090197)3.00930107
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00824348
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99768029
65regulation of T cell mediated cytotoxicity (GO:0001914)2.98515836
66detection of other organism (GO:0098543)2.97884994
67T cell homeostasis (GO:0043029)2.96580097
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95278694
69translational initiation (GO:0006413)2.93747151
70regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.93109292
71response to interleukin-15 (GO:0070672)2.91894010
72response to protozoan (GO:0001562)2.91010966
73immunoglobulin mediated immune response (GO:0016064)2.90740594
74detection of molecule of bacterial origin (GO:0032490)2.90206597
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88730871
76positive regulation of granulocyte differentiation (GO:0030854)2.88019773
77neutrophil activation (GO:0042119)2.87785122
78negative regulation of cell killing (GO:0031342)2.87443454
79negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87443454
80positive regulation of interferon-alpha production (GO:0032727)2.87174109
81negative thymic T cell selection (GO:0045060)2.85966576
82cellular response to interleukin-15 (GO:0071350)2.84607760
83cellular response to interferon-beta (GO:0035458)2.84024306
84negative T cell selection (GO:0043383)2.83477562
85cellular extravasation (GO:0045123)2.82756086
86chaperone-mediated protein transport (GO:0072321)2.81435229
87regulation of interferon-beta biosynthetic process (GO:0045357)2.80542911
88leukocyte migration involved in inflammatory response (GO:0002523)2.78412358
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.78346067
90regulation of interleukin-12 biosynthetic process (GO:0045075)2.77798445
91antigen receptor-mediated signaling pathway (GO:0050851)2.76249000
92detection of bacterium (GO:0016045)2.76058738
93autophagic vacuole fusion (GO:0000046)2.75591563
94tolerance induction (GO:0002507)2.73129641
95transcription elongation from RNA polymerase III promoter (GO:0006385)2.72810369
96termination of RNA polymerase III transcription (GO:0006386)2.72810369
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.72619209
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.72619209
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.72619209
100signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.72473083
101intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.72473083
102response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.72156715
103response to host immune response (GO:0052572)2.72156715
104regulation of T cell receptor signaling pathway (GO:0050856)2.72016942
105Arp2/3 complex-mediated actin nucleation (GO:0034314)2.70513488
106macrophage activation involved in immune response (GO:0002281)2.69089478
107myeloid dendritic cell activation (GO:0001773)2.68691187
108regulation of interferon-alpha production (GO:0032647)2.66721699
109mitotic recombination (GO:0006312)2.66137323
110telomere maintenance via semi-conservative replication (GO:0032201)2.65908057
111detection of external biotic stimulus (GO:0098581)2.65116877
112signal transduction involved in DNA damage checkpoint (GO:0072422)2.64475679
113signal transduction involved in DNA integrity checkpoint (GO:0072401)2.64475679
114positive regulation of mitotic sister chromatid separation (GO:1901970)2.62841519
115positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.62841519
116positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.62841519
117lymph node development (GO:0048535)2.62146470
118platelet dense granule organization (GO:0060155)2.61982166
119regulation of RIG-I signaling pathway (GO:0039535)2.61092954
120B cell mediated immunity (GO:0019724)2.60738978
121positive regulation of macrophage differentiation (GO:0045651)2.60022148
122regulation of cellular amino acid metabolic process (GO:0006521)2.60006139
123transcription-coupled nucleotide-excision repair (GO:0006283)2.59906122
124leukocyte degranulation (GO:0043299)2.58821663
125myeloid cell activation involved in immune response (GO:0002275)2.58808232
126granulocyte activation (GO:0036230)2.58687745
127protein complex disassembly (GO:0043241)2.58526276
128nucleoside salvage (GO:0043174)2.58349005
129negative regulation of B cell mediated immunity (GO:0002713)2.57117554
130negative regulation of immunoglobulin mediated immune response (GO:0002890)2.57117554
131signal transduction involved in cell cycle checkpoint (GO:0072395)2.56242482
132rRNA modification (GO:0000154)2.56164102
133DNA strand elongation involved in DNA replication (GO:0006271)2.55423995
134organelle membrane fusion (GO:0090174)2.55032641
135regulation of mitochondrial translation (GO:0070129)2.54755673
136negative regulation of phagocytosis (GO:0050765)2.54342106
137lymphocyte homeostasis (GO:0002260)2.53017316
138interferon-gamma-mediated signaling pathway (GO:0060333)2.52150457
139response to muramyl dipeptide (GO:0032495)2.52102127
140positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.51854811
141energy coupled proton transport, down electrochemical gradient (GO:0015985)2.50895181
142ATP synthesis coupled proton transport (GO:0015986)2.50895181
143establishment of viral latency (GO:0019043)2.50870295
144positive regulation of ligase activity (GO:0051351)2.50651051
145establishment of integrated proviral latency (GO:0075713)2.50354590
146respiratory burst (GO:0045730)2.49999713
147regulation of type I interferon-mediated signaling pathway (GO:0060338)2.49644603
148G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.49230060
149mast cell degranulation (GO:0043303)2.49200711
150mast cell activation involved in immune response (GO:0002279)2.49200711
151pyrimidine nucleoside salvage (GO:0043097)2.48281732
152pyrimidine-containing compound salvage (GO:0008655)2.48281732
153negative regulation of humoral immune response (GO:0002921)2.48137517
154leukocyte homeostasis (GO:0001776)2.47827114
155macromolecular complex disassembly (GO:0032984)2.46253523
156DNA strand elongation (GO:0022616)2.46172677
157negative regulation of T cell receptor signaling pathway (GO:0050860)2.45358912
158negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.44378871
159iron-sulfur cluster assembly (GO:0016226)2.44144085
160metallo-sulfur cluster assembly (GO:0031163)2.44144085
161positive regulation of antigen processing and presentation (GO:0002579)2.44100732
162regulation of regulatory T cell differentiation (GO:0045589)2.43663879
163response to host (GO:0075136)2.43387237
164response to host defenses (GO:0052200)2.43387237
165response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.43387237
166definitive hemopoiesis (GO:0060216)2.43260391
167translation (GO:0006412)2.42662860
168regulation of mast cell degranulation (GO:0043304)2.42543332
169megakaryocyte development (GO:0035855)2.41682256
170regulation of necroptotic process (GO:0060544)2.41581187
171neutrophil activation involved in immune response (GO:0002283)2.41291631
172response to interferon-alpha (GO:0035455)2.41071133
173protein localization to kinetochore (GO:0034501)2.40430969
174negative regulation of B cell apoptotic process (GO:0002903)2.40229753
175positive regulation of chromosome segregation (GO:0051984)2.40039664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.97471435
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.52827746
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.45655156
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.05694225
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.01682305
6E2F7_22180533_ChIP-Seq_HELA_Human2.99066953
7SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.97107061
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.95358719
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.93643356
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82888927
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.75824176
12FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.72269427
13* SCL_19346495_ChIP-Seq_HPC-7_Human2.67574102
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.66173177
15* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.64551549
16GATA1_22025678_ChIP-Seq_K562_Human2.55379232
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.43199206
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.27980608
19TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.27656868
20* SPI1_23547873_ChIP-Seq_NB4_Human2.26984505
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.22953543
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.22163437
23* MYC_18555785_ChIP-Seq_MESCs_Mouse2.19319100
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.17900993
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.12880518
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11308608
27* VDR_21846776_ChIP-Seq_THP-1_Human2.08511834
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.05352573
29ERG_20887958_ChIP-Seq_HPC-7_Mouse2.04164250
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98097376
31SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.97641870
32* MYC_22102868_ChIP-Seq_BL_Human1.95845217
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.92923200
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.92021329
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.89929792
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86365290
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84567418
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.83838821
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82222533
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81735421
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81083344
42* VDR_23849224_ChIP-Seq_CD4+_Human1.79768796
43MYB_26560356_Chip-Seq_TH2_Human1.78929900
44* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.77633483
45* ETS1_20019798_ChIP-Seq_JURKAT_Human1.77037565
46* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74677408
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.73789223
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72969640
49* RUNX1_22412390_ChIP-Seq_EML_Mouse1.72540916
50MAF_26560356_Chip-Seq_TH1_Human1.70590406
51MYB_26560356_Chip-Seq_TH1_Human1.70494481
52FOXP3_21729870_ChIP-Seq_TREG_Human1.70488879
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66761740
54RUNX_20019798_ChIP-Seq_JUKART_Human1.66618499
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.65974316
56* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.65321728
57* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57829761
58* VDR_24763502_ChIP-Seq_THP-1_Human1.56423022
59UTX_26944678_Chip-Seq_JUKART_Human1.55360360
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54992052
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47540259
62* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47456640
63* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46577010
64* TTF2_22483619_ChIP-Seq_HELA_Human1.46190138
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45006415
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.44664082
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.44428164
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42886438
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38603927
70TFEB_21752829_ChIP-Seq_HELA_Human1.38272587
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37060656
72MAF_26560356_Chip-Seq_TH2_Human1.36745283
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35577436
74* XRN2_22483619_ChIP-Seq_HELA_Human1.34118208
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33803571
76* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31324642
77* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30507785
78CIITA_25753668_ChIP-Seq_RAJI_Human1.29045215
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28996803
80* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27383995
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26331500
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19942186
83GABP_19822575_ChIP-Seq_HepG2_Human1.19729715
84* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18213186
85* SPI1_23127762_ChIP-Seq_K562_Human1.16743190
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16045143
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15777805
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15514673
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15003570
90* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14437976
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11551260
92DCP1A_22483619_ChIP-Seq_HELA_Human1.10327870
93E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10193041
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10167145
95PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10004223
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09933782
97GATA3_27048872_Chip-Seq_THYMUS_Human1.09912626
98E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09229113
99KDM5A_27292631_Chip-Seq_BREAST_Human1.09097022
100* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05461221
101MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04691529
102EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03796924
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03531128
104CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02612191
105ELK1_19687146_ChIP-ChIP_HELA_Human1.02546076
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02358353
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01537157
108* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99491971
109* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99438644
110GATA3_26560356_Chip-Seq_TH2_Human0.99261507
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98654858
112E2F1_21310950_ChIP-Seq_MCF-7_Human0.97227848
113FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.96693220
114CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96588311
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96582667
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96341651
117TCF7_22412390_ChIP-Seq_EML_Mouse0.94709078
118PU_27001747_Chip-Seq_BMDM_Mouse0.93931923
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93431163

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.90630974
2MP0005671_abnormal_response_to3.77448972
3MP0002396_abnormal_hematopoietic_system3.63745730
4MP0000685_abnormal_immune_system3.46615858
5MP0003763_abnormal_thymus_physiology3.16179745
6MP0009785_altered_susceptibility_to2.98404085
7MP0001800_abnormal_humoral_immune2.97358864
8MP0002723_abnormal_immune_serum2.67118089
9MP0005464_abnormal_platelet_physiology2.62762304
10MP0002452_abnormal_antigen_presenting2.60346622
11MP0002420_abnormal_adaptive_immunity2.57371821
12MP0001819_abnormal_immune_cell2.53819813
13MP0005025_abnormal_response_to2.53721591
14MP0002277_abnormal_respiratory_mucosa2.51425319
15MP0005000_abnormal_immune_tolerance2.49942288
16MP0002398_abnormal_bone_marrow2.40331132
17MP0005387_immune_system_phenotype2.39769770
18MP0001790_abnormal_immune_system2.39769770
19MP0003436_decreased_susceptibility_to2.36192248
20MP0003724_increased_susceptibility_to2.35184307
21MP0002419_abnormal_innate_immunity2.32460710
22MP0000689_abnormal_spleen_morphology2.31499106
23MP0002148_abnormal_hypersensitivity_rea2.24293247
24MP0005075_abnormal_melanosome_morpholog2.18265177
25MP0000716_abnormal_immune_system2.17205685
26MP0006082_CNS_inflammation2.13455402
27MP0003191_abnormal_cellular_cholesterol2.11930800
28MP0002722_abnormal_immune_system2.10600268
29MP0008260_abnormal_autophagy2.09016297
30MP0005058_abnormal_lysosome_morphology2.07641880
31MP0003866_abnormal_defecation1.99704354
32MP0009333_abnormal_splenocyte_physiolog1.98289688
33MP0002429_abnormal_blood_cell1.90623031
34MP0003111_abnormal_nucleus_morphology1.83123903
35MP0004808_abnormal_hematopoietic_stem1.78720292
36MP0002405_respiratory_system_inflammati1.78609836
37MP0001873_stomach_inflammation1.78374682
38MP0001853_heart_inflammation1.76148730
39MP0010155_abnormal_intestine_physiology1.74792105
40MP0000465_gastrointestinal_hemorrhage1.69030121
41MP0000703_abnormal_thymus_morphology1.68294414
42MP0001845_abnormal_inflammatory_respons1.67822846
43MP0008469_abnormal_protein_level1.63621365
44MP0005174_abnormal_tail_pigmentation1.57254554
45MP0008058_abnormal_DNA_repair1.54388939
46MP0002166_altered_tumor_susceptibility1.54060000
47MP0004147_increased_porphyrin_level1.44834907
48MP0005451_abnormal_body_composition1.44776456
49MP0005397_hematopoietic_system_phenotyp1.44448593
50MP0001545_abnormal_hematopoietic_system1.44448593
51MP0006035_abnormal_mitochondrial_morpho1.44010342
52MP0003303_peritoneal_inflammation1.43151667
53MP0000490_abnormal_crypts_of1.37345126
54MP0004947_skin_inflammation1.32063669
55MP0008007_abnormal_cellular_replicative1.28098960
56MP0002095_abnormal_skin_pigmentation1.27610848
57MP0001764_abnormal_homeostasis1.27547789
58MP0003172_abnormal_lysosome_physiology1.27124167
59MP0002933_joint_inflammation1.20276079
60MP0003300_gastrointestinal_ulcer1.18565857
61MP0003828_pulmonary_edema1.18349181
62MP0010094_abnormal_chromosome_stability1.17433027
63MP0003195_calcinosis1.16786519
64MP0003693_abnormal_embryo_hatching1.14721704
65MP0001533_abnormal_skeleton_physiology1.14698583
66MP0009379_abnormal_foot_pigmentation1.13527668
67MP0009763_increased_sensitivity_to1.11285888
68MP0002019_abnormal_tumor_incidence1.11208743
69MP0005365_abnormal_bile_salt1.10967555
70MP0002006_tumorigenesis1.06155155
71MP0001986_abnormal_taste_sensitivity1.05743894
72MP0003656_abnormal_erythrocyte_physiolo1.03945850
73MP0009840_abnormal_foam_cell1.03614584
74MP0008875_abnormal_xenobiotic_pharmacok1.03038273
75MP0000858_altered_metastatic_potential0.99306923
76MP0008932_abnormal_embryonic_tissue0.97101316
77MP0000343_altered_response_to0.96104085
78MP0002163_abnormal_gland_morphology0.94807566
79MP0000358_abnormal_cell_content/0.94308085
80MP0009764_decreased_sensitivity_to0.94103412
81MP0003186_abnormal_redox_activity0.93776816
82MP0009765_abnormal_xenobiotic_induced0.93636115
83MP0000350_abnormal_cell_proliferation0.93424109
84MP0000015_abnormal_ear_pigmentation0.90169303
85MP0002132_abnormal_respiratory_system0.88524849
86MP0003077_abnormal_cell_cycle0.88358007
87MP0003806_abnormal_nucleotide_metabolis0.87420273
88MP0004381_abnormal_hair_follicle0.85882699
89MP0005310_abnormal_salivary_gland0.85313419
90MP0001919_abnormal_reproductive_system0.84949492
91MP0008004_abnormal_stomach_pH0.80704341
92MP0000371_diluted_coat_color0.79765353
93MP0006036_abnormal_mitochondrial_physio0.79542694
94MP0000313_abnormal_cell_death0.78579059
95MP0005584_abnormal_enzyme/coenzyme_acti0.78283777
96MP0000566_synostosis0.77490491
97MP0008873_increased_physiological_sensi0.77379656
98MP0000609_abnormal_liver_physiology0.73383579
99MP0005085_abnormal_gallbladder_physiolo0.73351242
100MP0003221_abnormal_cardiomyocyte_apopto0.71338088
101MP0005083_abnormal_biliary_tract0.71288386
102MP0005381_digestive/alimentary_phenotyp0.70929474
103MP0004883_abnormal_blood_vessel0.70591583
104MP0003718_maternal_effect0.70272262
105MP0008057_abnormal_DNA_replication0.69831020
106MP0000598_abnormal_liver_morphology0.69100433
107MP0002254_reproductive_system_inflammat0.68669434
108MP0003075_altered_response_to0.68252445
109MP0002136_abnormal_kidney_physiology0.67664358
110MP0009278_abnormal_bone_marrow0.67077050
111MP0003786_premature_aging0.66918250
112MP0003448_altered_tumor_morphology0.66872121
113MP0005084_abnormal_gallbladder_morpholo0.64692388
114MP0003252_abnormal_bile_duct0.63167271
115MP0009643_abnormal_urine_homeostasis0.62986374
116MP0005408_hypopigmentation0.62960687
117MP0005023_abnormal_wound_healing0.62830209
118MP0005319_abnormal_enzyme/_coenzyme0.62755821
119MP0001851_eye_inflammation0.62450769
120MP0003183_abnormal_peptide_metabolism0.60268740
121MP0004957_abnormal_blastocyst_morpholog0.60195698
122MP0009642_abnormal_blood_homeostasis0.59862161
123MP0005166_decreased_susceptibility_to0.59725006
124MP0001663_abnormal_digestive_system0.57261577

Predicted human phenotypes

RankGene SetZ-score
1Panhypogammaglobulinemia (HP:0003139)4.26425003
2Orchitis (HP:0100796)4.26097025
3Retrobulbar optic neuritis (HP:0100654)4.14215711
4Optic neuritis (HP:0100653)4.14215711
5IgM deficiency (HP:0002850)4.06680980
6Recurrent abscess formation (HP:0002722)3.99377906
7Agammaglobulinemia (HP:0004432)3.83754955
8Aplastic anemia (HP:0001915)3.76481571
9Thrombocytosis (HP:0001894)3.75034634
10Chronic otitis media (HP:0000389)3.75011816
11Elevated erythrocyte sedimentation rate (HP:0003565)3.69350509
12Abnormality of cells of the erythroid lineage (HP:0012130)3.64275043
13Abnormal number of erythroid precursors (HP:0012131)3.56223913
14Recurrent viral infections (HP:0004429)3.47670108
15Vacuolated lymphocytes (HP:0001922)3.47455661
16Recurrent bacterial skin infections (HP:0005406)3.45307732
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.41343898
18Abnormality of T cell physiology (HP:0011840)3.33358032
19Recurrent bronchitis (HP:0002837)3.30159900
20Inflammation of the large intestine (HP:0002037)3.23070300
21Recurrent fungal infections (HP:0002841)3.20720497
22Abnormality of T cells (HP:0002843)3.20094946
23Eczematoid dermatitis (HP:0000976)3.18260448
24Colitis (HP:0002583)3.11563255
25Acute necrotizing encephalopathy (HP:0006965)3.09865300
26Reticulocytopenia (HP:0001896)3.09274971
27Keratoconjunctivitis sicca (HP:0001097)3.06287214
28Gastrointestinal inflammation (HP:0004386)3.05191167
29Recurrent skin infections (HP:0001581)3.02968454
30Progressive muscle weakness (HP:0003323)3.01381841
31Recurrent cutaneous fungal infections (HP:0011370)3.00739046
32Chronic mucocutaneous candidiasis (HP:0002728)3.00739046
33Mitochondrial inheritance (HP:0001427)2.99441083
34Myositis (HP:0100614)2.97756884
35Abnormal mitochondria in muscle tissue (HP:0008316)2.97526062
36Meningitis (HP:0001287)2.91805063
37Lymphopenia (HP:0001888)2.90126227
38Keratoconjunctivitis (HP:0001096)2.86659095
39Severe combined immunodeficiency (HP:0004430)2.86121458
40IgG deficiency (HP:0004315)2.79945659
41Prolonged bleeding time (HP:0003010)2.78674934
42Chronic diarrhea (HP:0002028)2.78231411
43Epistaxis (HP:0000421)2.77351170
44Anorexia (HP:0002039)2.77284908
45Abnormality of cells of the lymphoid lineage (HP:0012140)2.76787263
46B lymphocytopenia (HP:0010976)2.72831522
47Abnormality of B cell number (HP:0010975)2.72831522
48Cellulitis (HP:0100658)2.72505226
49Granulocytopenia (HP:0001913)2.70550707
50T lymphocytopenia (HP:0005403)2.66624839
51Acute encephalopathy (HP:0006846)2.64613969
52Increased CSF lactate (HP:0002490)2.63651110
53Hypoplasia of the thymus (HP:0000778)2.61727089
54Recurrent sinusitis (HP:0011108)2.58197297
55Petechiae (HP:0000967)2.58193912
56Combined immunodeficiency (HP:0005387)2.57942231
57Abnormality of T cell number (HP:0011839)2.57741000
58Gastrointestinal infarctions (HP:0005244)2.55236266
59Hepatocellular necrosis (HP:0001404)2.52710741
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52472208
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52472208
62Gastrointestinal stroma tumor (HP:0100723)2.51799863
63Respiratory difficulties (HP:0002880)2.51313750
64Urticaria (HP:0001025)2.50784334
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.49162463
66Type I transferrin isoform profile (HP:0003642)2.47310848
67Abnormality of the nasal mucosa (HP:0000433)2.47062544
68Nasal polyposis (HP:0100582)2.46154574
69Increased hepatocellular lipid droplets (HP:0006565)2.45221622
70Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.44950407
71Abnormality of macrophages (HP:0004311)2.44684250
72Lymphoma (HP:0002665)2.44537641
73Hypochromic microcytic anemia (HP:0004840)2.44347908
74Macrocytic anemia (HP:0001972)2.43139954
75Progressive macrocephaly (HP:0004481)2.41562346
76Encephalitis (HP:0002383)2.39963788
773-Methylglutaconic aciduria (HP:0003535)2.39438765
78Poikiloderma (HP:0001029)2.34881889
79Pancytopenia (HP:0001876)2.34717737
80Renal Fanconi syndrome (HP:0001994)2.34411161
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.32832977
82Abnormality of eosinophils (HP:0001879)2.32187339
83Hyperalaninemia (HP:0003348)2.32112875
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32112875
85Abnormality of alanine metabolism (HP:0010916)2.32112875
86Stomatitis (HP:0010280)2.31519668
87Eosinophilia (HP:0001880)2.29698545
88Duplicated collecting system (HP:0000081)2.29669152
89Neutropenia (HP:0001875)2.29595637
90Pallor (HP:0000980)2.29002314
91Pustule (HP:0200039)2.28684119
92Lactic acidosis (HP:0003128)2.26397417
93Increased IgM level (HP:0003496)2.25512359
94Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25283322
95Impaired platelet aggregation (HP:0003540)2.25013340
96Abnormal platelet function (HP:0011869)2.25013340
97Thyroid-stimulating hormone excess (HP:0002925)2.24468996
98Hepatic necrosis (HP:0002605)2.22534388
99Hypochromic anemia (HP:0001931)2.20813963
100Increased intramyocellular lipid droplets (HP:0012240)2.20753906
101Arterial thrombosis (HP:0004420)2.19906903
102Purpura (HP:0000979)2.19825791
103Chronic obstructive pulmonary disease (HP:0006510)2.19806174
104Obstructive lung disease (HP:0006536)2.19806174
105Long foot (HP:0001833)2.19369868
106Lipid accumulation in hepatocytes (HP:0006561)2.18430113
107Spontaneous hematomas (HP:0007420)2.18120285
108Entropion (HP:0000621)2.17383981
109Vasculitis (HP:0002633)2.16453206
110Microcytic anemia (HP:0001935)2.16139643
111Recurrent gram-negative bacterial infections (HP:0005420)2.13254375
112Systemic lupus erythematosus (HP:0002725)2.11483937
113Leukocytosis (HP:0001974)2.11432122
114Increased serum lactate (HP:0002151)2.10089959
115Thyroiditis (HP:0100646)2.09384221
116Mediastinal lymphadenopathy (HP:0100721)2.08123299
117Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08002733
118Exercise intolerance (HP:0003546)2.07568358
119Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06363923
120Gangrene (HP:0100758)2.05453242
121Glomerulonephritis (HP:0000099)2.05436186
122Pulmonary fibrosis (HP:0002206)2.05140391
123Abnormality of the renal collecting system (HP:0004742)2.05109246
124Reduced antithrombin III activity (HP:0001976)2.04062415
125Autoimmune hemolytic anemia (HP:0001890)2.03569661
126Hypertensive crisis (HP:0100735)2.02306864
127Microvesicular hepatic steatosis (HP:0001414)2.01658882
128Increased IgE level (HP:0003212)2.01625621
129Exertional dyspnea (HP:0002875)2.00296231
130Polyneuropathy (HP:0001271)1.99781942
131Hemoptysis (HP:0002105)1.97405744
132Oral leukoplakia (HP:0002745)1.97150604
133Generalized aminoaciduria (HP:0002909)1.96246166
134Cleft eyelid (HP:0000625)1.96225068
135Abnormality of the prostate (HP:0008775)1.95308959
136Skin rash (HP:0000988)1.95163937
137Acute hepatic failure (HP:0006554)1.94377216
138Cerebral edema (HP:0002181)1.93694694
139Increased muscle lipid content (HP:0009058)1.92806673
140Increased cerebral lipofuscin (HP:0011813)1.92068212
141Abnormal protein glycosylation (HP:0012346)1.91966207
142Abnormal glycosylation (HP:0012345)1.91966207
143Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91966207
144Abnormal protein N-linked glycosylation (HP:0012347)1.91966207
145IgA deficiency (HP:0002720)1.90304723
146Progressive neurologic deterioration (HP:0002344)1.89755916
147Dry hair (HP:0011359)1.89600132
148Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88938427
149Bronchitis (HP:0012387)1.88846924
150Thoracic kyphosis (HP:0002942)1.88630543
151Hepatosplenomegaly (HP:0001433)1.88271082
152Episodic fever (HP:0001954)1.85203845
153Gingivitis (HP:0000230)1.85176317
154Aplasia/Hypoplasia of the thymus (HP:0010515)1.82218215
155Premature loss of primary teeth (HP:0006323)1.81166143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.33297979
2MKNK24.27111025
3VRK23.65911029
4TAOK23.34837732
5TAOK13.23798758
6KIT3.12221535
7MAP3K112.91208295
8MKNK12.87308939
9MAP3K32.72081182
10ZAP702.67539914
11TXK2.53990382
12MAP2K32.47891885
13CSF1R2.44617930
14TNIK2.35393733
15MAPKAPK32.27857333
16BTK2.23893172
17TEC2.22351320
18IKBKE2.18554165
19TGFBR22.14276276
20FLT32.13969431
21TBK12.12045123
22TYK22.03751856
23BLK2.01475067
24EEF2K1.94919639
25KDR1.87829174
26NME21.86931884
27IRAK41.83692479
28STK161.71227235
29BCKDK1.68993038
30SYK1.63068365
31ITK1.61170300
32NME11.59732882
33NLK1.54899527
34JAK31.52804663
35MAP3K61.52565943
36IKBKB1.48414747
37LCK1.42570886
38EIF2AK31.39596172
39STK101.36077517
40ERN11.35300950
41WEE11.34796554
42LYN1.30190996
43TNK21.28393342
44SMG11.23457927
45PIM21.22520845
46ADRBK21.20096661
47FES1.19387222
48CCNB11.18037213
49MAP2K61.17881679
50MAPK121.17261019
51RPS6KB21.15755543
52ZAK1.14852515
53PDK21.12741042
54FGFR41.10722043
55TAF11.09975571
56MAP3K11.09391005
57GRK61.09090412
58MAPKAPK51.05701994
59TESK21.04183070
60STK41.03743081
61MARK31.03230618
62MAP3K141.01906415
63CDK191.00202643
64TTK0.97794949
65MST40.97786434
66JAK10.96319138
67ABL20.95704929
68EPHB10.95136690
69CSK0.94724175
70MAP3K120.93163040
71MATK0.92822510
72CDC70.92681418
73MAP3K130.91002706
74MUSK0.90587453
75MAP3K50.90256851
76FGR0.90177585
77BUB10.89923854
78PBK0.89522581
79IRAK30.88834987
80PRPF4B0.86095383
81HCK0.86094589
82VRK10.84972541
83RPS6KA40.84962354
84MAP3K80.84291105
85SIK30.83465226
86LRRK20.82577352
87TGFBR10.79361971
88CDK30.77489757
89MAP3K100.77445337
90BRSK20.76398471
91IRAK20.74649238
92TSSK60.74187584
93CHEK20.73544418
94PIM10.71392975
95PAK40.68183422
96PLK30.67623725
97CDK80.67287231
98MAPK150.64289303
99CAMKK20.64260987
100MAP2K70.63001812
101TAOK30.60909954
102GRK70.60526902
103TRPM70.60273584
104MAPK70.59404504
105MAPK110.58527228
106PRKCQ0.54966918
107STK240.54639995
108EIF2AK20.53793739
109DYRK30.52139049
110CLK10.52133079
111MAPK40.51625764
112CSNK1G30.50559189
113ACVR1B0.50032113
114MYLK0.49478803
115PLK40.49380799
116EIF2AK10.49361238
117DAPK10.48384167
118CDK70.47351603
119ALK0.45873978
120PLK10.42250981
121NEK90.41912175
122RIPK40.41479023
123CDK40.41079023
124JAK20.41075772
125MAPKAPK20.40602493
126PASK0.39759564
127IGF1R0.39410152
128TLK10.38797700
129AURKB0.38663415
130ATR0.37656996
131IRAK10.37645580
132NEK10.37557783
133CHUK0.35865466
134CSNK1G10.35160417
135ARAF0.34842533
136AURKA0.34603985
137CSNK2A20.34163481
138RAF10.34028194
139MAP3K70.34017988
140CSNK2A10.33305422
141SRPK10.32468328
142NUAK10.32439918
143BRSK10.31917486
144PRKG20.31868341
145SIK20.31135695

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.01818416
2Ribosome_Homo sapiens_hsa030103.95493699
3DNA replication_Homo sapiens_hsa030303.05386394
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.52749383
5Other glycan degradation_Homo sapiens_hsa005112.49619703
6Oxidative phosphorylation_Homo sapiens_hsa001902.27108003
7Mismatch repair_Homo sapiens_hsa034302.26688637
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.21040134
9Homologous recombination_Homo sapiens_hsa034402.12477632
10Parkinsons disease_Homo sapiens_hsa050122.09884069
11Base excision repair_Homo sapiens_hsa034102.01865757
12Hematopoietic cell lineage_Homo sapiens_hsa046401.97669371
13Antigen processing and presentation_Homo sapiens_hsa046121.94880091
14B cell receptor signaling pathway_Homo sapiens_hsa046621.82960183
15Measles_Homo sapiens_hsa051621.81735753
16Leishmaniasis_Homo sapiens_hsa051401.81560802
17Proteasome_Homo sapiens_hsa030501.81082624
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77030647
19Non-homologous end-joining_Homo sapiens_hsa034501.73280852
20RNA polymerase_Homo sapiens_hsa030201.71579731
21Pyrimidine metabolism_Homo sapiens_hsa002401.69713470
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.66937421
23Staphylococcus aureus infection_Homo sapiens_hsa051501.66400810
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.62537248
25Huntingtons disease_Homo sapiens_hsa050161.60684536
26Herpes simplex infection_Homo sapiens_hsa051681.59164872
27Nucleotide excision repair_Homo sapiens_hsa034201.57416173
28* Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46884883
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44176749
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37469260
31Osteoclast differentiation_Homo sapiens_hsa043801.33682812
32Spliceosome_Homo sapiens_hsa030401.29936867
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24691116
34Fanconi anemia pathway_Homo sapiens_hsa034601.22786542
35Allograft rejection_Homo sapiens_hsa053301.22563424
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21867709
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.21425195
38T cell receptor signaling pathway_Homo sapiens_hsa046601.21233157
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14521155
40Pertussis_Homo sapiens_hsa051331.13640220
41Alzheimers disease_Homo sapiens_hsa050101.12167910
42Protein export_Homo sapiens_hsa030601.12092502
43Legionellosis_Homo sapiens_hsa051341.11763203
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09336983
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08862277
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.08030601
47Autoimmune thyroid disease_Homo sapiens_hsa053201.07776715
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05638762
49Caffeine metabolism_Homo sapiens_hsa002321.04162945
50Cell cycle_Homo sapiens_hsa041101.02282216
51Shigellosis_Homo sapiens_hsa051310.98952622
52Folate biosynthesis_Homo sapiens_hsa007900.98730579
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95645237
54Influenza A_Homo sapiens_hsa051640.94735220
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94305251
56ABC transporters_Homo sapiens_hsa020100.93461860
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90798523
58Basal transcription factors_Homo sapiens_hsa030220.88412075
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88112277
60Epstein-Barr virus infection_Homo sapiens_hsa051690.87985730
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87748236
62RNA degradation_Homo sapiens_hsa030180.86471092
63N-Glycan biosynthesis_Homo sapiens_hsa005100.86043513
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84960217
65Apoptosis_Homo sapiens_hsa042100.83391232
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.83127343
67Lysosome_Homo sapiens_hsa041420.81442655
68Arachidonic acid metabolism_Homo sapiens_hsa005900.80834205
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.80707703
70Selenocompound metabolism_Homo sapiens_hsa004500.78081886
71Purine metabolism_Homo sapiens_hsa002300.77211077
72Pentose phosphate pathway_Homo sapiens_hsa000300.76260418
73Acute myeloid leukemia_Homo sapiens_hsa052210.75947578
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75093408
75Platelet activation_Homo sapiens_hsa046110.72340159
76Tuberculosis_Homo sapiens_hsa051520.70515632
77p53 signaling pathway_Homo sapiens_hsa041150.70274251
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69996173
79Type I diabetes mellitus_Homo sapiens_hsa049400.69671509
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.69585172
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65448112
82Malaria_Homo sapiens_hsa051440.65048941
83One carbon pool by folate_Homo sapiens_hsa006700.64342989
84Chemical carcinogenesis_Homo sapiens_hsa052040.63417386
85Toxoplasmosis_Homo sapiens_hsa051450.61889905
86Regulation of autophagy_Homo sapiens_hsa041400.60023540
87Hepatitis C_Homo sapiens_hsa051600.59809149
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58984544
89RNA transport_Homo sapiens_hsa030130.58631904
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58445167
91Galactose metabolism_Homo sapiens_hsa000520.58235436
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57472249
93Rheumatoid arthritis_Homo sapiens_hsa053230.57175580
94African trypanosomiasis_Homo sapiens_hsa051430.56999948
95TNF signaling pathway_Homo sapiens_hsa046680.54626234
96Viral carcinogenesis_Homo sapiens_hsa052030.54350265
97Hepatitis B_Homo sapiens_hsa051610.53848864
98HTLV-I infection_Homo sapiens_hsa051660.53735500
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51904525
100Complement and coagulation cascades_Homo sapiens_hsa046100.51069451
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49852270
102Sulfur relay system_Homo sapiens_hsa041220.48491995
103Histidine metabolism_Homo sapiens_hsa003400.47878798
104Glutathione metabolism_Homo sapiens_hsa004800.47514550
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46797643
106Phagosome_Homo sapiens_hsa041450.46240785
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45923532
108Salmonella infection_Homo sapiens_hsa051320.45779005
109Chemokine signaling pathway_Homo sapiens_hsa040620.45510907
110Graft-versus-host disease_Homo sapiens_hsa053320.45074252
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.43769817
112Peroxisome_Homo sapiens_hsa041460.43493748
113Fatty acid elongation_Homo sapiens_hsa000620.43032652
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40761442
115Systemic lupus erythematosus_Homo sapiens_hsa053220.40632367
116Carbon metabolism_Homo sapiens_hsa012000.40450112
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40055768
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.38644191
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34773105
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34282724
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32926760
122Non-small cell lung cancer_Homo sapiens_hsa052230.32594899
123* Metabolic pathways_Homo sapiens_hsa011000.32338930
124Fructose and mannose metabolism_Homo sapiens_hsa000510.31875003
125Viral myocarditis_Homo sapiens_hsa054160.31400040
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29550071

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