PPCS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bile acid and bile salt transport (GO:0015721)4.66032563
2DNA deamination (GO:0045006)4.62452851
3glycine metabolic process (GO:0006544)4.40602775
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.29452498
5L-phenylalanine metabolic process (GO:0006558)4.29452498
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.05467791
7L-phenylalanine catabolic process (GO:0006559)4.05467791
8folic acid metabolic process (GO:0046655)3.97627700
9serine family amino acid catabolic process (GO:0009071)3.91464500
10glyoxylate metabolic process (GO:0046487)3.87662662
11serine family amino acid biosynthetic process (GO:0009070)3.83807815
12purine nucleobase biosynthetic process (GO:0009113)3.82730217
13nucleobase biosynthetic process (GO:0046112)3.75569521
14cysteine metabolic process (GO:0006534)3.74296698
15serine family amino acid metabolic process (GO:0009069)3.74159376
16ribosomal small subunit assembly (GO:0000028)3.65256353
17aromatic amino acid family catabolic process (GO:0009074)3.61352235
18regulation of protein glycosylation (GO:0060049)3.59441231
19neutrophil activation involved in immune response (GO:0002283)3.58020657
20sulfur amino acid catabolic process (GO:0000098)3.55687733
21maturation of SSU-rRNA (GO:0030490)3.45932873
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.39530648
23protein neddylation (GO:0045116)3.33127228
24oxidative phosphorylation (GO:0006119)3.31274209
25proteasome assembly (GO:0043248)3.27500037
26folic acid-containing compound biosynthetic process (GO:0009396)3.27280317
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.22523802
28xenobiotic catabolic process (GO:0042178)3.20995365
29tryptophan catabolic process (GO:0006569)3.18512643
30indole-containing compound catabolic process (GO:0042436)3.18512643
31indolalkylamine catabolic process (GO:0046218)3.18512643
32L-serine metabolic process (GO:0006563)3.18394586
33respiratory chain complex IV assembly (GO:0008535)3.15446963
34triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.15413233
35bile acid biosynthetic process (GO:0006699)3.14749222
36deoxyribose phosphate catabolic process (GO:0046386)3.12735324
37autophagic vacuole fusion (GO:0000046)3.12323054
38formation of translation preinitiation complex (GO:0001731)3.12305780
39pteridine-containing compound biosynthetic process (GO:0042559)3.11799051
40cytochrome complex assembly (GO:0017004)3.10596888
41Arp2/3 complex-mediated actin nucleation (GO:0034314)3.09909210
42protein complex biogenesis (GO:0070271)3.09844763
43kynurenine metabolic process (GO:0070189)3.09577321
44respiratory electron transport chain (GO:0022904)3.09227204
45electron transport chain (GO:0022900)3.07303017
46lysine metabolic process (GO:0006553)3.06690673
47lysine catabolic process (GO:0006554)3.06690673
48ATP synthesis coupled proton transport (GO:0015986)3.03547483
49energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03547483
50deoxyribonucleotide catabolic process (GO:0009264)3.02913385
51tryptophan metabolic process (GO:0006568)3.02719602
52amino-acid betaine metabolic process (GO:0006577)3.01768830
53negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.98449738
54rRNA modification (GO:0000154)2.95296194
55immunoglobulin mediated immune response (GO:0016064)2.93058811
56aromatic amino acid family metabolic process (GO:0009072)2.91983269
57cytidine metabolic process (GO:0046087)2.91428754
58cytidine catabolic process (GO:0006216)2.91428754
59cytidine deamination (GO:0009972)2.91428754
60sulfur amino acid biosynthetic process (GO:0000097)2.90896404
61purine nucleotide salvage (GO:0032261)2.90452691
62deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.88342885
63L-methionine salvage (GO:0071267)2.87046152
64L-methionine biosynthetic process (GO:0071265)2.87046152
65amino acid salvage (GO:0043102)2.87046152
66nucleoside salvage (GO:0043174)2.86963422
67pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.86781511
68folic acid-containing compound metabolic process (GO:0006760)2.86209750
69alpha-amino acid catabolic process (GO:1901606)2.86143277
70ribosome biogenesis (GO:0042254)2.83415349
71organelle membrane fusion (GO:0090174)2.82861094
72purine deoxyribonucleotide catabolic process (GO:0009155)2.82233123
73purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.82063994
74folic acid transport (GO:0015884)2.81959297
75pteridine-containing compound metabolic process (GO:0042558)2.81764791
76cellular ketone body metabolic process (GO:0046950)2.80877989
77pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.80836189
78regulation of triglyceride catabolic process (GO:0010896)2.80668316
79homocysteine metabolic process (GO:0050667)2.79560248
80aldehyde catabolic process (GO:0046185)2.78433451
81ribosome assembly (GO:0042255)2.78211195
82ribosomal small subunit biogenesis (GO:0042274)2.78048737
83tetrahydrofolate metabolic process (GO:0046653)2.77939814
84positive regulation of glycoprotein biosynthetic process (GO:0010560)2.77534877
85negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.76026131
86viral transcription (GO:0019083)2.75782248
87mitochondrial respiratory chain complex assembly (GO:0033108)2.75633124
88pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.75546020
89ribonucleoprotein complex biogenesis (GO:0022613)2.74616897
90translational termination (GO:0006415)2.74488206
91response to interferon-beta (GO:0035456)2.72725635
92GPI anchor biosynthetic process (GO:0006506)2.72582531
93ribosomal large subunit biogenesis (GO:0042273)2.71933762
94urea cycle (GO:0000050)2.71826015
95urea metabolic process (GO:0019627)2.71826015
96fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.71446088
97* pantothenate metabolic process (GO:0015939)2.71038088
98deoxyribose phosphate metabolic process (GO:0019692)2.70665786
99cellular amino acid catabolic process (GO:0009063)2.70523053
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.69893831
101regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.68140556
102UMP biosynthetic process (GO:0006222)2.67231127
103pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.67231127
104UMP metabolic process (GO:0046049)2.67231127
105pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.67231127
106actin nucleation (GO:0045010)2.64900051
107alpha-linolenic acid metabolic process (GO:0036109)2.64423811
108sulfur amino acid metabolic process (GO:0000096)2.64081444
109positive regulation of glycoprotein metabolic process (GO:1903020)2.64067304
110translational elongation (GO:0006414)2.63474735
111antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.63416706
112antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.63236997
113urate metabolic process (GO:0046415)2.62938790
114negative regulation of fibrinolysis (GO:0051918)2.62909157
115pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.62418689
116bile acid metabolic process (GO:0008206)2.62409783
117regulation of cellular amino acid metabolic process (GO:0006521)2.61448703
118imidazole-containing compound metabolic process (GO:0052803)2.59511210
119ketone body metabolic process (GO:1902224)2.58659482
120cellular glucuronidation (GO:0052695)2.58497595
121DNA strand elongation involved in DNA replication (GO:0006271)2.57864637
122nitrogen cycle metabolic process (GO:0071941)2.57693574
123branched-chain amino acid catabolic process (GO:0009083)2.57174465
124protein deneddylation (GO:0000338)2.57085698
125valine metabolic process (GO:0006573)2.56897269
126B cell mediated immunity (GO:0019724)2.56506792
127one-carbon metabolic process (GO:0006730)2.56443618
128mitochondrial respiratory chain complex I assembly (GO:0032981)2.55797040
129NADH dehydrogenase complex assembly (GO:0010257)2.55797040
130mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55797040
131cullin deneddylation (GO:0010388)2.55491933
132deoxyribose phosphate biosynthetic process (GO:0046385)2.55445961
1332-deoxyribonucleotide biosynthetic process (GO:0009265)2.55445961
134regulation of mitochondrial translation (GO:0070129)2.55436935
135tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.55330891
136RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.55330891
137high-density lipoprotein particle remodeling (GO:0034375)2.55324183
138deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.55152178
139SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.54677326
140platelet dense granule organization (GO:0060155)2.54335314
141translational initiation (GO:0006413)2.54161907
142positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.53286029
143methionine metabolic process (GO:0006555)2.52180430
144regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.51833540
145regulation of protein activation cascade (GO:2000257)2.51707667
146regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.51363818
147pyrimidine nucleoside catabolic process (GO:0046135)2.51308595
1482-deoxyribonucleotide metabolic process (GO:0009394)2.51138565
149positive regulation of lipoprotein lipase activity (GO:0051006)2.51044190
150positive regulation of triglyceride lipase activity (GO:0061365)2.51044190
151pyrimidine ribonucleoside catabolic process (GO:0046133)2.50979042
152DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.50066219
153translation (GO:0006412)2.49962875
154proline metabolic process (GO:0006560)2.49264212
155branched-chain amino acid metabolic process (GO:0009081)2.46274230
156histamine secretion (GO:0001821)2.44020458
157antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.42428983
158pyrimidine nucleotide catabolic process (GO:0006244)2.42353747
159neutrophil activation (GO:0042119)2.41623275
160signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.36461109
161intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.36461109
162daunorubicin metabolic process (GO:0044597)2.36415825
163polyketide metabolic process (GO:0030638)2.36415825
164doxorubicin metabolic process (GO:0044598)2.36415825
165mitochondrial calcium ion transport (GO:0006851)2.36197260
166antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.34489827
167positive regulation of B cell differentiation (GO:0045579)2.32858110
168signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.32786588
169signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.32786588
170signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.32786588
171regulation of B cell apoptotic process (GO:0002902)2.32134544
172deoxyribonucleotide metabolic process (GO:0009262)2.32017619
173GPI anchor metabolic process (GO:0006505)2.31734413
174cellular response to interferon-beta (GO:0035458)2.31695391
175adenosine metabolic process (GO:0046085)2.30927525
176glutathione derivative metabolic process (GO:1901685)2.30479092
177glutathione derivative biosynthetic process (GO:1901687)2.30479092
178protein maturation by protein folding (GO:0022417)2.29799475
179S-adenosylmethionine metabolic process (GO:0046500)2.29638160
180nucleotide salvage (GO:0043173)2.27727511
181purine deoxyribonucleotide metabolic process (GO:0009151)2.27009245
182establishment of protein localization to mitochondrial membrane (GO:0090151)2.26953002
183negative regulation of acute inflammatory response (GO:0002674)2.25256980
184negative regulation of T cell apoptotic process (GO:0070233)2.24408209
185mannosylation (GO:0097502)2.23226082
186cellular response to zinc ion (GO:0071294)2.22226202
187proton transport (GO:0015992)2.20615831
188ubiquinone biosynthetic process (GO:0006744)2.20437891
189hydrogen transport (GO:0006818)2.20202479

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.47268871
2E2F7_22180533_ChIP-Seq_HELA_Human4.20404590
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.63847086
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.54836754
5* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.94494865
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.87791486
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.84732188
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82623599
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.78041824
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.70145643
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.69689431
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.67922616
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59426774
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.57227435
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.56804637
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.52978083
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.51417465
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49838652
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49008388
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48204362
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37092285
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.31204674
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31044141
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.25138367
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09656222
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07581172
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.05188537
28XRN2_22483619_ChIP-Seq_HELA_Human1.92084959
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91337134
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89621871
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87937234
32* VDR_23849224_ChIP-Seq_CD4+_Human1.86005188
33* SPI1_23547873_ChIP-Seq_NB4_Human1.80979911
34* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80891361
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.79312038
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.76514260
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.75108381
38AR_21909140_ChIP-Seq_LNCAP_Human1.72595707
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.71188787
40DCP1A_22483619_ChIP-Seq_HELA_Human1.70605818
41FOXP3_21729870_ChIP-Seq_TREG_Human1.69493371
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67072915
43* LXR_22158963_ChIP-Seq_LIVER_Mouse1.66071415
44GABP_19822575_ChIP-Seq_HepG2_Human1.64221067
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61328995
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.59163534
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59013996
48HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.55169378
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55026122
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.52083638
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52049689
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51994471
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51133953
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.48947528
55MYB_26560356_Chip-Seq_TH2_Human1.44263066
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44055080
57* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42968048
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42729020
59* GATA3_26560356_Chip-Seq_TH2_Human1.41783357
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39878854
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36603636
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36505690
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31715281
64AR_20517297_ChIP-Seq_VCAP_Human1.31493606
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31053896
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30057362
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.29717705
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27555405
69IRF8_27001747_Chip-Seq_BMDM_Mouse1.27037864
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26669043
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26196974
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25979381
73SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22385335
74TTF2_22483619_ChIP-Seq_HELA_Human1.21936718
75* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20911344
76PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.20723363
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20165467
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19670247
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.17750670
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16627896
81ZNF263_19887448_ChIP-Seq_K562_Human1.16443749
82PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15157988
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15015149
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.14673042
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13682533
86OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13446802
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12970769
88STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12715901
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12684401
90* FOXA1_25329375_ChIP-Seq_VCAP_Human1.12514996
91* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12514996
92SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12313691
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12161045
94MYC_22102868_ChIP-Seq_BL_Human1.11869113
95CIITA_25753668_ChIP-Seq_RAJI_Human1.10168892
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09756189
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.09438547
98* TFEB_21752829_ChIP-Seq_HELA_Human1.08962905
99* KDM5A_27292631_Chip-Seq_BREAST_Human1.08585419
100* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08513296
101TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08288238
102NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07709765
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07015028
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05763482
105GATA3_27048872_Chip-Seq_THYMUS_Human1.04326333
106* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03371204
107STAT1_20625510_ChIP-Seq_HELA_Human1.02527139
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02074501
109PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00895943
110MYB_26560356_Chip-Seq_TH1_Human0.98973838
111NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98572192
112ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97526575
113SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97313144
114ELF5_23300383_ChIP-Seq_T47D_Human0.97054652
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97042195
116MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96320261
117FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96189683
118MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94179047
119SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93565442
120STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93537418
121IGF1R_20145208_ChIP-Seq_DFB_Human0.92406123
122ERG_20517297_ChIP-Seq_VCAP_Human0.92123925
123PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91744810
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91740110
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91495971
126NOTCH1_21737748_ChIP-Seq_TLL_Human0.90637337
127TP53_22573176_ChIP-Seq_HFKS_Human0.89540842
128VDR_22108803_ChIP-Seq_LS180_Human0.89508287
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89490917
130CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88657911
131SCL_19346495_ChIP-Seq_HPC-7_Human0.88569159
132IRF8_22096565_ChIP-ChIP_GC-B_Human0.88476319
133HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87951738
134GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87906988
135HTT_18923047_ChIP-ChIP_STHdh_Human0.87776151
136NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87270393
137ELK1_19687146_ChIP-ChIP_HELA_Human0.87268143
138NANOG_20526341_ChIP-Seq_ESCs_Human0.86757295
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85708278
140MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.85269953
141NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85197598
142IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85168298
143NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85073142
144RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85043361
145* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.84102524
146CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83793064
147ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83135037
148CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82478389
149KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82139029
150POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82062766
151EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81303422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.31839457
2MP0002139_abnormal_hepatobiliary_system5.26943741
3MP0003806_abnormal_nucleotide_metabolis5.09776375
4MP0010234_abnormal_vibrissa_follicle5.04171902
5MP0005085_abnormal_gallbladder_physiolo3.93083521
6MP0005365_abnormal_bile_salt3.80281660
7MP0003693_abnormal_embryo_hatching3.33339730
8MP0008875_abnormal_xenobiotic_pharmacok2.93371033
9MP0003724_increased_susceptibility_to2.81089979
10MP0009840_abnormal_foam_cell2.52055707
11MP0005332_abnormal_amino_acid2.49205570
12MP0002148_abnormal_hypersensitivity_rea2.44575163
13MP0004957_abnormal_blastocyst_morpholog2.35423492
14MP0003186_abnormal_redox_activity2.34584065
15MP0005464_abnormal_platelet_physiology2.30918686
16MP0003252_abnormal_bile_duct2.24306863
17MP0010329_abnormal_lipoprotein_level2.08371950
18MP0002166_altered_tumor_susceptibility1.99954425
19MP0005075_abnormal_melanosome_morpholog1.97661737
20MP0005319_abnormal_enzyme/_coenzyme1.89757288
21MP0010386_abnormal_urinary_bladder1.89509425
22MP0005000_abnormal_immune_tolerance1.85641992
23MP0003191_abnormal_cellular_cholesterol1.83797975
24MP0004019_abnormal_vitamin_homeostasis1.82175817
25MP0005058_abnormal_lysosome_morphology1.80756188
26MP0006036_abnormal_mitochondrial_physio1.79983178
27MP0001764_abnormal_homeostasis1.77688729
28MP0003195_calcinosis1.77478251
29MP0001666_abnormal_nutrient_absorption1.74239245
30MP0003111_abnormal_nucleus_morphology1.73503719
31MP0000372_irregular_coat_pigmentation1.73013929
32MP0006082_CNS_inflammation1.71310077
33MP0003183_abnormal_peptide_metabolism1.70477312
34MP0002723_abnormal_immune_serum1.69038753
35MP0002452_abnormal_antigen_presenting1.68054791
36MP0009643_abnormal_urine_homeostasis1.66168411
37MP0001790_abnormal_immune_system1.64528145
38MP0005387_immune_system_phenotype1.64528145
39MP0002419_abnormal_innate_immunity1.62777905
40MP0005083_abnormal_biliary_tract1.62038557
41MP0000609_abnormal_liver_physiology1.60583662
42MP0003077_abnormal_cell_cycle1.56053925
43MP0008057_abnormal_DNA_replication1.55047543
44MP0002420_abnormal_adaptive_immunity1.50630743
45MP0001819_abnormal_immune_cell1.50429666
46MP0002006_tumorigenesis1.49920417
47MP0010094_abnormal_chromosome_stability1.49537454
48MP0002163_abnormal_gland_morphology1.43160466
49MP0002277_abnormal_respiratory_mucosa1.38356693
50MP0003718_maternal_effect1.34692423
51MP0000465_gastrointestinal_hemorrhage1.34042578
52MP0000604_amyloidosis1.31394225
53MP0000598_abnormal_liver_morphology1.27500207
54MP0005584_abnormal_enzyme/coenzyme_acti1.26761546
55MP0003436_decreased_susceptibility_to1.26741436
56MP0002837_dystrophic_cardiac_calcinosis1.23443265
57MP0009764_decreased_sensitivity_to1.23057322
58MP0003075_altered_response_to1.21550616
59MP0006035_abnormal_mitochondrial_morpho1.18738661
60MP0003787_abnormal_imprinting1.18562673
61MP0002118_abnormal_lipid_homeostasis1.17972979
62MP0005379_endocrine/exocrine_gland_phen1.17428487
63MP0002138_abnormal_hepatobiliary_system1.17032141
64MP0005397_hematopoietic_system_phenotyp1.16451197
65MP0001545_abnormal_hematopoietic_system1.16451197
66MP0001853_heart_inflammation1.15590780
67MP0008058_abnormal_DNA_repair1.15517286
68MP0004147_increased_porphyrin_level1.13374706
69MP0003763_abnormal_thymus_physiology1.12221385
70MP0005636_abnormal_mineral_homeostasis1.11115370
71MP0004264_abnormal_extraembryonic_tissu1.11033889
72MP0000716_abnormal_immune_system1.09982198
73MP0010352_gastrointestinal_tract_polyps1.08785048
74MP0001730_embryonic_growth_arrest1.08348191
75MP0008004_abnormal_stomach_pH1.05935343
76MP0005367_renal/urinary_system_phenotyp1.04753493
77MP0000516_abnormal_urinary_system1.04753493
78MP0001542_abnormal_bone_strength1.04242189
79MP0005166_decreased_susceptibility_to1.03736957
80MP0000490_abnormal_crypts_of1.02858260
81MP0002396_abnormal_hematopoietic_system1.02850898
82MP0002405_respiratory_system_inflammati1.02807257
83MP0003705_abnormal_hypodermis_morpholog1.02255005
84MP0000343_altered_response_to1.00507238
85MP0008469_abnormal_protein_level0.99814277
86MP0009333_abnormal_splenocyte_physiolog0.99731886
87MP0005266_abnormal_metabolism0.98797022
88MP0009697_abnormal_copulation0.98083206
89MP0008932_abnormal_embryonic_tissue0.97509484
90MP0003656_abnormal_erythrocyte_physiolo0.97000206
91MP0003221_abnormal_cardiomyocyte_apopto0.91819698
92MP0002019_abnormal_tumor_incidence0.91385497
93MP0001533_abnormal_skeleton_physiology0.91177594
94MP0008872_abnormal_physiological_respon0.88805662
95MP0005410_abnormal_fertilization0.88360085
96MP0000689_abnormal_spleen_morphology0.88260557
97MP0009785_altered_susceptibility_to0.88160878
98MP0002876_abnormal_thyroid_physiology0.86603591
99MP0005084_abnormal_gallbladder_morpholo0.86422478
100MP0005408_hypopigmentation0.85640221
101MP0002693_abnormal_pancreas_physiology0.85389822
102MP0003172_abnormal_lysosome_physiology0.85361191
103MP0005670_abnormal_white_adipose0.85246057
104MP0004043_abnormal_pH_regulation0.84468177
105MP0001873_stomach_inflammation0.83842521
106MP0005451_abnormal_body_composition0.83692484
107MP0005535_abnormal_body_temperature0.83205417
108MP0001756_abnormal_urination0.82038601
109MP0009642_abnormal_blood_homeostasis0.78113546
110MP0003786_premature_aging0.77823069
111MP0002722_abnormal_immune_system0.77740883
112MP0005671_abnormal_response_to0.77610273
113MP0001835_abnormal_antigen_presentation0.77544774
114MP0008007_abnormal_cellular_replicative0.77536853
115MP0001919_abnormal_reproductive_system0.77054052
116MP0005376_homeostasis/metabolism_phenot0.76624406
117MP0002136_abnormal_kidney_physiology0.75185004
118MP0009763_increased_sensitivity_to0.74865777
119MP0005395_other_phenotype0.74311187
120MP0003866_abnormal_defecation0.73175480
121MP0005023_abnormal_wound_healing0.73105261
122MP0005389_reproductive_system_phenotype0.71602991
123MP0000350_abnormal_cell_proliferation0.70592602
124MP0000477_abnormal_intestine_morphology0.70238320
125MP0000685_abnormal_immune_system0.68081594
126MP0004947_skin_inflammation0.67446566
127MP0005380_embryogenesis_phenotype0.66707402
128MP0001672_abnormal_embryogenesis/_devel0.66707402
129MP0002132_abnormal_respiratory_system0.66404247
130MP0002080_prenatal_lethality0.65953910
131MP0005220_abnormal_exocrine_pancreas0.64629124
132MP0003984_embryonic_growth_retardation0.64301227
133MP0008873_increased_physiological_sensi0.64181374
134MP0010155_abnormal_intestine_physiology0.63859248
135MP0001243_abnormal_dermal_layer0.63249795
136MP0002088_abnormal_embryonic_growth/wei0.63129272
137MP0005025_abnormal_response_to0.60836566
138MP0002398_abnormal_bone_marrow0.60831894
139MP0001697_abnormal_embryo_size0.60616675
140MP0009672_abnormal_birth_weight0.60432490
141MP0002429_abnormal_blood_cell0.59858733
142MP0000358_abnormal_cell_content/0.59429647
143MP0003868_abnormal_feces_composition0.59248524
144MP0001800_abnormal_humoral_immune0.58619794
145MP0001845_abnormal_inflammatory_respons0.58229605
146MP0002086_abnormal_extraembryonic_tissu0.58117515
147MP0003123_paternal_imprinting0.57858682
148MP0003011_delayed_dark_adaptation0.56641744

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.15304432
2Abnormality of monocarboxylic acid metabolism (HP:0010996)4.66157858
3Hypobetalipoproteinemia (HP:0003563)4.41638308
4Hyperglycinuria (HP:0003108)4.26728596
5Intrahepatic cholestasis (HP:0001406)4.25577012
6Hyperglycinemia (HP:0002154)3.97927173
7Hyperammonemia (HP:0001987)3.76966776
8Abnormality of glycine metabolism (HP:0010895)3.66486177
9Abnormality of serine family amino acid metabolism (HP:0010894)3.66486177
10Abnormality of pyrimidine metabolism (HP:0004353)3.63738994
11Xanthomatosis (HP:0000991)3.38091151
12Prolonged partial thromboplastin time (HP:0003645)3.28289170
13Elevated erythrocyte sedimentation rate (HP:0003565)3.27783485
14Abnormality of aspartate family amino acid metabolism (HP:0010899)3.25043944
15Abnormality of fatty-acid metabolism (HP:0004359)3.21398021
16Abnormality of sulfur amino acid metabolism (HP:0004339)3.19862255
17Hypoglycemic coma (HP:0001325)3.19373891
18Deep venous thrombosis (HP:0002625)3.19249241
19Generalized aminoaciduria (HP:0002909)3.10901907
20Lethargy (HP:0001254)3.10373702
21Progressive macrocephaly (HP:0004481)3.09188572
22Dicarboxylic aciduria (HP:0003215)3.08462701
23Abnormality of dicarboxylic acid metabolism (HP:0010995)3.08462701
24Abnormality of methionine metabolism (HP:0010901)3.02300180
25Cerebral edema (HP:0002181)3.01683720
26Hepatic necrosis (HP:0002605)3.01588690
27Oral leukoplakia (HP:0002745)3.00236629
28Abnormality of glutamine family amino acid metabolism (HP:0010902)2.98170668
29Vacuolated lymphocytes (HP:0001922)2.97546278
30Hypolipoproteinemia (HP:0010981)2.92981332
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.85798096
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.85798096
33Increased intramyocellular lipid droplets (HP:0012240)2.85446943
34Gout (HP:0001997)2.85210648
35Lipid accumulation in hepatocytes (HP:0006561)2.84643713
36Abnormality of serum amino acid levels (HP:0003112)2.79540330
37Increased hepatocellular lipid droplets (HP:0006565)2.73840436
38Ketosis (HP:0001946)2.69980618
39Abnormality of the prostate (HP:0008775)2.69375654
40Renal Fanconi syndrome (HP:0001994)2.66405894
41Delayed CNS myelination (HP:0002188)2.65900907
42Type I transferrin isoform profile (HP:0003642)2.63076115
43Hyperlipoproteinemia (HP:0010980)2.61340932
44Fat malabsorption (HP:0002630)2.60693095
45Abnormality of nucleobase metabolism (HP:0010932)2.60512798
46Acute encephalopathy (HP:0006846)2.57913805
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.55616214
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.53932249
49Nausea (HP:0002018)2.53092780
50Multiple enchondromatosis (HP:0005701)2.52673085
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.50849224
52Abnormal protein N-linked glycosylation (HP:0012347)2.50849224
53Abnormal protein glycosylation (HP:0012346)2.50849224
54Abnormal glycosylation (HP:0012345)2.50849224
55Hepatocellular necrosis (HP:0001404)2.48409106
56Abnormality of cells of the erythroid lineage (HP:0012130)2.45914199
57Abnormal number of erythroid precursors (HP:0012131)2.44248931
58Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.43669454
59Petechiae (HP:0000967)2.41818682
60Megaloblastic anemia (HP:0001889)2.41673533
61Stomatitis (HP:0010280)2.41456828
62Reticulocytopenia (HP:0001896)2.40330344
63Colon cancer (HP:0003003)2.38179748
64Metaphyseal dysplasia (HP:0100255)2.37938096
65Proximal tubulopathy (HP:0000114)2.36811530
66Increased serum lactate (HP:0002151)2.36544289
67Macrocytic anemia (HP:0001972)2.33589445
68Birth length less than 3rd percentile (HP:0003561)2.32475826
69Metabolic acidosis (HP:0001942)2.32027623
70Abnormality of the intrinsic pathway (HP:0010989)2.30852541
71Lactic acidosis (HP:0003128)2.29342673
72Cerebral palsy (HP:0100021)2.26574827
73Hyperbilirubinemia (HP:0002904)2.26528574
74Renal cortical cysts (HP:0000803)2.26017817
75Respiratory failure (HP:0002878)2.24551439
76Breast hypoplasia (HP:0003187)2.24246055
77Carpal bone hypoplasia (HP:0001498)2.23955887
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23764171
79Increased CSF lactate (HP:0002490)2.23151355
80Exertional dyspnea (HP:0002875)2.22036783
81Abnormal mitochondria in muscle tissue (HP:0008316)2.21658115
82Severe combined immunodeficiency (HP:0004430)2.19985022
83Increased serum pyruvate (HP:0003542)2.19642303
84Abnormality of glycolysis (HP:0004366)2.19642303
85Autoimmune hemolytic anemia (HP:0001890)2.17880892
86Abnormality of the common coagulation pathway (HP:0010990)2.17694577
87Rough bone trabeculation (HP:0100670)2.16971790
88Aplastic anemia (HP:0001915)2.15874213
89CNS demyelination (HP:0007305)2.15491339
90Abnormality of urine glucose concentration (HP:0011016)2.15199944
91Glycosuria (HP:0003076)2.15199944
923-Methylglutaconic aciduria (HP:0003535)2.14957749
93Acute necrotizing encephalopathy (HP:0006965)2.14757403
94Palpitations (HP:0001962)2.13509179
95Late onset (HP:0003584)2.12824558
96Abnormality of B cell number (HP:0010975)2.12549391
97Abnormality of T cell physiology (HP:0011840)2.11963001
98Recurrent abscess formation (HP:0002722)2.11827441
99Irritability (HP:0000737)2.11810548
100Ragged-red muscle fibers (HP:0003200)2.11417807
101Complement deficiency (HP:0004431)2.10957207
102Abnormality of purine metabolism (HP:0004352)2.08899701
103Hypoalphalipoproteinemia (HP:0003233)2.08231749
104Abnormality of glycolipid metabolism (HP:0010969)2.08187380
105Abnormality of liposaccharide metabolism (HP:0010968)2.08187380
106Abnormality of glycosphingolipid metabolism (HP:0004343)2.08187380
107Steatorrhea (HP:0002570)2.05914947
108Vomiting (HP:0002013)2.04264622
109Mitochondrial inheritance (HP:0001427)2.03981776
110Malnutrition (HP:0004395)2.01421757
111Abnormality of macrophages (HP:0004311)2.00219910
112IgG deficiency (HP:0004315)1.99683967
113Chronic obstructive pulmonary disease (HP:0006510)1.99673929
114Obstructive lung disease (HP:0006536)1.99673929
115Thrombocytosis (HP:0001894)1.97768693
116Thyroiditis (HP:0100646)1.97449407
117Abnormality of renal resorption (HP:0011038)1.96268622
118Joint hemorrhage (HP:0005261)1.94898508
119Increased neuronal autofluorescent lipopigment (HP:0002074)1.94582202
120Recurrent bacterial skin infections (HP:0005406)1.94506400
121Ketoacidosis (HP:0001993)1.93640431
122B lymphocytopenia (HP:0010976)1.93396341
123Exercise intolerance (HP:0003546)1.92369751
124Rhabdomyolysis (HP:0003201)1.92229129
125Pili torti (HP:0003777)1.91917248
126Reduced antithrombin III activity (HP:0001976)1.91711195
127Methylmalonic aciduria (HP:0012120)1.90853535
128Increased muscle lipid content (HP:0009058)1.90645166
129Epidermoid cyst (HP:0200040)1.89764913
130Abnormal cartilage morphology (HP:0002763)1.88678038
131Increased purine levels (HP:0004368)1.86179682
132Hyperuricemia (HP:0002149)1.86179682
133Abolished electroretinogram (ERG) (HP:0000550)1.85453293
134Methylmalonic acidemia (HP:0002912)1.85262493
135Chronic diarrhea (HP:0002028)1.85189648
136Joint swelling (HP:0001386)1.83859376
137Optic disc pallor (HP:0000543)1.83615580
138Progressive neurologic deterioration (HP:0002344)1.83428092
139Abnormality of alanine metabolism (HP:0010916)1.83223717
140Hyperalaninemia (HP:0003348)1.83223717
141Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83223717
142Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83123874
143Abnormality of small intestinal villus morphology (HP:0011472)1.81375004
144Villous atrophy (HP:0011473)1.81375004
145Neonatal onset (HP:0003623)1.79650349
146Eczematoid dermatitis (HP:0000976)1.79207393
147Posterior subcapsular cataract (HP:0007787)1.79012558
148Pancreatitis (HP:0001733)1.77526957
149Spastic diplegia (HP:0001264)1.77461510
150Sparse eyelashes (HP:0000653)1.77176307
151Abnormality of the anterior horn cell (HP:0006802)1.76525028
152Degeneration of anterior horn cells (HP:0002398)1.76525028
153Increased cerebral lipofuscin (HP:0011813)1.76334837
154Increased IgM level (HP:0003496)1.75847510
155Hyperphosphaturia (HP:0003109)1.74946349
156Microcytic anemia (HP:0001935)1.74605773
157Death in infancy (HP:0001522)1.74073266
158Hypoproteinemia (HP:0003075)1.73796044
159Medial flaring of the eyebrow (HP:0010747)1.71404019
160Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70277709
161Abnormal spermatogenesis (HP:0008669)1.69949811
162Hepatosplenomegaly (HP:0001433)1.68726151
163Abnormality of the basal ganglia (HP:0002134)1.68416192
164Granulocytopenia (HP:0001913)1.68321403
165Eosinophilia (HP:0001880)1.67611793
166Skin rash (HP:0000988)1.67005623
167Respiratory difficulties (HP:0002880)1.66302352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.36947836
2BCKDK4.07066818
3MAP3K123.40748569
4WEE13.25233878
5STK163.20899145
6TESK23.20774046
7NME23.10048143
8EIF2AK13.05625264
9PIK3CA2.34537993
10RIPK12.30677784
11SCYL22.22192323
12VRK22.16534444
13TRIM282.06128865
14MAP3K112.05617064
15TAOK31.97275002
16MAP4K21.94034204
17EIF2AK31.83237935
18MAP2K31.81214677
19KDR1.80238872
20EPHA21.79230754
21NUAK11.74130197
22ZAK1.67549357
23MAP4K11.66399203
24FLT31.63646002
25STK101.53995247
26TLK11.51404070
27PLK41.50000143
28MAP3K31.48252856
29MAP2K21.47543667
30ERN11.46553322
31FGFR41.45530425
32RPS6KB21.43845244
33BRSK21.43780127
34CSF1R1.42353651
35BMPR1B1.42085511
36TAOK21.39969965
37MAPKAPK31.39699524
38FRK1.37870419
39NEK11.35583358
40ARAF1.35485087
41BMPR21.34868100
42VRK11.31166021
43ZAP701.24730282
44DYRK31.24336558
45GRK61.21520948
46TTK1.21275806
47NLK1.20277653
48MAP3K81.19680866
49RPS6KA41.18492845
50CDC71.17273479
51GRK11.17089474
52TESK11.16494463
53LMTK21.16397063
54PIM21.14149428
55SIK31.13983606
56ITK1.13381345
57SYK1.13298895
58NEK21.11139508
59PLK11.11012521
60FES1.09391120
61AURKB1.08131621
62RIPK41.06765068
63PRKCQ1.05608505
64ERBB31.04451839
65DAPK11.02396442
66ADRBK21.01922915
67TNK20.98811255
68AURKA0.95905912
69PRKCI0.95203881
70IRAK30.94417077
71MAP3K140.93262132
72SRPK10.92847042
73WNK30.92390729
74PIM10.90510586
75PIK3CG0.89866562
76CDK70.88455618
77TSSK60.87776440
78PASK0.84304888
79OXSR10.82953831
80STK240.82822740
81TYK20.82376780
82CDK40.82198531
83ILK0.82188502
84MAP3K130.81730198
85STK390.81430514
86BCR0.80628756
87PDK30.78778795
88PDK40.78778795
89DAPK30.78742151
90BLK0.78123911
91ACVR1B0.77079077
92TBK10.75490030
93WNK40.74556284
94MYLK0.73843215
95PLK30.69437465
96CHEK20.67316160
97LRRK20.66827961
98AKT30.65934459
99MARK30.65626087
100MAPK110.64901832
101MST40.64349200
102ABL20.64284255
103LCK0.64162390
104BRSK10.63457305
105NME10.61815224
106CSK0.61656945
107FER0.61191363
108CSNK1G30.60597380
109MUSK0.60576857
110PAK40.59990659
111TXK0.59933806
112EIF2AK20.58335329
113CSNK2A20.58033897
114TAOK10.57551055
115ATR0.57313390
116MAP3K50.53769160
117MAP2K70.53728730
118LIMK10.52909032
119CSNK2A10.52775115
120KIT0.51134406
121IKBKB0.51110662
122STK40.50757857
123TEC0.49649134
124BRAF0.48736098
125PKN20.45993305
126PRKCE0.45711458
127MAP2K60.45705691
128CDK190.45264805
129MELK0.44362881
130MATK0.44326190
131ABL10.43999961
132PDK20.43570718
133IKBKE0.42678301
134JAK30.40220792
135BTK0.40076385
136PRKCD0.39634025
137PINK10.39013311
138CSNK1G20.38950068
139RPS6KA50.38485789
140IGF1R0.38470799
141CHUK0.38332802
142PRKG20.37791908
143CAMKK20.37429510
144PBK0.37235745
145DYRK20.37009605
146LYN0.36503386
147CHEK10.35174154
148HCK0.34747805
149ERBB40.34434149
150MAP3K100.34237970
151PTK20.33426691
152DAPK20.33173846
153STK38L0.32833139

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053102.74189516
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.73140245
3Proteasome_Homo sapiens_hsa030502.56311462
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45359774
5Allograft rejection_Homo sapiens_hsa053302.43498419
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40897312
7Ribosome_Homo sapiens_hsa030102.35032189
8Autoimmune thyroid disease_Homo sapiens_hsa053202.34328621
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.28174782
10Type I diabetes mellitus_Homo sapiens_hsa049402.21724624
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.17691502
12DNA replication_Homo sapiens_hsa030302.12717525
13Folate biosynthesis_Homo sapiens_hsa007902.07933393
14Drug metabolism - other enzymes_Homo sapiens_hsa009832.07410212
15Graft-versus-host disease_Homo sapiens_hsa053322.06383046
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96424354
17One carbon pool by folate_Homo sapiens_hsa006701.90993880
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.86429044
19* Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.86033785
20Fatty acid degradation_Homo sapiens_hsa000711.84582556
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83943785
22Selenocompound metabolism_Homo sapiens_hsa004501.79988644
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77774203
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.77644495
25Arginine biosynthesis_Homo sapiens_hsa002201.76233598
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.75695883
27Mismatch repair_Homo sapiens_hsa034301.72471756
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71897673
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.68612343
30Tryptophan metabolism_Homo sapiens_hsa003801.65941188
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63833477
32Peroxisome_Homo sapiens_hsa041461.61586626
33RNA polymerase_Homo sapiens_hsa030201.61338787
34Propanoate metabolism_Homo sapiens_hsa006401.59684122
35Biosynthesis of amino acids_Homo sapiens_hsa012301.59628599
36Pyrimidine metabolism_Homo sapiens_hsa002401.56255258
37Carbon metabolism_Homo sapiens_hsa012001.54444486
38Rheumatoid arthritis_Homo sapiens_hsa053231.52341612
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.49228577
40Nitrogen metabolism_Homo sapiens_hsa009101.41487004
41Pentose phosphate pathway_Homo sapiens_hsa000301.41290292
42Collecting duct acid secretion_Homo sapiens_hsa049661.40731517
43Pyruvate metabolism_Homo sapiens_hsa006201.40370114
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.39028209
45Sulfur relay system_Homo sapiens_hsa041221.38522228
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37274714
47Base excision repair_Homo sapiens_hsa034101.37185145
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34601163
49Chemical carcinogenesis_Homo sapiens_hsa052041.28423758
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.26835667
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.23653312
52Glutathione metabolism_Homo sapiens_hsa004801.22911063
53Complement and coagulation cascades_Homo sapiens_hsa046101.22890094
54beta-Alanine metabolism_Homo sapiens_hsa004101.21503717
55Butanoate metabolism_Homo sapiens_hsa006501.20840312
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20242170
57Vitamin B6 metabolism_Homo sapiens_hsa007501.17898504
58RNA transport_Homo sapiens_hsa030131.17594330
59Fatty acid metabolism_Homo sapiens_hsa012121.16666151
60Bile secretion_Homo sapiens_hsa049761.15223540
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13212179
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13049510
63Histidine metabolism_Homo sapiens_hsa003401.10924631
64Caffeine metabolism_Homo sapiens_hsa002321.09193114
65Spliceosome_Homo sapiens_hsa030401.08238196
66Arachidonic acid metabolism_Homo sapiens_hsa005901.07078674
67Maturity onset diabetes of the young_Homo sapiens_hsa049501.06841902
68Regulation of autophagy_Homo sapiens_hsa041401.05324085
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03715001
70Hematopoietic cell lineage_Homo sapiens_hsa046401.02297154
71PPAR signaling pathway_Homo sapiens_hsa033201.00190011
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99007554
73Nucleotide excision repair_Homo sapiens_hsa034200.98900446
74Sulfur metabolism_Homo sapiens_hsa009200.97363585
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97101651
76Arginine and proline metabolism_Homo sapiens_hsa003300.96035196
77Other glycan degradation_Homo sapiens_hsa005110.95996269
78Phenylalanine metabolism_Homo sapiens_hsa003600.94761715
79Retinol metabolism_Homo sapiens_hsa008300.94476499
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93681217
81Homologous recombination_Homo sapiens_hsa034400.91975314
82Parkinsons disease_Homo sapiens_hsa050120.91408085
83Lysosome_Homo sapiens_hsa041420.91108582
84Starch and sucrose metabolism_Homo sapiens_hsa005000.89208935
85Tyrosine metabolism_Homo sapiens_hsa003500.89163621
86Fructose and mannose metabolism_Homo sapiens_hsa000510.88859284
87Leishmaniasis_Homo sapiens_hsa051400.87796969
88Viral myocarditis_Homo sapiens_hsa054160.86891545
89Fat digestion and absorption_Homo sapiens_hsa049750.84886114
90Vitamin digestion and absorption_Homo sapiens_hsa049770.82151737
91Oxidative phosphorylation_Homo sapiens_hsa001900.81749256
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80094796
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79767371
94Protein export_Homo sapiens_hsa030600.78872266
95Fatty acid elongation_Homo sapiens_hsa000620.78729260
96Galactose metabolism_Homo sapiens_hsa000520.76851913
97* Metabolic pathways_Homo sapiens_hsa011000.76097648
98Linoleic acid metabolism_Homo sapiens_hsa005910.75952022
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75161177
100Primary immunodeficiency_Homo sapiens_hsa053400.75110493
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74670865
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72589973
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72029386
104Cell cycle_Homo sapiens_hsa041100.70844988
105Antigen processing and presentation_Homo sapiens_hsa046120.70474081
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63895504
107Purine metabolism_Homo sapiens_hsa002300.61905094
108p53 signaling pathway_Homo sapiens_hsa041150.61555550
109Phagosome_Homo sapiens_hsa041450.59443913
110Huntingtons disease_Homo sapiens_hsa050160.58679731
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56648578
112N-Glycan biosynthesis_Homo sapiens_hsa005100.53759967
113Glycerolipid metabolism_Homo sapiens_hsa005610.53127307
114Staphylococcus aureus infection_Homo sapiens_hsa051500.49450357
115Herpes simplex infection_Homo sapiens_hsa051680.48797374
116Tuberculosis_Homo sapiens_hsa051520.48636951
117RNA degradation_Homo sapiens_hsa030180.47798899
118Non-homologous end-joining_Homo sapiens_hsa034500.45645114
119Vibrio cholerae infection_Homo sapiens_hsa051100.45070761
120Mineral absorption_Homo sapiens_hsa049780.45024452
121Basal transcription factors_Homo sapiens_hsa030220.41500567
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.41109258
123Legionellosis_Homo sapiens_hsa051340.40459518
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38303696
125Renin-angiotensin system_Homo sapiens_hsa046140.38231714
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.36884155
127Systemic lupus erythematosus_Homo sapiens_hsa053220.34992807
128ABC transporters_Homo sapiens_hsa020100.34678346
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32548341
130Epstein-Barr virus infection_Homo sapiens_hsa051690.28906061
131Alzheimers disease_Homo sapiens_hsa050100.28402824
132Steroid biosynthesis_Homo sapiens_hsa001000.27269050

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »